MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Reflex Sympathetic Dystrophy

(UMLS:C0034931)

Definition:: A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)
UMLS ID:: C0034931
MeSH ID:: D012019

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.177.195.800|C10.668.829.250.800

Synonym(s)

Reflex Sympathetic Dystrophy

CRPS (complex regional pain syndrome) type I

CRPS - Complex regional pain syndrome type I

Complex Regional Pain Syndrome I

Complex regional pain syndrome type 1

Complex regional pain syndrome type I

Dystrophy;reflex sympathetic

REFLEX SYMPATHETIC DYSTROPHY

RND

10.

RSD - Reflex sympathetic dystrophy

11.

Reflex sympathetic dystrophy

12.

Reflex sympathetic dystrophy syndrome

13.

Reflex sympathetic dystrophy, unspecified

14.

Sudeck

15.

Sudeck's Atrophy

16.

Sudeck's atrophy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	rofecoxib	FAERS: 4		OFFSIDES US FAERS
2	Isotretinoin	FAERS: 1		US FAERS
3	Mefloquine	FAERS: 1		US FAERS
4	Ofloxacin	FAERS: 1		US FAERS
5	Promethazine	FAERS: 1		US FAERS
6	Raloxifene Hydrochloride	FAERS: 1		US FAERS
7	Acebutolol			OFFSIDES
8	Bupivacaine		8484525	CTD
9	Bupropion			OFFSIDES
10	Calcitriol		18212635	CTD
11	Clonidine		15271746 16115995	CTD
12	Cocaine		11079580	CTD
13	Dicyclomine			SIDER
14	Epinephrine		8484525	CTD
15	Ergotamine		1922133	CTD
16	Ethionamide		5973275	CTD
17	Everolimus			SIDER
18	Gabapentin		10442276 11392062	CTD
19	Guanethidine		6666530	CTD
20	Isoniazid		5267560 5364187 5973275	CTD
21	Ketamine		20638877	CTD
22	Ketorolac			OFFSIDES
23	Ketorolac Tromethamine			OFFSIDES
24	Labetalol			OFFSIDES
25	Lidoderm		15271746 16115995	CTD
26	Mefloquine			OFFSIDES
27	Methadone		11783819	CTD
28	Minoxidil			OFFSIDES
29	Mupirocin			OFFSIDES
30	Nifedipine		18212635	CTD
31	Phenobarbital		View details 2464337 2578677 3003874 3146789 3671844 4136241 4162951 6857200 8156963 8962978 9471167 9608219 10442276 11392062 16986675 17722788	CTD
32	Prednisone		8156963 16986675	CTD
33	Secobarbital		8156963	CTD
34	Sirolimus		17575313 18212635	CTD
35	Sumatriptan			OFFSIDES
36	Tretinoin			OFFSIDES
37	naratriptan			OFFSIDES
38	parecoxib		16115995	CTD
39	temsirolimus			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Causalgia	52.9%
2	Brachial Plexus Neuritis	27.6%
3	Neuralgic Amyotrophy	27.6%
4	Neuritis	27.5%
5	Polyneuritis	27.5%
6	Radiculitis	27.5%
7	Polyneuropathy	27.5%
8	Mononeuritis	27.5%
9	Mononeuropathies	27.5%
10	Brachial Plexus Neuropathies	27.5%
11	Radiculopathy	27.5%
12	Mononeuropathy Multiplex	27.5%
13	Nerve Root Compression	27.5%
14	Motor Neuron Disease	27.4%
15	Dysautonomia	25.8%
16	Autonomic Dysreflexia	25.2%
17	Peripheral Nerve Injuries	24.5%
18	Guillain-Barre Syndrome	24.4%
19	Tarsal Tunnel Syndrome	24.3%
20	Cauda Equina Syndrome	24.3%
