MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tuberculosis, Central Nervous System

(UMLS:C0275904)

Definition:: Tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression. (From Adams et al., Principles of Neurology, 6th ed, pp717-20)
UMLS ID:: C0275904
MeSH ID:: D020306

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.040.552.846.570

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228.180.850

Synonym(s)

Tuberculosis, Central Nervous System

CNS TUBERCULOSIS

CNS tuberculosis

Tuberculosis of central nervous system

Tuberculosis of central nervous system, NOS

Unspecified tuberculosis of central nervous system, unspecified

central nervous system tuberculosis

cns tuberculosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Ethambutol	6709824	CTD
2	Isoniazid	6709824	CTD
3	Pyrazinamide	6709824	CTD
4	Rifampin	6709824	CTD
5	Streptomycin	6709824	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lymph Node Tuberculosis	33.3%
2	Tuberculosis, Miliary	33.3%
3	Tuberculosis, Multidrug-Resistant	33.3%
4	Latent Tuberculosis	33.3%
5	Encephalomyelitis	29.8%
6	Meningitis, Bacterial	29.8%
7	Meningoencephalitis	27.1%
8	Tuberculosis, Gastrointestinal	25.7%
9	Extensively Drug-Resistant Tuberculosis	25%
10	Leprosy	24.7%
11	Mycobacterium Infections, Nontuberculous	24.7%
12	Mycobacterium abscessus Infection	24.7%
13	Epidural Abscess	24.5%
14	Myelitis	24.4%
15	Neurosyphilis	22.1%
16	Meningitis, Listeria	21.9%
17	Joint Tuberculosis	21.8%
18	Tuberculosis, Osteoarticular	21.8%
19	Bone Tuberculosis	21.8%
20	Prion Diseases	21.5%
21	Tuberculosis, Pulmonary	20.9%
22	Central Nervous System Fungal Infections	20.9%
23	Actinomycosis	20%
24	Corynebacterium Infections	20%
25	Nocardia Infections	20%
26	Pulmonary Nocardiosis	20%
27	Meningitis, Pneumococcal	20%
28	Lyme Neuroborreliosis	19.9%
29	Brain Abscess	19.5%
30	Subdural Effusion	18.6%
31	Meningitis, Haemophilus	18.4%
32	Clostridium Infections	17%
33	Listeriosis	17%
34	Staphylococcal Infections	17%
35	Streptococcal Infections	17%
36	Bacillaceae Infections	17%
37	Clostridium difficile infection	17%
38	Brain Diseases	16.5%
39	Meningitis	16.5%
40	Movement Disorders	16.5%
41	Pachymeningitis	16.5%
42	Spinal Cord Diseases	16.5%
43	Meningitis, Fungal	16.4%
44	Mycobacterium avium-intracellulare Infection	16.4%
45	Leprosy, Multibacillary	16.4%
46	Cerebral Ventriculitis	16%
47	Tuberculosis, Meningeal	14.7%
48	Gram-Negative Bacterial Infections	14%
49	Ocular Motility Disorders	14%
50	Cyclophoria	14%
51	Poliomyelitis	13.6%
52	Erysipelothrix infection	13.5%
53	Tuberculosis, Spinal	13.3%
54	Creutzfeldt-Jakob disease	12.9%
55	Multiple System Atrophy	12.7%
56	Pneumocephalus	12.5%
57	Borderline leprosy	12.3%
58	Leprosy, Lepromatous	12.3%
59	Tuberculoid leprosy	12.3%
60	Parkinsonian Disorders	12.1%
61	Neuroaspergillosis	12%
62	Toxoplasmosis, Cerebral	12%
63	Diphtheria	11.9%
64	Central Nervous System Bacterial Infections	11.4%
65	Scrapie	11.2%
66	Tuberculosis, Renal	11.1%
67	Borrelia Infections	11%
68	Leptospirosis	11%
69	Leukoencephalopathy, Progressive Multifocal	10.8%
70	Meningitis, Cryptococcal	10.7%
71	Limbic Encephalitis	10.7%
72	Stiff-Person Syndrome	10.6%
73	Lupus Vasculitis, Central Nervous System	10.6%
74	Bacterial Vaginosis	10.4%
75	Cranial nerve diseases	10.4%
76	Demyelinating Diseases	10.4%
77	Demyelination	10.4%
78	Neuromuscular Diseases	10.4%
