MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Encephalomyelitis, Acute Disseminated

(UMLS:C0014059)

Definition:: An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
UMLS ID:: C0014059
MeSH ID:: D004673

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.114.375.225|C10.228.140.695.562.225|C10.314.350.225

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.258.250.350

Synonym(s)

Encephalomyelitis, Acute Disseminated

ADEM

ADEM - Acute disseminated encephalomyelitis

Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis

MYELINOCLASIS, PERIVASCULAR, ACUTE

acute disseminated encephalomyelitis

acute; disseminated encephalomyelitis

encephalomyelitis; acute disseminated

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cocaine	17288929	CTD
2	Methylprednisolone	16266628	CTD
3	Morphine	16971632	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Neuromyelitis Optica	48.9%
2	Multiple Sclerosis	46.4%
3	Leukoencephalitis, Acute Hemorrhagic	40.1%
4	Polyradiculoneuropathy	35.7%
5	Polyradiculoneuritis	35.7%
6	Myelitis, Transverse	35.6%
7	Stiff-Person Syndrome	34.2%
8	Multiple Sclerosis, Chronic Progressive	34%
9	Multiple Sclerosis, Relapsing-Remitting	34%
10	Myasthenia Gravis	28.5%
11	Marchiafava-Bignami Disease	24.8%
12	Guillain-Barre Syndrome	24.5%
13	Multiple System Atrophy	24.4%
14	Vasculitis, Central Nervous System	24.3%
15	Meningoencephalitis	23.7%
16	Myasthenia Gravis, Autoimmune, Experimental	23.7%
17	Uveomeningoencephalitic Syndrome	23.5%
18	Lambert-Eaton Myasthenic Syndrome	23.4%
19	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	23.3%
20	Encephalomyelitis	22.7%
21	Subacute Combined Degeneration	22.4%
22	Posterior Leukoencephalopathy Syndrome	21.9%
23	Posterior reversible encephalopathy syndrome	21.9%
24	Myelinolysis, Central Pontine	21.3%
25	Leukoencephalopathy, Progressive Multifocal	21.1%
26	Miller Fisher Syndrome	21%
27	Dementia, Vascular	20.9%
28	Ophthalmoplegic Migraine	20.9%
29	Ocular Motility Disorders	20.7%
30	Cyclophoria	20.7%
31	Lupus Vasculitis, Central Nervous System	20.5%
32	Dandy-Walker Syndrome	20.4%
33	Pneumocephalus	20.3%
34	Lewy Body Disease	20.3%
35	Subdural Effusion	19.6%
36	Cranial nerve diseases	19.5%
37	Neuromuscular Diseases	19.5%
38	Chronobiology Disorders	19.5%
39	Motor Neuron Disease	18.5%
40	Parkinson Disease	18.3%
41	Prion Diseases	17.7%
42	Parkinsonian Disorders	17.4%
43	Restless Legs Syndrome	17.3%
44	Amyotrophic Lateral Sclerosis	17.2%
45	Spinal Muscular Atrophy	17.2%
46	Progressive Muscular Atrophy	17.2%
47	Progressive supranuclear palsy	17.1%
48	Myelitis	17%
49	Brain Abscess	17%
50	Epidural Abscess	17%
51	Meningitis	16.9%
52	Movement Disorders	16.9%
53	Pachymeningitis	16.9%
54	Spinal Cord Diseases	16.9%
55	Brain Injuries	16.9%
56	Brain Neoplasms	16.9%
57	Akinetic Mutism	16.7%
58	Anoxic Encephalopathy	16.7%
59	Basal Ganglia Diseases	16.7%
60	Brain Damage, Chronic	16.7%
61	Cerebellar Diseases	16.7%
62	Encephalitis	16.7%
63	Encephalomalacia	16.7%
64	Epilepsy	16.7%
65	Hydrocephalus	16.7%
66	Congenital Hydrocephalus	16.7%
67	Hypothalamic Diseases	16.7%
68	Thalamic Diseases	16.7%
69	Intracranial Hypertension	16.7%
