MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spastic Paraplegia

(UMLS:C0037772)

UMLS ID:: C0037772
MeSH ID:: D010264

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.622.669

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.592.636.637

Synonym(s)

Spastic Paraplegia

Erb syndrome

Erb-Charcot syndrome

Spastic paraplegia

Spastic paraplegia syndrome

Spastic paraplegia, lower limb

hypertonic; paraplegia

paralysis spinalis spastica

paraplegia spastic

10.

paraplegia spastica

11.

paraplegia; hypertonic

12.

paraplegia; spastic

13.

spastic paraplegia

14.

spastic paraplegia (SP)

15.

spastic spinal paralysis

16.

spastic; paraplegia

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Prednisolone	FAERS: 3	US FAERS
2	Atovaquone	FAERS: 1	US FAERS
3	Methylprednisolone Hemisuccinate	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Hemiplegia	47.5%
2	Locked-In Syndrome	47.5%
3	Pseudobulbar Palsy	47.5%
4	Quadriplegia	47.5%
5	Monoplegia	47.5%
6	Quadriparesis	47.5%
7	Facial paralysis	38.7%
8	Facial Paresis	38.7%
9	Respiratory Paralysis	38.2%
10	Ophthalmoplegia	34.4%
11	External Ophthalmoplegia	34.4%
12	Decerebrate State	32.8%
13	Hemiparesis	32.8%
14	Meningism	32.8%
15	Paresis	32.8%
16	Seizures	32.8%
17	Sensation Disorders	32.8%
18	Complex partial seizures	32.8%
19	Monoparesis	32.8%
20	Gait Disorders, Neurologic	32.8%
21	Neuromuscular Manifestations	32.8%
22	Vocal Cord Paralysis	29.8%
23	Asterixis	28.9%
24	Ballismus	28.9%
25	Pupil Disorders	27.3%
26	Neurobehavioral Manifestations	27.3%
27	Vertigo	26%
28	Gait Ataxia	24.7%
29	Gastroparesis	24.6%
30	Psychophysiologic Disorders	23.1%
31	Ophthalmoplegic Migraine	22.3%
32	Sleep Wake Disorders	22.3%
33	Voice Disorders	22.3%
34	Voice Disturbance	22.3%
35	Anosmia	21.3%
36	Ataxia	21.3%
37	Athetosis	21.3%
38	Catalepsy	21.3%
39	Dystonia	21.3%
40	Muscle Hypertonia	21.3%
41	Muscle hypotonia	21.3%
42	Myoclonus	21.3%
43	Myotonia	21.3%
44	Spasm	21.3%
45	Status Epilepticus	21.3%
46	Taste Disorders	21.3%
47	Tremor	21.3%
48	Hypokinesia	21.3%
49	Paraparesis	21.3%
50	Bradykinesia	21.3%
51	Waxy flexibility	21.3%
52	Action Tremor	21.3%
53	Resting Tremor	21.3%
54	Dysosmia	21.3%
55	Olfaction Disorders	21.3%
56	Myokymia	21.3%
57	Somatosensory Disorders	21.3%
58	Hyperkinesia	21.3%
59	Intention tremor	21.3%
60	Akathisia	21.2%
61	Restlessness	21.2%
62	Psychomotor Agitation	21.2%
63	Progressive supranuclear palsy	20.9%
64	Orthostatic intolerance	20.7%
65	Gait Apraxia	19.5%
66	Muscular Atrophy	19.1%
67	Chorea	19%
68	Abdominal Pain	18.9%
69	Reflex, Abnormal	18.4%
70	Hyporeflexia	18.4%
71	Hyperreflexia	18.4%
72	Vision Disorders	17.8%
73	Metamorphopsia	17.8%
74	Visual Impairment	17.8%
75	Neurogenic Inflammation	17.6%
76	Muscle Weakness	17.4%
77	Anisocoria	17.3%
78	Confusion	17.3%
79	Lethargy	17.3%
80	Memory Disorders	17.3%
81	Muscle Cramp	17.3%
82	Perceptual Disorders	17.3%
83	Psychomotor Disorders	17.3%
84	Tonic Pupil	17.3%
85	Anhedonia	17.3%
86	Disorientation	17.3%
87	Memory Loss	17.3%
88	Hemisensory Neglect	17.3%
89	Dysacusis	17.3%
90	Polydipsia	17.1%
91	Tetany	17%
92	Asthenia	16.9%
93	Body Temperature Changes	16.9%
94	Cyanosis	16.9%
95	Edema	16.9%
96	Failure to Thrive	16.9%
97	Fatigue	16.9%
98	Feminization	16.9%
99	Fetal Distress	16.9%
100	Motion Sickness	16.9%
101	Signs and Symptoms, Digestive	16.9%
102	Signs and Symptoms, Respiratory	16.9%
103	Skin Manifestations	16.9%
104	Chills	16.9%
105	Lassitude	16.9%
106	Pseudophakia	16.9%
107	Urological Manifestations	16.9%
108	Mobility Limitation	16.9%
109	Somnolence	16.9%
110	Alice in Wonderland Syndrome	16.6%
111	Renal Colic	15.9%
112	Dysgeusia	15.8%
113	Formication	15.8%
114	Hyperalgesia	15.8%
115	Hyperesthesia	15.8%
116	Hypesthesia	15.8%
117	Language Disorders	15.8%
118	Numbness	15.8%
119	Paresthesia	15.8%
120	Paraparesis, Spastic	15.8%
121	Trismus	15.8%
122	Epilepsia Partialis Continua	15.8%
123	Hypogeusia	15.8%
124	Lockjaw	15.8%
125	Allodynia	15.8%
126	Ageusia	15.8%
127	Cerebrospinal Fluid Otorrhea	15.8%
128	Cerebrospinal Fluid Rhinorrhea	15.8%
129	Eye pain	15.3%
130	Back Pain	15.2%