79	Chronobiology Disorders	10.4%
80	Erythrasma	10.3%
81	Parkinson Disease	10.1%
82	Erythema Induratum	10.1%
83	Lewy Body Disease	10%
84	Skin Diseases, Bacterial	10%
85	Bacteremia	9.9%
86	Spinal Muscular Atrophy	9.8%
87	Progressive Muscular Atrophy	9.8%
88	Akinetic Mutism	9.7%
89	Anoxic Encephalopathy	9.7%
90	Arachnoiditis	9.7%
91	Basal Ganglia Diseases	9.7%
92	Brain Damage, Chronic	9.7%
93	Cerebellar Diseases	9.7%
94	Encephalitis	9.7%
95	Encephalomalacia	9.7%
96	Epilepsy	9.7%
97	Hydrocephalus	9.7%
98	Congenital Hydrocephalus	9.7%
99	Hypothalamic Diseases	9.7%
100	Aseptic Meningitis	9.7%
101	Syringomyelia	9.7%
102	Thalamic Diseases	9.7%
103	Intracranial Hypertension	9.7%
104	Aura	9.7%
105	Leukoencephalopathy	9.7%
106	Essential Tremor	9.7%
107	Neuroaxonal Dystrophies	9.7%
108	Familial Tremor	9.7%
109	Headache Disorders	9.7%
110	Intracranial Hypotension	9.7%
111	Brain Edema	9.7%
112	Brain Hypoxia	9.7%
113	Aqueductal Stenosis	9.7%
114	Pneumorrhachis	9.7%
115	Writer's Cramp	9.7%
116	Spinal Cord Injuries	9.7%
117	Meige Syndrome	9.6%
118	Mycoses	9.5%
119	Infection	9.5%
120	Myelitis, Transverse	9.5%
121	Gas Gangrene	9.3%
122	Pneumococcal Infections	9.3%
123	Scarlet Fever	9.3%
124	Tetanus	9.3%
125	Dandy-Walker Syndrome	9.3%
126	Asterixis	9.3%
127	Ballismus	9.3%
128	Botulism	9.2%
129	Marchiafava-Bignami Disease	9%
130	Subacute Combined Degeneration	9%
131	Erysipelas	9%
132	Staphylococcal Skin Infections	9%
133	Subacute Sclerosing Panencephalitis	9%
134	Pneumonia, Bacterial	8.5%
135	Impetigo	8.4%
136	Amyotrophic Lateral Sclerosis	8.4%
137	Motor Neuron Disease	8.4%
138	Bacterial Endocarditis	8.4%
139	Posterior Leukoencephalopathy Syndrome	8.4%
140	Posterior reversible encephalopathy syndrome	8.4%
141	Striatonigral Degeneration	8.3%
142	Mycetoma	8.2%
143	Trauma, Nervous System	8.1%
144	Dystonia Musculorum Deformans	8.1%
145	Chronic Fatigue Syndrome	8.1%
146	Pseudorabies	8%
147	Progressive supranuclear palsy	7.9%
148	Waterhouse-Friderichsen Syndrome	7.9%
149	Brain Injuries	7.9%
150	Nervous System Neoplasms	7.8%
151	Neurologic Manifestations	7.8%
152	Neurotoxicity Syndromes	7.8%
153	Brain Neoplasms	7.8%
154	Spinal Cord Neoplasms	7.8%
155	Ecthyma	7.8%
156	Subacute Bacterial Endocarditis	7.8%
157	Basal Ganglia Cerebrovascular Disease	7.8%
158	Dementia, Vascular	7.8%
159	Epilepsy, Post-Traumatic	7.5%
160	Brain Diseases, Metabolic	7.5%
161	Cerebrovascular Disorders	7.5%
162	Cerebrovascular Insufficiency	7.5%
163	Dementia	7.5%
164	Conus Medullaris Syndrome	7.5%
165	Spinal Cord Vascular Diseases	7.5%
166	Bordetella Infections	7.3%
167	Brucellosis	7.3%
168	Campylobacter infection	7.3%
169	Enterobacteriaceae Infections	7.3%
170	Pseudomonas Infections	7.3%
171	Q Fever	7.3%
172	Vibrio Infections	7.3%
173	Helicobacter Infections	7.3%
174	Neisseriaceae Infections	7.3%
175	Burkholderia Infections	7.3%
176	Flavobacteriaceae Infections	7.3%
177	Moraxellaceae Infections	7.3%
178	Burkholderia cepacia Infection	7.3%
179	Neuroleptic Malignant Syndrome	7.2%
180	Myelinolysis, Central Pontine	7.2%
181	Lyme Disease	7.2%
182	Relapsing Fever	7.2%
183	MPTP Poisoning	7.2%
184	Central Nervous System Infection	7.2%
185	Shy-Drager Syndrome	7.2%
186	Myoclonic Epilepsy	7.2%
187	Epilepsy, Temporal Lobe	7.2%
188	Epilepsy, Rolandic	7.2%
189	Benign Rolandic Epilepsy	7.2%
190	Huntington Disease	7.1%
