MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Congenital diaphragmatic hernia

(UMLS:C0235833)

Definition:: Protrusion of abdominal structures into the THORAX as a result of embryologic defects in the DIAPHRAGM often present in the neonatal period. It can be isolated, syndromic, nonsyndromic or be a part of chromosome abnormality. Associated pulmonary hypoplasia and PULMONARY HYPERTENSION can further complicate stabilization and surgical intervention.
UMLS ID:: C0235833
MeSH ID:: D065630

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.433

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.300.707.500.116

Synonym(s)

Congenital diaphragmatic hernia

CDH - Congenital diaphragmatic hernia

Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia, NOS

DIAPHRAGMATIC HERNIA, CONGENITAL

Diaphragmatic hernia

congenital diaphragmatic hernia

defect; diaphragm, congenital, with hernia

diaphragm; defect, congenital with hernia

10.

hernia; diaphragm defect, congenital

11.

hernia; diaphragmatic, congenital

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 14	US FAERS
2	Fluoxetine	FAERS: 13	US FAERS
3	Ondansetron	FAERS: 9	US FAERS
4	Lamotrigine	FAERS: 7	OFFSIDES US FAERS
5	Methotrexate	FAERS: 4	US FAERS
6	Carbamazepine	FAERS: 3	US FAERS
7	Lithium	FAERS: 3	US FAERS
8	Sertraline	FAERS: 3	US FAERS
9	Allopurinol	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
10	Aripiprazole	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
11	Bosentan	FAERS: 2	US FAERS
12	Dexamethasone	FAERS: 2	US FAERS
13	Fiorinal W/codeine	FAERS: 2	US FAERS
14	Hydroxyzine	FAERS: 2	US FAERS
15	Metformin	FAERS: 2	US FAERS
16	Mycophenolic Acid	FAERS: 2	US FAERS
17	Norgestrel	FAERS: 2	US FAERS
18	Orlistat	FAERS: 2	US FAERS
19	Sulfasalazine	FAERS: 2	US FAERS
20	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
21	Atorvastatin	FAERS: 1	US FAERS
22	Bupropion	FAERS: 1	US FAERS
23	Cetirizine	FAERS: 1	US FAERS
24	Citalopram	FAERS: 1	US FAERS
25	Citalopram	FAERS: 1	US FAERS
26	Dimenhydrinate	FAERS: 1	US FAERS
27	Duloxetine Hydrochloride	FAERS: 1	US FAERS
28	Gefitinib	FAERS: 1	US FAERS
29	Imatinib Mesylate	FAERS: 1	US FAERS
30	Imipramine	FAERS: 1	US FAERS
31	Lopinavir/Ritonavir	FAERS: 1	US FAERS
32	Methylergonovine	FAERS: 1	US FAERS
33	Methylphenidate	FAERS: 1	US FAERS
34	Oxcarbazepine	FAERS: 1	US FAERS
35	Quetiapine Fumarate	FAERS: 1	US FAERS
36	Sertraline	FAERS: 1	US FAERS
37	Tacrolimus	FAERS: 1	US FAERS
38	Topiramate	FAERS: 1	US FAERS
39	Tretinoin	FAERS: 1	US FAERS
40	Valproic Acid	FAERS: 1	US FAERS
41	Valproic Acid	FAERS: 1	US FAERS
42	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
43	perampanel	FAERS: 1	US FAERS
44	treprostinil	FAERS: 1	US FAERS
45	zolmitriptan	FAERS: 1	US FAERS
46	Clopenthixol		OFFSIDES
47	Codeine		OFFSIDES
48	Flumazenil		OFFSIDES
49	Leucovorin		OFFSIDES
50	Medroxyprogesterone		SIDER
51	Paroxetine	Canada Vigilance: 1	Canada Vigilance
52	Piroxicam	Canada Vigilance: 1	Canada Vigilance
53	Prazepam		OFFSIDES
54	Saquinavir		OFFSIDES
55	Tenofovir		OFFSIDES
56	Terbutaline		OFFSIDES
57	cefprozil		OFFSIDES
58	dihydroxyaluminum sodium carbonate		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Beckwith-Wiedemann Syndrome	28.2%
2	Wolf-Hirschhorn Syndrome	28.2%
3	Abnormalities, Drug-Induced	27.6%
4	Situs Inversus	27.6%
5	Holoprosencephaly	26.6%
6	Meningocele	24%
7	Encephalocele	24%
8	Smith-Magenis syndrome	23.7%
9	Cri-du-Chat Syndrome	23.3%
10	Down Syndrome	23.3%
11	Trisomy 21	23.3%
12	Anencephaly	22%
13	Eye Abnormalities	21.6%
14	Cardiovascular Abnormalities	21.6%
15	Gastroschisis	21.6%
16	Aicardi's syndrome	21.6%
17	Rubinstein-Taybi Syndrome	21%
18	Skin Abnormalities	20.9%
19	Lymphatic Abnormalities	20.9%
20	Congenital Microtia	20.9%
21	Prune Belly Syndrome	20.2%
