MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Stiff-Person Syndrome

(UMLS:C0085292)

Definition:: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
UMLS ID:: C0085292
MeSH ID:: D016750

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.114.812|C10.228.854.790|C10.668.900

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.258.850

Synonym(s)

Stiff-Person Syndrome

Gamma neuron overactivity syndrome

MUSCULAR RIGIDITY AND SPASM, PROGRESSIVE

Moersch-Woltman syndrome

Moersch-Woltmann syndrome

Progressive encephalomyelitis with rigidity

STIFF-PERSON SYNDROME

Stiff Person Syndrome

Stiff man syndrome

10.

Stiff person syndrome

11.

Stiff-man syndrome

12.

Subacute myoclonic spinal neuronitis

13.

mans stiff syndrome

14.

moersch woltman syndrome

15.

moersch-woltman syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Baclofen	12821743	CTD
2	Isotretinoin	12398844	CTD
3	Sufentanil	7618699	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Polyradiculoneuropathy	47.6%
2	Polyradiculoneuritis	47.6%
3	Myasthenia Gravis	46.1%
4	Guillain-Barre Syndrome	42.3%
5	Leukoencephalitis, Acute Hemorrhagic	41.3%
6	Spinal Muscular Atrophy	40.8%
7	Progressive Muscular Atrophy	40.8%
8	Myasthenia Gravis, Autoimmune, Experimental	40.3%
9	Amyotrophic Lateral Sclerosis	37.5%
10	Lambert-Eaton Myasthenic Syndrome	37.3%
11	Poliomyelitis	37.1%
12	Myelitis, Transverse	36.4%
13	Neuromyelitis Optica	36.4%
14	Myelitis	36.4%
15	Miller Fisher Syndrome	36.2%
16	Meningoencephalitis	36.1%
17	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	35.8%
18	Motor Neuron Disease	34.9%
19	Epidural Abscess	34.9%
20	Multiple System Atrophy	34.5%
21	Encephalomyelitis, Acute Disseminated	34.2%
22	Encephalomyelitis	33.3%
23	Lupus Vasculitis, Central Nervous System	32.6%
24	Uveomeningoencephalitic Syndrome	32.4%
25	Vasculitis, Central Nervous System	32.1%
26	Subacute Combined Degeneration	31.8%
27	Multiple Sclerosis	31.4%
28	Spinal Cord Injuries	31.3%
29	Neuritis, Autoimmune, Experimental	30.1%
30	Causalgia	29.8%
31	Complex Regional Pain Syndromes	28.7%
32	Lewy Body Disease	28.6%
33	Ocular Motility Disorders	28.6%
34	Cyclophoria	28.6%
35	Pneumocephalus	27.8%
36	Parkinson Disease	27.8%
37	Chronic Fatigue Syndrome	27.4%
38	Syringomyelia	27.4%
39	Pneumorrhachis	27.4%
40	Spinal Cord Neoplasms	27.1%
41	Striatonigral Degeneration	26.9%
42	Prion Diseases	26.4%
43	Neuromuscular Junction Diseases	26.4%
44	Peripheral Nervous System Diseases	26.4%
45	Ophthalmoplegic Migraine	26.1%
46	Brachial Plexus Neuritis	25.8%
47	Neuralgic Amyotrophy	25.8%
48	Progressive supranuclear palsy	25.7%
49	Multiple Sclerosis, Chronic Progressive	25.5%
50	Multiple Sclerosis, Relapsing-Remitting	25.5%
51	Dandy-Walker Syndrome	25.4%
52	Progressive bulbar palsy	25%
53	Bulbar palsy	25%
54	Peripheral Nerve Injuries	24.8%
55	Tarsal Tunnel Syndrome	24.4%
56	Cauda Equina Syndrome	24.4%
57	Subdural Effusion	24.3%
58	Parkinsonian Disorders	24.3%
59	Cranial nerve diseases	24.3%
60	Demyelinating Diseases	24.3%
61	Demyelination	24.3%
62	Chronobiology Disorders	24.3%
63	Restless Legs Syndrome	24%
64	Shy-Drager Syndrome	23.9%
65	Brain Diseases	23.6%
66	Meningitis	23.6%