191	Toxoplasmosis, Congenital	6.9%
192	Malaria, Cerebral	6.8%
193	Vascular Headaches	6.8%
194	Neurocysticercosis	6.7%
195	West Nile Fever	6.7%
196	Hypoxia-Ischemia, Brain	6.7%
197	Restless Legs Syndrome	6.7%
198	Polyradiculoneuropathy	6.7%
199	Polyradiculoneuritis	6.7%
200	Akathisia, Drug-Induced	6.7%
201	Brain Death	6.6%
202	Autonomic Dysreflexia	6.6%
203	Complex Regional Pain Syndromes	6.6%
204	Leukomalacia, Periventricular	6.5%
205	Ophthalmoplegic Migraine	6.5%
206	Cerebral Palsy	6.4%
207	Epilepsies, Partial	6.4%
208	Epilepsy, Generalized	6.4%
209	Pseudotumor Cerebri	6.4%
210	Hypertensive Encephalopathy	6.4%
211	Simple Partial Seizures	6.4%
212	Epilepsy, Reflex	6.4%
213	Headache Disorders, Primary	6.4%
214	Headache Disorders, Secondary	6.4%
215	Medication overuse headache	6.4%
216	Sleep Wake Disorders	6.4%
217	Cerebellar Neoplasms	6.4%
218	Syphilis	6.2%
219	Opsoclonus-Myoclonus Syndrome	6.2%
220	Human Ehrlichiosis	6%
221	Amblyopia	6%
222	Juvenile Myoclonic Epilepsy	5.9%
223	Myoclonic Epilepsies, Progressive	5.9%
224	Central Cord Syndrome	5.9%
225	Leukoencephalitis, Acute Hemorrhagic	5.9%
226	Presenile dementia	5.9%
227	Senile dementia	5.9%
228	Chorea	5.8%
229	Dyskinesia, Drug-Induced	5.8%
230	Rheumatic Fever	5.8%
231	Friedreich Ataxia	5.8%
232	Encephalomyelitis, Acute Disseminated	5.7%
233	Hepatolenticular Degeneration	5.6%
234	Enterocolitis, Pseudomembranous	5.6%
235	pseudomembranous colitis	5.6%
236	Dysautonomia	5.5%
237	Vagus Nerve Disorder	5.5%
238	Glossopharyngeal Neuralgia	5.5%
239	Abducens Nerve Diseases	5.5%
240	Heavy Metal Poisoning, Nervous System	5.5%
241	Neuromuscular Junction Diseases	5.5%
242	Tauopathies	5.5%
243	Trochlear Nerve Diseases	5.5%
244	Peripheral Nervous System Diseases	5.5%
245	Chlamydia Infections	5.4%
246	Gonorrhea	5.4%
247	Peripheral Nerve Injuries	5.4%
248	Myasthenia Gravis	5.3%
249	Erythema Chronicum Migrans	5.3%
250	Miller Fisher Syndrome	5.3%
251	Lafora Disease	5.2%
252	Unverricht-Lundborg Syndrome	5.2%
253	Vasculitis, Central Nervous System	5.2%
254	Staphylococcal Scalded Skin Syndrome	5.2%
255	Brain Injuries, Diffuse	5.1%
256	Traumatic Brain Injury	5.1%
257	Cerebellar Ataxia	5.1%
258	Supratentorial Neoplasms	5.1%
259	Torticollis	5.1%
260	Pituitary Diseases	5.1%
261	Basal Ganglia Hemorrhage	5.1%
262	Human anaplasmosis	5%
263	Brain Hemorrhage, Traumatic	4.9%
264	Progressive bulbar palsy	4.9%
265	Bulbar palsy	4.9%
266	Guillain-Barre Syndrome	4.9%
267	Pituitary Apoplexy	4.9%
268	Paraneoplastic Cerebellar Degeneration	4.9%
269	Carotid Artery Diseases	4.8%
270	Brain Ischemia	4.8%
271	Cerebrovascular accident	4.8%
272	Kluver-Bucy Syndrome	4.8%
273	Vasospasm, Intracranial	4.8%
274	Spinal Cord Ischemia	4.8%
275	Intracranial Arterial Diseases	4.8%
276	Carotid Artery Injuries	4.8%
277	Amnesia, Transient Global	4.8%
278	Brain Infarction	4.8%
279	Japanese Spotted Fever	4.8%
280	Persistent Vegetative State	4.8%
281	Post-Traumatic Headache	4.8%
282	Tension Headache	4.8%
283	Epilepsy, Complex Partial	4.8%
284	Migraine Disorders	4.8%
285	Abdominal Migraine	4.8%
286	Status Migrainosus	4.8%
287	Cervicogenic Headache	4.8%
288	Hidradenitis Suppurativa	4.8%
289	Aspergillosis	4.7%
290	Candidiasis	4.7%
291	Coccidioidomycosis	4.7%
292	Histoplasmosis	4.7%
293	Paracoccidioidomycosis	4.7%
294	Pelvic Infection	4.7%
295	Wound Infection	4.7%
296	Zygomycosis	4.7%
