MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Limbic Encephalitis

(UMLS:C0338430)

Definition:: A paraneoplastic syndrome marked by degeneration of neurons in the LIMBIC SYSTEM. Clinical features include HALLUCINATIONS, loss of EPISODIC MEMORY; ANOSMIA; AGEUSIA; TEMPORAL LOBE EPILEPSY; DEMENTIA; and affective disturbance (depression). Circulating anti-neuronal antibodies (e.g., anti-Hu; anti-Yo; anti-Ri; and anti-Ma2) and small cell lung carcinomas or testicular carcinoma are frequently associated with this syndrome.
UMLS ID:: C0338430
MeSH ID:: D020363

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.614.550.450|C04.730.856.437

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.430.525|C10.228.228.245.700|C10.574.781.550

Synonym(s)

Limbic Encephalitis

Limbic encephalitis

Limbic encephalopathy

Paraneoplastic limbic encephalitis

encephalitis limbic

encephalopathy; paraneoplastic limbic

limbic encephalitis

limbic encephalopathy

paraneoplastic limbic; encephalopathy

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Carbamazepine	FAERS: 3	US FAERS
2	Azacitidine	FAERS: 1	US FAERS
3	Carboplatin	FAERS: 1	US FAERS
4	Dimethyl Fumarate	FAERS: 1	US FAERS
5	Lacosamide	FAERS: 1	US FAERS
6	Levetiracetam	FAERS: 1	US FAERS
7	Lorazepam	FAERS: 1	US FAERS
8	MDV 3100	FAERS: 1	US FAERS
9	eltrombopag	FAERS: 1	US FAERS
10	eribulin	FAERS: 1	US FAERS
11	montelukast	FAERS: 1	US FAERS
12	osimertinib	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Meningoencephalitis	48.7%
2	Paraneoplastic Cerebellar Degeneration	44%
3	Myelitis, Transverse	39.3%
4	Opsoclonus-Myoclonus Syndrome	37.7%
5	Lambert-Eaton Myasthenic Syndrome	37.3%
6	Cerebral Ventriculitis	36.3%
7	Encephalomyelitis	33.2%
8	Multiple System Atrophy	30.5%
9	Prion Diseases	29.4%
10	Epidural Abscess	28.7%
11	Lewy Body Disease	27.4%
12	Subdural Effusion	26.6%
13	Myelitis	26.3%
14	Leukoencephalopathy, Progressive Multifocal	26.2%
15	Lupus Vasculitis, Central Nervous System	25.3%
16	Brain Abscess	25%
17	Brain Neoplasms	25%
18	Parkinson Disease	24.8%
19	Pneumocephalus	24.1%
20	Dandy-Walker Syndrome	22.7%
21	Dementia, Vascular	22.6%
22	Amyotrophic Lateral Sclerosis	22.4%
23	Ocular Motility Disorders	22.3%
24	Cyclophoria	22.3%
25	Subacute Combined Degeneration	21.9%
26	Motor Neuron Disease	21.1%
27	Parkinsonian Disorders	21%
28	Progressive supranuclear palsy	21%
29	Striatonigral Degeneration	20.8%
30	Huntington Disease	20.6%
31	Spinal Muscular Atrophy	20.6%
32	Progressive Muscular Atrophy	20.6%
33	Cerebellar Neoplasms	20.4%
34	Dystonia Musculorum Deformans	20.4%
35	Spinal Cord Neoplasms	20.1%
36	Stiff-Person Syndrome	20.1%
37	Meningitis	19.9%
38	Movement Disorders	19.9%
39	Pachymeningitis	19.9%
40	Spinal Cord Diseases	19.9%
41	Poliomyelitis	19.7%
42	Subacute Sclerosing Panencephalitis	19.6%
43	Pituitary Adenoma	19.5%
44	Pituitary Neoplasms	19.5%
45	Central Nervous System Neoplasms	19.4%
46	Epilepsy, Post-Traumatic	19.1%
47	Posterior Leukoencephalopathy Syndrome	18.8%
48	Posterior reversible encephalopathy syndrome	18.8%
49	Creutzfeldt-Jakob disease	18.8%
50	Basal Ganglia Cerebrovascular Disease	18.8%
51	Shy-Drager Syndrome	18.8%
52	Akinetic Mutism	18.6%
53	Anoxic Encephalopathy	18.6%
54	Basal Ganglia Diseases	18.6%
55	Brain Damage, Chronic	18.6%
56	Cerebellar Diseases	18.6%
57	Encephalomalacia	18.6%
58	Epilepsy	18.6%
59	Hydrocephalus	18.6%
60	Congenital Hydrocephalus	18.6%
61	Hypothalamic Diseases	18.6%
62	Thalamic Diseases	18.6%
63	Intracranial Hypertension	18.6%
64	Aura	18.6%
65	Leukoencephalopathy	18.6%
66	Neuroaxonal Dystrophies	18.6%
67	Headache Disorders	18.6%
68	Intracranial Hypotension	18.6%
69	Brain Edema	18.6%
70	Brain Hypoxia	18.6%
71	Aqueductal Stenosis	18.6%
72	Meningitis, Bacterial	18.4%
73	Meningitis, Fungal	18.4%
74	Marchiafava-Bignami Disease	18.4%
75	Brain Injuries	18.1%
76	Tuberous Sclerosis	17.7%
77	Meige Syndrome	17.7%
78	Supratentorial Neoplasms	17.4%
79	Toxoplasmosis, Cerebral	17.2%
