MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hepatitis A

(UMLS:C0019159)

Definition:: INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.
UMLS ID:: C0019159
MeSH ID:: D006506

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.440.420|C02.782.687.359.500

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.380.705.422

Synonym(s)

Hepatitis A

Acute Hepatitis A

HAV

HEPATITIS A

HEPATITIS INFECTIOUS

HEPATITIS, INFECTIOUS

Hep A, NOS

Hepatitis A Infection

Hepatitis;infectious

10.

IH - Infectious hepatitis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 13 Canada Vigilance: 1		Canada Vigilance US FAERS
2	rofecoxib	FAERS: 10		US FAERS
3	Imatinib Mesylate	FAERS: 6		US FAERS
4	teriflunomide	FAERS: 5		US FAERS
5	Duloxetine Hydrochloride	FAERS: 4		US FAERS
6	Fingolimod Hydrochloride	FAERS: 4		US FAERS
7	Methylphenidate	FAERS: 4		US FAERS
8	Dimethyl Fumarate	FAERS: 3		US FAERS
9	Methotrexate	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
10	Valsartan	FAERS: 3		US FAERS
11	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
12	Atomoxetine Hydrochloride	FAERS: 2		US FAERS
13	Atorvastatin	FAERS: 2		US FAERS
14	Insulin Glargine	FAERS: 2		US FAERS
15	Isotretinoin	FAERS: 2		US FAERS
16	Loratadine	FAERS: 2		US FAERS
17	Methylphenidate	FAERS: 2		US FAERS
18	Moxifloxacin	FAERS: 2		US FAERS
19	Norgestrel	FAERS: 2		US FAERS
20	Ofloxacin	FAERS: 2		US FAERS
21	Raltegravir Potassium	FAERS: 2		US FAERS
22	Sildenafil Citrate	FAERS: 2		US FAERS
23	Tamoxifen	FAERS: 2		US FAERS
24	Triumeq	FAERS: 2		US FAERS
25	Valproic Acid	FAERS: 2		US FAERS
26	Venlafaxine Hydrochloride	FAERS: 2		US FAERS
27	ambrisentan	FAERS: 2		US FAERS
28	nefazodone	FAERS: 2		US FAERS
29	Albendazole	FAERS: 1		US FAERS
30	Amlodipine	FAERS: 1		US FAERS
31	Arthrotec	FAERS: 1		US FAERS
32	Azithromycin	FAERS: 1		US FAERS
33	Bosentan	FAERS: 1		US FAERS
34	Canagliflozin	FAERS: 1		US FAERS
35	Carbamazepine	FAERS: 1		US FAERS
36	Clindamycin	FAERS: 1		US FAERS
37	Clozapine	FAERS: 1		US FAERS
38	Dantrolene	FAERS: 1		OFFSIDES US FAERS
39	Desvenlafaxine Succinate	FAERS: 1		US FAERS
40	Finasteride	FAERS: 1		US FAERS
41	Fulvestrant	FAERS: 1		US FAERS
42	Glatiramer Acetate	FAERS: 1		US FAERS
43	Ibuprofen	FAERS: 1		US FAERS
44	Indinavir	FAERS: 1		US FAERS
45	Iohexol	FAERS: 1		US FAERS
46	Isoniazid	FAERS: 1		US FAERS
47	Mesalamine	FAERS: 1		US FAERS
48	Methylprednisolone	FAERS: 1		US FAERS
49	Nebivolol	FAERS: 1		US FAERS
50	Oseltamivir	FAERS: 1		US FAERS
51	PCI 32765	FAERS: 1		US FAERS
52	Phenobarbital	FAERS: 1		OFFSIDES US FAERS
53	Pregabalin	FAERS: 1		US FAERS
54	QVA149	FAERS: 1		US FAERS
55	Rabeprazole	FAERS: 1		US FAERS
56	Raloxifene Hydrochloride	FAERS: 1		US FAERS
57	Rivaroxaban	FAERS: 1		US FAERS
58	Sitagliptin Phosphate	FAERS: 1		US FAERS
59	Tenofovir	FAERS: 1		US FAERS