70	Aura	16.7%
71	Neuroaxonal Dystrophies	16.7%
72	Headache Disorders	16.7%
73	Intracranial Hypotension	16.7%
74	Brain Edema	16.7%
75	Brain Hypoxia	16.7%
76	Aqueductal Stenosis	16.7%
77	Trauma, Nervous System	16.7%
78	Striatonigral Degeneration	16.5%
79	Epilepsy, Post-Traumatic	16.4%
80	Nervous System Neoplasms	16.3%
81	Neurologic Manifestations	16.3%
82	Neurotoxicity Syndromes	16.3%
83	Neuritis, Autoimmune, Experimental	16.3%
84	Canavan Disease	15.9%
85	Alexander Disease	15.9%
86	Spinal Cord Injuries	15.6%
87	Neuroleptic Malignant Syndrome	15.6%
88	Poliomyelitis	15.4%
89	Basal Ganglia Cerebrovascular Disease	15.4%
90	Dystonia Musculorum Deformans	15.3%
91	Huntington Disease	15.3%
92	Asterixis	15.2%
93	Ballismus	15.2%
94	Autonomic Dysreflexia	15%
95	Complex Regional Pain Syndromes	15%
96	Shy-Drager Syndrome	14.7%
97	Meige Syndrome	14.6%
98	Cerebral Ventriculitis	14.6%
99	Central Nervous System Infection	14.6%
100	Brain Death	14.4%
101	Sleep Wake Disorders	14.2%
102	Brain Diseases, Metabolic	14.1%
103	Cerebrovascular Disorders	14.1%
104	Cerebrovascular Insufficiency	14.1%
105	Dementia	14.1%
106	MPTP Poisoning	14.1%
107	Cerebellar Neoplasms	13.9%
108	Chronic Fatigue Syndrome	13.8%
109	Limbic Encephalitis	13.6%
110	Amblyopia	13.6%
111	Leukomalacia, Periventricular	13.5%
112	Vascular Headaches	13.3%
113	Opsoclonus-Myoclonus Syndrome	13.2%
114	Hypoxia-Ischemia, Brain	13.2%
115	Giant Cell Arteritis	13.2%
116	Temporal Arteritis	13.2%
117	Peripheral Nerve Injuries	12.9%
118	Myoclonic Epilepsy	12.9%
119	Epilepsy, Temporal Lobe	12.9%
120	Epilepsy, Rolandic	12.9%
121	Benign Rolandic Epilepsy	12.9%
122	Presenile dementia	12.6%
123	Senile dementia	12.6%
124	Demyelinating Diseases	12.6%
125	Demyelination	12.6%
126	Creutzfeldt-Jakob disease	12.6%
127	Dyskinesia, Drug-Induced	12.5%
128	Spinal Cord Neoplasms	12.2%
129	Meningitis, Bacterial	12.2%
130	Meningitis, Fungal	12.2%
131	Brain Hemorrhage, Traumatic	12.1%
132	Hepatolenticular Degeneration	11.9%
133	Causalgia	11.9%
134	Akathisia, Drug-Induced	11.9%
135	Olfactory Nerve Injuries	11.7%
136	Sleep Disorders, Circadian Rhythm	11.5%
137	Progressive bulbar palsy	11.5%
138	Bulbar palsy	11.5%
139	Amnesia, Transient Global	11.4%
140	Lafora Disease	11.3%
141	Unverricht-Lundborg Syndrome	11.3%
142	Carotid Artery Injuries	11.2%
143	Botulism	11.2%
144	Central Nervous System Cysts	11.2%
145	Brain Injuries, Diffuse	11.1%
146	Traumatic Brain Injury	11.1%
147	Cerebellar Ataxia	11.1%
148	Supratentorial Neoplasms	11.1%
149	Ataxia Telangiectasia	11.1%
150	Paraneoplastic Cerebellar Degeneration	11%
151	Dysautonomia	11%
152	Vagus Nerve Disorder	11%
153	Glossopharyngeal Neuralgia	11%
154	Abducens Nerve Diseases	11%
155	Heavy Metal Poisoning, Nervous System	11%
156	Neuromuscular Junction Diseases	11%
157	Tauopathies	11%
158	Trochlear Nerve Diseases	11%
159	Peripheral Nervous System Diseases	11%
160	Basal Ganglia Hemorrhage	10.8%
161	Friedreich Ataxia	10.8%
162	Cerebral Palsy	10.7%
163	Epilepsies, Partial	10.7%
164	Epilepsy, Generalized	10.7%
165	Pseudotumor Cerebri	10.7%
166	Hypertensive Encephalopathy	10.7%
167	Simple Partial Seizures	10.7%