80	Scrapie	16.9%
81	Presenile dementia	16.8%
82	Senile dementia	16.8%
83	Leukomalacia, Periventricular	16.7%
84	Ophthalmoplegic Migraine	16.7%
85	Nervous System Neoplasms	16.6%
86	Leukoencephalitis, Acute Hemorrhagic	16.5%
87	Vascular Headaches	16.5%
88	Hepatolenticular Degeneration	16.5%
89	Hypoxia-Ischemia, Brain	16.4%
90	Myoclonic Epilepsy	16.2%
91	Epilepsy, Temporal Lobe	16.2%
92	Epilepsy, Rolandic	16.2%
93	Benign Rolandic Epilepsy	16.2%
94	Spinal Cord Injuries	16.2%
95	Lafora Disease	16.2%
96	Unverricht-Lundborg Syndrome	16.2%
97	Tuberculosis, Meningeal	16.1%
98	Neuroleptic Malignant Syndrome	16.1%
99	Myelinolysis, Central Pontine	16.1%
100	Brain Diseases, Metabolic	16.1%
101	Cerebrovascular Disorders	16.1%
102	Cerebrovascular Insufficiency	16.1%
103	Dementia	16.1%
104	Central Nervous System Fungal Infections	16.1%
105	Brain Death	15.8%
106	Cranial nerve diseases	15.8%
107	Demyelinating Diseases	15.8%
108	Demyelination	15.8%
109	Neuromuscular Diseases	15.8%
110	Chronobiology Disorders	15.8%
111	Central Nervous System Cysts	15.8%
112	Asterixis	15.8%
113	Ballismus	15.8%
114	Tauopathies	15.5%
115	West Nile Fever	15.5%
116	MPTP Poisoning	15.4%
117	Restless Legs Syndrome	15.1%
118	Canavan Disease	15%
119	Alexander Disease	15%
120	Amblyopia	15%
121	Friedreich Ataxia	14.8%
122	Miller Fisher Syndrome	14.8%
123	Pseudorabies	14.7%
124	Basal Ganglia Hemorrhage	14.6%
125	Chronic Fatigue Syndrome	14.4%
126	Polyradiculoneuropathy	14.4%
127	Polyradiculoneuritis	14.4%
128	Central Nervous System Bacterial Infections	14.2%
129	Acoustic Neuroma	14.1%
130	Brain Hemorrhage, Traumatic	13.9%
131	Trauma, Nervous System	13.9%
132	Brain Stem Neoplasms	13.7%
133	Neurologic Manifestations	13.7%
134	Neurotoxicity Syndromes	13.7%
135	Juvenile Myoclonic Epilepsy	13.6%
136	Myoclonic Epilepsies, Progressive	13.6%
137	Encephalomyelitis, Acute Disseminated	13.6%
138	Carotid Artery Injuries	13.3%
139	Optic Nerve Glioma	13.2%
140	Progressive bulbar palsy	13.1%
141	Bulbar palsy	13.1%
142	Vasculitis, Central Nervous System	12.9%
143	Amnesia, Transient Global	12.9%
144	Pituitary Apoplexy	12.7%
145	Akathisia, Drug-Induced	12.6%
146	Meningeal Neoplasms	12.6%
147	Brain Infarction	12.6%
148	Cerebral Palsy	12.5%
149	Epilepsies, Partial	12.5%
150	Epilepsy, Generalized	12.5%
151	Pseudotumor Cerebri	12.5%
152	Hypertensive Encephalopathy	12.5%
153	Simple Partial Seizures	12.5%
154	Epilepsy, Reflex	12.5%
155	Headache Disorders, Primary	12.5%
156	Headache Disorders, Secondary	12.5%
157	Medication overuse headache	12.5%
158	Putaminal Hemorrhage	12.5%
159	Dyskinesia, Drug-Induced	12.4%
160	Meningioma	12.3%
161	Autonomic Dysreflexia	12.3%
162	Complex Regional Pain Syndromes	12.3%
163	Brain Injuries, Diffuse	12.2%
164	Traumatic Brain Injury	12.2%
165	Cerebellar Ataxia	12.2%
166	Sleep Wake Disorders	12.1%
167	Infarction, Middle Cerebral Artery	12.1%
168	Infarction, Anterior Cerebral Artery	12.1%
169	Infarction, Posterior Cerebral Artery	12.1%
170	Arachnoiditis	12%
171	Aseptic Meningitis	12%
172	Syringomyelia	12%
173	Essential Tremor	12%
174	Familial Tremor	12%
175	Pneumorrhachis	12%
176	Writer's Cramp	12%
177	Choroid Plexus Papilloma	11.9%
178	Multiple Endocrine Neoplasia	11.8%
179	Meningitis, Cryptococcal	11.8%
180	Meningitis, Listeria	11.7%
181	Meningitis, Haemophilus	11.7%
182	Meningitis, Pneumococcal	11.7%
183	Guillain-Barre Syndrome	11.6%
184	Abdominal Neoplasms	11.6%
185	Brain Diseases	11.6%
186	Head and Neck Neoplasms	11.6%
187	Soft Tissue Neoplasms	11.6%
188	Thoracic Neoplasms	11.6%
189	Persistent Vegetative State	11.5%
190	Pituitary Diseases	11.1%
191	Frontotemporal dementia	11%
192	Peripheral Nerve Injuries	10.9%
193	Myasthenia Gravis	10.8%
194	Carotid Artery Diseases	10.7%
195	Brain Ischemia	10.7%
196	Cerebrovascular accident	10.7%
197	Kluver-Bucy Syndrome	10.7%
198	Vasospasm, Intracranial	10.7%
199	Intracranial Arterial Diseases	10.7%
200	Hamartoma	10.7%
201	Neoplasms, Hormone-Dependent	10.7%
