MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Noonan Syndrome

(UMLS:C0028326)

Definition:: A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.
UMLS ID:: C0028326
MeSH ID:: D009634

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.207.690

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.240.400.787|C14.280.400.787

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.240.400.784|C16.131.621.207.690

Classification 4:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.690

Synonym(s)

Noonan Syndrome

NOONAN SYNDROME

Noonan

Noonan syndrome

Noonan's Syndrome

Noonan's syndrome

Noonan-Ehmke syndrome

PSEUDO-TURNER SYNDROME

Turner phenotype with normal karyotype

10.

Turner phenotype, karyotype normal

11.

Turner syndrome in female with X chromosome

12.

Turner's phenotype, karyotype normal

13.

Turner-like syndrome

14.

Ullrich-Noonan syndrome

15.

familial Turner syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 9	US FAERS
2	Aripiprazole	FAERS: 3	US FAERS
3	Sertraline	FAERS: 2	US FAERS
4	pimecrolimus	FAERS: 2	OFFSIDES US FAERS
5	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
6	Dimethyl Fumarate	FAERS: 1	US FAERS
7	Glatiramer Acetate	FAERS: 1	US FAERS
8	Hydrocortisone	FAERS: 1	US FAERS
9	Modafinil	FAERS: 1	US FAERS
10	Azithromycin		OFFSIDES
11	Chlorothiazide		OFFSIDES
12	Digoxin		OFFSIDES
13	Docusate sodium		OFFSIDES
14	Ibuprofen		OFFSIDES
15	Lofepramine		OFFSIDES
16	Terbutaline		OFFSIDES
17	Triazolam		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Marfan Syndrome	40.3%
2	Dextrocardia	39.2%
3	Tricuspid Atresia	38.5%
4	Arrhythmogenic Right Ventricular Dysplasia	38.5%
5	Aortic coarctation	36.9%
6	Cor Triatriatum	36.9%
7	Coronary Vessel Anomalies	36.9%
8	Patent ductus arteriosus	36.9%
9	Ebstein Anomaly	36.9%
10	Heart Septal Defects	36.9%
11	Tetralogy of Fallot	36.9%
12	Transposition of Great Vessels	36.9%
13	Hypoplastic Left Heart Syndrome	36.9%
14	Holoprosencephaly	30.1%
15	Craniosynostosis	29.5%
16	Brachycephaly	29.5%
17	Ectopia Cordis	28.2%
18	Rubinstein-Taybi Syndrome	27.7%
19	Maxillofacial Abnormalities	27.4%
20	Aortopulmonary Septal Defect	27.4%
21	Double Outlet Right Ventricle	27.4%
22	Endocardial Cushion Defects	27.4%
23	Myocardial bridging	27.4%
24	Aorticopulmonary Septal Defect	27.4%
25	Plagiocephaly	26.6%
26	Acrocephalosyndactylia	25.2%
27	Craniofacial Dysostosis	24.6%
28	Microcephaly	24.1%
29	Macrocephaly	24.1%
30	Platybasia	23.9%
31	Kartagener Syndrome	23.7%
32	Pectus carinatum	23.3%
33	Truncus Arteriosus, Persistent	22.7%
34	Long QT Syndrome	22.6%
35	Turner Syndrome	22.3%
36	Wolff-Parkinson-White Syndrome	22%
37	Arthrogryposis	20.4%
38	Limb Deformities, Congenital	20.2%
39	Syndactyly	19.9%
40	Pectus excavatum	19.4%
41	Klippel-Feil Syndrome	19%
42	Synostosis	19%
43	Porencephaly	18.7%
44	Scimitar Syndrome	18.6%
45	Jaw Abnormalities	18.4%
46	Dural Arteriovenous Fistula	18.1%
47	Gastroschisis	17.8%
48	Pseudoxanthoma Elasticum	17.5%
49	Romano-Ward Syndrome	16.7%
50	Laryngomalacia	16.7%
51	Mandibulofacial Dysostosis	16.6%
52	Ectodermal Dysplasia	16.4%
53	Aplasia Cutis Congenita	16.4%
54	May-Thurner Syndrome	16.2%
55	Skin Abnormalities	16.1%
56	Beckwith-Wiedemann Syndrome	15.6%
57	Wolf-Hirschhorn Syndrome	15.6%
58	Goldenhar Syndrome	15.4%
59	Myocardial Ischemia	15.3%
60	Aicardi's syndrome	15.1%
61	Arteriovenous fistula	15.1%
62	Single umbilical artery	14.9%
63	Poland Syndrome	14.9%
64	Cartilage Diseases	14.7%
65	Rheumatism	14.7%
66	Chondromalacia	14.7%
67	Panniculitis, Lupus Erythematosus	14.6%
68	Myocardial Reperfusion Injury	14.5%
69	Micrognathism	14.5%
70	Pierre Robin Syndrome	14.5%
71	Abnormalities, Drug-Induced	14.4%
72	Situs Inversus	14.4%
73	Cleft Palate	14.2%
74	Smith-Magenis syndrome	14.1%