67	Movement Disorders	23.6%
68	Pachymeningitis	23.6%
69	Marchiafava-Bignami Disease	23.4%
70	Leukoencephalopathy, Progressive Multifocal	23.1%
71	Conus Medullaris Syndrome	23%
72	Spinal Cord Vascular Diseases	23%
73	Central Cord Syndrome	22.9%
74	Dystonia Musculorum Deformans	22.7%
75	MPTP Poisoning	22.7%
76	Myopathy	22.6%
77	Asterixis	22.5%
78	Ballismus	22.5%
79	Friedreich Ataxia	22.4%
80	Reflex Sympathetic Dystrophy	22%
81	Autonomic Dysreflexia	21.8%
82	Dementia, Vascular	21.6%
83	Huntington Disease	21.4%
84	Meige Syndrome	21.3%
85	Cerebral Ventriculitis	21.3%
86	Botulism	21.3%
87	Epilepsy, Post-Traumatic	21.2%
88	Opsoclonus-Myoclonus Syndrome	21.2%
89	Carpal Tunnel Syndrome	20.9%
90	Meningitis, Bacterial	20.8%
91	Meningitis, Fungal	20.8%
92	Trauma, Nervous System	20.7%
93	Sciatica	20.7%
94	Brain Abscess	20.4%
95	Central Nervous System Infection	20.2%
96	Nervous System Neoplasms	20.2%
97	Neurologic Manifestations	20.2%
98	Neurotoxicity Syndromes	20.2%
99	Limbic Encephalitis	20.1%
100	Neuroleptic Malignant Syndrome	20%
101	Myelinolysis, Central Pontine	20%
102	Posterior Leukoencephalopathy Syndrome	19.9%
103	Posterior reversible encephalopathy syndrome	19.9%
104	Giant Cell Arteritis	19.8%
105	Temporal Arteritis	19.8%
106	Acrodynia	19.7%
107	Cubital Tunnel Syndrome	19.5%
108	Cerebellar Neoplasms	19.4%
109	Brain Injuries	19.4%
110	Dyskinesia, Drug-Induced	19.4%
111	Brain Neoplasms	19.3%
112	Neuritis	19.2%
113	Polyneuritis	19.2%
114	Radiculitis	19.2%
115	Polyneuropathy	19.2%
116	Mononeuritis	19.2%
117	Mononeuropathies	19.2%
118	Brachial Plexus Neuropathies	19.2%
119	Radiculopathy	19.2%
120	Mononeuropathy Multiplex	19.2%
121	Nerve Root Compression	19.2%
122	Tuberculosis, Meningeal	19.1%
123	Olfactory Nerve Injuries	18.9%
124	Lafora Disease	18.9%
125	Unverricht-Lundborg Syndrome	18.9%
126	Myoclonic Epilepsy	18.4%
127	Epilepsy, Temporal Lobe	18.4%
128	Epilepsy, Rolandic	18.4%
129	Benign Rolandic Epilepsy	18.4%
130	Charcot-Marie-Tooth Disease	18.3%
131	Creutzfeldt-Jakob disease	18.3%
132	Basal Ganglia Cerebrovascular Disease	18.3%
133	Myotonic Dystrophy	18.1%
134	Brain Hemorrhage, Traumatic	18%
135	Canavan Disease	17.5%
136	Alexander Disease	17.5%
137	Sleep Wake Disorders	17.5%
138	Spinal Cord Ischemia	17.5%
139	Akathisia, Drug-Induced	17.5%
140	Stiff-Person Syndrome	17.2%
141	Scrapie	17.1%
142	Vascular Headaches	17%
143	Juvenile Myoclonic Epilepsy	17%
144	Myoclonic Epilepsies, Progressive	17%
145	Hypoxia-Ischemia, Brain	16.9%
146	Presenile dementia	16.9%
147	Senile dementia	16.9%
148	Chorea	16.8%
149	Facial Nerve Injuries	16.8%
150	Brain Death	16.7%
151	Hepatolenticular Degeneration	16.7%
152	Ataxia Telangiectasia	16.7%
153	Sleep Disorders, Circadian Rhythm	16.7%
154	Myotonia Congenita	16.5%
155	Akinetic Mutism	16.4%
156	Anoxic Encephalopathy	16.4%
157	Arachnoiditis	16.4%
158	Basal Ganglia Diseases	16.4%
159	Brain Damage, Chronic	16.4%
160	Cerebellar Diseases	16.4%
161	Encephalitis	16.4%
162	Encephalomalacia	16.4%
163	Epilepsy	16.4%
164	Hydrocephalus	16.4%
165	Congenital Hydrocephalus	16.4%
166	Hypothalamic Diseases	16.4%
167	Aseptic Meningitis	16.4%
168	Thalamic Diseases	16.4%
169	Intracranial Hypertension	16.4%
