MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Enterocolitis, Pseudomembranous

(UMLS:C0014358)

Definition:: An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.
UMLS ID:: C0014358
MeSH ID:: D004761

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.222.310

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.205.596.800|C06.405.469.363.800

Synonym(s)

Enterocolitis, Pseudomembranous

PSEUDOMEMBRANOUS ENTEROCOLITIS

Pseudomembramous enterocolitis

enterocolitis pseudomembranous

pseudomembranous enterocolitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Chlorpropamide	2859803	CTD
2	Clindamycin	519356 955507 7089634	CTD
3	Lincomycin	6657545 7089634	CTD
4	Metronidazole	10830559 12642754 15869686	CTD
5	Paclitaxel	11468447	CTD
6	Vancomycin	2859803 6853034 12642754	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Enterocolitis, Neutropenic	46.5%
2	Necrotizing Enterocolitis	46.5%
3	Dysentery	39.2%
4	Enteritis	39.2%
5	Inflammatory Bowel Diseases	39.2%
6	Proctocolitis	34.1%
7	Colitis	32.5%
8	Proctitis	32.5%
9	Zollinger-Ellison syndrome	32.4%
10	Duodenitis	32.3%
11	Ileitis	32.3%
12	Erosive Duodenitis	32.3%
13	Esophagitis	31.4%
14	Gastritis	31.4%
15	Appendicitis	28.8%
16	Colorectal Neoplasms	27.2%
17	Crohn Disease	25.8%
18	Duodenal Obstruction	25.8%
19	Tuberculosis, Gastrointestinal	25.4%
20	Intestinal Neoplasms	25.2%
21	Esophageal Diseases	24.8%
22	Stomach Diseases	24.8%
23	Dysentery, Bacillary	24.7%
24	Duodenogastric Reflux	24.7%
25	Peptic Ulcer	24.7%
26	Cecal Diseases	24.4%
27	Colonic Diseases	24.4%
28	Ileal Diseases	24.4%
29	Intestinal Obstruction	24.4%
30	Intestinal Perforation	24.4%
31	Jejunal Diseases	24.4%
32	Pneumatosis Cystoides Intestinalis	24.4%
33	Rectal Diseases	24.4%
34	Cronkhite-Canada Syndrome	24.4%
35	Intestinal Polyposis	24.4%
36	Gas Gangrene	24.2%
37	Tetanus	24.2%
38	Pouchitis	24%
39	Cecal Neoplasms	22.5%
40	Duodenal Neoplasms	22.5%
41	Gastrointestinal Neoplasms	22.3%
42	Mesenteric vascular insufficiency	22.3%
43	Intestinal Atresia	22.1%
44	Mesenteric Vascular Occlusion	22.1%
45	Intestinal Fistula	22%
46	Enterocutaneous Fistula	22%
47	Rectal Fistula	21.2%
48	Anal Fistula	21.2%
49	Intestinal Diseases, Parasitic	20.4%
50	Gastrointestinal Hemorrhage	19.9%
51	Stomach Neoplasms	19.6%
52	Colitis, Ischemic	19.1%
53	Anus Neoplasms	17.6%
54	Sigmoid Neoplasms	17.6%
55	Colonic Pseudo-Obstruction	17.6%
56	Duodenal Ulcer	17.4%
57	Peptic Ulcer Perforation	17.4%
58	Gastric ulcer	17.4%
59	Esophageal Neoplasms	17.2%
60	Actinomycetales Infections	17.1%
61	Listeriosis	17.1%
62	Staphylococcal Infections	17.1%
63	Streptococcal Infections	17.1%
64	Bacillaceae Infections	17.1%
65	Appendiceal Neoplasms	16.7%
66	Colonic Neoplasms	16.7%
67	Rectal Neoplasms	16.7%
