MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pruritus Ani

(UMLS:C0033775)

Definition:: Intense chronic itching in the anal area.
UMLS ID:: C0033775
MeSH ID:: D011538

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.860.101.752

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.685.544

Synonym(s)

Pruritus Ani

Anal itch

Anal pruritus

Itching;anal

Itching;perianal

Itching;rectal

PRURITUS ANI

Perianal irritation

Perianal itch

10.

Perianal itching

11.

Pruritus ani

12.

Pruritus;perianal

13.

anal itch

14.

anal itching

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Isotretinoin	FAERS: 32	US FAERS
2	rofecoxib	FAERS: 12	US FAERS
3	Ciprofloxacin	FAERS: 3	US FAERS
4	Paroxetine	FAERS: 3	US FAERS
5	Rosuvastatin Calcium	FAERS: 2	US FAERS
6	Duloxetine Hydrochloride	FAERS: 1	US FAERS
7	Ezetimibe	FAERS: 1	US FAERS
8	Fluticasone-Salmeterol Drug Combination	FAERS: 1	US FAERS
9	Ibandronic Acid	FAERS: 1	US FAERS
10	Imiquimod	FAERS: 1	US FAERS
11	Mesalamine	FAERS: 1	US FAERS
12	Midazolam	FAERS: 1	US FAERS
13	Rifaximin	FAERS: 1	US FAERS
14	Valacyclovir	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Anal Fissure	33.3%
2	Anal Ulcer	33.3%
3	Proctitis	24.5%
4	Fecal Incontinence	24.3%
5	Pyoderma Gangrenosum	23.8%
6	Pruritus Vulvae	22.9%
7	Dysentery	20.6%
8	Enteritis	20.6%
9	Enterocolitis	20.6%
10	Inflammatory Bowel Diseases	20.6%
11	Lupus Erythematosus, Cutaneous	20.4%
12	Panniculitis	20.4%
13	Systemic Scleroderma	20.4%
14	Morphea	20.4%
15	Breast Diseases	20.1%
16	Dermatitis	20.1%
17	Exanthema	20.1%
18	Facial Dermatoses	20.1%
19	Hair Diseases	20.1%
20	Hand Dermatoses	20.1%
21	keratoacanthoma	20.1%
22	Keratosis	20.1%
23	Nail Diseases	20.1%
24	Photosensitivity Disorders	20.1%
25	Prurigo	20.1%
26	Pyoderma	20.1%
27	Rosacea	20.1%
28	Sebaceous Gland Diseases	20.1%
29	Skin Diseases, Vesiculobullous	20.1%
30	Skin Ulcer	20.1%
31	Sweat Gland Diseases	20.1%
32	Skin Diseases, Papulosquamous	20.1%
33	Skin Diseases, Vascular	20.1%
34	Acneiform Eruptions	20.1%
35	Ocular Rosacea	20.1%
36	Subcorneal pustular dermatosis	20.1%
37	Erythematotelangiectatic Rosacea	20.1%
38	Papulopustular Rosacea	20.1%
39	Chronic Actinic Dermatitis	20.1%
40	Anus Neoplasms	20%
41	Colorectal Neoplasms	20%
42	Acne Vulgaris	19.8%
43	Contact Dermatitis	19.8%
44	Eczema	19.8%
45	Erythema Multiforme	19.8%
46	Intertrigo	19.8%
47	Neurodermatitis	19.8%
48	Rhinophyma	19.8%
49	Perioral Dermatitis	19.8%
50	Acne	19.8%
51	Rectal Fistula	19.2%
52	Anal Fistula	19.2%
53	Cecal Diseases	19.1%
54	Colonic Diseases	19.1%
55	Ileal Diseases	19.1%
56	Intestinal Obstruction	19.1%
57	Intestinal Perforation	19.1%
58	Jejunal Diseases	19.1%
59	Pneumatosis Cystoides Intestinalis	19.1%
60	Cronkhite-Canada Syndrome	19.1%
61	Intestinal Polyposis	19.1%
62	Hemorrhoids	18.7%
63	Rectocele	18.4%
64	Rectal Prolapse	18.2%
65	Dermatitis, Phototoxic	17.5%