75	Cri-du-Chat Syndrome	14%
76	Down Syndrome	14%
77	Trisomy 21	14%
78	Lupus Erythematosus, Cutaneous	13.6%
79	Panniculitis	13.6%
80	Systemic Scleroderma	13.6%
81	Morphea	13.6%
82	Nail-Patella Syndrome	13.5%
83	Cutis Laxa	13.4%
84	Xeroderma	13.4%
85	Retrognathia	13.4%
86	Prognathism	13.4%
87	Aortic Valve Stenosis	13.3%
88	Cardiomyopathy, Dilated	13.3%
89	Pulmonary Valve Stenosis	13.3%
90	Amelia	13.3%
91	Arachnodactyly	13.3%
92	Ectromelia	13.3%
93	Hemimelia	13.3%
94	Phocomelia	13.3%
95	Sirenomelia	13.3%
96	Polydactyly	13.3%
97	Brachydactyly	13.3%
98	Lower Extremity Deformities, Congenital	13.3%
99	Upper Extremity Deformities, Congenital	13.3%
100	Eye Abnormalities	12.9%
101	Bronchomalacia	12.9%
102	Tracheomalacia	12.9%
103	Epidermolysis Bullosa	12.7%
104	Lymphatic Abnormalities	12.7%
105	Congenital Microtia	12.7%
106	Prader-Willi Syndrome	12.7%
107	Congenital diaphragmatic hernia	12.6%
108	Heart Block	11.9%
109	Tachycardia	11.9%
110	Tachyarrhythmia	11.9%
111	Dermatomyositis	11.7%
112	Cardiac Tamponade	11.5%
113	Collagen Diseases	11.5%
114	Endocarditis	11.5%
115	Cardiac Arrest	11.5%
116	Heart failure	11.5%
117	Mixed Connective Tissue Disease	11.5%
118	Pericardial effusion	11.5%
119	Pericarditis	11.5%
120	Pneumopericardium	11.5%
121	Cor pulmonale	11.5%
122	Urogenital Abnormalities	11.5%
123	Ventricular Outflow Obstruction	11.5%
124	Mucinoses	11.5%
125	Ventricular Dysfunction	11.5%
126	Cardiomyopathies	11.5%
127	Pleuropericarditis	11.5%
128	Osteogenesis Imperfecta	11.5%
129	Antley-Bixler Syndrome Phenotype	11.5%
130	Xeroderma Pigmentosum	11.5%
131	Osteochondritis	11.3%
132	Polymyalgia Rheumatica	11.3%
133	Williams Syndrome	11.2%
134	Acrodermatitis	11.1%
135	Gianotti-Crosti Syndrome	11.1%
136	Anencephaly	11.1%
137	Ichthyosis, X-Linked	11%
138	Cardiovascular Abnormalities	10.8%
139	Hypertrophic Cardiomyopathy	10.8%
140	Hypertrophic obstructive cardiomyopathy	10.8%
141	Sick Sinus Syndrome	10.7%
142	CHARGE Syndrome	10.4%
143	Dupuytren Contracture	10.4%
144	Lupus Erythematosus, Systemic	10.2%
145	Cardiac Output, High	10.2%
146	Myocardial Stunning	10.2%
147	Overlap syndrome	10.2%
148	Low Cardiac Output Syndrome	10.2%
149	Cardiomegaly	10.1%
150	Postpericardiotomy Syndrome	10.1%
151	Tietze's Syndrome	10.1%
152	Cardiac Hypertrophy	10.1%
153	Rheumatic Heart Disease	10%
154	Coronary heart disease	10%
155	Lupus Erythematosus, Discoid	10%
156	Myocardial Infarction	10%
157	Scleroderma, Limited	10%
158	Acute Coronary Syndrome	10%
159	Supravalvular aortic stenosis	9.9%
160	Lown-Ganong-Levine Syndrome	9.9%
161	Vascular Diseases	9.8%
162	Coronary Aneurysm	9.6%
163	Rheumatoid Arthritis	9.5%
164	Bacterial Endocarditis	9.5%
165	Juvenile arthritis	9.5%
166	Sjogren-Larsson Syndrome	9.4%
167	Mobius Syndrome	9.4%
168	CREST Syndrome	9.3%
169	Talipes	9.2%
170	Cockayne Syndrome	9.1%
171	Abnormalities, Radiation-Induced	9.1%
172	Necrobiosis Lipoidica Diabeticorum	9%
173	Kounis Syndrome	9%
174	Angina Pectoris	8.8%
175	Genetic Diseases, Inborn	8.8%
176	Adams-Stokes Syndrome	8.8%
177	Atrioventricular Block	8.8%
178	Bundle-Branch Block	8.8%
179	Coronary Thrombosis	8.8%
180	Atrial Premature Complexes	8.8%
181	Sinoatrial Block	8.8%
182	Tachycardia, Paroxysmal	8.8%
183	Supraventricular tachycardia	8.8%
184	Tachycardia, Ventricular	8.8%
185	Tachycardia, Reciprocating	8.8%
186	Coronary Artery Disease	8.8%
187	Erythema Induratum	8.7%
188	Pregnancy Complications, Cardiovascular	8.6%
189	Prune Belly Syndrome	8.6%
190	Twins, Conjoined	8.6%
191	Scleromyxedema	8.6%
192	Waardenburg Syndrome	8.6%
193	Hyperkeratosis, Epidermolytic	8.4%
194	Rheumatoid Vasculitis	8.4%
195	Alstrom Syndrome	8.3%
196	Malignant Atrophic Papulosis	8.1%
197	Rheumatoid Nodule	8.1%
198	Cellulitis	8%
199	Polycystic Kidney Diseases	7.9%
