MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Liver Cirrhosis, Experimental

(UMLS:C0023893)

Definition:: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
UMLS ID:: C0023893
MeSH ID:: D008106

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.630.467

Classification 2:

Name:

Investigative Techniques
MeSH Tree Number(s):: E05.598.500.468

Synonym(s)

Liver Cirrhosis, Experimental

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,3-dimethylthiourea	11682029	CTD
2	1-Methyl-3-isobutylxanthine	26806094	CTD
3	1-Naphthylisothiocyanate	25380136	CTD
4	17 alpha-Hydroxyprogesterone Caproate	1465320	CTD
5	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid	12958196 16033810	CTD
6	2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine	15723089	CTD
7	3,5-diethoxycarbonyl-1,4-dihydrocollidine	16015684	CTD
8	4,4'-diaminodiphenylmethane	25380136	CTD
9	4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide	12891558	CTD
10	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide	15876570	CTD
11	Acetaminophen	29355602	CTD
12	Adenosine	18263696	CTD
13	Alcohols	18166357 21863215 26115886	CTD
14	Aspirin	21360558	CTD
15	Atorvastatin	17347453	CTD
16	Azathioprine	8614026	CTD
17	BP 2-94	15506549	CTD
18	Betaine	18930038 30311401	CTD
19	Caffeine	24275088	CTD
20	Capsaicin	18555214	CTD
21	Carbon Tetrachloride	View details 1465320 2007767 6462789 7445625 8144103 8170719 8614026 10355542 10535884 11481614 12389079 12445418 12445421 12546737 12586293 12609069 12632512 12632514 12649538 12666154 12667390 12741479 12898905 12923366 12958196 13678700 14512876 14620537 14716496 14716833 14724832 14748882 15052691 15057751 15123356 15338365 15362042 15370692 15650968 15673190 15730626 15745444 15818738 15876570 15893842 15925388 15931870 15959796 15996030 16011737 16015684 16027843 16033810 16097048 16116963 16136751 16192424 16248980 16638106 17342914 17481882 17525996 17557913 17565644 17631135 17640975 17708605 17714472 17721639 17761835 17766677 17805973 17823541 17869086 17900296 17922224 17944888 17976157 18006644 18054572 18156304 18166357 18187930 18205269 18210741 18251166 18263696 18277467 18279442 18317297 18339082 18376398 18395095 18395914 18412020 18418968 18420326 18429990 18472094 18472332 18481824 18705752 19646978 20709091 20821823 21151953 21360558 22056649 23341968 23798564 23845850 24211420 24275088 24381012 25380136 25410024 25445725 25448286 25451574 25827057 26435214 26739621 26806094 27350269 27590029 27601294 27693115 27818223 27865848 28527913 29250925 29251412 29535048 30056145 30538632 30783172	CTD
22	Carmustine	25380136	CTD
23	Carnitine	14748882	CTD
24	Cesium-137	30311401	CTD
25	Chenodeoxycholic Acid	7445625	CTD
26	Choline	28133511	CTD
27	Colforsin	27590029	CTD
28	Cystamine	17708605	CTD
29	Cysteine	15158331	CTD
30	Dexamethasone	16718785 26806094	CTD
31	Diethylnitrosamine	View details 8144103 11981751 24275088 28943392	CTD
32	Dimethyl Sulfoxide	11682029	CTD
33	Dimethylformamide	25380136	CTD