60	Tenofovir	FAERS: 1		OFFSIDES US FAERS
61	Terbinafine	FAERS: 1		OFFSIDES US FAERS
62	Teriparatide	FAERS: 1		US FAERS
63	Tiotropium Bromide	FAERS: 1		US FAERS
64	Tramadol	FAERS: 1		US FAERS
65	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
66	Valproic Acid	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
67	acetaminophen, aspirin, caffeine drug combination	FAERS: 1		US FAERS
68	apixaban	FAERS: 1		US FAERS
69	apremilast	FAERS: 1		US FAERS
70	dolutegravir	FAERS: 1		US FAERS
71	eluxadoline	FAERS: 1		US FAERS
72	mirabegron	FAERS: 1		US FAERS
73	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
74	tofacitinib	FAERS: 1		US FAERS
75	Acebutolol			OFFSIDES
76	Amantadine		2167349	CTD
77	Betaxolol			OFFSIDES
78	Carbimazole			OFFSIDES
79	Chloroquine	Canada Vigilance: 1		Canada Vigilance
80	Chlorpromazine			SIDER
81	Ciprofloxacin			OFFSIDES
82	Cisapride			OFFSIDES
83	Clonidine			OFFSIDES
84	Clopidogrel			SIDER
85	Colchicine			OFFSIDES
86	Dapsone			OFFSIDES
87	Daunorubicin			OFFSIDES
88	Deferoxamine			OFFSIDES
89	Desflurane			OFFSIDES
90	Didanosine			OFFSIDES
91	Diphenhydramine			OFFSIDES
92	Disulfiram			OFFSIDES
93	Doxepin			OFFSIDES
94	Erythromycin Estolate	Canada Vigilance: 1		Canada Vigilance
95	Flurbiprofen			OFFSIDES
96	Ganciclovir			OFFSIDES
97	Glycyrrhizic Acid		2167349	CTD
98	Halothane	Canada Vigilance: 1		Canada Vigilance
99	Hydroxyurea			OFFSIDES
100	Ketoconazole			OFFSIDES
101	Lenalidomide			OFFSIDES
102	Memantine			OFFSIDES
103	Nitrofurantoin			OFFSIDES
104	Olopatadine Hydrochloride			OFFSIDES
105	Oseltamivir			OFFSIDES
106	Pancuronium			OFFSIDES
107	Panipenem-betamipron			OFFSIDES
108	Penicillin V			OFFSIDES
109	Perphenazine			SIDER
110	Piperacillin, Tazobactam Drug Combination			OFFSIDES
111	Prazepam			OFFSIDES
112	Pyridostigmine Bromide			OFFSIDES
113	Ribavirin		2167349	CTD
114	Rivastigmine			OFFSIDES
115	Tamoxifen			OFFSIDES
116	Thiopental			OFFSIDES
117	Tilidine			OFFSIDES
118	Tretinoin			OFFSIDES
119	aliskiren			OFFSIDES
120	candesartan			SIDER
121	efavirenz			OFFSIDES
122	fludarabine phosphate			OFFSIDES
123	flupirtine			OFFSIDES
124	hydrocodone tartrate, ibuprofen drug combination			OFFSIDES
125	nefazodone			OFFSIDES
126	pyrazofurin		2167349	CTD
127	ramosetron			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hepatitis E	46.3%
2	Hepatitis C	41.3%
3	Hepatitis B	38%
4	Herpangina	35.3%
5	Hepatitis C, Chronic	32.1%
6	Hepatitis B, Chronic	30.2%
7	Coxsackievirus Infections	28.9%
8	Rift Valley Fever	24.9%
9	Cardiovirus Infections	22.5%
10	Pleurodynia, Epidemic	22.2%
11	Dengue Fever	21.8%
12	Yellow Fever	21.8%
13	Hemorrhagic Fever, Crimean	21.7%
14	Hepatitis, Viral, Animal	20.2%
15	Hemorrhagic Fever, American	20%
16	Lassa Fever	20%
17	Orthomyxoviridae Infections	19.5%
18	Reoviridae Infections	19.5%
19	Retroviridae Infections	19.5%
