MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Classical Lissencephalies and Subcortical Band Heterotopias

(UMLS:C1955870)

Definition:: Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
UMLS ID:: C1955870
MeSH ID:: D054221

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.507.450.230|C10.500.507.450.499.230

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.507.450.230|C16.131.666.507.450.499.230|C16.320.322.500.186

Synonym(s)

Classical Lissencephalies and Subcortical Band Heterotopias

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Propylthiouracil		27216871	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Periventricular Nodular Heterotopia	49.4%
2	Aicardi's syndrome	32.5%
3	Classical Lissencephalies and Subcortical Band Heterotopias	30.9%
4	Hydranencephaly	30.2%
5	Neural Tube Defects	30.2%
6	Tethered Cord Syndrome	30.2%
7	Iniencephaly	30.2%
8	Craniorachischisis	30.2%
9	Exencephaly	30.2%
10	Septo-Optic Dysplasia	30.2%
11	Lissencephaly	28.5%
12	Pachygyria	28.5%
13	Dural Arteriovenous Fistula	27.2%
14	Holoprosencephaly	26.1%
15	Dandy-Walker Syndrome	25.9%
16	Central Nervous System Cysts	25.5%
17	Polymicrogyria	23.8%
18	Schizencephaly	23.8%
19	Tuberous Sclerosis	22.5%
20	Microcephaly	22.3%
21	Macrocephaly	22.3%
22	Anencephaly	22.2%
23	Smith-Magenis syndrome	21%
24	Porencephaly	20.9%
25	Fragile X Syndrome	20.2%
26	Alstrom Syndrome	19.7%
27	Beckwith-Wiedemann Syndrome	19.6%
28	Wolf-Hirschhorn Syndrome	19.6%
29	Cri-du-Chat Syndrome	18.6%
30	Down Syndrome	18.6%
31	Trisomy 21	18.6%
32	Rett Syndrome	17.6%
33	Meningomyelocele	17.3%
34	Spina Bifida	17.3%
35	Abnormalities, Drug-Induced	16.9%
36	Situs Inversus	16.9%
37	Charcot-Marie-Tooth Disease	16.9%
38	Rubinstein-Taybi Syndrome	16.8%
39	Prader-Willi Syndrome	16.8%
40	CHARGE Syndrome	16.8%
41	Ectodermal Dysplasia	15.7%
42	Aplasia Cutis Congenita	15.7%
43	Ichthyosis, X-Linked	15.3%
44	Meningocele	15.2%
45	Encephalocele	15.2%
46	Muscular Dystrophy, Duchenne	15%
47	Nail-Patella Syndrome	15%
48	Eye Abnormalities	15%
49	Cardiovascular Abnormalities	15%
50	Cockayne Syndrome	14.9%
51	Skin Abnormalities	14.7%
52	Lymphatic Abnormalities	14.7%
53	Congenital Microtia	14.7%
54	Refsum Disease	14.6%
55	Congenital diaphragmatic hernia	14.5%
56	Kartagener Syndrome	14.3%
57	Marfan Syndrome	14.1%
58	Cystic Fibrosis	14%
59	Mucopolysaccharidosis II	13.9%
60	Menkes Kinky Hair Syndrome	13.7%
61	Myasthenic Syndromes, Congenital	13.6%
62	Mobius Syndrome	13.3%
63	Urogenital Abnormalities	13.2%
64	Williams Syndrome	12.4%
65	Fetal Diseases	12.3%
66	Adrenoleukodystrophy	12.3%
67	Wiskott-Aldrich Syndrome	11.6%
68	Neoplastic Syndromes, Hereditary	11.4%
69	Xeroderma	11.3%
70	Polycystic Kidney Diseases	11.1%
71	Muscular Dystrophy	11.1%
72	Dermal Sinus	11.1%
73	Spina Bifida Cystica	11.1%
74	Spina Bifida Occulta	11.1%
75	Multiple Epiphyseal Dysplasia	11.1%
76	Osteochondrodysplasias	11.1%
77	Pelger-Huet Anomaly	11.1%
78	Werner Syndrome	11.1%
79	Myotonic Dystrophy	10.5%
80	Chronic granulomatous disease	10.4%
81	Retinal Dysplasia	10.3%
82	Aniridia	10.2%
83	Ataxia Telangiectasia	10.2%
84	Abnormalities, Radiation-Induced	10.2%
85	Smith-Lemli-Opitz Syndrome	10.2%
86	Epidermolysis Bullosa	10.1%
87	Maxillofacial Abnormalities	10%
88	Dwarfism	9.9%
89	Dextrocardia	9.9%
90	Anemia, Sickle Cell	9.9%
91	Thalassemia	9.9%
92	Albinism	9.9%
93	Hepatolenticular Degeneration	9.8%
94	Cranial nerve diseases	9.7%
95	Demyelinating Diseases	9.7%
96	Demyelination	9.7%
97	Neuromuscular Diseases	9.7%
98	Chronobiology Disorders	9.7%
99	Osteogenesis Imperfecta	9.7%
