MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acute Chest Syndrome

(UMLS:C0742343)

Definition:: Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.
UMLS ID:: C0742343
MeSH ID:: D056586

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.074|C08.618.009

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.150.150.219|C15.378.420.155.219

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.070.150.219|C16.320.365.155.219

Synonym(s)

Acute Chest Syndrome

Acute chest syndrome

Acute chest syndrome in sickle cell disease

CHEST SYNDROME ACUTE

acute chest syndrome

acute chest syndrome in conditions classified elsewhere

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Morphine	FAERS: 74	15001964	CTD US FAERS
2	Deferasirox	FAERS: 31		US FAERS
3	NuvaRing	FAERS: 5		US FAERS
4	rofecoxib	FAERS: 4		US FAERS
5	Ceftriaxone	FAERS: 2		US FAERS
6	Fentanyl	FAERS: 2		US FAERS
7	Meperidine	FAERS: 2		US FAERS
8	ambrisentan	FAERS: 2		US FAERS
9	Hydromorphone	FAERS: 1		US FAERS
10	Hydroxyurea	FAERS: 1		OFFSIDES US FAERS
11	Methadone	FAERS: 1		US FAERS
12	Prednisone	FAERS: 1		US FAERS
13	Sildenafil Citrate	FAERS: 1		US FAERS
14	Tadalafil	FAERS: 1		US FAERS
15	macitentan	FAERS: 1		US FAERS
16	treprostinil	FAERS: 1		US FAERS
17	Ketorolac			OFFSIDES
18	Naloxone			OFFSIDES
19	Nevirapine			OFFSIDES
20	Nitric Oxide			OFFSIDES
21	Stavudine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Sickle Cell Trait	46.2%
2	Thalassemia	38.2%
3	Respiratory Distress Syndrome, Adult	27%
4	Respiratory Distress Syndrome, Newborn	26.2%
5	Cystic Fibrosis	24.6%
6	Meconium Aspiration Syndrome	23.4%
7	Bronchitis, Chronic	21.1%
8	Bronchitis	21%
9	Pneumonia	20.3%
10	Lobar Pneumonia	20.3%
11	Pneumonitis	20.3%
12	Pleuropneumonia	20%
13	Thrombasthenia	19.6%
14	Antithrombin III Deficiency	19.6%
15	Protein C Deficiency	19.6%
16	Bronchopneumonia	19.3%
17	Pelger-Huet Anomaly	19.2%
18	Hyaline Membrane Disease	19.1%
19	Kartagener Syndrome	18.9%
20	Asthma	18.8%
21	Wiskott-Aldrich Syndrome	18.8%
22	Tracheobronchomegaly	18.3%
23	Idiopathic Pulmonary Fibrosis	18.2%
24	Lung Diseases, Fungal	18.1%
25	Pneumoconiosis	18.1%
26	Vocal Cord Dysfunction	18.1%
27	Lung Abscess	17.9%
28	Lung Neoplasms	17.9%
29	Tuberculosis, Pulmonary	17.9%
30	Afibrinogenemia	17.6%
31	Factor VII Deficiency	17.6%
32	Factor X Deficiency	17.6%
33	Factor XII Deficiency	17.6%
34	Hemophilia A	17.6%
35	Activated Protein C Resistance	17.6%
36	Factor II deficiency	17.6%
37	Factor VIII Deficiency	17.6%
38	Factor V deficiency	17.6%
39	Factor XI Deficiency	17.6%
40	Hypoprothrombinemias	17.6%
41	Disseminated Intravascular Coagulation	17.5%
42	Protein S Deficiency	17.5%
43	Granuloma, Laryngeal	17.2%
44	Scimitar Syndrome	16.3%
45	Bronchiolitis	16.2%
46	Anemia, Diamond-Blackfan	16.2%
47	Pulmonary Eosinophilia	16.1%
48	Eosinophilic Pneumonia	16.1%
49	Radiation Pneumonitis	16%
50	Radiation Fibrosis	16%