34	Dimethylnitrosamine	View details 12493575 12918455 12925901 14568256 14643895 14659978 14709902 14726149 15067225 15081153 15086199 15099470 15138612 15161499 15298665 15339415 15366600 15369754 15383259 15479170 15492853 15504291 15571005 15577212 15591649 15723089 15733078 15744066 15763062 15793283 15798949 15842777 15864749 15942678 16009107 16042886 16169303 16270385 16544323 16570917 16603200 16627068 17036385 17196135 17198567 17201889 17203207 17348192 17432682 17465448 17534399 17640959 17666798 17719030 17724770 17881167 18095165 18210741 18237412 18239293 18364076 18371158 18567088 18629640 18637143 18672772 18930038 19589336 20422370 25380136	CTD
35	Dinoprostone	15816358	CTD
36	Doxorubicin	16439617 16595196	CTD
37	Emodin	15288473	CTD
38	Enalapril	17347453	CTD
39	Estradiol	14659978 14716833	CTD
40	Fenofibrate	15474484	CTD
41	Fosinopril	17900296	CTD
42	Genistein	17823541 25448286	CTD
43	Glutathione	15962377	CTD
44	Glycyrrhetinic Acid	23341968	CTD
45	Ibuprofen	21360558	CTD
46	Imatinib Mesylate	16596278	CTD
47	Indomethacin	18194892	CTD
48	Lisinopril	17900296	CTD
49	Losartan	12445418 15573910 17900296	CTD
50	Malondialdehyde	15962377	CTD
51	Melatonin	15298665 15925388 16703270	CTD
52	Methionine	15158331 28133511	CTD
53	Methotrexate	27605418	CTD
54	Mirtazapine	28623179	CTD
55	Nitric Oxide	15962377	CTD
56	Octreotide	12890342	CTD
57	Oleanolic Acid	10355542	CTD
58	Pentoxifylline	11788567 16703270	CTD
59	Perindopril	View details 15619341 16097048 16596278 16872305	CTD
60	Phenobarbital	2007767 17342914	CTD
61	Phosphatidylcholines	16169303	CTD
62	Pioglitazone	15052691 16484506	CTD
63	Poly I-C	18166357	CTD
64	Polychlorinated Dibenzodioxins	12878042	CTD
65	Praziquantel	24818384	CTD
66	Progesterone	1465320 6462789 8170719	CTD
67	Puromycin Aminonucleoside	16570917	CTD
68	Quercetin	12741479 27601294	CTD
69	Resveratrol	20422370 24818384	CTD
70	Retinaldehyde	16248980	CTD
71	Rosiglitazone	15980055 17347453	CTD
72	S-Adenosylmethionine	15983038	CTD
73	STF 083010	30538632	CTD
74	Scopoletin	26115886	CTD
75	Silymarin	View details 9303494 15754394 15864749 16169303 17198567 18277467 25410024 26115886 29250925	CTD
76	Sirolimus	10535884 17050028	CTD
77	Sulfasalazine	15633128	CTD
78	Tamoxifen	18564211	CTD
79	Taurine	15893842 15931870 25448286	CTD
80	Thalidomide	12923366 15465738	CTD
81	Thioacetamide	View details 10677585 11172339 11481614 11682029 12085344 12175628 12531686 12557150 12679928 12891558 14739098 15075984 15078482 15095483 15158331 15288472 15288473 15316131 15334695 15362042 15465738 15474484 15716488 16097051 16098781 16126171 16248980 16343077 16489207 16511523 17050028 17127702 17292413 17355460 17383642 17629604 18031379 18032466 18263696 18295389 18380797 18395095 18416461 18458672 18606216 18615449 21863215 23798564 24704557 27363783 27605418 28440100 28623179 28943392 29248466	CTD
82	Trabectedin	12154027	CTD
83	Tretinoin	16248980 18397230 21274875	CTD
84	Ursodeoxycholic Acid	21274875 21410058	CTD
