MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rheumatoid Nodule

(UMLS:C0035450)

Definition:: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
UMLS ID:: C0035450
MeSH ID:: D012218

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.550.114.154.683|C05.799.114.683

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.775.099.683

Synonym(s)

Rheumatoid Nodule

RHEUMATOID NODULOSIS

Rheumatoid nodule

Rheumatoid nodule, NOS

Rheumatoid nodulosis

Subcutaneous rheumatoid nodule

node; rheumatoid

nodule; rheumatoid

rheumatoid nodule

10.

rheumatoid nodules

11.

rheumatoid; node

12.

rheumatoid; nodule

Associated Drug(s)

	Name	Number of Reports	Data Source
1	tofacitinib	FAERS: 24	US FAERS
2	Methotrexate	FAERS: 21	US FAERS
3	Methotrexate	FAERS: 10 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
4	Leflunomide	FAERS: 7	OFFSIDES US FAERS
5	Teriparatide	FAERS: 3	US FAERS
6	Celecoxib	FAERS: 2	US FAERS
7	Hydroxychloroquine	FAERS: 2	US FAERS
8	Anastrozole	FAERS: 1	US FAERS
9	Everolimus	FAERS: 1	US FAERS
10	Gabapentin	FAERS: 1	US FAERS
11	Letrozole	FAERS: 1	OFFSIDES US FAERS
12	Liraglutide	FAERS: 1	US FAERS
13	Methylphenidate	FAERS: 1	US FAERS
14	Rosuvastatin Calcium	FAERS: 1	US FAERS
15	diclofenac hydroxyethylpyrrolidine	FAERS: 1	US FAERS
16	rofecoxib	FAERS: 1	US FAERS
17	Acetylcysteine		OFFSIDES
18	Amiloride		OFFSIDES
19	Calcium Citrate		OFFSIDES
20	Carisoprodol		OFFSIDES
21	Codeine		OFFSIDES
22	Cortisone		OFFSIDES
23	Digoxin		OFFSIDES
24	Dioctyl Sulfosuccinic Acid		OFFSIDES
25	Dothiepin		OFFSIDES
26	Estradiol		OFFSIDES
27	Etoricoxib		OFFSIDES
28	Gemfibrozil		OFFSIDES
29	Glipizide		OFFSIDES
30	Ibandronic Acid		OFFSIDES
31	Niacinamide		OFFSIDES
32	Norfloxacin		OFFSIDES
33	Oxaprozin		OFFSIDES
34	Perindopril		OFFSIDES
35	Phenprocoumon		OFFSIDES
36	Pilocarpine		OFFSIDES
37	Pravastatin		OFFSIDES
38	Spironolactone		OFFSIDES
39	Thiamine		OFFSIDES
40	Vitamin A		OFFSIDES
41	cyclobenzaprine		OFFSIDES
42	ropinirole		OFFSIDES
43	urapidil		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Felty Syndrome	43.9%
2	Rheumatoid Vasculitis	38.4%
3	Sicca Syndrome	34.2%
4	Sjogren's Syndrome	34.2%
5	Juvenile arthritis	33.2%
6	Polymyalgia Rheumatica	30.9%
7	Rheumatic Fever	26.5%
8	Gout	25.2%
9	Periarthritis	25%
10	Osteoarthritis, Spine	24.6%
11	Cartilage Diseases	23.6%
12	Chondromalacia	23.6%
13	Contracture	21.6%
14	Osteoarthropathy, Secondary Hypertrophic	21.6%
15	Osteoarthritis, Knee	20.9%
16	Arthrogryposis	20.9%
17	Sacroiliitis	20.5%
18	Arthritis, Psoriatic	20.1%
19	Fibromyalgia	19.1%
20	Metatarsalgia	17.9%
21	Bursitis	17.5%
22	Joint Instability	17.5%
23	Synovitis	17.5%
24	Joint laxity	17.5%
25	Frozen shoulder	17.5%
26	Patellofemoral Pain Syndrome	17.5%
27	Osteochondritis	17.4%
28	Arthritis, Infectious	16.7%
29	Foot Diseases	16.7%
30	Arthritis, Gouty	16.6%
31	Arthritis, Experimental	16.4%