66	Pityriasis Lichenoides et Varioliformis Acuta	17.5%
67	Pityriasis Lichenoides	17.5%
68	Phototoxicity	17.5%
69	Proctocolitis	17.4%
70	Foot Ulcer	17.1%
71	Dermatitis, Atopic	17%
72	Epidermolysis Bullosa	17%
73	Duodenal Obstruction	17%
74	Zollinger-Ellison syndrome	17%
75	Duodenitis	16.5%
76	Ileitis	16.5%
77	Erosive Duodenitis	16.5%
78	Dermatitis Herpetiformis	16.1%
79	Xeroderma Pigmentosum	16%
80	Foot Diseases	15.9%
81	Acrodermatitis	15.8%
82	Sebaceous Gland Neoplasms	15.8%
83	Porokeratosis	15.8%
84	Gianotti-Crosti Syndrome	15.8%
85	Keratoderma, Palmoplantar	15.8%
86	Skin Abnormalities	15.3%
87	Skin Diseases, Infectious	15.3%
88	Skin Neoplasms	15.3%
89	Pigmentation Disorders	15.3%
90	Panniculitis, Lupus Erythematosus	15.3%
91	Intestinal Diseases, Parasitic	15.2%
92	Esophageal Diseases	15.1%
93	Gastroenteritis	15.1%
94	Stomach Diseases	15.1%
95	Intestinal Neoplasms	15.1%
96	Lipomatosis	15.1%
97	Erythema	15.1%
98	Necrolytic Migratory Erythema	15.1%
99	Cutaneous Fistula	15.1%
100	Nephrogenic Fibrosing Dermopathy	15.1%
101	Nephrogenic Systemic Fibrosis	15.1%
102	Mesenteric vascular insufficiency	14.9%
103	Necrobiosis Lipoidica Diabeticorum	14.8%
104	Intestinal Atresia	14.7%
105	Mesenteric Vascular Occlusion	14.7%
106	Colitis	14.7%
107	Duodenogastric Reflux	14.7%
108	Peptic Ulcer	14.7%
109	Intestinal Fistula	14.6%
110	Enterocutaneous Fistula	14.6%
111	Dermatitis, Irritant	14.6%
112	Acne Conglobata	14.6%
113	Dermatitis, Photoallergic	14.6%
114	Urticaria Pigmentosa	13.6%
115	Xeroderma	13.4%
116	Dermatomyositis	13.3%
117	Lupus Erythematosus, Discoid	13.2%
118	Scleroderma, Limited	13.2%
119	Anhidrosis	13.1%
120	Cholesteatoma	13.1%
121	Pressure Ulcer	13.1%
122	Folliculitis	13.1%
123	Foot Dermatoses	13.1%
124	Gynecomastia	13.1%
125	Hypertrichosis	13.1%
126	Hypohidrosis	13.1%
127	Hypotrichosis	13.1%
128	Leg Ulcer	13.1%
129	Miliaria	13.1%
130	Parakeratosis	13.1%
131	Parapsoriasis	13.1%
132	Pityriasis	13.1%
133	Psoriasis	13.1%
134	Sweet Syndrome	13.1%
135	Hidradenitis	13.1%
136	Onycholysis	13.1%
137	Miliaria Rubra	13.1%
138	Hyperpigmentation	13.1%
139	Lichenoid Eruptions	13.1%
140	Chloracne	13.1%
141	Erythema Induratum	12.8%
142	Cecal Neoplasms	12.4%
143	Duodenal Neoplasms	12.4%
144	Esophagitis	12.3%
145	Gastritis	12.3%
146	Gastrointestinal Neoplasms	12.2%
147	Dermatitis, Occupational	12.2%
148	Crohn Disease	12.1%
149	Enterocolitis, Neutropenic	12.1%
150	Necrotizing Enterocolitis	12.1%
151	Diaper Rash	12%
152	Cutis Laxa	12%
153	Mastocytosis	12%
154	Rectal Neoplasms	11.9%
155	Appendicitis	11.8%
156	Dermatitis, Allergic Contact	11.7%
157	Connective Tissue Diseases	11.7%
158	Papillon-Lefevre Disease	11.7%
159	Erythema Infectiosum	11.6%
160	Exanthema Subitum	11.6%
161	Erythema Nodosum	11.4%
162	Colonic Diseases, Functional	11.4%
163	Fecal Impaction	11.4%
164	Intussusception	11.4%
165	Megacolon	11.4%
166	Ileus	11.4%
167	Meconium ileus	11.4%
168	Ectodermal Dysplasia	11.3%
