MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Deglutition Disorders

(UMLS:C0011168)

Definition:: Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.
UMLS ID:: C0011168
MeSH ID:: D003680

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.119

Classification 2:

Name:

Otorhinolaryngologic Diseases
MeSH Tree Number(s):: C09.775.174

Synonym(s)

Deglutition Disorders

Can't get food down

Cannot get food down

DYSPHAGIA

Deglutition disorders

Difficulty Swallowing

Difficulty in swallowing

Difficulty swallowing

Difficulty;swallowing

10.

Dysphagia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Alendronate	12730757	CTD
2	Atracurium	10754616	CTD
3	Benztropine	2224229 11569473 18305296	CTD
4	Biperiden	2710809	CTD
5	Budesonide	14641354	CTD
6	Bupropion	17218049	CTD
7	Chlorpromazine	4247303	CTD
8	Cisapride	7723193	CTD
9	Clozapine	7962689	CTD
10	Cocaine	11704715	CTD
11	Cytarabine	4518764	CTD
12	Diazepam	1484540	CTD
13	Digoxin	2039889 3742345	CTD
14	Diphenhydramine	2735633	CTD
15	Disulfiram	19224591	CTD
16	Donepezil	14731314	CTD
17	Ergotamine	6807440	CTD
18	Fluspirilene	2224229	CTD
19	Fosinopril	17245835	CTD
20	Furosemide	2486385	CTD
21	Haloperidol	View details 8919580 17024549 17484951 19047493	CTD
22	Hydroxychloroquine	17803043	CTD
23	Levamisole	16862045	CTD
24	Lithium Carbonate	963486 6288882	CTD
25	Lithium	4062531	CTD
26	Lorazepam	17484951	CTD
27	Maprotiline	6470193	CTD
28	Methotrexate	16314998 18191947	CTD
29	Methysergide	6807440	CTD
30	Metoclopramide	View details 601923 1484540 5440179 7125429 12752854	CTD
31	Metronidazole	14676060 15960179	CTD
32	Midazolam	17604593	CTD
33	N(1),N(11)-diethylnorspermine	9387045	CTD
34	Omeprazole	10566755	CTD
35	Penicillamine	View details 122656 287196 745827 2025947 6830075	CTD
36	Perphenazine	48972	CTD
37	Procainamide	7687390	CTD
38	Prochlorperazine	20486582	CTD
39	Pyridoxine	20167372	CTD
40	Risperidone	11569473 14731314	CTD
41	Tacrolimus	12819864 17484951	CTD
42	Tetrabenazine	132600	CTD
43	Thiethylperazine	16101941	CTD
44	Thiothixene	6470193	CTD
45	Trifluoperazine	8873877	CTD
46	Valproic Acid	9097225 20204907	CTD
47	Vecuronium Bromide	10754616	CTD
48	Vincristine	10942065 20167372	CTD
49	antimicrobial peptide IB-367	12872363	CTD
50	dichloralantipyrine	4247303	CTD
51	fluphenazine depot	8919580	CTD
52	gemcitabine	9500323	CTD
53	triclofos	4247303	CTD
54	ziprasidone	18305296	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Esophagitis	33.9%
2	Esophageal Stenosis	31.8%
3	Esophageal and Gastric Varices	27.1%
4	Esophageal Perforation	25%
5	Barrett Esophagus	24.1%
6	Mallory-Weiss Syndrome	23.6%
7	Esophageal Atresia	23.3%
8	Esophageal Neoplasms	21.1%
9	Gastroenteritis	20.9%
10	Intestinal Diseases	20.9%