32	Bone Diseases	16.4%
33	Fasciitis	16.4%
34	Foot Deformities	16.4%
35	Pectus carinatum	16%
36	Ankylosing spondylitis	15.9%
37	Arthritis, Reactive	15.5%
38	Fasciitis, Plantar	14.9%
39	Hemarthrosis	14%
40	Temporomandibular Joint Disorders	14%
41	Spondylarthropathies	13.6%
42	Jaw Diseases	13.6%
43	Lupus Erythematosus, Cutaneous	13.5%
44	Panniculitis	13.5%
45	Systemic Scleroderma	13.5%
46	Morphea	13.5%
47	Tietze's Syndrome	13.3%
48	Myopathy	13.2%
49	Hip Contracture	13.2%
50	Ischemic contracture	12.7%
51	Collagen Diseases	12.5%
52	Mixed Connective Tissue Disease	12.5%
53	Mucinoses	12.5%
54	Dupuytren Contracture	12.1%
55	Dermatomyositis	11.9%
56	Nail-Patella Syndrome	11.5%
57	Temporomandibular Joint Dysfunction Syndrome	10.6%
58	Lupus Erythematosus, Systemic	10.1%
59	Overlap syndrome	10.1%
60	Cutis Laxa	10%
61	Pectus excavatum	10%
62	Arthralgia	9.9%
63	Platybasia	9.9%
64	Polyarthralgia	9.9%
65	Panniculitis, Lupus Erythematosus	9.3%
66	Bone Diseases, Developmental	9.2%
67	Hyperostosis	9.2%
68	Myofascial Pain Syndromes	9.2%
69	Osteitis	9.2%
70	Osteitis Deformans	9.2%
71	Osteochondrosis	9.2%
72	Rhabdomyolysis	9.2%
73	Spinal Diseases	9.2%
74	Klippel-Feil Syndrome	8.8%
75	Synostosis	8.8%
76	Arthropathy	8.6%
77	Laryngomalacia	8.5%
78	Talipes	8.4%
79	Noonan Syndrome	8.1%
80	Lupus Erythematosus, Discoid	7.9%
81	Scleroderma, Limited	7.9%
82	Osteogenesis Imperfecta	7.7%
83	Gigantism	7.7%
84	Spinal Neoplasms	7.7%
85	Spondylitis	7.7%
86	Bone Diseases, Endocrine	7.6%
87	Bone Diseases, Infectious	7.4%
88	Bone neoplasms	7.4%
89	Compartment syndromes	7.4%
90	Maxillary Diseases	7.4%
91	Osteopenia	7.4%
92	Tendinitis	7.4%
93	Tendinopathy	7.4%
94	Scleromyxedema	7.4%
95	Marfan Syndrome	7.4%
96	Bone Resorption	7.3%
97	Myositis	7.3%
98	Limb Deformities, Congenital	7.3%
99	Isaacs syndrome	7.3%
100	Craniofacial Abnormalities	7.3%
101	Aseptic Necrosis of Bone	7.3%
102	Myotonic Disorders	7.3%
103	Craniosynostosis	7.3%
104	Syndactyly	7.3%
105	Brachycephaly	7.3%
106	Hip Dislocation	7.3%
107	Shoulder Dislocation	7.3%
108	Hip Dysplasia	7.3%
109	Cellulitis	7.1%
110	Pseudoxanthoma Elasticum	7%
111	Acrocephalosyndactylia	6.7%
112	Craniofacial Dysostosis	6.5%
113	Rheumatism	6.2%
114	Congenital clubfoot	6.2%
115	Vertical Talus	6.2%
116	Medial Tibial Stress Syndrome	6.2%
117	Mitochondrial Myopathies	6.1%
118	Muscle Cramp	6.1%
119	Eosinophilia-Myalgia Syndrome	6.1%
120	Gastroschisis	6.1%
121	Bronchomalacia	6.1%
122	Tracheomalacia	6.1%
123	Muscle Rigidity	6%
124	Muscle Spasticity	6%
125	Cogwheel Rigidity	6%
126	Nuchal Rigidity	6%
127	Shoulder Pain	6%
128	Mesenteric Panniculitis	6%
129	Panniculitis, Peritoneal	6%
130	Orbital Cellulitis	6%
131	Myxoid cyst	6%
132	Myxedema	5.9%
133	Jaw Abnormalities	5.9%
134	Ainhum	5.7%
135	Bunion	5.7%
136	Dysostoses	5.7%
137	Fibrodysplasia Ossificans Progressiva	5.7%
138	Myoglobinuria	5.7%
139	Myositis Ossificans	5.7%
