MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tyrosinemias

(UMLS:C0268483)

Definition:: A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)
UMLS ID:: C0268483
MeSH ID:: D020176

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.875

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.100.880|C16.320.565.189.875

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.875|C18.452.648.100.880|C18.452.648.189.875

Synonym(s)

Tyrosinemias

Tyrosinaemia

Tyrosinemia

hereditary tyrosinemia

tyrosinaemia

tyrosinemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aminolevulinic Acid	18665889	CTD
2	Carbamazepine	3313115	CTD
3	nitisinone	11488774 12899938	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Urea Cycle Disorders, Inborn	70%
2	Galactosemias	61.4%
3	Leigh Disease	59.5%
4	Homocystinuria	59.1%
5	Adrenoleukodystrophy	56.8%
6	Carbamoyl-Phosphate Synthase I Deficiency Disease	54.9%
7	Hepatolenticular Degeneration	51.2%
8	Menkes Kinky Hair Syndrome	51.2%
9	Glycogen storage disease type II	49.7%
10	Zellweger Syndrome	47.8%
11	Refsum Disease	47.4%
12	Gaucher Disease	41.4%
13	MELAS Syndrome	40.3%
14	Hyperhomocysteinemia	40.2%
15	Smith-Lemli-Opitz Syndrome	39.8%
16	Fabry Disease	39%
17	Alkaptonuria	37.8%
18	Propionic acidemia	37.8%
19	Carbohydrate Metabolism, Inborn Errors	37.7%
20	Metal Metabolism, Inborn Errors	37.7%
21	Progeria	37.7%
22	Lysosomal Storage Diseases	37.7%
23	Peroxisomal Disorders	37.7%
24	Canavan Disease	35.8%
25	Alexander Disease	35.8%
26	Hyperphosphaturia	35.1%
27	Tay-Sachs Disease	34.8%
28	Niemann-Pick Disease, Type C	34.7%
29	Pseudohypoparathyroidism	34.3%
30	Albinism	32.7%
31	Lactose Intolerance	28.8%
32	Hypolipoproteinemias	28.6%
33	Cytochrome-c Oxidase Deficiency	28%
34	Amyloid Neuropathies, Familial	27.6%
35	Hyperlipoproteinemia Type IV	27.1%
36	Hyperlipoproteinemia Type V	27.1%
37	Mucopolysaccharidosis III	27.1%
38	Mucopolysaccharidosis II	27%
39	Hyperlipidemia, Familial Combined	27%
40	Familial Hypophosphatemic Rickets	26.6%
41	Hyperlipoproteinemia Type III	26.1%
42	Neuronal Ceroid-Lipofuscinoses	25%
43	Glycogen Storage Disease	24.9%
44	Hypophosphatasia	24.9%
45	Dihydropyrimidine Dehydrogenase Deficiency	24.9%
46	Cystinosis	24.9%
47	Wasting Syndrome	24.7%
48	Myelinolysis, Central Pontine	24%
49	Mitochondrial Encephalomyopathies	23.9%
50	Ichthyosis, X-Linked	23.4%
51	Renal tubular acidosis	23.4%
52	Werner Syndrome	23.3%
53	Brain Diseases, Metabolic, Inborn	22.4%
54	Reye Syndrome	22.2%
55	Hepatic Encephalopathy	22.1%
56	Hypercalcemia	21.9%
57	Hypocalcemia	21.9%
58	Milk-Alkali Syndrome	21.9%
59	Tyrosinemias	21.4%
60	Hypoalphalipoproteinemias	21.4%
61	Familial Periodic Paralysis	21%
62	Acid-Base Imbalance	21%
63	Calcium Metabolism Disorders	21%
64	Iron Metabolism Disorders	21%
65	Phosphorus Metabolism Disorders	21%
66	Water-Electrolyte Imbalance	21%
67	Lipid Metabolism Disorders	21%
68	Mitochondrial Diseases	21%
69	Glucose Metabolism Disorders	21%
70	Amino Acid Metabolism, Inborn Errors	20.7%
71	Sjogren-Larsson Syndrome	20%
72	Renal Aminoacidurias	19.9%
73	Fanconi Syndrome	19.9%
74	Pseudohypoaldosteronism	19.9%
75	Liddle Syndrome	19.9%
76	Glycosuria, Renal	19.8%
77	Lipodystrophy	19.5%
78	Cockayne Syndrome	19.5%
79	Antley-Bixler Syndrome Phenotype	19.4%
80	Wernicke Encephalopathy	19.1%
81	Rickets	18.7%
82	Glycogen Storage Disease Type I	18.6%
83	Glycogen Storage Disease Type V	18.6%
84	Osteopenia	18.6%
85	Kernicterus	18.5%
86	Gout	18.4%
87	Ataxia Telangiectasia	17.1%
88	Hypokalemic periodic paralysis	15.5%
89	Friedreich Ataxia	15.2%
90	Congenital Hyperinsulinism	15.1%
91	Cystinuria	14.9%
92	Porphyrias, Hepatic	14.8%
93	Fanconi Anemia	14.5%
94	Aicardi's syndrome	14.4%
95	Arthritis, Gouty	13.6%
96	Cystic Fibrosis	13.4%
97	Bloom Syndrome	13.4%
98	Optic Atrophy, Hereditary, Leber	13.3%
99	Myasthenic Syndromes, Congenital	13.3%
100	CHARGE Syndrome	13.1%
101	Nutrition Disorders	12.8%
102	Osteomalacia	12.6%