200	Carcinoid Heart Disease	7.9%
201	Congenital clubfoot	7.9%
202	Vertical Talus	7.9%
203	Homocystinuria	7.8%
204	Fetal Diseases	7.8%
205	Foot Diseases	7.8%
206	Granuloma Annulare	7.7%
207	Compartment syndromes	7.6%
208	Aortic Valve Insufficiency	7.6%
209	Restrictive cardiomyopathy	7.6%
210	Endocardial Fibroelastosis	7.6%
211	Heart Rupture, Post-Infarction	7.6%
212	Mitral Valve Insufficiency	7.6%
213	Mitral Valve Stenosis	7.6%
214	Myocarditis	7.6%
215	Pericarditis, Constrictive	7.6%
216	Pulmonary Valve Insufficiency	7.6%
217	Tricuspid Valve Insufficiency	7.6%
218	Tricuspid Valve Stenosis	7.6%
219	Ventricular Dysfunction, Left	7.6%
220	Right Ventricular Dysfunction	7.6%
221	Endomyocardial Fibrosis	7.6%
222	Carditis	7.6%
223	Heart Failure, Systolic	7.6%
224	Heart Failure, Diastolic	7.6%
225	Anophthalmos	7.6%
226	Anus, Imperforate	7.6%
227	Hydranencephaly	7.6%
228	Mesenteric Panniculitis	7.6%
229	Microphthalmos	7.6%
230	Neural Tube Defects	7.6%
231	Panniculitis, Peritoneal	7.6%
232	Tethered Cord Syndrome	7.6%
233	Orbital Cellulitis	7.6%
234	Iniencephaly	7.6%
235	Craniorachischisis	7.6%
236	Exencephaly	7.6%
237	Septo-Optic Dysplasia	7.6%
238	Cortical Dysplasia	7.6%
239	Myxoid cyst	7.6%
240	Malformations of Cortical Development	7.6%
241	Anorectal Malformations	7.6%
242	Bloom Syndrome	7.5%
243	Myxedema	7.5%
244	Angioedemas, Hereditary	7.5%
245	Coronary Occlusion	7.4%
246	Microvascular Angina	7.4%
247	Coronary Stenosis	7.4%
248	ST segment elevation myocardial infarction	7.4%
249	Retinal Dysplasia	7.4%
250	Aniridia	7.4%
251	Tachycardia, Atrioventricular Nodal Reentry	7.3%
252	Tachycardia, Ectopic Atrial	7.3%
253	Tachycardia, Ectopic Junctional	7.3%
254	Sinus Tachycardia	7.3%
255	Torsades de Pointes	7.3%
256	Accelerated Idioventricular Rhythm	7.3%
257	Felty Syndrome	7.3%
258	Dermatitis, Atopic	7.3%
259	Fragile X Syndrome	7.2%
260	Smith-Lemli-Opitz Syndrome	7.1%
261	Behcet Syndrome	6.9%
262	Albinism	6.9%
263	Cystic Fibrosis	6.8%
264	Basal Cell Nevus Syndrome	6.8%
265	Blepharophimosis	6.8%
266	Laryngostenosis	6.8%
267	Mouth Abnormalities	6.8%
268	Mucopolysaccharidosis II	6.7%
269	Esophageal Atresia	6.7%
270	Intestinal Atresia	6.7%
271	Horseshoe Kidney	6.7%
272	Embolism, Amniotic Fluid	6.7%
273	Aortic Aneurysm	6.7%
274	Aortitis	6.7%
275	Sinus Arrhythmia	6.7%
276	Atrial Fibrillation	6.7%
277	Atrial Flutter	6.7%
278	Edema, Cardiac	6.7%
279	Leriche Syndrome	6.7%
280	Lymphangiectasis, Intestinal	6.7%
281	Periphlebitis	6.7%
282	Phlebitis	6.7%
283	Thromboangiitis Obliterans	6.7%
284	Ventricular Fibrillation	6.7%
285	Pyoderma Gangrenosum	6.7%
286	Ventricular Flutter	6.7%
287	Porokeratosis	6.7%
288	Parasystole	6.7%
289	Paroxysmal atrial fibrillation	6.7%
290	Ischemic contracture	6.7%
291	Bradycardia	6.7%
292	Diabetic Cardiomyopathies	6.7%
293	Keratoderma, Palmoplantar	6.7%
294	Cardiomyopathy, Alcoholic	6.6%
295	Sudden Cardiac Death	6.6%
296	Left Ventricular Hypertrophy	6.6%
297	Right Ventricular Hypertrophy	6.6%
298	Chagas Cardiomyopathy	6.6%
299	Keloid	6.6%
300	Polyarteritis Nodosa	6.6%
301	Shock, Cardiogenic	6.6%
302	Takayasu Arteritis	6.6%
303	Angina, Unstable	6.6%
304	Retinal Vein Occlusion	6.4%
305	Angioedema	6.3%
306	Mucopolysaccharidosis III	6.2%
307	Primary Ciliary Dyskinesia	6.2%
308	Thrombophlebitis	6.2%
309	Meconium Aspiration Syndrome	6.2%
310	Coronary Restenosis	6.2%
311	Choanal Atresia	6.1%
312	Tracheobronchomegaly	6.1%
313	Laryngocele	6.1%
314	Classical Lissencephalies and Subcortical Band Heterotopias	6.1%
315	Choledochal Cyst	6.1%
316	Hermaphroditism	6.1%
317	Disorders of Sex Development	6.1%
318	Giant Cell Arteritis	6.1%
319	Temporal Arteritis	6.1%
320	Sicca Syndrome	6.1%
321	Sjogren's Syndrome	6.1%
322	Cryptorchidism	6%
323	Hypospadias	6%
324	Central Nervous System Cysts	6%