21	Neuromuscular Junction Diseases	23.6%
22	Cranial nerve diseases	22.4%
23	Demyelinating Diseases	22.4%
24	Demyelination	22.4%
25	Chronobiology Disorders	22.4%
26	Stiff-Person Syndrome	22%
27	Polyradiculoneuropathy	21.9%
28	Polyradiculoneuritis	21.9%
29	Multiple System Atrophy	21.1%
30	Isaacs syndrome	21%
31	Diabetic Neuropathies	20.7%
32	Diabetic Amyotrophy	20.7%
33	Diabetic Autonomic Neuropathy	20.7%
34	Neuralgia	20.5%
35	Neuropathic pain	20.5%
36	Acrodynia	19.5%
37	Carpal Tunnel Syndrome	19.5%
38	Sciatica	19.4%
39	Sweating, Gustatory	19.2%
40	Auriculotemporal Syndrome	19.2%
41	Myopathy	18.6%
42	Sciatic Neuropathy	18.5%
43	Ulnar Neuropathies	18.5%
44	Lesion of Sciatic Nerve	18.5%
45	Ulnar Neuritis	18.5%
46	Radial nerve compression	18.5%
47	Radial Tunnel Syndrome	18.5%
48	Peroneal Neuropathies	18.5%
49	Radial Neuropathy	18.5%
50	Median Neuropathy	18.5%
51	Sciatic Nerve Palsy	18.5%
52	Femoral Neuropathy	18.5%
53	Tibial Neuropathy	18.5%
54	Ulnar Nerve Palsy	18.5%
55	Radial nerve palsy	18.5%
56	Spinal Muscular Atrophy	17.9%
57	Progressive Muscular Atrophy	17.9%
58	Hand-Arm Vibration Syndrome	17.5%
59	Trauma, Nervous System	17.4%
60	Poliomyelitis	17%
61	Nervous System Neoplasms	16.8%
62	Neurologic Manifestations	16.8%
63	Neurotoxicity Syndromes	16.8%
64	Cubital Tunnel Syndrome	16.8%
65	Progressive bulbar palsy	16.5%
66	Bulbar palsy	16.5%
67	Chronic Fatigue Syndrome	16.4%
68	Miller Fisher Syndrome	16.3%
69	Myasthenia Gravis	16.1%
70	Amyotrophic Lateral Sclerosis	16%
71	Ocular Motility Disorders	15.6%
72	Cyclophoria	15.6%
73	Horner Syndrome	15.4%
74	Encephalomyelitis	15.1%
75	Prion Diseases	15.1%
76	Restless Legs Syndrome	15%
77	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	14.7%
78	Striatonigral Degeneration	14.6%
79	Thoracic Outlet Syndrome	14.2%
80	Polyradiculopathy	14.1%
81	Subacute Combined Degeneration	13.9%
82	Sleep Wake Disorders	13.7%
83	Botulism	13.3%
84	Marchiafava-Bignami Disease	13.3%
85	Parkinson Disease	13.2%
86	Meningoencephalitis	13.1%
87	Neuritis, Autoimmune, Experimental	13%
88	Ophthalmoplegic Migraine	13%
89	Lambert-Eaton Myasthenic Syndrome	12.9%
90	Shy-Drager Syndrome	12.6%
91	Spinal Cord Injuries	12.6%
92	Orthostatic intolerance	12.4%
93	Brain Diseases	12.4%
94	Meningitis	12.4%
95	Movement Disorders	12.4%
96	Pachymeningitis	12.4%
97	Spinal Cord Diseases	12.4%
98	Vagus Nerve Disorder	12.4%
99	Glossopharyngeal Neuralgia	12.4%
100	Abducens Nerve Diseases	12.4%
101	Heavy Metal Poisoning, Nervous System	12.4%
102	Tauopathies	12.4%
103	Trochlear Nerve Diseases	12.4%
104	Asterixis	12.1%
105	Ballismus	12.1%
106	Postural Orthostatic Tachycardia Syndrome	12%
107	Neuromuscular Diseases	11.8%
108	Lewy Body Disease	11.8%
109	neurofibroma	11.7%
110	Dandy-Walker Syndrome	11.6%
111	Charcot-Marie-Tooth Disease	11.6%
112	Myelitis	11.6%