100	Dystonia Musculorum Deformans	9.4%
101	Genetic Diseases, Inborn	9.3%
102	Prune Belly Syndrome	9.2%
103	Twins, Conjoined	9.2%
104	Waardenburg Syndrome	9.2%
105	Meconium Aspiration Syndrome	9.1%
106	Primary Ciliary Dyskinesia	9%
107	Stiff-Person Syndrome	9%
108	Kallmann Syndrome	9%
109	Motor Neuron Disease	8.9%
110	Canavan Disease	8.8%
111	Alexander Disease	8.8%
112	Sjogren-Larsson Syndrome	8.8%
113	Restless Legs Syndrome	8.8%
114	Autoimmune Lymphoproliferative Syndrome	8.7%
115	Multiple System Atrophy	8.7%
116	Angioedemas, Hereditary	8.6%
117	Trauma, Nervous System	8.5%
118	Pseudoxanthoma Elasticum	8.5%
119	Amyloid Neuropathies, Familial	8.5%
120	Fabry Disease	8.4%
121	Nervous System Neoplasms	8.4%
122	Neurologic Manifestations	8.4%
123	Neurotoxicity Syndromes	8.4%
124	Scimitar Syndrome	8.3%
125	Polyradiculoneuropathy	8.2%
126	Polyradiculoneuritis	8.2%
127	Neuronal Ceroid-Lipofuscinoses	8.2%
128	Myotonia Congenita	8.2%
129	Lafora Disease	8.1%
130	Unverricht-Lundborg Syndrome	8.1%
131	Zellweger Syndrome	8.1%
132	Subacute Combined Degeneration	8%
133	Anophthalmos	8%
134	Anus, Imperforate	8%
135	Microphthalmos	8%
136	Limb Deformities, Congenital	8%
137	Craniofacial Abnormalities	8%
138	Anorectal Malformations	8%
139	Ocular Motility Disorders	8%
140	Cyclophoria	8%
141	Bloom Syndrome	8%
142	Xeroderma Pigmentosum	7.9%
143	Huntington Disease	7.8%
144	Ophthalmoplegic Migraine	7.6%
145	Sleep Wake Disorders	7.5%
146	POEMS Syndrome	7.4%
147	Abdominal Cramps	7.4%
148	Amniotic Band Syndrome	7.4%
149	Asphyxia Neonatorum	7.4%
150	Infant, Premature, Diseases	7.4%
151	Infantile Colic	7.4%
152	Familial Mediterranean Fever	7.4%
153	Basal Cell Nevus Syndrome	7.2%
154	Amyotrophic Lateral Sclerosis	7.1%
155	Blepharophimosis	7.1%
156	Laryngostenosis	7.1%
157	Mouth Abnormalities	7.1%
158	Duane Retraction Syndrome	7.1%
159	Esophageal Atresia	7%
160	Intestinal Atresia	7%
161	Horseshoe Kidney	7%
162	Pectus excavatum	7%
163	Klippel-Feil Syndrome	7%
164	Gastroschisis	7%
165	Synostosis	7%
166	Congenital nystagmus	7%
167	Acrodermatitis	7%
168	Lymphangiectasis, Intestinal	7%
169	Gianotti-Crosti Syndrome	7%
170	Encephalomyelitis	7%
171	Prion Diseases	7%
172	Autonomic Dysreflexia	7%
173	Complex Regional Pain Syndromes	7%
174	Polycystic Kidney, Autosomal Dominant	6.7%
175	Spinal Muscular Atrophy	6.7%
176	Progressive Muscular Atrophy	6.7%
177	Craniosynostosis	6.6%
178	Syndactyly	6.6%
179	Brachycephaly	6.6%
180	Toxoplasmosis, Congenital	6.6%
181	Turner Syndrome	6.6%
182	Welander Distal Myopathy	6.5%
183	Meningoencephalitis	6.5%
184	Anemia, Neonatal	6.4%
185	Persistent Fetal Circulation Syndrome	6.4%
186	Arthrogryposis	6.4%
187	Choanal Atresia	6.4%
188	Tracheobronchomegaly	6.4%
189	Laryngocele	6.4%
190	Umbilical hernia	6.4%
191	Amino Acid Metabolism, Inborn Errors	6.3%
192	Carbohydrate Metabolism, Inborn Errors	6.3%
193	Metal Metabolism, Inborn Errors	6.3%
194	Progeria	6.3%
195	Lysosomal Storage Diseases	6.3%
196	Cytochrome-c Oxidase Deficiency	6.3%
197	Peroxisomal Disorders	6.3%
198	Choledochal Cyst	6.3%
199	Hermaphroditism	6.3%
200	Disorders of Sex Development	6.3%
201	Optic Atrophy, Hereditary, Leber	6.3%
202	Spinal Cord Injuries	6.3%
203	Cryptorchidism	6.3%
204	Hypospadias	6.3%
205	Parkinson Disease	6.3%
206	Sickle Cell Trait	6.2%
207	Brain Diseases, Metabolic, Inborn	6.2%
208	Peripheral Nerve Injuries	6.2%
209	Lewy Body Disease	6.2%
210	Guillain-Barre Syndrome	6.1%
211	Myasthenia Gravis	6.1%
212	Asterixis	6.1%
213	Ballismus	6.1%
214	Lambert-Eaton Myasthenic Syndrome	6.1%