325	Subacute Bacterial Endocarditis	6%
326	Dandy-Walker Syndrome	6%
327	Aortic Rupture	6%
328	POEMS Syndrome	6%
329	Lupus Nephritis	5.9%
330	Dyspnea, Paroxysmal	5.9%
331	Shwartzman Phenomenon	5.9%
332	Multiple Epiphyseal Dysplasia	5.9%
333	Osteochondrodysplasias	5.9%
334	Postphlebitic Syndrome	5.8%
335	Lupus Vasculitis, Central Nervous System	5.8%
336	Aneurysm	5.8%
337	Angiomatosis	5.8%
338	Aortic Diseases	5.8%
339	Arterial Occlusive Diseases	5.8%
340	Hyperemia	5.8%
341	Hypotension	5.8%
342	Superior Vena Cava Syndrome	5.8%
343	Telangiectasis	5.8%
344	Vasculitis	5.8%
345	Venous Insufficiency	5.8%
346	Peripheral Vascular Diseases	5.8%
347	Embolism and Thrombosis	5.8%
348	Angiodysplasia	5.8%
349	Capillary Leak Syndrome	5.8%
350	Prehypertension	5.8%
351	Aortic Valve Prolapse	5.7%
352	Tricuspid Valve Prolapse	5.7%
353	Takotsubo Cardiomyopathy	5.7%
354	Moyamoya Disease	5.7%
355	Carotid Artery Thrombosis	5.6%
356	Noonan Syndrome	5.6%
357	Dermatitis, Phototoxic	5.5%
358	Pityriasis Lichenoides et Varioliformis Acuta	5.5%
359	Pityriasis Lichenoides	5.5%
360	Phototoxicity	5.5%
361	Bladder Exstrophy	5.5%
362	Epispadias	5.5%
363	Angina Pectoris, Variant	5.5%
364	Gout	5.5%
365	Multicystic Dysplastic Kidney	5.4%
366	Varicose Ulcer	5.4%
367	Zellweger Syndrome	5.4%
368	Dwarfism	5.3%
369	Klinefelter Syndrome	5.3%
370	Polycystic Kidney, Autosomal Dominant	5.2%
371	Kallmann Syndrome	5.2%
372	Mucocutaneous Lymph Node Syndrome	5.2%
373	Muscular Dystrophy	5.2%
374	Livedo Reticularis	5.2%
375	Vascular System Injuries	5.2%
376	Blue Toe Syndrome	5.2%
377	Intracranial Embolism and Thrombosis	5.1%
378	Carotid Stenosis	5.1%
379	Intracranial Aneurysm	5.1%
380	Papillon-Lefevre Disease	5.1%
381	Contracture	5.1%
382	Hepatic Veno-Occlusive Disease	5.1%
383	Osteoarthropathy, Secondary Hypertrophic	5.1%
384	Peliosis Hepatis	5.1%
385	Varicocele	5.1%
386	Fasciitis, Plantar	5.1%
387	Cerebrovascular Disorders	5%
388	Diabetic Angiopathies	5%
389	Reperfusion Injury	5%
390	Splenic Infarction	5%
391	Cerebrovascular Insufficiency	5%
392	Vascular Neoplasms	5%
393	Spinal Cord Vascular Diseases	5%
394	Vasoplegia	5%
395	Hemorrhoids	5%
396	Thoracic Outlet Syndrome	5%
397	Acne Vulgaris	5%
398	Anterior Compartment Syndrome	5%
399	Contact Dermatitis	5%
400	Eczema	5%
401	Erythema Multiforme	5%
402	Intertrigo	5%
403	Neurodermatitis	5%
404	Rhinophyma	5%
405	Perioral Dermatitis	5%
406	Acne	5%
407	Abdominal Compartment Syndrome	5%
408	Meningomyelocele	5%
409	Spina Bifida	5%
410	Muscular Dystrophy, Duchenne	5%
411	Aortic Aneurysm, Abdominal	5%
412	Aortic Aneurysm, Thoracic	5%
413	Sinus Arrest, Cardiac	5%
414	Dermatitis, Photoallergic	4.9%
415	Bone Diseases	4.9%
416	Fasciitis	4.9%
417	Foot Deformities	4.9%
418	Heart Diseases	4.9%
419	Arthropathy	4.9%
420	Vasculitis, Central Nervous System	4.9%
421	Myotonic Dystrophy	4.8%
422	Abdominal Cramps	4.8%
423	Amniotic Band Syndrome	4.8%
424	Asphyxia Neonatorum	4.8%
425	Infant, Premature, Diseases	4.8%
426	Infantile Colic	4.8%
427	Charcot-Marie-Tooth Disease	4.8%
428	Tuberous Sclerosis	4.7%
429	Ataxia Telangiectasia	4.6%
430	Leukomalacia, Periventricular	4.6%
431	Refsum Disease	4.6%
432	Hand-Arm Vibration Syndrome	4.6%
433	Foot Ulcer	4.6%
434	Arthritis, Psoriatic	4.5%
435	Fibromyalgia	4.5%
436	Optic Neuropathy, Ischemic	4.5%
437	Anterior Ischemic Optic Neuropathy	4.5%
438	Mesenteric vascular insufficiency	4.5%
439	Metatarsalgia	4.5%
440	Menkes Kinky Hair Syndrome	4.5%
441	Dermatitis Herpetiformis	4.5%
442	Sebaceous Gland Neoplasms	4.4%
443	Colitis, Ischemic	4.4%
444	Dental Enamel Hypoplasia	4.4%
445	Hypodontia	4.4%
446	Macrostomia	4.4%
447	Meningocele	4.4%
448	Microstomia	4.4%
449	Encephalocele	4.4%
450	Intracranial Arteriosclerosis	4.4%
451	Cerebral Atherosclerosis	4.4%