202	Neoplasms, Multiple Primary	10.7%
203	Precancerous Conditions	10.7%
204	Neoplasms, Second Primary	10.7%
205	Tuberculosis, Central Nervous System	10.7%
206	Cerebral Infarction	10.6%
207	Brain Stem Infarctions	10.6%
208	Moyamoya Disease	10.4%
209	Conus Medullaris Syndrome	10.4%
210	Spinal Cord Vascular Diseases	10.4%
211	Central Cord Syndrome	10.3%
212	Neuromyelitis Optica	10.3%
213	Central Nervous System Infection	10.2%
214	Digestive System Neoplasms	10.2%
215	Endocrine Gland Neoplasms	10.2%
216	Eye Neoplasms	10.2%
217	Chorea	10.2%
218	Bone neoplasms	10%
219	Skin Neoplasms	10%
220	Hematologic Neoplasms	10%
221	Adrenoleukodystrophy	10%
222	Splenic Neoplasms	10%
223	Mammary Neoplasms, Experimental	9.9%
224	Ataxia Telangiectasia	9.8%
225	Olfactory Nerve Injuries	9.8%
226	Sleep Disorders, Circadian Rhythm	9.8%
227	Mitochondrial Encephalomyopathies	9.8%
228	Limbic Encephalitis	9.8%
229	Subarachnoid Hemorrhage, Traumatic	9.8%
230	Carotid Artery, Internal, Dissection	9.8%
231	Causalgia	9.8%
232	Parathyroid Neoplasms	9.7%
233	Peritoneal Neoplasms	9.7%
234	Thyroid Neoplasm	9.7%
235	Thyroid carcinoma	9.7%
236	Botulism	9.6%
237	Lateral Medullary Syndrome	9.5%
238	Post-Traumatic Headache	9.5%
239	Tension Headache	9.5%
240	Epilepsy, Complex Partial	9.5%
241	Migraine Disorders	9.5%
242	Abdominal Migraine	9.5%
243	Status Migrainosus	9.5%
244	Cervicogenic Headache	9.5%
245	Reye Syndrome	9.4%
246	Neuroaspergillosis	9.4%
247	Intracranial Embolism and Thrombosis	9.4%
248	Hepatic Encephalopathy	9.4%
249	Prolactinoma	9.4%
250	Growth Hormone-Secreting Pituitary Adenoma	9.4%
251	MELAS Syndrome	9.3%
252	Refsum Disease	9.3%
253	Diffuse Axonal Injury	9.3%
254	Meningeal Carcinomatosis	9.3%
255	Charcot-Marie-Tooth Disease	9.3%
256	Cyst	9.3%
257	Neoplastic Processes	9.3%
258	Neoplastic Syndromes, Hereditary	9.3%
259	Pregnancy Complications, Neoplastic	9.3%
260	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.3%
261	Neoplasms, Experimental	9.2%
262	Myotonia Congenita	9.1%
263	Vertebral Artery Dissection	9%
264	Torticollis	8.9%
265	Auditory Perceptual Disorders	8.9%
266	Facial Nerve Injuries	8.9%
267	Dysautonomia	8.8%
268	Vagus Nerve Disorder	8.8%
269	Glossopharyngeal Neuralgia	8.8%
270	Abducens Nerve Diseases	8.8%
271	Heavy Metal Poisoning, Nervous System	8.8%
272	Neuromuscular Junction Diseases	8.8%
273	Trochlear Nerve Diseases	8.8%
274	Peripheral Nervous System Diseases	8.8%
275	Brain Concussion	8.8%
276	Pancreatic Neoplasm	8.8%
277	Sturge-Weber Syndrome	8.7%
278	Alice in Wonderland Syndrome	8.5%
279	Acanthoma	8.4%
280	Horner Syndrome	8.4%
281	Brain Diseases, Metabolic, Inborn	8.4%
282	Myotonic Dystrophy	8.3%
283	Neurosyphilis	8.3%
284	Brain Contusion	8.3%
285	Empty Sella Syndrome	8.2%
286	Hyperpituitarism	8.2%
287	Hypopituitarism	8.2%
288	Hypophysitis	8.2%
289	Carcinoma 256, Walker	8.2%
290	Multiple Sclerosis	8.2%
291	Tracheal Neoplasms	8.1%
292	Cerebral Arterial Diseases	8.1%
293	Vertebrobasilar Insufficiency	8.1%
294	Basilar Artery Stenosis	8.1%
295	Vertebral Artery Stenosis	8.1%
296	Intracranial Hemorrhage, Hypertensive	8.1%
297	Transient Cerebral Ischemia	8.1%
298	Neoplasms, Radiation-Induced	8.1%
299	Myasthenia Gravis, Autoimmune, Experimental	8%
300	Cluster Headache	8%
301	Migraine with Aura	8%
302	Familial Hemiplegic Migraine	8%
303	Chronic Paroxysmal Hemicrania	8%
304	SUNCT Syndrome	8%
305	Paroxysmal Hemicrania	8%
306	Carcinoma, Lobular	8%
307	Paraneoplastic Encephalomyelitis	7.9%
308	Reflex Sympathetic Dystrophy	7.9%
309	Nocturnal Myoclonus Syndrome	7.9%
310	Myopathy	7.8%
311	Optic Neuropathy	7.8%
312	Facial Nerve Diseases	7.7%
313	Craniocerebral Trauma	7.7%
314	Parasomnia	7.7%
315	Dyssomnias	7.7%
316	Jet Lag Syndrome	7.6%
317	Vestibulocochlear Nerve Diseases	7.6%
318	Decerebrate State	7.6%
319	Hemiparesis	7.6%
320	Hydranencephaly	7.6%
321	Meningism	7.6%
322	Neural Tube Defects	7.6%
323	Paresis	7.6%
324	Seizures	7.6%
325	Sensation Disorders	7.6%