22	Twins, Conjoined	20.2%
23	Waardenburg Syndrome	20.2%
24	Incisional hernia	20.2%
25	Ectodermal Dysplasia	20.1%
26	Aplasia Cutis Congenita	20.1%
27	Prader-Willi Syndrome	19.9%
28	Maxillofacial Abnormalities	18.5%
29	Dural Arteriovenous Fistula	18.5%
30	Dextrocardia	18.3%
31	CHARGE Syndrome	17.7%
32	Rectocele	17.5%
33	Kartagener Syndrome	17.5%
34	Urogenital Abnormalities	17.3%
35	Calculi	17.2%
36	Hypertrophy	17.2%
37	Nails, Malformed	17.2%
38	polyps	17.2%
39	Rupture, Spontaneous	17.2%
40	Atheroma	17.2%
41	Stenosis	17.2%
42	Facial asymmetry	17.2%
43	Plaque, Amyloid	17.2%
44	Plaque, Atherosclerotic	17.2%
45	Microcephaly	15.6%
46	Macrocephaly	15.6%
47	Umbilical hernia	15.6%
48	Marfan Syndrome	15.4%
49	Anophthalmos	15.4%
50	Anus, Imperforate	15.4%
51	Hydranencephaly	15.4%
52	Microphthalmos	15.4%
53	Neural Tube Defects	15.4%
54	Tethered Cord Syndrome	15.4%
55	Iniencephaly	15.4%
56	Craniorachischisis	15.4%
57	Limb Deformities, Congenital	15.4%
58	Exencephaly	15.4%
59	Septo-Optic Dysplasia	15.4%
60	Craniofacial Abnormalities	15.4%
61	Cortical Dysplasia	15.4%
62	Malformations of Cortical Development	15.4%
63	Anorectal Malformations	15.4%
64	Bloom Syndrome	15.1%
65	Nail-Patella Syndrome	14.9%
66	Xeroderma	14.7%
67	Mobius Syndrome	14.7%
68	Porencephaly	14.7%
69	Acrocephalosyndactylia	14.5%
70	Classical Lissencephalies and Subcortical Band Heterotopias	14.5%
71	Genetic Diseases, Inborn	14.5%
72	Craniosynostosis	14.1%
73	Syndactyly	14.1%
74	Brachycephaly	14.1%
75	Scimitar Syndrome	14.1%
76	Fragile X Syndrome	14%
77	Vascular Remodeling	14%
78	Alstrom Syndrome	13.7%
79	Cyst	13.5%
80	Polycystic Kidney Diseases	13.2%
81	Williams Syndrome	13.2%
82	Leukoplakia	13%
83	Airway Remodeling	13%
84	Turner Syndrome	13%
85	Ventricular Remodeling	12.8%
86	Alopecia	12.7%
87	Androgenetic Alopecia	12.7%
88	Noonan Syndrome	12.6%
89	Poland Syndrome	12.5%
90	Amelia	12.5%
91	Arachnodactyly	12.5%
92	Cockayne Syndrome	12.5%
93	Ectopia Cordis	12.5%
94	Ectromelia	12.5%
95	Hemimelia	12.5%
96	Meningomyelocele	12.5%
97	Phocomelia	12.5%
98	Sirenomelia	12.5%
99	Spina Bifida	12.5%
100	Polydactyly	12.5%
101	Brachydactyly	12.5%
102	Plagiocephaly	12.5%
103	Lower Extremity Deformities, Congenital	12.5%
104	Upper Extremity Deformities, Congenital	12.5%
105	Single umbilical artery	12.5%
106	Primary Ciliary Dyskinesia	12.5%
107	Blepharophimosis	12.4%
108	Laryngostenosis	12.4%
109	Mouth Abnormalities	12.4%
110	Cleft Palate	12.3%
111	Esophageal Atresia	12.2%
112	Intestinal Atresia	12.2%
113	Horseshoe Kidney	12.2%
114	Pectus excavatum	12.2%
115	Klippel-Feil Syndrome	12.2%
116	Synostosis	12.2%
117	Acrodermatitis	12.1%
118	Lymphangiectasis, Intestinal	12.1%
119	Gianotti-Crosti Syndrome	12.1%
120	Jaw Abnormalities	11.9%
121	Retinal Dysplasia	11.8%
122	Aniridia	11.7%
123	Epidermolysis Bullosa	11.5%
124	Smith-Lemli-Opitz Syndrome	11.5%
125	Abnormalities, Radiation-Induced	11.5%
126	Ichthyosis, X-Linked	11.4%
127	Klinefelter Syndrome	11.4%
128	Dermal Sinus	11.1%
129	Spina Bifida Cystica	11.1%
130	Spina Bifida Occulta	11.1%
131	Lissencephaly	11.1%
132	Polymicrogyria	11.1%
133	Pachygyria	11.1%
134	Schizencephaly	11.1%
135	Periventricular Nodular Heterotopia	11.1%
136	Polycystic Kidney, Autosomal Dominant	10.9%
137	Signs and Symptoms	10.8%
138	Fetal Diseases	10.8%
139	Micrognathism	10.7%
140	Pierre Robin Syndrome	10.7%
141	Arthrogryposis	10.4%
142	Choanal Atresia	10.4%
143	Tracheobronchomegaly	10.4%
144	Laryngocele	10.4%
145	Choledochal Cyst	10.3%
146	Hermaphroditism	10.3%
147	Disorders of Sex Development	10.3%
148	Cryptorchidism	10.2%
149	Hypospadias	10.2%
150	Intestinal Polyps	10.1%
151	Splenomegaly	10.1%
152	Central Nervous System Cysts	10.1%
153	Diverticulum	10.1%
154	Diverticulosis	10.1%
155	Dandy-Walker Syndrome	10.1%
156	Aortic coarctation	10%
