MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acidosis, Lactic

(UMLS:C0001125)

Definition:: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
UMLS ID:: C0001125
MeSH ID:: D000140

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.076.176.180

Synonym(s)

Acidosis, Lactic

ACIDOSIS LACTIC

LACTIC ACIDOSIS

Lactic Acidosis

Lactic acidosis

Lacticacidosis

acidosis lactic

lactacidosis

lactic acidosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetaminophen	10447915 18609519	CTD
2	Alcohols	404836 2054009	CTD
3	Clozapine	9034416	CTD
4	Creatine	20223410	CTD
5	Didanosine	View details 8151270 11356442 11450788 15040545 16176639 23782481	CTD
6	Disulfiram	19702547	CTD
7	Epinephrine	10925653 21037469	CTD
8	Fluorouracil	9020500 9635854	CTD
9	Glucose	19427052	CTD
10	Glyburide	1602014	CTD
11	Hydron;carbonate	11910877 19427052 20578420	CTD
12	Indinavir	16798620	CTD
13	Lactic Acid	11356440	CTD
14	Lamivudine	10894300 17279048 18580619	CTD
15	Metformin	View details 3865878 4217736 8955764 8997466 10643227 10742816 11045136 11471623 11910877 14604317 14633764 16190374 16620273 17259530 17520852 18251038 18259965 18431417 19427052 20223410 20578420 20627210	CTD
16	Methylprednisolone	2721092 10925653	CTD
17	Mustard Gas	25331496	CTD
18	Nevirapine	17279048	CTD
19	Niacin	2054009	CTD
20	Nifedipine	19702547	CTD
21	Phenformin	View details 404836 1140086 3865878 4216957 4701475 4985361 5056303 23221006	CTD
22	Prednisone	3703509	CTD
23	Procainamide	3155037	CTD
24	Propofol	9875925 19295389	CTD
25	Propylene Glycol	19920159	CTD
26	Ribavirin	11214134 15040545	CTD
27	Ritonavir	9786823	CTD
28	S-methylisothiopseudouronium	9445295	CTD
29	Sodium Acetate	4217736	CTD
30	Stavudine	View details 10894300 10906833 11356442 15547198 17279048 18580619 19702629 19732926 23782481	CTD
31	Tenofovir	16176639	CTD
32	Valproic Acid	3922731	CTD
33	Vancomycin	11356440	CTD
34	Zidovudine	View details 9267960 9587562 10219365 23782481	CTD
35	chloroacetic acid	15720133	CTD
36	efavirenz	17279048	CTD
37	methyl isocyanate	8440870	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Ketosis	48.4%
2	Ketonuria	48.4%
3	Ketoacidosis	48.4%
4	Ketonemia	48.4%
5	Alkalosis	34.4%
6	Acidosis, Respiratory	32.6%
7	Calcium Metabolism Disorders	25.4%
8	Iron Metabolism Disorders	25.4%
9	Phosphorus Metabolism Disorders	25.4%
10	Water-Electrolyte Imbalance	25.4%
11	Lipid Metabolism Disorders	25.4%
12	Mitochondrial Diseases	25.4%
13	Glucose Metabolism Disorders	25.4%
14	Achlorhydria	23.1%
15	Diabetic Ketoacidosis	23.1%
16	Wasting Syndrome	23%
17	Hypercalcemia	19.8%
18	Hypocalcemia	19.8%
19	Milk-Alkali Syndrome	19.8%
