MetaADEDB 2.0 @ LMMD
Levodopa
(WTDRDQBEARUVNC-LURJTMIESA-N)
Structure
SMILES
OC(=O)[C@H](Cc1ccc(c(c1)O)O)N
Type(s)
Approved
ATC code(s)
N04BA01; N04BA02; N04BA03
Molecular Formula:
C9H11NO4
Molecular Weight:
197.188
Log P:
0.7525
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
4
TPSA:
103.78
CAS Number(s):
59-92-7; 587-45-1
Synonym(s)
1.
Levodopa
2.
L-Dopa
3.
3-Hydroxy-L-tyrosine
4.
Dopaflex
5.
Dopar
6.
L-3,4-Dihydroxyphenylalanine
7.
Larodopa
8.
Levopa
9.
3 Hydroxy L tyrosine
10.
L 3,4 Dihydroxyphenylalanine
11.
L Dopa
External Link(s)
MeSHD007980
PubChem Compound6971033
6047
BindingDB50130192
60928
ChEBI15765
57504
CHEMBLCHEMBL1009
DrugBankDB01235
DrugCentral1567
IUPHAR/BPS Guide to PHARMACOLOGY3639
KEGGcpd:C00355
dr:D00059
Therapeutic Target DatabaseD08HVR
ZINC895199
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 30US FAERS
2Foreign body in respiratory tractFAERS: 20US FAERS
3ChokingFAERS: 12US FAERS
4Wrong technique in product usage processFAERS: 10US FAERS
5Device difficult to useFAERS: 9US FAERS
6DizzinessFAERS: 6
Canada Vigilance: 3
20461803CTD
Canada Vigilance
US FAERS
7RetchingFAERS: 6US FAERS
8Incorrect dose administeredFAERS: 5US FAERS
9NauseaFAERS: 5
Canada Vigilance: 7

View details

CTD
Canada Vigilance
US FAERS
10Oropharyngeal painFAERS: 5US FAERS
11Throat irritationFAERS: 5US FAERS
12Wrong technique in device usage processFAERS: 5US FAERS
13DysgeusiaFAERS: 4US FAERS
14Device use issueFAERS: 3US FAERS
15MalaiseFAERS: 3US FAERS
16Product use issueFAERS: 3US FAERS
17Therapeutic product effect incompleteFAERS: 3US FAERS
18AgitationFAERS: 2US FAERS
19AnxietyFAERS: 2OFFSIDES
US FAERS
20Burning sensationFAERS: 2US FAERS
21Choking sensationFAERS: 2US FAERS
22Euphoric moodFAERS: 2US FAERS
23FatigueFAERS: 220461803CTD
OFFSIDES
US FAERS
24HeadacheFAERS: 2
Canada Vigilance: 1
4921586
4924342
CTD
Canada Vigilance
US FAERS
25HypersensitivityFAERS: 2US FAERS
26Product use in unapproved indicationFAERS: 2US FAERS
27Productive CoughFAERS: 2US FAERS
28TremorFAERS: 2
Canada Vigilance: 1

View details

CTD
Canada Vigilance
US FAERS
29AphoniaFAERS: 1US FAERS
30AstheniaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
31AsthmaFAERS: 1US FAERS
32BradykinesiaFAERS: 1US FAERS
33BronchitisFAERS: 1OFFSIDES
US FAERS
34Cerebral atrophyFAERS: 1OFFSIDES
US FAERS
35Chest PainFAERS: 1US FAERS
36ConstipationFAERS: 1US FAERS
37CryingFAERS: 1OFFSIDES
US FAERS
38Device defectiveFAERS: 1US FAERS
39Device occlusionFAERS: 1US FAERS
40DiscomfortFAERS: 1US FAERS
41Drug ineffective for unapproved indicationFAERS: 1US FAERS
42DysphoniaFAERS: 1US FAERS
43DystoniaFAERS: 1

View details

CTD
OFFSIDES
US FAERS
44Feeling ColdFAERS: 1US FAERS
45Feeling abnormalFAERS: 1US FAERS
46Feeling jitteryFAERS: 1US FAERS
47Freezing phenomenonFAERS: 1US FAERS
48HypokinesiaFAERS: 1

View details

CTD
OFFSIDES
US FAERS
49HypotensionFAERS: 1
Canada Vigilance: 4

View details

CTD
Canada Vigilance
US FAERS
50Incorrect dose administered by deviceFAERS: 1US FAERS
51Intentional product misuseFAERS: 1US FAERS
52Joint swellingFAERS: 1US FAERS
53LeukoencephalopathyFAERS: 1OFFSIDES
US FAERS
54Limb injuryFAERS: 1US FAERS
55Lip swellingFAERS: 1US FAERS
56Mental impairmentFAERS: 1OFFSIDES
US FAERS
57Muscle RigidityFAERS: 1

