MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Calciphylaxis

(UMLS:C0006666)

Definition:: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.
UMLS ID:: C0006666
MeSH ID:: D002115

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.174.130.186

Synonym(s)

Calciphylaxis

calciphylaxes

calciphylaxis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Warfarin	FAERS: 127 Canada Vigilance: 6	Canada Vigilance OFFSIDES US FAERS
2	Warfarin	FAERS: 94 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Cinacalcet	FAERS: 35 Canada Vigilance: 1	Canada Vigilance US FAERS
4	reviparin	FAERS: 6	US FAERS
5	Iron citrate	FAERS: 4	US FAERS
6	paricalcitol	FAERS: 4	OFFSIDES US FAERS
7	AMG-416	FAERS: 3	US FAERS
8	Prednisolone	FAERS: 3	US FAERS
9	Teriparatide	FAERS: 3	US FAERS
10	Thalidomide	FAERS: 3	US FAERS
11	Exenatide	FAERS: 2	US FAERS
12	apixaban	FAERS: 2	US FAERS
13	1 alpha-hydroxyergocalciferol	FAERS: 1	OFFSIDES US FAERS
14	Bortezomib	FAERS: 1	US FAERS
15	Canagliflozin	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
16	Dabigatran	FAERS: 1	US FAERS
17	Ergocalciferols	FAERS: 1	US FAERS
18	Pamidronate	FAERS: 1	US FAERS
19	Sevelamer	FAERS: 1	OFFSIDES US FAERS
20	Tacrolimus	FAERS: 1	US FAERS
21	Temazepam	FAERS: 1	US FAERS
22	Valganciclovir	FAERS: 1	US FAERS
23	Zoledronic Acid	FAERS: 1	US FAERS
24	ambrisentan	FAERS: 1	US FAERS
25	gadodiamide	FAERS: 1	US FAERS
26	montelukast	FAERS: 1	US FAERS
27	teduglutide	FAERS: 1	US FAERS
28	Acyclovir		OFFSIDES
29	Amikacin		OFFSIDES
30	Anastrozole		OFFSIDES
31	Azathioprine		OFFSIDES
32	Calcitriol		OFFSIDES
33	Calcium Carbonate	Canada Vigilance: 12	Canada Vigilance
34	Celiprolol		OFFSIDES
35	Cinacalcet		OFFSIDES
36	Colchicine		OFFSIDES
37	Daunorubicin		OFFSIDES
38	Digitoxin		OFFSIDES
39	Fludrocortisone		OFFSIDES
40	Fondaparinux		OFFSIDES
41	Gadolinium		OFFSIDES
42	Gatifloxacin		OFFSIDES
43	Hydroxyzine		OFFSIDES
44	Methocarbamol		OFFSIDES
45	Midodrine		OFFSIDES
46	Mupirocin		OFFSIDES
47	Nefopam		OFFSIDES
48	Nitrendipine		OFFSIDES
49	Norethindrone Acetate		OFFSIDES
50	Pantoprazole		OFFSIDES
51	Phenprocoumon		OFFSIDES
52	Phosphates		OFFSIDES
53	Potassium Acetate		OFFSIDES
54	Pyridostigmine Bromide		OFFSIDES
55	Sevelamer		OFFSIDES
56	Sirolimus		OFFSIDES
57	Sodium Bicarbonate		OFFSIDES
58	Spironolactone		OFFSIDES
59	Sulfate		OFFSIDES
60	Tamoxifen		OFFSIDES
61	Tobramycin		OFFSIDES
62	Vincristine		OFFSIDES
63	Vitamin B 12		OFFSIDES
64	alfacalcidol		OFFSIDES
65	calcium acetate		OFFSIDES
66	colestimide		SIDER
67	deflazacort		OFFSIDES
68	desloratadine		OFFSIDES
69	dihydrocodeine		OFFSIDES
70	gadodiamide		OFFSIDES
71	gadoversetamide		OFFSIDES
72	polystyrene sulfonic acid		OFFSIDES
73	valdecoxib		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Vascular calcification	48.4%
2	Hypercalcemia	33%
3	Hypocalcemia	33%
4	Milk-Alkali Syndrome	33%
5	Acid-Base Imbalance	25.4%