20	Renal tubular acidosis	19.3%
21	Osteopenia	17.2%
22	Brain Diseases, Metabolic	16.9%
23	Nutrition Disorders	16.4%
24	Alkalosis, Respiratory	15.2%
25	Lipodystrophy	14.9%
26	Amyloidosis	14.8%
27	Calcinosis	14.8%
28	Hyperglycemia	14.8%
29	Hyperinsulinism	14.8%
30	Hyperkalemia	14.8%
31	Hypernatremia	14.8%
32	Hypoglycemia	14.8%
33	Hypokalemia	14.8%
34	Hyponatremia	14.8%
35	Xanthomatosis	14.8%
36	Hypophosphatemia	14.8%
37	Dyslipidemias	14.8%
38	Iron Overload	14.8%
39	Xanthoma	14.8%
40	Pseudohypoparathyroidism	13.1%
41	Rickets	12.6%
42	Brain Diseases, Metabolic, Inborn	11.8%
43	Diabetes Mellitus	10.6%
44	Hyperhomocysteinemia	10.5%
45	Leigh Disease	10.3%
46	Dehydration	10.1%
47	Lipomatosis	10.1%
48	Water Intoxication	10.1%
49	Werner Syndrome	10.1%
50	Amino Acid Metabolism, Inborn Errors	9.9%
51	Bloom Syndrome	9.9%
52	Carbohydrate Metabolism, Inborn Errors	9.9%
53	Metal Metabolism, Inborn Errors	9.9%
54	Osteoporosis	9.9%
55	Progeria	9.9%
56	Lysosomal Storage Diseases	9.9%
57	Bone Demineralization, Pathologic	9.9%
58	Cytochrome-c Oxidase Deficiency	9.9%
59	Peroxisomal Disorders	9.9%
60	Post-Traumatic Osteoporosis	9.9%
61	Celiac Disease	9.8%
62	Sprue, Tropical	9.8%
63	Steatorrhea	9.8%
64	Sprue	9.8%
65	Lactose Intolerance	9.7%
66	Calciphylaxis	9.7%
67	Hemosiderosis	9.7%
68	Hypolipoproteinemias	9.7%
69	Vascular calcification	9.7%
70	Carbamoyl-Phosphate Synthase I Deficiency Disease	9%
71	Hyperlipoproteinemia Type IV	8.6%
72	Hyperlipoproteinemia Type V	8.6%
73	Child Nutrition Disorders	8.5%
74	Hypervitaminosis A	8.5%
75	Infant Nutrition Disorders	8.5%
76	Malnutrition	8.5%
77	Hyperlipidemia, Familial Combined	8.4%
78	Osteomalacia	8.4%
79	Smith-Lemli-Opitz Syndrome	8.3%
80	Galactosemias	8.3%
81	Urea Cycle Disorders, Inborn	8.3%
82	Tyrosinemias	8.3%
83	Mitochondrial Encephalomyopathies	8.2%
84	Congenital Hyperinsulinism	8.1%
85	Hyperlipoproteinemia Type III	7.8%
86	Mitochondrial Myopathies	7.6%
87	Myelinolysis, Central Pontine	7.5%
88	Glycosuria	7.4%
89	Reye Syndrome	7.4%
90	Hepatic Encephalopathy	7.3%
91	Hyperphosphaturia	7.2%
92	Hypercholesterolemia	7.2%
93	Hyperlipoproteinemias	7.2%
94	Hypertriglyceridemia	7.2%
95	Hypoalphalipoproteinemias	7.2%
96	Familial Hypophosphatemic Rickets	6.8%
97	Homocystinuria	6.7%
98	HIV Wasting Syndrome	6.5%
99	Adiposis Dolorosa	6.5%
100	Alkaptonuria	6.5%
101	Glycogen Storage Disease	6.5%
102	Hypophosphatasia	6.5%
103	Insulin Resistance	6.5%
104	Osteoporosis, Postmenopausal	6.5%
105	Propionic acidemia	6.5%
106	Dihydropyrimidine Dehydrogenase Deficiency	6.5%
107	Cystinosis	6.5%
108	Glycogen storage disease type II	6.4%
109	Gaucher Disease	6.2%