168	Epilepsy, Reflex	10.7%
169	Headache Disorders, Primary	10.7%
170	Headache Disorders, Secondary	10.7%
171	Medication overuse headache	10.7%
172	Adrenoleukodystrophy	10.7%
173	Pituitary Adenoma	10.6%
174	Pituitary Neoplasms	10.6%
175	Juvenile Myoclonic Epilepsy	10.5%
176	Myoclonic Epilepsies, Progressive	10.5%
177	Facial Nerve Injuries	10.4%
178	Persistent Vegetative State	10.4%
179	Toxoplasmosis, Cerebral	10.3%
180	Arachnoiditis	10.2%
181	Aseptic Meningitis	10.2%
182	Syringomyelia	10.2%
183	Essential Tremor	10.2%
184	Familial Tremor	10.2%
185	Pneumorrhachis	10.2%
186	Writer's Cramp	10.2%
187	Antiphospholipid Syndrome	10%
188	Scrapie	9.9%
189	Central Cord Syndrome	9.9%
190	Horner Syndrome	9.9%
191	Pituitary Apoplexy	9.8%
192	Reflex Sympathetic Dystrophy	9.8%
193	Nocturnal Myoclonus Syndrome	9.8%
194	Chorea	9.8%
195	Brain Infarction	9.7%
196	Tuberculosis, Meningeal	9.5%
197	Myopathy	9.5%
198	Optic Neuropathy	9.5%
199	Pituitary Diseases	9.3%
200	Facial Nerve Diseases	9.2%
201	Craniocerebral Trauma	9.2%
202	Parasomnia	9.2%
203	Dyssomnias	9.2%
204	Vestibulocochlear Nerve Diseases	9.1%
205	Decerebrate State	9.1%
206	Hemiparesis	9.1%
207	Hydranencephaly	9.1%
208	Meningism	9.1%
209	Neural Tube Defects	9.1%
210	Paresis	9.1%
211	Seizures	9.1%
212	Sensation Disorders	9.1%
213	Tethered Cord Syndrome	9.1%
214	Central Nervous System Neoplasms	9.1%
215	Complex partial seizures	9.1%
216	Iniencephaly	9.1%
217	Craniorachischisis	9.1%
218	Exencephaly	9.1%
219	Monoparesis	9.1%
220	Septo-Optic Dysplasia	9.1%
221	Cortical Dysplasia	9.1%
222	Neurogenic Inflammation	9.1%
223	Gait Disorders, Neurologic	9.1%
224	Neuromuscular Manifestations	9.1%
225	Malformations of Cortical Development	9.1%
226	Sweating, Gustatory	9.1%
227	Auriculotemporal Syndrome	9.1%
228	Carotid Artery Diseases	9%
229	Brain Ischemia	9%
230	Cerebrovascular accident	9%
231	Kluver-Bucy Syndrome	9%
232	Vasospasm, Intracranial	9%
233	Intracranial Arterial Diseases	9%
234	Putaminal Hemorrhage	9%
235	Tuberous Sclerosis	8.9%
236	Jet Lag Syndrome	8.8%
237	Mitochondrial Encephalomyopathies	8.7%
238	Ophthalmoplegia	8.7%
239	External Ophthalmoplegia	8.7%
240	Charcot-Marie-Tooth Disease	8.7%
241	Infarction, Middle Cerebral Artery	8.6%
242	Infarction, Anterior Cerebral Artery	8.6%
243	Infarction, Posterior Cerebral Artery	8.6%
244	Central Nervous System Fungal Infections	8.6%
245	Conus Medullaris Syndrome	8.6%
246	Spinal Cord Vascular Diseases	8.6%
247	Lupus Erythematosus, Systemic	8.4%
248	Overlap syndrome	8.4%
249	Acrodynia	8.4%
250	Torticollis	8.3%
251	Addison Disease	8.3%
252	Pemphigus	8.3%
253	Autoimmune thyroiditis	8.3%
254	Primary Adrenal Insufficiency	8.3%
255	Diffuse Axonal Injury	8.3%
256	Brain Stem Neoplasms	8.3%
257	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	8.3%
258	Autoimmune hepatitis	8.3%
259	Brain Concussion	8.3%
260	Vertebral Artery Dissection	8.2%
261	Brachial Plexus Neuritis	8.1%
262	Neuralgic Amyotrophy	8.1%
263	Pupil Disorders	8.1%
264	Neurobehavioral Manifestations	8.1%
265	Alice in Wonderland Syndrome	8%
266	Brain Diseases	8%
267	Paraneoplastic Encephalomyelitis	7.9%
268	Subarachnoid Hemorrhage, Traumatic	7.9%