11	Stomach Diseases	20.9%
12	Zollinger-Ellison syndrome	20.9%
13	Dysentery	20.3%
14	Enteritis	20.3%
15	Enterocolitis	20.3%
16	Gastritis	20.3%
17	Inflammatory Bowel Diseases	20.3%
18	Proctocolitis	18.9%
19	Pharyngeal Neoplasms	18.5%
20	Duodenitis	17.9%
21	Ileitis	17.9%
22	Erosive Duodenitis	17.9%
23	Colitis	17.6%
24	Duodenogastric Reflux	17.6%
25	Peptic Ulcer	17.6%
26	Proctitis	17.6%
27	Nasopharyngeal Neoplasms	17.5%
28	Nasopharyngitis	17.3%
29	Pharyngitis	16.9%
30	Gastrointestinal Neoplasms	16.7%
31	Colorectal Neoplasms	16%
32	Intestinal Neoplasms	15.6%
33	Stomach Neoplasms	15.6%
34	Gastrointestinal Hemorrhage	15.5%
35	Tuberculosis, Gastrointestinal	15.3%
36	Crohn Disease	15%
37	Duodenal Obstruction	15%
38	Enterocolitis, Neutropenic	15%
39	Necrotizing Enterocolitis	15%
40	Pouchitis	14.8%
41	Ear Diseases	14.6%
42	Appendicitis	14.1%
43	Cecal Neoplasms	14.1%
44	Duodenal Neoplasms	14.1%
45	Duodenal Ulcer	13.7%
46	Peptic Ulcer Perforation	13.7%
47	Gastric ulcer	13.7%
48	Cecal Diseases	13.6%
49	Colonic Diseases	13.6%
50	Ileal Diseases	13.6%
51	Intestinal Obstruction	13.6%
52	Intestinal Perforation	13.6%
53	Jejunal Diseases	13.6%
54	Pneumatosis Cystoides Intestinalis	13.6%
55	Rectal Diseases	13.6%
56	Gastric Dilatation	13.6%
57	Gastric outlet obstruction	13.6%
58	Cronkhite-Canada Syndrome	13.6%
59	Intestinal Polyposis	13.6%
60	Hypopharyngeal Neoplasms	13.4%
61	Hypopharyngeal Cancer	13.4%
62	Nasopharyngeal carcinoma	12.7%
63	Mesenteric vascular insufficiency	12.5%
64	Intestinal Atresia	12.3%
65	Mesenteric Vascular Occlusion	12.3%
66	Intestinal Fistula	12.2%
67	Enterocutaneous Fistula	12.2%
68	Biliary Tract Diseases	12.2%
69	Liver diseases	12.2%
70	Pancreatic Diseases	12.2%
71	Tonsillitis	12.2%
72	Rectal Fistula	12.1%
73	Anal Fistula	12.1%
74	Anus Neoplasms	12.1%
75	Sigmoid Neoplasms	12.1%
76	Enterocolitis, Pseudomembranous	11.9%
77	pseudomembranous colitis	11.9%
78	Dysentery, Bacillary	11.9%
79	Colonic Pseudo-Obstruction	11.8%
80	Appendiceal Neoplasms	11.6%
81	Colonic Neoplasms	11.6%
82	Rectal Neoplasms	11.6%
83	Laryngeal Diseases	11.3%
84	Nose Diseases	11.3%
85	Colitis, Ischemic	11.1%
86	Ear Neoplasms	11%
87	Tonsillar Neoplasms	10.9%
88	Gastrointestinal Stromal Tumors	10.7%
89	Intestinal Diseases, Parasitic	10.7%
90	Achlorhydria	10.2%
91	Labyrinthitis	10.2%
92	Gastric Antral Vascular Ectasia	10.2%
93	Colonic Diseases, Functional	10.1%
94	Fecal Incontinence	10.1%
95	Fecal Impaction	10.1%
96	Intussusception	10.1%
97	Megacolon	10.1%
98	Pyloric Stenosis	10.1%
99	Ileus	10.1%
100	Meconium ileus	10.1%
101	Adenomatous Polyposis Coli	10.1%
102	Peptic Ulcer Hemorrhage	10.1%
103	Gastroparesis	10.1%
104	Retropharyngeal Abscess	10.1%
105	Lemierre Syndrome	10%
106	Otosclerosis	9.3%