326	Tethered Cord Syndrome	7.6%
327	Complex partial seizures	7.6%
328	Iniencephaly	7.6%
329	Craniorachischisis	7.6%
330	Exencephaly	7.6%
331	Monoparesis	7.6%
332	Septo-Optic Dysplasia	7.6%
333	Cortical Dysplasia	7.6%
334	Neurogenic Inflammation	7.6%
335	Gait Disorders, Neurologic	7.6%
336	Neuromuscular Manifestations	7.6%
337	Malformations of Cortical Development	7.6%
338	Carcinoma, Ehrlich Tumor	7.5%
339	Dermoid Cyst	7.5%
340	Sweating, Gustatory	7.5%
341	Auriculotemporal Syndrome	7.5%
342	Carcinoma, Lewis Lung	7.5%
343	Multiple Endocrine Neoplasia Type 1	7.5%
344	Wernicke Encephalopathy	7.5%
345	AIDS Dementia Complex	7.5%
346	Melanoma, Experimental	7.5%
347	Tardive Dyskinesia	7.5%
348	Trophoblastic Neoplasms	7.5%
349	Giant Cell Arteritis	7.5%
350	Temporal Arteritis	7.5%
351	Lyme Neuroborreliosis	7.5%
352	Leukemia, Experimental	7.4%
353	Ophthalmoplegia	7.4%
354	External Ophthalmoplegia	7.4%
355	Nelson Syndrome	7.3%
356	Esophageal Neoplasms	7.2%
357	Toxoplasmosis, Congenital	7.2%
358	Malaria, Cerebral	7.2%
359	Carotid Stenosis	7.1%
360	Intracranial Aneurysm	7.1%
361	Neurocysticercosis	7.1%
362	Encephalitis	7.1%
363	Retroperitoneal Neoplasms	7.1%
364	Intracranial Arteriosclerosis	7.1%
365	Cerebral Atherosclerosis	7.1%
366	neurofibroma	7.1%
367	Subarachnoid Hemorrhage	7.1%
368	Cerebral Arteriosclerosis	7.1%
369	Cerebral Hemorrhage	7.1%
370	Cerebral Thrombosis	7.1%
371	Intracranial Embolism	7.1%
372	Intracranial Thrombosis	7.1%
373	Spinal Cord Ischemia	7%
374	Neurofibrosarcoma	7%
375	Neoplasms, Neuroepithelial	6.9%
376	Gliomatosis cerebri	6.9%
377	Kernicterus	6.9%
378	Acrodynia	6.9%
379	Carcinoma, Pancreatic Ductal	6.9%
380	Hyperprolactinemia	6.9%
381	Subclavian Steal Syndrome	6.8%
382	Pick Disease of the Brain	6.8%
383	Pupil Disorders	6.8%
384	Neurobehavioral Manifestations	6.8%
385	Amyloid Neuropathies, Familial	6.8%
386	Leukemia, Radiation-Induced	6.7%
387	Vocal Cord Paralysis	6.7%
388	Uveomeningoencephalitic Syndrome	6.6%
389	Alstrom Syndrome	6.6%
390	Testicular Neoplasms	6.6%
391	Vertigo	6.6%
392	Alcohol-Induced Disorders, Nervous System	6.6%
393	Liver Neoplasms, Experimental	6.6%
394	Sarcoma, Experimental	6.6%
395	Neuroectodermal Tumors	6.6%
396	Thymoma	6.6%
397	Thyroid Nodule	6.5%
398	Brachial Plexus Neuritis	6.5%
399	Neuralgic Amyotrophy	6.5%
400	Medulloblastoma	6.4%
401	Hematoma, Subdural	6.4%
402	Hematoma, Epidural, Cranial	6.4%
403	Carotid Artery Thrombosis	6.3%
404	Nephroblastoma	6.3%
405	Mouth Neoplasms	6.2%
406	Vascular Neoplasms	6.2%
407	Thymus Neoplasms	6.2%
408	Cerebrospinal Fluid Otorrhea	6.2%
409	Cerebrospinal Fluid Rhinorrhea	6.2%
410	Neuritis, Autoimmune, Experimental	6.2%
411	Gait Ataxia	6.1%
412	Genital Neoplasms, Female	6.1%
413	melanoma	6.1%
414	Erythroplasia	6.1%
415	Follicular cyst	6.1%
416	leukemia	6.1%
417	Mucocele	6.1%
418	Neoplasms, Germ Cell and Embryonal	6.1%
419	Neoplasms, Glandular and Epithelial	6.1%
420	Pilonidal Cyst	6.1%
421	Thyroglossal Cyst	6.1%
422	Synovial Cyst	6.1%
423	Germ Cell Cancer	6.1%
424	Aberrant Crypt Foci	6.1%
425	Breast Neoplasms, Male	6.1%
426	Triple Negative Breast Neoplasms	6.1%
427	Waterhouse-Friderichsen Syndrome	6.1%
428	Acromegaly	6%
429	Coma, Post-Head Injury	6%
430	Retinoblastoma	6%
431	Voice Disorders	6%
432	Voice Disturbance	6%
433	Cerebral Amyloid Angiopathy	6%
434	Sinus Thrombosis, Intracranial	5.9%
435	Alcohol Withdrawal Seizures	5.9%
436	Smith-Magenis syndrome	5.9%
437	Dural Arteriovenous Fistula	5.9%
438	Neuronal Ceroid-Lipofuscinoses	5.9%
439	Leukoplakia, Oral	5.8%
440	Fabry Disease	5.8%
441	Tarsal Tunnel Syndrome	5.8%
442	Cauda Equina Syndrome	5.8%
443	Choriocarcinoma	5.8%
444	Multiple Sclerosis, Chronic Progressive	5.7%
445	Multiple Sclerosis, Relapsing-Remitting	5.7%
446	Vipoma	5.6%
447	Carcinosarcoma	5.6%
448	Hemangiosarcoma	5.6%
449	Leukemia L1210	5.6%
450	Leukemia P388	5.6%
451	lymphangiosarcoma	5.6%
452	Akathisia	5.5%
453	Restlessness	5.5%
454	Psychomotor Agitation	5.5%