170	Aura	16.4%
171	Leukoencephalopathy	16.4%
172	Essential Tremor	16.4%
173	Neuroaxonal Dystrophies	16.4%
174	Familial Tremor	16.4%
175	Headache Disorders	16.4%
176	Intracranial Hypotension	16.4%
177	Brain Edema	16.4%
178	Brain Hypoxia	16.4%
179	Aqueductal Stenosis	16.4%
180	Writer's Cramp	16.4%
181	Toxoplasmosis, Cerebral	16.4%
182	Nocturnal Myoclonus Syndrome	16.4%
183	Pituitary Adenoma	16.4%
184	Pituitary Neoplasms	16.4%
185	Carotid Artery Injuries	16.3%
186	Central Nervous System Cysts	16.2%
187	Myositis	16.1%
188	Isaacs syndrome	16.1%
189	Myotonic Disorders	16.1%
190	Myasthenic Syndromes, Congenital	16.1%
191	neurofibroma	16%
192	Leukomalacia, Periventricular	16%
193	Diabetic Neuropathies	15.9%
194	Diabetic Amyotrophy	15.9%
195	Diabetic Autonomic Neuropathy	15.9%
196	Basal Ganglia Hemorrhage	15.8%
197	Neuralgia	15.8%
198	Neuropathic pain	15.8%
199	Neuromuscular Diseases	15.7%
200	Sciatic Neuropathy	15.6%
201	Ulnar Neuropathies	15.6%
202	Lesion of Sciatic Nerve	15.6%
203	Ulnar Neuritis	15.6%
204	Radial nerve compression	15.6%
205	Radial Tunnel Syndrome	15.6%
206	Peroneal Neuropathies	15.6%
207	Radial Neuropathy	15.6%
208	Median Neuropathy	15.6%
209	Sciatic Nerve Palsy	15.6%
210	Femoral Neuropathy	15.6%
211	Tibial Neuropathy	15.6%
212	Ulnar Nerve Palsy	15.6%
213	Radial nerve palsy	15.6%
214	Amblyopia	15.6%
215	Mitochondrial Encephalomyopathies	15.6%
216	Brain Injuries, Diffuse	15.3%
217	Traumatic Brain Injury	15.3%
218	Dysautonomia	15.3%
219	Vagus Nerve Disorder	15.3%
220	Glossopharyngeal Neuralgia	15.3%
221	Abducens Nerve Diseases	15.3%
222	Heavy Metal Poisoning, Nervous System	15.3%
223	Tauopathies	15.3%
224	Trochlear Nerve Diseases	15.3%
225	Cerebellar Ataxia	15.3%
226	Supratentorial Neoplasms	15.3%
227	Torticollis	15.3%
228	Anterior Spinal Artery Syndrome	14.8%
229	Meningitis, Cryptococcal	14.8%
230	Horner Syndrome	14.8%
231	Meningitis, Listeria	14.8%
232	Meningitis, Haemophilus	14.7%
233	Meningitis, Pneumococcal	14.7%
234	Putaminal Hemorrhage	14.7%
235	Paraneoplastic Cerebellar Degeneration	14.7%
236	Subacute Sclerosing Panencephalitis	14.7%
237	Infarction, Middle Cerebral Artery	14.5%
238	Infarction, Anterior Cerebral Artery	14.5%
239	Infarction, Posterior Cerebral Artery	14.5%
240	Persistent Vegetative State	14.5%
241	Refsum Disease	14.4%
242	Hand-Arm Vibration Syndrome	14.1%
243	Tardive Dyskinesia	14%
244	Polyradiculopathy	13.9%
245	Pituitary Apoplexy	13.9%
246	Fibromyalgia	13.9%
247	Medial Tibial Stress Syndrome	13.9%
248	Brain Diseases, Metabolic	13.8%
249	Cerebrovascular Disorders	13.8%
250	Cerebrovascular Insufficiency	13.8%
251	Dementia	13.8%
252	Central Nervous System Fungal Infections	13.8%
253	Mitochondrial Myopathies	13.7%
254	Brain Infarction	13.7%
255	Eosinophilia-Myalgia Syndrome	13.7%
256	Alice in Wonderland Syndrome	13.6%
257	Ophthalmoplegia	13.6%
258	External Ophthalmoplegia	13.6%
259	Brain Concussion	13.6%
260	MELAS Syndrome	13.5%
261	Tuberous Sclerosis	13.4%
262	Diffuse Axonal Injury	13.3%
263	Brain Stem Neoplasms	13.3%
264	Jet Lag Syndrome	13.2%
265	Thoracic Outlet Syndrome	13.1%
266	Amnesia, Transient Global	13.1%
267	Optic Neuropathy	13.1%
268	Polymyositis	13%