51	Primary Ciliary Dyskinesia	15.9%
52	Thrombocythemia, Essential	15.8%
53	Altitude Sickness	15.3%
54	Atelectasis	15.3%
55	Pulmonary Hypertension	15.3%
56	Pulmonary Alveolar Proteinosis	15.3%
57	Pulmonary Edema	15.3%
58	Pulmonary Fibrosis	15.3%
59	Respiratory Insufficiency	15.3%
60	Hamman-Rich syndrome	15.3%
61	Lung Diseases, Interstitial	15.3%
62	Respiratory Depression	15.3%
63	Lung Diseases, Obstructive	15.3%
64	Respiratory Failure	15.3%
65	Aspiration Pneumonia	15%
66	Asbestosis	14.8%
67	Berylliosis	14.8%
68	Silicosis	14.8%
69	Anemia, Neonatal	14.6%
70	Aspergillosis, Allergic Bronchopulmonary	14.5%
71	Persistent Fetal Circulation Syndrome	14.2%
72	Hemoglobinuria, Paroxysmal	14.2%
73	Aicardi's syndrome	14%
74	Pneumonia, Viral	13.6%
75	Pleurisy	13.5%
76	Tracheitis	13.5%
77	Lung Injury	13.5%
78	Hepatopulmonary Syndrome	13.5%
79	Respiratory Aspiration	13.5%
80	Apnea	13.4%
81	Cheyne-Stokes Respiration	13.4%
82	Dyspnea	13.4%
83	Hyperventilation	13.4%
84	Mouth Breathing	13.4%
85	Tachypnea	13.4%
86	Pneumonia, Bacterial	13.4%
87	CHARGE Syndrome	13.4%
88	Pulmonary Embolism	13.3%
89	Laryngospasm	13.3%
90	Blood Coagulation Disorders	13.3%
91	Blood Platelet Disorders	13.3%
92	Bone Marrow Diseases	13.3%
93	Hemorrhagic Disorders	13.3%
94	Leukocyte Disorders	13.3%
95	Methemoglobinemia	13.3%
96	Pancytopenia	13.3%
97	Polycythemia	13.3%
98	Sulfhemoglobinemia	13.3%
99	Thrombophilia	13.3%
100	Erythrocytosis	13.3%
101	Transfusion-Related Acute Lung Injury	13.3%
102	Multiple Pulmonary Nodules	13.2%
103	Choanal Atresia	12.9%
104	Laryngocele	12.9%
105	Neoplastic Syndromes, Hereditary	12.9%
106	Ichthyosis, X-Linked	12.7%
107	Hydrops Fetalis	12.6%
108	Multiple Epiphyseal Dysplasia	12.6%
109	Osteochondrodysplasias	12.6%
110	Werner Syndrome	12.6%
111	Myasthenic Syndromes, Congenital	12.6%
112	Pneumonia, Lipid	12.4%
113	Albinism	12.3%
114	Hoarseness	12.2%
115	Histiocytosis, Langerhans-Cell	12.1%
116	Nail-Patella Syndrome	12.1%
117	Laryngitis	12.1%
118	Rhinitis	12.1%
119	Bronchial Fistula	12%
120	Pleural Neoplasms	12%
121	Transfusion Reaction	11.9%
122	Hypotensive Transfusion Reaction	11.9%
123	Pleural Effusion, Malignant	11.9%
124	Hemoptysis	11.9%
125	Fragile X Syndrome	11.9%
126	Autoimmune Lymphoproliferative Syndrome	11.9%
127	Muscular Dystrophy, Duchenne	11.9%
128	Anemia, Macrocytic	11.7%
129	Bronchial Diseases	11.7%
130	Pleural Diseases	11.7%
131	Thoracic Diseases	11.7%
132	Tracheal Diseases	11.7%
133	Pregnancy Complications, Hematologic	11.7%
134	Hematologic Neoplasms	11.7%
135	Bone Marrow Neoplasms	11.6%
136	Cockayne Syndrome	11.6%
137	Vitamin K Deficiency	11.6%
138	Bronchiolitis Obliterans	11.5%
139	Dwarfism	11.4%
140	Airway Obstruction	11.4%
141	Choking	11.4%
142	Chronic Obstructive Airway Disease	11.4%
143	Middle Lobe Syndrome	11.4%
144	Acute Lung Injury	11.4%
145	Fanconi Anemia	11.4%
146	Sarcoidosis, Pulmonary	11.3%
147	Muscular Dystrophy	11.1%