68	Adenomatous Polyposis Coli	16.7%
69	Colonic Diseases, Functional	16.1%
70	Fecal Incontinence	16.1%
71	Fecal Impaction	16.1%
72	Intussusception	16.1%
73	Megacolon	16.1%
74	Ileus	16.1%
75	Meconium ileus	16.1%
76	Esophageal and Gastric Varices	15.7%
77	Esophageal Atresia	15.5%
78	Biliary Tract Diseases	15.4%
79	Liver diseases	15.4%
80	Pancreatic Diseases	15.4%
81	Esophageal Stenosis	14.6%
82	Gastric Dilatation	14.6%
83	Gastric outlet obstruction	14.6%
84	Erysipelothrix infection	14.3%
85	Diverticulitis	14.2%
86	Botulism	14.2%
87	Hemorrhoids	13.2%
88	Gastrointestinal Stromal Tumors	13%
89	Afferent Loop Syndrome	13%
90	Celiac Disease	13%
91	Short Bowel Syndrome	13%
92	Sprue, Tropical	13%
93	Steatorrhea	13%
94	Rectocele	13%
95	Sprue	13%
96	Rectal Prolapse	12.9%
97	Impetigo	12.8%
98	Digestive System Neoplasms	12.4%
99	Gastroenteritis	12.4%
100	Intestinal Diseases	12.4%
101	Gram-Negative Bacterial Infections	12.4%
102	Esophageal Perforation	12.2%
103	Anal Fissure	12%
104	Intestinal Pseudo-Obstruction	12%
105	Irritable Bowel Syndrome	12%
106	Superior Mesenteric Artery Syndrome	12%
107	Neurogenic Bowel	12%
108	Anal Ulcer	12%
109	Diverticulum	12%
110	Diverticulosis	12%
111	Barrett Esophagus	11.9%
112	Deglutition Disorders	11.9%
113	Achlorhydria	11.8%
114	Borrelia Infections	11.8%
115	Enterocolitis	11.8%
116	Leptospirosis	11.8%
117	Gastric Antral Vascular Ectasia	11.8%
118	Peptic Ulcer Hemorrhage	11.7%
119	Gastroparesis	11.7%
120	Erysipelas	11.6%
121	Staphylococcal Skin Infections	11.6%
122	Actinomycosis	11.3%
123	Corynebacterium Infections	11.3%
124	Mycobacterium Infections	11.3%
125	Nocardia Infections	11.3%
126	Pneumococcal Infections	11.3%
127	Scarlet Fever	11.3%
128	Pulmonary Nocardiosis	11.3%
129	Liver neoplasms	11.2%
130	Central Nervous System Bacterial Infections	11.2%
131	Giardiasis	11.1%
132	Pancreatic Fistula	11.1%
133	Ecthyma	10.2%
134	Subacute Bacterial Endocarditis	10.2%
135	Skin Diseases, Bacterial	9.9%
136	Erythrasma	9.9%
137	Melena	9.9%
138	Bacteremia	9.9%
139	Bacterial Vaginosis	9.8%
140	Hematemesis	9.7%
141	Pruritus Ani	9.7%
142	Esophageal motility disorders	9.7%
143	Lyme Disease	9.7%
144	Mallory-Weiss Syndrome	9.7%
145	Pyloric Stenosis	9.7%
146	Relapsing Fever	9.7%
147	Peritoneal Neoplasms	9.6%
148	Peutz-Jeghers Syndrome	9.4%
149	Lactose Intolerance	9.3%
150	Meningitis, Listeria	9.2%
151	Lyme Neuroborreliosis	9.1%
152	Bacterial Endocarditis	8.6%
153	Peritonitis	8.6%
154	Mycetoma	8.6%
155	Pancreatic Neoplasm	8.4%
156	Diphtheria	8.4%
157	Leprosy	8.4%
158	Mycobacterium Infections, Nontuberculous	8.4%
159	Tuberculosis	8.4%
160	Mycobacterium abscessus Infection	8.4%
161	Bile Duct Neoplasms	8.4%
162	gallbladder neoplasm	8.4%
163	Neurosyphilis	8.3%
164	Pneumonia, Bacterial	8.3%