157	Cor Triatriatum	10%
158	Coronary Vessel Anomalies	10%
159	Dental Enamel Hypoplasia	10%
160	Patent ductus arteriosus	10%
161	Ebstein Anomaly	10%
162	Heart Septal Defects	10%
163	Hypodontia	10%
164	Long QT Syndrome	10%
165	Macrostomia	10%
166	Microstomia	10%
167	Tetralogy of Fallot	10%
168	Transposition of Great Vessels	10%
169	Hypoplastic Left Heart Syndrome	10%
170	May-Thurner Syndrome	10%
171	POEMS Syndrome	9.9%
172	Craniofacial Dysostosis	9.9%
173	Wolff-Parkinson-White Syndrome	9.9%
174	Retrognathia	9.6%
175	Hyperkeratosis, Epidermolytic	9.5%
176	Sjogren-Larsson Syndrome	9.4%
177	Charcot-Marie-Tooth Disease	9.4%
178	Antley-Bixler Syndrome Phenotype	9.4%
179	Cystic Fibrosis	9.4%
180	Abdominal Cramps	9.2%
181	Amniotic Band Syndrome	9.2%
182	Asphyxia Neonatorum	9.2%
183	Infant, Premature, Diseases	9.2%
184	Infantile Colic	9.2%
185	Pseudoxanthoma Elasticum	9%
186	Kallmann Syndrome	8.9%
187	Laryngomalacia	8.9%
188	Aortopulmonary Septal Defect	8.9%
189	Double Outlet Right Ventricle	8.9%
190	Endocardial Cushion Defects	8.9%
191	Myocardial bridging	8.9%
192	Aorticopulmonary Septal Defect	8.9%
193	Pectus carinatum	8.8%
194	Hyperandrogenism	8.7%
195	Polydipsia	8.7%
196	Bladder Exstrophy	8.7%
197	Epispadias	8.7%
198	Prognathism	8.6%
199	Multicystic Dysplastic Kidney	8.6%
200	Romano-Ward Syndrome	8.4%
201	Platybasia	8.3%
202	Tricuspid Atresia	8.3%
203	Arrhythmogenic Right Ventricular Dysplasia	8.3%
204	Truncus Arteriosus, Persistent	8.3%
205	Gonadal Dysgenesis	8.3%
206	Bronchomalacia	8.3%
207	Adrenogenital Syndrome	8.3%
208	Tracheomalacia	8.3%
209	Ovotesticular Disorders of Sex Development	8.3%
210	Goldenhar Syndrome	8.3%
211	Xeroderma Pigmentosum	8.1%
212	Arteriovenous fistula	8%
213	Respiratory Tract Fistula	8%
214	Tuberous Sclerosis	7.9%
215	Meconium Aspiration Syndrome	7.9%
216	Cardiomegaly	7.7%
217	Hepatomegaly	7.7%
218	Parovarian Cyst	7.7%
219	Spermatocele	7.7%
220	Oral Fistula	7.7%
221	Cutaneous Fistula	7.7%
222	Cardiac Hypertrophy	7.7%
223	Zellweger Syndrome	7.7%
224	Refsum Disease	7.5%
225	Vaginal Fistula	7.5%
226	Fetal Growth Retardation	7.5%
227	Mandibulofacial Dysostosis	7.4%
228	Muscular Atrophy	7.3%
229	Neoplastic Syndromes, Hereditary	7.2%
230	Basal Cell Nevus Syndrome	7.2%
231	Talipes	7%
232	Anemia, Neonatal	6.8%
233	Multiple Epiphyseal Dysplasia	6.8%
234	Osteochondrodysplasias	6.8%
235	Pelger-Huet Anomaly	6.8%
236	Persistent Fetal Circulation Syndrome	6.8%
237	Werner Syndrome	6.8%
238	Myasthenic Syndromes, Congenital	6.8%
239	Fetal Hypoxia	6.8%
240	Familial Mediterranean Fever	6.7%
241	Congenital clubfoot	6.7%
242	Vertical Talus	6.7%
243	Colonic Polyps	6.7%
244	Anemia, Sickle Cell	6.6%
245	Thalassemia	6.6%
246	Muscular Dystrophy, Duchenne	6.6%
247	Rett Syndrome	6.6%
248	Albinism	6.3%
249	Nasal Polyps	6.2%
250	Mucopolysaccharidosis II	6.1%
251	Urinary Calculi	6%
252	Ascites	5.7%
253	Asthenia	5.7%
254	Body Temperature Changes	5.7%
255	Cyanosis	5.7%
256	Edema	5.7%
257	Failure to Thrive	5.7%
258	Fatigue	5.7%
259	Feminization	5.7%
260	Fetal Distress	5.7%
261	Fibrosis	5.7%
262	Gliosis	5.7%
263	Growth Disorders	5.7%
264	Hemorrhage	5.7%
265	Hyperbilirubinemia	5.7%
266	Hyperplasia	5.7%
267	Hypomenorrhea	5.7%
268	Inflammation	5.7%
269	Intraoperative Complications	5.7%
270	Ischemia	5.7%
271	Lithiasis	5.7%
272	Malacoplakia	5.7%
273	Menstruation Disturbances	5.7%
274	Metaplasia	5.7%
275	Motion Sickness	5.7%
276	Nerve Degeneration	5.7%
277	Ochronosis	5.7%
278	Polymenorrhea	5.7%
279	Postoperative Complications	5.7%
280	Sclerosis	5.7%
281	Shock	5.7%
282	Signs and Symptoms, Digestive	5.7%
283	Signs and Symptoms, Respiratory	5.7%
284	Skin Manifestations	5.7%
285	Ulcer	5.7%
286	Chills	5.7%
287	Lassitude	5.7%
288	Hyperammonemia	5.7%
289	Hyperamylasemia	5.7%
290	Teratogenesis	5.7%
291	Cardiac Death	5.7%
