MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Renal tubular acidosis

(UMLS:C0001126)

Definition:: A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
UMLS ID:: C0001126
MeSH ID:: D000141

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.815.093

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.815.093

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.861.093

Classification 4:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.076.176.210|C18.452.648.861.093

Synonym(s)

Renal tubular acidosis

ACIDOSIS, RENAL HYPERCHLOREMIC

Accumulation of acid in body due to kidney problem

RENAL TUBULAR ACIDOSIS

RTA - Renal tubular acidosis

RTA, NOS

Renal Tubular Acidosis

Renal tubular acidosis, NOS

acidosis renal tubules

10.

acidosis tubular renal

11.

renal tubular acidosis

12.

renal tubule acidosis

13.

rta

14.

tubular acidosis; renal

15.

tubular renal acidosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Topiramate	FAERS: 68	OFFSIDES SIDER US FAERS
2	Ibuprofen	FAERS: 45 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Deferasirox	FAERS: 36 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
4	Lisinopril	FAERS: 21	US FAERS
5	Levetiracetam	FAERS: 10	US FAERS
6	Tenofovir	FAERS: 10	OFFSIDES US FAERS
7	Diclofenac	FAERS: 9	US FAERS
8	Paroxetine	FAERS: 9	US FAERS
9	Acetaminophen	FAERS: 7	US FAERS
10	Tacrolimus	FAERS: 7	US FAERS
11	Tenofovir	FAERS: 7	OFFSIDES US FAERS
12	adefovir dipivoxil	FAERS: 7	OFFSIDES US FAERS
13	Canagliflozin	FAERS: 6	US FAERS
14	Amlodipine	FAERS: 5	US FAERS
15	Octreotide	FAERS: 5	US FAERS
16	Zoledronic Acid	FAERS: 5	OFFSIDES US FAERS
17	Arthrotec	FAERS: 4	US FAERS
18	Capecitabine	FAERS: 4	US FAERS
19	Ifosfamide	FAERS: 4	SIDER US FAERS
20	Valproic Acid	FAERS: 4	US FAERS
21	Azacitidine	FAERS: 3	SIDER US FAERS
22	Foscarnet	FAERS: 3	US FAERS
23	Metformin	FAERS: 3	US FAERS
24	Methylphenidate	FAERS: 3	US FAERS
25	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 3	US FAERS
26	Valsartan	FAERS: 3	US FAERS
27	Acetazolamide	FAERS: 2	OFFSIDES US FAERS
28	Carboplatin	FAERS: 2	US FAERS
29	Cyclosporine	FAERS: 2	US FAERS
30	Furosemide	FAERS: 2	US FAERS
31	Irinotecan	FAERS: 2	US FAERS
32	Lenalidomide	FAERS: 2	OFFSIDES US FAERS
33	Losartan	FAERS: 2	US FAERS
34	Risperidone	FAERS: 2	US FAERS
35	Valproic Acid	FAERS: 2	OFFSIDES US FAERS
36	aliskiren	FAERS: 2	US FAERS
37	liposomal amphotericin B	FAERS: 2	SIDER US FAERS
38	Alendronate	FAERS: 1	US FAERS
39	Celecoxib	FAERS: 1	US FAERS
40	Cidofovir	FAERS: 1	US FAERS
41	Citalopram	FAERS: 1	US FAERS
42	Clonidine	FAERS: 1	US FAERS
43	Dactinomycin	FAERS: 1	US FAERS
44	Daptomycin	FAERS: 1	US FAERS
45	Docetaxel	FAERS: 1	US FAERS
46	Enalapril	FAERS: 1	US FAERS
47	Esomeprazole	FAERS: 1	US FAERS
48	Galantamine	FAERS: 1	US FAERS
49	Glatiramer Acetate	FAERS: 1	OFFSIDES US FAERS
50	Hydroxyurea	FAERS: 1	OFFSIDES US FAERS
51	Imatinib Mesylate	FAERS: 1	US FAERS
52	Insulin Glargine	FAERS: 1	US FAERS
53	LCZ 696	FAERS: 1	US FAERS
54	Lapatinib	FAERS: 1	US FAERS
55	Lithium Carbonate	FAERS: 1	US FAERS
56	Mycophenolic Acid	FAERS: 1	US FAERS
57	Pemetrexed	FAERS: 1	US FAERS
58	Sorafenib	FAERS: 1	US FAERS
59	Spironolactone	FAERS: 1	US FAERS
