MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Intussusception

(UMLS:C0021933)

Definition:: A form of intestinal obstruction caused by the PROLAPSE of a part of the intestine into the adjoining intestinal lumen. There are four types: colic, involving segments of the LARGE INTESTINE; enteric, involving only the SMALL INTESTINE; ileocecal, in which the ILEOCECAL VALVE prolapses into the CECUM, drawing the ILEUM along with it; and ileocolic, in which the ileum prolapses through the ileocecal valve into the COLON.
UMLS ID:: C0021933
MeSH ID:: D007443

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.531.577

Synonym(s)

Intussusception

INTUSSUSCEPTION

ISN - Intussusception

Intestinal intussusception

Intestines--Intussusception

Introsusception

Intussusception of bowel

Intussusception of intestine

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	carbidopa, levodopa drug combination	FAERS: 9 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Dimethyl Fumarate	FAERS: 6		US FAERS
3	Methotrexate	FAERS: 6		US FAERS
4	Methylphenidate	FAERS: 6		OFFSIDES US FAERS
5	Isotretinoin	FAERS: 5		US FAERS
6	Methadone	FAERS: 5		US FAERS
7	Octreotide	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Ondansetron	FAERS: 4		US FAERS
9	Tacrolimus	FAERS: 4		OFFSIDES US FAERS
10	Cefdinir	FAERS: 3		OFFSIDES US FAERS
11	Imatinib Mesylate	FAERS: 3		US FAERS
12	Indomethacin	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
13	ceritinib	FAERS: 3		US FAERS
14	Cetirizine	FAERS: 2		US FAERS
15	Cisapride	FAERS: 2		US FAERS
16	Cytarabine	FAERS: 2		US FAERS
17	Dabigatran	FAERS: 2		US FAERS
18	Glatiramer Acetate	FAERS: 2		US FAERS
19	Octreotide	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
20	Olmesartan Medoxomil	FAERS: 2		US FAERS
21	Paroxetine	FAERS: 2		US FAERS
22	Vemurafenib	FAERS: 2		US FAERS
23	Vincristine	FAERS: 2		US FAERS
24	acetaminophen, codeine drug combination	FAERS: 2		US FAERS
25	methylnaltrexone	FAERS: 2		US FAERS
26	treprostinil	FAERS: 2		US FAERS
27	2-[(E)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid;(2S)-2,6-diaminohexanoic acid	FAERS: 1		US FAERS
28	Acetaminophen	FAERS: 1		US FAERS
29	Albuterol	FAERS: 1		US FAERS
30	Amoxicillin-Potassium Clavulanate Combination	FAERS: 1		US FAERS
31	Azathioprine	FAERS: 1		US FAERS
32	Bosentan	FAERS: 1		US FAERS
33	Budesonide	FAERS: 1		US FAERS
34	Buprenorphine	FAERS: 1		US FAERS
35	Carbamazepine	FAERS: 1		US FAERS
36	Ceftriaxone	FAERS: 1		US FAERS
37	Clozapine	FAERS: 1		US FAERS
38	Donepezil	FAERS: 1		US FAERS
39	Erlotinib Hydrochloride	FAERS: 1		US FAERS
40	Flutamide	FAERS: 1		US FAERS