297	Soft Tissue Infection	4.7%
298	Community-Acquired Infections	4.7%
299	Phaeohyphomycosis	4.7%
300	Pneumocystis Infections	4.7%
301	Canavan Disease	4.6%
302	Alexander Disease	4.6%
303	Sleep Disorders, Circadian Rhythm	4.6%
304	Pituitary Adenoma	4.6%
305	Pituitary Neoplasms	4.6%
306	Lambert-Eaton Myasthenic Syndrome	4.6%
307	Causalgia	4.5%
308	Furunculosis	4.5%
309	furuncle	4.5%
310	Hordeolum	4.4%
311	Central Nervous System Cysts	4.4%
312	Myopathy	4.4%
313	Optic Neuropathy	4.4%
314	Bacterial conjunctivitis	4.4%
315	Olfactory Nerve Injuries	4.3%
316	Dermatomycoses	4.3%
317	Putaminal Hemorrhage	4.3%
318	Rheumatic Heart Disease	4.3%
319	Ulcerative stomatitis	4.2%
320	Facial Nerve Diseases	4.2%
321	Craniocerebral Trauma	4.2%
322	Parasomnia	4.2%
323	Dyssomnias	4.2%
324	Tardive Dyskinesia	4.1%
325	Infarction, Middle Cerebral Artery	4.1%
326	Infarction, Anterior Cerebral Artery	4.1%
327	Infarction, Posterior Cerebral Artery	4.1%
328	Vestibulocochlear Nerve Diseases	4.1%
329	Decerebrate State	4.1%
330	Hemiparesis	4.1%
331	Hydranencephaly	4.1%
332	Meningism	4.1%
333	Neural Tube Defects	4.1%
334	Paresis	4.1%
335	Seizures	4.1%
336	Sensation Disorders	4.1%
337	Tethered Cord Syndrome	4.1%
338	Central Nervous System Neoplasms	4.1%
339	Complex partial seizures	4.1%
340	Iniencephaly	4.1%
341	Craniorachischisis	4.1%
342	Exencephaly	4.1%
343	Monoparesis	4.1%
344	Septo-Optic Dysplasia	4.1%
345	Cortical Dysplasia	4.1%
346	Neurogenic Inflammation	4.1%
347	Gait Disorders, Neurologic	4.1%
348	Neuromuscular Manifestations	4.1%
349	Malformations of Cortical Development	4.1%
350	Sweating, Gustatory	4.1%
351	Auriculotemporal Syndrome	4.1%
352	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4%
353	Reflex Sympathetic Dystrophy	4%
354	Nocturnal Myoclonus Syndrome	4%
355	Acinetobacter Infections	4%
356	Bacteroides Infections	4%
357	Cholera	4%
358	Escherichia coli Infections	4%
359	Haemophilus Infections	4%
360	Klebsiella Infections	4%
361	Meningococcal Infections	4%
362	Mycoplasma Infections	4%
363	Pasteurella Infections	4%
364	Proteus Infections	4%
365	Rickettsia Infections	4%
366	Salmonella infections	4%
367	Scrub Typhus	4%
368	Serratia Infections	4%
369	Ureaplasma Infections	4%
370	Cluster Headache	4%
371	Migraine with Aura	4%
372	Familial Hemiplegic Migraine	4%
373	Chronic Paroxysmal Hemicrania	4%
374	SUNCT Syndrome	4%
375	Paroxysmal Hemicrania	4%
376	Cerebral Infarction	4%
377	Brain Stem Infarctions	4%
378	Pertussis	4%
379	Multiple Sclerosis	3.9%
380	Reye Syndrome	3.9%
381	Neuromyelitis Optica	3.9%
382	Intracranial Embolism and Thrombosis	3.9%
383	Hepatic Encephalopathy	3.9%
384	Horner Syndrome	3.8%
385	Diffuse Axonal Injury	3.8%
386	Brain Stem Neoplasms	3.8%
387	Rhinoscleroma	3.8%
388	Moyamoya Disease	3.8%
389	Facial Nerve Injuries	3.7%
390	Mitochondrial Encephalomyopathies	3.7%
391	Eye Infection	3.7%
392	Respiratory Tract Infections	3.7%
393	Ataxia Telangiectasia	3.7%
394	Empty Sella Syndrome	3.7%
395	Hyperpituitarism	3.7%
396	Hypopituitarism	3.7%
397	Hypophysitis	3.7%
398	Cerebral Arterial Diseases	3.6%
399	Vertebrobasilar Insufficiency	3.6%
400	Anterior Spinal Artery Syndrome	3.6%
401	Basilar Artery Stenosis	3.6%
402	Vertebral Artery Stenosis	3.6%
403	Intracranial Hemorrhage, Hypertensive	3.6%
404	Transient Cerebral Ischemia	3.6%
405	Bone Diseases, Infectious	3.6%
406	Otomycosis	3.6%