452	Cerebral Arteriosclerosis	4.4%
453	Jaw Diseases	4.4%
454	Myopathy	4.3%
455	Neoplastic Syndromes, Hereditary	4.3%
456	Anemia, Neonatal	4.2%
457	Pelger-Huet Anomaly	4.2%
458	Persistent Fetal Circulation Syndrome	4.2%
459	Werner Syndrome	4.2%
460	Myasthenic Syndromes, Congenital	4.2%
461	Hyperandrogenism	4.2%
462	Umbilical hernia	4.2%
463	Dermatitis, Irritant	4.1%
464	Acne Conglobata	4.1%
465	Diabetic Foot	4.1%
466	Osteoarthritis, Spine	4.1%
467	Toxic Epidermal Necrolysis	4.1%
468	Stevens-Johnson Syndrome	4.1%
469	Urticaria Pigmentosa	4%
470	Porphyrias, Hepatic	4%
471	Cerebral Thrombosis	4%
472	Intracranial Embolism	4%
473	Intracranial Thrombosis	4%
474	Temporomandibular Joint Disorders	4%
475	Subarachnoid Hemorrhage, Traumatic	4%
476	Carotid Artery, Internal, Dissection	4%
477	Lemierre Syndrome	4%
478	Anemia, Sickle Cell	4%
479	Thalassemia	4%
480	Gonadal Dysgenesis	4%
481	Adrenogenital Syndrome	4%
482	Ovotesticular Disorders of Sex Development	4%
483	Congenital Hypothyroidism	4%
484	Brain Infarction	3.9%
485	Arthritis, Gouty	3.9%
486	Kearns-Sayre syndrome	3.9%
487	Breast Diseases	3.8%
488	Dermatitis	3.8%
489	Exanthema	3.8%
490	Facial Dermatoses	3.8%
491	Hair Diseases	3.8%
492	Hand Dermatoses	3.8%
493	keratoacanthoma	3.8%
494	Keratosis	3.8%
495	Nail Diseases	3.8%
496	Photosensitivity Disorders	3.8%
497	Prurigo	3.8%
498	Pyoderma	3.8%
499	Rosacea	3.8%
500	Sebaceous Gland Diseases	3.8%
501	Skin Diseases, Vesiculobullous	3.8%
502	Skin Ulcer	3.8%
503	Sweat Gland Diseases	3.8%
504	Skin Diseases, Papulosquamous	3.8%
505	Skin Diseases, Vascular	3.8%
506	Acneiform Eruptions	3.8%
507	Ocular Rosacea	3.8%
508	Subcorneal pustular dermatosis	3.8%
509	Erythematotelangiectatic Rosacea	3.8%
510	Papulopustular Rosacea	3.8%
511	Chronic Actinic Dermatitis	3.8%
512	Aneurysm, Dissecting	3.8%
513	Arteriosclerosis	3.8%
514	Arteritis	3.8%
515	Embolism	3.8%
516	Erythromelalgia	3.8%
517	Fibromuscular Dysplasia	3.8%
518	Malignant Hypertension	3.8%
519	Raynaud Disease	3.8%
520	Thromboembolism	3.8%
521	Thrombosis	3.8%
522	Essential Hypertension	3.8%
523	Aneurysm, Ruptured	3.8%
524	Iliac Aneurysm	3.8%
525	Pulmonary artery stenosis	3.8%
526	White Coat Hypertension	3.8%
527	Systemic Vasculitis	3.8%
528	Embolus	3.8%
529	Neonatal Abstinence Syndrome	3.8%
530	Craniofacial Abnormalities	3.8%
531	Infarction, Middle Cerebral Artery	3.8%
532	Infarction, Anterior Cerebral Artery	3.8%
533	Infarction, Posterior Cerebral Artery	3.8%
534	Dermatitis, Occupational	3.8%
535	Hereditary Angioedema Type III	3.7%
536	Hereditary Angioedema Types I and II	3.7%
537	Fetal Growth Retardation	3.7%
538	Temporomandibular Joint Dysfunction Syndrome	3.7%
539	Rheumatic Fever	3.7%
540	Fetal Hypoxia	3.7%
541	Congenital nystagmus	3.7%
542	Fetal Alcohol Spectrum Disorders	3.7%
543	Dermal Sinus	3.7%
544	Spina Bifida Cystica	3.7%
545	Spina Bifida Occulta	3.7%
546	Lissencephaly	3.7%
547	Polymicrogyria	3.7%
548	Pachygyria	3.7%
549	Schizencephaly	3.7%
550	Periventricular Nodular Heterotopia	3.7%
551	Diaper Rash	3.7%
552	Toxoplasmosis, Congenital	3.7%
553	Syphilis, Congenital	3.7%
554	Erythema Infectiosum	3.7%
555	Dermatitis, Allergic Contact	3.7%
556	Exanthema Subitum	3.7%
557	Erythema Nodosum	3.6%
558	Vertebral Artery Dissection	3.6%
559	Fabry Disease	3.5%
560	Sinus Thrombosis, Intracranial	3.5%
561	Tinea Capitis	3.5%
562	Onychomycosis	3.5%
563	Peutz-Jeghers Syndrome	3.4%
564	Skin Diseases, Infectious	3.4%
565	Skin Neoplasms	3.4%
566	Pigmentation Disorders	3.4%
567	Autoimmune Lymphoproliferative Syndrome	3.4%
568	Lipomatosis	3.4%
569	Pruritus	3.4%
570	Retinal Artery Occlusion	3.4%
571	Erythema	3.4%
572	Retinal Vasculitis	3.4%
573	Hypertensive Retinopathy	3.4%
574	Necrolytic Migratory Erythema	3.4%
575	Cutaneous Fistula	3.4%
576	Nephrogenic Fibrosing Dermopathy	3.4%