215	Antley-Bixler Syndrome Phenotype	6.1%
216	Noonan Syndrome	6.1%
217	Marchiafava-Bignami Disease	6%
218	Pneumocephalus	5.9%
219	Poliomyelitis	5.9%
220	Hyperkeratosis, Epidermolytic	5.9%
221	Myelitis, Transverse	5.9%
222	Friedreich Ataxia	5.9%
223	Galactosemias	5.8%
224	Urea Cycle Disorders, Inborn	5.8%
225	Tyrosinemias	5.8%
226	Progressive supranuclear palsy	5.8%
227	Acrocephalosyndactylia	5.7%
228	Laryngomalacia	5.7%
229	Neonatal Abstinence Syndrome	5.7%
230	Pectus carinatum	5.7%
231	Bladder Exstrophy	5.6%
232	Epispadias	5.6%
233	Chronic Fatigue Syndrome	5.6%
234	Cutis Laxa	5.6%
235	Fetal Growth Retardation	5.6%
236	Multicystic Dysplastic Kidney	5.6%
237	Retinitis Pigmentosa	5.6%
238	Fetal Hypoxia	5.6%
239	Fetal Alcohol Spectrum Disorders	5.6%
240	Pigmentary retinopathy	5.6%
241	Sleep Disorders, Circadian Rhythm	5.6%
242	Porokeratosis	5.6%
243	Keratoderma, Palmoplantar	5.6%
244	Leukoencephalitis, Acute Hemorrhagic	5.6%
245	Syphilis, Congenital	5.5%
246	Dyskinesia, Drug-Induced	5.5%
247	Opsoclonus-Myoclonus Syndrome	5.5%
248	Botulism	5.4%
249	Striatonigral Degeneration	5.4%
250	Miller Fisher Syndrome	5.3%
251	Neuromyelitis Optica	5.3%
252	Leukomalacia, Periventricular	5.3%
253	Neuroleptic Malignant Syndrome	5.3%
254	Myelinolysis, Central Pontine	5.3%
255	Klinefelter Syndrome	5.3%
256	Epidural Abscess	5.2%
257	Olfactory Nerve Injuries	5.2%
258	Acute Chest Syndrome	5.2%
259	Familial Periodic Paralysis	5.1%
260	Brain Diseases	5.1%
261	Dysautonomia	5.1%
262	Meningitis	5.1%
263	Movement Disorders	5.1%
264	Pachymeningitis	5.1%
265	Spinal Cord Diseases	5.1%
266	Vagus Nerve Disorder	5.1%
267	Glossopharyngeal Neuralgia	5.1%
268	Abducens Nerve Diseases	5.1%
269	Heavy Metal Poisoning, Nervous System	5.1%
270	Neuromuscular Junction Diseases	5.1%
271	Tauopathies	5.1%
272	Trochlear Nerve Diseases	5.1%
273	Peripheral Nervous System Diseases	5.1%
274	Cleft Palate	5.1%
275	Myelitis	5.1%
276	Progressive bulbar palsy	5.1%
277	Bulbar palsy	5.1%
278	Glycogen storage disease type II	5.1%
279	Jaw Abnormalities	5.1%
280	MPTP Poisoning	5%
281	Causalgia	5%
282	Porphyrias, Hepatic	5%
283	Congenital Hyperinsulinism	5%
284	Chorioamnionitis	5%
285	Deformity	5%
286	Peutz-Jeghers Syndrome	5%
287	Thrombasthenia	5%
288	Antithrombin III Deficiency	5%
289	Protein C Deficiency	5%
290	Afibrinogenemia	4.9%
291	Factor VII Deficiency	4.9%
292	Factor X Deficiency	4.9%
293	Factor XII Deficiency	4.9%
294	Hemophilia A	4.9%
295	Activated Protein C Resistance	4.9%
296	Factor II deficiency	4.9%
297	Factor VIII Deficiency	4.9%
298	Factor V deficiency	4.9%
299	Factor XI Deficiency	4.9%
300	Hypoprothrombinemias	4.9%
301	Akathisia, Drug-Induced	4.9%
302	Fanconi Anemia	4.9%
303	Anemia, Diamond-Blackfan	4.9%
304	Shy-Drager Syndrome	4.8%
305	Encephalomyelitis, Acute Disseminated	4.8%
306	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.8%
307	Amelia	4.7%
308	Arachnodactyly	4.7%
309	Ectopia Cordis	4.7%
310	Ectromelia	4.7%
311	Hemimelia	4.7%
312	Phocomelia	4.7%
313	Sirenomelia	4.7%
314	Polydactyly	4.7%
315	Brachydactyly	4.7%
316	Plagiocephaly	4.7%
317	Lower Extremity Deformities, Congenital	4.7%
318	Upper Extremity Deformities, Congenital	4.7%
319	Single umbilical artery	4.7%
320	Homocystinuria	4.7%
321	Facial Nerve Injuries	4.7%
322	Leukoencephalopathy, Progressive Multifocal	4.7%
323	Horner Syndrome	4.7%
324	Leigh Disease	4.7%
325	Hyperphosphaturia	4.7%
326	Multiple Endocrine Neoplasia	4.6%
327	Central Nervous System Infection	4.6%
328	Myopathy	4.6%
329	Optic Neuropathy	4.6%
330	Congenital Hypothyroidism	4.5%
331	Dermatitis, Atopic	4.5%