60	Telmisartan	FAERS: 1	US FAERS
61	Tigecycline	FAERS: 1	OFFSIDES US FAERS
62	Tobramycin	FAERS: 1	US FAERS
63	Viekira Pak	FAERS: 1	US FAERS
64	Zonisamide	FAERS: 1	SIDER US FAERS
65	anagrelide	FAERS: 1	US FAERS
66	apremilast	FAERS: 1	US FAERS
67	miglustat	FAERS: 1	US FAERS
68	telithromycin	FAERS: 1	OFFSIDES US FAERS
69	5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride		OFFSIDES
70	Amoxicillin		OFFSIDES
71	Ampicillin	Canada Vigilance: 1	Canada Vigilance
72	Bisacodyl		OFFSIDES
73	Bosentan		OFFSIDES
74	Cetirizine		OFFSIDES
75	Chlorhexidine		OFFSIDES
76	Codeine		OFFSIDES
77	Cyclizine		OFFSIDES
78	Didanosine		OFFSIDES
79	Domperidone		OFFSIDES
80	Doxazosin		OFFSIDES
81	Estramustine		OFFSIDES
82	Ethambutol		OFFSIDES
83	Famotidine		OFFSIDES
84	Fenofibrate		OFFSIDES
85	Fludrocortisone		OFFSIDES
86	Galactose		OFFSIDES
87	Galantamine		OFFSIDES
88	Gefitinib		OFFSIDES
89	Letrozole		OFFSIDES
90	Lopinavir/Ritonavir		OFFSIDES
91	Medroxyprogesterone Acetate		OFFSIDES
92	Medroxyprogesterone		OFFSIDES
93	Mesna		OFFSIDES
94	Methylprednisolone		OFFSIDES
95	Midazolam		OFFSIDES
96	Pamidronate		OFFSIDES
97	Panipenem-betamipron		OFFSIDES
98	Phentermine		OFFSIDES
99	Piperacillin, Tazobactam Drug Combination		OFFSIDES
100	Potassium Citrate		OFFSIDES
101	Prazosin		OFFSIDES
102	Promethazine		OFFSIDES
103	Pyridoxal Phosphate		OFFSIDES
104	Ramipril	Canada Vigilance: 1	Canada Vigilance
105	Rifabutin		OFFSIDES
106	Rifampin		OFFSIDES
107	Selenium		OFFSIDES
108	Sodium Bicarbonate		OFFSIDES
109	Streptozocin		SIDER
110	Sulfate		OFFSIDES
111	Tamoxifen		OFFSIDES
112	Timolol		OFFSIDES
113	Tretinoin		OFFSIDES
114	Vitamin K 1		OFFSIDES
115	abacavir		OFFSIDES
116	alfacalcidol		OFFSIDES
117	betamethasone-17,21-dipropionate		OFFSIDES
118	cefuroxime axetil		OFFSIDES
119	chlorhexidine gluconate		OFFSIDES
120	cyclobenzaprine		OFFSIDES
121	danthron		OFFSIDES
122	exemestane		OFFSIDES
123	miglitol		OFFSIDES
124	pimecrolimus		OFFSIDES
125	polystyrene sulfonic acid		OFFSIDES
126	posaconazole		SIDER
127	quazepam		OFFSIDES
128	tipranavir		OFFSIDES
129	valdecoxib		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperphosphaturia	46.4%
2	Renal Aminoacidurias	45.4%
3	Fanconi Syndrome	45.4%
4	Pseudohypoaldosteronism	45.4%
5	Liddle Syndrome	45.4%
6	Glycosuria, Renal	40.7%
7	Cystinuria	33.8%
8	Familial Hypophosphatemic Rickets	29.7%
9	Zellweger Syndrome	27.4%
10	Brain Diseases, Metabolic, Inborn	25%
11	Smith-Lemli-Opitz Syndrome	24.4%
12	Leigh Disease	24%
13	Amino Acid Metabolism, Inborn Errors	23.7%
14	Carbohydrate Metabolism, Inborn Errors	23.7%
15	Metal Metabolism, Inborn Errors	23.7%
16	Progeria	23.7%
17	Lysosomal Storage Diseases	23.7%
18	Peroxisomal Disorders	23.7%
19	Galactosemias	23.4%
20	Urea Cycle Disorders, Inborn	23.4%
21	Tyrosinemias	23.4%
22	Pseudohypoparathyroidism	22.8%
23	Anuria	22.7%
24	Nephrolithiasis	22.7%
25	Nephrocalcinosis	22.4%
26	Glycogen storage disease type II	21%
27	Carbamoyl-Phosphate Synthase I Deficiency Disease	20.8%
28	Hydronephrosis	20.1%
29	Hyperoxaluria	20.1%
30	Kidney Cortex Necrosis	20.1%
31	Kidney Papillary Necrosis	20.1%
32	Nephritis	20.1%
33	Nephrosclerosis	20.1%
34	Nephrosis	20.1%
35	Perinephritis	20.1%