41	Ibuprofen	FAERS: 1		US FAERS
42	Lenalidomide	FAERS: 1		US FAERS
43	Lubiprostone	FAERS: 1		US FAERS
44	NuvaRing	FAERS: 1		US FAERS
45	Omeprazole	FAERS: 1		US FAERS
46	Prednisolone	FAERS: 1		US FAERS
47	Propylthiouracil	FAERS: 1		US FAERS
48	Risperidone	FAERS: 1		US FAERS
49	Rivaroxaban	FAERS: 1		US FAERS
50	Sunitinib	FAERS: 1		OFFSIDES US FAERS
51	Topiramate	FAERS: 1		US FAERS
52	Voriconazole	FAERS: 1		US FAERS
53	Warfarin	FAERS: 1		US FAERS
54	dolutegravir	FAERS: 1		US FAERS
55	edoxaban	FAERS: 1		US FAERS
56	eltrombopag	FAERS: 1		US FAERS
57	fosphenytoin	FAERS: 1		US FAERS
58	midostaurin	FAERS: 1		US FAERS
59	naloxegol	FAERS: 1		US FAERS
60	tofacitinib	FAERS: 1		US FAERS
61	Acarbose			SIDER
62	Allopurinol			OFFSIDES
63	Amphetamine			OFFSIDES
64	Ampicillin			OFFSIDES
65	Ascorbic Acid			OFFSIDES
66	Cocaine		16570192	CTD
67	Daunorubicin			OFFSIDES
68	Dobutamine			OFFSIDES
69	Docusate sodium			OFFSIDES
70	Epoprostenol			OFFSIDES
71	Fenofibrate			OFFSIDES
72	Fludrocortisone			OFFSIDES
73	Fluvastatin			OFFSIDES
74	Letrozole			OFFSIDES
75	Melatonin			OFFSIDES
76	Mometasone Furoate			OFFSIDES
77	Mycophenolic Acid			OFFSIDES
78	Sunitinib			OFFSIDES
79	Tobramycin			OFFSIDES
80	Tretinoin			OFFSIDES
81	Ursodeoxycholic Acid			OFFSIDES
82	Zidovudine			OFFSIDES
83	alfacalcidol			OFFSIDES
84	alosetron			SIDER
85	calcium lactate			OFFSIDES
86	itopride			OFFSIDES
87	miglitol			SIDER
88	pantethine			OFFSIDES
89	pimecrolimus			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Fecal Impaction	48.4%
2	Ileus	48.4%
3	Meconium ileus	48.4%
4	Duodenal Obstruction	47.3%
5	Intestinal Pseudo-Obstruction	36%
6	Cecal Diseases	34.4%
7	Colonic Diseases	34.4%
8	Ileal Diseases	34.4%
9	Intestinal Perforation	34.4%
10	Jejunal Diseases	34.4%
11	Pneumatosis Cystoides Intestinalis	34.4%
12	Rectal Diseases	34.4%
13	Cronkhite-Canada Syndrome	34.4%
14	Intestinal Polyposis	34.4%
15	Dysentery	33%
16	Enteritis	33%
17	Enterocolitis	33%
18	Inflammatory Bowel Diseases	33%
19	Afferent Loop Syndrome	32.6%
20	Colonic Pseudo-Obstruction	31%
21	Duodenitis	27.4%
22	Ileitis	27.4%
23	Erosive Duodenitis	27.4%
24	Esophageal Diseases	25.4%
25	Gastroenteritis	25.4%
26	Stomach Diseases	25.4%
27	Colitis	25%
28	Duodenogastric Reflux	25%
29	Peptic Ulcer	25%
30	Proctitis	25%
31	Intestinal Diseases, Parasitic	24.7%
32	Zollinger-Ellison syndrome	24%
33	Proctocolitis	23.2%
34	Colorectal Neoplasms	23%
35	Colonic Diseases, Functional	22.6%
36	Fecal Incontinence	22.6%
37	Megacolon	22.6%
38	Mesenteric vascular insufficiency	22.2%
39	Intestinal Atresia	21.8%
40	Mesenteric Vascular Occlusion	21.8%
41	Intestinal Neoplasms	21.7%
42	Intestinal Fistula	21.7%