455	Hematoma, Subdural, Intracranial	5.5%
456	Hematoma, Subdural, Chronic	5.5%
457	Hematoma, Subdural, Acute	5.5%
458	Neuritis	5.5%
459	Polyneuritis	5.5%
460	Radiculitis	5.5%
461	Polyneuropathy	5.5%
462	Mononeuritis	5.5%
463	Mononeuropathies	5.5%
464	Brachial Plexus Neuropathies	5.5%
465	Radiculopathy	5.5%
466	Mononeuropathy Multiplex	5.5%
467	Nerve Root Compression	5.5%
468	Adrenal Gland Neoplasms	5.4%
469	Gastrointestinal Neoplasms	5.4%
470	Genital Neoplasms, Male	5.4%
471	Liver neoplasms	5.4%
472	Uveal Neoplasms	5.4%
473	Lymphomatoid Granulomatosis	5.4%
474	Urologic Neoplasms	5.4%
475	Cockayne Syndrome	5.4%
476	Cavernous Sinus Thrombosis	5.4%
477	Sagittal Sinus Thrombosis	5.4%
478	Basal Cell Nevus Syndrome	5.4%
479	Sebaceous Gland Neoplasms	5.3%
480	Spinal Neoplasms	5.3%
481	Bone Marrow Neoplasms	5.3%
482	Anterior Spinal Artery Syndrome	5.3%
483	insulinoma	5.3%
484	Adenoma, Acidophil	5.3%
485	Ganglioneuroma	5.3%
486	Glioma	5.3%
487	Leukoplakia	5.3%
488	Lymphocele	5.3%
489	Pancreatic Cyst	5.3%
490	Reflex, Abnormal	5.3%
491	Hyporeflexia	5.3%
492	Hyperreflexia	5.3%
493	Malignant Glioma	5.3%
494	Barrett Esophagus	5.2%
495	Breast Cyst	5.2%
496	Histiocytic Disorders, Malignant	5.2%
497	Actinic keratosis	5.2%
498	Mediastinal Cyst	5.2%
499	Neoplasm Invasiveness	5.2%
500	Neoplasm Metastasis	5.2%
501	Neoplasm Recurrence, Local	5.2%
502	Parovarian Cyst	5.2%
503	Pericardial Cyst	5.2%
504	Thymic Cyst	5.2%
505	Carcinogenesis	5.2%
506	Myxoid cyst	5.2%
507	Metastasis	5.2%
508	Galactosemias	5.2%
509	Urea Cycle Disorders, Inborn	5.2%
510	Tyrosinemias	5.2%
511	Gastrinoma	5.1%
512	Glucagonoma	5.1%
513	Sarcoma 180	5.1%
514	Carpal Tunnel Syndrome	5.1%
515	Hepatocellular Adenoma	5.1%
516	Composite Lymphoma	5.1%
517	Paraneoplastic Syndromes	5.1%
518	Sciatica	5.1%
519	Gait Apraxia	5%
520	Nose Neoplasms	5%
521	Optic Atrophy, Hereditary, Leber	5%
522	Menkes Kinky Hair Syndrome	5%
523	Leukemia, Plasma Cell	4.9%
524	Adenomatous Polyposis Coli	4.9%
525	Carcinoid Tumor	4.8%
526	Neurilemmoma	4.8%
527	Hutchinson's Melanotic Freckle	4.8%
528	Melanoma, Amelanotic	4.8%
529	Homocystinuria	4.7%
530	Palatal Neoplasms	4.7%
531	Myositis	4.7%
532	Optic Atrophy	4.7%
533	Optic Neuritis	4.7%
534	Papilledema	4.7%
535	Strabismus	4.7%
536	Tolosa-Hunt Syndrome	4.7%
537	Isaacs syndrome	4.7%
538	Arsenic Poisoning	4.7%
539	Myotonic Disorders	4.7%
540	Myasthenic Syndromes, Congenital	4.7%
541	Leigh Disease	4.7%
542	Diabetic Neuropathies	4.7%
543	Facial Injuries	4.7%
544	Facial Neuralgia	4.7%
545	Diabetic Amyotrophy	4.7%
546	Diabetic Autonomic Neuropathy	4.7%
547	Sleep Talking	4.7%
548	Manganese Poisoning	4.7%
549	Sleep Disorders, Intrinsic	4.7%
550	Orthostatic intolerance	4.7%
551	Anosmia	4.7%
552	Ataxia	4.7%
553	Athetosis	4.7%
554	Catalepsy	4.7%
555	Dystonia	4.7%
556	Hemiplegia	4.7%
557	Locked-In Syndrome	4.7%
558	Meningomyelocele	4.7%
559	Muscle Hypertonia	4.7%
560	Muscle hypotonia	4.7%
561	Myoclonus	4.7%
562	Myotonia	4.7%
563	Neuralgia	4.7%
564	Paraplegia	4.7%
565	Pseudobulbar Palsy	4.7%
566	Quadriplegia	4.7%
567	Spasm	4.7%
568	Spastic Paraplegia	4.7%
569	Status Epilepticus	4.7%
570	Taste Disorders	4.7%
571	Tremor	4.7%
572	Spina Bifida	4.7%
573	Monoplegia	4.7%
574	Hypokinesia	4.7%
575	Paraparesis	4.7%
576	Bradykinesia	4.7%
577	Waxy flexibility	4.7%
578	Action Tremor	4.7%
579	Resting Tremor	4.7%
580	Dysosmia	4.7%
581	Quadriparesis	4.7%
582	Mercury Poisoning, Nervous System	4.7%
583	Olfaction Disorders	4.7%
584	Myokymia	4.7%
585	Lead Poisoning, Nervous System	4.7%
586	Vestibular Neuronitis	4.7%
587	Somatosensory Disorders	4.7%
588	Neuropathic pain	4.7%
589	Hyperkinesia	4.7%
590	Intention tremor	4.7%
591	Basal cell carcinoma	4.7%
592	Carcinoma, Papillary	4.7%
593	Squamous cell carcinoma	4.7%
594	Chondrosarcoma	4.7%
595	Craniopharyngioma	4.7%
596	Cystadenoma	4.7%
597	leiomyosarcoma	4.7%
598	liposarcoma	4.7%
599	Mesothelioma	4.7%
600	synovial sarcoma	4.7%
601	Neuroectodermal Tumor, Melanotic	4.7%