36	Kidney Failure	20.1%
37	Uremia	20.1%
38	Oxalosis	20.1%
39	Renal Insufficiency	20.1%
40	Menkes Kinky Hair Syndrome	19.8%
41	Hyperhomocysteinemia	19.5%
42	Adrenoleukodystrophy	19.4%
43	Acidosis, Lactic	19.3%
44	Ketosis	19.3%
45	Ketonuria	19.3%
46	Ketoacidosis	19.3%
47	Ketonemia	19.3%
48	Homocystinuria	19.3%
49	Wasting Syndrome	18.9%
50	Renal Osteodystrophy	18.7%
51	Renal rickets	18.7%
52	Lactose Intolerance	18.7%
53	Hypolipoproteinemias	18.5%
54	Tuberculosis, Renal	18.3%
55	Gaucher Disease	18.2%
56	Hepatolenticular Degeneration	18.1%
57	Cytochrome-c Oxidase Deficiency	18.1%
58	Diabetes Insipidus	17.8%
59	Hepatorenal Syndrome	17.8%
60	Refsum Disease	17.7%
61	Diabetic Nephropathy	17.6%
62	Renal hypertension	17.6%
63	Renal Artery Obstruction	17.6%
64	Renal Artery Stenosis	17.6%
65	Hyperlipoproteinemia Type IV	17.4%
66	Hyperlipoproteinemia Type V	17.4%
67	Hyperlipidemia, Familial Combined	17.3%
68	Fabry Disease	16.7%
69	Hypercalcemia	16.7%
70	Hypocalcemia	16.7%
71	Milk-Alkali Syndrome	16.7%
72	Hyperlipoproteinemia Type III	16.6%
73	Acidosis, Respiratory	16.6%
74	Kidney Neoplasm	16.5%
75	Amyloid Neuropathies, Familial	16.4%
76	Calcium Metabolism Disorders	16.3%
77	Iron Metabolism Disorders	16.3%
78	Phosphorus Metabolism Disorders	16.3%
79	Water-Electrolyte Imbalance	16.3%
80	Lipid Metabolism Disorders	16.3%
81	Mitochondrial Diseases	16.3%
82	Glucose Metabolism Disorders	16.3%
83	Mucopolysaccharidosis III	16.3%
84	Alkalosis	16.2%
85	Diabetic Ketoacidosis	15.7%
86	Alkaptonuria	15.6%
87	Glycogen Storage Disease	15.6%
88	Hypophosphatasia	15.6%
89	Propionic acidemia	15.6%
90	Dihydropyrimidine Dehydrogenase Deficiency	15.6%
91	Cystinosis	15.6%
92	Mucopolysaccharidosis II	15.5%
93	Werner Syndrome	15.5%
94	Pyelonephritis	15.4%
95	Urinary Bladder Diseases	15.2%
96	Ureteral Diseases	15.2%
97	Urethral Diseases	15.2%
98	Urination Disorders	15.2%
99	Urolithiasis	15.2%
100	Glycosuria	15.2%
101	Tay-Sachs Disease	15.2%
102	Niemann-Pick Disease, Type C	15.1%
103	Neuronal Ceroid-Lipofuscinoses	15%
104	Polycystic Kidney Diseases	14.7%
105	Kidney Calculi	14.7%
106	Lipodystrophy	14.7%
107	Multicystic Dysplastic Kidney	14.5%
108	Albinism	14.2%
109	Osteopenia	14.2%
110	AIDS-Associated Nephropathy	14.1%
111	Ureterolithiasis	14.1%
112	Brain Diseases, Metabolic	14.1%
113	Achlorhydria	13.9%
114	Rickets	13.9%
115	Hypoalphalipoproteinemias	13.8%
116	Urinary tract infection	13.5%
117	Glomerulonephritis	13.3%
118	Nephritis, Interstitial	13.3%
119	Lipoid nephrosis	13.3%
120	Nephrotic Syndrome	13.3%
121	Pyelitis	13.3%
122	Pyonephrosis	13.3%
123	Nephrogenic Diabetes Insipidus	13.3%
124	Congenital Nephrogenic Diabetes Insipidus	13.3%
125	Acute kidney injury	13.3%
126	Ichthyosis, X-Linked	13.2%
127	MELAS Syndrome	12.6%
128	Pyelocystitis	12.4%
129	Familial Periodic Paralysis	12.3%
130	Sjogren-Larsson Syndrome	11.9%
131	Azotemia	11.8%
132	Urogenital Abnormalities	11.7%
133	Glycogen Storage Disease Type I	11.7%
134	Glycogen Storage Disease Type V	11.7%
135	Bladder neck obstruction	11.6%
136	Hypertension, Renovascular	11.6%
137	Antley-Bixler Syndrome Phenotype	11.6%
138	Cockayne Syndrome	11.6%
139	Bladder Exstrophy	11.5%