113	Pneumocephalus	11.5%
114	Myositis	10.9%
115	Myotonic Disorders	10.9%
116	Myasthenic Syndromes, Congenital	10.9%
117	Neuroleptic Malignant Syndrome	10.7%
118	Myelinolysis, Central Pontine	10.7%
119	Progressive supranuclear palsy	10.5%
120	Sleep Disorders, Circadian Rhythm	10.4%
121	Epidural Abscess	10.4%
122	Olfactory Nerve Injuries	10.4%
123	Leukoencephalitis, Acute Hemorrhagic	10.2%
124	Myelitis, Transverse	10.2%
125	MPTP Poisoning	10.2%
126	Central Nervous System Cysts	10%
127	Subdural Effusion	9.8%
128	Parkinsonian Disorders	9.8%
129	Nocturnal Myoclonus Syndrome	9.8%
130	Encephalomyelitis, Acute Disseminated	9.8%
131	Central Nervous System Infection	9.7%
132	Optic Neuropathy	9.7%
133	Dyskinesia, Drug-Induced	9.6%
134	Opsoclonus-Myoclonus Syndrome	9.6%
135	Neuromyelitis Optica	9.5%
136	Facial Nerve Diseases	9.4%
137	Craniocerebral Trauma	9.4%
138	Parasomnia	9.4%
139	Dyssomnias	9.4%
140	Myasthenia Gravis, Autoimmune, Experimental	9.4%
141	Dystonia Musculorum Deformans	9.3%
142	POEMS Syndrome	9.3%
143	Brain Injuries	9.3%
144	Vestibulocochlear Nerve Diseases	9.2%
145	Decerebrate State	9.2%
146	Hemiparesis	9.2%
147	Hydranencephaly	9.2%
148	Meningism	9.2%
149	Neural Tube Defects	9.2%
150	Paresis	9.2%
151	Seizures	9.2%
152	Sensation Disorders	9.2%
153	Tethered Cord Syndrome	9.2%
154	Central Nervous System Neoplasms	9.2%
155	Complex partial seizures	9.2%
156	Iniencephaly	9.2%
157	Craniorachischisis	9.2%
158	Exencephaly	9.2%
159	Monoparesis	9.2%
160	Septo-Optic Dysplasia	9.2%
161	Cortical Dysplasia	9.2%
162	Neurogenic Inflammation	9.2%
163	Gait Disorders, Neurologic	9.2%
164	Neuromuscular Manifestations	9.2%
165	Malformations of Cortical Development	9.2%
166	Brain Neoplasms	9.2%
167	Multiple Sclerosis	9.2%
168	Spinal Cord Neoplasms	9.2%
169	Hypotension, Orthostatic	9%
170	Post-Exercise Hypotension	9%
171	Facial Nerve Injuries	8.9%
172	Fibromyalgia	8.8%
173	Medial Tibial Stress Syndrome	8.8%
174	Myotonia Congenita	8.8%
175	Mitochondrial Myopathies	8.7%
176	Eosinophilia-Myalgia Syndrome	8.7%
177	Amyloid Neuropathies, Familial	8.7%
178	Akathisia, Drug-Induced	8.6%
179	Myotonic Dystrophy	8.4%
180	Leukoencephalopathy, Progressive Multifocal	8.3%
181	Meige Syndrome	8.1%
182	Cerebral Ventriculitis	8.1%
183	Epilepsy, Post-Traumatic	8.1%
184	Scrapie	8%
185	Central Cord Syndrome	8%
186	Limbic Encephalitis	7.9%
187	Presenile dementia	7.9%
188	Senile dementia	7.9%
189	Meningitis, Bacterial	7.9%
190	Meningitis, Fungal	7.9%
191	Chorea	7.8%
192	Brain Abscess	7.8%
193	Ophthalmoplegia	7.8%
194	External Ophthalmoplegia	7.8%
195	Akinetic Mutism	7.7%
196	Anoxic Encephalopathy	7.7%
197	Arachnoiditis	7.7%
198	Basal Ganglia Diseases	7.7%
199	Brain Damage, Chronic	7.7%
200	Cerebellar Diseases	7.7%
201	Encephalitis	7.7%
202	Encephalomalacia	7.7%
