MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Parkinsonian Disorders

(UMLS:C0242422)

Definition:: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
UMLS ID:: C0242422
MeSH ID:: D020734

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.079.862|C10.228.662.600

Synonym(s)

Parkinsonian Disorders

PARKINSONISM

Parkinsonian Symptoms

Parkinsonism

Parkinsonism, NOS

parkinsonian disease

parkinsonian disorders

parkinsonian syndrome

parkinsonian syndromes

10.

parkinsonism

11.

parkinsonisms

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	View details 1591961 1642462 1681090 1780015 2057003 2296255 2296259 2320253 2576311 2611764 3495642 6608979 7616686 7663983 7688878 7953674 8098931 8106150 8617407 8619541 8749992 8915594 9103530 9266731 9270571 9864283 9930741 10495035 10762135 10762498 11020123 11168568 11222455 11520128 11869030 12123699 12349958 12373562 12465055 12465074 12504871 12740572 14534244 14568327 14573388 14673879 14743355 14757136 15004218 15006686 15207281 15226382 15514976 15621629 15802193 15837582 15894565 15954116 16026462 16029219 16127720 16437566 16739115 16950226 16960862 17335811 17350277 17486685 17588764 17630359 17640816 17960553 17992687 18093171 18160641 18175345 18534670 18650331 18702732 18704766 18952677 19118628 19196540 19476553 19501164 19694610 19852073 20014115 20118623 20132464 20143419 20169779 20303391 20452426 20456008 20808799 20882603 20966038 21591752 21605582 21714510 22746536 22842585 22891246 23754278 23911879 23933227 24607817 24768735 24991814 24995576 25053526 25064079 27277809 30195017 30529163	CTD
2	1-Methyl-4-phenylpyridinium	View details 18069091 23298529 24875324 25868679 27432061 29631008	CTD
3	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	11222455	CTD
4	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	23911879	CTD
5	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	20206263	CTD
6	3-iodotyrosine	29885340	CTD
7	3-n-butylphthalide	21524431	CTD
8	4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline	2576311	CTD
9	4-hydroxy-2-nonenal	16141792	CTD
10	6-methyl-2-(phenylethynyl)pyridine	12097518	CTD
11	Amantadine	View details 4327681 4553409 4838913 20740488 21158687	CTD
12	Amiodarone	7753074 9808703	CTD
13	Amitriptyline	3702925 15613935	CTD
14	Amlodipine	7885347 12210888	CTD
15	Amoxapine	6232518 6711697	CTD
16	Apomorphine	View details 1591961 7616686 8098931 11222455 11481687 11869030 12504871 16960862 18175345	CTD
17	Aprindine	9808703	CTD
18	Arecoline	569589	CTD
19	Aripiprazole	View details 16421466 18480698 19830105 21152153	CTD
20	Baclofen	6321374	CTD
21	Benserazide	15899244 20570206	CTD
22	Benztropine	33969 4405503 9686775	CTD
23	Biperiden	4155670 10389620 12724469	CTD
24	Bromocriptine	View details 572493 666607 1567736 1681090 10683491	CTD
25	Budesonide	16924038	CTD
26	Bupropion	1592841 19910737	CTD
27	Buspirone	17553556	CTD
28	CY 208-243	1681090	CTD
29	Cabergoline	9930741	CTD
30	Cadmium Compounds	19523979 21933187	CTD
31	Carbidopa	2611764 4834974 23206800	CTD
32	Carbon Disulfide	15019297	CTD
33	Cephaloridine	5108409	CTD
34	Chlorpromazine	View details 996201 1631189 4734007 5077102 10389620	CTD
35	Citalopram	21407001	CTD
36	Clonazepam	1362592	CTD
37	Clonidine	10602339	CTD
38	Clozapine	9918355	CTD
39	Creatine	19476553	CTD
40	Dexetimide	4947805	CTD
41	Diazoxide	15795934 15927086	CTD
42	Disulfiram	4321579	CTD
43	Docosahexaenoic Acids	16141792	CTD
44	Donepezil	11180473 14638981	CTD
45	Droperidol	1130732	CTD
46	Enkephalin, Leucine-2-Alanine	11294472	CTD
47	Ethinyl Estradiol-Norgestrel Combination	1567736	CTD
48	Felbamate	7845605	CTD
49	Flunarizine	3351524	CTD