269	Subarachnoid Hemorrhage, Traumatic	13%
270	Carotid Artery, Internal, Dissection	13%
271	Cerebral Palsy	12.9%
272	Epilepsies, Partial	12.9%
273	Epilepsy, Generalized	12.9%
274	Pseudotumor Cerebri	12.9%
275	Hypertensive Encephalopathy	12.9%
276	Simple Partial Seizures	12.9%
277	Epilepsy, Reflex	12.9%
278	Headache Disorders, Primary	12.9%
279	Headache Disorders, Secondary	12.9%
280	Medication overuse headache	12.9%
281	Coma, Post-Head Injury	12.9%
282	Facial Nerve Diseases	12.8%
283	Craniocerebral Trauma	12.8%
284	Parasomnia	12.8%
285	Dyssomnias	12.8%
286	Vestibulocochlear Nerve Diseases	12.6%
287	Decerebrate State	12.6%
288	Hemiparesis	12.6%
289	Hydranencephaly	12.6%
290	Meningism	12.6%
291	Neural Tube Defects	12.6%
292	Paresis	12.6%
293	Seizures	12.6%
294	Sensation Disorders	12.6%
295	Tethered Cord Syndrome	12.6%
296	Central Nervous System Neoplasms	12.6%
297	Complex partial seizures	12.6%
298	Iniencephaly	12.6%
299	Craniorachischisis	12.6%
300	Exencephaly	12.6%
301	Monoparesis	12.6%
302	Septo-Optic Dysplasia	12.6%
303	Cortical Dysplasia	12.6%
304	Neurogenic Inflammation	12.6%
305	Gait Disorders, Neurologic	12.6%
306	Neuromuscular Manifestations	12.6%
307	Malformations of Cortical Development	12.6%
308	Alstrom Syndrome	12.6%
309	Cerebral Infarction	12.6%
310	Brain Stem Infarctions	12.6%
311	Sweating, Gustatory	12.6%
312	Auriculotemporal Syndrome	12.6%
313	Antiphospholipid Syndrome	12.5%
314	West Nile Fever	12.4%
315	Adrenoleukodystrophy	12.3%
316	Choroid Plexus Papilloma	12.3%
317	Frontotemporal dementia	12.2%
318	Vocal Cord Paralysis	12.2%
319	Cerebrospinal Fluid Otorrhea	12.1%
320	Cerebrospinal Fluid Rhinorrhea	12.1%
321	Gait Ataxia	12.1%
322	Vertebral Artery Dissection	12.1%
323	Lateral Medullary Syndrome	12%
324	Central Nervous System Bacterial Infections	11.9%
325	Familial Periodic Paralysis	11.9%
326	Optic Nerve Glioma	11.8%
327	Amyloid Neuropathies, Familial	11.7%
328	Moyamoya Disease	11.7%
329	Brain Contusion	11.6%
330	POEMS Syndrome	11.3%
331	Neurofibrosarcoma	11.2%
332	Muscular Dystrophy	11.2%
333	Orbital Myositis	11.2%
334	Post-Traumatic Headache	11.2%
335	Tension Headache	11.2%
336	Epilepsy, Complex Partial	11.2%
337	Migraine Disorders	11.2%
338	Abdominal Migraine	11.2%
339	Status Migrainosus	11.2%
340	Cervicogenic Headache	11.2%
341	Pituitary Diseases	11.1%
342	Pupil Disorders	11.1%
343	Spinal Cord Diseases	11.1%
344	Neurobehavioral Manifestations	11.1%
345	Pyomyositis	11.1%
346	Paraneoplastic Encephalomyelitis	10.9%
347	Akathisia	10.8%
348	Restlessness	10.8%
349	Psychomotor Agitation	10.8%
350	Carotid Artery Diseases	10.7%
351	Brain Ischemia	10.7%
352	Cerebrovascular accident	10.7%
353	Kluver-Bucy Syndrome	10.7%
354	Vasospasm, Intracranial	10.7%
355	Intracranial Arterial Diseases	10.7%
356	Sturge-Weber Syndrome	10.7%
357	Vertigo	10.7%
358	Alcohol-Induced Disorders, Nervous System	10.7%
359	Alcohol Withdrawal Seizures	10.7%
360	Auditory Perceptual Disorders	10.6%
361	Tuberculosis, Central Nervous System	10.6%
362	Myalgia	10.5%
363	Lupus Erythematosus, Systemic	10.5%
364	Overlap syndrome	10.5%
365	Addison Disease	10.3%
366	Pemphigus	10.3%
367	Autoimmune thyroiditis	10.3%