103	Neoplastic Syndromes, Hereditary	12.6%
104	Acidosis	12.5%
105	Alkalosis	12.5%
106	Amyloidosis	12.5%
107	Calcinosis	12.5%
108	Hyperglycemia	12.5%
109	Hyperinsulinism	12.5%
110	Hyperkalemia	12.5%
111	Hypernatremia	12.5%
112	Hypoglycemia	12.5%
113	Hypokalemia	12.5%
114	Hyponatremia	12.5%
115	Xanthomatosis	12.5%
116	Hypophosphatemia	12.5%
117	Metabolic acidosis	12.5%
118	Dyslipidemias	12.5%
119	Iron Overload	12.5%
120	Xanthoma	12.5%
121	Brain Diseases, Metabolic	12.3%
122	Multiple Epiphyseal Dysplasia	12.3%
123	Osteochondrodysplasias	12.3%
124	Pelger-Huet Anomaly	12.3%
125	Xeroderma Pigmentosum	12%
126	Fragile X Syndrome	12%
127	Muscular Dystrophy, Duchenne	12%
128	Nail-Patella Syndrome	11.9%
129	Alstrom Syndrome	11.9%
130	Anemia, Sickle Cell	11.7%
131	Thalassemia	11.7%
132	Dystonia Musculorum Deformans	11.5%
133	Muscular Dystrophy	11.4%
134	Smith-Magenis syndrome	11.3%
135	Diabetic Ketoacidosis	11.3%
136	Diabetes Mellitus	11.2%
137	Dwarfism	11.2%
138	Huntington Disease	11.1%
139	Prader-Willi Syndrome	11.1%
140	Dehydration	11%
141	Lipomatosis	11%
142	Water Intoxication	11%
143	Marchiafava-Bignami Disease	11%
144	Achlorhydria	11%
145	Osteoporosis	11%
146	Bone Demineralization, Pathologic	11%
147	Post-Traumatic Osteoporosis	11%
148	Celiac Disease	10.9%
149	Sprue, Tropical	10.9%
150	Steatorrhea	10.9%
151	Sprue	10.9%
152	Osteogenesis Imperfecta	10.9%
153	Beckwith-Wiedemann Syndrome	10.8%
154	Wolf-Hirschhorn Syndrome	10.8%
155	Mitochondrial Myopathies	10.7%
156	Nesidioblastosis	10.7%
157	Kartagener Syndrome	10.6%
158	HIV Wasting Syndrome	10.6%
159	Tuberous Sclerosis	10.5%
160	Dandy-Walker Syndrome	10.3%
161	Myotonic Dystrophy	10.2%
162	Cri-du-Chat Syndrome	10.2%
163	Down Syndrome	10.2%
164	Trisomy 21	10.2%
165	Marfan Syndrome	10.2%
166	Holoprosencephaly	10.2%
167	Autoimmune Lymphoproliferative Syndrome	9.9%
168	Amyotrophic Lateral Sclerosis	9.8%
169	Renal Osteodystrophy	9.8%
170	Renal rickets	9.8%
171	Angioedemas, Hereditary	9.8%
172	Wiskott-Aldrich Syndrome	9.8%
173	Glycosuria	9.7%
174	Meningoencephalitis	9.7%
175	Variegate Porphyria	9.7%
176	Acute intermittent porphyria	9.7%
177	Porphyria Cutanea Tarda	9.7%
178	HIV-Associated Lipodystrophy Syndrome	9.7%
179	Lafora Disease	9.4%
180	Unverricht-Lundborg Syndrome	9.4%
181	Dementia, Vascular	9.1%
182	Kallmann Syndrome	8.9%
183	Rett Syndrome	8.9%
184	Ectodermal Dysplasia	8.9%
185	Aplasia Cutis Congenita	8.9%
186	Subdural Effusion	8.9%
187	Rubinstein-Taybi Syndrome	8.9%
188	Necrobiosis Lipoidica Diabeticorum	8.8%
189	Leukomalacia, Periventricular	8.8%
190	Kearns-Sayre syndrome	8.7%
191	Encephalomyelitis	8.6%
192	Deformity	8.6%
193	Familial Mediterranean Fever	8.3%
194	Pneumocephalus	8.3%
195	Cerebral Amyloid Angiopathy	8.3%
196	Acidosis, Lactic	8.3%
197	Calciphylaxis	8.3%
198	Hemosiderosis	8.3%
199	Ketosis	8.3%
200	Ketonuria	8.3%
201	Ketoacidosis	8.3%
202	Ketonemia	8.3%
203	Vascular calcification	8.3%
204	Williams Syndrome	8.3%
205	Brain Abscess	8.2%
206	Multiple System Atrophy	8.2%
207	Akinetic Mutism	8.1%
208	Anoxic Encephalopathy	8.1%
209	Basal Ganglia Diseases	8.1%
210	Brain Damage, Chronic	8.1%
211	Cerebellar Diseases	8.1%
212	Encephalitis	8.1%
213	Encephalomalacia	8.1%
214	Epilepsy	8.1%
215	Hydrocephalus	8.1%
216	Congenital Hydrocephalus	8.1%
217	Hypothalamic Diseases	8.1%
218	Thalamic Diseases	8.1%
219	Intracranial Hypertension	8.1%
220	Aura	8.1%
221	Leukoencephalopathy	8.1%
222	Neuroaxonal Dystrophies	8.1%
223	Headache Disorders	8.1%
224	Intracranial Hypotension	8.1%
225	Brain Edema	8.1%
226	Brain Hypoxia	8.1%
227	Aqueductal Stenosis	8.1%
228	Lewy Body Disease	7.8%
229	Polycystic Kidney Diseases	7.8%
230	Sickle Cell Trait	7.7%
231	Fetal Diseases	7.5%
232	Basal Ganglia Cerebrovascular Disease	7.5%
233	Primary Ciliary Dyskinesia	7.4%
234	Tetany	7.4%
235	Acidosis, Respiratory	7.3%
236	Adiposis Dolorosa	7.3%
237	Alkalosis, Respiratory	7.3%
238	Parkinsonian Disorders	7.3%