269	Carotid Artery, Internal, Dissection	7.9%
270	Frontotemporal dementia	7.9%
271	Cerebral Infarction	7.8%
272	Brain Stem Infarctions	7.8%
273	Auditory Perceptual Disorders	7.8%
274	Moyamoya Disease	7.8%
275	Sturge-Weber Syndrome	7.8%
276	Vertigo	7.8%
277	Alcohol-Induced Disorders, Nervous System	7.8%
278	Post-Traumatic Headache	7.8%
279	Tension Headache	7.8%
280	Vocal Cord Paralysis	7.8%
281	Epilepsy, Complex Partial	7.8%
282	Migraine Disorders	7.8%
283	Abdominal Migraine	7.8%
284	Status Migrainosus	7.8%
285	Cervicogenic Headache	7.8%
286	Refsum Disease	7.8%
287	Reye Syndrome	7.7%
288	Intracranial Embolism and Thrombosis	7.7%
289	Hepatic Encephalopathy	7.7%
290	Subacute Sclerosing Panencephalitis	7.7%
291	Autoimmune Lymphoproliferative Syndrome	7.5%
292	Meningitis, Cryptococcal	7.5%
293	Meningitis, Listeria	7.5%
294	Meningitis, Haemophilus	7.5%
295	Meningitis, Pneumococcal	7.5%
296	MELAS Syndrome	7.4%
297	Central Nervous System Bacterial Infections	7.4%
298	Myotonia Congenita	7.4%
299	Coma, Post-Head Injury	7.4%
300	Encephalomyelitis, Acute Disseminated	7.3%
301	Cerebrospinal Fluid Otorrhea	7.3%
302	Cerebrospinal Fluid Rhinorrhea	7.3%
303	Gait Ataxia	7.3%
304	Tarsal Tunnel Syndrome	7.3%
305	Cauda Equina Syndrome	7.3%
306	Brain Contusion	7.3%
307	Latent Autoimmune Diabetes in Adults	7.2%
308	Tardive Dyskinesia	7.2%
309	Myotonic Dystrophy	7.1%
310	Kernicterus	7.1%
311	Dermatitis Herpetiformis	7.1%
312	AIDS Dementia Complex	7.1%
313	Voice Disorders	7%
314	Voice Disturbance	7%
315	Lateral Medullary Syndrome	6.9%
316	Neuritis	6.9%
317	Polyneuritis	6.9%
318	Radiculitis	6.9%
319	Polyneuropathy	6.9%
320	Mononeuritis	6.9%
321	Mononeuropathies	6.9%
322	Brachial Plexus Neuropathies	6.9%
323	Radiculopathy	6.9%
324	Mononeuropathy Multiplex	6.9%
325	Nerve Root Compression	6.9%
326	Choroid Plexus Papilloma	6.9%
327	Alcohol Withdrawal Seizures	6.9%
328	Smith-Magenis syndrome	6.9%
329	Dural Arteriovenous Fistula	6.8%
330	Brain Diseases, Metabolic, Inborn	6.8%
331	Empty Sella Syndrome	6.6%
332	Hyperpituitarism	6.6%
333	Hypopituitarism	6.6%
334	Hypophysitis	6.6%
335	Optic Nerve Glioma	6.5%
336	Akathisia	6.5%
337	Restlessness	6.5%
338	Psychomotor Agitation	6.5%
339	Cerebral Arterial Diseases	6.5%
340	Vertebrobasilar Insufficiency	6.5%
341	Basilar Artery Stenosis	6.5%
342	Vertebral Artery Stenosis	6.5%
343	Intracranial Hemorrhage, Hypertensive	6.5%
344	Transient Cerebral Ischemia	6.5%
345	Cluster Headache	6.3%
346	Migraine with Aura	6.3%
347	Familial Hemiplegic Migraine	6.3%
348	Chronic Paroxysmal Hemicrania	6.3%
349	SUNCT Syndrome	6.3%
350	Paroxysmal Hemicrania	6.3%
351	Rheumatoid Arthritis	6.3%
352	Juvenile arthritis	6.3%
353	Carpal Tunnel Syndrome	6.3%
354	neurofibroma	6.2%
355	Graves Disease	6.2%
356	Sciatica	6.2%
357	Anti-Glomerular Basement Membrane Disease	6.2%
358	Hypersensitivity	6.1%
359	Immunologic Deficiency Syndromes	6.1%
360	Immunoproliferative Disorders	6.1%
361	Immune reconstitution syndrome	6.1%
362	Immune Reconstitution Inflammatory Syndrome	6.1%
363	Reflex, Abnormal	6%
364	Hyporeflexia	6%
365	Hyperreflexia	6%
366	Alstrom Syndrome	6%
367	Wernicke Encephalopathy	6%