131	Neck Pain	15.2%
132	Chest Pain	15.2%
133	Dizziness	15.2%
134	Facial Pain	15.2%
135	Flank Pain	15.2%
136	Headache	15.2%
137	Pain, Intractable	15.2%
138	Pelvic Pain	15.2%
139	Chronic pain	15.2%
140	Lightheadedness	15.2%
141	Pain, Referred	15.2%
142	Throbbing Headache	15.2%
143	Labor Pain	15.2%
144	Cancer Pain	15.2%
145	Nociceptive Pain	15.2%
146	Alexia	14.9%
147	Dyslexia	14.9%
148	Phantom pain	14.8%
149	Phantom Limb Pain	14.8%
150	Neuralgia	14.8%
151	Neuropathic pain	14.8%
152	Dyskinesia, Drug-Induced	14.6%
153	Consciousness Disorders	14.6%
154	Mental Retardation	14.6%
155	Depressed Level of Consciousness	14.6%
156	Mental deficiency	14.6%
157	Intellectual Disability	14.6%
158	Hoarseness	14.6%
159	Cerebellar Ataxia	14.6%
160	Torticollis	14.6%
161	Catatonia	14.4%
162	Aphonia	14.3%
163	Dysphonia	14.3%
164	Tardive Dyskinesia	14.2%
165	Horner Syndrome	14%
166	Pain, Postoperative	13.9%
167	Sarcopenia	13.9%
168	Pain	13.9%
169	Ache	13.9%
170	Abdomen, Acute	13.4%
171	Eye Manifestations	13.3%
172	Agraphia	13.1%
173	Anomia	13.1%
174	Cluttering	13.1%
175	Language Development Disorders	13.1%
176	Speech Disorders	13.1%
177	Syncope	13.1%
178	Stupor	13.1%
179	Dysgraphia	13.1%
180	Presyncope	13.1%
181	Dyslalia	13.1%
182	Amblyopia	12.9%
183	Diplopia	12.9%
184	Muscle Rigidity	12.9%
185	Muscle Spasticity	12.9%
186	Scotoma	12.9%
187	Photophobia	12.9%
188	Cogwheel Rigidity	12.9%
189	Hemifacial Spasm	12.9%
190	Amaurosis	12.9%
191	Blindness	12.9%
192	Nuchal Rigidity	12.9%
193	Cardiac Output, High	12.8%
194	Myocardial Stunning	12.8%
195	Reticulocytosis	12.8%
196	Low Cardiac Output Syndrome	12.8%
197	Agnosia	12.7%
198	Apraxias	12.7%
199	Hallucinations	12.7%
200	Hemianopsia	12.7%
201	Hyperacusis	12.7%
202	Tinnitus	12.7%
203	Visual Agnosia	12.7%
204	Anosognosia	12.7%
205	Wernicke-Korsakoff Syndrome	12.7%
206	Phonophobia	12.7%
207	Hearing Loss	12.7%
208	Intermittent Claudication	12.5%
209	Persistent Vegetative State	12.4%
210	Alcohol Withdrawal Seizures	12.3%
211	Cranial nerve diseases	11.8%
212	Demyelinating Diseases	11.8%
213	Demyelination	11.8%
214	Neuromuscular Diseases	11.8%
215	Chronobiology Disorders	11.8%
216	Aphasia	11.7%
217	Articulation Disorders	11.7%
218	Echolalia	11.7%
219	Stuttering	11.7%
220	Dysphasia	11.7%
221	Low Back Pain	11.4%
222	Visceral Pain	11.4%
223	Kearns-Sayre syndrome	11.1%
224	Dysarthria	11.1%
225	Dysmenorrhea	11%
226	Failed Back Surgery Syndrome	11%
227	Amnesia	10.7%
228	Delirium	10.7%
229	Dissociative Amnesia	10.7%
230	Color blindness	10.7%
231	Global Amnesia	10.7%
232	Pathological Conditions, Anatomical	10.6%
233	Amaurosis Fugax	10.5%
234	Blindness, Cortical	10.5%
235	Dyscalculia	10.5%
236	Deafness	10.5%
237	Hearing Loss, Sudden	10.5%
238	Gerstmann Syndrome	10.5%
239	Hearing Loss, Bilateral	10.5%
240	Hearing Loss, High-Frequency	10.5%
241	Hearing Loss, Mixed Conductive-Sensorineural	10.5%
242	Prosopagnosia	10.5%
243	Apraxia, Ideomotor	10.5%
244	Charles Bonnet Syndrome	10.5%
245	Hearing Loss, Unilateral	10.5%
246	Complete Hearing Loss	10.5%
247	Alien Hand Syndrome	10.5%
248	Deaf Mutism	10.5%
249	Sciatica	10.3%
250	Motor Neuron Disease	10.3%
251	Hypergammaglobulinemia	10.2%
252	jaundice	9.9%
253	Anorexia	9.9%
254	Anoxia	9.9%
255	Constipation	9.9%
256	Diarrhea	9.9%
257	Dyspepsia	9.9%
258	Eructation	9.9%
259	Fever	9.9%
260	Flatulence	9.9%
261	Flushing	9.9%
262	Halitosis	9.9%
263	Heartburn	9.9%
264	Hiccough	9.9%
265	Hypercalciuria	9.9%
266	Hypercapnia	9.9%
267	Hyperphagia	9.9%
268	Nausea	9.9%
269	Pallor	9.9%
270	Sleep Deprivation	9.9%
271	Vomiting	9.9%
272	Hypocapnia	9.9%
273	Dyschezia	9.9%
274	Hypoxia	9.9%
275	Hyperoxia	9.9%
276	Lower Urinary Tract Symptoms	9.9%
277	Hypoxemia	9.9%
278	Urinoma	9.9%
279	Akathisia, Drug-Induced	9.8%
280	Postoperative Nausea and Vomiting	9.8%
281	Mutism	9.6%
282	Selective Mutism	9.6%
283	Metatarsalgia	9.5%
284	Multiple System Atrophy	9.4%
285	Amnesia, Transient Global	9.4%
286	Mastodynia	9.2%
287	Trauma, Nervous System	9.2%
288	Auditory Perceptual Disorders	9.2%
289	Breakthrough Pain	9.2%
290	Subacute Combined Degeneration	9.1%
291	Stiff-Person Syndrome	9%