239	Retinal Dysplasia	7.3%
240	Epilepsy, Post-Traumatic	7.2%
241	Insulin Resistance	7.2%
242	Osteoporosis, Postmenopausal	7.2%
243	Brain Injuries	7.2%
244	Aniridia	7.2%
245	Brain Neoplasms	7.2%
246	Cerebrovascular Disorders	7.2%
247	Cerebrovascular Insufficiency	7.2%
248	Dementia	7.2%
249	Myotonia Congenita	7.2%
250	Epidermolysis Bullosa	7.1%
251	Frontotemporal dementia	7.1%
252	Posterior Leukoencephalopathy Syndrome	7%
253	Posterior reversible encephalopathy syndrome	7%
254	Child Nutrition Disorders	7%
255	Hypervitaminosis A	7%
256	Infant Nutrition Disorders	7%
257	Malnutrition	7%
258	Welander Distal Myopathy	6.8%
259	Duane Retraction Syndrome	6.8%
260	Ocular Motility Disorders	6.8%
261	Cyclophoria	6.8%
262	Gestational Diabetes	6.6%
263	Latent Autoimmune Diabetes in Adults	6.6%
264	Brain Death	6.6%
265	Cutis Laxa	6.6%
266	Acute Chest Syndrome	6.5%
267	Diabetes Mellitus, Experimental	6.5%
268	Retinitis Pigmentosa	6.5%
269	Pigmentary retinopathy	6.5%
270	Porokeratosis	6.5%
271	Keratoderma, Palmoplantar	6.5%
272	Chronic granulomatous disease	6.5%
273	Nephrocalcinosis	6.5%
274	Epidural Abscess	6.3%
275	Meningitis	6.3%
276	Movement Disorders	6.3%
277	Pachymeningitis	6.3%
278	Spinal Cord Diseases	6.3%
279	Vascular Headaches	6.3%
280	Hypoxia-Ischemia, Brain	6.2%
281	Hypercholesterolemia	6.2%
282	Hyperlipoproteinemias	6.2%
283	Hypertriglyceridemia	6.2%
284	Amblyopia	6.2%
285	Charcot-Marie-Tooth Disease	6.2%
286	Myelitis	6.1%
287	Mobius Syndrome	6.1%
288	Pseudoxanthoma Elasticum	6.1%
289	Meconium Aspiration Syndrome	6.1%
290	Meige Syndrome	6%
291	Cerebral Ventriculitis	6%
292	Subacute Combined Degeneration	5.9%
293	Cerebellar Neoplasms	5.9%
294	Progressive supranuclear palsy	5.9%
295	Peutz-Jeghers Syndrome	5.9%
296	Thrombasthenia	5.9%
297	Primary amyloidosis	5.9%
298	Antithrombin III Deficiency	5.9%
299	Protein C Deficiency	5.9%
300	Afibrinogenemia	5.8%
301	Factor VII Deficiency	5.8%
302	Factor X Deficiency	5.8%
303	Factor XII Deficiency	5.8%
304	Hemophilia A	5.8%
305	Activated Protein C Resistance	5.8%
306	Factor II deficiency	5.8%
307	Factor VIII Deficiency	5.8%
308	Factor V deficiency	5.8%
309	Factor XI Deficiency	5.8%
310	Hypoprothrombinemias	5.8%
311	Classical Lissencephalies and Subcortical Band Heterotopias	5.8%
312	Anemia, Diamond-Blackfan	5.8%
313	Parkinson Disease	5.8%
314	Leukoencephalopathy, Progressive Multifocal	5.8%
315	Central Nervous System Infection	5.7%
316	Myoclonic Epilepsy	5.6%
317	Epilepsy, Temporal Lobe	5.6%
318	Epilepsy, Rolandic	5.6%
319	Benign Rolandic Epilepsy	5.6%
320	Stiff-Person Syndrome	5.5%
321	Multiple Endocrine Neoplasia	5.4%
322	Neuroleptic Malignant Syndrome	5.4%
323	Amnesia, Transient Global	5.4%
324	Lupus Vasculitis, Central Nervous System	5.4%
325	Creutzfeldt-Jakob disease	5.4%
326	Congenital Hypothyroidism	5.4%
327	Dermatitis, Atopic	5.3%
328	Xeroderma	5.3%
329	Basal Cell Nevus Syndrome	5.2%
330	Limbic Encephalitis	5.2%
331	Polycystic Kidney, Autosomal Dominant	5.1%
332	Basal Ganglia Hemorrhage	5.1%
333	Hyperkeratosis, Epidermolytic	5.1%
334	Striatonigral Degeneration	5%
335	Prion Diseases	4.9%
336	Behcet Syndrome	4.9%
337	CREST Syndrome	4.8%
338	Cerebral Palsy	4.8%
339	Epilepsies, Partial	4.8%
340	Epilepsy, Generalized	4.8%
341	Pseudotumor Cerebri	4.8%
342	Hypertensive Encephalopathy	4.8%
343	Simple Partial Seizures	4.8%
344	Epilepsy, Reflex	4.8%
345	Headache Disorders, Primary	4.8%
346	Headache Disorders, Secondary	4.8%
347	Medication overuse headache	4.8%
348	Dural Arteriovenous Fistula	4.7%
349	Toxoplasmosis, Congenital	4.7%
350	Presenile dementia	4.7%
351	Senile dementia	4.7%
352	Leukoencephalitis, Acute Hemorrhagic	4.7%
353	Abdominal Cramps	4.7%
354	Abnormalities, Drug-Induced	4.7%
355	Amniotic Band Syndrome	4.7%
356	Asphyxia Neonatorum	4.7%
357	Infant, Premature, Diseases	4.7%
358	Situs Inversus	4.7%
359	Infantile Colic	4.7%
360	Pituitary Adenoma	4.6%
361	Pituitary Neoplasms	4.6%
362	Brain Hemorrhage, Traumatic	4.6%