407	Pregnancy Complications, Infectious	3.6%
408	Skin Diseases, Infectious	3.6%
409	Lateral Medullary Syndrome	3.6%
410	Arthritis, Infectious	3.5%
411	Piedra	3.5%
412	Suppuration	3.5%
413	Cross Infection	3.5%
414	Septicemia	3.5%
415	Sepsis	3.5%
416	Vertebral Artery Dissection	3.5%
417	Frontotemporal dementia	3.5%
418	Pupil Disorders	3.5%
419	Neurobehavioral Manifestations	3.5%
420	Subarachnoid Hemorrhage, Traumatic	3.4%
421	Carotid Artery, Internal, Dissection	3.4%
422	Paraneoplastic Encephalomyelitis	3.4%
423	Uveomeningoencephalitic Syndrome	3.3%
424	Ophthalmoplegia	3.3%
425	External Ophthalmoplegia	3.3%
426	carbuncle	3.3%
427	Sturge-Weber Syndrome	3.3%
428	Vertigo	3.3%
429	Alcohol-Induced Disorders, Nervous System	3.3%
430	Jet Lag Syndrome	3.3%
431	Brain Diseases, Metabolic, Inborn	3.3%
432	Myasthenia Gravis, Autoimmune, Experimental	3.2%
433	Auditory Perceptual Disorders	3.2%
434	Neuritis	3.2%
435	Polyneuritis	3.2%
436	Radiculitis	3.2%
437	Polyneuropathy	3.2%
438	Mononeuritis	3.2%
439	Mononeuropathies	3.2%
440	Brachial Plexus Neuropathies	3.2%
441	Radiculopathy	3.2%
442	Mononeuropathy Multiplex	3.2%
443	Nerve Root Compression	3.2%
444	Acrodynia	3.2%
445	Brain Concussion	3.2%
446	Brachial Plexus Neuritis	3.2%
447	Neuralgic Amyotrophy	3.2%
448	Brain Contusion	3.2%
449	Choroid Plexus Papilloma	3.2%
450	Candidiasis, Chronic Mucocutaneous	3.1%
451	Cutaneous Candidiasis	3.1%
452	Alice in Wonderland Syndrome	3.1%
453	Adrenoleukodystrophy	3.1%
454	Lymphogranuloma Venereum	3.1%
455	Opportunistic Infections	3.1%
456	Tuberous Sclerosis	3.1%
457	MELAS Syndrome	3.1%
458	Hyperprolactinemia	3%
459	Charcot-Marie-Tooth Disease	3%
460	Rocky Mountain Spotted Fever	3%
461	Subclavian Steal Syndrome	3%
462	Pick Disease of the Brain	3%
463	Syphilis, Congenital	2.9%
464	Fungemia	2.9%
465	Carotid Stenosis	2.9%
466	Intracranial Aneurysm	2.9%
467	Lung Diseases, Fungal	2.9%
468	Intracranial Arteriosclerosis	2.9%
469	Cerebral Atherosclerosis	2.9%
470	Subarachnoid Hemorrhage	2.9%
471	Cerebral Arteriosclerosis	2.9%
472	Cerebral Hemorrhage	2.9%
473	Cerebral Thrombosis	2.9%
474	Intracranial Embolism	2.9%
475	Intracranial Thrombosis	2.9%
476	Vocal Cord Paralysis	2.9%
477	Urinary tract infection	2.9%
478	Voice Disorders	2.8%
479	Voice Disturbance	2.8%
480	Tarsal Tunnel Syndrome	2.8%
481	Cauda Equina Syndrome	2.8%
482	Wernicke Encephalopathy	2.8%
483	AIDS Dementia Complex	2.8%
484	Smith-Magenis syndrome	2.8%
485	Pyomyositis	2.8%
486	Dural Arteriovenous Fistula	2.8%
487	Coma, Post-Head Injury	2.8%
488	Ophthalmia Neonatorum	2.7%
489	Trachoma	2.7%
490	Refsum Disease	2.7%
491	Myotonia Congenita	2.7%
492	Giant Cell Arteritis	2.7%
493	Temporal Arteritis	2.7%
494	Cerebrospinal Fluid Otorrhea	2.7%
495	Cerebrospinal Fluid Rhinorrhea	2.7%
496	Neuritis, Autoimmune, Experimental	2.7%
497	Gait Ataxia	2.7%
498	Multiple Sclerosis, Chronic Progressive	2.6%
499	Multiple Sclerosis, Relapsing-Remitting	2.6%
500	Myositis	2.5%
501	Optic Atrophy	2.5%
502	Optic Neuritis	2.5%
503	Papilledema	2.5%
504	Strabismus	2.5%
505	Tolosa-Hunt Syndrome	2.5%
506	Isaacs syndrome	2.5%
507	Arsenic Poisoning	2.5%
508	Myotonic Disorders	2.5%
509	Myasthenic Syndromes, Congenital	2.5%
510	Kernicterus	2.5%
511	Cellulitis	2.5%
512	Sexually Transmitted Diseases	2.5%
513	Diabetic Neuropathies	2.4%
514	Facial Injuries	2.4%
515	Facial Neuralgia	2.4%
516	Diabetic Amyotrophy	2.4%