169	Aplasia Cutis Congenita	11.3%
170	Gastrointestinal Hemorrhage	11.3%
171	Tuberculosis, Gastrointestinal	11.1%
172	Pseudoxanthoma Elasticum	11.1%
173	Toxic Epidermal Necrolysis	11%
174	Stevens-Johnson Syndrome	11%
175	Pouchitis	10.9%
176	Tinea Capitis	10.5%
177	Onychomycosis	10.5%
178	Acantholysis	10%
179	Breast Cyst	10%
180	Actinic keratosis	10%
181	Pemphigoid, Benign Mucous Membrane	10%
182	Pemphigus	10%
183	Piedra	10%
184	Sunburn	10%
185	Biliary Tract Diseases	9.9%
186	Liver diseases	9.9%
187	Pancreatic Diseases	9.9%
188	Argyria	9.9%
189	Hirsutism	9.9%
190	Lactation Disorder	9.9%
191	Mastitis	9.9%
192	Urticaria	9.9%
193	Granuloma Annulare	9.8%
194	Colonic Pseudo-Obstruction	9.8%
195	Adiposis Dolorosa	9.8%
196	Ecthyma	9.8%
197	Mastocytoma	9.8%
198	Lichen Planus	9.7%
199	Melanosis	9.7%
200	Chloasma	9.7%
201	Pityriasis Rosea	9.7%
202	Pityriasis Rubra Pilaris	9.7%
203	Vitiligo	9.7%
204	Lichen Nitidus	9.7%
205	Enterocolitis, Pseudomembranous	9.7%
206	pseudomembranous colitis	9.7%
207	Dysentery, Bacillary	9.7%
208	Hyperkeratosis, Epidermolytic	9.6%
209	Stomach Neoplasms	9.6%
210	Peutz-Jeghers Syndrome	9.5%
211	Duodenal Ulcer	9.3%
212	Peptic Ulcer Perforation	9.3%
213	Gastric ulcer	9.3%
214	Porphyrias, Hepatic	9.2%
215	Ichthyosis, X-Linked	8.9%
216	Sjogren-Larsson Syndrome	8.9%
217	Behcet Syndrome	8.7%
218	Afferent Loop Syndrome	8.6%
219	Celiac Disease	8.6%
220	Short Bowel Syndrome	8.6%
221	Sprue, Tropical	8.6%
222	Steatorrhea	8.6%
223	Sprue	8.6%
224	Hidradenitis Suppurativa	8.4%
225	Adenomatous Polyposis Coli	8.4%
226	Esophageal Neoplasms	8.2%
227	Esophageal and Gastric Varices	8.2%
228	Appendiceal Neoplasms	8.2%
229	Colonic Neoplasms	8.2%
230	Esophageal Stenosis	8.2%
231	Gastric Dilatation	8.2%
232	Gastric outlet obstruction	8.2%
233	Sigmoid Neoplasms	8.1%
234	Acanthosis Nigricans	8.1%
235	Alopecia Areata	8.1%
236	Lentigo	8.1%
237	Dermatomycoses	8%
238	Esophageal Atresia	8%
239	Mucocutaneous Lymph Node Syndrome	8%
240	Skin Diseases, Bacterial	8%
241	Drug Eruptions	7.9%
242	Lipodystrophy	7.9%
243	Livedo Reticularis	7.9%
244	Malignant Atrophic Papulosis	7.9%
245	Polyarteritis Nodosa	7.8%
246	Takayasu Arteritis	7.8%
247	Albinism	7.7%
248	Tinea Pedis	7.6%
249	Colitis, Ischemic	7.6%
250	Erythema Chronicum Migrans	7.6%
251	Intestinal Pseudo-Obstruction	7.5%
252	Irritable Bowel Syndrome	7.5%
253	Superior Mesenteric Artery Syndrome	7.5%
254	Neurogenic Bowel	7.5%
255	Digestive System Neoplasms	7.5%
256	Alopecia	7.5%
257	Sweating, Gustatory	7.5%
258	Androgenetic Alopecia	7.5%
259	Auriculotemporal Syndrome	7.5%
260	Lice Infestations	7.3%
261	Varicose Ulcer	7.3%
262	Breast Neoplasms, Male	7.3%
263	Triple Negative Breast Neoplasms	7.3%
264	Galactorrhea	7.3%
265	Mesenteric Panniculitis	7.1%
266	Panniculitis, Peritoneal	7.1%
267	Giardiasis	7.1%
268	Nail-Patella Syndrome	6.8%
269	Collagen Diseases	6.7%