368	Primary Adrenal Insufficiency	10.3%
369	Cluster Headache	10.3%
370	Migraine with Aura	10.3%
371	Familial Hemiplegic Migraine	10.3%
372	Chronic Paroxysmal Hemicrania	10.3%
373	SUNCT Syndrome	10.3%
374	Paroxysmal Hemicrania	10.3%
375	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.3%
376	Autoimmune hepatitis	10.3%
377	Kearns-Sayre syndrome	10.2%
378	Gait Apraxia	10.1%
379	Welander Distal Myopathy	9.8%
380	Hypokalemic periodic paralysis	9.6%
381	Voice Disorders	9.6%
382	Voice Disturbance	9.6%
383	Autoimmune Lymphoproliferative Syndrome	9.5%
384	Empty Sella Syndrome	9.4%
385	Hyperpituitarism	9.4%
386	Hypopituitarism	9.4%
387	Hypophysitis	9.4%
388	Smith-Magenis syndrome	9.4%
389	Dural Arteriovenous Fistula	9.4%
390	Hematoma, Subdural	9.3%
391	Hematoma, Epidural, Cranial	9.3%
392	Cerebral Arterial Diseases	9.2%
393	Vertebrobasilar Insufficiency	9.2%
394	Basilar Artery Stenosis	9.2%
395	Vertebral Artery Stenosis	9.2%
396	Intracranial Hemorrhage, Hypertensive	9.2%
397	Transient Cerebral Ischemia	9.2%
398	Optic Atrophy	9.2%
399	Optic Neuritis	9.2%
400	Papilledema	9.2%
401	Strabismus	9.2%
402	Tolosa-Hunt Syndrome	9.2%
403	Arsenic Poisoning	9.2%
404	Reye Syndrome	9.2%
405	Neuroaspergillosis	9.2%
406	Intracranial Embolism and Thrombosis	9.1%
407	Hepatic Encephalopathy	9.1%
408	Facial Injuries	9.1%
409	Facial Neuralgia	9.1%
410	Sleep Talking	9.1%
411	Manganese Poisoning	9.1%
412	Sleep Disorders, Intrinsic	9.1%
413	Orthostatic intolerance	9.1%
414	Anosmia	9%
415	Ataxia	9%
416	Athetosis	9%
417	Catalepsy	9%
418	Dystonia	9%
419	Hemiplegia	9%
420	Locked-In Syndrome	9%
421	Meningeal Neoplasms	9%
422	Meningomyelocele	9%
423	Muscle Hypertonia	9%
424	Muscle hypotonia	9%
425	Myoclonus	9%
426	Myotonia	9%
427	Paraplegia	9%
428	Pseudobulbar Palsy	9%
429	Quadriplegia	9%
430	Spasm	9%
431	Spastic Paraplegia	9%
432	Status Epilepticus	9%
433	Taste Disorders	9%
434	Tremor	9%
435	Spina Bifida	9%
436	Monoplegia	9%
437	Hypokinesia	9%
438	Paraparesis	9%
439	Bradykinesia	9%
440	Waxy flexibility	9%
441	Action Tremor	9%
442	Resting Tremor	9%
443	Dysosmia	9%
444	Quadriparesis	9%
445	Mercury Poisoning, Nervous System	9%
446	Olfaction Disorders	9%
447	Myokymia	9%
448	Lead Poisoning, Nervous System	9%
449	Vestibular Neuronitis	9%
450	Somatosensory Disorders	9%
451	Hyperkinesia	9%
452	Intention tremor	9%
453	Classical Lissencephalies and Subcortical Band Heterotopias	9%
454	Latent Autoimmune Diabetes in Adults	8.9%
455	Postural Orthostatic Tachycardia Syndrome	8.8%
456	Dermatitis Herpetiformis	8.8%
457	Dermatomyositis	8.7%
458	Muscular Dystrophy, Duchenne	8.6%
459	Hyperprolactinemia	8.6%
460	Hematoma, Subdural, Intracranial	8.5%
461	Hematoma, Subdural, Chronic	8.5%
462	Hematoma, Subdural, Acute	8.5%
463	AIDS Dementia Complex	8.5%
464	Subclavian Steal Syndrome	8.5%
465	Pick Disease of the Brain	8.5%
466	Kernicterus	8.5%
467	Alexia	8.4%
468	Dyslexia	8.4%
469	Pseudorabies	8.3%
470	Reflex, Abnormal	8.2%
471	Hyporeflexia	8.2%
472	Hyperreflexia	8.2%
473	Acoustic Neuroma	8.1%
474	Waterhouse-Friderichsen Syndrome	8%
475	Brain Diseases, Metabolic, Inborn	8%
476	Toxoplasmosis, Congenital	8%
477	Vision Disorders	8%
478	Metamorphopsia	8%
479	Visual Impairment	8%