203	Epilepsy	7.7%
204	Hydrocephalus	7.7%
205	Congenital Hydrocephalus	7.7%
206	Hypothalamic Diseases	7.7%
207	Aseptic Meningitis	7.7%
208	Pupil Disorders	7.7%
209	Syringomyelia	7.7%
210	Thalamic Diseases	7.7%
211	Intracranial Hypertension	7.7%
212	Aura	7.7%
213	Leukoencephalopathy	7.7%
214	Essential Tremor	7.7%
215	Neuroaxonal Dystrophies	7.7%
216	Familial Tremor	7.7%
217	Headache Disorders	7.7%
218	Intracranial Hypotension	7.7%
219	Neurobehavioral Manifestations	7.7%
220	Brain Edema	7.7%
221	Brain Hypoxia	7.7%
222	Aqueductal Stenosis	7.7%
223	Pneumorrhachis	7.7%
224	Writer's Cramp	7.7%
225	Huntington Disease	7.7%
226	Vasculitis, Central Nervous System	7.6%
227	Jet Lag Syndrome	7.6%
228	Complex Regional Pain Syndromes	7.6%
229	Paraneoplastic Encephalomyelitis	7.5%
230	Alstrom Syndrome	7.4%
231	Uveomeningoencephalitic Syndrome	7.4%
232	Polymyositis	7.4%
233	Sturge-Weber Syndrome	7.3%
234	Vertigo	7.3%
235	Alcohol-Induced Disorders, Nervous System	7.3%
236	Lafora Disease	7.3%
237	Unverricht-Lundborg Syndrome	7.3%
238	Posterior Leukoencephalopathy Syndrome	7.3%
239	Posterior reversible encephalopathy syndrome	7.3%
240	Lupus Vasculitis, Central Nervous System	7.2%
241	Refsum Disease	7.2%
242	Familial Periodic Paralysis	7.2%
243	Tuberous Sclerosis	7.1%
244	Canavan Disease	7%
245	Alexander Disease	7%
246	Cerebellar Neoplasms	7%
247	Brain Death	6.9%
248	Coma, Post-Head Injury	6.9%
249	Neurofibrosarcoma	6.8%
250	Peripheral Nervous System Diseases	6.7%
251	Vocal Cord Paralysis	6.7%
252	Ataxia Telangiectasia	6.7%
253	Dementia, Vascular	6.6%
254	Brain Hemorrhage, Traumatic	6.6%
255	Amblyopia	6.6%
256	Paraneoplastic Cerebellar Degeneration	6.6%
257	Mitochondrial Encephalomyopathies	6.5%
258	Creutzfeldt-Jakob disease	6.5%
259	Basal Ganglia Cerebrovascular Disease	6.5%
260	Cerebrospinal Fluid Otorrhea	6.5%
261	Cerebrospinal Fluid Rhinorrhea	6.5%
262	Gait Ataxia	6.5%
263	Friedreich Ataxia	6.5%
264	Brain Injuries, Diffuse	6.5%
265	Traumatic Brain Injury	6.5%
266	Cerebellar Ataxia	6.5%
267	Supratentorial Neoplasms	6.5%
268	Torticollis	6.5%
269	Multiple Sclerosis, Chronic Progressive	6.5%
270	Multiple Sclerosis, Relapsing-Remitting	6.5%
271	Myoclonic Epilepsy	6.5%
272	Epilepsy, Temporal Lobe	6.5%
273	Epilepsy, Rolandic	6.5%
274	Benign Rolandic Epilepsy	6.5%
275	Voice Disorders	6.3%
276	Voice Disturbance	6.3%
277	Smith-Magenis syndrome	6.1%
278	Myalgia	6.1%
279	Dural Arteriovenous Fistula	6.1%
280	Carotid Artery Injuries	6.1%
281	Muscular Dystrophy	6%
282	Orbital Myositis	6%
283	Tuberculosis, Meningeal	6%
284	Pyomyositis	5.9%
285	Brain Diseases, Metabolic	5.9%
286	Cerebrovascular Disorders	5.9%
287	Optic Atrophy	5.9%
288	Optic Neuritis	5.9%
289	Papilledema	5.9%
290	Strabismus	5.9%
291	Tolosa-Hunt Syndrome	5.9%
292	Cerebrovascular Insufficiency	5.9%