292	Brain Death	9%
293	Alexia, Pure	8.9%
294	Nervous System Neoplasms	8.8%
295	Neurotoxicity Syndromes	8.8%
296	Retrograde amnesia	8.8%
297	Amnesia, Anterograde	8.8%
298	Toothache	8.7%
299	Jet Lag Syndrome	8.5%
300	Ocular Motility Disorders	8.5%
301	Cyclophoria	8.5%
302	Polyradiculoneuropathy	8.4%
303	Polyradiculoneuritis	8.4%
304	Encephalomyelitis	8.4%
305	Prion Diseases	8.4%
306	Autonomic Dysreflexia	8.4%
307	Complex Regional Pain Syndromes	8.4%
308	Eye Hemorrhage	8.3%
309	Restless Legs Syndrome	8.2%
310	Hemoptysis	8.1%
311	Ecchymosis	7.9%
312	Spinal Muscular Atrophy	7.9%
313	Petechiae	7.9%
314	Purpura	7.9%
315	Progressive Muscular Atrophy	7.9%
316	Musculoskeletal Pain	7.8%
317	Opsoclonus-Myoclonus Syndrome	7.7%
318	Arthralgia	7.7%
319	Polyarthralgia	7.7%
320	Meningoencephalitis	7.7%
321	Parkinson Disease	7.6%
322	Apnea	7.6%
323	Cheyne-Stokes Respiration	7.6%
324	Dyspnea	7.6%
325	Hyperventilation	7.6%
326	Mouth Breathing	7.6%
327	Pruritus	7.6%
328	Sneezing	7.6%
329	Erythema	7.6%
330	Necrolytic Migratory Erythema	7.6%
331	Tachypnea	7.6%
332	Amyotrophic Lateral Sclerosis	7.5%
333	Marchiafava-Bignami Disease	7.5%
334	Edema, Cardiac	7.4%
335	Mental Fatigue	7.4%
336	Hirsutism	7.4%
337	Hypoventilation	7.4%
338	Body Weight Changes	7.3%
339	Coma, Post-Head Injury	7%
340	Body Weight	7%
341	Spinal Cord Injuries	7%
342	Vascular Remodeling	6.9%
343	Angina Pectoris	6.9%
344	Myalgia	6.8%
345	Lewy Body Disease	6.8%
346	Peripheral Nerve Injuries	6.8%
347	Guillain-Barre Syndrome	6.8%
348	Epistaxis	6.8%
349	Striatonigral Degeneration	6.8%
350	Brain Diseases	6.7%
351	Dysautonomia	6.7%
352	Meningitis	6.7%
353	Movement Disorders	6.7%
354	Pachymeningitis	6.7%
355	Spinal Cord Diseases	6.7%
356	Vagus Nerve Disorder	6.7%
357	Glossopharyngeal Neuralgia	6.7%
358	Abducens Nerve Diseases	6.7%
359	Heavy Metal Poisoning, Nervous System	6.7%
360	Neuromuscular Junction Diseases	6.7%
361	Tauopathies	6.7%
362	Trochlear Nerve Diseases	6.7%
363	Peripheral Nervous System Diseases	6.7%
364	Myasthenia Gravis	6.7%
365	Dandy-Walker Syndrome	6.6%
366	Myelitis	6.6%
367	Progressive bulbar palsy	6.6%
368	Bulbar palsy	6.6%
369	Pneumocephalus	6.6%
370	Poliomyelitis	6.6%
371	Causalgia	6.5%
372	Bulimia	6.5%
373	Dysuria	6.5%
374	Fever of Unknown Origin	6.5%
375	Nocturia	6.5%
376	Snoring	6.5%
377	Prostatism	6.5%
378	Jaundice, Obstructive	6.5%
379	Leukoencephalitis, Acute Hemorrhagic	6.1%
380	Pleural Rub	6%
381	Rales	6%
382	Respiratory Sounds	6%
383	Rhonchi	6%
384	Stridor	6%
385	Wheezing	6%
386	Epidural Abscess	6%
387	Olfactory Nerve Injuries	6%
388	Neuroleptic Malignant Syndrome	6%
389	Myelinolysis, Central Pontine	6%
390	Livedo Reticularis	6%
391	Miller Fisher Syndrome	6%
392	Oliguria	5.9%
393	Polyuria	5.9%
394	Proteinuria	5.9%
395	Myelitis, Transverse	5.9%
396	MPTP Poisoning	5.9%
397	Chronic Fatigue Syndrome	5.8%
398	Lambert-Eaton Myasthenic Syndrome	5.8%
399	Underweight	5.8%
400	Overweight	5.8%
401	Shy-Drager Syndrome	5.8%
402	Sleep Disorders, Circadian Rhythm	5.8%
403	Reflex Sympathetic Dystrophy	5.7%
404	Subdural Effusion	5.7%
405	Parkinsonian Disorders	5.7%
406	Nocturnal Myoclonus Syndrome	5.7%
407	Encephalomyelitis, Acute Disseminated	5.7%
408	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.7%
409	Shoulder Pain	5.7%
410	Angina, Unstable	5.7%
411	Ascites	5.6%
412	Calculi	5.6%
413	Fibrosis	5.6%
414	Gliosis	5.6%
415	Growth Disorders	5.6%
416	Hemorrhage	5.6%
417	Hernia	5.6%
418	Hyperbilirubinemia	5.6%
419	Hyperplasia	5.6%
420	Hypertrophy	5.6%
421	Hypomenorrhea	5.6%
422	Inflammation	5.6%
423	Intraoperative Complications	5.6%
424	Ischemia	5.6%
425	Lithiasis	5.6%
426	Malacoplakia	5.6%
427	Menstruation Disturbances	5.6%
428	Metaplasia	5.6%
429	Nails, Malformed	5.6%
430	Nerve Degeneration	5.6%
431	Ochronosis	5.6%
432	Polymenorrhea	5.6%
433	polyps	5.6%
434	Postoperative Complications	5.6%
435	Rupture, Spontaneous	5.6%
436	Sclerosis	5.6%
437	Shock	5.6%
438	Ulcer	5.6%
439	Enterocele	5.6%
440	Hyperammonemia	5.6%
441	Hyperamylasemia	5.6%
442	Teratogenesis	5.6%
443	Atheroma	5.6%
444	Cardiac Death	5.6%
445	Hypovolemia	5.6%