602	Angiomyolipoma	4.7%
603	Clear Cell Sarcoma of Soft Tissue	4.7%
604	Alveolar Soft Part Sarcoma	4.7%
605	Neuroendocrine Tumors	4.7%
606	Sarcoma, Myeloid	4.7%
607	Carcinoma, Basal Cell	4.7%
608	Lymphoma	4.6%
609	Leydig Cell Tumor	4.6%
610	Corpus Luteum Cyst	4.5%
611	Ovarian Cysts	4.5%
612	Cubital Tunnel Syndrome	4.5%
613	Astrocytoma	4.4%
614	Ependymoma	4.4%
615	oligodendroglioma	4.4%
616	Ganglioglioma	4.4%
617	gliosarcoma	4.4%
618	Anaplastic astrocytoma	4.4%
619	Anaplastic Oligodendroglioma	4.4%
620	ovarian neoplasm	4.3%
621	Hand-Arm Vibration Syndrome	4.3%
622	Malignant Carcinoid Syndrome	4.2%
623	Vision Disorders	4.2%
624	Metamorphopsia	4.2%
625	Visual Impairment	4.2%
626	Fibromyalgia	4.2%
627	Optic Neuropathy, Ischemic	4.2%
628	Anterior Ischemic Optic Neuropathy	4.2%
629	Medial Tibial Stress Syndrome	4.2%
630	Cystadenocarcinoma	4.2%
631	Fibrosarcoma	4.2%
632	Osteosarcoma	4.2%
633	Mucoepidermoid Carcinoma	4.2%
634	Facial Hemiatrophy	4.1%
635	Melkersson-Rosenthal Syndrome	4.1%
636	Mitochondrial Myopathies	4.1%
637	Anisocoria	4.1%
638	Confusion	4.1%
639	Facial paralysis	4.1%
640	Lethargy	4.1%
641	Memory Disorders	4.1%
642	Muscle Cramp	4.1%
643	Perceptual Disorders	4.1%
644	Psychomotor Disorders	4.1%
645	Tonic Pupil	4.1%
646	Eosinophilia-Myalgia Syndrome	4.1%
647	Anhedonia	4.1%
648	Disorientation	4.1%
649	Facial Paresis	4.1%
650	Memory Loss	4.1%
651	Hemisensory Neglect	4.1%
652	Dysacusis	4.1%
653	granulosa cell tumor	4.1%
654	Carcinoma, Ovarian Epithelial	4.1%
655	Mesoblastic Nephroma	4.1%
656	Sleep Bruxism	4.1%
657	Zollinger-Ellison syndrome	4.1%
658	Anencephaly	4.1%
659	Meningocele	4.1%
660	Muscular Atrophy	4.1%
661	Respiratory Paralysis	4.1%
662	Encephalocele	4.1%
663	Choledochal Cyst	4.1%
664	Tetany	4.1%
665	Classical Lissencephalies and Subcortical Band Heterotopias	4%
666	Glioblastoma	4%
667	Neuroblastoma	4%
668	Glioblastoma Multiforme	4%
669	Peutz-Jeghers Syndrome	4%
670	Carbamoyl-Phosphate Synthase I Deficiency Disease	4%
671	Endometrial Stromal Sarcoma	4%
672	Adenofibroma	3.9%
673	Fibroadenoma	3.9%
674	Malignant Fibrous Histiocytoma	3.9%
675	Adenoma	3.8%
676	Ameloblastoma	3.8%
677	Angiokeratoma	3.8%
678	Carcinoma	3.8%
679	Chordoma	3.8%
680	Hemangioma	3.8%
681	hemangiopericytoma	3.8%
682	Lymphangioma	3.8%
683	Mesenchymoma	3.8%
684	Nevus	3.8%
685	Teratoma	3.8%
686	Hepatoblastoma	3.8%
687	Mixed Tumor, Mullerian	3.8%
688	Germinoma	3.8%
689	Teratocarcinoma	3.8%
690	Angiofibroma	3.8%
691	Sarcoma	3.8%
692	Epithelioma	3.8%
693	Ganglioneuroblastoma	3.8%
694	Zellweger Syndrome	3.8%
695	Sciatic Neuropathy	3.8%
696	Ulnar Neuropathies	3.8%
697	Lesion of Sciatic Nerve	3.8%
698	Ulnar Neuritis	3.8%
699	Radial nerve compression	3.8%
700	Radial Tunnel Syndrome	3.8%
701	Peroneal Neuropathies	3.8%
702	Radial Neuropathy	3.8%
703	Median Neuropathy	3.8%
704	Sciatic Nerve Palsy	3.8%
705	Femoral Neuropathy	3.8%
706	Tibial Neuropathy	3.8%
707	Ulnar Nerve Palsy	3.8%
708	Postural Orthostatic Tachycardia Syndrome	3.8%
709	Radial nerve palsy	3.8%
710	Ear Neoplasms	3.7%
711	Eyelid Neoplasms	3.7%
712	Lung Neoplasms	3.7%
713	Pleural Neoplasms	3.7%
714	Duane Retraction Syndrome	3.7%
715	Bowen's Disease	3.7%
716	Consciousness Disorders	3.7%
717	Mental Retardation	3.7%
718	Paraganglioma	3.7%
719	Rhabdomyosarcoma	3.7%
720	Muscle Weakness	3.7%
721	Giant Cell Tumor of Bone	3.7%
722	Depressed Level of Consciousness	3.7%
723	Mental deficiency	3.7%
724	Intellectual Disability	3.7%
725	Mobius Syndrome	3.7%
726	Bell Palsy	3.7%
727	Salivary Gland Neoplasms	3.7%
728	Tongue Neoplasms	3.7%
729	Catatonia	3.7%
730	Herpes Zoster Oticus	3.7%
731	Familial Periodic Paralysis	3.7%
732	Uterine Neoplasms	3.7%
733	Vaginal Neoplasms	3.7%
734	Vulvar Neoplasms	3.7%
735	Uterine Cancer	3.7%
736	Fallopian Tube Neoplasms	3.7%
737	Aphonia	3.6%
738	Sleep Deprivation	3.6%
739	Dysphonia	3.6%
740	Hydatidiform Mole	3.6%
741	Glycogen storage disease type II	3.6%
742	Lymphangioleiomyomatosis	3.6%
743	Adrenocortical carcinoma	3.6%