293	Arsenic Poisoning	5.9%
294	Dementia	5.9%
295	Central Nervous System Fungal Infections	5.9%
296	Conus Medullaris Syndrome	5.9%
297	Spinal Cord Vascular Diseases	5.9%
298	Vascular Headaches	5.9%
299	Hypoxia-Ischemia, Brain	5.8%
300	Tardive Dyskinesia	5.8%
301	Hepatolenticular Degeneration	5.8%
302	Persistent Vegetative State	5.8%
303	Facial Injuries	5.8%
304	Facial Neuralgia	5.8%
305	Sleep Talking	5.8%
306	Manganese Poisoning	5.8%
307	Sleep Disorders, Intrinsic	5.8%
308	Anosmia	5.7%
309	Ataxia	5.7%
310	Athetosis	5.7%
311	Catalepsy	5.7%
312	Dystonia	5.7%
313	Hemiplegia	5.7%
314	Locked-In Syndrome	5.7%
315	Meningeal Neoplasms	5.7%
316	Meningomyelocele	5.7%
317	Muscle Hypertonia	5.7%
318	Muscle hypotonia	5.7%
319	Myoclonus	5.7%
320	Myotonia	5.7%
321	Paraplegia	5.7%
322	Pseudobulbar Palsy	5.7%
323	Quadriplegia	5.7%
324	Spasm	5.7%
325	Spastic Paraplegia	5.7%
326	Status Epilepticus	5.7%
327	Taste Disorders	5.7%
328	Tremor	5.7%
329	Spina Bifida	5.7%
330	Monoplegia	5.7%
331	Hypokinesia	5.7%
332	Paraparesis	5.7%
333	Bradykinesia	5.7%
334	Waxy flexibility	5.7%
335	Action Tremor	5.7%
336	Resting Tremor	5.7%
337	Dysosmia	5.7%
338	Quadriparesis	5.7%
339	Mercury Poisoning, Nervous System	5.7%
340	Olfaction Disorders	5.7%
341	Myokymia	5.7%
342	Lead Poisoning, Nervous System	5.7%
343	Vestibular Neuronitis	5.7%
344	Somatosensory Disorders	5.7%
345	Hyperkinesia	5.7%
346	Intention tremor	5.7%
347	Alcohol Withdrawal Seizures	5.7%
348	Juvenile Myoclonic Epilepsy	5.6%
349	Myoclonic Epilepsies, Progressive	5.6%
350	Akathisia	5.6%
351	Restlessness	5.6%
352	Psychomotor Agitation	5.6%
353	Leukomalacia, Periventricular	5.5%
354	Alice in Wonderland Syndrome	5.4%
355	Cerebral Palsy	5.4%
356	Epilepsies, Partial	5.4%
357	Epilepsy, Generalized	5.4%
358	Pseudotumor Cerebri	5.4%
359	Hypertensive Encephalopathy	5.4%
360	Simple Partial Seizures	5.4%
361	Epilepsy, Reflex	5.4%
362	Headache Disorders, Primary	5.4%
363	Headache Disorders, Secondary	5.4%
364	Medication overuse headache	5.4%
365	Brain Concussion	5.3%
366	Reflex, Abnormal	5.2%
367	Hyporeflexia	5.2%
368	Hyperreflexia	5.2%
369	Diffuse Axonal Injury	5.1%
370	Brain Stem Neoplasms	5.1%
371	Vertebral Artery Dissection	5.1%
372	Amnesia, Transient Global	5.1%
373	Gait Apraxia	5.1%
374	Optic Nerve Glioma	5.1%
375	Toxoplasmosis, Cerebral	5.1%
376	Reflex Sympathetic Dystrophy	4.9%
377	Pituitary Adenoma	4.9%
378	Pituitary Neoplasms	4.9%
379	Meningitis, Cryptococcal	4.9%
380	Hypokalemic periodic paralysis	4.9%
381	Meningitis, Listeria	4.9%
382	Meningitis, Haemophilus	4.8%
383	Meningitis, Pneumococcal	4.8%
384	Frontotemporal dementia	4.8%
385	Vision Disorders	4.8%
386	Metamorphopsia	4.8%
387	Visual Impairment	4.8%
388	Optic Neuropathy, Ischemic	4.8%
389	Anterior Ischemic Optic Neuropathy	4.8%