332	Facial Nerve Diseases	4.5%
333	Craniocerebral Trauma	4.5%
334	Parasomnia	4.5%
335	Dyssomnias	4.5%
336	Brain Injuries	4.5%
337	Brain Neoplasms	4.4%
338	Multiple Sclerosis	4.4%
339	Spinal Cord Neoplasms	4.4%
340	Vestibulocochlear Nerve Diseases	4.4%
341	Decerebrate State	4.4%
342	Hemiparesis	4.4%
343	Meningism	4.4%
344	Paresis	4.4%
345	Seizures	4.4%
346	Sensation Disorders	4.4%
347	Central Nervous System Neoplasms	4.4%
348	Complex partial seizures	4.4%
349	Monoparesis	4.4%
350	Neurogenic Inflammation	4.4%
351	Gait Disorders, Neurologic	4.4%
352	Neuromuscular Manifestations	4.4%
353	Sweating, Gustatory	4.4%
354	Auriculotemporal Syndrome	4.4%
355	Poland Syndrome	4.3%
356	Myasthenia Gravis, Autoimmune, Experimental	4.3%
357	Vasculitis, Central Nervous System	4.3%
358	Jet Lag Syndrome	4.2%
359	Aortic coarctation	4.1%
360	Cor Triatriatum	4.1%
361	Coronary Vessel Anomalies	4.1%
362	Dental Enamel Hypoplasia	4.1%
363	Patent ductus arteriosus	4.1%
364	Ebstein Anomaly	4.1%
365	Heart Septal Defects	4.1%
366	Hypodontia	4.1%
367	Macrostomia	4.1%
368	Microstomia	4.1%
369	Tetralogy of Fallot	4.1%
370	Transposition of Great Vessels	4.1%
371	Hypoplastic Left Heart Syndrome	4.1%
372	May-Thurner Syndrome	4.1%
373	Reflex Sympathetic Dystrophy	4.1%
374	Subdural Effusion	4.1%
375	Parkinsonian Disorders	4.1%
376	Nocturnal Myoclonus Syndrome	4.1%
377	Craniofacial Dysostosis	4.1%
378	Wolff-Parkinson-White Syndrome	4.1%
379	Behcet Syndrome	4.1%
380	Limbic Encephalitis	4%
381	Ophthalmia Neonatorum	4%
382	Lupus Vasculitis, Central Nervous System	4%
383	Alkaptonuria	4%
384	Glycogen Storage Disease	4%
385	Hypophosphatasia	4%
386	Propionic acidemia	4%
387	Dihydropyrimidine Dehydrogenase Deficiency	4%
388	Cystinosis	4%
389	Brain Abscess	4%
390	Ophthalmoplegia	4%
391	External Ophthalmoplegia	4%
392	Mucopolysaccharidosis III	4%
393	Pupil Disorders	4%
394	Neurobehavioral Manifestations	4%
395	Paraneoplastic Encephalomyelitis	3.9%
396	Uveomeningoencephalitic Syndrome	3.9%
397	Sturge-Weber Syndrome	3.9%
398	Vertigo	3.9%
399	Alcohol-Induced Disorders, Nervous System	3.9%
400	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.9%
401	Hydrops Fetalis	3.8%
402	Gaucher Disease	3.8%
403	Epilepsy, Post-Traumatic	3.7%
404	MELAS Syndrome	3.7%
405	Long QT Syndrome	3.7%
406	Platybasia	3.7%
407	Tricuspid Atresia	3.7%
408	Arrhythmogenic Right Ventricular Dysplasia	3.7%
409	Gonadal Dysgenesis	3.7%
410	Bronchomalacia	3.7%
411	Adrenogenital Syndrome	3.7%
412	Tracheomalacia	3.7%
413	Ovotesticular Disorders of Sex Development	3.7%
414	Scrapie	3.7%
415	Central Cord Syndrome	3.7%
416	Presenile dementia	3.6%
417	Senile dementia	3.6%
418	Meningitis, Bacterial	3.6%
419	Meningitis, Fungal	3.6%
420	Vocal Cord Paralysis	3.6%
421	Chorea	3.6%
422	Acrodynia	3.6%
423	Paralysis, Obstetric	3.6%
424	Retinopathy of Prematurity	3.6%
425	Bronchopulmonary Dysplasia	3.6%
426	Voice Disorders	3.5%
427	Voice Disturbance	3.5%
428	Hypolipoproteinemias	3.5%
429	Papillon-Lefevre Disease	3.5%
430	Hyperlipidemia, Familial Combined	3.5%
431	Hyperlipoproteinemia Type III	3.5%
432	Hypokalemic periodic paralysis	3.5%
433	Micrognathism	3.4%
434	Pierre Robin Syndrome	3.4%
435	Nephroblastoma	3.4%
436	Kernicterus	3.4%
437	Dementia, Vascular	3.3%
438	Brain Hemorrhage, Traumatic	3.3%
439	Hyperandrogenism	3.3%
440	Amblyopia	3.2%
441	Alcohol Withdrawal Seizures	3.2%
442	Paraneoplastic Cerebellar Degeneration	3.2%
443	Cerebrospinal Fluid Otorrhea	3.2%
444	Cerebrospinal Fluid Rhinorrhea	3.2%
445	Neuritis, Autoimmune, Experimental	3.2%
446	Gait Ataxia	3.2%