165	Bile Duct Diseases	8.3%
166	Cholelithiasis	8.3%
167	Chylous Ascites	8.3%
168	Fatty Liver	8.3%
169	Hepatitis	8.3%
170	Portal Hypertension	8.3%
171	Liver Cirrhosis	8.3%
172	Pancreatic Insufficiency	8.3%
173	Pancreatitis	8.3%
174	Pneumoperitoneum	8.3%
175	Focal Nodular Hyperplasia	8.3%
176	Hepatic Insufficiency	8.3%
177	Steatohepatitis	8.3%
178	Syphilis	8.3%
179	Staphylococcal Scalded Skin Syndrome	8.2%
180	Biliary cirrhosis	8.1%
181	Erythema Chronicum Migrans	7.9%
182	Cholecystolithiasis	7.8%
183	Dumping Syndrome	7.7%
184	Human Ehrlichiosis	7.7%
185	Mycoses	7.7%
186	Rheumatic Fever	7.7%
187	Infection	7.7%
188	Choledochal Cyst	7.7%
189	Meningitis, Pneumococcal	7.6%
190	Liver Abscess	7.5%
191	Cryptosporidiosis	7.4%
192	Bordetella Infections	7.3%
193	Brucellosis	7.3%
194	Campylobacter infection	7.3%
195	Enterobacteriaceae Infections	7.3%
196	Pseudomonas Infections	7.3%
197	Q Fever	7.3%
198	Vibrio Infections	7.3%
199	Helicobacter Infections	7.3%
200	Neisseriaceae Infections	7.3%
201	Burkholderia Infections	7.3%
202	Flavobacteriaceae Infections	7.3%
203	Moraxellaceae Infections	7.3%
204	Burkholderia cepacia Infection	7.3%
205	Furunculosis	7.3%
206	furuncle	7.3%
207	Esophageal Achalasia	7.2%
208	Mycobacterium avium-intracellulare Infection	7%
209	Lymph Node Tuberculosis	7%
210	Tuberculosis, Miliary	7%
211	Tuberculosis, Multidrug-Resistant	7%
212	Leprosy, Multibacillary	7%
213	Latent Tuberculosis	7%
214	Liver Diseases, Parasitic	6.9%
215	Rheumatic Heart Disease	6.9%
216	Chlamydia Infections	6.9%
217	Gonorrhea	6.9%
218	Japanese Spotted Fever	6.8%
219	Hepatic Veno-Occlusive Disease	6.7%
220	Pancreatic Cyst	6.7%
221	Peliosis Hepatis	6.7%
222	Hepatopulmonary Syndrome	6.7%
223	Human anaplasmosis	6.7%
224	Anus, Imperforate	6.6%
225	Hemoperitoneum	6.6%
226	Hepatomegaly	6.6%
227	Mesenteric Panniculitis	6.6%
228	Panniculitis, Peritoneal	6.6%
229	Peritoneal Fibrosis	6.6%
230	Encapsulating Peritoneal Sclerosis	6.6%
231	Anorectal Malformations	6.6%
232	carbuncle	6.6%
233	Biliary Fistula	6.6%
234	Gastric Fistula	6.6%
235	Hepatic Vein Thrombosis	6.6%
236	Budd-Chiari Syndrome	6.6%
237	Fatty Liver, Alcoholic	6.5%
238	Hepatitis, Alcoholic	6.5%
239	Liver Cirrhosis, Alcoholic	6.5%
240	Choledocholithiasis	6.5%
241	Enterocolitis, Pseudomembranous	6.5%
242	pseudomembranous colitis	6.5%
243	Joint Tuberculosis	6.4%
244	Tuberculosis, Osteoarticular	6.4%
245	Bone Tuberculosis	6.4%
246	Borderline leprosy	6.3%
247	Leprosy, Lepromatous	6.3%
248	Tuberculoid leprosy	6.3%
249	Extensively Drug-Resistant Tuberculosis	6.3%
250	Central Nervous System Infection	6.2%
251	Hidradenitis Suppurativa	5.7%
252	Chemical and Drug Induced Liver Injury	5.6%
253	Tuberculosis, Central Nervous System	5.6%