368	West Nile Fever	6%
369	Autoimmune thrombocytopenia	6%
370	Immune thrombocytopenic purpura	6%
371	Gait Apraxia	5.9%
372	Myositis	5.8%
373	Optic Atrophy	5.8%
374	Optic Neuritis	5.8%
375	Papilledema	5.8%
376	Strabismus	5.8%
377	Tolosa-Hunt Syndrome	5.8%
378	Isaacs syndrome	5.8%
379	Arsenic Poisoning	5.8%
380	Myotonic Disorders	5.8%
381	Myasthenic Syndromes, Congenital	5.8%
382	Diabetic Neuropathies	5.8%
383	Facial Injuries	5.8%
384	Facial Neuralgia	5.8%
385	Diabetic Amyotrophy	5.8%
386	Diabetic Autonomic Neuropathy	5.8%
387	Sleep Talking	5.8%
388	Manganese Poisoning	5.8%
389	Sleep Disorders, Intrinsic	5.8%
390	Orthostatic intolerance	5.8%
391	Anosmia	5.7%
392	Ataxia	5.7%
393	Athetosis	5.7%
394	Catalepsy	5.7%
395	Dystonia	5.7%
396	Hemiplegia	5.7%
397	Locked-In Syndrome	5.7%
398	Meningeal Neoplasms	5.7%
399	Meningomyelocele	5.7%
400	Muscle Hypertonia	5.7%
401	Muscle hypotonia	5.7%
402	Myoclonus	5.7%
403	Myotonia	5.7%
404	Neuralgia	5.7%
405	Paraplegia	5.7%
406	Pseudobulbar Palsy	5.7%
407	Quadriplegia	5.7%
408	Spasm	5.7%
409	Spastic Paraplegia	5.7%
410	Status Epilepticus	5.7%
411	Taste Disorders	5.7%
412	Tremor	5.7%
413	Spina Bifida	5.7%
414	Monoplegia	5.7%
415	Hypokinesia	5.7%
416	Paraparesis	5.7%
417	Bradykinesia	5.7%
418	Waxy flexibility	5.7%
419	Action Tremor	5.7%
420	Resting Tremor	5.7%
421	Dysosmia	5.7%
422	Quadriparesis	5.7%
423	Mercury Poisoning, Nervous System	5.7%
424	Olfaction Disorders	5.7%
425	Myokymia	5.7%
426	Lead Poisoning, Nervous System	5.7%
427	Vestibular Neuronitis	5.7%
428	Spinal Cord Ischemia	5.7%
429	Somatosensory Disorders	5.7%
430	Neuropathic pain	5.7%
431	Hyperkinesia	5.7%
432	Intention tremor	5.7%
433	Tuberculosis, Central Nervous System	5.7%
434	Carotid Stenosis	5.6%
435	Intracranial Aneurysm	5.6%
436	Hematoma, Subdural	5.6%
437	Hematoma, Epidural, Cranial	5.6%
438	Intracranial Arteriosclerosis	5.6%
439	Cerebral Atherosclerosis	5.6%
440	Subarachnoid Hemorrhage	5.6%
441	Cerebral Arteriosclerosis	5.6%
442	Cerebral Hemorrhage	5.6%
443	Cerebral Thrombosis	5.5%
444	Cubital Tunnel Syndrome	5.5%
445	Intracranial Embolism	5.5%
446	Intracranial Thrombosis	5.5%
447	Amyloid Neuropathies, Familial	5.3%
448	Hyperprolactinemia	5.3%
449	Acoustic Neuroma	5.3%
450	Subclavian Steal Syndrome	5.2%
451	Pick Disease of the Brain	5.2%
452	Leukoencephalopathy	5.2%
453	Transfusion Reaction	5.2%
454	Hypotensive Transfusion Reaction	5.2%
455	Hand-Arm Vibration Syndrome	5.1%
456	Vision Disorders	5.1%
457	Metamorphopsia	5.1%
458	Visual Impairment	5.1%
459	Fibromyalgia	5%
460	Optic Neuropathy, Ischemic	5%
461	Anterior Ischemic Optic Neuropathy	5%
462	Medial Tibial Stress Syndrome	5%
463	Facial Hemiatrophy	5%
464	Melkersson-Rosenthal Syndrome	5%
465	Mitochondrial Myopathies	5%
466	Anisocoria	5%
467	Confusion	5%
468	Facial paralysis	5%
469	Lethargy	5%
470	Memory Disorders	5%
471	Muscle Cramp	5%
472	Perceptual Disorders	5%
473	Psychomotor Disorders	5%
474	Tonic Pupil	5%
475	Eosinophilia-Myalgia Syndrome	5%
476	Anhedonia	5%
477	Disorientation	5%
478	Facial Paresis	5%
479	Memory Loss	5%
480	Hemisensory Neglect	5%
481	Dysacusis	5%
482	Sleep Bruxism	4.9%
483	Anencephaly	4.9%
484	Meningocele	4.9%