50	GYKI 53405	10762498	CTD
51	Haloperidol	View details 2861619 3946663 3989243 6321374 8098931 9693747 12724469 12974990 16764227 25085534	CTD
52	Homovanillic Acid	8817341	CTD
53	Idazoxan	10495035	CTD
54	Indomethacin	12349958	CTD
55	Ketoconazole	22334051	CTD
56	L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine	2611764	CTD
57	Levodopa	View details 404579 572493 601391 1278088 1654766 1681090 2057003 2296255 3119180 3495642 3504239 4838913 6608979 8619541 8817341 9171869 9261828 9270571 9756148 9918362 10072423 10495035 10654305 10739638 10762135 10762498 11246459 11481687 12465074 12504871 12614340 12740572 14568327 14573388 14673879 15004218 15006686 15782419 15885624 15894565 16026462 16269145 16337943 16639728 17116309 17230470 17241287 17335811 17356338 17499513 17553556 17630359 17992687 17997101 18638717 18722529 19118628 19196540 19908326 20303391 20659451 20736067 21088802 23206800	CTD
58	Linsidomine	16291239	CTD
59	Lopinavir	19908326	CTD
60	M40401	22289031	CTD
61	Malondialdehyde	16141792	CTD
62	Maneb	18386188 22334051 23963992	CTD
63	Manganese Compounds	View details 16140633 16991145 17060373 19607852 20798247 20876035 22975163 23313730 23385959 24060432 24614235 26220508	CTD
64	Melatonin	15574749 23963992	CTD
65	Muscimol	569589	CTD
66	N-(1-methylethyl)-1,1,2-trimethylpropylamine	15795934 15927086	CTD
67	Nicergoline	1567736	CTD
68	Olanzapine	View details 9356581 9810956 18217890 18494081	CTD
69	Oxidopamine	View details 9103530 9171869 10683491 11294472 12127155 12373562 12535962 12585172 14526427 15056471 15342103 15703272 15899244 16095907 16291239 16325337 16365282 16531050 17188499 17192438 17222394 17230470 17588764 17660384 17884291 18160641 18717735 18988638 19159919 19171906 19283364 19399396 19399877 19633584 19686730 20105237 20167206 20504213 20659451 20736067 21085660 21088802 21591752 22016808 22041943 22842585 23357119 23532969 29054324	CTD
70	Paraquat	View details 18386188 22289031 22334051 22721943 23046578 23963992 24887138 26705857 27919828	CTD
71	Paroxetine	15613935	CTD
72	Pergolide	12504871 17356338	CTD
73	Perphenazine	3702925 15613935	CTD
74	Phenol	10465250	CTD
75	Pimozide	235013 4607088 6805002	CTD
76	Piribedil	11222455	CTD
77	Pramipexole	9864283 14534244 17356338	CTD
78	Probenecid	24768735 25064079	CTD
79	Procaine	9808703	CTD
80	Procyclidine	33969	CTD
81	Quetiapine Fumarate	18217890	CTD
82	Quinpirole	View details 1681090 7616686 10739638 15837582	CTD
83	Raclopride	12476322	CTD
84	Reserpine	View details 8527005 9398468 10602339 11358453 11980384 12539206 12774329 15306204	CTD
85	Resveratrol	22334051	CTD
86	Rimonabant	15894565	CTD
87	Risperidone	10389620 18217890 18494081	CTD
88	Ritonavir	19908326	CTD
89	Rivastigmine	17972045	CTD
90	Rotenone	View details 12177198 15574749 15635186 15790535 15795934 15927086 16115015 16490285 18155613 18197244 18308296 18579341 20143419 21383081 21524431 21736921 22041943 23073839 23295396 23357119 23783886 24451142 24755484 25430725 25446015 26075822 26705857 26806867 27016191 27180985 27252111 28238857 28389404 30222980	CTD
91	S 33084	19733554	CTD
92	SCH 23390	7616686	CTD
93	SK&F 82958	View details 7616686 9930741 15306204 15837582	CTD
94	Selegiline	16490285	CTD
95	Sertraline	9660102 15968847	CTD
96	Silymarin	23963992	CTD
97	Tetrabenazine	4607088 9918362	CTD
98	Thiethylperazine	15469457	CTD
99	Thioridazine	7247630	CTD
100	Thiothixene	7247630	CTD
101	Trifluoperazine	1275103 4405372 12724469	CTD
102	Trihexyphenidyl	4838913 15968847	CTD
103	Tropicamide	17594079	CTD
104	Ubiquinone	19476553	CTD
105	Valproic Acid	8797455 11838631	CTD
106	Verapamil	8504444	CTD
107	Zidovudine	9686775	CTD