292	Hypovolemia	5.7%
293	Pseudophakia	5.7%
294	Hyperuricemia	5.7%
295	Urological Manifestations	5.7%
296	Leukoaraiosis	5.7%
297	Dysbacteriosis	5.7%
298	Mobility Limitation	5.7%
299	Delayed Graft Function	5.7%
300	Cirrhosis	5.7%
301	Somnolence	5.7%
302	Neointima	5.7%
303	Dysbiosis	5.7%
304	Dwarfism	5.7%
305	Neonatal Abstinence Syndrome	5.6%
306	Sickle Cell Trait	5.4%
307	Menkes Kinky Hair Syndrome	5.4%
308	Muscular Dystrophy	5.4%
309	Osteogenesis Imperfecta	5.4%
310	Congenital nystagmus	5.4%
311	Fetal Alcohol Spectrum Disorders	5.4%
312	Toxoplasmosis, Congenital	5.4%
313	Syphilis, Congenital	5.3%
314	Paralysis, Obstetric	5.1%
315	Retinopathy of Prematurity	5.1%
316	Biliary Fistula	5.1%
317	Gastric Fistula	5.1%
318	Amino Acid Metabolism, Inborn Errors	5%
319	Carbohydrate Metabolism, Inborn Errors	5%
320	Infarction	5%
321	Metal Metabolism, Inborn Errors	5%
322	Postoperative Hemorrhage	5%
323	Progeria	5%
324	Shock, Hemorrhagic	5%
325	Lysosomal Storage Diseases	5%
326	Systemic Inflammatory Response Syndrome	5%
327	Cytochrome-c Oxidase Deficiency	5%
328	Peroxisomal Disorders	5%
329	jaundice	5%
330	Bronchopulmonary Dysplasia	5%
331	Dental Fistula	5%
332	Leukoplakia, Oral	5%
333	Oroantral Fistula	5%
334	Left Ventricular Hypertrophy	5%
335	Right Ventricular Hypertrophy	5%
336	Hydrops Fetalis	5%
337	Wiskott-Aldrich Syndrome	5%
338	Rectal Prolapse	5%
339	Uterine Prolapse	5%
340	Vaginal Prolapse	5%
341	Neuronal Ceroid-Lipofuscinoses	4.9%
342	Sarcopenia	4.9%
343	Vesicovaginal Fistula	4.9%
344	Postoperative Nausea and Vomiting	4.6%
345	Autoimmune Lymphoproliferative Syndrome	4.6%
346	Congenital Hyperinsulinism	4.5%
347	Extravasation of Diagnostic and Therapeutic Materials	4.5%
348	Eye Manifestations	4.5%
349	Neoplastic Processes	4.5%
350	Neurologic Manifestations	4.5%
351	Chorioamnionitis	4.5%
352	Angioedemas, Hereditary	4.4%
353	Myotonic Dystrophy	4.4%
354	Adrenoleukodystrophy	4.4%
355	Necrosis	4.3%
356	Cardiac Output, High	4.3%
357	Myocardial Stunning	4.3%
358	Reticulocytosis	4.3%
359	Granulomatosis, Orofacial	4.3%
360	Pigmentation Disorders	4.3%
361	Low Cardiac Output Syndrome	4.3%
362	Respiratory Aspiration	4.3%
363	Glycogen storage disease type II	4.3%
364	Fabry Disease	4.3%
365	Acantholysis	4.3%
366	Chromosome Aberrations	4.3%
367	Dehydration	4.3%
368	Granuloma	4.3%
369	Leukocytosis	4.3%
370	Pleocytosis	4.3%
371	Denys-Drash Syndrome	4.3%
372	Intermittent Claudication	4.2%
373	Eye Hemorrhage	4.2%
374	Acute Chest Syndrome	4.2%
375	Abdominal Pain	4.2%
376	Mucopolysaccharidosis III	4.2%
377	Pain, Postoperative	4.2%
378	Respiratory Distress Syndrome, Newborn	4.1%
379	Alkaptonuria	4.1%
380	Glycogen Storage Disease	4.1%
381	Hypophosphatasia	4.1%
382	Propionic acidemia	4.1%
383	Dihydropyrimidine Dehydrogenase Deficiency	4.1%
384	Cystinosis	4.1%
385	Bronchial Fistula	4.1%
386	Pancreatic Fistula	4.1%
387	Cutis Laxa	4.1%
388	Hemoptysis	4.1%
389	Galactosemias	4.1%
390	Urea Cycle Disorders, Inborn	4.1%
391	Tyrosinemias	4.1%
392	Hepatolenticular Degeneration	4.1%
393	Intestinal Fistula	4.1%
394	Retinitis Pigmentosa	4.1%
395	Enterocutaneous Fistula	4.1%
396	Pigmentary retinopathy	4.1%
397	Ecchymosis	4%
398	Petechiae	4%
399	Purpura	4%
400	Porokeratosis	4%
401	Keratoderma, Palmoplantar	4%
402	Chronic granulomatous disease	4%
403	Salivary Gland Fistula	4%
404	Amyloid Neuropathies, Familial	4%
405	Muscle Weakness	4%
406	Cystocele	4%
407	Welander Distal Myopathy	4%
408	Renal Colic	3.9%
409	Kernicterus	3.8%
410	Dysmenorrhea	3.7%
411	Failed Back Surgery Syndrome	3.7%
412	Gaucher Disease	3.7%
413	Glycogen Storage Disease Type I	3.7%
414	Glycogen Storage Disease Type V	3.7%
415	Optic Atrophy, Hereditary, Leber	3.6%
416	Hyperphosphaturia	3.6%
417	Genomic Instability	3.5%
418	Tay-Sachs Disease	3.5%
419	Homocystinuria	3.5%