485	Muscular Atrophy	4.9%
486	Respiratory Paralysis	4.9%
487	Neuroaspergillosis	4.9%
488	Encephalocele	4.9%
489	Tetany	4.9%
490	Sciatic Neuropathy	4.9%
491	Ulnar Neuropathies	4.9%
492	Lesion of Sciatic Nerve	4.9%
493	Ulnar Neuritis	4.9%
494	Radial nerve compression	4.9%
495	Radial Tunnel Syndrome	4.9%
496	Peroneal Neuropathies	4.9%
497	Radial Neuropathy	4.9%
498	Median Neuropathy	4.9%
499	Sciatic Nerve Palsy	4.9%
500	Femoral Neuropathy	4.9%
501	Tibial Neuropathy	4.9%
502	Ulnar Nerve Palsy	4.9%
503	Postural Orthostatic Tachycardia Syndrome	4.9%
504	Radial nerve palsy	4.9%
505	Carotid Artery Thrombosis	4.8%
506	Classical Lissencephalies and Subcortical Band Heterotopias	4.8%
507	Hematoma, Subdural, Intracranial	4.7%
508	Hematoma, Subdural, Chronic	4.7%
509	Hematoma, Subdural, Acute	4.7%
510	Acromegaly	4.6%
511	Cerebral Amyloid Angiopathy	4.5%
512	Sinus Thrombosis, Intracranial	4.5%
513	Pseudorabies	4.5%
514	Duane Retraction Syndrome	4.4%
515	Consciousness Disorders	4.4%
516	Mental Retardation	4.4%
517	Muscle Weakness	4.4%
518	Depressed Level of Consciousness	4.4%
519	Mental deficiency	4.4%
520	Intellectual Disability	4.4%
521	Mobius Syndrome	4.4%
522	Bell Palsy	4.4%
523	Catatonia	4.3%
524	Herpes Zoster Oticus	4.3%
525	Familial Periodic Paralysis	4.3%
526	Anterior Spinal Artery Syndrome	4.3%
527	Aphonia	4.3%
528	Sleep Deprivation	4.3%
529	Dysphonia	4.3%
530	Alexia	4.3%
531	Dyslexia	4.3%
532	POEMS Syndrome	4.3%
533	Glomerulonephritis, Membranoproliferative	4.3%
534	Neurosyphilis	4.3%
535	Granulomatosis with polyangiitis	4.2%
536	Menkes Kinky Hair Syndrome	4.2%
537	Kearns-Sayre syndrome	4.1%
538	Thoracic Outlet Syndrome	4.1%
539	Fabry Disease	4.1%
540	Esotropia	4.1%
541	Exotropia	4.1%
542	Hypotension, Orthostatic	4.1%
543	Sleep Apnea Syndromes	4.1%
544	Polymyositis	4.1%
545	Post-Exercise Hypotension	4.1%
546	Disorders of Excessive Somnolence	4.1%
547	Sleep Initiation and Maintenance Disorders	4.1%
548	Night Terrors	4.1%
549	Somnambulism	4.1%
550	Trigeminal Nerve Disorder	4.1%
551	Transient Insomnia	4.1%
552	Sleep Paralysis	4.1%
553	Chronic Insomnia	4.1%
554	REM Sleep Behavior Disorder	4.1%
555	Hypersomnia	4.1%
556	Dermal Sinus	4.1%
557	Dysgeusia	4.1%
558	Formication	4.1%
559	Hyperalgesia	4.1%
560	Hyperesthesia	4.1%
561	Hypesthesia	4.1%
562	Language Disorders	4.1%
563	Numbness	4.1%
564	Paresthesia	4.1%
565	Paraparesis, Spastic	4.1%
566	Spina Bifida Cystica	4.1%
567	Trismus	4.1%
568	Spina Bifida Occulta	4.1%
569	Epilepsia Partialis Continua	4.1%
570	Hypogeusia	4.1%
571	Meningeal Carcinomatosis	4.1%
572	Brown-Sequard Syndrome	4.1%
573	Lissencephaly	4.1%
574	Polymicrogyria	4.1%
575	Pachygyria	4.1%
576	Schizencephaly	4.1%
577	Lockjaw	4.1%
578	Allodynia	4.1%
579	Lead Poisoning, Nervous System, Childhood	4.1%
580	Lead Poisoning, Nervous System, Adult	4.1%
581	Periventricular Nodular Heterotopia	4.1%
582	Ageusia	4.1%
583	Neurofibrosarcoma	4%
584	Optic Atrophy, Hereditary, Leber	4%
585	Cavernous Sinus Thrombosis	4%
586	Sagittal Sinus Thrombosis	4%
587	Polyradiculopathy	3.9%
588	Galactosemias	3.9%
589	Urea Cycle Disorders, Inborn	3.9%
590	Tyrosinemias	3.9%
591	Myalgia	3.8%