85	Valsartan	15504291 15619341 16872305	CTD
86	Vinblastine	25380136	CTD
87	Vitamin A	16248980	CTD
88	Vitamin B 12	18239293	CTD
89	Vitamin E	16169303	CTD
90	Y 27632	13678700 30783172	CTD
91	allyl alcohol	11063159 18564211 25380136	CTD
92	alpha-naphthyl isocyanate	16015684	CTD
93	andrographolide	29355602	CTD
94	arginyl-glycyl-aspartic acid	15547672	CTD
95	baicalin	18187930	CTD
96	bicyclol	15730626 16603200	CTD
97	bisphenol A	27925325	CTD
98	calpain inhibitor III	15316131	CTD
99	candesartan cilexetil	14620537	CTD
100	cis-9, trans-11-conjugated linoleic acid	17869086	CTD
101	cobaltiprotoporphyrin	21163135	CTD
102	cucurbitacin B	29250925	CTD
103	cucurbitacin E	27363783	CTD
104	epigallocatechin gallate	17481882 19646978 25448286	CTD
105	farnesylthiosalicylic acid	15288472	CTD
106	fasudil	17761835	CTD
107	ferulic acid	16011737	CTD
108	gadolinium chloride	12666154	CTD
109	halofuginone	View details 11172339 12175628 14739098 16489207 18458672	CTD
110	idoxifene	14659978 15842777	CTD
111	lemon oil	29251412	CTD
112	morin	18629640	CTD
113	naringenin	14709902	CTD
114	obeticholic acid	15860571 15980055	CTD
115	oltipraz	16544323	CTD
116	oxymatrine	15633229 18395914	CTD
117	pirfenidone	12445421 15571005	CTD
118	pirinixic acid	15474484	CTD
119	pyrrolidine dithiocarbamic acid	15078482	CTD
120	reviparin	16904936	CTD
121	rhein	12546737	CTD
122	rofecoxib	17565644	CTD
123	salvianolic acid B	16009107	CTD
124	sauchinone	25451574	CTD
125	sesamol	25410024	CTD
126	tetrandrine	17201889	CTD
127	trichloromethyl free radical	20821823	CTD
128	turmeric extract	View details 17355460 18006644 18705752 23845850 27363783	CTD
129	vinpocetine	18277467	CTD
130	zinc protoporphyrin	21163135 23525258	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Biliary cirrhosis	28.1%
2	Liver Cirrhosis, Alcoholic	26.4%
3	Neoplasms, Experimental	24.6%
4	Arthritis, Experimental	23.3%
5	Fatty Liver	20.5%
6	Hepatitis	20.5%
7	Portal Hypertension	20.5%
8	Focal Nodular Hyperplasia	20.5%
9	Hepatic Insufficiency	20.5%
10	Steatohepatitis	20.5%
11	Diabetes Mellitus, Experimental	18.8%
12	Liver Neoplasms, Experimental	17.6%
13	Liver neoplasms	16.4%
14	Liver Diseases, Parasitic	16.1%
15	Fatty Liver, Alcoholic	15.8%
16	Hepatitis, Alcoholic	15.8%
17	Hepatic Veno-Occlusive Disease	15.5%
18	Peliosis Hepatis	15.5%
19	Hepatopulmonary Syndrome	15.5%
20	Hepatomegaly	15.3%
21	Hepatic Vein Thrombosis	15.1%
22	Liver Abscess	15.1%
23	Budd-Chiari Syndrome	15.1%
24	Leukemia, Experimental	14.1%
25	Mammary Neoplasms, Experimental	14.1%
26	Sarcoma, Experimental	14%
27	Esophageal and Gastric Varices	13.3%
28	Hepatitis, Chronic	13.3%
29	Liver Failure	13.3%
30	Non-alcoholic Fatty Liver Disease	13.3%
31	Chronic active hepatitis	13.3%
32	Radiation Injuries, Experimental	13.2%
33	Chemical and Drug Induced Liver Injury	12.5%
34	Hepatorenal Syndrome	12.1%
35	Biliary Tract Diseases	11.9%
36	Gastrointestinal Diseases	11.9%
37	Pancreatic Diseases	11.9%
38	Device Failure	11.9%