108	annonacin	18816693	CTD
109	benserazide, levodopa drug combination	View details 1591961 6122974 8106150 11166288 11520128 12373562 12774329 14757136 15056471 15514976 15837582 16029219 16437566 16739115 16950226 17350277 18160641 18175345 18952677 20014115 20456008 20570206 20966038	CTD
110	carbidopa, levodopa drug combination	View details 2320253 2576311 2611764 6122974 9266731 11168568 14743355	CTD
111	carbidopa, levodopa drug combination	1275103 27026137	CTD
112	crocin	26705857	CTD
113	cypermethrin	25370934	CTD
114	dihydrexidine	21714510	CTD
115	dironyl	1681090 8098931	CTD
116	echinacoside	27432061	CTD
117	enadoline	10602339	CTD
118	entacapone	18722529	CTD
119	fluphenazine depot	800383	CTD
120	fluphenazine enanthate	33969	CTD
121	geraniol	27026137	CTD
122	ginsenoside Re	15621629	CTD
123	istradefylline	View details 10739638 12614340 14637099 15899244 27297283	CTD
124	lamivudine, zidovudine drug combination	19908326	CTD
125	lazabemide	22017497	CTD
126	levodopa methyl ester	15703272 15899244 16960862	CTD
127	levosulpiride	9050439	CTD
128	liposomal amphotericin B	6619049 8208424	CTD
129	mancozeb	20960484	CTD
130	monomethylpropion	26220508	CTD
131	naxagolide	1681090	CTD
132	neramexane	10193902	CTD
133	pardoprunox	21591752	CTD
134	preclamol	1681090	CTD
135	profenamine	33969	CTD
136	rasagiline	22017497	CTD
137	ropinirole	10683491 15899244	CTD
138	safinamide	22017497	CTD
139	sesamin	15635186	CTD
140	squamosamide	21295016	CTD
141	thiopropazate	5106314	CTD
142	tofenacin	800383	CTD
143	turmeric extract	25238331	CTD
144	veralipride	7478098 8571284 15936474	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Meige Syndrome	53.7%
2	Multiple System Atrophy	52.2%
3	Encephalomyelitis	45.4%
4	Meningoencephalitis	43.7%
5	Essential Tremor	40.7%
6	Familial Tremor	40.7%
7	Writer's Cramp	40.7%
8	Basal Ganglia Cerebrovascular Disease	40.5%
9	Dystonia Musculorum Deformans	39.9%
10	Subdural Effusion	39.3%
11	Striatonigral Degeneration	37.4%
12	Meningitis	37.1%
13	Pachymeningitis	37.1%
14	Spinal Cord Diseases	37.1%
15	Akinetic Mutism	36.3%
16	Anoxic Encephalopathy	36.3%
17	Brain Damage, Chronic	36.3%
18	Cerebellar Diseases	36.3%
19	Encephalitis	36.3%
20	Encephalomalacia	36.3%
21	Epilepsy	36.3%
22	Hydrocephalus	36.3%
23	Congenital Hydrocephalus	36.3%
24	Hypothalamic Diseases	36.3%
25	Thalamic Diseases	36.3%
26	Intracranial Hypertension	36.3%
27	Aura	36.3%
28	Leukoencephalopathy	36.3%
29	Neuroaxonal Dystrophies	36.3%
30	Headache Disorders	36.3%
31	Intracranial Hypotension	36.3%
32	Brain Edema	36.3%
33	Brain Hypoxia	36.3%
34	Aqueductal Stenosis	36.3%
35	Myelitis	34.7%
36	Progressive supranuclear palsy	33.8%
37	Pneumocephalus	33.5%
38	Neuroleptic Malignant Syndrome	33.3%
39	Posterior Leukoencephalopathy Syndrome	33.2%
40	Posterior reversible encephalopathy syndrome	33.2%
41	Huntington Disease	33.2%
42	Asterixis	32.2%
43	Ballismus	32.2%
44	Shy-Drager Syndrome	32.2%
45	Dandy-Walker Syndrome	31.5%
46	Ocular Motility Disorders	31.2%
47	Cyclophoria	31.2%
48	Epidural Abscess	31.1%
49	Cerebral Ventriculitis	30.9%
50	Dementia, Vascular	30.3%
51	Brain Abscess	30%
52	Central Nervous System Infection	29.2%
53	Myoclonic Epilepsy	29%
54	Epilepsy, Temporal Lobe	29%
55	Epilepsy, Rolandic	29%
56	Benign Rolandic Epilepsy	29%
57	Marchiafava-Bignami Disease	28.3%
58	Brain Diseases, Metabolic	27.7%
59	Cerebrovascular Disorders	27.7%
60	Cerebrovascular Insufficiency	27.7%
61	Dementia	27.7%
62	Epilepsy, Post-Traumatic	27.6%
63	Prion Diseases	26.9%
64	Vascular Headaches	26.7%
65	Hypoxia-Ischemia, Brain	26.5%
66	Brain Injuries	26.5%
67	Brain Neoplasms	26.3%
68	Hepatolenticular Degeneration	25.5%
69	Basal Ganglia Hemorrhage	25.4%
