MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteomalacia

(UMLS:C0029442)

UMLS ID:: C0029442
MeSH ID:: D010018

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.198.816.640

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.104.816.640|C18.452.174.845.640|C18.654.521.500.133.770.734.640

Synonym(s)

Osteomalacia

OM - Osteomalacia

OSTEOMALACIA

Osteomalacia, unspecified

Softening of the bones

malacia; bone

osteomalacia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	adefovir dipivoxil	FAERS: 233	18815461	CTD US FAERS
2	Alendronate	FAERS: 27		US FAERS
3	Tenofovir	FAERS: 19 Canada Vigilance: 2		Canada Vigilance US FAERS
4	Tenofovir	FAERS: 14 Canada Vigilance: 1	19265350	CTD SIDER Canada Vigilance US FAERS
5	Carbamazepine	FAERS: 13	17016548	CTD SIDER US FAERS
6	Ifosfamide	FAERS: 8	7663031 11219485 15975640	CTD SIDER US FAERS
7	Zoledronic Acid	FAERS: 7 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Lenalidomide	FAERS: 4		US FAERS
9	Alendronate	FAERS: 3		US FAERS
10	Dimethyl Fumarate	FAERS: 3		US FAERS
11	Phenytoin	FAERS: 3 Canada Vigilance: 2	View details 188784 4148461 6705322 17016548	CTD SIDER Canada Vigilance US FAERS
12	Didanosine	FAERS: 2		US FAERS
13	Emtricitabine, Rilpivirine, Tenofovir Drug Combination	FAERS: 2		US FAERS
14	Gabapentin	FAERS: 2		US FAERS
15	Medroxyprogesterone Acetate	FAERS: 2		US FAERS
16	Teriparatide	FAERS: 2		US FAERS
17	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
18	Anastrozole	FAERS: 1		US FAERS
19	Axitinib	FAERS: 1		US FAERS
20	CID 129626832	FAERS: 1		US FAERS
21	Cinacalcet	FAERS: 1		US FAERS
22	Duloxetine Hydrochloride	FAERS: 1		US FAERS
23	Enalapril	FAERS: 1		US FAERS
24	Etidronic Acid	FAERS: 1		SIDER US FAERS
25	Furosemide	FAERS: 1		US FAERS
26	Glatiramer Acetate	FAERS: 1		US FAERS
27	Lamotrigine	FAERS: 1		US FAERS
28	Levodopa	FAERS: 1		US FAERS
29	Medroxyprogesterone	FAERS: 1		US FAERS
30	Methotrexate	FAERS: 1		US FAERS
31	Pamidronate	FAERS: 1		US FAERS
32	Phenytoin	FAERS: 1		US FAERS
33	Pioglitazone	FAERS: 1		US FAERS
34	Pramipexole	FAERS: 1		US FAERS
35	Raloxifene Hydrochloride	FAERS: 1		US FAERS
36	Risedronic Acid	FAERS: 1		US FAERS
37	Rosuvastatin Calcium	FAERS: 1		US FAERS
38	Spironolactone	FAERS: 1		US FAERS
39	Tenofovir	FAERS: 1		US FAERS
40	Topiramate	FAERS: 1		SIDER US FAERS
41	Valproic Acid	FAERS: 1		US FAERS
42	carfilzomib	FAERS: 1		US FAERS
43	ferrous gluconate	FAERS: 1		US FAERS
44	ziprasidone	FAERS: 1		US FAERS
45	25-hydroxyvitamin D		6705322	CTD
46	Acetazolamide			SIDER
47	Aluminum Hydroxide		6858403	CTD
48	Aluminum		4050784	CTD
49	Cadmium Compounds		21697648	CTD
50	Calcitriol		1517380 15975640	CTD
51	Emtricitabine			SIDER
52	Ergocalciferols		4148461	CTD
53	Fluconazole	Canada Vigilance: 1		Canada Vigilance
54	Folic Acid		4148461	CTD
55	Phenobarbital		188784 4148461 17016548	CTD SIDER