39	Neuritis, Autoimmune, Experimental	11.5%
40	Liver Abscess, Amebic	11.4%
41	Hepatitis, Animal	10.5%
42	Hepatitis, Viral, Human	10.5%
43	Electrophoresis	10.3%
44	Porphyrias, Hepatic	10.1%
45	Liver Failure, Acute	9.9%
46	End Stage Liver Disease	9.9%
47	Melanoma, Experimental	9.8%
48	Intubation	9.3%
49	Cytogenetic Analysis	9%
50	Hepatitis B, Chronic	9%
51	Hepatitis C, Chronic	9%
52	Digestive System Neoplasms	8.9%
53	Hepatocellular Adenoma	8.8%
54	Myasthenia Gravis, Autoimmune, Experimental	8.6%
55	Gastrointestinal Neoplasms	8.2%
56	Massive Hepatic Necrosis	8.2%
57	Pancreatic Fistula	8.2%
58	Fascioliasis	8.1%
59	Echinococcosis, Hepatic	8.1%
60	Chemical and Drug Induced Liver Injury, Chronic	8%
61	Reye Syndrome	7.9%
62	Zollinger-Ellison syndrome	7.9%
63	Autoimmune hepatitis	7.6%
64	Autopsy	7%
65	Microscopy	6.9%
66	Mesenteric vascular insufficiency	6.8%
67	Bile Duct Diseases	6.8%
68	Cholelithiasis	6.8%
69	Chylous Ascites	6.8%
70	Esophageal Diseases	6.8%
71	Gastric Lavage	6.8%
72	Gastroenteritis	6.8%
73	Intestinal Diseases	6.8%
74	Pancreatic Insufficiency	6.8%
75	Pancreatitis	6.8%
76	Peritoneal lavage	6.8%
77	Peritoneal Neoplasms	6.8%
78	Pneumoperitoneum	6.8%
79	Stomach Diseases	6.8%
80	Bronchoalveolar Lavage	6.8%
81	Esophageal Atresia	6.8%
82	Intestinal Atresia	6.8%
83	Mesenteric Vascular Occlusion	6.8%
84	Intestinal Fistula	6.7%
85	Enterocutaneous Fistula	6.7%
86	Dysentery	6.7%
87	Enteritis	6.7%
88	Enterocolitis	6.7%
89	Esophagitis	6.7%
90	Gastritis	6.7%
91	Inflammatory Bowel Diseases	6.7%
92	Cholecystolithiasis	6.7%
93	Bile Duct Neoplasms	6.6%
94	gallbladder neoplasm	6.6%
95	Intestinal Neoplasms	6.6%
96	Stomach Neoplasms	6.6%
97	Variegate Porphyria	6.6%
98	Acute intermittent porphyria	6.6%
99	Porphyria Cutanea Tarda	6.6%
100	Hepatitis, Viral, Animal	6.3%
101	Proctocolitis	6.2%
102	Hepatitis E	6.1%
103	Colorectal Neoplasms	6.1%
104	Hepatitis B	6%
105	Hepatitis C	6%
106	Hepatitis A	6%
107	Hepatic Encephalopathy	5.9%
108	Duodenitis	5.9%
109	Ileitis	5.9%
110	Pancreatic Neoplasm	5.9%
111	Erosive Duodenitis	5.9%
112	Colitis	5.8%
113	Duodenogastric Reflux	5.8%
114	Peptic Ulcer	5.8%
115	Proctitis	5.8%
116	Choledocholithiasis	5.8%
117	Esophageal Neoplasms	5.7%
118	Choledochal Cyst	5.7%
119	Cecal Neoplasms	5.6%
120	Duodenal Neoplasms	5.6%
121	Rectal Fistula	5.4%
122	Anal Fistula	5.4%
123	Gastrointestinal Stromal Tumors	5.3%
124	Pancreatic Cyst	5.2%
125	Anus, Imperforate	5.1%
126	Gastrointestinal Hemorrhage	5.1%
127	Hemoperitoneum	5.1%
128	Mesenteric Panniculitis	5.1%
129	Panniculitis, Peritoneal	5.1%
130	Peritonitis	5.1%
131	Prosthesis Failure	5.1%
132	Peritoneal Fibrosis	5.1%
133	Encapsulating Peritoneal Sclerosis	5.1%
134	Anorectal Malformations	5.1%
135	Biliary Fistula	5%
136	Gastric Fistula	5%
137	Immunosuppression	5%
138	Tuberculosis, Gastrointestinal	5%
139	Zellweger Syndrome	4.9%
140	Crohn Disease	4.9%
141	Duodenal Obstruction	4.9%
142	Enterocolitis, Neutropenic	4.9%
143	Necrotizing Enterocolitis	4.9%
144	Pouchitis	4.9%