577	Nephrogenic Systemic Fibrosis	3.4%
578	Congenital Hyperinsulinism	3.4%
579	Chorioamnionitis	3.3%
580	Hip Contracture	3.3%
581	Familial Periodic Paralysis	3.3%
582	Periarthritis	3.3%
583	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
584	Gastric Antral Vascular Ectasia	3.3%
585	Myotonia Congenita	3.3%
586	Carotid Artery Diseases	3.3%
587	Brain Ischemia	3.3%
588	Hypotension, Orthostatic	3.3%
589	Cerebrovascular accident	3.3%
590	Vasospasm, Intracranial	3.3%
591	Spinal Cord Ischemia	3.3%
592	Intracranial Arterial Diseases	3.3%
593	Primary Graft Dysfunction	3.3%
594	Post-Exercise Hypotension	3.3%
595	Wiskott-Aldrich Syndrome	3.3%
596	Ecthyma	3.3%
597	Welander Distal Myopathy	3.3%
598	Carotid Artery Injuries	3.3%
599	Cerebral Infarction	3.3%
600	Brain Stem Infarctions	3.3%
601	Ankylosing spondylitis	3.2%
602	Cavernous Sinus Thrombosis	3.2%
603	Sagittal Sinus Thrombosis	3.2%
604	Hidradenitis Suppurativa	3%
605	Mesenteric Vascular Occlusion	3%
606	Basal Ganglia Hemorrhage	3%
607	Diabetic Retinopathy	3%
608	Mastocytosis	3%
609	Sturge-Weber Syndrome	3%
610	Variegate Porphyria	3%
611	Acute intermittent porphyria	3%
612	Porphyria Cutanea Tarda	3%
613	Gigantism	3%
614	Spinal Neoplasms	3%
615	Spondylitis	3%
616	Renal hypertension	3%
617	Renal Artery Obstruction	3%
618	Renal Artery Stenosis	3%
619	Hemangioma, Cavernous	2.9%
620	Basal Ganglia Cerebrovascular Disease	2.9%
621	Vascular Headaches	2.9%
622	Scurvy	2.9%
623	Lateral Medullary Syndrome	2.9%
624	Rett Syndrome	2.9%
625	Osteoarthritis, Knee	2.9%
626	Arthritis	2.9%
627	Bone Diseases, Developmental	2.9%
628	Bursitis	2.9%
629	Hyperostosis	2.9%
630	Joint Instability	2.9%
631	Myofascial Pain Syndromes	2.9%
632	Osteitis	2.9%
633	Osteitis Deformans	2.9%
634	Osteochondrosis	2.9%
635	Rhabdomyolysis	2.9%
636	Spinal Diseases	2.9%
637	Synovitis	2.9%
638	Joint laxity	2.9%
639	Polyarthritis	2.9%
640	Frozen shoulder	2.9%
641	Patellofemoral Pain Syndrome	2.9%
642	Anhidrosis	2.9%
643	Cholesteatoma	2.9%
644	Pressure Ulcer	2.9%
645	Folliculitis	2.9%
646	Foot Dermatoses	2.9%
647	Gynecomastia	2.9%
648	Hypertrichosis	2.9%
649	Hypohidrosis	2.9%
650	Hypotrichosis	2.9%
651	Leg Ulcer	2.9%
652	Miliaria	2.9%
653	Parakeratosis	2.9%
654	Parapsoriasis	2.9%
655	Familial Mediterranean Fever	2.9%
656	Pityriasis	2.9%
657	Psoriasis	2.9%
658	Sweet Syndrome	2.9%
659	Hidradenitis	2.9%
660	Onycholysis	2.9%
661	Miliaria Rubra	2.9%
662	Hyperpigmentation	2.9%
663	Lichenoid Eruptions	2.9%
664	Chloracne	2.9%
665	Arteriosclerosis Obliterans	2.8%
666	Atherosclerosis	2.8%
667	Air Embolism	2.8%
668	Endarteritis	2.8%
669	Venous Thrombosis	2.8%
670	Deep Vein Thrombosis	2.8%
671	Venous Thromboembolism	2.8%
672	Tinea Pedis	2.8%
673	MELAS Syndrome	2.8%
674	Adrenoleukodystrophy	2.8%
675	Erythema Chronicum Migrans	2.8%
676	Ophthalmia Neonatorum	2.7%
677	Hepatolenticular Degeneration	2.7%
678	Neuronal Ceroid-Lipofuscinoses	2.7%
679	Cryoglobulinemia	2.6%
680	Sickle Cell Trait	2.6%
681	Bone Diseases, Endocrine	2.6%
682	Putaminal Hemorrhage	2.6%
683	Arthritis, Reactive	2.5%
684	Bone Diseases, Infectious	2.5%
685	Bone neoplasms	2.5%
686	Maxillary Diseases	2.5%
687	Osteopenia	2.5%
688	Tendinitis	2.5%
689	Tendinopathy	2.5%
690	Mycetoma	2.5%
691	Amyloid Neuropathies, Familial	2.5%
692	Acantholysis	2.5%
693	Bone Resorption	2.5%
694	Breast Cyst	2.5%
695	Hemarthrosis	2.5%
696	Actinic keratosis	2.5%
697	Myositis	2.5%
698	Paralysis, Obstetric	2.5%
699	Pemphigoid, Benign Mucous Membrane	2.5%
700	Pemphigus	2.5%
701	Piedra	2.5%
702	Retinopathy of Prematurity	2.5%
703	Sunburn	2.5%
704	Isaacs syndrome	2.5%
705	Aseptic Necrosis of Bone	2.5%
706	Myotonic Disorders	2.5%
707	Dementia, Vascular	2.5%
708	Intermittent Claudication	2.5%
709	Pulmonary Embolism	2.5%