447	Meige Syndrome	3.2%
448	Brachial Plexus Neuritis	3.2%
449	Neuralgic Amyotrophy	3.2%
450	Cerebral Ventriculitis	3.2%
451	Respiratory Distress Syndrome, Newborn	3.2%
452	Adenomatous Polyposis Coli	3.2%
453	Retrognathia	3.2%
454	Lactose Intolerance	3.1%
455	Variegate Porphyria	3.1%
456	Acute intermittent porphyria	3.1%
457	Porphyria Cutanea Tarda	3.1%
458	Hyperhomocysteinemia	3.1%
459	Renal Aminoacidurias	3.1%
460	Fanconi Syndrome	3.1%
461	Pseudohypoaldosteronism	3.1%
462	Liddle Syndrome	3.1%
463	Niemann-Pick Disease, Type C	3.1%
464	Hyperlipoproteinemia Type IV	3.1%
465	Hyperlipoproteinemia Type V	3.1%
466	Tay-Sachs Disease	3.1%
467	Reflex, Abnormal	3.1%
468	Hyporeflexia	3.1%
469	Hyperreflexia	3.1%
470	Carotid Artery Injuries	3.1%
471	Brain Death	3%
472	Coma, Post-Head Injury	3%
473	Cerebellar Neoplasms	3%
474	Akinetic Mutism	2.9%
475	Anoxic Encephalopathy	2.9%
476	Arachnoiditis	2.9%
477	Basal Ganglia Diseases	2.9%
478	Brain Damage, Chronic	2.9%
479	Cerebellar Diseases	2.9%
480	Encephalitis	2.9%
481	Encephalomalacia	2.9%
482	Epilepsy	2.9%
483	Hydrocephalus	2.9%
484	Congenital Hydrocephalus	2.9%
485	Hypothalamic Diseases	2.9%
486	Aseptic Meningitis	2.9%
487	Neuritis	2.9%
488	Polyneuritis	2.9%
489	Radiculitis	2.9%
490	Syringomyelia	2.9%
491	Thalamic Diseases	2.9%
492	Intracranial Hypertension	2.9%
493	Polyneuropathy	2.9%
494	Mononeuritis	2.9%
495	Aura	2.9%
496	Leukoencephalopathy	2.9%
497	Essential Tremor	2.9%
498	Neuroaxonal Dystrophies	2.9%
499	Familial Tremor	2.9%
500	Headache Disorders	2.9%
501	Mononeuropathies	2.9%
502	Intracranial Hypotension	2.9%
503	Brachial Plexus Neuropathies	2.9%
504	Radiculopathy	2.9%
505	Mononeuropathy Multiplex	2.9%
506	Nerve Root Compression	2.9%
507	Brain Edema	2.9%
508	Brain Hypoxia	2.9%
509	Aqueductal Stenosis	2.9%
510	Pneumorrhachis	2.9%
511	Writer's Cramp	2.9%
512	Prognathism	2.9%
513	Denys-Drash Syndrome	2.9%
514	Akathisia	2.9%
515	Restlessness	2.9%
516	Psychomotor Agitation	2.9%
517	Gout	2.9%
518	Glycogen Storage Disease Type I	2.8%
519	Glycogen Storage Disease Type V	2.8%
520	Multiple Endocrine Neoplasia Type 1	2.8%
521	Pseudohypoparathyroidism	2.8%
522	Creutzfeldt-Jakob disease	2.8%
523	Basal Ganglia Cerebrovascular Disease	2.8%
524	Brain Injuries, Diffuse	2.8%
525	Traumatic Brain Injury	2.8%
526	Renal tubular acidosis	2.8%
527	Cerebellar Ataxia	2.8%
528	Supratentorial Neoplasms	2.8%
529	Torticollis	2.8%
530	Multiple Sclerosis, Chronic Progressive	2.8%
531	Multiple Sclerosis, Relapsing-Remitting	2.8%
532	Nesidioblastosis	2.8%
533	Optic Nerve Glioma	2.8%
534	Tarsal Tunnel Syndrome	2.7%
535	Cauda Equina Syndrome	2.7%
536	Posterior Leukoencephalopathy Syndrome	2.7%
537	Posterior reversible encephalopathy syndrome	2.7%
538	Tuberculosis, Meningeal	2.7%
539	Aortopulmonary Septal Defect	2.7%
540	Double Outlet Right Ventricle	2.7%
541	Endocardial Cushion Defects	2.7%
542	Myocardial bridging	2.7%
543	Aorticopulmonary Septal Defect	2.7%
544	Alice in Wonderland Syndrome	2.6%
545	Vertebral Artery Dissection	2.6%
546	Amnesia, Transient Global	2.6%
547	Gait Apraxia	2.6%
548	Brain Diseases, Metabolic	2.6%
549	Cerebrovascular Disorders	2.6%
550	Myositis	2.6%
551	Optic Atrophy	2.6%
552	Optic Neuritis	2.6%
553	Papilledema	2.6%
554	Strabismus	2.6%
555	Tolosa-Hunt Syndrome	2.6%
556	Cerebrovascular Insufficiency	2.6%
557	Isaacs syndrome	2.6%
558	Arsenic Poisoning	2.6%
559	Dementia	2.6%
560	Myotonic Disorders	2.6%
561	Central Nervous System Fungal Infections	2.6%
562	Conus Medullaris Syndrome	2.6%
563	Spinal Cord Vascular Diseases	2.6%
564	Toxoplasmosis, Cerebral	2.5%