420	Hypergammaglobulinemia	3.4%
421	Leigh Disease	3.4%
422	Duane Retraction Syndrome	3.4%
423	Epistaxis	3.4%
424	Canavan Disease	3.4%
425	Alexander Disease	3.4%
426	Porphyrias, Hepatic	3.4%
427	Eye pain	3.4%
428	Acute Disease	3.4%
429	Acute-Phase Reaction	3.4%
430	Amenorrhea	3.4%
431	Anorexia	3.4%
432	Anoxia	3.4%
433	Chronic disease	3.4%
434	Constipation	3.4%
435	Critical Illness	3.4%
436	Sudden death	3.4%
437	Diarrhea	3.4%
438	Dyspepsia	3.4%
439	Eructation	3.4%
440	Fat necrosis	3.4%
441	Fever	3.4%
442	Flatulence	3.4%
443	Flushing	3.4%
444	Gangrene	3.4%
445	Graft Occlusion, Vascular	3.4%
446	Granuloma, Plasma Cell	3.4%
447	Halitosis	3.4%
448	Heartburn	3.4%
449	Hematoma	3.4%
450	Hiccough	3.4%
451	Hypercalciuria	3.4%
452	Hypercapnia	3.4%
453	Hyperphagia	3.4%
454	Iatrogenic Disease	3.4%
455	Multiple Organ Failure	3.4%
456	Nausea	3.4%
457	Oligomenorrhea	3.4%
458	Pallor	3.4%
459	Premenstrual syndrome	3.4%
460	Psychophysiologic Disorders	3.4%
461	Recurrence	3.4%
462	Retrograde Degeneration	3.4%
463	Retroperitoneal fibrosis	3.4%
464	Serositis	3.4%
465	Subcutaneous Emphysema	3.4%
466	Surgical Wound Dehiscence	3.4%
467	Syndrome	3.4%
468	Vomiting	3.4%
469	Wallerian Degeneration	3.4%
470	Hypocapnia	3.4%
471	Pyogenic granuloma	3.4%
472	Exsanguination	3.4%
473	Dyschezia	3.4%
474	Hypoxia	3.4%
475	Disease Progression	3.4%
476	Hyperoxia	3.4%
477	Seroma	3.4%
478	Premenstrual Tension	3.4%
479	Delayed Emergence from Anesthesia	3.4%
480	Infant Death	3.4%
481	Lower Urinary Tract Symptoms	3.4%
482	Hypoxemia	3.4%
483	Anastomotic Leak	3.4%
484	Intraoperative Awareness	3.4%
485	Chromosomal Instability	3.4%
486	Urinoma	3.4%
487	Azotemia	3.3%
488	Peutz-Jeghers Syndrome	3.3%
489	Hyaline Membrane Disease	3.3%
490	Myotonia Congenita	3.3%
491	Thrombasthenia	3.3%
492	Antithrombin III Deficiency	3.3%
493	Protein C Deficiency	3.3%
494	Brain Diseases, Metabolic, Inborn	3.3%
495	Afibrinogenemia	3.3%
496	Dystonia Musculorum Deformans	3.3%
497	Factor VII Deficiency	3.3%
498	Factor X Deficiency	3.3%
499	Factor XII Deficiency	3.3%
500	Hemophilia A	3.3%
501	Leukomalacia, Periventricular	3.3%
502	Activated Protein C Resistance	3.3%
503	Factor II deficiency	3.3%
504	Factor VIII Deficiency	3.3%
505	Factor V deficiency	3.3%
506	Factor XI Deficiency	3.3%
507	Hypoprothrombinemias	3.3%
508	Jaundice, Obstructive	3.3%
509	Sudden infant death syndrome	3.3%
510	Menorrhagia	3.3%
511	Fanconi Anemia	3.3%
512	Nesidioblastosis	3.3%
513	Ophthalmia Neonatorum	3.3%
514	Hypolipoproteinemias	3.3%
515	Papillon-Lefevre Disease	3.3%
516	Lafora Disease	3.3%
517	Unverricht-Lundborg Syndrome	3.3%
518	Niemann-Pick Disease, Type C	3.3%
519	Hyperlipidemia, Familial Combined	3.3%
520	Anemia, Diamond-Blackfan	3.3%
521	Hyperlipoproteinemia Type III	3.3%
522	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.2%
523	Ataxia Telangiectasia	3%
524	Multiple Endocrine Neoplasia	3%
525	Hypoalphalipoproteinemias	2.9%
526	Congenital Hypothyroidism	2.9%
527	Abdomen, Acute	2.9%
528	Cardiotoxicity	2.9%
529	Dermatitis, Atopic	2.9%
530	Urinary Bladder Fistula	2.8%
531	Familial Periodic Paralysis	2.8%
532	Lactose Intolerance	2.7%
533	Variegate Porphyria	2.7%
534	Acute intermittent porphyria	2.7%
535	Porphyria Cutanea Tarda	2.7%
536	Hyperhomocysteinemia	2.7%
537	Renal Aminoacidurias	2.7%
538	Fanconi Syndrome	2.7%
539	Pseudohypoaldosteronism	2.7%
540	Liddle Syndrome	2.7%
541	Hyperlipoproteinemia Type IV	2.7%
542	Hyperlipoproteinemia Type V	2.7%
543	Asphyxia	2.7%
544	Granuloma, Respiratory Tract	2.7%
545	Shock, Traumatic	2.7%
546	Hematemesis	2.6%
547	Purpura Fulminans	2.6%
548	Apnea	2.6%
549	Cheyne-Stokes Respiration	2.6%
550	Decerebrate State	2.6%
551	Disease susceptibility	2.6%
552	Dyspnea	2.6%
553	Fetal Death	2.6%
554	Foreign-Body Reaction	2.6%
555	Gastrointestinal Hemorrhage	2.6%