140	Epispadias	11.5%
141	Gout	11.1%
142	Canavan Disease	10.8%
143	Alexander Disease	10.8%
144	Nephroblastoma	10.7%
145	Congenital Hyperinsulinism	10.6%
146	Polycystic Kidney, Autosomal Dominant	10.6%
147	Ureteral Calculi	10.4%
148	Hemolytic-Uremic Syndrome	10.3%
149	Nutrition Disorders	10%
150	Balkan Nephropathy	9.9%
151	Focal glomerulosclerosis	9.9%
152	Kidney Failure, Chronic	9.9%
153	Mesoblastic Nephroma	9.9%
154	Renal Cell Carcinoma	9.9%
155	Papillary Renal Cell Carcinoma	9.9%
156	Porphyrias, Hepatic	9.9%
157	Bloom Syndrome	9.7%
158	Mitochondrial Encephalomyopathies	9.7%
159	Amyloidosis	9.7%
160	Calcinosis	9.7%
161	Hyperglycemia	9.7%
162	Hyperinsulinism	9.7%
163	Hyperkalemia	9.7%
164	Hypernatremia	9.7%
165	Hypoglycemia	9.7%
166	Hypokalemia	9.7%
167	Hyponatremia	9.7%
168	Xanthomatosis	9.7%
169	Hypophosphatemia	9.7%
170	Dyslipidemias	9.7%
171	Iron Overload	9.7%
172	Xanthoma	9.7%
173	Fanconi Anemia	9.7%
174	Osteomalacia	9.4%
175	Alkalosis, Respiratory	9.2%
176	Hypokalemic periodic paralysis	9.1%
177	Ataxia Telangiectasia	9.1%
178	Cystitis	9%
179	Ureteral obstruction	9%
180	Ureterocele	9%
181	Urethral Obstruction	9%
182	Urethritis	9%
183	Vesico-Ureteral Reflux	9%
184	Urinary Retention	9%
185	Glomerulonephritis, Membranoproliferative	9%
186	Urinary Bladder Fistula	8.8%
187	Bladder Neoplasm	8.8%
188	Ureteral Neoplasms	8.8%
189	Urethral Neoplasms	8.8%
190	Diabetes Mellitus	8.6%
191	Dehydration	8.4%
192	Lipomatosis	8.4%
193	Water Intoxication	8.4%
194	Osteoporosis	8.4%
195	Bone Demineralization, Pathologic	8.4%
196	Post-Traumatic Osteoporosis	8.4%
197	Celiac Disease	8.3%
198	Sprue, Tropical	8.3%
199	Steatorrhea	8.3%
200	Sprue	8.3%
201	Arthritis, Gouty	8.2%
202	Acid-Base Imbalance	8.2%
203	Optic Atrophy, Hereditary, Leber	8.1%
204	Bacteriuria	7.9%
205	Hematuria	7.9%
206	Oliguria	7.9%
207	Polyuria	7.9%
208	Proteinuria	7.9%
209	Pyuria	7.9%
210	Urinary Calculi	7.9%
211	Cystocele	7.9%
212	Urinary Incontinence	7.9%
213	Anti-Glomerular Basement Membrane Disease	7.9%
214	Lupus Nephritis	7.8%
215	HIV Wasting Syndrome	7.8%
216	Friedreich Ataxia	7.7%
217	Atypical Hemolytic Uremic Syndrome	7.7%
218	Xeroderma Pigmentosum	7.6%
219	Nesidioblastosis	7.5%
220	Aicardi's syndrome	7.5%
221	Cystic Fibrosis	7.5%
222	Mitochondrial Myopathies	7.4%
223	CHARGE Syndrome	7.4%
224	Myelinolysis, Central Pontine	7.4%
225	Reye Syndrome	7.3%
226	Hepatic Encephalopathy	7.3%
227	Neoplastic Syndromes, Hereditary	7.2%
228	Denys-Drash Syndrome	7.2%
229	Enuresis	7.1%
230	HIV-Associated Lipodystrophy Syndrome	7%
231	Multiple Epiphyseal Dysplasia	7%
232	Osteochondrodysplasias	7%
233	Pelger-Huet Anomaly	7%
234	Myasthenic Syndromes, Congenital	7%
235	Gestational Diabetes	6.8%
236	Hypospadias	6.8%
237	Nail-Patella Syndrome	6.6%
238	Wernicke Encephalopathy	6.6%
239	Necrobiosis Lipoidica Diabeticorum	6.5%
240	Fetal Diseases	6.5%
241	Anemia, Sickle Cell	6.5%
242	Thalassemia	6.5%
243	Muscular Dystrophy, Duchenne	6.5%
244	Variegate Porphyria	6.5%
245	Acute intermittent porphyria	6.5%
246	Porphyria Cutanea Tarda	6.5%
247	Calciphylaxis	6.4%
248	Hemosiderosis	6.4%
249	Vascular calcification	6.4%
250	Fragile X Syndrome	6.4%
251	Horseshoe Kidney	6.4%