565	Diabetic Neuropathies	2.5%
566	Facial Injuries	2.5%
567	Facial Neuralgia	2.5%
568	Acoustic Neuroma	2.5%
569	Diabetic Amyotrophy	2.5%
570	Diabetic Autonomic Neuropathy	2.5%
571	Sleep Talking	2.5%
572	Manganese Poisoning	2.5%
573	Sleep Disorders, Intrinsic	2.5%
574	Orthostatic intolerance	2.5%
575	Anosmia	2.5%
576	Ataxia	2.5%
577	Athetosis	2.5%
578	Catalepsy	2.5%
579	Dystonia	2.5%
580	Hemiplegia	2.5%
581	Locked-In Syndrome	2.5%
582	Meningeal Neoplasms	2.5%
583	Muscle Hypertonia	2.5%
584	Muscle hypotonia	2.5%
585	Myoclonus	2.5%
586	Myotonia	2.5%
587	Neuralgia	2.5%
588	Paraplegia	2.5%
589	Pseudobulbar Palsy	2.5%
590	Quadriplegia	2.5%
591	Spasm	2.5%
592	Spastic Paraplegia	2.5%
593	Status Epilepticus	2.5%
594	Taste Disorders	2.5%
595	Tremor	2.5%
596	Monoplegia	2.5%
597	Hypokinesia	2.5%
598	Paraparesis	2.5%
599	Bradykinesia	2.5%
600	Waxy flexibility	2.5%
601	Action Tremor	2.5%
602	Resting Tremor	2.5%
603	Dysosmia	2.5%
604	Quadriparesis	2.5%
605	Mercury Poisoning, Nervous System	2.5%
606	Olfaction Disorders	2.5%
607	Myokymia	2.5%
608	Lead Poisoning, Nervous System	2.5%
609	Vestibular Neuronitis	2.5%
610	Somatosensory Disorders	2.5%
611	Neuropathic pain	2.5%
612	Hyperkinesia	2.5%
613	Intention tremor	2.5%
614	Hypoalphalipoproteinemias	2.5%
615	Brain Concussion	2.5%
616	Carpal Tunnel Syndrome	2.4%
617	Vascular Headaches	2.4%
618	Mandibulofacial Dysostosis	2.4%
619	Romano-Ward Syndrome	2.4%
620	neurofibroma	2.4%
621	Hypoxia-Ischemia, Brain	2.4%
622	Sciatica	2.4%
623	Tardive Dyskinesia	2.4%
624	Persistent Vegetative State	2.4%
625	Glycosuria, Renal	2.3%
626	Familial Hypophosphatemic Rickets	2.3%
627	Hand-Arm Vibration Syndrome	2.3%
628	Myoclonic Epilepsy	2.3%
629	Epilepsy, Temporal Lobe	2.3%
630	Epilepsy, Rolandic	2.3%
631	Benign Rolandic Epilepsy	2.3%
632	Vision Disorders	2.3%
633	Metamorphopsia	2.3%
634	Visual Impairment	2.3%
635	Fibromyalgia	2.3%
636	Optic Neuropathy, Ischemic	2.3%
637	Anterior Ischemic Optic Neuropathy	2.3%
638	Central Nervous System Bacterial Infections	2.3%
639	Medial Tibial Stress Syndrome	2.3%
640	Mitochondrial Encephalomyopathies	2.3%
641	Facial Hemiatrophy	2.2%
642	Melkersson-Rosenthal Syndrome	2.2%
643	Mitochondrial Myopathies	2.2%
644	Pituitary Adenoma	2.2%
645	Pituitary Neoplasms	2.2%
646	Anisocoria	2.2%
647	Confusion	2.2%
648	Facial paralysis	2.2%
649	Lethargy	2.2%
650	Memory Disorders	2.2%
651	Muscle Cramp	2.2%
652	Perceptual Disorders	2.2%
653	Psychomotor Disorders	2.2%
654	Tonic Pupil	2.2%
655	Eosinophilia-Myalgia Syndrome	2.2%
656	Anhedonia	2.2%
657	Disorientation	2.2%
658	Facial Paresis	2.2%
659	Memory Loss	2.2%
660	Hemisensory Neglect	2.2%
661	Dysacusis	2.2%
662	Sleep Bruxism	2.2%
663	Muscular Atrophy	2.2%
664	Respiratory Paralysis	2.2%
665	Tetany	2.2%
666	Cystinuria	2.2%
667	Giant Cell Arteritis	2.1%
668	Temporal Arteritis	2.1%
669	Meningitis, Cryptococcal	2.1%
670	Meningitis, Listeria	2.1%
671	Meningitis, Haemophilus	2.1%
672	Meningitis, Pneumococcal	2.1%
673	Frontotemporal dementia	2.1%
674	Auditory Perceptual Disorders	2.1%
675	Basal Ganglia Hemorrhage	2%
676	Consciousness Disorders	2%
677	Mental Retardation	2%
678	Muscle Weakness	2%
679	Depressed Level of Consciousness	2%
680	Mental deficiency	2%
681	Intellectual Disability	2%
682	Arthritis, Gouty	2%
683	Bell Palsy	2%
684	Catatonia	2%
685	Cubital Tunnel Syndrome	2%
686	Subarachnoid Hemorrhage, Traumatic	2%
687	Carotid Artery, Internal, Dissection	2%
688	Herpes Zoster Oticus	2%
689	Diffuse Axonal Injury	2%
690	Truncus Arteriosus, Persistent	2%
691	Brain Stem Neoplasms	2%