446	Hyperuricemia	5.6%
447	Leukoaraiosis	5.6%
448	Stenosis	5.6%
449	Facial asymmetry	5.6%
450	Dysbacteriosis	5.6%
451	Delayed Graft Function	5.6%
452	Cirrhosis	5.6%
453	Plaque, Amyloid	5.6%
454	Plaque, Atherosclerotic	5.6%
455	Neointima	5.6%
456	Dysbiosis	5.6%
457	Ataxia Telangiectasia	5.6%
458	Botulism	5.6%
459	Central Nervous System Cysts	5.6%
460	Neuromyelitis Optica	5.5%
461	Dystonia Musculorum Deformans	5.5%
462	Central Nervous System Infection	5.3%
463	Myopathy	5.3%
464	Optic Neuropathy	5.3%
465	Brain Injuries	5.3%
466	Brain Neoplasms	5.3%
467	Multiple Sclerosis	5.3%
468	Spinal Cord Neoplasms	5.3%
469	Hematemesis	5.2%
470	Purpura Fulminans	5.2%
471	Facial Nerve Injuries	5.2%
472	Facial Nerve Diseases	5.1%
473	Craniocerebral Trauma	5.1%
474	Parasomnia	5.1%
475	Dyssomnias	5.1%
476	Angina Pectoris, Variant	5.1%
477	Vestibulocochlear Nerve Diseases	5%
478	Hydranencephaly	5%
479	Neural Tube Defects	5%
480	Tethered Cord Syndrome	5%
481	Central Nervous System Neoplasms	5%
482	Iniencephaly	5%
483	Craniorachischisis	5%
484	Exencephaly	5%
485	Septo-Optic Dysplasia	5%
486	Cortical Dysplasia	5%
487	Malformations of Cortical Development	5%
488	Gagging	5%
489	Sweating, Gustatory	5%
490	Auriculotemporal Syndrome	5%
491	Morning Sickness	5%
492	Infarction	5%
493	Postoperative Hemorrhage	5%
494	Shock, Hemorrhagic	5%
495	Systemic Inflammatory Response Syndrome	5%
496	Incisional hernia	5%
497	Cri-du-Chat Syndrome	4.9%
498	Down Syndrome	4.9%
499	Trisomy 21	4.9%
500	Leukoencephalopathy, Progressive Multifocal	4.9%
501	Williams Syndrome	4.9%
502	Meige Syndrome	4.9%
503	Brachial Plexus Neuritis	4.9%
504	Neuralgic Amyotrophy	4.9%
505	Cerebral Ventriculitis	4.9%
506	Emaciation	4.9%
507	Epilepsy, Post-Traumatic	4.9%
508	Rett Syndrome	4.9%
509	Weight Gain	4.8%
510	Limbic Encephalitis	4.7%
511	Scrapie	4.7%
512	Central Cord Syndrome	4.7%
513	Presenile dementia	4.6%
514	Senile dementia	4.6%
515	Meningocele	4.6%
516	Meningitis, Bacterial	4.6%
517	Meningitis, Fungal	4.6%
518	Encephalocele	4.6%
519	Acrodynia	4.6%
520	Huntington Disease	4.6%
521	Myasthenia Gravis, Autoimmune, Experimental	4.5%
522	Lafora Disease	4.5%
523	Unverricht-Lundborg Syndrome	4.5%
524	Tarsal Tunnel Syndrome	4.5%
525	Cauda Equina Syndrome	4.5%
526	Posterior Leukoencephalopathy Syndrome	4.5%
527	Posterior reversible encephalopathy syndrome	4.5%
528	Brain Abscess	4.4%
529	Cyst	4.4%
530	Extravasation of Diagnostic and Therapeutic Materials	4.4%
531	Neoplastic Processes	4.4%
532	Charcot-Marie-Tooth Disease	4.4%
533	Akinetic Mutism	4.4%
534	Anoxic Encephalopathy	4.4%
535	Arachnoiditis	4.4%
536	Basal Ganglia Diseases	4.4%
537	Brain Damage, Chronic	4.4%
538	Cerebellar Diseases	4.4%
539	Encephalitis	4.4%
540	Encephalomalacia	4.4%
541	Epilepsy	4.4%
542	Hydrocephalus	4.4%
543	Congenital Hydrocephalus	4.4%
544	Hypothalamic Diseases	4.4%
545	Aseptic Meningitis	4.4%
546	Neuritis	4.4%
547	Polyneuritis	4.4%
548	Radiculitis	4.4%
549	Syringomyelia	4.4%
550	Thalamic Diseases	4.4%
551	Intracranial Hypertension	4.4%
552	Polyneuropathy	4.4%
553	Mononeuritis	4.4%
554	Aura	4.4%
555	Leukoencephalopathy	4.4%
556	Essential Tremor	4.4%
557	Neuroaxonal Dystrophies	4.4%
558	Familial Tremor	4.4%
559	Headache Disorders	4.4%
560	Mononeuropathies	4.4%
561	Intracranial Hypotension	4.4%
562	Brachial Plexus Neuropathies	4.4%
563	Radiculopathy	4.4%
564	Mononeuropathy Multiplex	4.4%
565	Nerve Root Compression	4.4%
566	Brain Edema	4.4%
567	Brain Hypoxia	4.4%
568	Aqueductal Stenosis	4.4%
569	Pneumorrhachis	4.4%
570	Writer's Cramp	4.4%
571	Lupus Vasculitis, Central Nervous System	4.4%
572	Vasculitis, Central Nervous System	4.3%
573	Cerebellar Neoplasms	4.3%
574	Leukoplakia	4.3%
575	Necrosis	4.3%
576	Granulomatosis, Orofacial	4.3%
577	Pigmentation Disorders	4.3%
578	Respiratory Aspiration	4.3%
579	Airway Remodeling	4.3%
580	Prader-Willi Syndrome	4.2%
581	Acantholysis	4.2%
582	Chromosome Aberrations	4.2%
583	Dehydration	4.2%
584	Granuloma	4.2%
585	Leukocytosis	4.2%
586	Pleocytosis	4.2%
587	Ventricular Remodeling	4.2%
588	Alopecia	4.2%
589	Androgenetic Alopecia	4.2%