140	Spinal Stenosis	5.7%
141	Spondylosis	5.7%
142	Tenosynovitis	5.7%
143	Intervertebral Disc Degeneration	5.7%
144	Necrobiosis Lipoidica Diabeticorum	5.6%
145	Chronic Fatigue Syndrome	5.4%
146	Poland Syndrome	5.4%
147	Discitis	5.4%
148	Erythema Induratum	5.4%
149	Prognathism	5.3%
150	Giant Cell Epulis	5.3%
151	Muscle Weakness	5.3%
152	Musculoskeletal Pain	5.2%
153	Familial Periodic Paralysis	5.2%
154	Arthritis	5%
155	Polyarthritis	5%
156	Congenital Hypothyroidism	5%
157	Pyoderma Gangrenosum	4.9%
158	Granuloma Annulare	4.9%
159	Keloid	4.9%
160	Homocystinuria	4.9%
161	Multiple Epiphyseal Dysplasia	4.7%
162	Osteochondrodysplasias	4.7%
163	Tuberculosis, Spinal	4.6%
164	Anterior Compartment Syndrome	4.6%
165	Osteomyelitis	4.6%
166	Osteoporosis	4.6%
167	Periostitis	4.6%
168	Enthesopathy	4.6%
169	Bone Demineralization, Pathologic	4.6%
170	Post-Traumatic Osteoporosis	4.6%
171	Abdominal Compartment Syndrome	4.6%
172	Alveolar Bone Loss	4.6%
173	Amelia	4.6%
174	Arachnodactyly	4.6%
175	Ectromelia	4.6%
176	Femur Head Necrosis	4.6%
177	Hemimelia	4.6%
178	Phocomelia	4.6%
179	Sirenomelia	4.6%
180	Polymyositis	4.6%
181	Polydactyly	4.6%
182	Brachydactyly	4.6%
183	Plagiocephaly	4.6%
184	Lower Extremity Deformities, Congenital	4.6%
185	Upper Extremity Deformities, Congenital	4.6%
186	Osteolysis	4.6%
187	Eosinophilic Granuloma	4.5%
188	Myalgia	4.5%
189	Antley-Bixler Syndrome Phenotype	4.5%
190	Rheumatoid Arthritis	4.3%
191	Lupus Nephritis	4.2%
192	Breast Diseases	4.2%
193	Dermatitis	4.2%
194	Exanthema	4.2%
195	Facial Dermatoses	4.2%
196	Hair Diseases	4.2%
197	Hand Dermatoses	4.2%
198	keratoacanthoma	4.2%
199	Keratosis	4.2%
200	Nail Diseases	4.2%
201	Photosensitivity Disorders	4.2%
202	Prurigo	4.2%
203	Pyoderma	4.2%
204	Rosacea	4.2%
205	Sebaceous Gland Diseases	4.2%
206	Skin Diseases, Vesiculobullous	4.2%
207	Skin Ulcer	4.2%
208	Sweat Gland Diseases	4.2%
209	Skin Diseases, Papulosquamous	4.2%
210	Skin Diseases, Vascular	4.2%
211	Acneiform Eruptions	4.2%
212	Mandibulofacial Dysostosis	4.2%
213	Ocular Rosacea	4.2%
214	Subcorneal pustular dermatosis	4.2%
215	Erythematotelangiectatic Rosacea	4.2%
216	Papulopustular Rosacea	4.2%
217	Chronic Actinic Dermatitis	4.2%
218	Chondrodysplasia Punctata	4.1%
219	Enchondromatosis	4.1%
220	Lordosis	4.1%
221	Osteosclerosis	4.1%
222	Spondylolysis	4.1%
223	kyphosis	4.1%
224	Kashin-Beck Disease	4.1%
225	Dwarfism	4%
226	Goldenhar Syndrome	4%
227	Palatal Neoplasms	4%
228	Micrognathism	4%
229	Pierre Robin Syndrome	4%
230	Acne Vulgaris	3.9%
231	Contact Dermatitis	3.9%
232	Eczema	3.9%
233	Erythema Multiforme	3.9%
234	Intertrigo	3.9%
235	Neurodermatitis	3.9%
236	Rhinophyma	3.9%
237	Perioral Dermatitis	3.9%
238	Acne	3.9%
239	Rubinstein-Taybi Syndrome	3.9%
240	Myotonic Dystrophy	3.9%
241	Muscular Dystrophy	3.9%
242	Orbital Myositis	3.9%
243	Pyomyositis	3.8%
244	Acromegaly	3.8%