107	Tympanosclerosis	9.3%
108	Digestive System Neoplasms	9.1%
109	Anal Fissure	8.4%
110	Intestinal Pseudo-Obstruction	8.4%
111	Irritable Bowel Syndrome	8.4%
112	Superior Mesenteric Artery Syndrome	8.4%
113	Neurogenic Bowel	8.4%
114	Anal Ulcer	8.4%
115	Liver neoplasms	8.3%
116	Pancreatic Fistula	8.3%
117	Peritonsillar Abscess	8.2%
118	Melena	8.2%
119	Hematemesis	8%
120	Laryngeal neoplasm	8%
121	Hemorrhoids	7.7%
122	Afferent Loop Syndrome	7.6%
123	Celiac Disease	7.6%
124	Short Bowel Syndrome	7.6%
125	Sprue, Tropical	7.6%
126	Steatorrhea	7.6%
127	Rectocele	7.6%
128	Sprue	7.6%
129	Diverticulitis	7.5%
130	Dumping Syndrome	7.5%
131	Rectal Prolapse	7.5%
132	Tympanic Membrane Perforation	7.3%
133	Primary Ciliary Dyskinesia	7.2%
134	Biliary cirrhosis	7%
135	Granuloma, Lethal Midline	7%
136	Laryngeal Edema	7%
137	Nose Deformities, Acquired	7%
138	Otomycosis	7%
139	Congenital Microtia	7%
140	Bile Duct Diseases	7%
141	Cholelithiasis	7%
142	Chylous Ascites	7%
143	Fatty Liver	7%
144	Hepatitis	7%
145	Portal Hypertension	7%
146	Liver Cirrhosis	7%
147	Pancreatic Insufficiency	7%
148	Pancreatitis	7%
149	Pneumoperitoneum	7%
150	Focal Nodular Hyperplasia	7%
151	Hepatic Insufficiency	7%
152	Steatohepatitis	7%
153	Peritoneal Neoplasms	6.9%
154	Cochlear Diseases	6.8%
155	Otitis Externa	6.8%
156	Otitis Media	6.8%
157	Vestibular Diseases	6.8%
158	Endolymphatic Hydrops	6.8%
159	Cholecystolithiasis	6.8%
160	Bile Duct Neoplasms	6.7%
161	gallbladder neoplasm	6.7%
162	Paranasal Sinus Neoplasms	6.7%
163	Pruritus Ani	6.3%
164	Giardiasis	6.2%
165	Nose Neoplasms	6.1%
166	Diverticulum	6.1%
167	Diverticulosis	6.1%
168	Pancreatic Neoplasm	5.9%
169	Choledocholithiasis	5.9%
170	Choledochal Cyst	5.7%
171	Laryngitis	5.6%
172	Rhinitis	5.6%
173	Vocal Cord Dysfunction	5.6%
174	Meniere Disease	5.6%
175	Otitis Media with Effusion	5.6%
176	Laryngostenosis	5.6%
177	Nasal Polyps	5.6%
178	Liver Diseases, Parasitic	5.5%
179	Dysacusis	5.4%
180	Maxillary Sinus Neoplasms	5.4%
181	Fatty Liver, Alcoholic	5.4%
182	Hepatitis, Alcoholic	5.4%
183	Liver Cirrhosis, Alcoholic	5.4%
184	Hepatic Veno-Occlusive Disease	5.3%
185	Pancreatic Cyst	5.3%
186	Peliosis Hepatis	5.3%
187	Hepatopulmonary Syndrome	5.3%
188	Vestibulocochlear Nerve Diseases	5.2%
189	Anus, Imperforate	5.2%
190	Hemoperitoneum	5.2%
191	Hepatomegaly	5.2%
192	Mesenteric Panniculitis	5.2%
193	Panniculitis, Peritoneal	5.2%
194	Peritonitis	5.2%
195	Peritoneal Fibrosis	5.2%
196	Encapsulating Peritoneal Sclerosis	5.2%
197	Anorectal Malformations	5.2%
198	Biliary Fistula	5.1%
199	Gastric Fistula	5.1%
200	Hepatic Vein Thrombosis	5.1%
201	Liver Abscess	5.1%
202	Budd-Chiari Syndrome	5.1%
203	Croup	5.1%
204	Rhinitis, Vasomotor	5.1%
205	Peutz-Jeghers Syndrome	5%
206	Lactose Intolerance	5%