390	Central Nervous System Bacterial Infections	4.8%
391	Facial Hemiatrophy	4.7%
392	Melkersson-Rosenthal Syndrome	4.7%
393	Anisocoria	4.7%
394	Confusion	4.7%
395	Facial paralysis	4.7%
396	Lethargy	4.7%
397	Memory Disorders	4.7%
398	Muscle Cramp	4.7%
399	Perceptual Disorders	4.7%
400	Psychomotor Disorders	4.7%
401	Tonic Pupil	4.7%
402	Anhedonia	4.7%
403	Disorientation	4.7%
404	Facial Paresis	4.7%
405	Memory Loss	4.7%
406	Hemisensory Neglect	4.7%
407	Dysacusis	4.7%
408	Sleep Bruxism	4.6%
409	Anencephaly	4.6%
410	Meningocele	4.6%
411	Muscular Atrophy	4.6%
412	Respiratory Paralysis	4.6%
413	Encephalocele	4.6%
414	Basal Ganglia Hemorrhage	4.6%
415	Tetany	4.6%
416	Welander Distal Myopathy	4.6%
417	Choroid Plexus Papilloma	4.5%
418	MELAS Syndrome	4.4%
419	Pituitary Apoplexy	4.4%
420	Post-Traumatic Headache	4.3%
421	Tension Headache	4.3%
422	Epilepsy, Complex Partial	4.3%
423	Migraine Disorders	4.3%
424	Abdominal Migraine	4.3%
425	Status Migrainosus	4.3%
426	Cervicogenic Headache	4.3%
427	Brain Contusion	4.3%
428	Pituitary Diseases	4.3%
429	Brain Infarction	4.3%
430	Subarachnoid Hemorrhage, Traumatic	4.3%
431	Carotid Artery, Internal, Dissection	4.3%
432	Subacute Sclerosing Panencephalitis	4.2%
433	Acoustic Neuroma	4.1%
434	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
435	Carotid Artery Diseases	4.1%
436	Brain Ischemia	4.1%
437	Esotropia	4.1%
438	Exotropia	4.1%
439	Sleep Apnea Syndromes	4.1%
440	Cerebrovascular accident	4.1%
441	Kluver-Bucy Syndrome	4.1%
442	Vasospasm, Intracranial	4.1%
443	Spinal Cord Ischemia	4.1%
444	Intracranial Arterial Diseases	4.1%
445	Putaminal Hemorrhage	4.1%
446	Auditory Perceptual Disorders	4.1%
447	Disorders of Excessive Somnolence	4.1%
448	Sleep Initiation and Maintenance Disorders	4.1%
449	Night Terrors	4.1%
450	Somnambulism	4.1%
451	Trigeminal Nerve Disorder	4.1%
452	Transient Insomnia	4.1%
453	Sleep Paralysis	4.1%
454	Chronic Insomnia	4.1%
455	REM Sleep Behavior Disorder	4.1%
456	Hypersomnia	4.1%
457	Dermal Sinus	4%
458	Dysgeusia	4%
459	Formication	4%
460	Hyperalgesia	4%
461	Hyperesthesia	4%
462	Hypesthesia	4%
463	Language Disorders	4%
464	Numbness	4%
465	Paresthesia	4%
466	Paraparesis, Spastic	4%
467	Spina Bifida Cystica	4%
468	Trismus	4%
469	Spina Bifida Occulta	4%
470	Epilepsia Partialis Continua	4%
471	Hypogeusia	4%
472	Meningeal Carcinomatosis	4%
473	Brown-Sequard Syndrome	4%
474	Lissencephaly	4%
475	Polymicrogyria	4%
476	Pachygyria	4%
477	Schizencephaly	4%
478	Lockjaw	4%
479	Allodynia	4%
480	Lead Poisoning, Nervous System, Childhood	4%
481	Lead Poisoning, Nervous System, Adult	4%
482	Periventricular Nodular Heterotopia	4%
483	Ageusia	4%
484	Tuberculosis, Central Nervous System	4%
485	Kearns-Sayre syndrome	4%
486	Adrenoleukodystrophy	4%
487	Giant Cell Arteritis	4%
488	Temporal Arteritis	4%