245	Joint Tuberculosis	3.8%
246	Tuberculosis, Osteoarticular	3.8%
247	Bone Tuberculosis	3.8%
248	Dermatitis, Atopic	3.7%
249	Epidermolysis Bullosa	3.7%
250	Xeroderma Pigmentosum	3.6%
251	Retrognathia	3.6%
252	Skin Abnormalities	3.4%
253	Skin Diseases, Infectious	3.4%
254	Skin Neoplasms	3.4%
255	Pigmentation Disorders	3.4%
256	Dermatitis Herpetiformis	3.3%
257	Lipomatosis	3.3%
258	Pruritus	3.3%
259	Erythema	3.3%
260	Necrolytic Migratory Erythema	3.3%
261	Cutaneous Fistula	3.3%
262	Nephrogenic Fibrosing Dermopathy	3.3%
263	Nephrogenic Systemic Fibrosis	3.3%
264	Maxillofacial Abnormalities	3.3%
265	Acrodermatitis	3.3%
266	Sebaceous Gland Neoplasms	3.3%
267	Porokeratosis	3.3%
268	Gianotti-Crosti Syndrome	3.3%
269	Keratoderma, Palmoplantar	3.3%
270	Myotonia Congenita	3.3%
271	Rickets	3.3%
272	Basal Cell Nevus Syndrome	3.3%
273	Foot Ulcer	3.3%
274	Rheumatoid Nodule	3.3%
275	Microcephaly	3.2%
276	Macrocephaly	3.2%
277	Osteoporosis, Postmenopausal	3.2%
278	Dermatitis, Phototoxic	3.2%
279	Pityriasis Lichenoides et Varioliformis Acuta	3.2%
280	Pityriasis Lichenoides	3.2%
281	Phototoxicity	3.2%
282	Hypokalemic periodic paralysis	3.2%
283	Melorheostosis	3.2%
284	Osteopetrosis	3.2%
285	Spondylolisthesis	3.2%
286	Cleft Palate	3%
287	CREST Syndrome	2.9%
288	Pseudohypoparathyroidism	2.9%
289	Xeroderma	2.9%
290	Mitochondrial Encephalomyopathies	2.9%
291	Dermatitis, Photoallergic	2.8%
292	Mastocytosis	2.8%
293	Welander Distal Myopathy	2.7%
294	Urticaria Pigmentosa	2.7%
295	Mastoiditis	2.7%
296	Petrositis	2.7%
297	Dermatitis, Irritant	2.6%
298	Acne Conglobata	2.6%
299	Ectodermal Dysplasia	2.5%
300	Aplasia Cutis Congenita	2.5%
301	Anhidrosis	2.5%
302	Cholesteatoma	2.5%
303	Pressure Ulcer	2.5%
304	Folliculitis	2.5%
305	Foot Dermatoses	2.5%
306	Gynecomastia	2.5%
307	Hypertrichosis	2.5%
308	Hypohidrosis	2.5%
309	Hypotrichosis	2.5%
310	Leg Ulcer	2.5%
311	Miliaria	2.5%
312	Parakeratosis	2.5%
313	Parapsoriasis	2.5%
314	Pityriasis	2.5%
315	Psoriasis	2.5%
316	Sweet Syndrome	2.5%
317	Hidradenitis	2.5%
318	Onycholysis	2.5%
319	Miliaria Rubra	2.5%
320	Hyperpigmentation	2.5%
321	Lichenoid Eruptions	2.5%
322	Chloracne	2.5%
323	Mucopolysaccharidosis III	2.4%
324	Erythema Infectiosum	2.4%
325	Exanthema Subitum	2.4%
326	Muscular Dystrophy, Duchenne	2.3%
327	Erythema Nodosum	2.3%
328	Osteomalacia	2.3%
329	Porencephaly	2.3%
330	Holoprosencephaly	2.3%
331	Dermatitis, Occupational	2.2%
332	Dermatitis, Allergic Contact	2.2%
333	Toxic Epidermal Necrolysis	2.2%
334	Stevens-Johnson Syndrome	2.2%
335	Papillon-Lefevre Disease	2.2%
336	Lupus Vasculitis, Central Nervous System	2.1%
337	Tinea Capitis	2.1%
338	Onychomycosis	2.1%
339	Ecthyma	2%
340	Acantholysis	2%
341	Breast Cyst	2%
342	Actinic keratosis	2%
343	Pemphigoid, Benign Mucous Membrane	2%
344	Pemphigus	2%
345	Piedra	2%
346	Sunburn	2%
347	Argyria	2%
348	Hirsutism	2%
349	Lactation Disorder	2%