556	Hemarthrosis	2.6%
557	Hemiparesis	2.6%
558	Hemoperitoneum	2.6%
559	Hemothorax	2.6%
560	Hyperventilation	2.6%
561	Meningism	2.6%
562	Mouth Breathing	2.6%
563	Neoplasm Invasiveness	2.6%
564	Neoplasm Metastasis	2.6%
565	Neoplasm Recurrence, Local	2.6%
566	Paresis	2.6%
567	Postpericardiotomy Syndrome	2.6%
568	Prosthesis Failure	2.6%
569	Pruritus	2.6%
570	Reperfusion Injury	2.6%
571	Seizures	2.6%
572	Sensation Disorders	2.6%
573	Sneezing	2.6%
574	Erythema	2.6%
575	Complex partial seizures	2.6%
576	Injection Site Reaction	2.6%
577	Necrolytic Migratory Erythema	2.6%
578	Tachypnea	2.6%
579	Monoparesis	2.6%
580	Retrobulbar Hemorrhage	2.6%
581	Aseptic Necrosis of Bone	2.6%
582	Peritoneal Fibrosis	2.6%
583	Carcinogenesis	2.6%
584	Neurogenic Inflammation	2.6%
585	Perinatal death	2.6%
586	Gait Disorders, Neurologic	2.6%
587	Neuromuscular Manifestations	2.6%
588	Infusion site reaction	2.6%
589	Nephrogenic Fibrosing Dermopathy	2.6%
590	Corneal Endothelial Cell Loss	2.6%
591	Encapsulating Peritoneal Sclerosis	2.6%
592	Vasoplegia	2.6%
593	Suppuration	2.6%
594	Nephrogenic Systemic Fibrosis	2.6%
595	Metastasis	2.6%
596	Sinus Arrhythmia	2.5%
597	Atrial Fibrillation	2.5%
598	Atrial Flutter	2.5%
599	Dental Pulp Necrosis	2.5%
600	Edema, Cardiac	2.5%
601	Mental Fatigue	2.5%
602	Granuloma, Foreign-Body	2.5%
603	Hirsutism	2.5%
604	Mediastinal Emphysema	2.5%
605	Surgical Wound Infection	2.5%
606	Ventricular Fibrillation	2.5%
607	Ventricular Flutter	2.5%
608	Parasystole	2.5%
609	Paroxysmal atrial fibrillation	2.5%
610	Facies	2.5%
611	Bradycardia	2.5%
612	Embryo Loss	2.5%
613	Orthostatic intolerance	2.5%
614	Hypoventilation	2.5%
615	Behcet Syndrome	2.5%
616	Afferent Loop Syndrome	2.5%
617	Sex Chromosome Aberrations	2.5%
618	Short Bowel Syndrome	2.5%
619	Uterine hemorrhage	2.5%
620	No-Reflow Phenomenon	2.5%
621	Body Weight Changes	2.5%
622	Rectal Fistula	2.5%
623	Anal Fistula	2.5%
624	Hypokalemic periodic paralysis	2.5%
625	Cystinuria	2.4%
626	Gout	2.4%
627	Multiple Endocrine Neoplasia Type 1	2.4%
628	Pseudohypoparathyroidism	2.4%
629	Body Weight	2.4%
630	Friedreich Ataxia	2.3%
631	Phantom pain	2.3%
632	Phantom Limb Pain	2.3%
633	Renal tubular acidosis	2.3%
634	Endotoxic shock	2.3%
635	Septic Shock	2.3%
636	Toxic Shock Syndrome	2.3%
637	Tissue Adhesions	2.2%
638	Back Pain	2.2%
639	Bulimia	2.2%
640	Neck Pain	2.2%
641	Chest Pain	2.2%
642	Dizziness	2.2%
643	Dysuria	2.2%
644	Facial Pain	2.2%
645	Fever of Unknown Origin	2.2%
646	Flank Pain	2.2%
647	Headache	2.2%
648	Nocturia	2.2%
649	Pain, Intractable	2.2%
650	Pelvic Pain	2.2%
651	Snoring	2.2%
652	Chronic pain	2.2%
653	Lightheadedness	2.2%
654	Pain, Referred	2.2%
655	Prostatism	2.2%
656	Throbbing Headache	2.2%
657	Labor Pain	2.2%
658	Cancer Pain	2.2%
659	Hematoma, Epidural, Spinal	2.2%
660	Nociceptive Pain	2.2%
661	Huntington Disease	2.2%
662	Chromosome Fragility	2.2%
663	Sleep Wake Disorders	2.2%
664	Kidney Calculi	2.2%
665	Ureteral Calculi	2.2%
666	Pupil Disorders	2.1%
667	Neurobehavioral Manifestations	2.1%
668	Arthritis, Gouty	2.1%
669	Hoarseness	2.1%
670	Drowning	2.1%
671	Familial Hypophosphatemic Rickets	2.1%
672	Pleural Rub	2%
673	Rales	2%
674	Respiratory Sounds	2%
675	Rhonchi	2%
676	Stridor	2%
677	Wheezing	2%
678	Asterixis	2%
679	Ballismus	2%
680	DNA Degradation, Necrotic	2%
681	Aneuploidy	2%
682	Polyploidy	2%
683	Vertigo	2%
684	Microsatellite Instability	2%
685	Heart Block	2%
686	Pain	2%
687	Tachycardia	2%
688	Tachyarrhythmia	2%
689	Livedo Reticularis	2%
690	Ache	2%
691	Cicatrix	2%
692	Hematuria	2%
693	Oliguria	2%
694	Polyuria	2%
695	Proteinuria	2%
696	Granuloma Annulare	2%
697	Chromosome Breakage	2%
698	Brain Death	2%
699	Shock, Cardiogenic	2%
700	Nephroblastoma	2%
701	Underweight	2%
702	Overweight	2%
703	Thrombocytopenic purpura	1.9%