56	Phosphates		1013714 1517380	CTD SIDER
57	Strontium		16815919	CTD
58	Vitamin D		1013714	CTD
59	Voriconazole			SIDER
60	adefovir			SIDER
61	efavirenz			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Renal Osteodystrophy	40.5%
2	Renal rickets	40.5%
3	Pseudohypoparathyroidism	35.5%
4	Wasting Syndrome	31.2%
5	Osteoporosis	28.7%
6	Bone Demineralization, Pathologic	28.7%
7	Post-Traumatic Osteoporosis	28.7%
8	Hypercalcemia	28.3%
9	Hypocalcemia	28.3%
10	Milk-Alkali Syndrome	28.3%
11	Familial Hypophosphatemic Rickets	28.2%
12	Acid-Base Imbalance	22.3%
13	Iron Metabolism Disorders	22.3%
14	Phosphorus Metabolism Disorders	22.3%
15	Water-Electrolyte Imbalance	22.3%
16	Lipid Metabolism Disorders	22.3%
17	Mitochondrial Diseases	22.3%
18	Glucose Metabolism Disorders	22.3%
19	Calcinosis	20.7%
20	Hyperhomocysteinemia	19.1%
21	Osteoporosis, Postmenopausal	18.8%
22	Lipodystrophy	18.7%
23	Brain Diseases, Metabolic	18.7%
24	Brain Diseases, Metabolic, Inborn	16.4%
25	Leigh Disease	16.4%
26	Child Nutrition Disorders	14.6%
27	Hypervitaminosis A	14.6%
28	Infant Nutrition Disorders	14.6%
29	Ascorbic Acid Deficiency	14.3%
30	Vitamin A Deficiency	14.3%
31	Vitamin E Deficiency	14.3%
32	Carbamoyl-Phosphate Synthase I Deficiency Disease	14.2%
33	Calciphylaxis	13.6%
34	Vascular calcification	13.6%
35	Starvation	13.5%
36	Refeeding Syndrome	13.5%
37	Lactose Intolerance	13.4%
38	Magnesium Deficiency	13.4%
39	Potassium Deficiency	13.4%
40	Protein Deficiency	13.4%
41	Mitochondrial Encephalomyopathies	13%
42	Acidosis	13%
43	Alkalosis	13%
44	Amyloidosis	13%
45	Hyperglycemia	13%
46	Hyperinsulinism	13%
47	Hyperkalemia	13%
48	Hypernatremia	13%
49	Hypoglycemia	13%
50	Hypokalemia	13%
51	Hyponatremia	13%
52	Xanthomatosis	13%
53	Hypophosphatemia	13%
54	Metabolic acidosis	13%
55	Dyslipidemias	13%
56	Iron Overload	13%
57	Xanthoma	13%
58	Smith-Lemli-Opitz Syndrome	12.7%
59	Galactosemias	12.6%
60	Urea Cycle Disorders, Inborn	12.6%
61	Tyrosinemias	12.6%
62	Calcium Metabolism Disorders	12.5%
63	Nutrition Disorders	12.1%
64	Hypolipoproteinemias	12%
65	Mitochondrial Myopathies	11.8%
66	HIV Wasting Syndrome	11.7%
67	Hyperlipoproteinemia Type IV	11.5%
68	Hyperlipoproteinemia Type V	11.5%
69	Hyperphosphaturia	11.5%
70	Diabetes Mellitus	11.3%
71	Osteoarthropathy, Secondary Hypertrophic	11.1%
72	Dehydration	11%
73	Lipomatosis	11%
74	Water Intoxication	11%
75	Werner Syndrome	11%
76	Achlorhydria	10.9%
77	Amino Acid Metabolism, Inborn Errors	10.9%
78	Bloom Syndrome	10.9%
79	Carbohydrate Metabolism, Inborn Errors	10.9%
80	Metal Metabolism, Inborn Errors	10.9%
81	Progeria	10.9%
82	Lysosomal Storage Diseases	10.9%
83	Cytochrome-c Oxidase Deficiency	10.9%
84	Peroxisomal Disorders	10.9%
85	Wernicke Encephalopathy	10.8%
86	Celiac Disease	10.8%
87	Sprue, Tropical	10.8%
88	Steatorrhea	10.8%
89	Sprue	10.8%