252	Kallmann Syndrome	6.4%
253	Dwarfism	6.3%
254	Kernicterus	6.3%
255	Prader-Willi Syndrome	6.2%
256	Muscular Dystrophy	6.1%
257	Osteogenesis Imperfecta	6.1%
258	Beckwith-Wiedemann Syndrome	6.1%
259	Wolf-Hirschhorn Syndrome	6.1%
260	Urethral Stenosis	6%
261	Urethral stricture	6%
262	Infertility	5.9%
263	Alstrom Syndrome	5.8%
264	Kearns-Sayre syndrome	5.8%
265	Hermaphroditism	5.7%
266	Disorders of Sex Development	5.7%
267	Kartagener Syndrome	5.6%
268	Adiposis Dolorosa	5.5%
269	Autoimmune Lymphoproliferative Syndrome	5.5%
270	Insulin Resistance	5.5%
271	Marfan Syndrome	5.5%
272	Osteoporosis, Postmenopausal	5.5%
273	Smith-Magenis syndrome	5.5%
274	Child Nutrition Disorders	5.4%
275	Hypervitaminosis A	5.4%
276	Infant Nutrition Disorders	5.4%
277	Malnutrition	5.4%
278	Cri-du-Chat Syndrome	5.4%
279	Down Syndrome	5.4%
280	Angioedemas, Hereditary	5.4%
281	Trisomy 21	5.4%
282	Wiskott-Aldrich Syndrome	5.3%
283	Albuminuria	5.2%
284	Hemoglobinuria	5.2%
285	Urge Incontinence	5.2%
286	Holoprosencephaly	5.2%
287	Urologic Neoplasms	5.1%
288	Genital Diseases, Male	5%
289	Deformity	5%
290	Latent Autoimmune Diabetes in Adults	4.9%
291	Ectodermal Dysplasia	4.9%
292	Aplasia Cutis Congenita	4.9%
293	Diabetes Mellitus, Experimental	4.9%
294	Myotonic Dystrophy	4.9%
295	Acidosis	4.9%
296	Familial Mediterranean Fever	4.9%
297	Metabolic acidosis	4.9%
298	Tetany	4.8%
299	Rett Syndrome	4.8%
300	Hypercholesterolemia	4.8%
301	Hyperlipoproteinemias	4.8%
302	Hypertriglyceridemia	4.8%
303	Cerebral Amyloid Angiopathy	4.8%
304	Pregnancy Complications	4.7%
305	Sexually Transmitted Diseases	4.7%
306	Diurnal Enuresis	4.7%
307	Tuberous Sclerosis	4.6%
308	Rubinstein-Taybi Syndrome	4.6%
309	Genital Herpes	4.6%
310	Primary amyloidosis	4.3%
311	Williams Syndrome	4.3%
312	Sickle Cell Trait	4.3%
313	Chorioamnionitis	4.2%
314	Meconium Aspiration Syndrome	4.2%
315	Vesicovaginal Fistula	4.2%
316	Primary Ciliary Dyskinesia	4.2%
317	Genital Neoplasms, Male	4.1%
318	Endometriosis	4%
319	Uterine Diseases	4%
320	Vaginal Diseases	4%
321	Vulvar Diseases	4%
322	Endometrioma	4%
323	Cryptorchidism	4%
324	Retinal Dysplasia	4%
325	Aniridia	4%
326	Epidermolysis Bullosa	3.9%
327	Amyotrophic Lateral Sclerosis	3.9%
328	Renal tubular acidosis	3.9%
329	Turner Syndrome	3.8%
330	Cutis Laxa	3.7%
331	Retinitis Pigmentosa	3.7%
332	Pigmentary retinopathy	3.7%
333	Porokeratosis	3.7%
334	Keratoderma, Palmoplantar	3.7%
335	Chronic granulomatous disease	3.7%
336	Welander Distal Myopathy	3.6%
337	Uterine Neoplasms	3.6%
338	Vaginal Neoplasms	3.6%
339	Vulvar Neoplasms	3.6%
340	Uterine Cancer	3.6%
341	Acute Chest Syndrome	3.6%
342	CREST Syndrome	3.5%
343	Genital Neoplasms, Female	3.5%
344	Endometritis	3.4%
345	Gonadal Dysgenesis	3.4%
346	Adrenogenital Syndrome	3.4%
347	Ovotesticular Disorders of Sex Development	3.4%
348	Klinefelter Syndrome	3.3%
349	Duane Retraction Syndrome	3.3%
350	Pseudoxanthoma Elasticum	3.3%
351	Peutz-Jeghers Syndrome	3.3%
352	Myotonia Congenita	3.3%
353	Penile Neoplasms	3.3%
354	Prostatic Neoplasms	3.3%
355	Thrombasthenia	3.3%
356	Antithrombin III Deficiency	3.3%
357	Protein C Deficiency	3.3%
358	Afibrinogenemia	3.2%
359	Dystonia Musculorum Deformans	3.2%