590	Birth Weight	4.1%
591	Canavan Disease	4.1%
592	Alexander Disease	4.1%
593	Paraneoplastic Encephalomyelitis	4.1%
594	Cachexia	4%
595	Dementia, Vascular	4%
596	Myoclonic Epilepsy	4%
597	Epilepsy, Temporal Lobe	4%
598	Epilepsy, Rolandic	4%
599	Benign Rolandic Epilepsy	4%
600	Brain Hemorrhage, Traumatic	4%
601	Uveomeningoencephalitic Syndrome	4%
602	Sturge-Weber Syndrome	4%
603	Fetal Hypoxia	4%
604	Alcohol-Induced Disorders, Nervous System	4%
605	Tuberous Sclerosis	4%
606	Dyspnea, Paroxysmal	3.9%
607	Friedreich Ataxia	3.9%
608	Creutzfeldt-Jakob disease	3.9%
609	Urinary Incontinence	3.9%
610	Basal Ganglia Cerebrovascular Disease	3.9%
611	Brain Injuries, Diffuse	3.9%
612	Traumatic Brain Injury	3.9%
613	Albuminuria	3.9%
614	Hemoglobinuria	3.9%
615	Supratentorial Neoplasms	3.9%
616	Multiple Sclerosis, Chronic Progressive	3.9%
617	Multiple Sclerosis, Relapsing-Remitting	3.9%
618	Myotonia Congenita	3.8%
619	Paraneoplastic Cerebellar Degeneration	3.8%
620	Thrombocytopenic purpura	3.8%
621	Neuritis, Autoimmune, Experimental	3.8%
622	Waterhouse-Friderichsen Syndrome	3.7%
623	Hematoma, Subdural	3.7%
624	Hematoma, Epidural, Cranial	3.7%
625	Purpura, Hyperglobulinemic	3.7%
626	Hyperemesis Gravidarum	3.7%
627	Tuberculosis, Meningeal	3.7%
628	Carotid Artery Injuries	3.7%
629	Juvenile Myoclonic Epilepsy	3.6%
630	Myoclonic Epilepsies, Progressive	3.6%
631	Carpal Tunnel Syndrome	3.6%
632	Vascular Headaches	3.6%
633	neurofibroma	3.6%
634	Hypoxia-Ischemia, Brain	3.6%
635	Basal Ganglia Hemorrhage	3.5%
636	Genomic Instability	3.5%
637	Fragile X Syndrome	3.5%
638	Myotonic Dystrophy	3.5%
639	Hepatolenticular Degeneration	3.4%
640	Brain Diseases, Metabolic	3.4%
641	Cerebrovascular Disorders	3.4%
642	Myositis	3.4%
643	Optic Atrophy	3.4%
644	Optic Neuritis	3.4%
645	Papilledema	3.4%
646	Strabismus	3.4%
647	Tolosa-Hunt Syndrome	3.4%
648	Cerebrovascular Insufficiency	3.4%
649	Isaacs syndrome	3.4%
650	Arsenic Poisoning	3.4%
651	Dementia	3.4%
652	Myotonic Disorders	3.4%
653	Central Nervous System Fungal Infections	3.4%
654	Conus Medullaris Syndrome	3.4%
655	Myasthenic Syndromes, Congenital	3.4%
656	Spinal Cord Vascular Diseases	3.4%
657	Adrenoleukodystrophy	3.4%
658	Smith-Magenis syndrome	3.4%
659	Dural Arteriovenous Fistula	3.3%
660	Chromosomal Instability	3.3%
661	Diverticulum	3.3%
662	Diverticulosis	3.3%
663	Diabetic Neuropathies	3.3%
664	Facial Injuries	3.3%
665	Facial Neuralgia	3.3%
666	Diabetic Amyotrophy	3.3%
667	Diabetic Autonomic Neuropathy	3.3%
668	Sleep Talking	3.3%
669	Manganese Poisoning	3.3%
670	Sleep Disorders, Intrinsic	3.3%
671	Azotemia	3.3%
672	Acute Disease	3.3%
673	Acute-Phase Reaction	3.3%
674	Amenorrhea	3.3%
675	Chronic disease	3.3%
676	Critical Illness	3.3%
677	Sudden death	3.3%
678	Fat necrosis	3.3%
679	Gangrene	3.3%
680	Graft Occlusion, Vascular	3.3%
681	Granuloma, Plasma Cell	3.3%
682	Hematoma	3.3%
683	Diaphragmatic Hernia	3.3%
684	Hydrops Fetalis	3.3%
685	Iatrogenic Disease	3.3%
686	Intestinal Polyps	3.3%
687	Multiple Organ Failure	3.3%
688	Oligomenorrhea	3.3%
689	Premenstrual syndrome	3.3%
690	Recurrence	3.3%
691	Retrograde Degeneration	3.3%
692	Retroperitoneal fibrosis	3.3%
693	Serositis	3.3%
694	Splenomegaly	3.3%
695	Subcutaneous Emphysema	3.3%
696	Surgical Wound Dehiscence	3.3%
697	Syndrome	3.3%
698	Wallerian Degeneration	3.3%
699	Pyogenic granuloma	3.3%
700	Exsanguination	3.3%
701	Disease Progression	3.3%
702	Seroma	3.3%
703	Premenstrual Tension	3.3%
704	Delayed Emergence from Anesthesia	3.3%
705	Infant Death	3.3%
706	Anastomotic Leak	3.3%
707	Intraoperative Awareness	3.3%
708	Rubinstein-Taybi Syndrome	3.3%
709	Leukomalacia, Periventricular	3.3%
710	Meningeal Neoplasms	3.3%
711	Meningomyelocele	3.3%
712	Spina Bifida	3.3%
713	Mercury Poisoning, Nervous System	3.3%
714	Lead Poisoning, Nervous System	3.3%
715	Vestibular Neuronitis	3.3%
716	Cerebral Palsy	3.3%
717	Epilepsies, Partial	3.3%
718	Epilepsy, Generalized	3.3%
719	Pseudotumor Cerebri	3.3%
720	Sciatic Neuropathy	3.3%
721	Hypertensive Encephalopathy	3.3%
722	Ulnar Neuropathies	3.3%
723	Lesion of Sciatic Nerve	3.3%
724	Simple Partial Seizures	3.3%