20	Phlebotomus Fever	18.9%
21	Foot-and-Mouth Disease	18.8%
22	Arbovirus Infections	18.4%
23	Common Cold	18.2%
24	Catarrh	18.2%
25	Hepatitis, Chronic	17.5%
26	Chronic active hepatitis	17.5%
27	Hemorrhagic Fever with Renal Syndrome	17.2%
28	Warts	16.9%
29	Poliomyelitis	16.6%
30	Hepatitis, Alcoholic	16.5%
31	Zika Virus Infection	16.1%
32	Murine Acquired Immunodeficiency Syndrome	15.9%
33	West Nile Fever	15.1%
34	Epstein-Barr Virus Infections	14.9%
35	Hepatitis, Animal	14.6%
36	Viremia	14.4%
37	Subacute Sclerosing Panencephalitis	14.2%
38	Condylomata Acuminata	14%
39	Acquired Immunodeficiency Syndrome	13.8%
40	AIDS related complex	13.8%
41	Simian Acquired Immunodeficiency Syndrome	13.4%
42	Fatty Liver	12.7%
43	Portal Hypertension	12.7%
44	Liver Cirrhosis	12.7%
45	Focal Nodular Hyperplasia	12.7%
46	Hepatic Insufficiency	12.7%
47	Steatohepatitis	12.7%
48	Opportunistic Infections	12.7%
49	Flavivirus Infections	12.5%
50	Paramyxoviridae Infections	12.5%
51	Rhabdoviridae Infections	12.5%
52	Molluscum Contagiosum	12.3%
53	Leukoencephalopathy, Progressive Multifocal	12.2%
54	Pneumonia, Viral	12.1%
55	Epidermodysplasia Verruciformis	11.8%
56	Liver neoplasms	11.4%
57	HIV Infections	11.2%
58	Herpesviridae Infections	11%
59	Polyomavirus Infections	11%
60	Pseudorabies	10.8%
61	Biliary cirrhosis	10.7%
62	Herpes Zoster Ophthalmicus	10.6%
63	Liver Diseases, Parasitic	10.6%
64	Erythema Infectiosum	10.5%
65	Chronic Fatigue Syndrome	10.5%
66	Sexually Transmitted Diseases	10.5%
67	Hepatic Veno-Occlusive Disease	10.3%
68	Peliosis Hepatis	10.3%
69	Hepatopulmonary Syndrome	10.3%
70	Hepatomegaly	10.1%
71	Influenza	10.1%
72	Hepatic Vein Thrombosis	10%
73	Liver Abscess	10%
74	Budd-Chiari Syndrome	10%
75	Fatty Liver, Alcoholic	9.9%
76	Liver Cirrhosis, Alcoholic	9.9%
77	Keratitis, Herpetic	9.6%
78	Cytomegalovirus Retinitis	9.6%
79	Exanthema Subitum	9.5%
80	Autoimmune hepatitis	9.4%
81	AIDS-Related Opportunistic Infections	9.3%
82	Rubella	9.1%
83	Coronavirus Infections	9.1%
84	Nipah Virus Infection	9.1%
85	Hydrophobia	9.1%
86	HIV Seropositivity	8.8%
87	Eczema Herpeticum	8.8%
88	Chemical and Drug Induced Liver Injury	8.6%
89	Hepatorenal Syndrome	8.4%
90	Esophageal and Gastric Varices	8%
91	Biliary Tract Diseases	7.9%
92	Gastrointestinal Diseases	7.9%
93	Pancreatic Diseases	7.9%
94	Genital Herpes	7.7%
95	Herpes Labialis	7.5%
96	Liver Abscess, Amebic	7.5%
97	Cytomegalovirus Infections	7.5%
98	Smallpox	7.5%
99	Liver Failure	7.5%
100	Non-alcoholic Fatty Liver Disease	7.5%
101	Varicella Zoster Virus Infection	7.5%
102	Measles	7.4%
103	Respiratory Syncytial Virus Infections	7.4%
104	Superinfection	7.4%
105	Porcine Reproductive and Respiratory Syndrome	7.4%
106	HTLV-I Infections	7.3%
107	Porphyrias, Hepatic	7.2%
108	Picornaviridae Infections	6.8%
109	HIV Wasting Syndrome	6.6%
110	AIDS Dementia Complex	6.6%