360	Factor VII Deficiency	3.2%
361	Factor X Deficiency	3.2%
362	Factor XII Deficiency	3.2%
363	Hemophilia A	3.2%
364	Activated Protein C Resistance	3.2%
365	Factor II deficiency	3.2%
366	Factor VIII Deficiency	3.2%
367	Factor V deficiency	3.2%
368	Factor XI Deficiency	3.2%
369	Hypoprothrombinemias	3.2%
370	Deficiency Diseases	3.2%
371	Starvation	3.2%
372	Refeeding Syndrome	3.2%
373	Uterine Inversion	3.2%
374	Lafora Disease	3.2%
375	Unverricht-Lundborg Syndrome	3.2%
376	Anemia, Diamond-Blackfan	3.2%
377	Frontotemporal dementia	3.2%
378	Hyperandrogenism	3.2%
379	Fetal Growth Retardation	3.1%
380	Fetal Hypoxia	3.1%
381	Dyspareunia	3.1%
382	Fetal Alcohol Spectrum Disorders	3.1%
383	Fallopian Tube Neoplasms	3%
384	Multiple Endocrine Neoplasia	3%
385	Congenital Hypothyroidism	3%
386	Dermatitis, Atopic	2.9%
387	Xeroderma	2.9%
388	Mobius Syndrome	2.9%
389	Uterine Rupture	2.9%
390	Classical Lissencephalies and Subcortical Band Heterotopias	2.8%
391	Basal Cell Nevus Syndrome	2.8%
392	Hyperkeratosis, Epidermolytic	2.8%
393	Salpingitis	2.7%
394	Vulvovaginitis	2.7%
395	Abdominal Cramps	2.7%
396	Abnormalities, Drug-Induced	2.7%
397	Amniotic Band Syndrome	2.7%
398	Asphyxia Neonatorum	2.7%
399	Epididymitis	2.7%
400	Infant, Premature, Diseases	2.7%
401	Penile Diseases	2.7%
402	Prostatic Diseases	2.7%
403	Situs Inversus	2.7%
404	Spermatic Cord Torsion	2.7%
405	Hemospermia	2.7%
406	Infantile Colic	2.7%
407	Testicular Hydrocele	2.7%
408	Behcet Syndrome	2.7%
409	Charcot-Marie-Tooth Disease	2.6%
410	Polyhydramnios	2.5%
411	Obstetric Labor Complications	2.5%
412	Ectopic Pregnancy	2.5%
413	Pregnancy, Prolonged	2.5%
414	Puerperal Disorders	2.5%
415	Oligohydramnios	2.5%
416	Prenatal Injuries	2.5%
417	ovarian neoplasm	2.5%
418	Hydrops Fetalis	2.4%
419	Huntington Disease	2.4%
420	Oophoritis	2.4%
421	Papillon-Lefevre Disease	2.4%
422	Endometrial Hyperplasia	2.4%
423	Pyometra	2.4%
424	Vaginitis	2.4%
425	Vulvitis	2.4%
426	Vaginal Discharge	2.4%
427	Vulvodynia	2.4%
428	Eye Abnormalities	2.4%
429	Cardiovascular Abnormalities	2.4%
430	Endometrial Neoplasms	2.4%
431	Skin Abnormalities	2.4%
432	Testicular Diseases	2.4%
433	Varicocele	2.4%
434	Lymphatic Abnormalities	2.4%
435	Congenital Microtia	2.4%
436	Anemia, Neonatal	2.3%
437	Persistent Fetal Circulation Syndrome	2.3%
438	Spermatocele	2.3%
439	Congenital diaphragmatic hernia	2.3%
440	Umbilical hernia	2.3%
441	Abruptio Placentae	2.3%
442	Placenta Accreta	2.3%
443	Carcinoma, Endometrioid	2.2%
444	Pregnancy Complications, Cardiovascular	2.2%
445	Pregnancy Complications, Neoplastic	2.2%
446	Kwashiorkor	2.1%
447	Magnesium Deficiency	2.1%
448	Potassium Deficiency	2.1%
449	Protein Deficiency	2.1%
450	Avitaminosis	2.1%
451	Prostatic Neoplasms, Castration-Resistant	2.1%
452	Obesity	2.1%
453	Pregnancy Complications, Hematologic	2.1%
454	Pregnancy Complications, Infectious	2.1%
455	Fetal Death	2.1%
456	Perinatal death	2.1%
457	Ovarian Diseases	2.1%
458	Morning Sickness	2.1%
459	Neonatal Abstinence Syndrome	2.1%
460	Adnexitis	2.1%
461	Pruritus Vulvae	2.1%
462	Uterine hemorrhage	2.1%
463	Vaginal Fistula	2.1%
464	Pelvic Inflammatory Disease	2.1%
465	Adenomatous Polyposis Coli	2.1%
466	Uterine Prolapse	2.1%