110	Amyloid Neuropathies, Familial	6.1%
111	Porphyrias, Hepatic	6%
112	Necrobiosis Lipoidica Diabeticorum	5.9%
113	Fanconi Anemia	5.8%
114	Nesidioblastosis	5.8%
115	Neuronal Ceroid-Lipofuscinoses	5.7%
116	HIV-Associated Lipodystrophy Syndrome	5.5%
117	Wernicke Encephalopathy	5.5%
118	Zellweger Syndrome	5.3%
119	Renal Osteodystrophy	5.3%
120	Renal rickets	5.3%
121	MELAS Syndrome	5.3%
122	Menkes Kinky Hair Syndrome	5.3%
123	Adrenoleukodystrophy	5.1%
124	Gestational Diabetes	5.1%
125	Latent Autoimmune Diabetes in Adults	5.1%
126	Tay-Sachs Disease	5.1%
127	Diabetes Mellitus, Experimental	5%
128	Niemann-Pick Disease, Type C	4.9%
129	Deficiency Diseases	4.9%
130	Starvation	4.9%
131	Refeeding Syndrome	4.9%
132	Hepatolenticular Degeneration	4.9%
133	Nephrocalcinosis	4.9%
134	Tetany	4.9%
135	Friedreich Ataxia	4.9%
136	Refsum Disease	4.8%
137	Glycosuria, Renal	4.8%
138	Cerebral Amyloid Angiopathy	4.8%
139	Glycogen Storage Disease Type I	4.8%
140	Glycogen Storage Disease Type V	4.8%
141	Mucopolysaccharidosis III	4.8%
142	Fabry Disease	4.8%
143	Kernicterus	4.3%
144	Cockayne Syndrome	4.2%
145	Familial Periodic Paralysis	4%
146	Primary amyloidosis	3.9%
147	Kearns-Sayre syndrome	3.9%
148	Variegate Porphyria	3.9%
149	Acute intermittent porphyria	3.9%
150	Porphyria Cutanea Tarda	3.9%
151	Renal Aminoacidurias	3.9%
152	Fanconi Syndrome	3.9%
153	Pseudohypoaldosteronism	3.9%
154	Liddle Syndrome	3.9%
155	Ataxia Telangiectasia	3.8%
156	Optic Atrophy, Hereditary, Leber	3.7%
157	Sjogren-Larsson Syndrome	3.4%
158	Xeroderma Pigmentosum	3.3%
159	Gout	3.3%
160	Amyotrophic Lateral Sclerosis	3.3%
161	Antley-Bixler Syndrome Phenotype	3.2%
162	Canavan Disease	3.2%
163	Alexander Disease	3.2%
164	Kwashiorkor	3.2%
165	Magnesium Deficiency	3.2%
166	Potassium Deficiency	3.2%
167	Protein Deficiency	3.2%
168	Avitaminosis	3.2%
169	Mucopolysaccharidosis II	3.2%
170	Hypokalemic periodic paralysis	2.9%
171	Frontotemporal dementia	2.9%
172	Cystinuria	2.9%
173	CREST Syndrome	2.8%
174	Albinism	2.5%
175	Arthritis, Gouty	2.4%
176	Ascorbic Acid Deficiency	2.4%
177	Vitamin A Deficiency	2.4%
178	Vitamin D Deficiency	2.4%
179	Vitamin E Deficiency	2.4%
180	Marasmus	2.4%
181	Folic Acid Deficiency	2%
182	Pellagra	2%
183	Thiamine Deficiency	2%
184	Vitamin B 12 Deficiency	2%
185	Vitamin B 6 Deficiency	2%
186	Pyridoxine Deficiency	2%
187	Ichthyosis, X-Linked	2%
188	Obesity	1.9%
189	Beriberi	1.8%
190	Obesity, Abdominal	1.6%
191	Pediatric Obesity	1.3%
192	Vitamin K Deficiency	1.2%
193	Anemia, Pernicious	1.2%
194	Prader-Willi Syndrome	1.1%
195	Scurvy	1%
196	Subacute Combined Degeneration	0.6%

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