90	Congenital Hyperinsulinism	10.8%
91	Osteopenia	10.6%
92	Homocystinuria	10.5%
93	Diabetic Ketoacidosis	10.5%
94	Hyperlipidemia, Familial Combined	10.4%
95	Vitamin K Deficiency	10.3%
96	Glycogen storage disease type II	10.2%
97	Rickets	10%
98	Gaucher Disease	10%
99	Bone Diseases, Developmental	9.8%
100	Hyperostosis	9.8%
101	Osteitis	9.8%
102	Osteitis Deformans	9.8%
103	Osteochondrosis	9.8%
104	Spinal Diseases	9.8%
105	Nephrocalcinosis	9.7%
106	Tetany	9.7%
107	Hyperlipoproteinemia Type III	9.6%
108	Amyloid Neuropathies, Familial	9.5%
109	Osteochondritis	9.5%
110	Adrenoleukodystrophy	9.4%
111	Myelinolysis, Central Pontine	9.4%
112	Renal tubular acidosis	9.4%
113	MELAS Syndrome	9.3%
114	Glycosuria	9.3%
115	Reye Syndrome	9.3%
116	Hepatic Encephalopathy	9.3%
117	Zellweger Syndrome	9.1%
118	Menkes Kinky Hair Syndrome	9.1%
119	Folic Acid Deficiency	9%
120	Pellagra	9%
121	Thiamine Deficiency	9%
122	Vitamin B 12 Deficiency	9%
123	Vitamin B 6 Deficiency	9%
124	Pyridoxine Deficiency	9%
125	Gout	8.8%
126	Hypoalphalipoproteinemias	8.8%
127	Hepatolenticular Degeneration	8.6%
128	Cockayne Syndrome	8.5%
129	Platybasia	8.5%
130	Bone Diseases, Endocrine	8.5%
131	HIV-Associated Lipodystrophy Syndrome	8.5%
132	Refsum Disease	8.5%
133	Acidosis, Lactic	8.4%
134	Hemosiderosis	8.4%
135	Ketosis	8.4%
136	Ketonuria	8.4%
137	Ketoacidosis	8.4%
138	Ketonemia	8.4%
139	Gigantism	8.4%
140	Spinal Neoplasms	8.4%
141	Spondylitis	8.4%
142	Bone Diseases, Infectious	8.3%
143	Bone neoplasms	8.3%
144	Porphyrias, Hepatic	8.3%
145	Bone Resorption	8.2%
146	Aseptic Necrosis of Bone	8.2%
147	Necrobiosis Lipoidica Diabeticorum	8.2%
148	Fabry Disease	8.2%
149	Neuronal Ceroid-Lipofuscinoses	8.2%
150	Fanconi Anemia	8.1%
151	Niemann-Pick Disease, Type C	8.1%
152	Tay-Sachs Disease	8.1%
153	Marasmus	7.9%
154	Nesidioblastosis	7.8%
155	Glycosuria, Renal	7.7%
156	Kwashiorkor	7.6%
157	Familial Periodic Paralysis	7.4%
158	Antley-Bixler Syndrome Phenotype	7.4%
159	Kearns-Sayre syndrome	7.3%
160	Friedreich Ataxia	7.2%
161	Acidosis, Respiratory	7.1%
162	Adiposis Dolorosa	7.1%
163	Alkalosis, Respiratory	7.1%
164	Alkaptonuria	7%
165	Glycogen Storage Disease	7%
166	Hypophosphatasia	7%
167	Insulin Resistance	7%
168	Propionic acidemia	7%
169	Dihydropyrimidine Dehydrogenase Deficiency	7%
170	Cystinosis	7%
171	Pectus carinatum	7%
172	Mucopolysaccharidosis III	6.8%
173	CREST Syndrome	6.8%
174	Kernicterus	6.6%
175	Osteomalacia	6.6%
176	Pectus excavatum	6.6%
177	Malnutrition	6.5%
178	Scurvy	6.5%
179	Beriberi	6.4%
180	Arthrogryposis	6.3%
181	Gestational Diabetes	6.2%
182	Latent Autoimmune Diabetes in Adults	6.2%
183	Hypercholesterolemia	6.2%
184	Hyperlipoproteinemias	6.2%
185	Hypertriglyceridemia	6.2%
186	Diabetes Mellitus, Experimental	6.1%
187	Ataxia Telangiectasia	6.1%
188	Fasciitis	6%
189	Foot Deformities	6%
190	Arthropathy	6%
191	Cerebral Amyloid Angiopathy	6%