744	Alexia	3.6%
745	Kearns-Sayre syndrome	3.6%
746	Dyslexia	3.6%
747	Carcinoid Heart Disease	3.5%
748	Dermatofibrosarcoma	3.5%
749	Dermatofibrosarcoma Protuberans	3.5%
750	Denys-Drash Syndrome	3.4%
751	Pharyngeal Neoplasms	3.4%
752	Thoracic Outlet Syndrome	3.3%
753	Pancreatic Pseudocyst	3.3%
754	Plasmacytoma	3.3%
755	Bile Duct Neoplasms	3.3%
756	gallbladder neoplasm	3.3%
757	Intestinal Neoplasms	3.3%
758	Penile Neoplasms	3.3%
759	Prostatic Neoplasms	3.3%
760	Stomach Neoplasms	3.3%
761	Myalgia	3.3%
762	Esotropia	3.3%
763	Exotropia	3.3%
764	Malignant histiocytosis	3.3%
765	Hypotension, Orthostatic	3.3%
766	Lymphatic Metastasis	3.3%
767	Neoplasms, Unknown Primary	3.3%
768	Sleep Apnea Syndromes	3.3%
769	Polymyositis	3.3%
770	Leukemic Infiltration	3.3%
771	Histiocytic sarcoma	3.3%
772	Neoplasm Micrometastasis	3.3%
773	Post-Exercise Hypotension	3.3%
774	Disorders of Excessive Somnolence	3.3%
775	Sleep Initiation and Maintenance Disorders	3.3%
776	Night Terrors	3.3%
777	Somnambulism	3.3%
778	Trigeminal Nerve Disorder	3.3%
779	Transient Insomnia	3.3%
780	Sleep Paralysis	3.3%
781	Chronic Insomnia	3.3%
782	REM Sleep Behavior Disorder	3.3%
783	Hypersomnia	3.3%
784	Polycythemia Vera	3.2%
785	Dermal Sinus	3.2%
786	Dysgeusia	3.2%
787	Formication	3.2%
788	Hyperalgesia	3.2%
789	Hyperesthesia	3.2%
790	Hypesthesia	3.2%
791	Language Disorders	3.2%
792	Numbness	3.2%
793	Paresthesia	3.2%
794	Paraparesis, Spastic	3.2%
795	Spina Bifida Cystica	3.2%
796	Trismus	3.2%
797	Spina Bifida Occulta	3.2%
798	Epilepsia Partialis Continua	3.2%
799	Hypogeusia	3.2%
800	Brown-Sequard Syndrome	3.2%
801	Lissencephaly	3.2%
802	Polymicrogyria	3.2%
803	Pachygyria	3.2%
804	Schizencephaly	3.2%
805	Lockjaw	3.2%
806	Allodynia	3.2%
807	Lead Poisoning, Nervous System, Childhood	3.2%
808	Lead Poisoning, Nervous System, Adult	3.2%
809	Periventricular Nodular Heterotopia	3.2%
810	Ageusia	3.2%
811	Pheochromocytoma	3.2%
812	Alveolar rhabdomyosarcoma	3.2%
813	Renal Cell Carcinoma	3.2%
814	Papillary Renal Cell Carcinoma	3.2%
815	Gaucher Disease	3%
816	Laryngeal neoplasm	3%
817	Aicardi's syndrome	3%
818	Hoarseness	3%
819	Polyradiculopathy	3%
820	Alcohol Withdrawal Delirium	3%
821	Nasopharyngeal carcinoma	3%
822	Bladder Neoplasm	2.9%
823	Kidney Neoplasm	2.9%
824	Ureteral Neoplasms	2.9%
825	Urethral Neoplasms	2.9%
826	Eye Injuries	2.9%
827	Carcinoma, Endometrioid	2.9%
828	Muscular Dystrophy	2.9%
829	Congenital nystagmus	2.9%
830	Orbital Myositis	2.9%
831	Bronchial Neoplasms	2.9%
832	Diplopia	2.9%
833	Muscle Rigidity	2.9%
834	Muscle Spasticity	2.9%
835	Scotoma	2.9%
836	Photophobia	2.9%
837	Cogwheel Rigidity	2.9%
838	Hemifacial Spasm	2.9%
839	Amaurosis	2.9%
840	Blindness	2.9%
841	Nuchal Rigidity	2.9%
842	Pyomyositis	2.9%
843	Multiple Pulmonary Nodules	2.9%
844	Hodgkin Disease	2.9%
845	Lymphoma, Non-Hodgkin	2.9%
846	Agnosia	2.9%
847	Apraxias	2.9%
848	Hallucinations	2.9%
849	Hemianopsia	2.9%
850	Hyperacusis	2.9%
851	Tinnitus	2.9%
852	Visual Agnosia	2.9%
853	Anosognosia	2.9%
854	Wernicke-Korsakoff Syndrome	2.9%
855	Phonophobia	2.9%
856	Hearing Loss	2.9%
857	Polycystic Ovary Syndrome	2.8%
858	Sarcopenia	2.8%
859	Endometrial Neoplasms	2.8%
860	Xeroderma Pigmentosum	2.8%
861	Tay-Sachs Disease	2.8%
862	Holoprosencephaly	2.7%
863	Adenocarcinoma	2.7%
864	Carcinoma in Situ	2.7%
865	Carcinoma, Transitional Cell	2.7%
866	Phyllodes Tumor	2.7%
867	Dysgerminoma	2.7%
868	Hemangioendothelioma	2.7%
869	Lipoma	2.7%
870	Myoma	2.7%
871	Myxoma	2.7%
872	Neuroma	2.7%
873	Papilloma	2.7%
874	Pseudomyxoma Peritonei	2.7%
875	Seminoma	2.7%
876	Papillomatosis	2.7%
877	Angiolipoma	2.7%
878	Myelolipoma	2.7%
879	Neoplasms, Bone Tissue	2.7%
880	Neoplasms, Fibrous Tissue	2.7%
881	Smooth Muscle Tumor	2.7%
882	Adenomatosis, Pulmonary	2.7%
883	Adenomatous Polyps	2.7%
884	Carcinoma, Large Cell	2.7%
885	Carcinoma, Small Cell	2.7%
886	Desmoplastic Small Round Cell Tumor	2.7%
887	Chondroma	2.7%
888	Enchondroma	2.7%
889	Niemann-Pick Disease, Type C	2.7%