467	Vaginal Prolapse	2.1%
468	Uterine Cervical Incompetence	2.1%
469	Congenital nystagmus	2%
470	Puerperal Infection	2%
471	Toxoplasmosis, Congenital	2%
472	Anencephaly	2%
473	Postpartum Hemorrhage	2%
474	Syphilis, Congenital	2%
475	Multiple Endocrine Neoplasia Type 1	2%
476	Maxillofacial Abnormalities	1.8%
477	Dural Arteriovenous Fistula	1.8%
478	Dextrocardia	1.8%
479	Candidiasis, Vulvovaginal	1.8%
480	Testicular Neoplasms	1.8%
481	Abnormalities, Radiation-Induced	1.6%
482	Balanitis	1.6%
483	Benign prostatic hypertrophy	1.6%
484	Phimosis	1.6%
485	Priapism	1.6%
486	prostatitis	1.6%
487	Prune Belly Syndrome	1.6%
488	Twins, Conjoined	1.6%
489	Prostatic Adenoma	1.6%
490	Benign Prostatic Hyperplasia	1.6%
491	Prostatic Hypertrophy	1.6%
492	Prostatic Hyperplasia	1.6%
493	Waardenburg Syndrome	1.6%
494	Chlamydia Infections	1.6%
495	Gonorrhea	1.6%
496	Ascorbic Acid Deficiency	1.6%
497	Uterine Cervicitis	1.6%
498	Leukorrhea	1.6%
499	Parametritis	1.6%
500	Vitamin A Deficiency	1.6%
501	Vitamin D Deficiency	1.6%
502	Vitamin E Deficiency	1.6%
503	Marasmus	1.6%
504	Obesity, Abdominal	1.6%
505	granulosa cell tumor	1.5%
506	Carcinoma, Ovarian Epithelial	1.5%
507	Scimitar Syndrome	1.5%
508	Ophthalmia Neonatorum	1.5%
509	Syphilis	1.5%
510	Pediatric Obesity	1.4%
511	Anophthalmos	1.4%
512	Anus, Imperforate	1.4%
513	Hydranencephaly	1.4%
514	Microphthalmos	1.4%
515	Neural Tube Defects	1.4%
516	Paralysis, Obstetric	1.4%
517	Premature Ejaculation	1.4%
518	Retinopathy of Prematurity	1.4%
519	Tethered Cord Syndrome	1.4%
520	Iniencephaly	1.4%
521	Craniorachischisis	1.4%
522	Limb Deformities, Congenital	1.4%
523	Erectile dysfunction	1.4%
524	Exencephaly	1.4%
525	Septo-Optic Dysplasia	1.4%
526	Craniofacial Abnormalities	1.4%
527	Cortical Dysplasia	1.4%
528	Malformations of Cortical Development	1.4%
529	Anorectal Malformations	1.4%
530	Bacterial Vaginosis	1.4%
531	Orchitis	1.4%
532	Bronchopulmonary Dysplasia	1.4%
533	Trichomonas Vaginitis	1.4%
534	Uterine Perforation	1.4%
535	Ovarian Hyperstimulation Syndrome	1.4%
536	Metrorrhagia	1.4%
537	Abortion, Habitual	1.3%
538	Dystocia	1.3%
539	Eclampsia	1.3%
540	Fetal Membranes, Premature Rupture	1.3%
541	Placental Insufficiency	1.3%
542	Pre-Eclampsia	1.3%
543	Prenatal Exposure Delayed Effects	1.3%
544	HELLP Syndrome	1.3%
545	Placenta, Retained	1.3%
546	Endometrial Stromal Sarcoma	1.3%
547	Folic Acid Deficiency	1.3%
548	Pellagra	1.3%
549	Thiamine Deficiency	1.3%
550	Vitamin B 12 Deficiency	1.3%
551	Vitamin B 6 Deficiency	1.3%
552	Pyridoxine Deficiency	1.3%
553	Craniosynostosis	1.3%
554	Syndactyly	1.3%
555	Brachycephaly	1.3%
556	Acrocephalosyndactylia	1.3%
557	Microcephaly	1.3%
558	Macrocephaly	1.3%
559	Blepharophimosis	1.2%
560	Laryngostenosis	1.2%
561	Mouth Abnormalities	1.2%
562	Respiratory Distress Syndrome, Newborn	1.2%
563	Esophageal Atresia	1.2%
564	Intestinal Atresia	1.2%
565	Pectus excavatum	1.2%
566	Klippel-Feil Syndrome	1.2%
567	Gastroschisis	1.2%
568	Synostosis	1.2%
569	Corpus Luteum Cyst	1.2%
570	Ovarian Cysts	1.2%
571	Acrodermatitis	1.2%
572	Lymphangiectasis, Intestinal	1.2%
573	Gianotti-Crosti Syndrome	1.2%
574	Vitamin K Deficiency	1.2%
575	Anovulation	1.2%