592	Neuronal Ceroid-Lipofuscinoses	3.8%
593	Lyme Neuroborreliosis	3.8%
594	Toxoplasmosis, Congenital	3.8%
595	Malaria, Cerebral	3.7%
596	Neurocysticercosis	3.7%
597	Felty Syndrome	3.7%
598	Waterhouse-Friderichsen Syndrome	3.7%
599	Lupus Nephritis	3.7%
600	Eye Injuries	3.6%
601	Homocystinuria	3.6%
602	Muscular Dystrophy	3.5%
603	Congenital nystagmus	3.5%
604	Orbital Myositis	3.5%
605	Leigh Disease	3.5%
606	Prolactinoma	3.5%
607	Growth Hormone-Secreting Pituitary Adenoma	3.5%
608	Diplopia	3.5%
609	Muscle Rigidity	3.5%
610	Muscle Spasticity	3.5%
611	Scotoma	3.5%
612	Photophobia	3.5%
613	Cogwheel Rigidity	3.5%
614	Hemifacial Spasm	3.5%
615	Amaurosis	3.5%
616	Blindness	3.5%
617	Nuchal Rigidity	3.5%
618	Pyomyositis	3.5%
619	Aicardi's syndrome	3.5%
620	Agnosia	3.5%
621	Apraxias	3.5%
622	Hallucinations	3.5%
623	Hemianopsia	3.5%
624	Hyperacusis	3.5%
625	Tinnitus	3.5%
626	Visual Agnosia	3.5%
627	Anosognosia	3.5%
628	Wernicke-Korsakoff Syndrome	3.5%
629	Phonophobia	3.5%
630	Hearing Loss	3.5%
631	Hoarseness	3.5%
632	Nelson Syndrome	3.5%
633	Sarcopenia	3.5%
634	Cockayne Syndrome	3.5%
635	Alcohol Withdrawal Delirium	3.4%
636	Immune Complex Diseases	3.3%
637	Latex allergy	3.3%
638	Thrombocytopenic purpura	3.3%
639	Rheumatoid Vasculitis	3.3%
640	Sleep Apnea, Obstructive	3.2%
641	Sleep Apnea, Central	3.2%
642	Narcolepsy	3.2%
643	Trigeminal Neuralgia	3.2%
644	Kleine-Levin Syndrome	3.2%
645	Agraphia	3.2%
646	Anomia	3.2%
647	Cluttering	3.2%
648	Language Development Disorders	3.2%
649	Speech Disorders	3.2%
650	Syncope	3.2%
651	Stupor	3.2%
652	Dysgraphia	3.2%
653	Presyncope	3.2%
654	Dyslalia	3.2%
655	Holoprosencephaly	3.1%
656	Amnesia	3.1%
657	Delirium	3.1%
658	Dissociative Amnesia	3.1%
659	Color blindness	3.1%
660	Global Amnesia	3.1%
661	Cri-du-Chat Syndrome	3.1%
662	Down Syndrome	3.1%
663	Trisomy 21	3.1%
664	Meningioma	3.1%
665	Williams Syndrome	3.1%
666	Microcephaly	3%
667	Macrocephaly	3%
668	Hypokalemic periodic paralysis	3%
669	Porencephaly	3%
670	Sicca Syndrome	2.9%
671	Sjogren's Syndrome	2.9%
672	Environmental Illness	2.9%
673	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.9%
674	Cataplexy	2.8%
675	Aphasia	2.8%
676	Articulation Disorders	2.8%
677	Echolalia	2.8%
678	Stuttering	2.8%
679	Dysphasia	2.8%
680	Eye Burns	2.8%
681	Zellweger Syndrome	2.8%
682	Lymphoproliferative Disorders	2.8%
683	Welander Distal Myopathy	2.8%
684	Amaurosis Fugax	2.8%
685	Blindness, Cortical	2.8%
686	Dyscalculia	2.8%
687	Rett Syndrome	2.8%
688	Paraproteinemias	2.8%
689	Deafness	2.8%
690	Hearing Loss, Sudden	2.8%
691	Gerstmann Syndrome	2.8%
692	Hearing Loss, Bilateral	2.8%
693	Hearing Loss, High-Frequency	2.8%
694	Hearing Loss, Mixed Conductive-Sensorineural	2.8%
695	Prosopagnosia	2.8%
696	Apraxia, Ideomotor	2.8%
697	Charles Bonnet Syndrome	2.8%
698	Hearing Loss, Unilateral	2.8%
699	Complete Hearing Loss	2.8%
700	Alien Hand Syndrome	2.8%
701	Deaf Mutism	2.8%
702	Lymphopenia	2.8%
703	Prader-Willi Syndrome	2.7%
704	Phantom pain	2.7%
705	Phantom Limb Pain	2.7%
706	Dysarthria	2.6%
707	Glycogen storage disease type II	2.6%
708	Dermatomyositis	2.5%
709	Corneal Scar	2.5%
710	Primary amyloidosis	2.5%