View details

CTD
US FAERS
58NasopharyngitisFAERS: 1US FAERS
59NeuralgiaFAERS: 1US FAERS
60OsteomalaciaFAERS: 1US FAERS
61PallorFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
62Peripheral swellingFAERS: 1US FAERS
63Prescribed underdoseFAERS: 1US FAERS
64Product communication issueFAERS: 1US FAERS
65Product outer packaging issueFAERS: 1US FAERS
66Product packaging quantity issueFAERS: 1US FAERS
67Product physical issueFAERS: 1US FAERS
68Product prescribing issueFAERS: 1US FAERS
69Product size issueFAERS: 1US FAERS
70Product taste abnormalFAERS: 1US FAERS
71Product use complaintFAERS: 1US FAERS
72Pulmonary congestionFAERS: 1US FAERS
73Secretion dischargeFAERS: 1US FAERS
74SinusitisFAERS: 1US FAERS
75Therapeutic product effect decreasedFAERS: 1US FAERS
76Therapeutic response unexpectedFAERS: 1US FAERS
77Therapy cessationFAERS: 1US FAERS
78Urinary tract infectionFAERS: 1US FAERS
79VomitingFAERS: 1

View details

CTD
US FAERS
80WheezingFAERS: 1US FAERS
81Abdominal PainCanada Vigilance: 1Canada Vigilance
OFFSIDES
82AbuseOFFSIDES
83AdenomaOFFSIDES
84Adverse eventOFFSIDES
85AgeusiaOFFSIDES
86AgoraphobiaOFFSIDES
87AgraphiaOFFSIDES
88Akathisia, Drug-Induced3495642CTD
89AkinesiaOFFSIDES
90AlopeciaOFFSIDES
91Amblyopia12618298CTD
OFFSIDES
92AmnesiaOFFSIDES
93AmphetaminesOFFSIDES
94Amyotrophic Lateral Sclerosis4743883
14962622
CTD
95Anal candidiasisOFFSIDES
96Anemia, Hemolytic466061CTD
97Anemia900589
7091780
CTD
98AnhedoniaOFFSIDES
99AnosmiaOFFSIDES
100Aortic valve sclerosisOFFSIDES
101AphasiaCanada Vigilance: 1Canada Vigilance
102Arthralgia20461803CTD
103ArthritisOFFSIDES
104AthetosisOFFSIDES
105AuraOFFSIDES
106Back PainCanada Vigilance: 120461803CTD
Canada Vigilance
107Basal Ganglia Diseases15037850CTD
108Basal ganglion degenerationOFFSIDES
109BedriddenOFFSIDES
110Bipolar Disorder4066999CTD
111Blepharospasm9120447CTD
OFFSIDES
112Blood blisterOFFSIDES
113Blood creatine phosphokinase MB increasedOFFSIDES
114Blood electrolytes abnormalOFFSIDES
115Blood glucose decreasedOFFSIDES
116Blood pH increasedOFFSIDES
117Blood parathyroid hormone increasedOFFSIDES
118Blood sodium increasedOFFSIDES
119Bone painOFFSIDES
120BradycardiaCanada Vigilance: 11255483CTD
Canada Vigilance
121Brain Diseases

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CTD
122Brain Injuries15342103CTD
123Brain scan abnormalOFFSIDES
124Brain stem syndromeOFFSIDES
125BruxismOFFSIDES
126Camptocormia14638981CTD
127Cardiac ArrestCanada Vigilance: 1Canada Vigilance
128Cardiac valve sclerosisOFFSIDES
129Cardioactive drug level increasedOFFSIDES
130Carnitine decreasedOFFSIDES
131Catalepsy

View details

CTD
132Catatonia4397415
11980384
CTD
133Cerebral ventricle dilatationOFFSIDES
134Chest discomfortCanada Vigilance: 2Canada Vigilance
135ChoreaCanada Vigilance: 1

View details

CTD
Canada Vigilance
136ChromatopsiaCanada Vigilance: 1Canada Vigilance
137Chronic left ventricular failureOFFSIDES
138Circumstance or information capable of leading to medication errorOFFSIDES
139ClumsinessCanada Vigilance: 1Canada Vigilance
140Cocaine-Related Disorders18164144
20545388
CTD
141Cognition Disorders4398328
7481406
CTD
142Cogwheel RigidityOFFSIDES
143Colon adenomaOFFSIDES
144Completed SuicideOFFSIDES
145Compulsive shoppingOFFSIDES
146Confusion