489	Infarction, Middle Cerebral Artery	4%
490	Infarction, Anterior Cerebral Artery	4%
491	Infarction, Posterior Cerebral Artery	4%
492	Duane Retraction Syndrome	4%
493	Consciousness Disorders	3.9%
494	Mental Retardation	3.9%
495	Muscle Weakness	3.9%
496	Depressed Level of Consciousness	3.9%
497	Mental deficiency	3.9%
498	Intellectual Disability	3.9%
499	Mobius Syndrome	3.9%
500	Bell Palsy	3.9%
501	Dermatomyositis	3.9%
502	Catatonia	3.9%
503	Herpes Zoster Oticus	3.9%
504	Aphonia	3.8%
505	Sleep Deprivation	3.8%
506	Dysphonia	3.8%
507	Muscular Dystrophy, Duchenne	3.8%
508	Cluster Headache	3.8%
509	Migraine with Aura	3.8%
510	Familial Hemiplegic Migraine	3.8%
511	Chronic Paroxysmal Hemicrania	3.8%
512	SUNCT Syndrome	3.8%
513	Paroxysmal Hemicrania	3.8%
514	Cerebral Infarction	3.7%
515	Brain Stem Infarctions	3.7%
516	Alexia	3.7%
517	Dyslexia	3.7%
518	Moyamoya Disease	3.5%
519	Lateral Medullary Syndrome	3.5%
520	Hematoma, Subdural	3.4%
521	Hematoma, Epidural, Cranial	3.4%
522	Eye Injuries	3.4%
523	Congenital nystagmus	3.3%
524	West Nile Fever	3.3%
525	Empty Sella Syndrome	3.3%
526	Hyperpituitarism	3.3%
527	Hypopituitarism	3.3%
528	Hypophysitis	3.3%
529	Diplopia	3.3%
530	Muscle Rigidity	3.3%
531	Muscle Spasticity	3.3%
532	Scotoma	3.3%
533	Photophobia	3.3%
534	Cogwheel Rigidity	3.3%
535	Hemifacial Spasm	3.3%
536	Amaurosis	3.3%
537	Blindness	3.3%
538	Nuchal Rigidity	3.3%
539	Reye Syndrome	3.3%
540	Neuroaspergillosis	3.3%
541	Intracranial Embolism and Thrombosis	3.3%
542	Hepatic Encephalopathy	3.3%
543	Agnosia	3.3%
544	Apraxias	3.3%
545	Hallucinations	3.3%
546	Hemianopsia	3.3%
547	Hyperacusis	3.3%
548	Tinnitus	3.3%
549	Visual Agnosia	3.3%
550	Anosognosia	3.3%
551	Wernicke-Korsakoff Syndrome	3.3%
552	Phonophobia	3.3%
553	Hearing Loss	3.3%
554	Neuronal Ceroid-Lipofuscinoses	3.3%
555	Optic Atrophy, Hereditary, Leber	3.3%
556	Cerebral Arterial Diseases	3.2%
557	Vertebrobasilar Insufficiency	3.2%
558	Anterior Spinal Artery Syndrome	3.2%
559	Basilar Artery Stenosis	3.2%
560	Vertebral Artery Stenosis	3.2%
561	Sleep Apnea, Obstructive	3.2%
562	Sleep Apnea, Central	3.2%
563	Intracranial Hemorrhage, Hypertensive	3.2%
564	Transient Cerebral Ischemia	3.2%
565	Sarcopenia	3.2%
566	Narcolepsy	3.2%
567	Trigeminal Neuralgia	3.2%
568	Kleine-Levin Syndrome	3.2%
569	Agraphia	3.2%
570	Anomia	3.2%
571	Cluttering	3.2%
572	Language Development Disorders	3.2%
573	Speech Disorders	3.2%
574	Syncope	3.2%
575	Stupor	3.2%
576	Dysgraphia	3.2%
577	Presyncope	3.2%
578	Dyslalia	3.2%
579	Aicardi's syndrome	2.9%
580	Hoarseness	2.9%
581	Hematoma, Subdural, Intracranial	2.9%
582	Hematoma, Subdural, Chronic	2.9%
583	Hematoma, Subdural, Acute	2.9%
584	Cockayne Syndrome	2.9%
585	Alcohol Withdrawal Delirium	2.9%
586	Pseudorabies	2.9%
587	Hyperprolactinemia	2.9%
588	Subclavian Steal Syndrome	2.8%