192	Arthritis, Gouty	5.9%
193	Optic Atrophy, Hereditary, Leber	5.9%
194	Ainhum	5.8%
195	Dysostoses	5.8%
196	Spinal Stenosis	5.8%
197	Spondylosis	5.8%
198	Intervertebral Disc Degeneration	5.8%
199	Sjogren-Larsson Syndrome	5.7%
200	Xeroderma Pigmentosum	5.5%
201	Contracture	5.5%
202	Fasciitis, Plantar	5.5%
203	Discitis	5.5%
204	Congenital Hypothyroidism	5.5%
205	Metabolic Diseases	5.5%
206	Eosinophilic Granuloma	5.4%
207	Primary amyloidosis	5.3%
208	Anemia, Pernicious	5.3%
209	Variegate Porphyria	5.3%
210	Acute intermittent porphyria	5.3%
211	Porphyria Cutanea Tarda	5.3%
212	Renal Aminoacidurias	5.3%
213	Fanconi Syndrome	5.3%
214	Pseudohypoaldosteronism	5.3%
215	Liddle Syndrome	5.3%
216	Jaw Diseases	5.2%
217	Canavan Disease	5.2%
218	Alexander Disease	5.2%
219	Klippel-Feil Syndrome	5.1%
220	Synostosis	5.1%
221	Mucopolysaccharidosis II	5.1%
222	Glycogen Storage Disease Type I	5.1%
223	Glycogen Storage Disease Type V	5.1%
224	Cartilage Diseases	5.1%
225	Foot Diseases	5.1%
226	Myopathy	5.1%
227	Rheumatism	5.1%
228	Chondromalacia	5.1%
229	Hypokalemic periodic paralysis	5.1%
230	Obesity	5%
231	Multiple Epiphyseal Dysplasia	4.9%
232	Osteochondrodysplasias	4.9%
233	Osteomyelitis	4.9%
234	Periostitis	4.9%
235	Alveolar Bone Loss	4.8%
236	Femur Head Necrosis	4.8%
237	Osteolysis	4.8%
238	Tuberculosis, Spinal	4.8%
239	Amyotrophic Lateral Sclerosis	4.8%
240	Fibromyalgia	4.7%
241	Polymyalgia Rheumatica	4.7%
242	Metatarsalgia	4.7%
243	Osteoarthritis, Spine	4.6%
244	Dwarfism	4.4%
245	Acromegaly	4.2%
246	Joint Tuberculosis	4.2%
247	Tuberculosis, Osteoarticular	4.2%
248	Bone Tuberculosis	4.2%
249	Craniofacial Dysostosis	4.1%
250	Albinism	3.9%
251	Deficiency Diseases	3.9%
252	Frontotemporal dementia	3.9%
253	Chondrodysplasia Punctata	3.8%
254	Enchondromatosis	3.8%
255	Lordosis	3.8%
256	Osteosclerosis	3.8%
257	Spondylolysis	3.8%
258	kyphosis	3.8%
259	Kashin-Beck Disease	3.8%
260	Cystinuria	3.8%
261	Ankylosing spondylitis	3.8%
262	Craniosynostosis	3.8%
263	Syndactyly	3.8%
264	Brachycephaly	3.8%
265	Rheumatic Fever	3.7%
266	Temporomandibular Joint Disorders	3.7%
267	Ischemic contracture	3.7%
268	Subacute Combined Degeneration	3.7%
269	Acrocephalosyndactylia	3.5%
270	Spondylarthropathies	3.5%
271	Obesity, Abdominal	3.4%
272	Rheumatoid Arthritis	3.3%
273	Juvenile arthritis	3.3%
274	Arthritis, Psoriatic	3.3%
275	Ichthyosis, X-Linked	3.3%
276	Arthritis	3.3%
277	Bursitis	3.3%
278	Joint Instability	3.3%
279	Myofascial Pain Syndromes	3.3%
280	Rhabdomyolysis	3.3%
281	Synovitis	3.3%
282	Joint laxity	3.3%
283	Polyarthritis	3.3%
284	Frozen shoulder	3.3%
285	Patellofemoral Pain Syndrome	3.3%
286	Hip Contracture	3.2%
287	Periarthritis	3.2%
288	Temporomandibular Joint Dysfunction Syndrome	3.1%
289	Talipes	3%
290	Pediatric Obesity	2.9%
291	Arthritis, Reactive	2.9%
292	Melorheostosis	2.9%