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CTD
147Congenital tricuspid valve incompetenceOFFSIDES
148Cyclothymic DisorderOFFSIDES
149DehydrationCanada Vigilance: 1Canada Vigilance
150Delirium290736CTD
151Delusional disorder, persecutory typeOFFSIDES
152DemyelinationOFFSIDES
153Dental cariesOFFSIDES
154Depressed moodOFFSIDES
155Disorders of Excessive Somnolence

View details

CTD
156Disseminated Intravascular Coagulation1295627
2044308
CTD
157Dopamine dysregulation syndromeOFFSIDES
158DrowsinessOFFSIDES
159Drug addictOFFSIDES
160Drug chemical incompatibilityOFFSIDES
161Drug resistanceOFFSIDES
162Drug specific antibody absentOFFSIDES
163Dyskinesia, Drug-Induced

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16772814
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16908747
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16930362
16944114
16971529
17028572
17094088
17116309
17143205
17150360
17188499
17192438
17196621
17219962
17221016
17230470
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17329435
17335811
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17388990
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21145888
21161716
21183918
21232546
21371994
21591752
21737418
21984936
23535177
23952588
24126708
CTD
164EcholaliaOFFSIDES
165Elevated moodOFFSIDES
166Endocardial diseaseOFFSIDES
167EnterocolitisOFFSIDES
168EosinophiliaCanada Vigilance: 1Canada Vigilance
169Eosinophilic PneumoniaOFFSIDES
170EpilepsyOFFSIDES
171Erectile dysfunction9921882CTD
OFFSIDES
172Exaggerated startle responseOFFSIDES
173ExcoriationOFFSIDES
174Failure of implantOFFSIDES
175FlatulenceOFFSIDES
176Fluid overloadOFFSIDES
177Flushing14509040CTD
178Food cravingOFFSIDES
179FormicationOFFSIDES
180Gait Disorders, Neurologic2511378
11181848
CTD
181GamblingOFFSIDES
182Gastrointestinal Diseases1549199
4102620
CTD
183General physical health deteriorationOFFSIDES
184GlossoptosisOFFSIDES
185HaemoconcentrationOFFSIDES
186Hallucinations

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CTD
187Heart failure10367596CTD
188Hepatolenticular Degeneration4192136CTD
189High frequency ablationOFFSIDES
190Hyperalgesia17141847CTD
191Hyperhomocysteinemia16275827
16787708
CTD
192HyperreflexiaOFFSIDES
193Hypertensive heart diseaseOFFSIDES
194Hypokalemia851038CTD
195HypomaniaOFFSIDES
196HypophagiaOFFSIDES
197Hypotension, Orthostatic

View details

CTD
198Iliotibial Band SyndromeOFFSIDES
199Impaired driving abilityOFFSIDES
200Incorrect drug administration rateOFFSIDES
201Infusion site mobility decreasedOFFSIDES
202Intention tremorOFFSIDES
203Intentional self-injuryOFFSIDES
204Intervertebral disc disorderOFFSIDES
205Jealous delusionOFFSIDES
206Joint injuryOFFSIDES
207Joint stiffnessOFFSIDES
208KleptomaniaOFFSIDES
209LaryngospasmOFFSIDES
210Left atrial dilatationOFFSIDES
211Leukopenia neonatalOFFSIDES
212Lip erosionOFFSIDES
213Lupus-like syndromeOFFSIDES
214Malignant HypertensionOFFSIDES
215Manganese Poisoning123156CTD
216Memory Disorders14598078CTD
217Mental disorders

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CTD
218MetatarsalgiaOFFSIDES
219Mitral valve sclerosisOFFSIDES
220Monoclonal immunoglobulin presentOFFSIDES
221Motor retardationOFFSIDES
222Movement Disorders

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CTD
223Multiple Sclerosis14962622CTD
224Multiple System Atrophy1469394
9087971
CTD
225Muscle Spasticity72141CTD
226Musculoskeletal chest painOFFSIDES
227Musculoskeletal stiffnessCanada Vigilance: 1Canada Vigilance
228MyelodysplasiaOFFSIDES
229Myeloid maturation arrestOFFSIDES
230Myoclonus