43	Enterocutaneous Fistula	21.7%
44	Crohn Disease	21.5%
45	Enterocolitis, Neutropenic	21.5%
46	Necrotizing Enterocolitis	21.5%
47	Pouchitis	20.3%
48	Rectal Fistula	20.1%
49	Anal Fistula	20.1%
50	Esophagitis	19.8%
51	Gastritis	19.8%
52	Cecal Neoplasms	19.3%
53	Duodenal Neoplasms	19.3%
54	Appendicitis	18.9%
55	Duodenal Ulcer	17.6%
56	Peptic Ulcer Perforation	17.6%
57	Gastric ulcer	17.6%
58	Gastrointestinal Neoplasms	17.1%
59	Gastrointestinal Hemorrhage	16.9%
60	Anal Fissure	16.8%
61	Irritable Bowel Syndrome	16.8%
62	Superior Mesenteric Artery Syndrome	16.8%
63	Neurogenic Bowel	16.8%
64	Anal Ulcer	16.8%
65	Tuberculosis, Gastrointestinal	16.5%
66	Biliary Tract Diseases	16.4%
67	Liver diseases	16.4%
68	Pancreatic Diseases	16.4%
69	Enterocolitis, Pseudomembranous	16.1%
70	pseudomembranous colitis	16.1%
71	Dysentery, Bacillary	16.1%
72	Hemorrhoids	15.6%
73	Celiac Disease	15.2%
74	Short Bowel Syndrome	15.2%
75	Sprue, Tropical	15.2%
76	Steatorrhea	15.2%
77	Rectocele	15.2%
78	Sprue	15.2%
79	Rectal Prolapse	15.1%
80	Anus Neoplasms	14.9%
81	Sigmoid Neoplasms	14.9%
82	Esophageal Stenosis	14.8%
83	Gastric Dilatation	14.8%
84	Gastric outlet obstruction	14.8%
85	Appendiceal Neoplasms	14.3%
86	Colonic Neoplasms	14.3%
87	Rectal Neoplasms	14.3%
88	Stomach Neoplasms	13.8%
89	Colitis, Ischemic	13.6%
90	Adenomatous Polyposis Coli	13.3%
91	Esophageal and Gastric Varices	13.2%
92	Giardiasis	11.9%
93	Esophageal Atresia	11.8%
94	Esophageal Neoplasms	11.5%
95	Pruritus Ani	11.4%
96	Digestive System Neoplasms	10.8%
97	Esophageal Perforation	10.6%
98	Barrett Esophagus	10.1%
99	Deglutition Disorders	10.1%
100	Achlorhydria	9.9%
101	Gastric Antral Vascular Ectasia	9.9%
102	Gastrointestinal Stromal Tumors	9.8%
103	Peptic Ulcer Hemorrhage	9.8%
104	Gastroparesis	9.8%
105	Esophageal motility disorders	9.7%
106	Mallory-Weiss Syndrome	9.7%
107	Pyloric Stenosis	9.7%
108	Peutz-Jeghers Syndrome	9.2%
109	Lactose Intolerance	9.1%
110	Liver neoplasms	8.5%
111	Bile Duct Diseases	8.5%
112	Cholelithiasis	8.5%
113	Chylous Ascites	8.5%
114	Fatty Liver	8.5%
115	Hepatitis	8.5%
116	Portal Hypertension	8.5%
117	Liver Cirrhosis	8.5%
118	Pancreatic Fistula	8.5%
119	Pancreatic Insufficiency	8.5%
120	Pancreatitis	8.5%
121	Pneumoperitoneum	8.5%
122	Focal Nodular Hyperplasia	8.5%
123	Hepatic Insufficiency	8.5%
124	Steatohepatitis	8.5%
125	Melena	7.5%
126	Hematemesis	7.3%
127	Esophageal Achalasia	7.2%
128	Peritoneal Neoplasms	6.8%
129	Cryptosporidiosis	6.7%
130	Cholecystolithiasis	6.6%
131	Diverticulitis	6.5%
132	Dumping Syndrome	6.5%
133	Biliary cirrhosis	6.1%
134	Liver Diseases, Parasitic	6%
135	Bile Duct Neoplasms	5.9%