254	Hepatocellular Adenoma	5.6%
255	Tuberculosis, Meningeal	5.6%
256	Hepatorenal Syndrome	5.5%
257	Liver Abscess, Amebic	5.5%
258	Rocky Mountain Spotted Fever	5.3%
259	Hordeolum	5.2%
260	Ulcerative stomatitis	5.2%
261	Rhinoscleroma	5.2%
262	Bacterial conjunctivitis	5.1%
263	Erythema Induratum	5%
264	Pertussis	4.9%
265	Liver Neoplasms, Experimental	4.9%
266	Laryngopharyngeal Reflux	4.9%
267	Syphilis, Congenital	4.9%
268	Meningitis, Bacterial	4.9%
269	Cholangitis	4.9%
270	Cholecystitis	4.9%
271	Cholestasis	4.9%
272	Common Bile Duct Diseases	4.9%
273	Cystic Fibrosis	4.9%
274	Hepatitis, Chronic	4.9%
275	Liver Failure	4.9%
276	Pancreatitis, Chronic	4.9%
277	Non-alcoholic Fatty Liver Disease	4.9%
278	Chronic active hepatitis	4.9%
279	Tuberculosis, Pulmonary	4.8%
280	Acinetobacter Infections	4.8%
281	Bacteroides Infections	4.8%
282	Cholera	4.8%
283	Escherichia coli Infections	4.8%
284	Haemophilus Infections	4.8%
285	Klebsiella Infections	4.8%
286	Meningococcal Infections	4.8%
287	Mycoplasma Infections	4.8%
288	Pasteurella Infections	4.8%
289	Proteus Infections	4.8%
290	Rickettsia Infections	4.8%
291	Salmonella infections	4.8%
292	Scrub Typhus	4.8%
293	Serratia Infections	4.8%
294	Ureaplasma Infections	4.8%
295	Meningitis, Haemophilus	4.8%
296	Lymphogranuloma Venereum	4.8%
297	Porphyrias, Hepatic	4.7%
298	Congenital Hyperinsulinism	4.7%
299	Tuberculosis, Spinal	4.5%
300	Dermatomycoses	4.4%
301	Ophthalmia Neonatorum	4.3%
302	Trachoma	4.3%
303	Aspergillosis	4.1%
304	Candidiasis	4.1%
305	Coccidioidomycosis	4.1%
306	Histoplasmosis	4.1%
307	Paracoccidioidomycosis	4.1%
308	Pelvic Infection	4.1%
309	Wound Infection	4.1%
310	Zygomycosis	4.1%
311	Soft Tissue Infection	4.1%
312	Community-Acquired Infections	4.1%
313	Phaeohyphomycosis	4.1%
314	Pneumocystis Infections	4.1%
315	Hepatitis, Animal	4.1%
316	Hepatitis, Viral, Human	4.1%
317	Liver Cirrhosis, Experimental	3.9%
318	Pancreatic Pseudocyst	3.9%
319	Pancreatitis, Alcoholic	3.9%
320	Carcinoma, Pancreatic Ductal	3.9%
321	Candidiasis, Chronic Mucocutaneous	3.7%
322	Cutaneous Candidiasis	3.7%
323	Psittacosis	3.6%
324	Paratyphoid Fever	3.6%
325	Plague	3.6%
326	Typhoid Fever	3.6%
327	TYPHUS	3.6%
328	Yersinia pseudotuberculosis Infections	3.6%
329	Bubonic Plague	3.6%
330	Panophthalmitis	3.5%
331	Eye Infection	3.4%
332	Respiratory Tract Infections	3.4%
333	Bone Diseases, Infectious	3.4%
334	Otomycosis	3.4%
335	Pregnancy Complications, Infectious	3.4%
336	Skin Diseases, Infectious	3.4%
337	Fascioliasis	3.3%
338	Arthritis, Infectious	3.3%
339	Piedra	3.3%
340	Central Nervous System Fungal Infections	3.3%
341	Suppuration	3.3%
342	Brain Abscess	3.3%
343	Echinococcosis, Hepatic	3.3%
344	Cross Infection	3.3%
345	Septicemia	3.3%
346	Sepsis	3.3%