517	Diabetic Autonomic Neuropathy	2.4%
518	Sleep Talking	2.4%
519	Manganese Poisoning	2.4%
520	Sleep Disorders, Intrinsic	2.4%
521	Orthostatic intolerance	2.4%
522	Alcohol Withdrawal Seizures	2.4%
523	Acromegaly	2.4%
524	Mucormycosis	2.4%
525	Anosmia	2.4%
526	Ataxia	2.4%
527	Athetosis	2.4%
528	Catalepsy	2.4%
529	Dystonia	2.4%
530	Hemiplegia	2.4%
531	Locked-In Syndrome	2.4%
532	Meningeal Neoplasms	2.4%
533	Meningomyelocele	2.4%
534	Muscle Hypertonia	2.4%
535	Muscle hypotonia	2.4%
536	Myoclonus	2.4%
537	Myotonia	2.4%
538	Neuralgia	2.4%
539	Paraplegia	2.4%
540	Pseudobulbar Palsy	2.4%
541	Quadriplegia	2.4%
542	Spasm	2.4%
543	Spastic Paraplegia	2.4%
544	Status Epilepticus	2.4%
545	Taste Disorders	2.4%
546	Tremor	2.4%
547	Spina Bifida	2.4%
548	Monoplegia	2.4%
549	Hypokinesia	2.4%
550	Paraparesis	2.4%
551	Bradykinesia	2.4%
552	Waxy flexibility	2.4%
553	Action Tremor	2.4%
554	Resting Tremor	2.4%
555	Dysosmia	2.4%
556	Quadriparesis	2.4%
557	Mercury Poisoning, Nervous System	2.4%
558	Olfaction Disorders	2.4%
559	Myokymia	2.4%
560	Lead Poisoning, Nervous System	2.4%
561	Vestibular Neuronitis	2.4%
562	Somatosensory Disorders	2.4%
563	Neuropathic pain	2.4%
564	Hyperkinesia	2.4%
565	Intention tremor	2.4%
566	Dysentery, Bacillary	2.4%
567	Carotid Artery Thrombosis	2.4%
568	Cerebral Amyloid Angiopathy	2.4%
569	Psittacosis	2.4%
570	Paratyphoid Fever	2.4%
571	Plague	2.4%
572	Typhoid Fever	2.4%
573	TYPHUS	2.4%
574	Yersinia pseudotuberculosis Infections	2.4%
575	Bubonic Plague	2.4%
576	Sinus Thrombosis, Intracranial	2.4%
577	Myotonic Dystrophy	2.4%
578	Blastomycosis	2.3%
579	Reflex, Abnormal	2.3%
580	Hyporeflexia	2.3%
581	Hyperreflexia	2.3%
582	Panophthalmitis	2.3%
583	Akathisia	2.3%
584	Restlessness	2.3%
585	Psychomotor Agitation	2.3%
586	Hematoma, Subdural	2.3%
587	Hematoma, Epidural, Cranial	2.3%
588	Candidemia	2.3%
589	Chromoblastomycosis	2.3%
590	Dermatophytosis	2.3%
591	Sporotrichosis	2.3%
592	Tinea	2.3%
593	Tinea Versicolor	2.3%
594	Trichophytosis	2.3%
595	Invasive Pulmonary Aspergillosis	2.3%
596	Hyalohyphomycosis	2.3%
597	Carpal Tunnel Syndrome	2.3%
598	Endotoxemia	2.3%
599	neurofibroma	2.2%
600	Sciatica	2.2%
601	Sciatic Neuropathy	2.1%
602	Ulnar Neuropathies	2.1%
603	Lesion of Sciatic Nerve	2.1%
604	Ulnar Neuritis	2.1%
605	Radial nerve compression	2.1%
606	Radial Tunnel Syndrome	2.1%
607	Peroneal Neuropathies	2.1%
608	Radial Neuropathy	2.1%
609	Median Neuropathy	2.1%
610	Sciatic Nerve Palsy	2.1%
611	Femoral Neuropathy	2.1%
612	Tibial Neuropathy	2.1%
613	Ulnar Nerve Palsy	2.1%
614	Postural Orthostatic Tachycardia Syndrome	2.1%
615	Radial nerve palsy	2.1%
616	Cavernous Sinus Thrombosis	2.1%
617	Sagittal Sinus Thrombosis	2.1%
618	Hand-Arm Vibration Syndrome	2.1%
619	Gait Apraxia	2.1%
620	Vision Disorders	2%
621	Metamorphopsia	2%
622	Visual Impairment	2%
623	Fibromyalgia	2%
624	Optic Neuropathy, Ischemic	2%
625	Anterior Ischemic Optic Neuropathy	2%
626	Medial Tibial Stress Syndrome	2%
627	Optic Nerve Glioma	2%
628	Facial Hemiatrophy	2%
629	Melkersson-Rosenthal Syndrome	2%
630	Mitochondrial Myopathies	2%
631	Anisocoria	2%
632	Confusion	2%
633	Facial paralysis	2%
634	Lethargy	2%
635	Memory Disorders	2%
636	Muscle Cramp	2%
637	Perceptual Disorders	2%
638	Psychomotor Disorders	2%
639	Tonic Pupil	2%
640	Eosinophilia-Myalgia Syndrome	2%
641	Anhedonia	2%
642	Disorientation	2%
643	Facial Paresis	2%