363	Shy-Drager Syndrome	4.6%
364	Pituitary Apoplexy	4.5%
365	Spinal Muscular Atrophy	4.5%
366	Progressive Muscular Atrophy	4.5%
367	Anencephaly	4.5%
368	Brain Infarction	4.5%
369	Toxoplasmosis, Cerebral	4.5%
370	Vasculitis, Central Nervous System	4.5%
371	Spinal Cord Injuries	4.5%
372	Carotid Artery Injuries	4.4%
373	Poliomyelitis	4.4%
374	Asterixis	4.4%
375	Ballismus	4.4%
376	Pituitary Diseases	4.3%
377	Ophthalmoplegic Migraine	4.3%
378	Meningitis, Bacterial	4.3%
379	Meningitis, Fungal	4.3%
380	Hydranencephaly	4.3%
381	Neural Tube Defects	4.3%
382	Tethered Cord Syndrome	4.3%
383	Iniencephaly	4.3%
384	Craniorachischisis	4.3%
385	Exencephaly	4.3%
386	Septo-Optic Dysplasia	4.3%
387	Cortical Dysplasia	4.3%
388	Malformations of Cortical Development	4.3%
389	Papillon-Lefevre Disease	4.3%
390	Brain Injuries, Diffuse	4.3%
391	Traumatic Brain Injury	4.3%
392	Cerebellar Ataxia	4.3%
393	Supratentorial Neoplasms	4.3%
394	Central Nervous System Cysts	4.3%
395	Carotid Artery Diseases	4.2%
396	Brain Ischemia	4.2%
397	Cerebrovascular accident	4.2%
398	Kluver-Bucy Syndrome	4.2%
399	Vasospasm, Intracranial	4.2%
400	Intracranial Arterial Diseases	4.2%
401	Miller Fisher Syndrome	4.2%
402	Paraneoplastic Cerebellar Degeneration	4.2%
403	Juvenile Myoclonic Epilepsy	4.2%
404	Myoclonic Epilepsies, Progressive	4.2%
405	Eye Abnormalities	4.2%
406	Cardiovascular Abnormalities	4.2%
407	Nephroblastoma	4.2%
408	Congenital nystagmus	4.2%
409	Deficiency Diseases	4.2%
410	Starvation	4.2%
411	Refeeding Syndrome	4.2%
412	MPTP Poisoning	4.1%
413	Skin Abnormalities	4.1%
414	Lymphatic Abnormalities	4.1%
415	Congenital Microtia	4.1%
416	Persistent Vegetative State	4.1%
417	Anemia, Neonatal	4.1%
418	Persistent Fetal Circulation Syndrome	4.1%
419	Congenital diaphragmatic hernia	4.1%
420	Umbilical hernia	4.1%
421	Chronic Fatigue Syndrome	4%
422	Cranial nerve diseases	4%
423	Demyelinating Diseases	4%
424	Demyelination	4%
425	Neuromuscular Diseases	4%
426	Chronobiology Disorders	4%
427	Putaminal Hemorrhage	3.9%
428	Encephalomyelitis, Acute Disseminated	3.9%
429	Adenomatous Polyposis Coli	3.9%
430	Myelitis, Transverse	3.8%
431	Intracranial Embolism and Thrombosis	3.8%
432	Hydrops Fetalis	3.8%
433	Restless Legs Syndrome	3.8%
434	Urogenital Abnormalities	3.8%
435	Turner Syndrome	3.7%
436	Infarction, Middle Cerebral Artery	3.7%
437	Infarction, Anterior Cerebral Artery	3.7%
438	Infarction, Posterior Cerebral Artery	3.7%
439	Motor Neuron Disease	3.7%
440	Klinefelter Syndrome	3.7%
441	Neonatal Abstinence Syndrome	3.7%
442	Fetal Growth Retardation	3.6%
443	Fetal Hypoxia	3.6%
444	Fetal Alcohol Spectrum Disorders	3.6%
445	Trauma, Nervous System	3.6%
446	Spinal Cord Neoplasms	3.6%
447	Syphilis, Congenital	3.6%
448	Akathisia, Drug-Induced	3.6%
449	Moyamoya Disease	3.6%
450	Nervous System Neoplasms	3.6%
451	Neurologic Manifestations	3.6%
452	Neurotoxicity Syndromes	3.6%
453	Multiple Endocrine Neoplasia Type 1	3.5%
454	Opsoclonus-Myoclonus Syndrome	3.5%
455	Arachnoiditis	3.5%
456	Aseptic Meningitis	3.5%
457	Syringomyelia	3.5%
458	Essential Tremor	3.5%
459	Familial Tremor	3.5%
460	Pneumorrhachis	3.5%
461	Writer's Cramp	3.5%
462	Polyradiculoneuropathy	3.5%
463	Polyradiculoneuritis	3.5%
464	Cerebral Infarction	3.4%
465	Brain Stem Infarctions	3.4%
466	Chorioamnionitis	3.3%
467	Maxillofacial Abnormalities	3.3%
468	Dextrocardia	3.3%
469	Auditory Perceptual Disorders	3.2%
470	Sleep Wake Disorders	3.2%
471	Post-Traumatic Headache	3.2%
472	Tension Headache	3.2%
473	Epilepsy, Complex Partial	3.2%
474	Migraine Disorders	3.2%
475	Abdominal Migraine	3.2%
476	Status Migrainosus	3.2%
477	Cervicogenic Headache	3.2%
478	Dyskinesia, Drug-Induced	3.2%
479	AIDS Dementia Complex	3.1%
480	Central Nervous System Fungal Infections	3.1%
481	Conus Medullaris Syndrome	3.1%
482	Spinal Cord Vascular Diseases	3.1%
483	Tuberculosis, Meningeal	3.1%
484	Abnormalities, Radiation-Induced	3%
485	Subarachnoid Hemorrhage, Traumatic	3%