148	Osteogenesis Imperfecta	11.1%
149	Beckwith-Wiedemann Syndrome	11.1%
150	Wolf-Hirschhorn Syndrome	11.1%
151	Alstrom Syndrome	10.9%
152	Bronchopulmonary Dysplasia	10.8%
153	Tracheal Neoplasms	10.7%
154	Farmer's Lung	10.6%
155	Thrombocytosis	10.5%
156	Laryngeal Diseases	10.5%
157	Nose Diseases	10.5%
158	Sinusitis	10.4%
159	Bronchial Neoplasms	10.4%
160	Marfan Syndrome	10.3%
161	Respiratory Tract Infections	10.3%
162	Hemolytic-Uremic Syndrome	10.3%
163	Granuloma, Respiratory Tract	10.2%
164	Respiratory Hypersensitivity	10.2%
165	Respiratory Tract Fistula	10.2%
166	Chronic granulomatous disease	10.2%
167	Smith-Magenis syndrome	10%
168	Pulmonary Aspergillosis	10%
169	Bronchopulmonary Aspergillosis	10%
170	Hypoventilation	10%
171	Eosinophilic Granuloma	9.9%
172	Cri-du-Chat Syndrome	9.9%
173	Down Syndrome	9.9%
174	Angioedemas, Hereditary	9.9%
175	Trisomy 21	9.9%
176	Acidosis, Respiratory	9.9%
177	Alkalosis, Respiratory	9.9%
178	Sleep Apnea Syndromes	9.9%
179	Blastomycosis	9.9%
180	Pulmonary Infarction	9.9%
181	Laryngeal neoplasm	9.9%
182	Acute Chest Syndrome	9.8%
183	Menkes Kinky Hair Syndrome	9.8%
184	Mucopolysaccharidosis II	9.7%
185	Anemia, Sickle Cell	9.7%
186	Holoprosencephaly	9.7%
187	Polycythemia Vera	9.6%
188	Pulmonary Emphysema	9.4%
189	Paranasal Sinus Neoplasms	9.2%
190	Myotonic Dystrophy	9.1%
191	Kallmann Syndrome	9.1%
192	Ectodermal Dysplasia	9.1%
193	Aplasia Cutis Congenita	9.1%
194	Prader-Willi Syndrome	9%
195	Dyspnea, Paroxysmal	8.8%
196	Respiratory Paralysis	8.8%
197	Asthma, Exercise-Induced	8.8%
198	Status Asthmaticus	8.8%
199	Granulomatosis with polyangiitis	8.8%
200	Deformity	8.8%
201	Tuberous Sclerosis	8.8%
202	Rett Syndrome	8.8%
203	Pseudoxanthoma Elasticum	8.7%
204	Rubinstein-Taybi Syndrome	8.6%
205	Familial Mediterranean Fever	8.5%
206	Lymphatic Diseases	8.4%
207	Adrenoleukodystrophy	8.4%
208	Nose Neoplasms	8.3%
209	Laryngostenosis	8.2%
210	Rhinoscleroma	8.2%
211	Purpura, Thrombotic Thrombocytopenic	8.2%
212	Sleep Apnea, Obstructive	8.2%
213	Sleep Apnea, Central	8.2%
214	Smith-Lemli-Opitz Syndrome	8.2%
215	Hepatolenticular Degeneration	8.1%
216	Lymphatic Abnormalities	8.1%
217	Asthma, Occupational	8.1%
218	Sjogren-Larsson Syndrome	8.1%
219	Neuronal Ceroid-Lipofuscinoses	8.1%
220	Leukemoid Reaction	8%
221	Anti-Glomerular Basement Membrane Disease	7.9%
222	Polycystic Kidney Diseases	7.9%
223	Williams Syndrome	7.9%
224	Agammaglobulinemia	7.8%
225	Fetal Diseases	7.7%
226	Ataxia Telangiectasia	7.7%
227	Refsum Disease	7.7%
228	Bronchospasm	7.7%
229	Bronchiectasis	7.7%
230	Chylothorax	7.7%
231	Hydropneumothorax	7.7%
232	Hydrothorax	7.7%
233	Pneumothorax	7.7%
234	Tracheal Stenosis	7.7%
235	Bronchial Hyperreactivity	7.7%
236	Amyloid Neuropathies, Familial	7.6%
237	Maxillary Sinus Neoplasms	7.5%
238	Amino Acid Metabolism, Inborn Errors	7.5%
239	Carbohydrate Metabolism, Inborn Errors	7.5%
240	Metal Metabolism, Inborn Errors	7.5%