644	Memory Loss	2%
645	Hemisensory Neglect	2%
646	Dysacusis	2%
647	Sleep Bruxism	2%
648	Anencephaly	2%
649	Meningocele	2%
650	Muscular Atrophy	2%
651	Respiratory Paralysis	2%
652	Encephalocele	2%
653	Tetany	1.9%
654	Hematoma, Subdural, Intracranial	1.9%
655	Hematoma, Subdural, Chronic	1.9%
656	Hematoma, Subdural, Acute	1.9%
657	Alstrom Syndrome	1.9%
658	Cubital Tunnel Syndrome	1.9%
659	Salmonella Infections, Animal	1.9%
660	Oral candidiasis	1.9%
661	Endophthalmitis	1.9%
662	Peritonitis	1.9%
663	Osteomyelitis	1.8%
664	Periostitis	1.8%
665	Surgical Wound Infection	1.8%
666	Pulmonary Aspergillosis	1.8%
667	Bronchopulmonary Aspergillosis	1.8%
668	Abscess	1.8%
669	Adnexitis	1.8%
670	Empyema	1.8%
671	Pelvic Inflammatory Disease	1.8%
672	Salmonella food poisoning	1.8%
673	Galactosemias	1.8%
674	Urea Cycle Disorders, Inborn	1.8%
675	Tyrosinemias	1.8%
676	Nelson Syndrome	1.8%
677	Amyloid Neuropathies, Familial	1.8%
678	Fabry Disease	1.8%
679	Acoustic Neuroma	1.8%
680	Prolactinoma	1.7%
681	Growth Hormone-Secreting Pituitary Adenoma	1.7%
682	Duane Retraction Syndrome	1.7%
683	Consciousness Disorders	1.7%
684	Mental Retardation	1.7%
685	Muscle Weakness	1.7%
686	Depressed Level of Consciousness	1.7%
687	Mental deficiency	1.7%
688	Intellectual Disability	1.7%
689	Mobius Syndrome	1.7%
690	Bell Palsy	1.7%
691	Catatonia	1.7%
692	Herpes Zoster Oticus	1.6%
693	Thoracic Outlet Syndrome	1.6%
694	Familial Periodic Paralysis	1.6%
695	Aphonia	1.6%
696	Sleep Deprivation	1.6%
697	Dysphonia	1.6%
698	Homocystinuria	1.6%
699	Esotropia	1.6%
700	Exotropia	1.6%
701	Hypotension, Orthostatic	1.6%
702	Sleep Apnea Syndromes	1.6%
703	Polymyositis	1.6%
704	Post-Exercise Hypotension	1.6%
705	Menkes Kinky Hair Syndrome	1.6%
706	Leigh Disease	1.6%
707	Disorders of Excessive Somnolence	1.6%
708	Sleep Initiation and Maintenance Disorders	1.6%
709	Night Terrors	1.6%
710	Somnambulism	1.6%
711	Trigeminal Nerve Disorder	1.6%
712	Transient Insomnia	1.6%
713	Sleep Paralysis	1.6%
714	Chronic Insomnia	1.6%
715	REM Sleep Behavior Disorder	1.6%
716	Hypersomnia	1.6%
717	Dermal Sinus	1.6%
718	Dysgeusia	1.6%
719	Formication	1.6%
720	Hyperalgesia	1.6%
721	Hyperesthesia	1.6%
722	Hypesthesia	1.6%
723	Language Disorders	1.6%
724	Numbness	1.6%
725	Paresthesia	1.6%
726	Paraparesis, Spastic	1.6%
727	Spina Bifida Cystica	1.6%
728	Trismus	1.6%
729	Spina Bifida Occulta	1.6%
730	Epilepsia Partialis Continua	1.6%
731	Hypogeusia	1.6%
732	Meningeal Carcinomatosis	1.6%
733	Brown-Sequard Syndrome	1.6%
734	Lissencephaly	1.6%
735	Polymicrogyria	1.6%
736	Pachygyria	1.6%
737	Schizencephaly	1.6%
738	Lockjaw	1.6%
739	Allodynia	1.6%
740	Lead Poisoning, Nervous System, Childhood	1.6%
741	Lead Poisoning, Nervous System, Adult	1.6%
742	Periventricular Nodular Heterotopia	1.6%
743	Ageusia	1.6%
744	Classical Lissencephalies and Subcortical Band Heterotopias	1.6%
745	Polyradiculopathy	1.6%
746	Superinfection	1.5%
747	Corneal Ulcer	1.5%
748	Puerperal Infection	1.5%
749	Spondylitis	1.5%
750	Appendicitis	1.5%
751	Bacteriuria	1.5%
752	Pyuria	1.5%
753	Endotoxic shock	1.4%
754	Septic Shock	1.4%
755	Toxic Shock Syndrome	1.4%
756	Candidiasis, Vulvovaginal	1.4%
757	Myalgia	1.4%
758	Neuronal Ceroid-Lipofuscinoses	1.4%
759	Alexia	1.4%
760	Dyslexia	1.4%
761	Eye Injuries	1.3%
762	Psoas Abscess	1.3%
763	Abdominal Abscess	1.3%
764	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.3%