725	Epilepsy, Reflex	3.3%
726	Ulnar Neuritis	3.3%
727	Radial nerve compression	3.3%
728	Radial Tunnel Syndrome	3.3%
729	Peroneal Neuropathies	3.3%
730	Radial Neuropathy	3.3%
731	Median Neuropathy	3.3%
732	Sciatic Nerve Palsy	3.3%
733	Femoral Neuropathy	3.3%
734	Tibial Neuropathy	3.3%
735	Ulnar Nerve Palsy	3.3%
736	Postural Orthostatic Tachycardia Syndrome	3.3%
737	Radial nerve palsy	3.3%
738	Headache Disorders, Primary	3.3%
739	Headache Disorders, Secondary	3.3%
740	Medication overuse headache	3.3%
741	Menorrhagia	3.3%
742	Sudden infant death syndrome	3.3%
743	Fetal Weight	3.3%
744	Brain Concussion	3.2%
745	Obesity	3.2%
746	Cubital Tunnel Syndrome	3.2%
747	Diffuse Axonal Injury	3.2%
748	Brain Stem Neoplasms	3.2%
749	Putaminal Hemorrhage	3.1%
750	Pituitary Adenoma	3.1%
751	Pituitary Neoplasms	3.1%
752	Optic Nerve Glioma	3.1%
753	Toxoplasmosis, Cerebral	3.1%
754	Hematoma, Subdural, Intracranial	3%
755	Hematoma, Subdural, Chronic	3%
756	Hematoma, Subdural, Acute	3%
757	Vertebral Artery Dissection	3%
758	Refsum Disease	3%
759	Meningitis, Cryptococcal	3%
760	Meningitis, Listeria	3%
761	Meningitis, Haemophilus	3%
762	Meningitis, Pneumococcal	3%
763	Frontotemporal dementia	3%
764	Subarachnoid Hemorrhage	2.9%
765	Cerebral Hemorrhage	2.9%
766	Urge Incontinence	2.9%
767	Choroid Plexus Papilloma	2.9%
768	Cardiotoxicity	2.8%
769	Alstrom Syndrome	2.8%
770	Mitochondrial Encephalomyopathies	2.8%
771	Hand-Arm Vibration Syndrome	2.8%
772	Tinea Pedis	2.8%
773	Purpura, Thrombotic Thrombocytopenic	2.8%
774	Pituitary Apoplexy	2.7%
775	Fibromyalgia	2.7%
776	Optic Neuropathy, Ischemic	2.7%
777	Anterior Ischemic Optic Neuropathy	2.7%
778	Central Nervous System Bacterial Infections	2.7%
779	Medial Tibial Stress Syndrome	2.7%
780	Polyradiculopathy	2.7%
781	Post-Traumatic Headache	2.7%
782	Tension Headache	2.7%
783	Epilepsy, Complex Partial	2.7%
784	Migraine Disorders	2.7%
785	Abdominal Migraine	2.7%
786	Status Migrainosus	2.7%
787	Cervicogenic Headache	2.7%
788	Menkes Kinky Hair Syndrome	2.7%
789	Brain Contusion	2.7%
790	Brain Infarction	2.7%
791	Facial Hemiatrophy	2.7%
792	Melkersson-Rosenthal Syndrome	2.7%
793	Mitochondrial Myopathies	2.7%
794	Subarachnoid Hemorrhage, Traumatic	2.7%
795	Carotid Artery, Internal, Dissection	2.7%
796	Eosinophilia-Myalgia Syndrome	2.7%
797	Subacute Sclerosing Panencephalitis	2.7%
798	Sleep Bruxism	2.6%
799	Anencephaly	2.6%
800	Asphyxia	2.6%
801	Granuloma, Respiratory Tract	2.6%
802	Shock, Traumatic	2.6%
803	Respiratory Tract Fistula	2.6%
804	Pituitary Diseases	2.6%
805	Infarction, Middle Cerebral Artery	2.6%
806	Infarction, Anterior Cerebral Artery	2.6%
807	Infarction, Posterior Cerebral Artery	2.6%
808	Amyloid Neuropathies, Familial	2.5%
809	Classical Lissencephalies and Subcortical Band Heterotopias	2.5%
810	Disease susceptibility	2.5%
811	Fetal Death	2.5%
812	Foreign-Body Reaction	2.5%
813	Gastrointestinal Hemorrhage	2.5%
814	Cardiomegaly	2.5%
815	Hemarthrosis	2.5%
816	Hemoperitoneum	2.5%
817	Hemothorax	2.5%
818	Hepatomegaly	2.5%
819	Neoplasm Invasiveness	2.5%
820	Neoplasm Metastasis	2.5%
821	Neoplasm Recurrence, Local	2.5%
822	Parovarian Cyst	2.5%
823	Postpericardiotomy Syndrome	2.5%
824	Prosthesis Failure	2.5%
825	Reperfusion Injury	2.5%
826	Spermatocele	2.5%
827	Oral Fistula	2.5%
828	Injection Site Reaction	2.5%
829	Retrobulbar Hemorrhage	2.5%
830	Cutaneous Fistula	2.5%
831	Aseptic Necrosis of Bone	2.5%
832	Peritoneal Fibrosis	2.5%
833	Carcinogenesis	2.5%
834	Perinatal death	2.5%
835	Infusion site reaction	2.5%
836	Cardiac Hypertrophy	2.5%
837	Nephrogenic Fibrosing Dermopathy	2.5%
838	Corneal Endothelial Cell Loss	2.5%
839	Encapsulating Peritoneal Sclerosis	2.5%
840	Vasoplegia	2.5%
841	Suppuration	2.5%
842	Nephrogenic Systemic Fibrosis	2.5%
843	Metastasis	2.5%
844	Kernicterus	2.5%
845	Thoracic Outlet Syndrome	2.5%
846	Sinus Arrhythmia	2.5%
847	Atrial Fibrillation	2.5%
848	Atrial Flutter	2.5%
849	Dental Pulp Necrosis	2.5%
850	Granuloma, Foreign-Body	2.5%
851	Mediastinal Emphysema	2.5%
852	Surgical Wound Infection	2.5%
853	Ventricular Fibrillation	2.5%