241	Progeria	7.5%
242	Lysosomal Storage Diseases	7.5%
243	Cytochrome-c Oxidase Deficiency	7.5%
244	Peroxisomal Disorders	7.5%
245	Eosinophilia	7.5%
246	Hypoproteinemia	7.5%
247	Leukopenia	7.5%
248	Thrombocytopenia	7.5%
249	Leukostasis	7.5%
250	MYELODYSPLASTIC SYNDROME	7.5%
251	Retinal Dysplasia	7.4%
252	Aniridia	7.3%
253	Invasive Pulmonary Aspergillosis	7.3%
254	Epidermolysis Bullosa	7.3%
255	Asthma, Aspirin-Induced	7.3%
256	Fabry Disease	7.2%
257	Hay fever	7.2%
258	Rhinitis, Allergic, Perennial	7.2%
259	Anemia	7.2%
260	Autoimmune thrombocytopenia	7.1%
261	Immune thrombocytopenic purpura	7.1%
262	Anemia, Megaloblastic	7%
263	Infectious Mononucleosis	7%
264	Atypical Hemolytic Uremic Syndrome	6.8%
265	Waldenstrom Macroglobulinemia	6.8%
266	Laryngomalacia	6.8%
267	Granuloma, Lethal Midline	6.8%
268	Laryngeal Edema	6.8%
269	Nose Deformities, Acquired	6.8%
270	Common Cold	6.7%
271	Hemothorax	6.7%
272	Influenza	6.7%
273	Catarrh	6.7%
274	Cutis Laxa	6.7%
275	Retinitis Pigmentosa	6.7%
276	Pigmentary retinopathy	6.7%
277	Severe Acute Respiratory Syndrome	6.7%
278	Laryngopharyngeal Reflux	6.7%
279	Porokeratosis	6.6%
280	Keratoderma, Palmoplantar	6.6%
281	Leukocytosis	6.6%
282	Paraproteinemias	6.6%
283	Pleocytosis	6.6%
284	Welander Distal Myopathy	6.6%
285	Galactosemias	6.5%
286	Urea Cycle Disorders, Inborn	6.5%
287	Tyrosinemias	6.5%
288	Cryoglobulinemia	6.4%
289	Monoclonal Gammopathy of Undetermined Significance	6.4%
290	Canavan Disease	6.3%
291	Alexander Disease	6.3%
292	Glycogen storage disease type II	6.2%
293	Zellweger Syndrome	6.2%
294	Lymphangiectasis, Intestinal	6.1%
295	Duane Retraction Syndrome	6.1%
296	Optic Atrophy, Hereditary, Leber	6.1%
297	Kernicterus	6%
298	Pharyngitis	6%
299	Hyperphosphaturia	6%
300	Porphyrias, Hepatic	6%
301	Nasal Polyps	6%
302	Peutz-Jeghers Syndrome	6%
303	Myotonia Congenita	6%
304	Brain Diseases, Metabolic, Inborn	6%
305	Dystonia Musculorum Deformans	5.9%
306	Pertussis	5.9%
307	Lafora Disease	5.9%
308	Unverricht-Lundborg Syndrome	5.9%
309	Hypergammaglobulinemia	5.9%
310	Lung diseases	5.9%
311	Respiration Disorders	5.9%
312	Purpura, Hyperglobulinemic	5.8%
313	Ecchymosis	5.8%
314	Petechiae	5.8%
315	Purpura	5.8%
316	Xeroderma Pigmentosum	5.7%
317	Epiglottitis	5.7%
318	Mediastinitis	5.7%
319	Multiple Endocrine Neoplasia	5.5%
320	Waterhouse-Friderichsen Syndrome	5.5%
321	Heavy Chain Disease	5.5%
322	Congenital Hypothyroidism	5.5%
323	Dermatitis, Atopic	5.4%
324	Voice Disorders	5.4%
325	Voice Disturbance	5.4%
326	Epistaxis	5.4%
327	Multiple Myeloma	5.4%
328	Xeroderma	5.4%
329	Mobius Syndrome	5.4%
330	Mucopolysaccharidosis III	5.3%
331	Homocystinuria	5.3%
332	Bronchomalacia	5.3%
333	Tracheomalacia	5.3%
334	Leigh Disease	5.3%
335	Basal Cell Nevus Syndrome	5.3%
336	Polycystic Kidney, Autosomal Dominant	5.2%
337	POEMS Syndrome	5.2%
338	Classical Lissencephalies and Subcortical Band Heterotopias	5.2%