710	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.5%
711	Amino Acid Metabolism, Inborn Errors	2.5%
712	Argyria	2.5%
713	Carbohydrate Metabolism, Inborn Errors	2.5%
714	Hirsutism	2.5%
715	Lactation Disorder	2.5%
716	Mastitis	2.5%
717	Metal Metabolism, Inborn Errors	2.5%
718	Progeria	2.5%
719	Urticaria	2.5%
720	Lysosomal Storage Diseases	2.5%
721	Cytochrome-c Oxidase Deficiency	2.5%
722	Peroxisomal Disorders	2.5%
723	Adiposis Dolorosa	2.5%
724	Bronchopulmonary Dysplasia	2.5%
725	Pruritus Vulvae	2.5%
726	No-Reflow Phenomenon	2.5%
727	Mastocytoma	2.5%
728	Pruritus Ani	2.5%
729	Cerebral Arterial Diseases	2.5%
730	Vertebrobasilar Insufficiency	2.5%
731	Anterior Spinal Artery Syndrome	2.5%
732	Basilar Artery Stenosis	2.5%
733	Vertebral Artery Stenosis	2.5%
734	Intracranial Hemorrhage, Hypertensive	2.5%
735	Transient Cerebral Ischemia	2.5%
736	Pseudohypoparathyroidism	2.4%
737	Shy-Drager Syndrome	2.4%
738	Purpura, Hyperglobulinemic	2.4%
739	Lichen Planus	2.4%
740	Melanosis	2.4%
741	Chloasma	2.4%
742	Pityriasis Rosea	2.4%
743	Pityriasis Rubra Pilaris	2.4%
744	Vitiligo	2.4%
745	Lichen Nitidus	2.4%
746	Denys-Drash Syndrome	2.3%
747	Hypokalemic periodic paralysis	2.3%
748	Hydrops Fetalis	2.3%
749	Spondylarthropathies	2.3%
750	Respiratory Distress Syndrome, Newborn	2.3%
751	Medial Tibial Stress Syndrome	2.3%
752	Dermatomycoses	2.2%
753	Skin Diseases, Bacterial	2.2%
754	Mitochondrial Myopathies	2.2%
755	Muscle Cramp	2.2%
756	Retinitis Pigmentosa	2.2%
757	Eosinophilia-Myalgia Syndrome	2.2%
758	Pigmentary retinopathy	2.2%
759	Drug Eruptions	2.2%
760	Lipodystrophy	2.2%
761	Muscle Rigidity	2.2%
762	Muscle Spasticity	2.2%
763	Cogwheel Rigidity	2.2%
764	Nuchal Rigidity	2.2%
765	Acute Chest Syndrome	2.2%
766	Chronic granulomatous disease	2.2%
767	Waldenstrom Macroglobulinemia	2.2%
768	Multiple Myeloma	2.2%
769	Discitis	2.2%
770	Hypertension, Renovascular	2.2%
771	Subarachnoid Hemorrhage	2.2%
772	Hypoxia-Ischemia, Brain	2.2%
773	Cerebral Hemorrhage	2.2%
774	Galactosemias	2.2%
775	Urea Cycle Disorders, Inborn	2.2%
776	Tyrosinemias	2.2%
777	Acanthosis Nigricans	2.1%
778	Alopecia Areata	2.1%
779	Lentigo	2.1%
780	Canavan Disease	2.1%
781	Alexander Disease	2.1%
782	Alopecia	2.1%
783	Sweating, Gustatory	2.1%
784	Androgenetic Alopecia	2.1%
785	Auriculotemporal Syndrome	2.1%
786	Hepatic Vein Thrombosis	2.1%
787	Budd-Chiari Syndrome	2.1%
788	Glycogen storage disease type II	2.1%
789	Lice Infestations	2.1%
790	Breast Neoplasms, Male	2.1%
791	Triple Negative Breast Neoplasms	2.1%
792	Pulmonary Infarction	2.1%
793	Chronic Fatigue Syndrome	2.1%
794	Galactorrhea	2.1%
795	Subclavian Steal Syndrome	2.1%
796	Duane Retraction Syndrome	2%
797	Optic Atrophy, Hereditary, Leber	2%
798	Giant Cell Epulis	2%
799	Muscle Weakness	2%
800	Hyperphosphaturia	2%
801	Musculoskeletal Pain	2%
802	Arthralgia	2%
803	Thrombasthenia	2%
804	Polyarthralgia	2%
805	Antithrombin III Deficiency	2%
806	Protein C Deficiency	2%
807	Brain Diseases, Metabolic, Inborn	2%
808	Afibrinogenemia	2%
809	Dystonia Musculorum Deformans	2%
810	Factor VII Deficiency	2%
811	Factor X Deficiency	2%
812	Factor XII Deficiency	2%
813	Hemophilia A	2%
814	Pituitary Apoplexy	2%
815	Activated Protein C Resistance	2%
816	Factor II deficiency	2%
817	Factor VIII Deficiency	2%
818	Factor V deficiency	2%
819	Factor XI Deficiency	2%
820	Hypoprothrombinemias	2%
821	Fanconi Anemia	2%
822	Nesidioblastosis	2%
823	Lafora Disease	2%
824	Unverricht-Lundborg Syndrome	2%
825	Anemia, Diamond-Blackfan	2%
826	Tuberculosis, Spinal	2%
827	Ainhum	1.9%
828	Bunion	1.9%
829	Dysostoses	1.9%
830	Fibrodysplasia Ossificans Progressiva	1.9%
831	Myoglobinuria	1.9%
832	Myositis Ossificans	1.9%
833	Spinal Stenosis	1.9%
834	Spondylosis	1.9%
835	Tenosynovitis	1.9%
836	Intervertebral Disc Degeneration	1.9%