347	Chemical and Drug Induced Liver Injury, Chronic	3.3%
348	Reye Syndrome	3.3%
349	Neuroaspergillosis	3.3%
350	Fungemia	3.3%
351	Hepatitis B, Chronic	3.2%
352	Hepatitis C, Chronic	3.2%
353	CREST Syndrome	3.2%
354	Tuberculosis, Renal	3.2%
355	Cholestasis, Extrahepatic	3.2%
356	Biliary Dyskinesia	3.2%
357	Cholangitis, Sclerosing	3.2%
358	Liver Failure, Acute	3.2%
359	Acalculous Cholecystitis	3.2%
360	End Stage Liver Disease	3.2%
361	Candidemia	3.2%
362	Salmonella Infections, Animal	3%
363	Opportunistic Infections	3%
364	Salmonella food poisoning	2.9%
365	Blastomycosis	2.9%
366	insulinoma	2.9%
367	Gastrinoma	2.8%
368	Glucagonoma	2.8%
369	Cellulitis	2.8%
370	Lung Diseases, Fungal	2.8%
371	Urinary tract infection	2.8%
372	Nesidioblastosis	2.8%
373	Variegate Porphyria	2.8%
374	Acute intermittent porphyria	2.8%
375	Porphyria Cutanea Tarda	2.8%
376	Chromoblastomycosis	2.7%
377	Dermatophytosis	2.7%
378	Sporotrichosis	2.7%
379	Tinea	2.7%
380	Tinea Versicolor	2.7%
381	Trichophytosis	2.7%
382	Invasive Pulmonary Aspergillosis	2.7%
383	Hyalohyphomycosis	2.7%
384	Endotoxemia	2.7%
385	Autoimmune hepatitis	2.6%
386	Vipoma	2.6%
387	Zellweger Syndrome	2.5%
388	Sexually Transmitted Diseases	2.5%
389	Mucormycosis	2.4%
390	Massive Hepatic Necrosis	2.4%
391	Emphysematous Cholecystitis	2.4%
392	Sphincter of Oddi Dysfunction	2.4%
393	Hepatolenticular Degeneration	2.3%
394	Meningitis, Cryptococcal	2.3%
395	Hepatitis, Viral, Animal	2.3%
396	Hepatitis E	2.2%
397	Waterhouse-Friderichsen Syndrome	2.2%
398	Hepatitis B	2.2%
399	Hepatitis C	2.2%
400	Hepatitis A	2.2%
401	Hepatic Encephalopathy	2.2%
402	Oral candidiasis	2%
403	Endophthalmitis	2%
404	Osteomyelitis	2%
405	Periostitis	2%
406	Surgical Wound Infection	2%
407	Pulmonary Aspergillosis	2%
408	Bronchopulmonary Aspergillosis	2%
409	Abscess	1.9%
410	Adnexitis	1.9%
411	Empyema	1.9%
412	Pelvic Inflammatory Disease	1.9%
413	Fusariosis	1.9%
414	Superinfection	1.7%
415	Corneal Ulcer	1.7%
416	Puerperal Infection	1.6%
417	Spondylitis	1.6%
418	Lemierre Syndrome	1.6%
419	Bacteriuria	1.6%
420	Pyuria	1.6%
421	Meningitis, Fungal	1.6%
422	Pyomyositis	1.6%
423	Endotoxic shock	1.6%
424	Septic Shock	1.6%
425	Toxic Shock Syndrome	1.6%
426	Tinea Capitis	1.6%
427	Onychomycosis	1.6%
428	Psoas Abscess	1.6%
429	Abdominal Abscess	1.6%
430	Candidiasis, Vulvovaginal	1.6%
431	Toxoplasmosis, Cerebral	1.5%
432	Tinea Pedis	1.4%
433	Arthritis, Reactive	1.4%
434	AIDS-Related Opportunistic Infections	1.2%
435	Lung Abscess	1.1%
436	Rift Valley Fever	1.1%
437	Discitis	1.1%
438	Mastoiditis	1.1%
439	Petrositis	1.1%
440	Retropharyngeal Abscess	0.9%
441	Epidural Abscess	0.9%
442	Peritonsillar Abscess	0.9%
443	Aspergillosis, Allergic Bronchopulmonary	0.8%

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