339	Hyperkeratosis, Epidermolytic	5.2%
340	Mediastinal Cyst	5%
341	Pericardial Cyst	5%
342	Thymic Cyst	5%
343	Thrombocytopenic purpura	5%
344	Croup	5%
345	Mediastinal Emphysema	5%
346	Rhinitis, Vasomotor	5%
347	Behcet Syndrome	5%
348	Alkaptonuria	4.9%
349	Glycogen Storage Disease	4.9%
350	Hypophosphatasia	4.9%
351	Propionic acidemia	4.9%
352	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
353	Cystinosis	4.9%
354	Vocal Cord Paralysis	4.9%
355	Gaucher Disease	4.8%
356	Abdominal Cramps	4.8%
357	Abnormalities, Drug-Induced	4.8%
358	Amniotic Band Syndrome	4.8%
359	Asphyxia Neonatorum	4.8%
360	Infant, Premature, Diseases	4.8%
361	Situs Inversus	4.8%
362	Infantile Colic	4.8%
363	Charcot-Marie-Tooth Disease	4.8%
364	Antley-Bixler Syndrome Phenotype	4.8%
365	Primary Myelofibrosis	4.6%
366	Agranulocytosis	4.6%
367	Lymphocytosis	4.6%
368	Myelofibrosis	4.6%
369	Myeloid Metaplasia	4.6%
370	Hypoalbuminemia	4.6%
371	Hypereosinophilic syndrome	4.6%
372	bone marrow fibrosis	4.6%
373	Thrombotic Microangiopathies	4.6%
374	Huntington Disease	4.6%
375	Niemann-Pick Disease, Type C	4.5%
376	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.5%
377	Tonsillitis	4.4%
378	Adenitis	4.4%
379	Histiocytosis	4.4%
380	Lymphadenitis	4.4%
381	Lymphangitis	4.4%
382	Lymphedema	4.4%
383	Splenic Diseases	4.4%
384	Thymus Hyperplasia	4.4%
385	Pseudolymphoma	4.4%
386	Lymphadenopathy	4.4%
387	Hypolipoproteinemias	4.4%
388	Papillon-Lefevre Disease	4.4%
389	Hyperlipidemia, Familial Combined	4.4%
390	Hyperlipoproteinemia Type III	4.4%
391	Eye Abnormalities	4.3%
392	Cardiovascular Abnormalities	4.3%
393	Anemia, Hemolytic	4.3%
394	Nephroblastoma	4.2%
395	Skin Abnormalities	4.2%
396	Congenital Microtia	4.2%
397	Congenital diaphragmatic hernia	4.2%
398	Umbilical hernia	4.2%
399	Tay-Sachs Disease	4.1%
400	Lymphopenia	4.1%
401	Job Syndrome	4%
402	Leukemia, Myelomonocytic, Chronic	4%
403	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4%
404	Anemia, Pernicious	4%
405	Familial Periodic Paralysis	4%
406	Aphonia	4%
407	Retropharyngeal Abscess	4%
408	Dysphonia	4%
409	Lactose Intolerance	4%
410	Variegate Porphyria	4%
411	Acute intermittent porphyria	4%
412	Porphyria Cutanea Tarda	4%
413	Hyperhomocysteinemia	3.9%
414	Renal Aminoacidurias	3.9%
415	Fanconi Syndrome	3.9%
416	Pseudohypoaldosteronism	3.9%
417	Liddle Syndrome	3.9%
418	Adenomatous Polyposis Coli	3.9%
419	Hyperlipoproteinemia Type IV	3.9%
420	Hyperlipoproteinemia Type V	3.9%
421	Lymphocele	3.9%
422	Lymphoproliferative Disorders	3.9%
423	Thymus Neoplasms	3.9%
424	Urogenital Abnormalities	3.8%
425	Neonatal Abstinence Syndrome	3.8%
426	Turner Syndrome	3.8%
427	Klinefelter Syndrome	3.8%
428	Fetal Growth Retardation	3.7%
429	Fetal Hypoxia	3.7%
430	Congenital nystagmus	3.7%
431	Fetal Alcohol Spectrum Disorders	3.7%
432	Glycogen Storage Disease Type I	3.7%
433	Glycogen Storage Disease Type V	3.7%
434	Toxoplasmosis, Congenital	3.7%