480	Malaria, Cerebral	8%
481	Optic Neuropathy, Ischemic	7.9%
482	Anterior Ischemic Optic Neuropathy	7.9%
483	Neurosyphilis	7.9%
484	Carotid Stenosis	7.9%
485	Intracranial Aneurysm	7.9%
486	Neurocysticercosis	7.9%
487	Intracranial Arteriosclerosis	7.9%
488	Cerebral Atherosclerosis	7.9%
489	Subarachnoid Hemorrhage	7.9%
490	Cerebral Arteriosclerosis	7.9%
491	Cerebral Hemorrhage	7.9%
492	Cerebral Thrombosis	7.9%
493	Intracranial Embolism	7.9%
494	Intracranial Thrombosis	7.9%
495	Facial Hemiatrophy	7.8%
496	Melkersson-Rosenthal Syndrome	7.8%
497	Anisocoria	7.8%
498	Confusion	7.8%
499	Facial paralysis	7.8%
500	Lethargy	7.8%
501	Memory Disorders	7.8%
502	Muscle Cramp	7.8%
503	Perceptual Disorders	7.8%
504	Psychomotor Disorders	7.8%
505	Tonic Pupil	7.8%
506	Anhedonia	7.8%
507	Disorientation	7.8%
508	Facial Paresis	7.8%
509	Memory Loss	7.8%
510	Hemisensory Neglect	7.8%
511	Dysacusis	7.8%
512	Sleep Bruxism	7.8%
513	Rheumatoid Arthritis	7.8%
514	Juvenile arthritis	7.8%
515	Anencephaly	7.7%
516	Meningocele	7.7%
517	Muscular Atrophy	7.7%
518	Respiratory Paralysis	7.7%
519	Encephalocele	7.7%
520	Graves Disease	7.7%
521	Tetany	7.7%
522	Anti-Glomerular Basement Membrane Disease	7.6%
523	Optic Atrophy, Hereditary, Leber	7.4%
524	Esotropia	7.3%
525	Exotropia	7.3%
526	Hypotension, Orthostatic	7.3%
527	Sleep Apnea Syndromes	7.3%
528	Post-Exercise Hypotension	7.3%
529	Acromegaly	7.3%
530	Autoimmune thrombocytopenia	7.3%
531	Immune thrombocytopenic purpura	7.3%
532	Disorders of Excessive Somnolence	7.3%
533	Sleep Initiation and Maintenance Disorders	7.3%
534	Night Terrors	7.3%
535	Somnambulism	7.3%
536	Trigeminal Nerve Disorder	7.3%
537	Transient Insomnia	7.3%
538	Sleep Paralysis	7.3%
539	Chronic Insomnia	7.3%
540	REM Sleep Behavior Disorder	7.3%
541	Hypersomnia	7.3%
542	Dermal Sinus	7.3%
543	Dysgeusia	7.3%
544	Formication	7.3%
545	Hyperalgesia	7.3%
546	Hyperesthesia	7.3%
547	Hypesthesia	7.3%
548	Language Disorders	7.3%
549	Numbness	7.3%
550	Paresthesia	7.3%
551	Paraparesis, Spastic	7.3%
552	Spina Bifida Cystica	7.3%
553	Trismus	7.3%
554	Spina Bifida Occulta	7.3%
555	Epilepsia Partialis Continua	7.3%
556	Hypogeusia	7.3%
557	Meningeal Carcinomatosis	7.3%
558	Brown-Sequard Syndrome	7.3%
559	Lissencephaly	7.3%
560	Polymicrogyria	7.3%
561	Pachygyria	7.3%
562	Schizencephaly	7.3%
563	Lockjaw	7.3%
564	Allodynia	7.3%
565	Lead Poisoning, Nervous System, Childhood	7.3%
566	Lead Poisoning, Nervous System, Adult	7.3%
567	Periventricular Nodular Heterotopia	7.3%
568	Ageusia	7.3%
569	Cerebral Amyloid Angiopathy	7.3%
570	Sinus Thrombosis, Intracranial	7.2%
571	Hypersensitivity	7.1%
572	Immunologic Deficiency Syndromes	7.1%
573	Immunoproliferative Disorders	7.1%
574	Immune reconstitution syndrome	7.1%
575	Immune Reconstitution Inflammatory Syndrome	7.1%
576	Wernicke Encephalopathy	7.1%
577	Lyme Neuroborreliosis	7%
578	Cavernous Sinus Thrombosis	6.9%
579	Sagittal Sinus Thrombosis	6.9%
580	Duane Retraction Syndrome	6.9%
581	Consciousness Disorders	6.9%
582	Mental Retardation	6.9%
583	Muscle Weakness	6.9%
584	Depressed Level of Consciousness	6.9%
585	Mental deficiency	6.9%
586	Intellectual Disability	6.9%
587	Carotid Artery Thrombosis	6.8%