692	Goldenhar Syndrome	2%
693	Aphonia	2%
694	Sleep Deprivation	2%
695	Dysphonia	2%
696	Arteriovenous fistula	2%
697	Hyaline Membrane Disease	1.9%
698	Subacute Sclerosing Panencephalitis	1.9%
699	Cerebral Palsy	1.9%
700	Epilepsies, Partial	1.9%
701	Epilepsy, Generalized	1.9%
702	Pseudotumor Cerebri	1.9%
703	Sciatic Neuropathy	1.9%
704	Hypertensive Encephalopathy	1.9%
705	Ulnar Neuropathies	1.9%
706	Lesion of Sciatic Nerve	1.9%
707	Simple Partial Seizures	1.9%
708	Epilepsy, Reflex	1.9%
709	Ulnar Neuritis	1.9%
710	Radial nerve compression	1.9%
711	Radial Tunnel Syndrome	1.9%
712	Peroneal Neuropathies	1.9%
713	Radial Neuropathy	1.9%
714	Median Neuropathy	1.9%
715	Sciatic Nerve Palsy	1.9%
716	Femoral Neuropathy	1.9%
717	Tibial Neuropathy	1.9%
718	Ulnar Nerve Palsy	1.9%
719	Postural Orthostatic Tachycardia Syndrome	1.9%
720	Radial nerve palsy	1.9%
721	Headache Disorders, Primary	1.9%
722	Headache Disorders, Secondary	1.9%
723	Medication overuse headache	1.9%
724	Juvenile Myoclonic Epilepsy	1.8%
725	Myoclonic Epilepsies, Progressive	1.8%
726	Pituitary Apoplexy	1.8%
727	Talipes	1.8%
728	Myalgia	1.8%
729	Brain Contusion	1.8%
730	Brain Infarction	1.8%
731	Putaminal Hemorrhage	1.7%
732	Pituitary Diseases	1.7%
733	Hoarseness	1.6%
734	Thoracic Outlet Syndrome	1.6%
735	Alcohol Withdrawal Delirium	1.6%
736	Carotid Artery Diseases	1.6%
737	Brain Ischemia	1.6%
738	Esotropia	1.6%
739	Exotropia	1.6%
740	Hypotension, Orthostatic	1.6%
741	Sleep Apnea Syndromes	1.6%
742	Cerebrovascular accident	1.6%
743	Polymyositis	1.6%
744	Kluver-Bucy Syndrome	1.6%
745	Vasospasm, Intracranial	1.6%
746	Spinal Cord Ischemia	1.6%
747	Intracranial Arterial Diseases	1.6%
748	Post-Exercise Hypotension	1.6%
749	Kearns-Sayre syndrome	1.6%
750	Disorders of Excessive Somnolence	1.6%
751	Sleep Initiation and Maintenance Disorders	1.6%
752	Night Terrors	1.6%
753	Somnambulism	1.6%
754	Trigeminal Nerve Disorder	1.6%
755	Transient Insomnia	1.6%
756	Sleep Paralysis	1.6%
757	Chronic Insomnia	1.6%
758	REM Sleep Behavior Disorder	1.6%
759	Hypersomnia	1.6%
760	Hematoma, Subdural	1.6%
761	Hematoma, Epidural, Cranial	1.6%
762	Dysgeusia	1.6%
763	Formication	1.6%
764	Hyperalgesia	1.6%
765	Hyperesthesia	1.6%
766	Hypesthesia	1.6%
767	Language Disorders	1.6%
768	Numbness	1.6%
769	Paresthesia	1.6%
770	Paraparesis, Spastic	1.6%
771	Trismus	1.6%
772	Epilepsia Partialis Continua	1.6%
773	Hypogeusia	1.6%
774	Meningeal Carcinomatosis	1.6%
775	Brown-Sequard Syndrome	1.6%
776	Lockjaw	1.6%
777	Allodynia	1.6%
778	Lead Poisoning, Nervous System, Childhood	1.6%
779	Lead Poisoning, Nervous System, Adult	1.6%
780	Ageusia	1.6%
781	Alexia	1.6%
782	Dyslexia	1.6%
783	Tuberculosis, Central Nervous System	1.6%
784	Choroid Plexus Papilloma	1.6%
785	Infarction, Middle Cerebral Artery	1.6%
786	Infarction, Anterior Cerebral Artery	1.6%
787	Infarction, Posterior Cerebral Artery	1.6%
788	Congenital clubfoot	1.5%
789	Vertical Talus	1.5%
790	Eye Injuries	1.4%
791	Moyamoya Disease	1.4%
792	Neurofibrosarcoma	1.4%
793	Orbital Myositis	1.4%
794	West Nile Fever	1.4%
795	Diplopia	1.4%
796	Muscle Rigidity	1.4%
797	Muscle Spasticity	1.4%
798	Scotoma	1.4%
799	Photophobia	1.4%
800	Cogwheel Rigidity	1.4%
801	Hemifacial Spasm	1.4%
802	Amaurosis	1.4%
803	Blindness	1.4%
804	Nuchal Rigidity	1.4%
805	Reye Syndrome	1.4%
806	Neuroaspergillosis	1.4%
807	Pyomyositis	1.4%
808	Cerebral Infarction	1.4%
809	Brain Stem Infarctions	1.4%
810	Intracranial Embolism and Thrombosis	1.4%
811	Hepatic Encephalopathy	1.4%
812	Agnosia	1.4%
813	Apraxias	1.4%
814	Hallucinations	1.4%
815	Hemianopsia	1.4%