704	Gait Ataxia	1.9%
705	Purpura, Hyperglobulinemic	1.9%
706	Sick Sinus Syndrome	1.9%
707	Trisomy	1.9%
708	Glycosuria, Renal	1.8%
709	Adenomatous Polyposis Coli	1.8%
710	Voice Disorders	1.7%
711	Voice Disturbance	1.7%
712	Giant Cell Epulis	1.7%
713	Cross Infection	1.7%
714	Gagging	1.7%
715	Hyphema	1.7%
716	Retinal Neovascularization	1.7%
717	Septicemia	1.7%
718	Vitreous Hemorrhage	1.7%
719	Sepsis	1.7%
720	Morning Sickness	1.7%
721	Abscess	1.7%
722	Anosmia	1.7%
723	Ataxia	1.7%
724	Athetosis	1.7%
725	Catalepsy	1.7%
726	Dystonia	1.7%
727	Empyema	1.7%
728	Femur Head Necrosis	1.7%
729	Fetal Resorption	1.7%
730	Hemiplegia	1.7%
731	Locked-In Syndrome	1.7%
732	Lymphatic Metastasis	1.7%
733	Muscle Hypertonia	1.7%
734	Muscle hypotonia	1.7%
735	Myoclonus	1.7%
736	Myotonia	1.7%
737	Neoplasms, Unknown Primary	1.7%
738	Neuralgia	1.7%
739	Paraplegia	1.7%
740	Peptic Ulcer Hemorrhage	1.7%
741	Pseudobulbar Palsy	1.7%
742	Quadriplegia	1.7%
743	Spasm	1.7%
744	Spastic Paraplegia	1.7%
745	Status Epilepticus	1.7%
746	Taste Disorders	1.7%
747	Tremor	1.7%
748	Sudden Cardiac Death	1.7%
749	Monoplegia	1.7%
750	Hypokinesia	1.7%
751	Gastroparesis	1.7%
752	Leukemic Infiltration	1.7%
753	Paraparesis	1.7%
754	Bradykinesia	1.7%
755	Waxy flexibility	1.7%
756	Action Tremor	1.7%
757	Resting Tremor	1.7%
758	Dysosmia	1.7%
759	Quadriparesis	1.7%
760	Premenstrual Dysphoric Disorder	1.7%
761	Olfaction Disorders	1.7%
762	Choroidal Neovascularization	1.7%
763	Myokymia	1.7%
764	Somatosensory Disorders	1.7%
765	Primary Graft Dysfunction	1.7%
766	Neoplasm Micrometastasis	1.7%
767	Neuropathic pain	1.7%
768	Hyperkinesia	1.7%
769	Intention tremor	1.7%
770	Emaciation	1.7%
771	Low Back Pain	1.7%
772	Visceral Pain	1.7%
773	Hematoma, Subdural, Spinal	1.7%
774	Dumping Syndrome	1.7%
775	Cicatrix, Hypertrophic	1.7%
776	Sinus Arrest, Cardiac	1.7%
777	Akathisia	1.6%
778	Restlessness	1.6%
779	Psychomotor Agitation	1.6%
780	Metrorrhagia	1.6%
781	Weight Gain	1.6%
782	Micronuclei, Chromosome-Defective	1.6%
783	Hematoma, Subdural	1.6%
784	Hematoma, Epidural, Cranial	1.6%
785	Gait Apraxia	1.5%
786	MELAS Syndrome	1.5%
787	Subacute Combined Degeneration	1.5%
788	Jet Lag Syndrome	1.4%
789	Eosinophilic Granuloma	1.4%
790	Reflex, Abnormal	1.4%
791	Hyporeflexia	1.4%
792	Hyperreflexia	1.4%
793	Purpura, Thrombotic Thrombocytopenic	1.4%
794	Birth Weight	1.4%
795	Vision Disorders	1.4%
796	Metamorphopsia	1.4%
797	Visual Impairment	1.4%
798	Cachexia	1.4%
799	Metatarsalgia	1.4%
800	Retinal Hemorrhage	1.4%
801	Anisocoria	1.4%
802	Choroid Hemorrhage	1.4%
803	Confusion	1.4%
804	Facial paralysis	1.4%
805	Lethargy	1.4%
806	Melena	1.4%
807	Memory Disorders	1.4%
808	Muscle Cramp	1.4%
809	Perceptual Disorders	1.4%
810	Psychomotor Disorders	1.4%
811	Tonic Pupil	1.4%
812	Anhedonia	1.4%
813	Disorientation	1.4%
814	Facial Paresis	1.4%
815	Memory Loss	1.4%
816	Hemisensory Neglect	1.4%
817	Dysacusis	1.4%
818	Dyspnea, Paroxysmal	1.3%
819	Mastodynia	1.3%
820	Postpartum Hemorrhage	1.3%
821	Respiratory Paralysis	1.3%
822	Chorea	1.3%
823	Gingival Hemorrhage	1.3%
824	Keloid	1.3%
825	Tetany	1.3%
826	Urinary Incontinence	1.3%
827	Breakthrough Pain	1.3%
828	Monosomy	1.3%
829	Tetraploidy	1.3%
830	Stillbirth	1.3%
831	Adams-Stokes Syndrome	1.3%
832	Atrioventricular Block	1.3%
833	Bundle-Branch Block	1.3%
834	Atrial Premature Complexes	1.3%
835	Sinoatrial Block	1.3%
836	Tachycardia, Paroxysmal	1.3%
837	Supraventricular tachycardia	1.3%
838	Tachycardia, Ventricular	1.3%
839	Tachycardia, Reciprocating	1.3%
840	Albuminuria	1.3%
841	Hemoglobinuria	1.3%
842	Subarachnoid Hemorrhage	1.3%
843	Cerebral Hemorrhage	1.3%
844	Viremia	1.3%
845	Parasitemia	1.3%
846	Toothache	1.3%
847	Hyperemesis Gravidarum	1.2%
848	Dysgeusia	1.2%
849	Formication	1.2%
850	Hyperalgesia	1.2%
851	Hyperesthesia	1.2%
852	Hypesthesia	1.2%