435	Anencephaly	3.7%
436	Syphilis, Congenital	3.7%
437	Gout	3.6%
438	Nasopharyngitis	3.6%
439	Eosinophilia-Myalgia Syndrome	3.6%
440	Multiple Endocrine Neoplasia Type 1	3.6%
441	Pseudohypoparathyroidism	3.6%
442	Shwartzman Phenomenon	3.6%
443	Friedreich Ataxia	3.6%
444	Hemangioma, Cavernous	3.6%
445	Renal tubular acidosis	3.6%
446	Scurvy	3.6%
447	Purpura Fulminans	3.6%
448	Mucocutaneous Lymph Node Syndrome	3.4%
449	Congenital Hyperinsulinism	3.3%
450	Chorioamnionitis	3.3%
451	Maxillofacial Abnormalities	3.3%
452	Dural Arteriovenous Fistula	3.3%
453	Dextrocardia	3.3%
454	Peritonsillar Abscess	3.3%
455	Hypoalphalipoproteinemias	3.3%
456	Familial Hypophosphatemic Rickets	3.2%
457	Neutropenia	3.2%
458	Abnormalities, Radiation-Induced	3%
459	Glycosuria, Renal	3%
460	Hypokalemic periodic paralysis	3%
461	Cystinuria	2.9%
462	Prune Belly Syndrome	2.8%
463	Twins, Conjoined	2.8%
464	Waardenburg Syndrome	2.8%
465	Leukemia, Myeloid, Chronic-Phase	2.8%
466	Ophthalmia Neonatorum	2.7%
467	Denys-Drash Syndrome	2.7%
468	Arthritis, Gouty	2.7%
469	MELAS Syndrome	2.6%
470	Anophthalmos	2.5%
471	Anus, Imperforate	2.5%
472	Hydranencephaly	2.5%
473	Microphthalmos	2.5%
474	Neural Tube Defects	2.5%
475	Paralysis, Obstetric	2.5%
476	Retinopathy of Prematurity	2.5%
477	Tethered Cord Syndrome	2.5%
478	Iniencephaly	2.5%
479	Craniorachischisis	2.5%
480	Limb Deformities, Congenital	2.5%
481	Exencephaly	2.5%
482	Septo-Optic Dysplasia	2.5%
483	Craniofacial Abnormalities	2.5%
484	Cortical Dysplasia	2.5%
485	Malformations of Cortical Development	2.5%
486	Anorectal Malformations	2.5%
487	Bloom Syndrome	2.5%
488	Elephantiasis	2.5%
489	Hypersplenism	2.5%
490	Sarcoidosis	2.5%
491	Elephantiasis Nostras Verrucosa	2.5%
492	Febrile Neutropenia	2.5%
493	Acrocephalosyndactylia	2.4%
494	Craniosynostosis	2.4%
495	Syndactyly	2.4%
496	Brachycephaly	2.4%
497	Microcephaly	2.3%
498	Macrocephaly	2.3%
499	Blepharophimosis	2.2%
500	Mouth Abnormalities	2.2%
501	Esophageal Atresia	2.2%
502	Intestinal Atresia	2.2%
503	Horseshoe Kidney	2.2%
504	Pectus excavatum	2.2%
505	Klippel-Feil Syndrome	2.2%
506	Gastroschisis	2.2%
507	Synostosis	2.2%
508	Noonan Syndrome	2.2%
509	Acrodermatitis	2.2%
510	Gianotti-Crosti Syndrome	2.2%
511	Granuloma	2.2%
512	Histiocytic Disorders, Malignant	2.2%
513	Splenic Infarction	2.2%
514	Splenic Neoplasms	2.2%
515	Tumor Lysis Syndrome	2.2%
516	Cleft Palate	2.1%
517	Arthrogryposis	2%
518	Choledochal Cyst	2%
519	Hermaphroditism	2%
520	Disorders of Sex Development	2%
521	Cryptorchidism	2%
522	Hypospadias	2%
523	Sezary Syndrome	2%
524	Central Nervous System Cysts	2%
525	Dandy-Walker Syndrome	2%
526	Leukomalacia, Periventricular	2%
527	Nesidioblastosis	2%
528	Splenic Rupture	2%
529	Porencephaly	2%
530	Lymphoma	2%
531	Jaw Abnormalities	1.9%
532	Thymoma	1.9%
533	Pectus carinatum	1.8%
534	Bladder Exstrophy	1.8%
535	Epispadias	1.8%
536	Multicystic Dysplastic Kidney	1.8%