270	Mixed Connective Tissue Disease	6.7%
271	Mucinoses	6.7%
272	Gastrointestinal Stromal Tumors	6.6%
273	Mycetoma	6.5%
274	Esophageal Perforation	6.5%
275	Barrett Esophagus	6.3%
276	Deglutition Disorders	6.3%
277	Variegate Porphyria	6.2%
278	Acute intermittent porphyria	6.2%
279	Porphyria Cutanea Tarda	6.2%
280	Lichen Planus, Oral	6.2%
281	Achlorhydria	6.2%
282	Gastric Antral Vascular Ectasia	6.2%
283	Peptic Ulcer Hemorrhage	6.1%
284	Gastroparesis	6.1%
285	Liver neoplasms	6.1%
286	CREST Syndrome	6.1%
287	Pancreatic Fistula	6.1%
288	Larva Migrans	6%
289	Leishmaniasis	6%
290	Molluscum Contagiosum	6%
291	Angioedema	5.9%
292	Onchocerciasis	5.9%
293	Chromoblastomycosis	5.9%
294	Dermatophytosis	5.9%
295	Sporotrichosis	5.9%
296	Tinea	5.9%
297	Tinea Versicolor	5.9%
298	Trichophytosis	5.9%
299	Hyalohyphomycosis	5.9%
300	Acute Generalized Exanthematous Pustulosis	5.8%
301	Lactose Intolerance	5.7%
302	Cartilage Diseases	5.3%
303	Rheumatism	5.3%
304	Chondromalacia	5.3%
305	Lupus Erythematosus, Systemic	5.1%
306	Overlap syndrome	5.1%
307	Peritoneal Neoplasms	5.1%
308	Warts	5%
309	Bile Duct Diseases	5%
310	Cholelithiasis	5%
311	Chylous Ascites	5%
312	Fatty Liver	5%
313	Hepatitis	5%
314	Portal Hypertension	5%
315	Liver Cirrhosis	5%
316	Pancreatic Insufficiency	5%
317	Pancreatitis	5%
318	Pneumoperitoneum	5%
319	Focal Nodular Hyperplasia	5%
320	Hepatic Insufficiency	5%
321	Steatohepatitis	5%
322	Melena	5%
323	Candidiasis, Chronic Mucocutaneous	4.9%
324	Cutaneous Candidiasis	4.9%
325	Hematemesis	4.9%
326	Erysipelas	4.9%
327	Serum Sickness	4.9%
328	Staphylococcal Skin Infections	4.9%
329	Leishmaniasis, Cutaneous	4.9%
330	Eczema Herpeticum	4.9%
331	Erythrasma	4.9%
332	Esophageal motility disorders	4.9%
333	Mallory-Weiss Syndrome	4.9%
334	Pyloric Stenosis	4.9%
335	Carcinoma, Lobular	4.9%
336	Arthritis, Psoriatic	4.8%
337	Fusariosis	4.8%
338	Pancreatic Neoplasm	4.4%
339	Scleromyxedema	4.4%
340	Cryptosporidiosis	4.4%
341	Giant Cell Arteritis	4.3%
342	Temporal Arteritis	4.3%
343	Hereditary Angioedema Type III	4.3%
344	Hereditary Angioedema Types I and II	4.3%
345	Cholecystolithiasis	4.1%
346	Bile Duct Neoplasms	4.1%
347	gallbladder neoplasm	4.1%
348	Angioedemas, Hereditary	4.1%
349	Epidermodysplasia Verruciformis	4.1%
350	Herpes Labialis	4.1%
351	Diabetic Foot	4.1%
352	Staphylococcal Scalded Skin Syndrome	4%
353	Dupuytren Contracture	4%
354	Liver Diseases, Parasitic	4%
355	Choledochal Cyst	3.9%
356	Biliary cirrhosis	3.9%
357	Hepatic Veno-Occlusive Disease	3.8%
358	Pancreatic Cyst	3.8%
359	Peliosis Hepatis	3.8%
360	Hepatopulmonary Syndrome	3.8%
361	Anus, Imperforate	3.8%
362	Hemoperitoneum	3.8%
363	Hepatomegaly	3.8%
364	Peritonitis	3.8%
365	Peritoneal Fibrosis	3.8%
366	Encapsulating Peritoneal Sclerosis	3.8%
367	Anorectal Malformations	3.8%
368	Biliary Fistula	3.7%
369	Gastric Fistula	3.7%
370	Hepatic Vein Thrombosis	3.7%
371	Liver Abscess	3.7%
372	Budd-Chiari Syndrome	3.7%