70	Leukomalacia, Periventricular	25.1%
71	Cerebral Palsy	25%
72	Epilepsies, Partial	25%
73	Epilepsy, Generalized	25%
74	Pseudotumor Cerebri	25%
75	Hypertensive Encephalopathy	25%
76	Simple Partial Seizures	25%
77	Epilepsy, Reflex	25%
78	Headache Disorders, Primary	25%
79	Headache Disorders, Secondary	25%
80	Medication overuse headache	25%
81	Juvenile Myoclonic Epilepsy	24.9%
82	Myoclonic Epilepsies, Progressive	24.9%
83	Creutzfeldt-Jakob disease	24.8%
84	Stiff-Person Syndrome	24.3%
85	Cerebellar Neoplasms	24.1%
86	Brain Death	23.9%
87	Meningitis, Bacterial	23.7%
88	Meningitis, Fungal	23.7%
89	Spinal Muscular Atrophy	23.2%
90	Progressive Muscular Atrophy	23.2%
91	Arachnoiditis	23.1%
92	Aseptic Meningitis	23.1%
93	Syringomyelia	23.1%
94	Pneumorrhachis	23.1%
95	Akathisia, Drug-Induced	23%
96	Myelinolysis, Central Pontine	22.7%
97	Poliomyelitis	22.5%
98	Spinal Cord Injuries	22.4%
99	Cranial nerve diseases	22.4%
100	Demyelinating Diseases	22.4%
101	Demyelination	22.4%
102	Neuromuscular Diseases	22.4%
103	Chronobiology Disorders	22.4%
104	Lewy Body Disease	22.4%
105	Chorea	22.2%
106	Leukoencephalopathy, Progressive Multifocal	22.2%
107	Putaminal Hemorrhage	22%
108	Lupus Vasculitis, Central Nervous System	21.2%
109	Limbic Encephalitis	21%
110	Amblyopia	20.9%
111	Torticollis	20.7%
112	Subacute Combined Degeneration	20.6%
113	Brain Diseases	20.2%
114	Pituitary Diseases	19.8%
115	Amyotrophic Lateral Sclerosis	19.8%
116	Presenile dementia	19.7%
117	Senile dementia	19.7%
118	Pituitary Apoplexy	19.7%
119	Post-Traumatic Headache	19.5%
120	Tension Headache	19.5%
121	Epilepsy, Complex Partial	19.5%
122	Migraine Disorders	19.5%
123	Abdominal Migraine	19.5%
124	Status Migrainosus	19.5%
125	Cervicogenic Headache	19.5%
126	Brain Infarction	19.4%
127	Lafora Disease	19.2%
128	Unverricht-Lundborg Syndrome	19.2%
129	Carotid Artery Diseases	18.9%
130	Brain Ischemia	18.9%
131	Cerebrovascular accident	18.9%
132	Kluver-Bucy Syndrome	18.9%
133	Vasospasm, Intracranial	18.9%
134	Intracranial Arterial Diseases	18.9%
135	Dyskinesia, Drug-Induced	18.8%
136	Motor Neuron Disease	18.8%
137	Chronic Fatigue Syndrome	18.7%
138	Leukoencephalitis, Acute Hemorrhagic	18.6%
139	Spinal Cord Neoplasms	18.4%
140	Brain Injuries, Diffuse	18.2%
141	Traumatic Brain Injury	18.2%
142	Cerebellar Ataxia	18.1%
143	Supratentorial Neoplasms	18.1%
144	Toxoplasmosis, Cerebral	18.1%
145	Pituitary Adenoma	18%
146	Pituitary Neoplasms	18%
147	Tuberculosis, Meningeal	17.9%
148	Central Nervous System Fungal Infections	17.6%
149	Conus Medullaris Syndrome	17.6%
150	Spinal Cord Vascular Diseases	17.6%
151	Friedreich Ataxia	17.6%
152	Infarction, Middle Cerebral Artery	17.5%
153	Infarction, Anterior Cerebral Artery	17.5%
154	Infarction, Posterior Cerebral Artery	17.5%
155	Carotid Artery Injuries	17.5%
156	Ophthalmoplegic Migraine	17.4%
157	Encephalomyelitis, Acute Disseminated	17.4%
158	Trauma, Nervous System	17.4%
159	Tardive Dyskinesia	17.4%
160	Persistent Vegetative State	17.4%
161	Brain Hemorrhage, Traumatic	17.4%
162	Amnesia, Transient Global	17.2%
163	Movement Disorders	16.9%
164	Nervous System Neoplasms	16.8%
165	Neurologic Manifestations	16.8%
166	Neurotoxicity Syndromes	16.8%
167	Myelitis, Transverse	16.7%
168	Cluster Headache	16.7%
169	Migraine with Aura	16.7%
170	Familial Hemiplegic Migraine	16.7%
171	Chronic Paroxysmal Hemicrania	16.7%
172	SUNCT Syndrome	16.7%
173	Paroxysmal Hemicrania	16.7%
174	Cerebral Infarction	16.5%
175	Brain Stem Infarctions	16.5%
176	Paraneoplastic Cerebellar Degeneration	16.4%
177	Vasculitis, Central Nervous System	16.2%
178	Parkinson Disease	16.2%
179	Miller Fisher Syndrome	15.8%