486	Carotid Artery, Internal, Dissection	3%
487	Obesity	2.9%
488	Autonomic Dysreflexia	2.9%
489	Complex Regional Pain Syndromes	2.9%
490	Diffuse Axonal Injury	2.8%
491	Empty Sella Syndrome	2.8%
492	Hyperpituitarism	2.8%
493	Hypopituitarism	2.8%
494	Hypophysitis	2.8%
495	Brain Stem Neoplasms	2.8%
496	Subacute Sclerosing Panencephalitis	2.8%
497	Cerebral Arterial Diseases	2.8%
498	Vertebrobasilar Insufficiency	2.8%
499	Basilar Artery Stenosis	2.8%
500	Vertebral Artery Stenosis	2.8%
501	Intracranial Hemorrhage, Hypertensive	2.8%
502	Transient Cerebral Ischemia	2.8%
503	Vertebral Artery Dissection	2.8%
504	Lateral Medullary Syndrome	2.8%
505	Prune Belly Syndrome	2.8%
506	Twins, Conjoined	2.8%
507	Waardenburg Syndrome	2.8%
508	Scimitar Syndrome	2.8%
509	Kwashiorkor	2.8%
510	Magnesium Deficiency	2.8%
511	Potassium Deficiency	2.8%
512	Protein Deficiency	2.8%
513	Avitaminosis	2.8%
514	Central Nervous System Bacterial Infections	2.8%
515	Microcephaly	2.7%
516	Macrocephaly	2.7%
517	Ophthalmia Neonatorum	2.7%
518	Denys-Drash Syndrome	2.7%
519	Meningomyelocele	2.6%
520	Spina Bifida	2.6%
521	Lambert-Eaton Myasthenic Syndrome	2.6%
522	Brain Contusion	2.6%
523	Peripheral Nerve Injuries	2.6%
524	Myasthenia Gravis	2.6%
525	Brain Concussion	2.5%
526	Scrapie	2.5%
527	Central Cord Syndrome	2.5%
528	Chorea	2.5%
529	Carotid Stenosis	2.5%
530	Intracranial Aneurysm	2.5%
531	Guillain-Barre Syndrome	2.5%
532	Intracranial Arteriosclerosis	2.5%
533	Cerebral Atherosclerosis	2.5%
534	Subarachnoid Hemorrhage	2.5%
535	Cerebral Arteriosclerosis	2.5%
536	Cerebral Hemorrhage	2.5%
537	Cerebral Thrombosis	2.5%
538	Intracranial Embolism	2.5%
539	Intracranial Thrombosis	2.5%
540	Anophthalmos	2.5%
541	Anus, Imperforate	2.5%
542	Microphthalmos	2.5%
543	Paralysis, Obstetric	2.5%
544	Retinopathy of Prematurity	2.5%
545	Limb Deformities, Congenital	2.5%
546	Craniofacial Abnormalities	2.5%
547	Anorectal Malformations	2.5%
548	POEMS Syndrome	2.4%
549	Bronchopulmonary Dysplasia	2.4%
550	Meningitis, Cryptococcal	2.4%
551	Meningitis, Listeria	2.4%
552	Meningitis, Haemophilus	2.4%
553	Meningitis, Pneumococcal	2.4%
554	Porencephaly	2.4%
555	Cluster Headache	2.4%
556	Migraine with Aura	2.4%
557	Familial Hemiplegic Migraine	2.4%
558	Chronic Paroxysmal Hemicrania	2.4%
559	SUNCT Syndrome	2.4%
560	Paroxysmal Hemicrania	2.4%
561	Acrocephalosyndactylia	2.4%
562	Giant Cell Arteritis	2.4%
563	Temporal Arteritis	2.4%
564	Craniosynostosis	2.4%
565	Syndactyly	2.4%
566	Brachycephaly	2.4%
567	Sleep Disorders, Circadian Rhythm	2.3%
568	Meningocele	2.3%
569	Encephalocele	2.3%
570	Botulism	2.3%
571	Carotid Artery Thrombosis	2.2%
572	Alice in Wonderland Syndrome	2.2%
573	Blepharophimosis	2.2%
574	Laryngostenosis	2.2%
575	Mouth Abnormalities	2.2%
576	Respiratory Distress Syndrome, Newborn	2.2%
577	Neuromyelitis Optica	2.2%
578	Esophageal Atresia	2.2%
579	Intestinal Atresia	2.2%
580	Horseshoe Kidney	2.2%
581	Pectus excavatum	2.2%
582	Noonan Syndrome	2.2%
583	Klippel-Feil Syndrome	2.2%
584	Gastroschisis	2.2%
585	Synostosis	2.2%
586	Acrodermatitis	2.2%
587	Lymphangiectasis, Intestinal	2.2%
588	Gianotti-Crosti Syndrome	2.2%
589	Torticollis	2.1%
590	Obesity, Abdominal	2.1%
591	Choroid Plexus Papilloma	2.1%
592	Hyperprolactinemia	2.1%
593	Olfactory Nerve Injuries	2.1%
594	Subclavian Steal Syndrome	2.1%
595	Pick Disease of the Brain	2.1%
596	Dysautonomia	2.1%
597	Vagus Nerve Disorder	2.1%
598	Glossopharyngeal Neuralgia	2.1%
599	Abducens Nerve Diseases	2.1%
600	Heavy Metal Poisoning, Nervous System	2.1%
601	Neuromuscular Junction Diseases	2.1%
602	Tauopathies	2.1%
603	Trochlear Nerve Diseases	2.1%
604	Peripheral Nervous System Diseases	2.1%
605	Ascorbic Acid Deficiency	2.1%
606	Vitamin A Deficiency	2.1%
607	Vitamin D Deficiency	2.1%
608	Vitamin E Deficiency	2.1%
609	Marasmus	2.1%
610	Cleft Palate	2.1%
611	West Nile Fever	2%
612	Progressive bulbar palsy	2%
613	Bulbar palsy	2%
614	Arthrogryposis	2%