136	gallbladder neoplasm	5.9%
137	Hepatic Veno-Occlusive Disease	5.7%
138	Pancreatic Cyst	5.7%
139	Peliosis Hepatis	5.7%
140	Hepatopulmonary Syndrome	5.7%
141	Pancreatic Neoplasm	5.7%
142	Anus, Imperforate	5.6%
143	Hemoperitoneum	5.6%
144	Hepatomegaly	5.6%
145	Mesenteric Panniculitis	5.6%
146	Panniculitis, Peritoneal	5.6%
147	Peritonitis	5.6%
148	Peritoneal Fibrosis	5.6%
149	Encapsulating Peritoneal Sclerosis	5.6%
150	Anorectal Malformations	5.6%
151	Biliary Fistula	5.6%
152	Gastric Fistula	5.6%
153	Hepatic Vein Thrombosis	5.5%
154	Liver Abscess	5.5%
155	Budd-Chiari Syndrome	5.5%
156	Choledochal Cyst	5.4%
157	Choledocholithiasis	5.4%
158	Diverticulum	5%
159	Diverticulosis	5%
160	Cholangitis	4.9%
161	Cholecystitis	4.9%
162	Cholestasis	4.9%
163	Common Bile Duct Diseases	4.9%
164	Hepatitis, Chronic	4.9%
165	Liver Failure	4.9%
166	Pancreatitis, Chronic	4.9%
167	Non-alcoholic Fatty Liver Disease	4.9%
168	Chronic active hepatitis	4.9%
169	Fatty Liver, Alcoholic	4.9%
170	Hepatitis, Alcoholic	4.9%
171	Liver Cirrhosis, Alcoholic	4.9%
172	Chemical and Drug Induced Liver Injury	4.3%
173	Hepatorenal Syndrome	4.2%
174	Laryngopharyngeal Reflux	4.1%
175	Hepatocellular Adenoma	3.9%
176	Hepatitis, Animal	3.5%
177	Hepatitis, Viral, Human	3.5%
178	Cystic Fibrosis	3.5%
179	Porphyrias, Hepatic	3.4%
180	Congenital Hyperinsulinism	3.4%
181	Liver Abscess, Amebic	3.3%
182	Liver Neoplasms, Experimental	3.3%
183	Liver Cirrhosis, Experimental	3.3%
184	Pancreatic Pseudocyst	3.3%
185	Pancreatitis, Alcoholic	3.3%
186	Cholestasis, Extrahepatic	3.2%
187	Biliary Dyskinesia	3.2%
188	Cholangitis, Sclerosing	3.2%
189	Liver Failure, Acute	3.2%
190	Acalculous Cholecystitis	3.2%
191	End Stage Liver Disease	3.2%
192	Fascioliasis	2.5%
193	Echinococcosis, Hepatic	2.5%
194	Chemical and Drug Induced Liver Injury, Chronic	2.5%
195	Reye Syndrome	2.5%
196	Carcinoma, Pancreatic Ductal	2.4%
197	Massive Hepatic Necrosis	2.4%
198	Emphysematous Cholecystitis	2.4%
199	Sphincter of Oddi Dysfunction	2.4%
200	Hepatitis B, Chronic	2.3%
201	Hepatitis C, Chronic	2.3%
202	Autoimmune hepatitis	2.2%
203	CREST Syndrome	2.1%
204	Nesidioblastosis	1.9%
205	Variegate Porphyria	1.9%
206	Acute intermittent porphyria	1.9%
207	Porphyria Cutanea Tarda	1.9%
208	insulinoma	1.8%
209	Gastrinoma	1.8%
210	Glucagonoma	1.8%
211	Hepatitis, Viral, Animal	1.8%
212	Hepatitis E	1.7%
213	Hepatitis B	1.7%
214	Hepatitis C	1.7%
215	Hepatitis A	1.7%
216	Hepatic Encephalopathy	1.6%
217	Vipoma	1.6%
218	Zellweger Syndrome	1.5%
219	Hepatolenticular Degeneration	1.4%
220	Rift Valley Fever	0.7%

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