180	Moyamoya Disease	15.5%
181	Canavan Disease	15.4%
182	Alexander Disease	15.4%
183	Polyradiculoneuropathy	15.2%
184	Polyradiculoneuritis	15.2%
185	Lateral Medullary Syndrome	15.1%
186	Reye Syndrome	15.1%
187	Autonomic Dysreflexia	15.1%
188	Complex Regional Pain Syndromes	15.1%
189	Intracranial Embolism and Thrombosis	15%
190	Hepatic Encephalopathy	15%
191	Restless Legs Syndrome	15%
192	Empty Sella Syndrome	14.9%
193	Hyperpituitarism	14.9%
194	Hypopituitarism	14.9%
195	Hypophysitis	14.9%
196	Opsoclonus-Myoclonus Syndrome	14.8%
197	Parkinsonian Disorders	14.8%
198	Scrapie	14.7%
199	Central Cord Syndrome	14.7%
200	Meningitis, Cryptococcal	14.6%
201	Cerebral Arterial Diseases	14.6%
202	Vertebrobasilar Insufficiency	14.6%
203	Basilar Artery Stenosis	14.6%
204	Vertebral Artery Stenosis	14.6%
205	Intracranial Hemorrhage, Hypertensive	14.6%
206	Transient Cerebral Ischemia	14.6%
207	Meningitis, Listeria	14.6%
208	Meningitis, Haemophilus	14.5%
209	Meningitis, Pneumococcal	14.5%
210	Subacute Sclerosing Panencephalitis	14.4%
211	Central Nervous System Bacterial Infections	14.3%
212	Diffuse Axonal Injury	14.1%
213	Brain Stem Neoplasms	14.1%
214	Sleep Wake Disorders	13.7%
215	Basal Ganglia Diseases	13.2%
216	Mitochondrial Encephalomyopathies	13.1%
217	Subarachnoid Hemorrhage, Traumatic	12.8%
218	Carotid Artery, Internal, Dissection	12.8%
219	Brain Diseases, Metabolic, Inborn	12.6%
220	Hyperprolactinemia	12.6%
221	Subclavian Steal Syndrome	12.5%
222	Pick Disease of the Brain	12.5%
223	Frontotemporal dementia	12.4%
224	Dysautonomia	12.4%
225	Vagus Nerve Disorder	12.4%
226	Glossopharyngeal Neuralgia	12.4%
227	Abducens Nerve Diseases	12.4%
228	Heavy Metal Poisoning, Nervous System	12.4%
229	Neuromuscular Junction Diseases	12.4%
230	Tauopathies	12.4%
231	Trochlear Nerve Diseases	12.4%
232	Peripheral Nervous System Diseases	12.4%
233	Spinal Cord Ischemia	12.3%
234	Peripheral Nerve Injuries	12.2%
235	MPTP Poisoning	12.2%
236	Choroid Plexus Papilloma	12.2%
237	Tuberculosis, Central Nervous System	12.1%
238	Myasthenia Gravis	12.1%
239	Brain Contusion	11.9%
240	Carotid Stenosis	11.7%
241	Intracranial Aneurysm	11.7%
242	Guillain-Barre Syndrome	11.7%
243	MELAS Syndrome	11.7%
244	Vertebral Artery Dissection	11.7%
245	Intracranial Arteriosclerosis	11.7%
246	Cerebral Atherosclerosis	11.7%
247	Subarachnoid Hemorrhage	11.7%
248	Cerebral Arteriosclerosis	11.7%
249	Cerebral Hemorrhage	11.7%
250	Cerebral Thrombosis	11.6%
251	Intracranial Embolism	11.6%
252	Intracranial Thrombosis	11.6%
253	Progressive bulbar palsy	11.6%
254	Bulbar palsy	11.6%
255	West Nile Fever	11.4%
256	Auditory Perceptual Disorders	11.4%
257	Adrenoleukodystrophy	11.2%
258	Ataxia Telangiectasia	11.2%
259	Causalgia	11.1%
260	Brain Concussion	10.9%
261	Wernicke Encephalopathy	10.8%
262	AIDS Dementia Complex	10.7%
263	Lambert-Eaton Myasthenic Syndrome	10.4%
264	Sleep Disorders, Circadian Rhythm	10.4%
265	Olfactory Nerve Injuries	10.4%
266	Alice in Wonderland Syndrome	10.3%
267	Acromegaly	10.1%
268	Botulism	10%
269	Central Nervous System Cysts	10%
270	Cerebral Amyloid Angiopathy	10%
271	Sinus Thrombosis, Intracranial	9.9%
272	Neuroaspergillosis	9.9%
273	Reflex Sympathetic Dystrophy	9.8%
274	Nocturnal Myoclonus Syndrome	9.8%
275	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.8%
276	Myopathy	9.7%
277	Optic Neuropathy	9.7%
278	Anterior Spinal Artery Syndrome	9.7%
279	Carotid Artery Thrombosis	9.7%
280	Kernicterus	9.6%
281	Neuromyelitis Optica	9.5%
282	Facial Nerve Diseases	9.4%
283	Craniocerebral Trauma	9.4%
284	Parasomnia	9.4%
285	Dyssomnias	9.4%
286	Vestibulocochlear Nerve Diseases	9.2%
287	Decerebrate State	9.2%