589	Pick Disease of the Brain	2.8%
590	Cataplexy	2.8%
591	Aphasia	2.8%
592	Articulation Disorders	2.8%
593	Echolalia	2.8%
594	Stuttering	2.8%
595	Dysphasia	2.8%
596	Amnesia	2.8%
597	Delirium	2.8%
598	Dissociative Amnesia	2.8%
599	Color blindness	2.8%
600	Global Amnesia	2.8%
601	Cri-du-Chat Syndrome	2.7%
602	Down Syndrome	2.7%
603	Brain Diseases, Metabolic, Inborn	2.7%
604	Trisomy 21	2.7%
605	Meningioma	2.7%
606	Williams Syndrome	2.7%
607	Microcephaly	2.7%
608	Macrocephaly	2.7%
609	Neurosyphilis	2.7%
610	Porencephaly	2.7%
611	Toxoplasmosis, Congenital	2.6%
612	Eye Burns	2.6%
613	Malaria, Cerebral	2.6%
614	Carotid Stenosis	2.6%
615	Intracranial Aneurysm	2.6%
616	Dysarthria	2.6%
617	Neurocysticercosis	2.6%
618	Amaurosis Fugax	2.6%
619	Blindness, Cortical	2.6%
620	Dyscalculia	2.6%
621	Intracranial Arteriosclerosis	2.6%
622	Cerebral Atherosclerosis	2.6%
623	Rett Syndrome	2.6%
624	Subarachnoid Hemorrhage	2.6%
625	Cerebral Arteriosclerosis	2.6%
626	Cerebral Hemorrhage	2.6%
627	Cerebral Thrombosis	2.6%
628	Intracranial Embolism	2.6%
629	Intracranial Thrombosis	2.6%
630	Deafness	2.6%
631	Hearing Loss, Sudden	2.6%
632	Gerstmann Syndrome	2.6%
633	Hearing Loss, Bilateral	2.6%
634	Hearing Loss, High-Frequency	2.6%
635	Hearing Loss, Mixed Conductive-Sensorineural	2.6%
636	Prosopagnosia	2.6%
637	Apraxia, Ideomotor	2.6%
638	Charles Bonnet Syndrome	2.6%
639	Hearing Loss, Unilateral	2.6%
640	Complete Hearing Loss	2.6%
641	Alien Hand Syndrome	2.6%
642	Deaf Mutism	2.6%
643	Holoprosencephaly	2.6%
644	Prader-Willi Syndrome	2.3%
645	Wernicke Encephalopathy	2.3%
646	AIDS Dementia Complex	2.3%
647	Phantom pain	2.3%
648	Phantom Limb Pain	2.3%
649	Lyme Neuroborreliosis	2.3%
650	Mutism	2.3%
651	Selective Mutism	2.3%
652	Acromegaly	2.3%
653	Cerebral Amyloid Angiopathy	2.3%
654	Sinus Thrombosis, Intracranial	2.2%
655	Corneal Scar	2.2%
656	Waterhouse-Friderichsen Syndrome	2.2%
657	Retrograde amnesia	2.2%
658	Amnesia, Anterograde	2.2%
659	Menkes Kinky Hair Syndrome	2.2%
660	Carotid Artery Thrombosis	2.2%
661	Alexia, Pure	2.1%
662	Kernicterus	2.1%
663	Cavernous Sinus Thrombosis	2.1%
664	Sagittal Sinus Thrombosis	2.1%
665	Corneal Perforation	1.9%
666	Fragile X Syndrome	1.8%
667	Rubinstein-Taybi Syndrome	1.8%
668	Nelson Syndrome	1.7%
669	Fabry Disease	1.7%
670	Prolactinoma	1.6%
671	Growth Hormone-Secreting Pituitary Adenoma	1.6%
672	Galactosemias	1.6%
673	Urea Cycle Disorders, Inborn	1.6%
674	Tyrosinemias	1.6%
675	Homocystinuria	1.4%
676	Leigh Disease	1.4%
677	Mucopolysaccharidosis II	1.3%
678	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
679	Glycogen storage disease type II	1.1%
680	Zellweger Syndrome	1.1%
681	Gaucher Disease	0.9%
682	Tay-Sachs Disease	0.9%
683	Niemann-Pick Disease, Type C	0.8%

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