350	Mastitis	2%
351	Urticaria	2%
352	Adiposis Dolorosa	2%
353	Pruritus Vulvae	2%
354	Mastocytoma	2%
355	Pruritus Ani	2%
356	Diaper Rash	1.9%
357	Ichthyosis, X-Linked	1.9%
358	Sjogren-Larsson Syndrome	1.9%
359	Behcet Syndrome	1.8%
360	Cockayne Syndrome	1.8%
361	Hyperkeratosis, Epidermolytic	1.8%
362	Mucopolysaccharidosis II	1.8%
363	Nose Neoplasms	1.7%
364	Dermatomycoses	1.7%
365	Mucocutaneous Lymph Node Syndrome	1.7%
366	Skin Diseases, Bacterial	1.7%
367	Albinism	1.7%
368	Drug Eruptions	1.6%
369	Lipodystrophy	1.6%
370	Livedo Reticularis	1.6%
371	Malignant Atrophic Papulosis	1.6%
372	Hidradenitis Suppurativa	1.6%
373	Polyarteritis Nodosa	1.6%
374	Takayasu Arteritis	1.6%
375	Lichen Planus	1.6%
376	Melanosis	1.6%
377	Chloasma	1.6%
378	Pityriasis Rosea	1.6%
379	Pityriasis Rubra Pilaris	1.6%
380	Vitiligo	1.6%
381	Lichen Nitidus	1.6%
382	Erythema Chronicum Migrans	1.6%
383	Renal Osteodystrophy	1.6%
384	Renal rickets	1.6%
385	Radicular Cyst	1.6%
386	Porphyrias, Hepatic	1.4%
387	Tinea Pedis	1.4%
388	MELAS Syndrome	1.3%
389	Alopecia	1.3%
390	Sweating, Gustatory	1.3%
391	Androgenetic Alopecia	1.3%
392	Auriculotemporal Syndrome	1.3%
393	Lice Infestations	1.3%
394	Varicose Ulcer	1.3%
395	Breast Neoplasms, Male	1.3%
396	Triple Negative Breast Neoplasms	1.3%
397	Mycetoma	1.3%
398	Galactorrhea	1.3%
399	Kearns-Sayre syndrome	1.2%
400	Acanthosis Nigricans	1.2%
401	Alopecia Areata	1.2%
402	Lentigo	1.2%
403	Larva Migrans	1.1%
404	Leishmaniasis	1.1%
405	Molluscum Contagiosum	1.1%
406	Angioedema	1.1%
407	Onchocerciasis	1.1%
408	Chromoblastomycosis	1.1%
409	Dermatophytosis	1.1%
410	Sporotrichosis	1.1%
411	Tinea	1.1%
412	Tinea Versicolor	1.1%
413	Trichophytosis	1.1%
414	Hyalohyphomycosis	1.1%
415	Acute Generalized Exanthematous Pustulosis	1.1%
416	Lichen Planus, Oral	1%
417	Giant Cell Arteritis	1%
418	Temporal Arteritis	1%
419	Warts	1%
420	Candidiasis, Chronic Mucocutaneous	0.9%
421	Cutaneous Candidiasis	0.9%
422	Erysipelas	0.9%
423	Serum Sickness	0.9%
424	Staphylococcal Skin Infections	0.9%
425	Variegate Porphyria	0.9%
426	Acute intermittent porphyria	0.9%
427	Porphyria Cutanea Tarda	0.9%
428	Erythrasma	0.9%
429	Carcinoma, Lobular	0.9%
430	Familial Hypophosphatemic Rickets	0.8%
431	Leishmaniasis, Cutaneous	0.8%
432	Eczema Herpeticum	0.8%
433	Fusariosis	0.8%
434	Menkes Kinky Hair Syndrome	0.7%
435	Blastomycosis	0.7%
436	HIV-Associated Lipodystrophy Syndrome	0.7%
437	Angioedemas, Hereditary	0.7%
438	Epidermodysplasia Verruciformis	0.7%
439	Herpes Labialis	0.7%
440	Diabetic Foot	0.7%
441	Staphylococcal Scalded Skin Syndrome	0.7%
442	Hereditary Angioedema Type III	0.7%
443	Hereditary Angioedema Types I and II	0.7%
444	Rhinoscleroma	0.7%
445	Condylomata Acuminata	0.6%
446	Furunculosis	0.6%
447	furuncle	0.6%
448	Impetigo	0.6%
449	Peutz-Jeghers Syndrome	0.6%
450	carbuncle	0.6%

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