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CTD
231Necrosis9633686CTD
232Neoplasms759779CTD
233NervousnessCanada Vigilance: 1Canada Vigilance
234Neurodegeneration with brain iron accumulation (NBIA)20629144CTD
235Neuroleptic Malignant Syndrome1295627
2044308
CTD
OFFSIDES
236Neurologic Manifestations23062100CTD
237Neurotoxicity Syndromes20643751CTD
238Nocturnal Myoclonus Syndrome9295178CTD
239Nodal osteoarthritisOFFSIDES
240Non-cardiac chest painOFFSIDES
241Nuchal RigidityOFFSIDES
242NystagmusOFFSIDES
243Ocular Motility Disorders9686783
11835460
17880568
CTD
244Oral fungal infectionOFFSIDES
245Oral pruritusCanada Vigilance: 1Canada Vigilance
246OsteochondrosisOFFSIDES
247OverdoseOFFSIDES
248Pain

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CTD
249Panic DisorderOFFSIDES
250Paranasal sinus hypersecretionOFFSIDES
251ParanoiaOFFSIDES
252Paraplegia961498CTD
253Parkinson Disease

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12112201
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14748772
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14962622
15111244
15190235
15382192
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15592807
15851743
15869945
15994112
16029215
16302846
16353177
16476674
16476808
16564615
16682679
16925499
16941457
17196621
17221016
17388990
17534955
18157704
18181204
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18523852
18698234
18978500
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19786063
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20339282
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20592420
20686159
20880751
20945430
21108621
21815648
23952588
23959161
24099722
24126708
CTD
254Parkinsonian Disorders

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CTD
255Performance status decreasedOFFSIDES
256Peripheral Nervous System Diseases24099722CTD
257Persistent Vegetative State10654305CTD
258Personality Disorders1168580CTD
259Poor quality sleepOFFSIDES
260PruritusCanada Vigilance: 1Canada Vigilance
261Psychomotor Disorders4102620CTD
262Psychomotor skills impairedOFFSIDES
263Psychoses, Substance-Induced

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CTD
264Psychotic Disorders756020
10751276
CTD
265Pulmonary HypertensionOFFSIDES
266Reflux gastritisOFFSIDES
267Reflux laryngitisOFFSIDES
268Respiration Disorders12112201CTD
269Respiratory Sounds6622345CTD
270Restless Legs Syndrome1679281
9295178
CTD
271Restrictive cardiomyopathyOFFSIDES
272RetrocollisOFFSIDES
273Right Ventricular HypertrophyOFFSIDES
274Schizophrenia Spectrum and Other Psychotic Disorders18044770CTD
275SclerodermaOFFSIDES
276Seizures

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CTD
277Self Mutilation1418306CTD
278Serotonin Syndrome3711372CTD
279Sexual activity increasedOFFSIDES
280Shy-Drager Syndrome963636CTD
281Sinus headacheOFFSIDES
282Sinus perforationOFFSIDES
283Sinus polypOFFSIDES
284Sleep Bruxism15749418CTD
285Sleep Initiation and Maintenance Disorders20461803CTD
286Sleep Wake Disorders3243678
7139632
11307043
CTD
287Somatosensory Disorders11606670CTD
288SomnolenceCanada Vigilance: 1Canada Vigilance
289Speech Disorders2746281
11391759
CTD
290SpondylolysisOFFSIDES
291Stem cell transplantOFFSIDES
292Stereotypic Movement Disorder10495047CTD
293StridorOFFSIDES
294StuporCanada Vigilance: 2Canada Vigilance
295Substance Withdrawal Syndrome

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CTD
296Substance-Related Disorders2973725CTD
297Sudden deathOFFSIDES
298SwellingCanada Vigilance: 1Canada Vigilance
299Syncope1115660
1254882
9120531
CTD
300Synovial CystOFFSIDES
301TendinitisOFFSIDES
302ThirstCanada Vigilance: 1Canada Vigilance
303ThrombocytopeniaCanada Vigilance: 1Canada Vigilance
304Tooth repairOFFSIDES
305Torticollis1679895CTD
306Transvestism12151912CTD
307Troponin TOFFSIDES
308Upper respiratory tract inflammationOFFSIDES
309Urinary Bladder Diseases15382192CTD
310Urinary Retention946861CTD
311Urination Disorders15382192CTD
312Vascular Diseases10408491CTD
313Venous InsufficiencyOFFSIDES
314Vision Disorders3674801CTD
315Weight decreasedCanada Vigilance: 1Canada Vigilance
316Wrong drug administeredOFFSIDES
317muscle injuryOFFSIDES
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