711	Monoclonal Gammopathy of Undetermined Significance	2.5%
712	Mutism	2.5%
713	Selective Mutism	2.5%
714	Muscular Dystrophy, Duchenne	2.4%
715	Retrograde amnesia	2.4%
716	Amnesia, Anterograde	2.4%
717	Hypergammaglobulinemia	2.4%
718	Agammaglobulinemia	2.4%
719	Kounis Syndrome	2.4%
720	HIV Infections	2.4%
721	Transfusion-Related Acute Lung Injury	2.4%
722	Alexia, Pure	2.3%
723	Rubinstein-Taybi Syndrome	2.2%
724	Asthma, Aspirin-Induced	2.2%
725	Fragile X Syndrome	2.2%
726	Corneal Perforation	2.1%
727	Gaucher Disease	2.1%
728	Serum Sickness	2%
729	Multiple Myeloma	2%
730	anaphylaxis	2%
731	Food Allergy	2%
732	Anaphylactic shock	2%
733	Tay-Sachs Disease	1.9%
734	Niemann-Pick Disease, Type C	1.8%
735	Respiratory Hypersensitivity	1.7%
736	Sick Building Syndrome	1.7%
737	Multiple Chemical Sensitivity	1.7%
738	Plasmacytoma	1.6%
739	Tumor Lysis Syndrome	1.6%
740	Urticaria	1.6%
741	Vasculitis, Leukocytoclastic, Cutaneous	1.6%
742	HTLV-I Infections	1.6%
743	Job Syndrome	1.6%
744	Mucopolysaccharidosis II	1.6%
745	Hydrops Fetalis	1.5%
746	Sezary Syndrome	1.5%
747	Lymphoma	1.4%
748	Mastocytosis	1.4%
749	Drug Eruptions	1.4%
750	Chronic granulomatous disease	1.4%
751	Heavy Chain Disease	1.4%
752	Dermatitis, Allergic Contact	1.4%
753	HIV Seropositivity	1.4%
754	Milk Allergy	1.3%
755	Schnitzler Syndrome	1.3%
756	Wheat Hypersensitivity	1.3%
757	Acquired Immunodeficiency Syndrome	1.2%
758	AIDS related complex	1.2%
759	Infectious Mononucleosis	1.2%
760	Cryoglobulinemia	1.2%
761	AIDS-Related Opportunistic Infections	1.1%
762	Dermatitis, Atopic	1.1%
763	HIV Wasting Syndrome	1.1%
764	AIDS-Associated Nephropathy	1.1%
765	Mastocytosis, Systemic	1.1%
766	Waldenstrom Macroglobulinemia	1%
767	Wiskott-Aldrich Syndrome	1%
768	HIV-Associated Lipodystrophy Syndrome	1%
769	Angioedema	0.9%
770	Hodgkin Disease	0.9%
771	Leukemia, Plasma Cell	0.9%
772	Lymphoma, Non-Hodgkin	0.9%
773	Leukemia, T-Cell	0.9%
774	Acute Generalized Exanthematous Pustulosis	0.9%
775	Leukemia, B-Cell	0.9%
776	Asthma	0.8%
777	Composite Lymphoma	0.8%
778	Erythema Nodosum	0.8%
779	Dermatitis, Photoallergic	0.8%
780	Lymphangioleiomyomatosis	0.8%
781	Aspergillosis, Allergic Bronchopulmonary	0.7%
782	Asthma, Exercise-Induced	0.7%
783	Status Asthmaticus	0.7%
784	Lymphoma, Follicular	0.7%
785	T-Cell Lymphoma	0.7%
786	Mantle cell lymphoma	0.7%
787	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.7%
788	Leukemia, Large Granular Lymphocytic	0.7%
789	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.7%
790	Toxic Epidermal Necrolysis	0.7%
791	Stevens-Johnson Syndrome	0.7%
792	Asthma, Occupational	0.6%
793	Farmer's Lung	0.6%
794	Angioedemas, Hereditary	0.6%
795	Hay fever	0.6%
796	Rhinitis, Allergic, Perennial	0.6%
797	Hereditary Angioedema Type III	0.6%
798	Hereditary Angioedema Types I and II	0.6%
799	Lymphoma, T-Cell, Cutaneous	0.6%
800	Lymphoma, AIDS-Related	0.6%
801	Enteropathy-Associated T-Cell Lymphoma	0.6%
802	Primary Effusion Lymphoma	0.6%
803	Mycosis Fungoides	0.5%
804	Lymphomatoid Papulosis	0.5%
805	Plasmablastic lymphoma	0.5%
806	Lymphomatoid Granulomatosis	0.5%
807	Burkitt Lymphoma	0.4%

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