576	Menorrhagia	1.2%
577	Premature Menopause	1.2%
578	Beriberi	1.2%
579	Lymphogranuloma Venereum	1.2%
580	Abortion, Veterinary	1.2%
581	Pregnancy Complications, Parasitic	1.2%
582	Noonan Syndrome	1.2%
583	Lactation Disorder	1.2%
584	Mastitis	1.2%
585	Depression, Postpartum	1.2%
586	Embryo Loss	1.2%
587	Fetal Resorption	1.2%
588	Hyperemesis Gravidarum	1.2%
589	Arthrogryposis	1.1%
590	Choanal Atresia	1.1%
591	Tracheobronchomegaly	1.1%
592	Laryngocele	1.1%
593	Choledochal Cyst	1.1%
594	Cleft Palate	1.1%
595	Central Nervous System Cysts	1.1%
596	Dandy-Walker Syndrome	1.1%
597	Leukomalacia, Periventricular	1.1%
598	POEMS Syndrome	1.1%
599	Azoospermia	1.1%
600	Oligospermia	1.1%
601	Impotence, Vasculogenic	1.1%
602	Asthenozoospermia	1.1%
603	Teratozoospermia	1.1%
604	Aspermia	1.1%
605	Porencephaly	1.1%
606	Jaw Abnormalities	1%
607	Anemia, Pernicious	1%
608	Trophoblastic Neoplasms	1%
609	Embolism, Amniotic Fluid	1%
610	Breech Presentation	1%
611	Stillbirth	1%
612	Scurvy	1%
613	Laryngomalacia	1%
614	Pectus carinatum	1%
615	Poland Syndrome	1%
616	Amelia	0.9%
617	Arachnodactyly	0.9%
618	Ectopia Cordis	0.9%
619	Ectromelia	0.9%
620	Hemimelia	0.9%
621	Meningomyelocele	0.9%
622	Phocomelia	0.9%
623	Sirenomelia	0.9%
624	Spina Bifida	0.9%
625	Polydactyly	0.9%
626	Brachydactyly	0.9%
627	Plagiocephaly	0.9%
628	Lower Extremity Deformities, Congenital	0.9%
629	Upper Extremity Deformities, Congenital	0.9%
630	Single umbilical artery	0.9%
631	Polycystic Ovary Syndrome	0.9%
632	Aortic coarctation	0.8%
633	Cor Triatriatum	0.8%
634	Coronary Vessel Anomalies	0.8%
635	Dental Enamel Hypoplasia	0.8%
636	Patent ductus arteriosus	0.8%
637	Ebstein Anomaly	0.8%
638	Heart Septal Defects	0.8%
639	Hyaline Membrane Disease	0.8%
640	Hypodontia	0.8%
641	Macrostomia	0.8%
642	Meningocele	0.8%
643	Microstomia	0.8%
644	Tetralogy of Fallot	0.8%
645	Transposition of Great Vessels	0.8%
646	Hypoplastic Left Heart Syndrome	0.8%
647	May-Thurner Syndrome	0.8%
648	Encephalocele	0.8%
649	Craniofacial Dysostosis	0.8%
650	Micrognathism	0.8%
651	Pierre Robin Syndrome	0.8%
652	Wolff-Parkinson-White Syndrome	0.8%
653	Premature Birth	0.8%
654	Leydig Cell Tumor	0.8%
655	Subacute Combined Degeneration	0.7%
656	Retrognathia	0.7%
657	Long QT Syndrome	0.7%
658	Platybasia	0.7%
659	Tricuspid Atresia	0.7%
660	Arrhythmogenic Right Ventricular Dysplasia	0.7%
661	Bronchomalacia	0.7%
662	Tracheomalacia	0.7%
663	Galactorrhea	0.7%
664	Dermal Sinus	0.7%
665	Spina Bifida Cystica	0.7%
666	Spina Bifida Occulta	0.7%
667	Lissencephaly	0.7%
668	Polymicrogyria	0.7%
669	Pachygyria	0.7%
670	Schizencephaly	0.7%
671	Periventricular Nodular Heterotopia	0.7%
672	Prognathism	0.7%
673	Aortopulmonary Septal Defect	0.6%
674	Double Outlet Right Ventricle	0.6%
675	Endocardial Cushion Defects	0.6%
676	Myocardial bridging	0.6%
677	Aorticopulmonary Septal Defect	0.6%
678	Choriocarcinoma	0.5%
679	Mandibulofacial Dysostosis	0.5%
680	Romano-Ward Syndrome	0.5%
681	Truncus Arteriosus, Persistent	0.5%
682	Goldenhar Syndrome	0.5%
683	Talipes	0.4%
684	Arteriovenous fistula	0.4%
685	Hydatidiform Mole	0.4%
686	Congenital clubfoot	0.4%
687	Vertical Talus	0.4%

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