373	Blastomycosis	3.7%
374	Diverticulitis	3.6%
375	Dumping Syndrome	3.6%
376	HIV-Associated Lipodystrophy Syndrome	3.6%
377	carbuncle	3.6%
378	Condylomata Acuminata	3.5%
379	Furunculosis	3.5%
380	furuncle	3.5%
381	Impetigo	3.4%
382	Tietze's Syndrome	3.3%
383	Orbital Cellulitis	3.3%
384	Myxoid cyst	3.3%
385	Rhinoscleroma	3.3%
386	Cellulitis	3.3%
387	Myxedema	3.3%
388	Fatty Liver, Alcoholic	3.3%
389	Hepatitis, Alcoholic	3.3%
390	Liver Cirrhosis, Alcoholic	3.3%
391	Choledocholithiasis	3.3%
392	Menkes Kinky Hair Syndrome	3.2%
393	Esophageal Achalasia	3.2%
394	Chemical and Drug Induced Liver Injury	3.1%
395	Hepatorenal Syndrome	3%
396	Diverticulum	3%
397	Diverticulosis	3%
398	Cholangitis	2.7%
399	Cholecystitis	2.7%
400	Cholestasis	2.7%
401	Common Bile Duct Diseases	2.7%
402	Hepatitis, Chronic	2.7%
403	Liver Failure	2.7%
404	Pancreatitis, Chronic	2.7%
405	Non-alcoholic Fatty Liver Disease	2.7%
406	Chronic active hepatitis	2.7%
407	Hepatocellular Adenoma	2.7%
408	Osteochondritis	2.7%
409	Polymyalgia Rheumatica	2.7%
410	Osteogenesis Imperfecta	2.7%
411	Keloid	2.6%
412	Cystic Fibrosis	2.6%
413	Congenital Hyperinsulinism	2.5%
414	Noonan Syndrome	2.5%
415	Liver Abscess, Amebic	2.4%
416	Liver Neoplasms, Experimental	2.4%
417	Rheumatoid Arthritis	2.3%
418	Juvenile arthritis	2.3%
419	Marfan Syndrome	2.2%
420	Homocystinuria	2.2%
421	Lupus Nephritis	2.2%
422	Hepatitis, Animal	2.2%
423	Hepatitis, Viral, Human	2.2%
424	Liver Cirrhosis, Experimental	2.1%
425	Pancreatic Pseudocyst	2.1%
426	Pancreatitis, Alcoholic	2%
427	Rheumatoid Nodule	2%
428	Laryngomalacia	1.9%
429	Pectus carinatum	1.9%
430	Laryngopharyngeal Reflux	1.9%
431	Carcinoma, Pancreatic Ductal	1.8%
432	Fascioliasis	1.7%
433	Echinococcosis, Hepatic	1.7%
434	Chemical and Drug Induced Liver Injury, Chronic	1.7%
435	Reye Syndrome	1.6%
436	Felty Syndrome	1.6%
437	Bronchomalacia	1.6%
438	Tracheomalacia	1.6%
439	Cholestasis, Extrahepatic	1.6%
440	Biliary Dyskinesia	1.6%
441	Cholangitis, Sclerosing	1.6%
442	Liver Failure, Acute	1.6%
443	Acalculous Cholecystitis	1.6%
444	End Stage Liver Disease	1.6%
445	Rheumatoid Vasculitis	1.4%
446	Mucopolysaccharidosis III	1.4%
447	Nesidioblastosis	1.4%
448	Hepatitis B, Chronic	1.4%
449	Hepatitis C, Chronic	1.4%
450	Autoimmune hepatitis	1.2%
451	Sicca Syndrome	1.2%
452	Sjogren's Syndrome	1.2%
453	Zellweger Syndrome	1.2%
454	insulinoma	1.2%
455	Gastrinoma	1.2%
456	Glucagonoma	1.2%
457	Hepatolenticular Degeneration	1.1%
458	Massive Hepatic Necrosis	1.1%
459	Emphysematous Cholecystitis	1.1%
460	Sphincter of Oddi Dysfunction	1.1%
461	Vipoma	1.1%
462	Hepatitis, Viral, Animal	1%
463	Hepatitis E	1%
464	Lupus Vasculitis, Central Nervous System	1%
465	Hepatitis B	1%
466	Hepatitis C	1%
467	Hepatitis A	1%
468	Hepatic Encephalopathy	1%
469	Mucopolysaccharidosis II	1%
470	Rift Valley Fever	0.4%

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