816	Hyperacusis	1.4%
817	Tinnitus	1.4%
818	Visual Agnosia	1.4%
819	Anosognosia	1.4%
820	Wernicke-Korsakoff Syndrome	1.4%
821	Phonophobia	1.4%
822	Hearing Loss	1.4%
823	Sarcopenia	1.4%
824	Cortical Dysplasia	1.4%
825	Malformations of Cortical Development	1.4%
826	Polyradiculopathy	1.3%
827	Post-Traumatic Headache	1.3%
828	Tension Headache	1.3%
829	Epilepsy, Complex Partial	1.3%
830	Migraine Disorders	1.3%
831	Abdominal Migraine	1.3%
832	Status Migrainosus	1.3%
833	Cervicogenic Headache	1.3%
834	Pseudorabies	1.3%
835	Amnesia	1.3%
836	Delirium	1.3%
837	Dissociative Amnesia	1.3%
838	Color blindness	1.3%
839	Global Amnesia	1.3%
840	Meningioma	1.3%
841	Neurosyphilis	1.2%
842	Lateral Medullary Syndrome	1.2%
843	Hematoma, Subdural, Intracranial	1.2%
844	Hematoma, Subdural, Chronic	1.2%
845	Hematoma, Subdural, Acute	1.2%
846	Empty Sella Syndrome	1.2%
847	Hyperpituitarism	1.2%
848	Hypopituitarism	1.2%
849	Hypophysitis	1.2%
850	Cerebral Arterial Diseases	1.1%
851	Vertebrobasilar Insufficiency	1.1%
852	Anterior Spinal Artery Syndrome	1.1%
853	Basilar Artery Stenosis	1.1%
854	Vertebral Artery Stenosis	1.1%
855	Sleep Apnea, Obstructive	1.1%
856	Sleep Apnea, Central	1.1%
857	Intracranial Hemorrhage, Hypertensive	1.1%
858	Transient Cerebral Ischemia	1.1%
859	Narcolepsy	1.1%
860	Trigeminal Neuralgia	1.1%
861	Kleine-Levin Syndrome	1.1%
862	Agraphia	1.1%
863	Anomia	1.1%
864	Cluttering	1.1%
865	Language Development Disorders	1.1%
866	Speech Disorders	1.1%
867	Syncope	1.1%
868	Stupor	1.1%
869	Dysgraphia	1.1%
870	Presyncope	1.1%
871	Dyslalia	1.1%
872	Wernicke Encephalopathy	1.1%
873	AIDS Dementia Complex	1.1%
874	Phantom pain	1.1%
875	Phantom Limb Pain	1.1%
876	Lyme Neuroborreliosis	1.1%
877	Cluster Headache	1.1%
878	Migraine with Aura	1.1%
879	Familial Hemiplegic Migraine	1.1%
880	Chronic Paroxysmal Hemicrania	1.1%
881	SUNCT Syndrome	1.1%
882	Paroxysmal Hemicrania	1.1%
883	Waterhouse-Friderichsen Syndrome	1%
884	Eye Burns	1%
885	Malaria, Cerebral	1%
886	Carotid Stenosis	1%
887	Intracranial Aneurysm	1%
888	Neurocysticercosis	1%
889	Amaurosis Fugax	1%
890	Blindness, Cortical	1%
891	Dyscalculia	1%
892	Intracranial Arteriosclerosis	1%
893	Cerebral Atherosclerosis	1%
894	Subarachnoid Hemorrhage	1%
895	Cerebral Arteriosclerosis	1%
896	Cerebral Hemorrhage	1%
897	Cerebral Thrombosis	1%
898	Intracranial Embolism	1%
899	Intracranial Thrombosis	1%
900	Deafness	1%
901	Hearing Loss, Sudden	1%
902	Gerstmann Syndrome	1%
903	Hearing Loss, Bilateral	1%
904	Hearing Loss, High-Frequency	1%
905	Hearing Loss, Mixed Conductive-Sensorineural	1%
906	Prosopagnosia	1%
907	Apraxia, Ideomotor	1%
908	Charles Bonnet Syndrome	1%
909	Hearing Loss, Unilateral	1%
910	Complete Hearing Loss	1%
911	Alien Hand Syndrome	1%
912	Deaf Mutism	1%
913	Hyperprolactinemia	0.9%
914	Subclavian Steal Syndrome	0.9%
915	Pick Disease of the Brain	0.9%
916	Dermatomyositis	0.9%
917	Cataplexy	0.9%
918	Aphasia	0.9%
919	Articulation Disorders	0.9%
920	Echolalia	0.9%
921	Stuttering	0.9%
922	Dysphasia	0.9%
923	Corneal Scar	0.9%
924	Retrograde amnesia	0.9%
925	Amnesia, Anterograde	0.9%
926	Carotid Artery Thrombosis	0.9%
927	Mutism	0.8%
928	Selective Mutism	0.8%
929	Acromegaly	0.8%
930	Cerebral Amyloid Angiopathy	0.8%
931	Sinus Thrombosis, Intracranial	0.8%
932	Dysarthria	0.8%
933	Corneal Perforation	0.7%
934	Alexia, Pure	0.7%
935	Cavernous Sinus Thrombosis	0.7%
936	Sagittal Sinus Thrombosis	0.7%
937	Prolactinoma	0.6%
938	Growth Hormone-Secreting Pituitary Adenoma	0.6%
939	Nelson Syndrome	0.6%

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