111	AIDS-Associated Nephropathy	6.6%
112	Burkitt Lymphoma	6.5%
113	Digestive System Neoplasms	6.3%
114	Vesicular Stomatitis	6.3%
115	Hepatitis, Viral, Human	6.2%
116	Gastroenteritis, Transmissible, of Swine	6%
117	Severe Acute Respiratory Syndrome	6%
118	Liver Cirrhosis, Experimental	6%
119	Mumps	5.9%
120	HIV-Associated Lipodystrophy Syndrome	5.8%
121	Chickenpox	5.8%
122	Gastrointestinal Neoplasms	5.7%
123	Hepatocellular Adenoma	5.7%
124	Pancreatic Fistula	5.6%
125	Hepatitis A	5.6%
126	Zollinger-Ellison syndrome	5.1%
127	Fascioliasis	5.1%
128	Echinococcosis, Hepatic	5%
129	Enterovirus Infections	5%
130	Liver Neoplasms, Experimental	5%
131	Chemical and Drug Induced Liver Injury, Chronic	5%
132	Reye Syndrome	5%
133	Liver Failure, Acute	5%
134	End Stage Liver Disease	5%
135	Peritoneal Neoplasms	4.9%
136	Mesenteric vascular insufficiency	4.5%
137	Esophageal Atresia	4.5%
138	Intestinal Atresia	4.5%
139	Mesenteric Vascular Occlusion	4.5%
140	Intestinal Fistula	4.5%
141	Enterocutaneous Fistula	4.5%
142	Bell Palsy	4.3%
143	Pancreatic Neoplasm	4.3%
144	Bile Duct Neoplasms	4.3%
145	gallbladder neoplasm	4.3%
146	Intestinal Neoplasms	4.3%
147	Stomach Neoplasms	4.3%
148	Bile Duct Diseases	4.2%
149	Cholelithiasis	4.2%
150	Chylous Ascites	4.2%
151	Esophageal Diseases	4.2%
152	Gastroenteritis	4.2%
153	Intestinal Diseases	4.2%
154	Pancreatic Insufficiency	4.2%
155	Pancreatitis	4.2%
156	Pneumoperitoneum	4.2%
157	Stomach Diseases	4.2%
158	Variegate Porphyria	4.2%
159	Acute intermittent porphyria	4.2%
160	Porphyria Cutanea Tarda	4.2%
161	Dysentery	4%
162	Enteritis	4%
163	Enterocolitis	4%
164	Esophagitis	4%
165	Gastritis	4%
166	Inflammatory Bowel Diseases	4%
167	Cholecystolithiasis	4%
168	Choledochal Cyst	3.9%
169	Zellweger Syndrome	3.8%
170	Esophageal Neoplasms	3.7%
171	Massive Hepatic Necrosis	3.7%
172	Colorectal Neoplasms	3.6%
173	Hepatolenticular Degeneration	3.5%
174	Proctocolitis	3.4%
175	Pancreatic Cyst	3.4%
176	Anus, Imperforate	3.4%
177	Gastrointestinal Hemorrhage	3.4%
178	Hemoperitoneum	3.4%
179	Mesenteric Panniculitis	3.4%
180	Panniculitis, Peritoneal	3.4%
181	Peritonitis	3.4%
182	Peritoneal Fibrosis	3.4%
183	Encapsulating Peritoneal Sclerosis	3.4%
184	Anorectal Malformations	3.4%
185	Biliary Fistula	3.4%
186	Gastric Fistula	3.4%
187	Tuberculosis, Gastrointestinal	3.3%
188	Infectious Mononucleosis	3.3%
189	Gastrointestinal Stromal Tumors	3.3%
190	Colitis	3.3%
191	Duodenogastric Reflux	3.3%
192	Peptic Ulcer	3.3%
193	Proctitis	3.3%
194	Choledocholithiasis	3.3%
195	Hepatic Encephalopathy	3.3%
196	Duodenitis	3.3%
197	Ileitis	3.3%
198	Rectal Fistula	3.3%
199	Anal Fistula	3.3%
200	Erosive Duodenitis	3.3%
201	Cecal Neoplasms	3.3%
202	Duodenal Neoplasms	3.3%
203	Herpes Zoster Oticus	2.9%
204	Appendicitis	2.8%
205	Crohn Disease	2.6%
206	Duodenal Obstruction	2.6%