615	Choanal Atresia	2%
616	Tracheobronchomegaly	2%
617	Laryngocele	2%
618	Choledochal Cyst	2%
619	Hermaphroditism	2%
620	Disorders of Sex Development	2%
621	Causalgia	2%
622	Cryptorchidism	2%
623	Hypospadias	2%
624	Horner Syndrome	2%
625	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.9%
626	Facial Nerve Injuries	1.9%
627	Pediatric Obesity	1.9%
628	Jaw Abnormalities	1.9%
629	Acromegaly	1.9%
630	Myopathy	1.9%
631	Optic Neuropathy	1.9%
632	Sinus Thrombosis, Intracranial	1.9%
633	Facial Nerve Diseases	1.9%
634	Craniocerebral Trauma	1.9%
635	Parasomnia	1.9%
636	Dyssomnias	1.9%
637	Vestibulocochlear Nerve Diseases	1.8%
638	Decerebrate State	1.8%
639	Hemiparesis	1.8%
640	Meningism	1.8%
641	Paresis	1.8%
642	Seizures	1.8%
643	Sensation Disorders	1.8%
644	Central Nervous System Neoplasms	1.8%
645	Complex partial seizures	1.8%
646	Monoparesis	1.8%
647	Neurogenic Inflammation	1.8%
648	Gait Disorders, Neurologic	1.8%
649	Neuromuscular Manifestations	1.8%
650	Sweating, Gustatory	1.8%
651	Auriculotemporal Syndrome	1.8%
652	Spinal Cord Ischemia	1.8%
653	Laryngomalacia	1.8%
654	Dermal Sinus	1.8%
655	Spina Bifida Cystica	1.8%
656	Spina Bifida Occulta	1.8%
657	Lissencephaly	1.8%
658	Polymicrogyria	1.8%
659	Pachygyria	1.8%
660	Schizencephaly	1.8%
661	Periventricular Nodular Heterotopia	1.8%
662	Hematoma, Subdural	1.8%
663	Hematoma, Epidural, Cranial	1.8%
664	Tuberculosis, Central Nervous System	1.8%
665	Pectus carinatum	1.8%
666	Multiple Sclerosis	1.8%
667	Bladder Exstrophy	1.8%
668	Epispadias	1.8%
669	Jet Lag Syndrome	1.8%
670	Multicystic Dysplastic Kidney	1.8%
671	Myasthenia Gravis, Autoimmune, Experimental	1.8%
672	Poland Syndrome	1.7%
673	Folic Acid Deficiency	1.7%
674	Pellagra	1.7%
675	Thiamine Deficiency	1.7%
676	Vitamin B 12 Deficiency	1.7%
677	Vitamin B 6 Deficiency	1.7%
678	Pyridoxine Deficiency	1.7%
679	Pupil Disorders	1.7%
680	Neurobehavioral Manifestations	1.7%
681	Paraneoplastic Encephalomyelitis	1.7%
682	Uveomeningoencephalitic Syndrome	1.6%
683	Ophthalmoplegia	1.6%
684	External Ophthalmoplegia	1.6%
685	Sturge-Weber Syndrome	1.6%
686	Vertigo	1.6%
687	Alcohol-Induced Disorders, Nervous System	1.6%
688	Neuroaspergillosis	1.6%
689	Vitamin K Deficiency	1.6%
690	Amelia	1.6%
691	Arachnodactyly	1.6%
692	Ectopia Cordis	1.6%
693	Ectromelia	1.6%
694	Hemimelia	1.6%
695	Phocomelia	1.6%
696	Reflex Sympathetic Dystrophy	1.6%
697	Sirenomelia	1.6%
698	Polydactyly	1.6%
699	Brachydactyly	1.6%
700	Plagiocephaly	1.6%
701	Lower Extremity Deformities, Congenital	1.6%
702	Upper Extremity Deformities, Congenital	1.6%
703	Nocturnal Myoclonus Syndrome	1.6%
704	Single umbilical artery	1.6%
705	Tardive Dyskinesia	1.6%
706	Cavernous Sinus Thrombosis	1.6%
707	Sagittal Sinus Thrombosis	1.6%
708	Beriberi	1.5%
709	Prolactinoma	1.5%
710	Growth Hormone-Secreting Pituitary Adenoma	1.5%
711	Pseudorabies	1.5%
712	Vocal Cord Paralysis	1.5%
713	Voice Disorders	1.5%
714	Voice Disturbance	1.5%
715	Micrognathism	1.5%
716	Pierre Robin Syndrome	1.5%
717	Neurosyphilis	1.4%
718	Aortic coarctation	1.4%
719	Cor Triatriatum	1.4%
720	Coronary Vessel Anomalies	1.4%
721	Dental Enamel Hypoplasia	1.4%
722	Patent ductus arteriosus	1.4%
723	Ebstein Anomaly	1.4%
724	Heart Septal Defects	1.4%
725	Hyaline Membrane Disease	1.4%
726	Hypodontia	1.4%
727	Macrostomia	1.4%
728	Microstomia	1.4%
729	Tetralogy of Fallot	1.4%
730	Transposition of Great Vessels	1.4%
731	Hypoplastic Left Heart Syndrome	1.4%
732	May-Thurner Syndrome	1.4%
733	Craniofacial Dysostosis	1.4%
734	Acrodynia	1.4%
735	Wolff-Parkinson-White Syndrome	1.4%
736	Hematoma, Subdural, Intracranial	1.4%
737	Hematoma, Subdural, Chronic	1.4%
738	Hematoma, Subdural, Acute	1.4%
739	Nelson Syndrome	1.4%
740	Hyperandrogenism	1.4%
741	Retrognathia	1.4%
742	Alcohol Withdrawal Seizures	1.4%
743	Anemia, Pernicious	1.4%
744	Scurvy	1.3%
745	Reflex, Abnormal	1.3%
746	Hyporeflexia	1.3%
747	Hyperreflexia	1.3%
748	Lyme Neuroborreliosis	1.3%