288	Hemiparesis	9.2%
289	Hydranencephaly	9.2%
290	Meningism	9.2%
291	Neural Tube Defects	9.2%
292	Paresis	9.2%
293	Seizures	9.2%
294	Sensation Disorders	9.2%
295	Tethered Cord Syndrome	9.2%
296	Central Nervous System Neoplasms	9.2%
297	Complex partial seizures	9.2%
298	Iniencephaly	9.2%
299	Craniorachischisis	9.2%
300	Exencephaly	9.2%
301	Monoparesis	9.2%
302	Septo-Optic Dysplasia	9.2%
303	Cortical Dysplasia	9.2%
304	Neurogenic Inflammation	9.2%
305	Gait Disorders, Neurologic	9.2%
306	Neuromuscular Manifestations	9.2%
307	Malformations of Cortical Development	9.2%
308	Multiple Sclerosis	9.2%
309	Sweating, Gustatory	9.2%
310	Auriculotemporal Syndrome	9.2%
311	Cavernous Sinus Thrombosis	9.1%
312	Sagittal Sinus Thrombosis	9.1%
313	Giant Cell Arteritis	9%
314	Temporal Arteritis	9%
315	Facial Nerve Injuries	8.9%
316	Horner Syndrome	8.8%
317	Pseudorabies	8.6%
318	Refsum Disease	8.5%
319	Hematoma, Subdural	8.3%
320	Hematoma, Epidural, Cranial	8.3%
321	Brachial Plexus Neuritis	8.1%
322	Neuralgic Amyotrophy	8.1%
323	Neurosyphilis	8.1%
324	Toxoplasmosis, Congenital	7.9%
325	Malaria, Cerebral	7.9%
326	Acrodynia	7.8%
327	Neurocysticercosis	7.8%
328	Ophthalmoplegia	7.8%
329	External Ophthalmoplegia	7.8%
330	Myasthenia Gravis, Autoimmune, Experimental	7.8%
331	Neuritis	7.7%
332	Polyneuritis	7.7%
333	Pupil Disorders	7.7%
334	Radiculitis	7.7%
335	Polyneuropathy	7.7%
336	Mononeuritis	7.7%
337	Mononeuropathies	7.7%
338	Neurobehavioral Manifestations	7.7%
339	Brachial Plexus Neuropathies	7.7%
340	Radiculopathy	7.7%
341	Mononeuropathy Multiplex	7.7%
342	Nerve Root Compression	7.7%
343	Nelson Syndrome	7.6%
344	Jet Lag Syndrome	7.6%
345	Paraneoplastic Encephalomyelitis	7.5%
346	Charcot-Marie-Tooth Disease	7.4%
347	Uveomeningoencephalitic Syndrome	7.4%
348	Fabry Disease	7.3%
349	Sturge-Weber Syndrome	7.3%
350	Vertigo	7.3%
351	Alcohol-Induced Disorders, Nervous System	7.3%
352	Tarsal Tunnel Syndrome	7.3%
353	Cauda Equina Syndrome	7.3%
354	Hematoma, Subdural, Intracranial	7.3%
355	Hematoma, Subdural, Chronic	7.3%
356	Hematoma, Subdural, Acute	7.3%
357	Galactosemias	7.3%
358	Urea Cycle Disorders, Inborn	7.3%
359	Tyrosinemias	7.3%
360	Prolactinoma	7.2%
361	Growth Hormone-Secreting Pituitary Adenoma	7.2%
362	Tuberous Sclerosis	7.1%
363	Lyme Neuroborreliosis	6.9%
364	Coma, Post-Head Injury	6.9%
365	Vocal Cord Paralysis	6.7%
366	Waterhouse-Friderichsen Syndrome	6.6%
367	Myotonia Congenita	6.6%
368	Cerebrospinal Fluid Otorrhea	6.5%
369	Cerebrospinal Fluid Rhinorrhea	6.5%
370	Neuritis, Autoimmune, Experimental	6.5%
371	Homocystinuria	6.5%
372	Gait Ataxia	6.5%
373	Multiple Sclerosis, Chronic Progressive	6.5%
374	Multiple Sclerosis, Relapsing-Remitting	6.5%
375	Leigh Disease	6.5%
376	Voice Disorders	6.3%
377	Voice Disturbance	6.3%
378	Smith-Magenis syndrome	6.1%
379	Dural Arteriovenous Fistula	6.1%
380	Menkes Kinky Hair Syndrome	5.9%
381	Myositis	5.9%
382	Optic Atrophy	5.9%
383	Optic Neuritis	5.9%
384	Papilledema	5.9%
385	Strabismus	5.9%
386	Tolosa-Hunt Syndrome	5.9%
387	Isaacs syndrome	5.9%
388	Arsenic Poisoning	5.9%
389	Myotonic Disorders	5.9%
390	Myasthenic Syndromes, Congenital	5.9%
391	Carpal Tunnel Syndrome	5.9%
392	Myotonic Dystrophy	5.8%
393	neurofibroma	5.8%
394	Sciatica	5.8%
395	Diabetic Neuropathies	5.8%
396	Facial Injuries	5.8%
397	Facial Neuralgia	5.8%
398	Diabetic Amyotrophy	5.8%
399	Diabetic Autonomic Neuropathy	5.8%
400	Sleep Talking	5.8%
401	Manganese Poisoning	5.8%
402	Sleep Disorders, Intrinsic	5.8%
403	Orthostatic intolerance	5.8%
404	Anosmia	5.7%
405	Ataxia	5.7%
406	Athetosis	5.7%
407	Catalepsy	5.7%
408	Dystonia	5.7%
409	Hemiplegia	5.7%
410	Locked-In Syndrome	5.7%