890	Amnesia	2.6%
891	Delirium	2.6%
892	Dissociative Amnesia	2.6%
893	Color blindness	2.6%
894	Global Amnesia	2.6%
895	Cri-du-Chat Syndrome	2.6%
896	Down Syndrome	2.6%
897	Primary amyloidosis	2.6%
898	Trisomy 21	2.6%
899	Sleep Apnea, Obstructive	2.6%
900	Sleep Apnea, Central	2.6%
901	Hypopharyngeal Neoplasms	2.6%
902	Pleural Effusion, Malignant	2.6%
903	Hypopharyngeal Cancer	2.6%
904	Narcolepsy	2.5%
905	Trigeminal Neuralgia	2.5%
906	Kleine-Levin Syndrome	2.5%
907	POEMS Syndrome	2.5%
908	Agraphia	2.5%
909	Anomia	2.5%
910	Cluttering	2.5%
911	Language Development Disorders	2.5%
912	Speech Disorders	2.5%
913	Syncope	2.5%
914	Stupor	2.5%
915	Dysgraphia	2.5%
916	Presyncope	2.5%
917	Dyslalia	2.5%
918	Williams Syndrome	2.5%
919	Microcephaly	2.5%
920	Macrocephaly	2.5%
921	Hypokalemic periodic paralysis	2.5%
922	Parotid Neoplasms	2.5%
923	Prostatic Neoplasms, Castration-Resistant	2.5%
924	Porencephaly	2.5%
925	Leukemia, Myelomonocytic, Chronic	2.3%
926	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.3%
927	Prader-Willi Syndrome	2.3%
928	Phantom pain	2.3%
929	Phantom Limb Pain	2.3%
930	Cecal Neoplasms	2.3%
931	Duodenal Neoplasms	2.3%
932	Eye Burns	2.3%
933	Welander Distal Myopathy	2.2%
934	Amaurosis Fugax	2.2%
935	Blindness, Cortical	2.2%
936	Dyscalculia	2.2%
937	Rett Syndrome	2.2%
938	Deafness	2.2%
939	Hearing Loss, Sudden	2.2%
940	Gerstmann Syndrome	2.2%
941	Hearing Loss, Bilateral	2.2%
942	Hearing Loss, High-Frequency	2.2%
943	Hearing Loss, Mixed Conductive-Sensorineural	2.2%
944	Prosopagnosia	2.2%
945	Apraxia, Ideomotor	2.2%
946	Charles Bonnet Syndrome	2.2%
947	Hearing Loss, Unilateral	2.2%
948	Complete Hearing Loss	2.2%
949	Alien Hand Syndrome	2.2%
950	Deaf Mutism	2.2%
951	Cataplexy	2.2%
952	Aphasia	2.2%
953	Articulation Disorders	2.2%
954	Echolalia	2.2%
955	Stuttering	2.2%
956	Dysphasia	2.2%
957	Adenoid Cystic Carcinoma	2.2%
958	fibroma	2.2%
959	Fibromatosis	2.2%
960	Osteoblastoma	2.2%
961	Osteoma	2.2%
962	Rhabdomyoma	2.2%
963	Chondromatosis	2.2%
964	Adenocarcinoma, Clear Cell	2.2%
965	Cholangiocarcinoma	2.2%
966	Cervical Intraepithelial Neoplasia	2.2%
967	Hemangioblastoma	2.2%
968	Lymphoma, Extranodal NK-T-Cell	2.2%
969	Tonsillar Neoplasms	2.2%
970	Nasopharyngeal Neoplasms	2.1%
971	Waldenstrom Macroglobulinemia	2.1%
972	Multiple Myeloma	2.1%
973	Mastocytosis	2.1%
974	Colorectal Neoplasms	2.1%
975	Cell Transformation, Viral	2.1%
976	Gastrointestinal Stromal Tumors	2%
977	Hemangioma, Cavernous	2%
978	Leukemia, T-Cell	2%
979	Leukemia, B-Cell	2%
980	Dermatomyositis	2%
981	Lymphoma, Follicular	2%
982	T-Cell Lymphoma	2%
983	Mantle cell lymphoma	2%
984	Corneal Scar	2%
985	Dysarthria	2%
986	Muscular Dystrophy, Duchenne	2%
987	Retrograde amnesia	2%
988	Amnesia, Anterograde	2%
989	Mutism	1.9%
990	Selective Mutism	1.9%
991	Appendiceal Neoplasms	1.9%
992	Colonic Neoplasms	1.9%
993	Rectal Neoplasms	1.9%
994	Paranasal Sinus Neoplasms	1.9%
995	Rubinstein-Taybi Syndrome	1.9%
996	Fibromatosis, Aggressive	1.9%
997	Fibromatosis, Abdominal	1.9%
998	Klatskin Tumor	1.9%
999	Mastocytoma	1.9%
1000	Mastocytosis, Systemic	1.9%
1001	Leukemia, Myeloid, Chronic-Phase	1.9%
1002	Fragile X Syndrome	1.8%
1003	Alexia, Pure	1.8%
1004	Corneal Perforation	1.7%
1005	Maxillary Sinus Neoplasms	1.6%
1006	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
1007	Leukemia, Large Granular Lymphocytic	1.6%
1008	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
1009	Lymphoma, T-Cell, Cutaneous	1.6%
1010	Lymphoma, AIDS-Related	1.6%
1011	Enteropathy-Associated T-Cell Lymphoma	1.6%
1012	Primary Effusion Lymphoma	1.6%
1013	Anus Neoplasms	1.6%
1014	Sigmoid Neoplasms	1.6%
1015	Dupuytren Contracture	1.4%
1016	Urticaria Pigmentosa	1.4%
1017	Mycosis Fungoides	1.4%
1018	Lymphomatoid Papulosis	1.4%
1019	Plasmablastic lymphoma	1.4%
1020	Mucopolysaccharidosis II	1.4%
1021	Burkitt Lymphoma	1.3%
1022	Sezary Syndrome	1.1%
1023	Radicular Cyst	1.1%

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