588	Mobius Syndrome	6.8%
589	Bell Palsy	6.8%
590	Catatonia	6.8%
591	Herpes Zoster Oticus	6.8%
592	Aphonia	6.8%
593	Sleep Deprivation	6.8%
594	Dysphonia	6.8%
595	Menkes Kinky Hair Syndrome	6.6%
596	Sleep Apnea, Obstructive	6.4%
597	Sleep Apnea, Central	6.4%
598	Eye Injuries	6.4%
599	Narcolepsy	6.4%
600	Trigeminal Neuralgia	6.4%
601	Kleine-Levin Syndrome	6.4%
602	Agraphia	6.4%
603	Anomia	6.4%
604	Cluttering	6.4%
605	Language Development Disorders	6.4%
606	Speech Disorders	6.4%
607	Syncope	6.4%
608	Stupor	6.4%
609	Dysgraphia	6.4%
610	Presyncope	6.4%
611	Dyslalia	6.4%
612	Congenital nystagmus	6.3%
613	Fabry Disease	6.3%
614	Diplopia	6.3%
615	Muscle Rigidity	6.3%
616	Muscle Spasticity	6.3%
617	Scotoma	6.3%
618	Photophobia	6.3%
619	Cogwheel Rigidity	6.3%
620	Hemifacial Spasm	6.3%
621	Amaurosis	6.3%
622	Blindness	6.3%
623	Nuchal Rigidity	6.3%
624	Agnosia	6.2%
625	Apraxias	6.2%
626	Hallucinations	6.2%
627	Hemianopsia	6.2%
628	Hyperacusis	6.2%
629	Tinnitus	6.2%
630	Visual Agnosia	6.2%
631	Anosognosia	6.2%
632	Wernicke-Korsakoff Syndrome	6.2%
633	Phonophobia	6.2%
634	Hearing Loss	6.2%
635	Sarcopenia	6.2%
636	Nelson Syndrome	6.1%
637	Cataplexy	6%
638	Aphasia	6%
639	Articulation Disorders	6%
640	Echolalia	6%
641	Stuttering	6%
642	Dysphasia	6%
643	Transfusion Reaction	6%
644	Hypotensive Transfusion Reaction	6%
645	Neuronal Ceroid-Lipofuscinoses	5.9%
646	Granulomatosis with polyangiitis	5.8%
647	Dysarthria	5.8%
648	Prolactinoma	5.7%
649	Growth Hormone-Secreting Pituitary Adenoma	5.7%
650	Eye Burns	5.6%
651	Amnesia	5.5%
652	Delirium	5.5%
653	Dissociative Amnesia	5.5%
654	Color blindness	5.5%
655	Global Amnesia	5.5%
656	Amaurosis Fugax	5.5%
657	Blindness, Cortical	5.5%
658	Dyscalculia	5.5%
659	Rett Syndrome	5.5%
660	Cri-du-Chat Syndrome	5.5%
661	Down Syndrome	5.5%
662	Trisomy 21	5.5%
663	Deafness	5.5%
664	Hearing Loss, Sudden	5.5%
665	Gerstmann Syndrome	5.5%
666	Hearing Loss, Bilateral	5.5%
667	Hearing Loss, High-Frequency	5.5%
668	Hearing Loss, Mixed Conductive-Sensorineural	5.5%
669	Prosopagnosia	5.5%
670	Apraxia, Ideomotor	5.5%
671	Charles Bonnet Syndrome	5.5%
672	Hearing Loss, Unilateral	5.5%
673	Complete Hearing Loss	5.5%
674	Alien Hand Syndrome	5.5%
675	Deaf Mutism	5.5%
676	Aicardi's syndrome	5.5%
677	Galactosemias	5.5%
678	Urea Cycle Disorders, Inborn	5.5%
679	Tyrosinemias	5.5%
680	Meningioma	5.5%
681	Williams Syndrome	5.5%
682	Microcephaly	5.4%
683	Macrocephaly	5.4%
684	Hoarseness	5.4%
685	Porencephaly	5.4%
686	Cockayne Syndrome	5.4%
687	Alcohol Withdrawal Delirium	5.4%
688	Mutism	5.2%
689	Selective Mutism	5.2%
690	Felty Syndrome	5%
691	Lupus Nephritis	5%
692	Homocystinuria	5%
693	Leigh Disease	4.9%
694	Alexia, Pure	4.9%
695	Glomerulonephritis, Membranoproliferative	4.9%
696	Corneal Scar	4.9%
697	Holoprosencephaly	4.9%
698	Prader-Willi Syndrome	4.9%
699	Phantom pain	4.8%
700	Phantom Limb Pain	4.8%
701	Retrograde amnesia	4.8%
702	Amnesia, Anterograde	4.8%
703	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.5%
704	Corneal Perforation	4.5%
705	Rheumatoid Vasculitis	4.5%
706	Fragile X Syndrome	4.2%
707	Immune Complex Diseases	4.2%
708	Latex allergy	4.2%
709	Glycogen storage disease type II	4.1%