6	Iron Metabolism Disorders	25.4%
7	Phosphorus Metabolism Disorders	25.4%
8	Water-Electrolyte Imbalance	25.4%
9	Lipid Metabolism Disorders	25.4%
10	Mitochondrial Diseases	25.4%
11	Glucose Metabolism Disorders	25.4%
12	Nephrocalcinosis	24.4%
13	Wasting Syndrome	23%
14	Rickets	20.5%
15	Pseudohypoparathyroidism	19.7%
16	Osteopenia	17.2%
17	Brain Diseases, Metabolic	16.9%
18	Nutrition Disorders	16.4%
19	Lipodystrophy	14.9%
20	Acidosis	14.8%
21	Alkalosis	14.8%
22	Amyloidosis	14.8%
23	Hyperglycemia	14.8%
24	Hyperinsulinism	14.8%
25	Hyperkalemia	14.8%
26	Hypernatremia	14.8%
27	Hypoglycemia	14.8%
28	Hypokalemia	14.8%
29	Hyponatremia	14.8%
30	Xanthomatosis	14.8%
31	Hypophosphatemia	14.8%
32	Metabolic acidosis	14.8%
33	Dyslipidemias	14.8%
34	Iron Overload	14.8%
35	Xanthoma	14.8%
36	CREST Syndrome	13.9%
37	Osteomalacia	13.6%
38	Brain Diseases, Metabolic, Inborn	11.8%
39	Tetany	11.4%
40	Diabetes Mellitus	10.6%
41	Hyperhomocysteinemia	10.5%
42	Leigh Disease	10.3%
43	Dehydration	10.1%
44	Lipomatosis	10.1%
45	Water Intoxication	10.1%
46	Werner Syndrome	10.1%
47	Achlorhydria	9.9%
48	Amino Acid Metabolism, Inborn Errors	9.9%
49	Bloom Syndrome	9.9%
50	Carbohydrate Metabolism, Inborn Errors	9.9%
51	Metal Metabolism, Inborn Errors	9.9%
52	Osteoporosis	9.9%
53	Progeria	9.9%
54	Lysosomal Storage Diseases	9.9%
55	Bone Demineralization, Pathologic	9.9%
56	Cytochrome-c Oxidase Deficiency	9.9%
57	Peroxisomal Disorders	9.9%
58	Post-Traumatic Osteoporosis	9.9%
59	Celiac Disease	9.8%
60	Sprue, Tropical	9.8%
61	Steatorrhea	9.8%
62	Sprue	9.8%
63	Lactose Intolerance	9.7%
64	Acidosis, Lactic	9.7%
65	Hemosiderosis	9.7%
66	Hypolipoproteinemias	9.7%
67	Ketosis	9.7%
68	Ketonuria	9.7%
69	Ketoacidosis	9.7%
70	Ketonemia	9.7%
71	Carbamoyl-Phosphate Synthase I Deficiency Disease	9%
72	Hyperlipoproteinemia Type IV	8.6%
73	Hyperlipoproteinemia Type V	8.6%
74	Renal Osteodystrophy	8.5%
75	Renal rickets	8.5%
76	Diabetic Ketoacidosis	8.5%
77	Child Nutrition Disorders	8.5%
78	Hypervitaminosis A	8.5%
79	Infant Nutrition Disorders	8.5%
80	Malnutrition	8.5%
81	Hyperlipidemia, Familial Combined	8.4%
82	Smith-Lemli-Opitz Syndrome	8.3%
83	Familial Hypophosphatemic Rickets	8.3%
84	Galactosemias	8.3%
85	Urea Cycle Disorders, Inborn	8.3%
86	Tyrosinemias	8.3%
87	Mitochondrial Encephalomyopathies	8.2%
88	Congenital Hyperinsulinism	8.1%
89	Hyperlipoproteinemia Type III	7.8%
90	Mitochondrial Myopathies	7.6%
91	Myelinolysis, Central Pontine	7.5%
92	Glycosuria	7.4%
93	Reye Syndrome	7.4%
94	Hepatic Encephalopathy	7.3%
95	Hyperphosphaturia	7.2%
96	Hypercholesterolemia	7.2%
97	Hyperlipoproteinemias	7.2%
98	Hypertriglyceridemia	7.2%
99	Hypoalphalipoproteinemias	7.2%
100	Homocystinuria	6.7%
101	HIV Wasting Syndrome	6.5%
102	Acidosis, Respiratory	6.5%
103	Adiposis Dolorosa	6.5%
104	Alkalosis, Respiratory	6.5%
105	Alkaptonuria	6.5%