293	Osteopetrosis	2.9%
294	Spondylolisthesis	2.9%
295	Osteogenesis Imperfecta	2.8%
296	Compartment syndromes	2.8%
297	Maxillary Diseases	2.8%
298	Tendinitis	2.8%
299	Tendinopathy	2.8%
300	Basal Cell Nevus Syndrome	2.8%
301	Mastoiditis	2.8%
302	Petrositis	2.8%
303	Poland Syndrome	2.8%
304	Hemarthrosis	2.7%
305	Myositis	2.7%
306	Tietze's Syndrome	2.7%
307	Limb Deformities, Congenital	2.7%
308	Isaacs syndrome	2.7%
309	Craniofacial Abnormalities	2.7%
310	Myotonic Disorders	2.7%
311	Marfan Syndrome	2.7%
312	Osteoarthritis, Knee	2.7%
313	Rubinstein-Taybi Syndrome	2.7%
314	Prader-Willi Syndrome	2.7%
315	Mandibulofacial Dysostosis	2.6%
316	Avitaminosis	2.6%
317	Palatal Neoplasms	2.4%
318	Goldenhar Syndrome	2.4%
319	Medial Tibial Stress Syndrome	2.4%
320	Muscle Cramp	2.3%
321	Eosinophilia-Myalgia Syndrome	2.3%
322	Gastroschisis	2.3%
323	Muscle Rigidity	2.3%
324	Muscle Spasticity	2.3%
325	Cogwheel Rigidity	2.3%
326	Nuchal Rigidity	2.3%
327	Rheumatoid Nodule	2.3%
328	Jaw Abnormalities	2.3%
329	Chronic Fatigue Syndrome	2.1%
330	Congenital clubfoot	2.1%
331	Vertical Talus	2.1%
332	Nail-Patella Syndrome	2.1%
333	Giant Cell Epulis	2.1%
334	Muscle Weakness	2.1%
335	Musculoskeletal Pain	2.1%
336	Arthralgia	2%
337	Polyarthralgia	2%
338	Felty Syndrome	2%
339	Prognathism	2%
340	Bunion	1.9%
341	Fibrodysplasia Ossificans Progressiva	1.9%
342	Myoglobinuria	1.9%
343	Myositis Ossificans	1.9%
344	Tenosynovitis	1.9%
345	Sacroiliitis	1.9%
346	Vitamin D Deficiency	1.9%
347	Laryngomalacia	1.9%
348	Nose Neoplasms	1.8%
349	Myalgia	1.8%
350	Rheumatoid Vasculitis	1.8%
351	Arthritis, Infectious	1.6%
352	Sicca Syndrome	1.6%
353	Sjogren's Syndrome	1.6%
354	Anterior Compartment Syndrome	1.6%
355	Enthesopathy	1.6%
356	Arthritis, Experimental	1.6%
357	Abdominal Compartment Syndrome	1.6%
358	Amelia	1.6%
359	Arachnodactyly	1.6%
360	Ectromelia	1.6%
361	Hemimelia	1.6%
362	Phocomelia	1.6%
363	Sirenomelia	1.6%
364	Polymyositis	1.6%
365	Polydactyly	1.6%
366	Brachydactyly	1.6%
367	Plagiocephaly	1.6%
368	Lower Extremity Deformities, Congenital	1.6%
369	Upper Extremity Deformities, Congenital	1.6%
370	Myotonic Dystrophy	1.5%
371	Micrognathism	1.4%
372	Pierre Robin Syndrome	1.4%
373	Hip Dislocation	1.4%
374	Shoulder Dislocation	1.4%
375	Hip Dysplasia	1.4%
376	Muscular Dystrophy	1.4%
377	Orbital Myositis	1.4%
378	Dupuytren Contracture	1.4%
379	Pyomyositis	1.4%
380	Retrognathia	1.3%
381	Maxillofacial Abnormalities	1.2%
382	Myotonia Congenita	1.2%
383	Bronchomalacia	1.2%
384	Tracheomalacia	1.2%
385	Microcephaly	1.2%
386	Macrocephaly	1.2%
387	Shoulder Pain	1.2%
388	Cleft Palate	1.1%
389	Noonan Syndrome	1%
390	Welander Distal Myopathy	0.9%
391	Holoprosencephaly	0.9%
392	Dermatomyositis	0.8%
393	Muscular Dystrophy, Duchenne	0.8%
394	Porencephaly	0.8%
395	Radicular Cyst	0.5%

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