411	Meningeal Neoplasms	5.7%
412	Meningomyelocele	5.7%
413	Muscle Hypertonia	5.7%
414	Muscle hypotonia	5.7%
415	Myoclonus	5.7%
416	Myotonia	5.7%
417	Neuralgia	5.7%
418	Paraplegia	5.7%
419	Pseudobulbar Palsy	5.7%
420	Quadriplegia	5.7%
421	Spasm	5.7%
422	Spastic Paraplegia	5.7%
423	Status Epilepticus	5.7%
424	Taste Disorders	5.7%
425	Tremor	5.7%
426	Spina Bifida	5.7%
427	Monoplegia	5.7%
428	Hypokinesia	5.7%
429	Paraparesis	5.7%
430	Bradykinesia	5.7%
431	Waxy flexibility	5.7%
432	Action Tremor	5.7%
433	Resting Tremor	5.7%
434	Dysosmia	5.7%
435	Quadriparesis	5.7%
436	Mercury Poisoning, Nervous System	5.7%
437	Olfaction Disorders	5.7%
438	Myokymia	5.7%
439	Lead Poisoning, Nervous System	5.7%
440	Vestibular Neuronitis	5.7%
441	Somatosensory Disorders	5.7%
442	Neuropathic pain	5.7%
443	Hyperkinesia	5.7%
444	Intention tremor	5.7%
445	Alcohol Withdrawal Seizures	5.7%
446	Akathisia	5.6%
447	Restlessness	5.6%
448	Psychomotor Agitation	5.6%
449	Carbamoyl-Phosphate Synthase I Deficiency Disease	5.5%
450	Sciatic Neuropathy	5.4%
451	Ulnar Neuropathies	5.4%
452	Lesion of Sciatic Nerve	5.4%
453	Ulnar Neuritis	5.4%
454	Radial nerve compression	5.4%
455	Radial Tunnel Syndrome	5.4%
456	Peroneal Neuropathies	5.4%
457	Radial Neuropathy	5.4%
458	Median Neuropathy	5.4%
459	Sciatic Nerve Palsy	5.4%
460	Femoral Neuropathy	5.4%
461	Tibial Neuropathy	5.4%
462	Ulnar Nerve Palsy	5.4%
463	Postural Orthostatic Tachycardia Syndrome	5.4%
464	Radial nerve palsy	5.4%
465	Reflex, Abnormal	5.2%
466	Hyporeflexia	5.2%
467	Hyperreflexia	5.2%
468	Cubital Tunnel Syndrome	5.2%
469	Gait Apraxia	5.1%
470	Optic Nerve Glioma	5.1%
471	Glycogen storage disease type II	4.9%
472	Zellweger Syndrome	4.9%
473	Hand-Arm Vibration Syndrome	4.9%
474	Vision Disorders	4.8%
475	Metamorphopsia	4.8%
476	Visual Impairment	4.8%
477	Fibromyalgia	4.8%
478	Optic Neuropathy, Ischemic	4.8%
479	Anterior Ischemic Optic Neuropathy	4.8%
480	Medial Tibial Stress Syndrome	4.8%
481	Alstrom Syndrome	4.7%
482	Facial Hemiatrophy	4.7%
483	Melkersson-Rosenthal Syndrome	4.7%
484	Mitochondrial Myopathies	4.7%
485	Anisocoria	4.7%
486	Confusion	4.7%
487	Facial paralysis	4.7%
488	Lethargy	4.7%
489	Memory Disorders	4.7%
490	Muscle Cramp	4.7%
491	Perceptual Disorders	4.7%
492	Psychomotor Disorders	4.7%
493	Tonic Pupil	4.7%
494	Eosinophilia-Myalgia Syndrome	4.7%
495	Anhedonia	4.7%
496	Disorientation	4.7%
497	Facial Paresis	4.7%
498	Memory Loss	4.7%
499	Hemisensory Neglect	4.7%
500	Dysacusis	4.7%
501	Sleep Bruxism	4.6%
502	Anencephaly	4.6%
503	Meningocele	4.6%
504	Muscular Atrophy	4.6%
505	Respiratory Paralysis	4.6%
506	Encephalocele	4.6%
507	Tetany	4.6%
508	Amyloid Neuropathies, Familial	4.3%
509	Polyradiculopathy	4.3%
510	Thoracic Outlet Syndrome	4.2%
511	Acoustic Neuroma	4.1%
512	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
513	Gaucher Disease	4.1%
514	Esotropia	4.1%
515	Exotropia	4.1%
516	Hypotension, Orthostatic	4.1%
517	Sleep Apnea Syndromes	4.1%
518	Polymyositis	4.1%
519	Post-Exercise Hypotension	4.1%
520	Disorders of Excessive Somnolence	4.1%
521	Sleep Initiation and Maintenance Disorders	4.1%
522	Night Terrors	4.1%
523	Somnambulism	4.1%
524	Trigeminal Nerve Disorder	4.1%
525	Transient Insomnia	4.1%
526	Sleep Paralysis	4.1%
527	Chronic Insomnia	4.1%
528	REM Sleep Behavior Disorder	4.1%
529	Hypersomnia	4.1%
530	Dermal Sinus	4%
531	Dysgeusia	4%
532	Formication	4%
533	Hyperalgesia	4%
534	Hyperesthesia	4%
535	Hypesthesia	4%
536	Language Disorders	4%
537	Numbness	4%
538	Paresthesia	4%
539	Paraparesis, Spastic	4%
540	Spina Bifida Cystica	4%
541	Trismus	4%
542	Spina Bifida Occulta	4%
543	Epilepsia Partialis Continua	4%
544	Hypogeusia	4%