106	Glycogen Storage Disease	6.5%
107	Hypophosphatasia	6.5%
108	Insulin Resistance	6.5%
109	Osteoporosis, Postmenopausal	6.5%
110	Propionic acidemia	6.5%
111	Dihydropyrimidine Dehydrogenase Deficiency	6.5%
112	Cystinosis	6.5%
113	Renal tubular acidosis	6.4%
114	Glycogen storage disease type II	6.4%
115	Gaucher Disease	6.2%
116	Amyloid Neuropathies, Familial	6.1%
117	Porphyrias, Hepatic	6%
118	Necrobiosis Lipoidica Diabeticorum	5.9%
119	Fanconi Anemia	5.8%
120	Nesidioblastosis	5.8%
121	Neuronal Ceroid-Lipofuscinoses	5.7%
122	HIV-Associated Lipodystrophy Syndrome	5.5%
123	Wernicke Encephalopathy	5.5%
124	Zellweger Syndrome	5.3%
125	MELAS Syndrome	5.3%
126	Menkes Kinky Hair Syndrome	5.3%
127	Adrenoleukodystrophy	5.1%
128	Gestational Diabetes	5.1%
129	Latent Autoimmune Diabetes in Adults	5.1%
130	Tay-Sachs Disease	5.1%
131	Diabetes Mellitus, Experimental	5%
132	Niemann-Pick Disease, Type C	4.9%
133	Deficiency Diseases	4.9%
134	Starvation	4.9%
135	Refeeding Syndrome	4.9%
136	Hepatolenticular Degeneration	4.9%
137	Friedreich Ataxia	4.9%
138	Refsum Disease	4.8%
139	Glycosuria, Renal	4.8%
140	Cerebral Amyloid Angiopathy	4.8%
141	Glycogen Storage Disease Type I	4.8%
142	Glycogen Storage Disease Type V	4.8%
143	Mucopolysaccharidosis III	4.8%
144	Fabry Disease	4.8%
145	Kernicterus	4.3%
146	Cockayne Syndrome	4.2%
147	Familial Periodic Paralysis	4%
148	Primary amyloidosis	3.9%
149	Kearns-Sayre syndrome	3.9%
150	Variegate Porphyria	3.9%
151	Acute intermittent porphyria	3.9%
152	Porphyria Cutanea Tarda	3.9%
153	Renal Aminoacidurias	3.9%
154	Fanconi Syndrome	3.9%
155	Pseudohypoaldosteronism	3.9%
156	Liddle Syndrome	3.9%
157	Ataxia Telangiectasia	3.8%
158	Optic Atrophy, Hereditary, Leber	3.7%
159	Sjogren-Larsson Syndrome	3.4%
160	Xeroderma Pigmentosum	3.3%
161	Gout	3.3%
162	Amyotrophic Lateral Sclerosis	3.3%
163	Antley-Bixler Syndrome Phenotype	3.2%
164	Canavan Disease	3.2%
165	Alexander Disease	3.2%
166	Kwashiorkor	3.2%
167	Magnesium Deficiency	3.2%
168	Potassium Deficiency	3.2%
169	Protein Deficiency	3.2%
170	Avitaminosis	3.2%
171	Mucopolysaccharidosis II	3.2%
172	Hypokalemic periodic paralysis	2.9%
173	Frontotemporal dementia	2.9%
174	Cystinuria	2.9%
175	Albinism	2.5%
176	Arthritis, Gouty	2.4%
177	Ascorbic Acid Deficiency	2.4%
178	Vitamin A Deficiency	2.4%
179	Vitamin D Deficiency	2.4%
180	Vitamin E Deficiency	2.4%
181	Marasmus	2.4%
182	Folic Acid Deficiency	2%
183	Pellagra	2%
184	Thiamine Deficiency	2%
185	Vitamin B 12 Deficiency	2%
186	Vitamin B 6 Deficiency	2%
187	Pyridoxine Deficiency	2%
188	Ichthyosis, X-Linked	2%
189	Obesity	1.9%
190	Beriberi	1.8%
191	Obesity, Abdominal	1.6%
192	Pediatric Obesity	1.3%
193	Vitamin K Deficiency	1.2%
194	Anemia, Pernicious	1.2%
195	Prader-Willi Syndrome	1.1%
196	Scurvy	1%
197	Subacute Combined Degeneration	0.6%

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