854	Ventricular Flutter	2.5%
855	Parasystole	2.5%
856	Paroxysmal atrial fibrillation	2.5%
857	Facies	2.5%
858	Bradycardia	2.5%
859	Embryo Loss	2.5%
860	Afferent Loop Syndrome	2.5%
861	Carotid Artery Diseases	2.5%
862	Brain Ischemia	2.5%
863	Esotropia	2.5%
864	Exotropia	2.5%
865	Hypotension, Orthostatic	2.5%
866	Sex Chromosome Aberrations	2.5%
867	Short Bowel Syndrome	2.5%
868	Sleep Apnea Syndromes	2.5%
869	Cerebrovascular accident	2.5%
870	Uterine hemorrhage	2.5%
871	Vaginal Fistula	2.5%
872	Polymyositis	2.5%
873	Rectocele	2.5%
874	No-Reflow Phenomenon	2.5%
875	Kluver-Bucy Syndrome	2.5%
876	Vasospasm, Intracranial	2.5%
877	Spinal Cord Ischemia	2.5%
878	Intracranial Arterial Diseases	2.5%
879	Post-Exercise Hypotension	2.5%
880	Disorders of Excessive Somnolence	2.4%
881	Sleep Initiation and Maintenance Disorders	2.4%
882	Night Terrors	2.4%
883	Somnambulism	2.4%
884	Trigeminal Nerve Disorder	2.4%
885	Transient Insomnia	2.4%
886	Sleep Paralysis	2.4%
887	Chronic Insomnia	2.4%
888	REM Sleep Behavior Disorder	2.4%
889	Hypersomnia	2.4%
890	Dermal Sinus	2.4%
891	Spina Bifida Cystica	2.4%
892	Spina Bifida Occulta	2.4%
893	Meningeal Carcinomatosis	2.4%
894	Lissencephaly	2.4%
895	Polymicrogyria	2.4%
896	Pachygyria	2.4%
897	Schizencephaly	2.4%
898	Lead Poisoning, Nervous System, Childhood	2.4%
899	Lead Poisoning, Nervous System, Adult	2.4%
900	Periventricular Nodular Heterotopia	2.4%
901	Cluster Headache	2.4%
902	Migraine with Aura	2.4%
903	Familial Hemiplegic Migraine	2.4%
904	Chronic Paroxysmal Hemicrania	2.4%
905	SUNCT Syndrome	2.4%
906	Paroxysmal Hemicrania	2.4%
907	Tuberculosis, Central Nervous System	2.4%
908	Mucopolysaccharidosis II	2.4%
909	Pediatric Obesity	2.4%
910	Cerebral Infarction	2.4%
911	Brain Stem Infarctions	2.4%
912	Acoustic Neuroma	2.4%
913	Giant Cell Arteritis	2.4%
914	Temporal Arteritis	2.4%
915	Endotoxic shock	2.3%
916	Septic Shock	2.3%
917	Toxic Shock Syndrome	2.3%
918	Duane Retraction Syndrome	2.3%
919	Lateral Medullary Syndrome	2.3%
920	Mobius Syndrome	2.2%
921	Bell Palsy	2.2%
922	Herpes Zoster Oticus	2.2%
923	Familial Periodic Paralysis	2.2%
924	Autoimmune thrombocytopenia	2.2%
925	Immune thrombocytopenic purpura	2.2%
926	MELAS Syndrome	2.2%
927	Moyamoya Disease	2.2%
928	Tissue Adhesions	2.2%
929	Colonic Polyps	2.2%
930	Hematoma, Epidural, Spinal	2.2%
931	Neurofibrosarcoma	2.2%
932	Chromosome Fragility	2.2%
933	West Nile Fever	2.1%
934	Empty Sella Syndrome	2.1%
935	Hyperpituitarism	2.1%
936	Hypopituitarism	2.1%
937	Hypophysitis	2.1%
938	Drowning	2.1%
939	Eye Injuries	2%
940	Nasal Polyps	2%
941	Cerebral Arterial Diseases	2%
942	Vertebrobasilar Insufficiency	2%
943	Anterior Spinal Artery Syndrome	2%
944	Basilar Artery Stenosis	2%
945	Vertebral Artery Stenosis	2%
946	Sleep Apnea, Obstructive	2%
947	Sleep Apnea, Central	2%
948	Intracranial Hemorrhage, Hypertensive	2%
949	Transient Cerebral Ischemia	2%
950	Narcolepsy	2%
951	Trigeminal Neuralgia	2%
952	Kleine-Levin Syndrome	2%
953	Fetal Growth Retardation	2%
954	DNA Degradation, Necrotic	2%
955	Aneuploidy	2%
956	Muscular Dystrophy	2%
957	Polyploidy	2%
958	Congenital nystagmus	2%
959	Microsatellite Instability	2%
960	Orbital Myositis	2%
961	Optic Atrophy, Hereditary, Leber	2%
962	Heart Block	2%
963	Tachycardia	2%
964	Tachyarrhythmia	2%
965	Cicatrix	2%
966	Hematuria	2%
967	Reye Syndrome	2%
968	Urinary Calculi	2%
969	Granuloma Annulare	2%
970	Chromosome Breakage	2%
971	Neuroaspergillosis	2%
972	Pyomyositis	2%
973	Intracranial Embolism and Thrombosis	2%
974	Hepatic Encephalopathy	2%
975	Shock, Cardiogenic	2%
976	Neuronal Ceroid-Lipofuscinoses	1.9%
977	Sick Sinus Syndrome	1.9%
978	Trisomy	1.9%
979	Hyperprolactinemia	1.8%
980	Subclavian Steal Syndrome	1.8%
981	Pick Disease of the Brain	1.8%
982	Cataplexy	1.8%
983	Pseudorabies	1.7%
984	Giant Cell Epulis	1.7%
985	Aicardi's syndrome	1.7%
986	Biliary Fistula	1.7%
987	Cross Infection	1.7%
988	Gastric Fistula	1.7%
989	Hyphema	1.7%
990	Retinal Neovascularization	1.7%
991	Septicemia	1.7%
992	Vitreous Hemorrhage	1.7%
993	Congenital diaphragmatic hernia	1.7%
994	Sepsis	1.7%