207	Choanal Atresia	4.7%
208	Voice Disorders	4.7%
209	Voice Disturbance	4.7%
210	Laryngocele	4.7%
211	Epistaxis	4.6%
212	Cholangitis	4.5%
213	Cholecystitis	4.5%
214	Cholestasis	4.5%
215	Common Bile Duct Diseases	4.5%
216	Hepatitis, Chronic	4.5%
217	Liver Failure	4.5%
218	Pancreatitis, Chronic	4.5%
219	Non-alcoholic Fatty Liver Disease	4.5%
220	Chronic active hepatitis	4.5%
221	Herpes Zoster Oticus	4.5%
222	Hepatocellular Adenoma	4.4%
223	Chemical and Drug Induced Liver Injury	4.2%
224	Vestibular Neuronitis	4.2%
225	Sinusitis	4.1%
226	Hepatorenal Syndrome	4.1%
227	Laryngospasm	4.1%
228	Hyperacusis	4%
229	Tinnitus	4%
230	Phonophobia	4%
231	Hearing Loss	4%
232	Laryngomalacia	4%
233	Granuloma, Laryngeal	3.9%
234	Vocal Cord Paralysis	3.9%
235	Acoustic Neuroma	3.9%
236	Liver Abscess, Amebic	3.9%
237	Liver Neoplasms, Experimental	3.8%
238	Cryptosporidiosis	3.8%
239	Hepatitis, Animal	3.6%
240	Hepatitis, Viral, Human	3.6%
241	Cystic Fibrosis	3.5%
242	Porphyrias, Hepatic	3.4%
243	Congenital Hyperinsulinism	3.4%
244	Vertigo	3.4%
245	Liver Cirrhosis, Experimental	3.4%
246	Pancreatic Pseudocyst	3.4%
247	Cholestasis, Extrahepatic	3.4%
248	Biliary Dyskinesia	3.4%
249	Cholangitis, Sclerosing	3.4%
250	Liver Failure, Acute	3.4%
251	Acalculous Cholecystitis	3.4%
252	End Stage Liver Disease	3.4%
253	Pancreatitis, Alcoholic	3.4%
254	Aphonia	3.4%
255	Dysphonia	3.4%
256	Mastoiditis	3.3%
257	Petrositis	3.3%
258	Deafness	3.3%
259	Hearing Loss, Sudden	3.3%
260	Hearing Loss, Bilateral	3.3%
261	Hearing Loss, High-Frequency	3.3%
262	Hearing Loss, Mixed Conductive-Sensorineural	3.3%
263	Hearing Loss, Unilateral	3.3%
264	Complete Hearing Loss	3.3%
265	Deaf Mutism	3.3%
266	Hepatitis B, Chronic	3%
267	Hepatitis C, Chronic	3%
268	Rhinoscleroma	3%
269	Carcinoma, Pancreatic Ductal	2.9%
270	Massive Hepatic Necrosis	2.8%
271	Emphysematous Cholecystitis	2.8%
272	Sphincter of Oddi Dysfunction	2.8%
273	Hay fever	2.8%
274	Rhinitis, Allergic, Perennial	2.8%
275	Fascioliasis	2.7%
276	Echinococcosis, Hepatic	2.7%
277	Chemical and Drug Induced Liver Injury, Chronic	2.7%
278	Reye Syndrome	2.7%
279	Autoimmune hepatitis	2.6%
280	Hoarseness	2.5%
281	insulinoma	2.4%
282	Gastrinoma	2.4%
283	Glucagonoma	2.4%
284	Nesidioblastosis	2.2%
285	Variegate Porphyria	2.2%
286	Acute intermittent porphyria	2.2%
287	Porphyria Cutanea Tarda	2.2%
288	Vipoma	2.2%
289	Hepatitis, Viral, Animal	2.1%
290	Hepatitis E	2.1%
291	Auditory Perceptual Disorders	2.1%
292	Hepatitis B	2%
293	Hepatitis C	2%
294	Hepatitis A	2%
295	Hepatic Encephalopathy	2%
296	Kartagener Syndrome	1.9%
297	Zellweger Syndrome	1.7%
298	Hepatolenticular Degeneration	1.5%
299	Rift Valley Fever	1.1%

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