765	Muscular Dystrophy	1.3%
766	Congenital nystagmus	1.3%
767	Orbital Myositis	1.3%
768	Diplopia	1.3%
769	Muscle Rigidity	1.3%
770	Muscle Spasticity	1.3%
771	Scotoma	1.3%
772	Photophobia	1.3%
773	Cogwheel Rigidity	1.3%
774	Hemifacial Spasm	1.3%
775	Amaurosis	1.3%
776	Blindness	1.3%
777	Nuchal Rigidity	1.3%
778	Agnosia	1.3%
779	Apraxias	1.3%
780	Hallucinations	1.3%
781	Hemianopsia	1.3%
782	Hyperacusis	1.3%
783	Tinnitus	1.3%
784	Visual Agnosia	1.3%
785	Anosognosia	1.3%
786	Wernicke-Korsakoff Syndrome	1.3%
787	Phonophobia	1.3%
788	Hearing Loss	1.3%
789	Sarcopenia	1.3%
790	Fusariosis	1.3%
791	Optic Atrophy, Hereditary, Leber	1.3%
792	Aicardi's syndrome	1.3%
793	Neurofibrosarcoma	1.2%
794	Hoarseness	1.2%
795	Cockayne Syndrome	1.2%
796	Alcohol Withdrawal Delirium	1.2%
797	Zellweger Syndrome	1.2%
798	Kearns-Sayre syndrome	1.2%
799	Arthritis, Reactive	1.2%
800	Sleep Apnea, Obstructive	1.2%
801	Sleep Apnea, Central	1.2%
802	Narcolepsy	1.2%
803	Trigeminal Neuralgia	1.2%
804	Kleine-Levin Syndrome	1.2%
805	Agraphia	1.2%
806	Anomia	1.2%
807	Cluttering	1.2%
808	Glycogen storage disease type II	1.2%
809	Language Development Disorders	1.2%
810	Speech Disorders	1.2%
811	Syncope	1.2%
812	Stupor	1.2%
813	Dysgraphia	1.2%
814	Presyncope	1.2%
815	Dyslalia	1.2%
816	Holoprosencephaly	1.1%
817	Amnesia	1.1%
818	Delirium	1.1%
819	Dissociative Amnesia	1.1%
820	Color blindness	1.1%
821	Global Amnesia	1.1%
822	Cri-du-Chat Syndrome	1.1%
823	Down Syndrome	1.1%
824	Trisomy 21	1.1%
825	POEMS Syndrome	1.1%
826	Meningioma	1.1%
827	Williams Syndrome	1.1%
828	Microcephaly	1.1%
829	Macrocephaly	1.1%
830	Tinea Capitis	1.1%
831	Onychomycosis	1.1%
832	Hypokalemic periodic paralysis	1.1%
833	AIDS-Related Opportunistic Infections	1.1%
834	Porencephaly	1.1%
835	Diverticulitis	1%
836	Cataplexy	1%
837	Aphasia	1%
838	Articulation Disorders	1%
839	Echolalia	1%
840	Stuttering	1%
841	Dysphasia	1%
842	Eye Burns	1%
843	Gaucher Disease	1%
844	Welander Distal Myopathy	1%
845	Amaurosis Fugax	1%
846	Blindness, Cortical	1%
847	Dyscalculia	1%
848	Rett Syndrome	1%
849	Deafness	1%
850	Hearing Loss, Sudden	1%
851	Gerstmann Syndrome	1%
852	Hearing Loss, Bilateral	1%
853	Hearing Loss, High-Frequency	1%
854	Hearing Loss, Mixed Conductive-Sensorineural	1%
855	Prosopagnosia	1%
856	Apraxia, Ideomotor	1%
857	Charles Bonnet Syndrome	1%
858	Hearing Loss, Unilateral	1%
859	Complete Hearing Loss	1%
860	Alien Hand Syndrome	1%
861	Deaf Mutism	1%
862	Prader-Willi Syndrome	0.9%
863	Phantom pain	0.9%
864	Phantom Limb Pain	0.9%
865	Lemierre Syndrome	0.9%
866	Tinea Pedis	0.9%
867	Dysarthria	0.9%
868	Tay-Sachs Disease	0.9%
869	Niemann-Pick Disease, Type C	0.8%
870	Lung Abscess	0.8%
871	Dermatomyositis	0.8%
872	Corneal Scar	0.8%
873	Diverticulum	0.8%
874	Diverticulosis	0.8%
875	Muscular Dystrophy, Duchenne	0.8%
876	Mutism	0.8%
877	Selective Mutism	0.8%
878	Discitis	0.8%
879	Mastoiditis	0.8%
880	Petrositis	0.8%
881	Retrograde amnesia	0.8%
882	Amnesia, Anterograde	0.8%
883	Rubinstein-Taybi Syndrome	0.7%
884	Alexia, Pure	0.7%
885	Fragile X Syndrome	0.7%
886	Retropharyngeal Abscess	0.7%
887	Corneal Perforation	0.7%
888	Peritonsillar Abscess	0.7%
889	Liver Abscess	0.6%
890	Aspergillosis, Allergic Bronchopulmonary	0.6%
891	Mucopolysaccharidosis II	0.5%
892	Liver Abscess, Amebic	0.2%

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