710	Sicca Syndrome	4%
711	Sjogren's Syndrome	4%
712	Rubinstein-Taybi Syndrome	4%
713	Zellweger Syndrome	3.9%
714	Thrombocytopenic purpura	3.8%
715	Gaucher Disease	3.6%
716	Environmental Illness	3.6%
717	Tay-Sachs Disease	3.5%
718	Lymphoproliferative Disorders	3.5%
719	Paraproteinemias	3.4%
720	Lymphopenia	3.4%
721	Primary amyloidosis	3.4%
722	Monoclonal Gammopathy of Undetermined Significance	3.4%
723	Niemann-Pick Disease, Type C	3.3%
724	Mucopolysaccharidosis II	3.1%
725	Asthma, Aspirin-Induced	3%
726	Hypergammaglobulinemia	3%
727	Agammaglobulinemia	2.9%
728	Kounis Syndrome	2.9%
729	Serum Sickness	2.9%
730	HIV Infections	2.9%
731	Transfusion-Related Acute Lung Injury	2.9%
732	anaphylaxis	2.7%
733	Food Allergy	2.7%
734	Anaphylactic shock	2.7%
735	Multiple Myeloma	2.7%
736	Respiratory Hypersensitivity	2.4%
737	Sick Building Syndrome	2.3%
738	Multiple Chemical Sensitivity	2.3%
739	Plasmacytoma	2.3%
740	Tumor Lysis Syndrome	2.3%
741	Urticaria	2.3%
742	Vasculitis, Leukocytoclastic, Cutaneous	2.3%
743	HTLV-I Infections	2.3%
744	Job Syndrome	2.3%
745	Sezary Syndrome	2.3%
746	Milk Allergy	2%
747	Schnitzler Syndrome	2%
748	Wheat Hypersensitivity	2%
749	Lymphoma	2%
750	Mastocytosis	2%
751	Drug Eruptions	1.9%
752	Chronic granulomatous disease	1.9%
753	Heavy Chain Disease	1.9%
754	Dermatitis, Allergic Contact	1.9%
755	HIV Seropositivity	1.9%
756	Hydrops Fetalis	1.8%
757	Acquired Immunodeficiency Syndrome	1.7%
758	AIDS related complex	1.7%
759	Infectious Mononucleosis	1.7%
760	Cryoglobulinemia	1.7%
761	Mastocytosis, Systemic	1.7%
762	AIDS-Related Opportunistic Infections	1.5%
763	Dermatitis, Atopic	1.5%
764	HIV Wasting Syndrome	1.5%
765	AIDS-Associated Nephropathy	1.5%
766	Angioedema	1.5%
767	Hodgkin Disease	1.4%
768	Leukemia, Plasma Cell	1.4%
769	Lymphoma, Non-Hodgkin	1.4%
770	Leukemia, T-Cell	1.4%
771	Acute Generalized Exanthematous Pustulosis	1.4%
772	Leukemia, B-Cell	1.4%
773	Waldenstrom Macroglobulinemia	1.3%
774	Wiskott-Aldrich Syndrome	1.3%
775	HIV-Associated Lipodystrophy Syndrome	1.3%
776	Asthma	1.3%
777	Composite Lymphoma	1.3%
778	Erythema Nodosum	1.3%
779	Dermatitis, Photoallergic	1.3%
780	Lymphangioleiomyomatosis	1.3%
781	Asthma, Exercise-Induced	1.2%
782	Status Asthmaticus	1.2%
783	Lymphoma, Follicular	1.2%
784	T-Cell Lymphoma	1.2%
785	Mantle cell lymphoma	1.2%
786	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
787	Leukemia, Large Granular Lymphocytic	1.2%
788	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
789	Aspergillosis, Allergic Bronchopulmonary	1.1%
790	Asthma, Occupational	1.1%
791	Hereditary Angioedema Type III	1.1%
792	Hereditary Angioedema Types I and II	1.1%
793	Lymphoma, T-Cell, Cutaneous	1.1%
794	Lymphoma, AIDS-Related	1.1%
795	Enteropathy-Associated T-Cell Lymphoma	1.1%
796	Primary Effusion Lymphoma	1.1%
797	Farmer's Lung	1.1%
798	Angioedemas, Hereditary	1.1%
799	Hay fever	1%
800	Rhinitis, Allergic, Perennial	1%
801	Mycosis Fungoides	1%
802	Lymphomatoid Papulosis	1%
803	Plasmablastic lymphoma	1%
804	Toxic Epidermal Necrolysis	1%
805	Stevens-Johnson Syndrome	1%
806	Lymphomatoid Granulomatosis	0.9%
807	Burkitt Lymphoma	0.8%

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