207	Enterocolitis, Neutropenic	2.6%
208	Necrotizing Enterocolitis	2.6%
209	Cecal Diseases	2.5%
210	Cholangitis	2.5%
211	Cholecystitis	2.5%
212	Cholestasis	2.5%
213	Colonic Diseases	2.5%
214	Common Bile Duct Diseases	2.5%
215	Esophageal Stenosis	2.5%
216	Ileal Diseases	2.5%
217	Intestinal Obstruction	2.5%
218	Intestinal Perforation	2.5%
219	Jejunal Diseases	2.5%
220	Pneumatosis Cystoides Intestinalis	2.5%
221	Rectal Diseases	2.5%
222	Gastric Dilatation	2.5%
223	Pancreatitis, Chronic	2.5%
224	Gastric outlet obstruction	2.5%
225	Cronkhite-Canada Syndrome	2.5%
226	Intestinal Polyposis	2.5%
227	Cystic Fibrosis	2.5%
228	Pouchitis	2.4%
229	Appendiceal Neoplasms	2.4%
230	Colonic Neoplasms	2.4%
231	Rectal Neoplasms	2.4%
232	Congenital Hyperinsulinism	2.4%
233	Anus Neoplasms	2.3%
234	Sigmoid Neoplasms	2.3%
235	Duodenal Ulcer	2.3%
236	Peptic Ulcer Perforation	2.3%
237	Gastric ulcer	2.3%
238	Enterocolitis, Pseudomembranous	2.2%
239	pseudomembranous colitis	2.2%
240	Dysentery, Bacillary	2.2%
241	Adenomatous Polyposis Coli	2.2%
242	Esophageal Perforation	2.1%
243	Intestinal Diseases, Parasitic	2.1%
244	Barrett Esophagus	2%
245	Deglutition Disorders	2%
246	Achlorhydria	2%
247	Pancreatic Pseudocyst	2%
248	Gastric Antral Vascular Ectasia	2%
249	Peptic Ulcer Hemorrhage	2%
250	Gastroparesis	2%
251	Pancreatitis, Alcoholic	2%
252	Carcinoma, Pancreatic Ductal	2%
253	Colitis, Ischemic	1.9%
254	Colonic Pseudo-Obstruction	1.8%
255	Melena	1.7%
256	Cholestasis, Extrahepatic	1.7%
257	Biliary Dyskinesia	1.7%
258	Cholangitis, Sclerosing	1.7%
259	Colonic Diseases, Functional	1.7%
260	Esophageal motility disorders	1.7%
261	Fecal Incontinence	1.7%
262	Fecal Impaction	1.7%
263	Intussusception	1.7%
264	Mallory-Weiss Syndrome	1.7%
265	Megacolon	1.7%
266	Pyloric Stenosis	1.7%
267	Acalculous Cholecystitis	1.7%
268	Ileus	1.7%
269	Meconium ileus	1.7%
270	Hematemesis	1.6%
271	insulinoma	1.4%
272	Gastrinoma	1.4%
273	Glucagonoma	1.4%
274	Nesidioblastosis	1.4%
275	Hemorrhoids	1.3%
276	Afferent Loop Syndrome	1.3%
277	Celiac Disease	1.3%
278	Short Bowel Syndrome	1.3%
279	Sprue, Tropical	1.3%
280	Steatorrhea	1.3%
281	Rectocele	1.3%
282	Sprue	1.3%
283	Diverticulitis	1.3%
284	Dumping Syndrome	1.3%
285	Rectal Prolapse	1.3%
286	Vipoma	1.3%
287	Esophageal Achalasia	1.2%
288	Anal Fissure	1.2%
289	Intestinal Pseudo-Obstruction	1.2%
290	Irritable Bowel Syndrome	1.2%
291	Superior Mesenteric Artery Syndrome	1.2%
292	Emphysematous Cholecystitis	1.2%
293	Neurogenic Bowel	1.2%
294	Sphincter of Oddi Dysfunction	1.2%
295	Anal Ulcer	1.2%
296	Giardiasis	1.1%
297	Diverticulum	1.1%
298	Diverticulosis	1.1%
299	Pruritus Ani	1%
300	Peutz-Jeghers Syndrome	0.9%
301	Lactose Intolerance	0.9%
302	Laryngopharyngeal Reflux	0.8%
303	Cryptosporidiosis	0.7%
304	CREST Syndrome	0.5%

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