837	Sacroiliitis	1.9%
838	Lichen Planus, Oral	1.9%
839	Larva Migrans	1.9%
840	Leishmaniasis	1.9%
841	Molluscum Contagiosum	1.9%
842	Multiple Endocrine Neoplasia	1.9%
843	Onchocerciasis	1.8%
844	Granulomatosis with polyangiitis	1.8%
845	Chromoblastomycosis	1.8%
846	Dermatophytosis	1.8%
847	Sporotrichosis	1.8%
848	Tinea	1.8%
849	Tinea Versicolor	1.8%
850	Trichophytosis	1.8%
851	Hyalohyphomycosis	1.8%
852	Acute Generalized Exanthematous Pustulosis	1.8%
853	Cerebral Amyloid Angiopathy	1.8%
854	Eosinophilic Granuloma	1.8%
855	Myalgia	1.8%
856	Palatal Neoplasms	1.8%
857	Leigh Disease	1.8%
858	Warts	1.7%
859	Arthritis, Infectious	1.7%
860	Kernicterus	1.7%
861	Osteomyelitis	1.7%
862	Osteoporosis	1.7%
863	Periostitis	1.7%
864	Enthesopathy	1.7%
865	Bone Demineralization, Pathologic	1.7%
866	Post-Traumatic Osteoporosis	1.7%
867	Arthritis, Experimental	1.7%
868	Alveolar Bone Loss	1.7%
869	Femur Head Necrosis	1.7%
870	Polymyositis	1.7%
871	Osteolysis	1.7%
872	Candidiasis, Chronic Mucocutaneous	1.7%
873	Cutaneous Candidiasis	1.7%
874	Alkaptonuria	1.7%
875	Glycogen Storage Disease	1.7%
876	Hypophosphatasia	1.7%
877	Propionic acidemia	1.7%
878	Dihydropyrimidine Dehydrogenase Deficiency	1.7%
879	Cystinosis	1.7%
880	Leishmaniasis, Cutaneous	1.7%
881	Eczema Herpeticum	1.7%
882	Erysipelas	1.7%
883	Serum Sickness	1.7%
884	Staphylococcal Skin Infections	1.7%
885	Erythrasma	1.6%
886	Carcinoma, Lobular	1.6%
887	Fusariosis	1.6%
888	Gaucher Disease	1.6%
889	Huntington Disease	1.5%
890	Familial Hypophosphatemic Rickets	1.5%
891	Hip Dislocation	1.5%
892	Shoulder Dislocation	1.5%
893	Hip Dysplasia	1.5%
894	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.5%
895	Epidermodysplasia Verruciformis	1.5%
896	Herpes Labialis	1.5%
897	Orbital Myositis	1.5%
898	Hyaline Membrane Disease	1.5%
899	Pyomyositis	1.5%
900	Staphylococcal Scalded Skin Syndrome	1.5%
901	Acromegaly	1.5%
902	Joint Tuberculosis	1.5%
903	Tuberculosis, Osteoarticular	1.5%
904	Bone Tuberculosis	1.5%
905	Hypolipoproteinemias	1.5%
906	Hyperlipidemia, Familial Combined	1.5%
907	Hyperlipoproteinemia Type III	1.5%
908	Chondrodysplasia Punctata	1.4%
909	Enchondromatosis	1.4%
910	Lordosis	1.4%
911	Osteosclerosis	1.4%
912	Spondylolysis	1.4%
913	kyphosis	1.4%
914	Kashin-Beck Disease	1.4%
915	Nephroblastoma	1.4%
916	carbuncle	1.4%
917	Blastomycosis	1.4%
918	HIV-Associated Lipodystrophy Syndrome	1.4%
919	Tay-Sachs Disease	1.4%
920	Hematoma, Subdural	1.4%
921	Hematoma, Epidural, Cranial	1.4%
922	Niemann-Pick Disease, Type C	1.4%
923	Condylomata Acuminata	1.4%
924	Furunculosis	1.3%
925	furuncle	1.3%
926	Impetigo	1.3%
927	Rickets	1.3%
928	Lactose Intolerance	1.3%
929	Hyperhomocysteinemia	1.3%
930	Renal Aminoacidurias	1.3%
931	Fanconi Syndrome	1.3%
932	Pseudohypoaldosteronism	1.3%
933	Shoulder Pain	1.3%
934	Liddle Syndrome	1.3%
935	Hyperlipoproteinemia Type IV	1.3%
936	Hyperlipoproteinemia Type V	1.3%
937	Adenomatous Polyposis Coli	1.3%
938	Rhinoscleroma	1.3%
939	Brain Hemorrhage, Traumatic	1.3%
940	Osteoporosis, Postmenopausal	1.2%
941	Glycogen Storage Disease Type I	1.2%
942	Glycogen Storage Disease Type V	1.2%
943	Hematoma, Subdural, Intracranial	1.2%
944	Hematoma, Subdural, Chronic	1.2%
945	Hematoma, Subdural, Acute	1.2%
946	Multiple Endocrine Neoplasia Type 1	1.2%
947	Mitochondrial Encephalomyopathies	1.2%
948	Friedreich Ataxia	1.2%
949	Renal tubular acidosis	1.2%
950	Melorheostosis	1.2%
951	Osteopetrosis	1.2%
952	Spondylolisthesis	1.2%
953	Mastoiditis	1.1%
954	Petrositis	1.1%
955	Hypoalphalipoproteinemias	1.1%
956	Glycosuria, Renal	1%
957	Osteomalacia	1%
958	Cystinuria	1%
959	Nose Neoplasms	0.8%
960	Renal Osteodystrophy	0.8%
961	Renal rickets	0.8%
962	Radicular Cyst	0.7%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234