853	Language Disorders	1.2%
854	Numbness	1.2%
855	Paresthesia	1.2%
856	Paraparesis, Spastic	1.2%
857	Trismus	1.2%
858	Epilepsia Partialis Continua	1.2%
859	Hypogeusia	1.2%
860	Brown-Sequard Syndrome	1.2%
861	Lockjaw	1.2%
862	Allodynia	1.2%
863	Ageusia	1.2%
864	Alice in Wonderland Syndrome	1.2%
865	Hematoma, Subdural, Intracranial	1.2%
866	Hematoma, Subdural, Chronic	1.2%
867	Hematoma, Subdural, Acute	1.2%
868	Waterhouse-Friderichsen Syndrome	1.2%
869	Alexia	1.2%
870	Dyslexia	1.2%
871	Consciousness Disorders	1.1%
872	Mental Retardation	1.1%
873	Depressed Level of Consciousness	1.1%
874	Mental deficiency	1.1%
875	Intellectual Disability	1.1%
876	Catatonia	1.1%
877	Cellulitis	1.1%
878	Musculoskeletal Pain	1.1%
879	Ophthalmoplegia	1.1%
880	External Ophthalmoplegia	1.1%
881	Aphonia	1.1%
882	Arthralgia	1.1%
883	Sleep Deprivation	1.1%
884	Polyarthralgia	1.1%
885	Dysphonia	1.1%
886	Autoimmune thrombocytopenia	1.1%
887	Immune thrombocytopenic purpura	1.1%
888	Cerebrospinal Fluid Otorrhea	1.1%
889	Cerebrospinal Fluid Rhinorrhea	1.1%
890	Fetal Weight	1.1%
891	Obesity	1.1%
892	Agraphia	1%
893	Anomia	1%
894	Cluttering	1%
895	Language Development Disorders	1%
896	Speech Disorders	1%
897	Syncope	1%
898	Stupor	1%
899	Dysgraphia	1%
900	Presyncope	1%
901	Dyslalia	1%
902	Bacteremia	1%
903	Cell Transformation, Viral	1%
904	Diplopia	1%
905	Muscle Rigidity	1%
906	Muscle Spasticity	1%
907	Scotoma	1%
908	Photophobia	1%
909	Cogwheel Rigidity	1%
910	Hemifacial Spasm	1%
911	Amaurosis	1%
912	Blindness	1%
913	Nuchal Rigidity	1%
914	Angina Pectoris	1%
915	Fungemia	1%
916	Agnosia	1%
917	Apraxias	1%
918	Hallucinations	1%
919	Hemianopsia	1%
920	Hyperacusis	1%
921	Tinnitus	1%
922	Visual Agnosia	1%
923	Anosognosia	1%
924	Wernicke-Korsakoff Syndrome	1%
925	Phonophobia	1%
926	Hearing Loss	1%
927	Cerebellar Ataxia	1%
928	Torticollis	1%
929	Granuloma, Laryngeal	1%
930	Sciatica	1%
931	Urge Incontinence	1%
932	Tardive Dyskinesia	1%
933	Tachycardia, Atrioventricular Nodal Reentry	1%
934	Tachycardia, Ectopic Atrial	1%
935	Tachycardia, Ectopic Junctional	1%
936	Sinus Tachycardia	1%
937	Torsades de Pointes	1%
938	Accelerated Idioventricular Rhythm	1%
939	Vocal Cord Paralysis	1%
940	Myocardial Reperfusion Injury	1%
941	Tinea Pedis	0.9%
942	Aphasia	0.9%
943	Articulation Disorders	0.9%
944	Echolalia	0.9%
945	Stuttering	0.9%
946	Dysphasia	0.9%
947	Dysarthria	0.9%
948	Dyskinesia, Drug-Induced	0.8%
949	Amblyopia	0.8%
950	Amnesia	0.8%
951	Delirium	0.8%
952	Horner Syndrome	0.8%
953	Dissociative Amnesia	0.8%
954	Color blindness	0.8%
955	Global Amnesia	0.8%
956	Alcohol Withdrawal Seizures	0.8%
957	Endotoxemia	0.8%
958	Amaurosis Fugax	0.8%
959	Blindness, Cortical	0.8%
960	Dyscalculia	0.8%
961	Angina, Unstable	0.8%
962	Shoulder Pain	0.8%
963	Deafness	0.8%
964	Hearing Loss, Sudden	0.8%
965	Gerstmann Syndrome	0.8%
966	Hearing Loss, Bilateral	0.8%
967	Hearing Loss, High-Frequency	0.8%
968	Hearing Loss, Mixed Conductive-Sensorineural	0.8%
969	Prosopagnosia	0.8%
970	Apraxia, Ideomotor	0.8%
971	Persistent Vegetative State	0.8%
972	Charles Bonnet Syndrome	0.8%
973	Hearing Loss, Unilateral	0.8%
974	Complete Hearing Loss	0.8%
975	Alien Hand Syndrome	0.8%
976	Deaf Mutism	0.8%
977	Pediatric Obesity	0.8%
978	Philadelphia Chromosome	0.8%
979	Mutism	0.7%
980	Selective Mutism	0.7%
981	Angina Pectoris, Variant	0.7%
982	Akathisia, Drug-Induced	0.7%
983	Myalgia	0.7%
984	Alexia, Pure	0.7%
985	Retrograde amnesia	0.7%
986	Amnesia, Anterograde	0.7%
987	Auditory Perceptual Disorders	0.6%
988	Basal Ganglia Hemorrhage	0.6%
989	Amnesia, Transient Global	0.6%
990	Candidemia	0.6%
991	Ophthalmoplegic Migraine	0.6%
992	Progressive supranuclear palsy	0.5%
993	Putaminal Hemorrhage	0.5%
994	Kearns-Sayre syndrome	0.3%

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