749	Long QT Syndrome	1.3%
750	Platybasia	1.3%
751	Tricuspid Atresia	1.3%
752	Arrhythmogenic Right Ventricular Dysplasia	1.3%
753	Gonadal Dysgenesis	1.3%
754	Bronchomalacia	1.3%
755	Adrenogenital Syndrome	1.3%
756	Tracheomalacia	1.3%
757	Ovotesticular Disorders of Sex Development	1.3%
758	Cerebrospinal Fluid Otorrhea	1.3%
759	Cerebrospinal Fluid Rhinorrhea	1.3%
760	Neuritis, Autoimmune, Experimental	1.3%
761	Gait Ataxia	1.3%
762	Prognathism	1.3%
763	Brachial Plexus Neuritis	1.2%
764	Neuralgic Amyotrophy	1.2%
765	Anterior Spinal Artery Syndrome	1.2%
766	Akathisia	1.2%
767	Restlessness	1.2%
768	Psychomotor Agitation	1.2%
769	Coma, Post-Head Injury	1.2%
770	Neuritis	1.2%
771	Polyneuritis	1.2%
772	Radiculitis	1.2%
773	Polyneuropathy	1.2%
774	Mononeuritis	1.2%
775	Mononeuropathies	1.2%
776	Brachial Plexus Neuropathies	1.2%
777	Radiculopathy	1.2%
778	Mononeuropathy Multiplex	1.2%
779	Nerve Root Compression	1.2%
780	Waterhouse-Friderichsen Syndrome	1.1%
781	Optic Nerve Glioma	1.1%
782	Acoustic Neuroma	1.1%
783	Malaria, Cerebral	1.1%
784	Neurocysticercosis	1.1%
785	Aortopulmonary Septal Defect	1.1%
786	Double Outlet Right Ventricle	1.1%
787	Endocardial Cushion Defects	1.1%
788	Multiple Sclerosis, Chronic Progressive	1.1%
789	Multiple Sclerosis, Relapsing-Remitting	1.1%
790	Myocardial bridging	1.1%
791	Aorticopulmonary Septal Defect	1.1%
792	Gait Apraxia	1%
793	Myositis	1%
794	Optic Atrophy	1%
795	Optic Neuritis	1%
796	Papilledema	1%
797	Strabismus	1%
798	Tolosa-Hunt Syndrome	1%
799	Isaacs syndrome	1%
800	Arsenic Poisoning	1%
801	Myotonic Disorders	1%
802	Diabetic Neuropathies	1%
803	Facial Injuries	1%
804	Facial Neuralgia	1%
805	Diabetic Amyotrophy	1%
806	Diabetic Autonomic Neuropathy	1%
807	Sleep Talking	1%
808	Manganese Poisoning	1%
809	Sleep Disorders, Intrinsic	1%
810	Orthostatic intolerance	1%
811	Anosmia	1%
812	Ataxia	1%
813	Athetosis	1%
814	Catalepsy	1%
815	Dystonia	1%
816	Hemiplegia	1%
817	Locked-In Syndrome	1%
818	Meningeal Neoplasms	1%
819	Muscle Hypertonia	1%
820	Muscle hypotonia	1%
821	Myoclonus	1%
822	Myotonia	1%
823	Neuralgia	1%
824	Paraplegia	1%
825	Pseudobulbar Palsy	1%
826	Quadriplegia	1%
827	Spasm	1%
828	Spastic Paraplegia	1%
829	Status Epilepticus	1%
830	Taste Disorders	1%
831	Tremor	1%
832	Monoplegia	1%
833	Hypokinesia	1%
834	Paraparesis	1%
835	Bradykinesia	1%
836	Waxy flexibility	1%
837	Action Tremor	1%
838	Resting Tremor	1%
839	Dysosmia	1%
840	Quadriparesis	1%
841	Mercury Poisoning, Nervous System	1%
842	Olfaction Disorders	1%
843	Myokymia	1%
844	Lead Poisoning, Nervous System	1%
845	Vestibular Neuronitis	1%
846	Somatosensory Disorders	1%
847	Neuropathic pain	1%
848	Hyperkinesia	1%
849	Intention tremor	1%
850	Tarsal Tunnel Syndrome	1%
851	Cauda Equina Syndrome	1%
852	Mandibulofacial Dysostosis	1%
853	Romano-Ward Syndrome	1%
854	Hand-Arm Vibration Syndrome	0.9%
855	Vision Disorders	0.9%
856	Metamorphopsia	0.9%
857	Visual Impairment	0.9%
858	Fibromyalgia	0.9%
859	Optic Neuropathy, Ischemic	0.9%
860	Anterior Ischemic Optic Neuropathy	0.9%
861	Medial Tibial Stress Syndrome	0.9%
862	Facial Hemiatrophy	0.9%
863	Melkersson-Rosenthal Syndrome	0.9%
864	Anisocoria	0.9%
865	Confusion	0.9%
866	Facial paralysis	0.9%
867	Lethargy	0.9%
868	Memory Disorders	0.9%
869	Muscle Cramp	0.9%
870	Perceptual Disorders	0.9%
871	Psychomotor Disorders	0.9%
872	Tonic Pupil	0.9%
873	Eosinophilia-Myalgia Syndrome	0.9%
874	Anhedonia	0.9%
875	Disorientation	0.9%
876	Facial Paresis	0.9%
877	Memory Loss	0.9%
878	Hemisensory Neglect	0.9%
879	Dysacusis	0.9%
880	Sleep Bruxism	0.9%
881	Muscular Atrophy	0.9%
882	Respiratory Paralysis	0.9%
883	Carpal Tunnel Syndrome	0.9%
884	neurofibroma	0.9%
885	Sciatica	0.9%
886	Truncus Arteriosus, Persistent	0.9%
887	Goldenhar Syndrome	0.9%
888	Consciousness Disorders	0.8%
889	Mental Retardation	0.8%
890	Muscle Weakness	0.8%
891	Depressed Level of Consciousness	0.8%
892	Mental deficiency	0.8%
893	Intellectual Disability	0.8%