995	Cockayne Syndrome	1.7%
996	Toxoplasmosis, Congenital	1.7%
997	Leukoplakia, Oral	1.6%
998	Long QT Syndrome	1.6%
999	Brain Diseases, Metabolic, Inborn	1.6%
1000	Eye Burns	1.6%
1001	Alcohol Withdrawal Delirium	1.6%
1002	Abscess	1.6%
1003	Dental Fistula	1.6%
1004	Empyema	1.6%
1005	Femur Head Necrosis	1.6%
1006	Fetal Resorption	1.6%
1007	Lymphatic Metastasis	1.6%
1008	Malaria, Cerebral	1.6%
1009	Neoplasms, Unknown Primary	1.6%
1010	Oroantral Fistula	1.6%
1011	Peptic Ulcer Hemorrhage	1.6%
1012	Sudden Cardiac Death	1.6%
1013	POEMS Syndrome	1.6%
1014	Left Ventricular Hypertrophy	1.6%
1015	Leukemic Infiltration	1.6%
1016	Right Ventricular Hypertrophy	1.6%
1017	Premenstrual Dysphoric Disorder	1.6%
1018	Choroidal Neovascularization	1.6%
1019	Primary Graft Dysfunction	1.6%
1020	Neoplasm Micrometastasis	1.6%
1021	Meningioma	1.6%
1022	Carotid Stenosis	1.6%
1023	Intracranial Aneurysm	1.6%
1024	Welander Distal Myopathy	1.6%
1025	Dumping Syndrome	1.6%
1026	Microcephaly	1.6%
1027	Rectal Prolapse	1.6%
1028	Uterine Prolapse	1.6%
1029	Cicatrix, Hypertrophic	1.6%
1030	Vaginal Prolapse	1.6%
1031	Macrocephaly	1.6%
1032	Sinus Arrest, Cardiac	1.6%
1033	Neurocysticercosis	1.6%
1034	Micronuclei, Chromosome-Defective	1.6%
1035	Neurosyphilis	1.6%
1036	Hypokalemic periodic paralysis	1.6%
1037	Hematoma, Subdural, Spinal	1.6%
1038	Metrorrhagia	1.6%
1039	Intracranial Arteriosclerosis	1.6%
1040	Cerebral Atherosclerosis	1.6%
1041	Cerebral Arteriosclerosis	1.6%
1042	Cerebral Thrombosis	1.6%
1043	Intracranial Embolism	1.6%
1044	Intracranial Thrombosis	1.6%
1045	Porencephaly	1.6%
1046	Vesicovaginal Fistula	1.6%
1047	Acromegaly	1.5%
1048	Holoprosencephaly	1.5%
1049	Cerebral Amyloid Angiopathy	1.4%
1050	Sinus Thrombosis, Intracranial	1.4%
1051	Eosinophilic Granuloma	1.4%
1052	Wernicke Encephalopathy	1.4%
1053	AIDS Dementia Complex	1.4%
1054	Dermatomyositis	1.4%
1055	Corneal Scar	1.4%
1056	Lyme Neuroborreliosis	1.4%
1057	Muscular Dystrophy, Duchenne	1.4%
1058	Cavernous Sinus Thrombosis	1.4%
1059	Sagittal Sinus Thrombosis	1.4%
1060	Bronchial Fistula	1.4%
1061	Pancreatic Fistula	1.4%
1062	Retinal Hemorrhage	1.4%
1063	Carotid Artery Thrombosis	1.3%
1064	Choroid Hemorrhage	1.3%
1065	Intestinal Fistula	1.3%
1066	Melena	1.3%
1067	Gastroschisis	1.3%
1068	Enterocutaneous Fistula	1.3%
1069	Postpartum Hemorrhage	1.3%
1070	Salivary Gland Fistula	1.3%
1071	Cystocele	1.3%
1072	Gingival Hemorrhage	1.3%
1073	Keloid	1.3%
1074	Monosomy	1.3%
1075	Tetraploidy	1.3%
1076	Stillbirth	1.3%
1077	Adams-Stokes Syndrome	1.3%
1078	Atrioventricular Block	1.3%
1079	Bundle-Branch Block	1.3%
1080	Atrial Premature Complexes	1.3%
1081	Sinoatrial Block	1.3%
1082	Tachycardia, Paroxysmal	1.3%
1083	Supraventricular tachycardia	1.3%
1084	Tachycardia, Ventricular	1.3%
1085	Tachycardia, Reciprocating	1.3%
1086	Viremia	1.3%
1087	Parasitemia	1.3%
1088	Umbilical hernia	1.2%
1089	Corneal Perforation	1.2%
1090	Nelson Syndrome	1.1%
1091	Cellulitis	1.1%
1092	Romano-Ward Syndrome	1.1%
1093	Fabry Disease	1.1%
1094	Prolactinoma	1%
1095	Growth Hormone-Secreting Pituitary Adenoma	1%
1096	Galactosemias	1%
1097	Urea Cycle Disorders, Inborn	1%
1098	Tyrosinemias	1%
1099	Bacteremia	1%
1100	Cell Transformation, Viral	1%
1101	Fungemia	1%
1102	Granuloma, Laryngeal	1%
1103	Tachycardia, Atrioventricular Nodal Reentry	1%
1104	Tachycardia, Ectopic Atrial	1%
1105	Tachycardia, Ectopic Junctional	1%
1106	Sinus Tachycardia	1%
1107	Torsades de Pointes	1%
1108	Accelerated Idioventricular Rhythm	1%
1109	Myocardial Reperfusion Injury	0.9%
1110	Urinary Bladder Fistula	0.9%
1111	Homocystinuria	0.9%
1112	Leigh Disease	0.9%
1113	Arteriovenous fistula	0.8%
1114	Rectal Fistula	0.8%
1115	Anal Fistula	0.8%
1116	Endotoxemia	0.8%
1117	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
1118	Philadelphia Chromosome	0.8%
1119	Glycogen storage disease type II	0.7%
1120	Kidney Calculi	0.7%
1121	Ureteral Calculi	0.7%
1122	Zellweger Syndrome	0.7%
1123	Gaucher Disease	0.6%
1124	Tay-Sachs Disease	0.6%
1125	Candidemia	0.6%
1126	Niemann-Pick Disease, Type C	0.5%

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