537	Poland Syndrome	1.8%
538	Amelia	1.7%
539	Arachnodactyly	1.7%
540	Ectopia Cordis	1.7%
541	Ectromelia	1.7%
542	Hemimelia	1.7%
543	Meningomyelocele	1.7%
544	Phocomelia	1.7%
545	Sirenomelia	1.7%
546	Spina Bifida	1.7%
547	Polydactyly	1.7%
548	Brachydactyly	1.7%
549	Plagiocephaly	1.7%
550	Lower Extremity Deformities, Congenital	1.7%
551	Upper Extremity Deformities, Congenital	1.7%
552	Single umbilical artery	1.7%
553	Lymphohistiocytosis, Hemophagocytic	1.5%
554	Erdheim-Chester Disease	1.5%
555	Micrognathism	1.5%
556	Pierre Robin Syndrome	1.5%
557	Aortic coarctation	1.5%
558	Cor Triatriatum	1.5%
559	Coronary Vessel Anomalies	1.5%
560	Dental Enamel Hypoplasia	1.5%
561	Patent ductus arteriosus	1.5%
562	Ebstein Anomaly	1.5%
563	Heart Septal Defects	1.5%
564	Hypodontia	1.5%
565	Macrostomia	1.5%
566	Meningocele	1.5%
567	Microstomia	1.5%
568	Tetralogy of Fallot	1.5%
569	Transposition of Great Vessels	1.5%
570	Hypoplastic Left Heart Syndrome	1.5%
571	May-Thurner Syndrome	1.5%
572	Encephalocele	1.5%
573	Craniofacial Dysostosis	1.5%
574	Wolff-Parkinson-White Syndrome	1.5%
575	Hyperandrogenism	1.4%
576	Retrognathia	1.4%
577	Malignant histiocytosis	1.3%
578	Histiocytic sarcoma	1.3%
579	Long QT Syndrome	1.3%
580	Platybasia	1.3%
581	Tricuspid Atresia	1.3%
582	Arrhythmogenic Right Ventricular Dysplasia	1.3%
583	Gonadal Dysgenesis	1.3%
584	Adrenogenital Syndrome	1.3%
585	Ovotesticular Disorders of Sex Development	1.3%
586	Prognathism	1.3%
587	Dermal Sinus	1.2%
588	Spina Bifida Cystica	1.2%
589	Spina Bifida Occulta	1.2%
590	Lissencephaly	1.2%
591	Polymicrogyria	1.2%
592	Pachygyria	1.2%
593	Schizencephaly	1.2%
594	Periventricular Nodular Heterotopia	1.2%
595	Splenosis	1.2%
596	Hodgkin Disease	1.2%
597	Lymphoma, Non-Hodgkin	1.2%
598	Leukemia, T-Cell	1.2%
599	Leukemia, B-Cell	1.2%
600	Aortopulmonary Septal Defect	1.1%
601	Double Outlet Right Ventricle	1.1%
602	Endocardial Cushion Defects	1.1%
603	Myocardial bridging	1.1%
604	Aorticopulmonary Septal Defect	1.1%
605	Composite Lymphoma	1.1%
606	Lymphangioleiomyomatosis	1.1%
607	Mandibulofacial Dysostosis	1%
608	Romano-Ward Syndrome	1%
609	Truncus Arteriosus, Persistent	0.9%
610	Goldenhar Syndrome	0.9%
611	Talipes	0.8%
612	Arteriovenous fistula	0.8%
613	Lymphoma, Follicular	0.8%
614	T-Cell Lymphoma	0.8%
615	Mantle cell lymphoma	0.8%
616	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
617	Leukemia, Large Granular Lymphocytic	0.8%
618	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
619	Congenital clubfoot	0.7%
620	Vertical Talus	0.7%
621	Lymphoma, T-Cell, Cutaneous	0.6%
622	Lymphoma, AIDS-Related	0.6%
623	Enteropathy-Associated T-Cell Lymphoma	0.6%
624	Primary Effusion Lymphoma	0.6%
625	Lymphomatoid Granulomatosis	0.6%
626	Mycosis Fungoides	0.5%
627	Lymphomatoid Papulosis	0.5%
628	Plasmablastic lymphoma	0.5%
629	Burkitt Lymphoma	0.5%

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