545	Meningeal Carcinomatosis	4%
546	Brown-Sequard Syndrome	4%
547	Lissencephaly	4%
548	Polymicrogyria	4%
549	Pachygyria	4%
550	Schizencephaly	4%
551	Lockjaw	4%
552	Allodynia	4%
553	Lead Poisoning, Nervous System, Childhood	4%
554	Lead Poisoning, Nervous System, Adult	4%
555	Periventricular Nodular Heterotopia	4%
556	Ageusia	4%
557	Duane Retraction Syndrome	4%
558	Consciousness Disorders	3.9%
559	Mental Retardation	3.9%
560	Muscle Weakness	3.9%
561	Depressed Level of Consciousness	3.9%
562	Mental deficiency	3.9%
563	Intellectual Disability	3.9%
564	Mobius Syndrome	3.9%
565	Bell Palsy	3.9%
566	Catatonia	3.9%
567	Herpes Zoster Oticus	3.9%
568	Familial Periodic Paralysis	3.9%
569	Aphonia	3.8%
570	Sleep Deprivation	3.8%
571	Dysphonia	3.8%
572	Tay-Sachs Disease	3.8%
573	Alexia	3.7%
574	Dyslexia	3.7%
575	Niemann-Pick Disease, Type C	3.6%
576	Neurofibrosarcoma	3.4%
577	Eye Injuries	3.4%
578	Muscular Dystrophy	3.3%
579	Congenital nystagmus	3.3%
580	Orbital Myositis	3.3%
581	Diplopia	3.3%
582	Muscle Rigidity	3.3%
583	Muscle Spasticity	3.3%
584	Scotoma	3.3%
585	Photophobia	3.3%
586	Cogwheel Rigidity	3.3%
587	Hemifacial Spasm	3.3%
588	Amaurosis	3.3%
589	Blindness	3.3%
590	Nuchal Rigidity	3.3%
591	Myalgia	3.3%
592	Pyomyositis	3.3%
593	Agnosia	3.3%
594	Apraxias	3.3%
595	Hallucinations	3.3%
596	Hemianopsia	3.3%
597	Hyperacusis	3.3%
598	Tinnitus	3.3%
599	Visual Agnosia	3.3%
600	Anosognosia	3.3%
601	Wernicke-Korsakoff Syndrome	3.3%
602	Phonophobia	3.3%
603	Hearing Loss	3.3%
604	Neuronal Ceroid-Lipofuscinoses	3.3%
605	Optic Atrophy, Hereditary, Leber	3.3%
606	Sleep Apnea, Obstructive	3.2%
607	Sleep Apnea, Central	3.2%
608	Sarcopenia	3.2%
609	Narcolepsy	3.2%
610	Trigeminal Neuralgia	3.2%
611	Kleine-Levin Syndrome	3.2%
612	Kearns-Sayre syndrome	3.2%
613	Agraphia	3.2%
614	Anomia	3.2%
615	Cluttering	3.2%
616	Language Development Disorders	3.2%
617	Speech Disorders	3.2%
618	Syncope	3.2%
619	Stupor	3.2%
620	Dysgraphia	3.2%
621	Presyncope	3.2%
622	Dyslalia	3.2%
623	Aicardi's syndrome	2.9%
624	Hoarseness	2.9%
625	Cockayne Syndrome	2.9%
626	Alcohol Withdrawal Delirium	2.9%
627	Cataplexy	2.8%
628	Aphasia	2.8%
629	Articulation Disorders	2.8%
630	Echolalia	2.8%
631	Stuttering	2.8%
632	Dysphasia	2.8%
633	Amnesia	2.8%
634	Delirium	2.8%
635	Dissociative Amnesia	2.8%
636	Color blindness	2.8%
637	Global Amnesia	2.8%
638	Cri-du-Chat Syndrome	2.7%
639	Down Syndrome	2.7%
640	Trisomy 21	2.7%
641	POEMS Syndrome	2.7%
642	Meningioma	2.7%
643	Williams Syndrome	2.7%
644	Microcephaly	2.7%
645	Macrocephaly	2.7%
646	Hypokalemic periodic paralysis	2.7%
647	Porencephaly	2.7%
648	Eye Burns	2.6%
649	Welander Distal Myopathy	2.6%
650	Dysarthria	2.6%
651	Amaurosis Fugax	2.6%
652	Blindness, Cortical	2.6%
653	Dyscalculia	2.6%
654	Rett Syndrome	2.6%
655	Deafness	2.6%
656	Hearing Loss, Sudden	2.6%
657	Gerstmann Syndrome	2.6%
658	Hearing Loss, Bilateral	2.6%
659	Hearing Loss, High-Frequency	2.6%
660	Hearing Loss, Mixed Conductive-Sensorineural	2.6%
661	Prosopagnosia	2.6%
662	Apraxia, Ideomotor	2.6%
663	Charles Bonnet Syndrome	2.6%
664	Hearing Loss, Unilateral	2.6%
665	Complete Hearing Loss	2.6%
666	Alien Hand Syndrome	2.6%
667	Deaf Mutism	2.6%
668	Holoprosencephaly	2.6%
669	Prader-Willi Syndrome	2.3%
670	Phantom pain	2.3%
671	Phantom Limb Pain	2.3%
672	Mutism	2.3%
673	Selective Mutism	2.3%
674	Dermatomyositis	2.2%
675	Corneal Scar	2.2%
676	Muscular Dystrophy, Duchenne	2.2%
677	Retrograde amnesia	2.2%
678	Amnesia, Anterograde	2.2%
679	Alexia, Pure	2.1%
680	Corneal Perforation	1.9%
681	Fragile X Syndrome	1.8%
682	Rubinstein-Taybi Syndrome	1.8%
683	Mucopolysaccharidosis II	1.3%

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