894	Bell Palsy	0.8%
895	Catatonia	0.8%
896	Herpes Zoster Oticus	0.8%
897	Aphonia	0.8%
898	Sleep Deprivation	0.8%
899	Dysphonia	0.8%
900	Arteriovenous fistula	0.8%
901	Talipes	0.8%
902	Myalgia	0.7%
903	Congenital clubfoot	0.7%
904	Vertical Talus	0.7%
905	Cubital Tunnel Syndrome	0.7%
906	Sciatic Neuropathy	0.7%
907	Ulnar Neuropathies	0.7%
908	Lesion of Sciatic Nerve	0.7%
909	Ulnar Neuritis	0.7%
910	Radial nerve compression	0.7%
911	Radial Tunnel Syndrome	0.7%
912	Peroneal Neuropathies	0.7%
913	Radial Neuropathy	0.7%
914	Median Neuropathy	0.7%
915	Sciatic Nerve Palsy	0.7%
916	Femoral Neuropathy	0.7%
917	Tibial Neuropathy	0.7%
918	Ulnar Nerve Palsy	0.7%
919	Postural Orthostatic Tachycardia Syndrome	0.7%
920	Radial nerve palsy	0.7%
921	Hoarseness	0.7%
922	Alcohol Withdrawal Delirium	0.7%
923	Thoracic Outlet Syndrome	0.6%
924	Esotropia	0.6%
925	Exotropia	0.6%
926	Hypotension, Orthostatic	0.6%
927	Sleep Apnea Syndromes	0.6%
928	Polymyositis	0.6%
929	Post-Exercise Hypotension	0.6%
930	Disorders of Excessive Somnolence	0.6%
931	Sleep Initiation and Maintenance Disorders	0.6%
932	Night Terrors	0.6%
933	Somnambulism	0.6%
934	Trigeminal Nerve Disorder	0.6%
935	Transient Insomnia	0.6%
936	Sleep Paralysis	0.6%
937	Chronic Insomnia	0.6%
938	REM Sleep Behavior Disorder	0.6%
939	Hypersomnia	0.6%
940	Dysgeusia	0.6%
941	Formication	0.6%
942	Hyperalgesia	0.6%
943	Hyperesthesia	0.6%
944	Hypesthesia	0.6%
945	Language Disorders	0.6%
946	Numbness	0.6%
947	Paresthesia	0.6%
948	Paraparesis, Spastic	0.6%
949	Trismus	0.6%
950	Epilepsia Partialis Continua	0.6%
951	Hypogeusia	0.6%
952	Meningeal Carcinomatosis	0.6%
953	Brown-Sequard Syndrome	0.6%
954	Lockjaw	0.6%
955	Allodynia	0.6%
956	Lead Poisoning, Nervous System, Childhood	0.6%
957	Lead Poisoning, Nervous System, Adult	0.6%
958	Ageusia	0.6%
959	Alexia	0.6%
960	Dyslexia	0.6%
961	Eye Injuries	0.6%
962	Orbital Myositis	0.5%
963	Diplopia	0.5%
964	Muscle Rigidity	0.5%
965	Muscle Spasticity	0.5%
966	Scotoma	0.5%
967	Photophobia	0.5%
968	Cogwheel Rigidity	0.5%
969	Hemifacial Spasm	0.5%
970	Amaurosis	0.5%
971	Blindness	0.5%
972	Nuchal Rigidity	0.5%
973	Pyomyositis	0.5%
974	Agnosia	0.5%
975	Apraxias	0.5%
976	Hallucinations	0.5%
977	Hemianopsia	0.5%
978	Hyperacusis	0.5%
979	Tinnitus	0.5%
980	Visual Agnosia	0.5%
981	Anosognosia	0.5%
982	Wernicke-Korsakoff Syndrome	0.5%
983	Phonophobia	0.5%
984	Hearing Loss	0.5%
985	Sarcopenia	0.5%
986	Neurofibrosarcoma	0.5%
987	Amnesia	0.5%
988	Delirium	0.5%
989	Dissociative Amnesia	0.5%
990	Color blindness	0.5%
991	Global Amnesia	0.5%
992	Meningioma	0.5%
993	Polyradiculopathy	0.5%
994	Phantom pain	0.4%
995	Phantom Limb Pain	0.4%
996	Sleep Apnea, Obstructive	0.4%
997	Sleep Apnea, Central	0.4%
998	Narcolepsy	0.4%
999	Trigeminal Neuralgia	0.4%
1000	Kleine-Levin Syndrome	0.4%
1001	Agraphia	0.4%
1002	Anomia	0.4%
1003	Cluttering	0.4%
1004	Language Development Disorders	0.4%
1005	Speech Disorders	0.4%
1006	Syncope	0.4%
1007	Stupor	0.4%
1008	Dysgraphia	0.4%
1009	Presyncope	0.4%
1010	Dyslalia	0.4%
1011	Eye Burns	0.4%
1012	Amaurosis Fugax	0.4%
1013	Blindness, Cortical	0.4%
1014	Dyscalculia	0.4%
1015	Deafness	0.4%
1016	Hearing Loss, Sudden	0.4%
1017	Gerstmann Syndrome	0.4%
1018	Hearing Loss, Bilateral	0.4%
1019	Hearing Loss, High-Frequency	0.4%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.4%
1021	Prosopagnosia	0.4%
1022	Apraxia, Ideomotor	0.4%
1023	Charles Bonnet Syndrome	0.4%
1024	Hearing Loss, Unilateral	0.4%
1025	Complete Hearing Loss	0.4%
1026	Alien Hand Syndrome	0.4%
1027	Deaf Mutism	0.4%
1028	Dermatomyositis	0.3%
1029	Corneal Scar	0.3%
1030	Retrograde amnesia	0.3%
1031	Amnesia, Anterograde	0.3%
1032	Cataplexy	0.3%
1033	Aphasia	0.3%
1034	Articulation Disorders	0.3%
1035	Echolalia	0.3%
1036	Stuttering	0.3%
1037	Dysphasia	0.3%
1038	Mutism	0.3%
1039	Selective Mutism	0.3%
1040	Dysarthria	0.2%
1041	Corneal Perforation	0.2%
1042	Alexia, Pure	0.2%

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