145	Appendicitis	4.6%
146	Anus Neoplasms	4.6%
147	Sigmoid Neoplasms	4.6%
148	Appendiceal Neoplasms	4.6%
149	Colonic Neoplasms	4.6%
150	Rectal Neoplasms	4.6%
151	Hepatolenticular Degeneration	4.6%
152	Glasgow coma scale	4.5%
153	Duodenal Ulcer	4.5%
154	Peptic Ulcer Perforation	4.5%
155	Gastric ulcer	4.5%
156	Cecal Diseases	4.4%
157	Cholangitis	4.4%
158	Cholecystitis	4.4%
159	Cholestasis	4.4%
160	Colonic Diseases	4.4%
161	Common Bile Duct Diseases	4.4%
162	Esophageal Stenosis	4.4%
163	Ileal Diseases	4.4%
164	Intestinal Obstruction	4.4%
165	Intestinal Perforation	4.4%
166	Jejunal Diseases	4.4%
167	Pneumatosis Cystoides Intestinalis	4.4%
168	Polymerase Chain Reaction	4.4%
169	Rectal Diseases	4.4%
170	Gastric Dilatation	4.4%
171	Pancreatitis, Chronic	4.4%
172	Gastric outlet obstruction	4.4%
173	Cronkhite-Canada Syndrome	4.4%
174	Intestinal Polyposis	4.4%
175	Biopsy	4.1%
176	Enterocolitis, Pseudomembranous	3.9%
177	pseudomembranous colitis	3.9%
178	Dysentery, Bacillary	3.9%
179	Tuberculin Test	3.9%
180	Colonic Pseudo-Obstruction	3.9%
181	Adenomatous Polyposis Coli	3.8%
182	Colitis, Ischemic	3.7%
183	Amniocentesis	3.6%
184	Esophageal Perforation	3.5%
185	Intestinal Diseases, Parasitic	3.5%
186	Cystic Fibrosis	3.5%
187	Barrett Esophagus	3.4%
188	Deglutition Disorders	3.4%
189	Angioplasty	3.4%
190	Congenital Hyperinsulinism	3.4%
191	Achlorhydria	3.3%
192	Ovulation Induction	3.3%
193	Pancreatic Pseudocyst	3.3%
194	Gastric Antral Vascular Ectasia	3.3%
195	Peptic Ulcer Hemorrhage	3.3%
196	Gastroparesis	3.3%
197	Blood culture	3.3%
198	Pancreatitis, Alcoholic	3.3%
199	Cholestasis, Extrahepatic	3.3%
200	Biliary Dyskinesia	3.3%
201	Cholangitis, Sclerosing	3.3%
202	Colonic Diseases, Functional	3.3%
203	Esophageal motility disorders	3.3%
204	Fecal Incontinence	3.3%
205	Fecal Impaction	3.3%
206	Intussusception	3.3%
207	Mallory-Weiss Syndrome	3.3%
208	Megacolon	3.3%
209	Pyloric Stenosis	3.3%
210	Acalculous Cholecystitis	3.3%
211	Ileus	3.3%
212	Meconium ileus	3.3%
213	Immunoglobulin Therapy	3.3%
214	Rift Valley Fever	3.2%
215	Carcinoma, Pancreatic Ductal	2.9%
216	Esophageal Achalasia	2.7%
217	Anal Fissure	2.7%
218	Intestinal Pseudo-Obstruction	2.7%
219	Irritable Bowel Syndrome	2.7%
220	Superior Mesenteric Artery Syndrome	2.7%
221	Emphysematous Cholecystitis	2.7%
222	Neurogenic Bowel	2.7%
223	Sphincter of Oddi Dysfunction	2.7%
224	Anal Ulcer	2.7%
225	Melena	2.7%
226	Hematemesis	2.6%
227	Leukapheresis	2.6%
228	Hemorrhoids	2.5%
229	Afferent Loop Syndrome	2.5%
230	Celiac Disease	2.5%
231	Short Bowel Syndrome	2.5%
232	Sprue, Tropical	2.5%
233	Steatorrhea	2.5%
234	Rectocele	2.5%
235	Sprue	2.5%
236	Diverticulitis	2.5%
237	Dumping Syndrome	2.5%
238	Rectal Prolapse	2.5%
239	insulinoma	2.4%
240	Gastrinoma	2.4%
241	Glucagonoma	2.4%
242	Atherectomy	2.2%
243	Nesidioblastosis	2.2%
244	Body mass index	2.2%
245	Vipoma	2.1%
246	Pruritus Ani	2.1%
247	Giardiasis	2%
248	Diverticulum	2%
249	Diverticulosis	2%
250	PROTHROMBIN TIME	2%
251	Glucose tolerance test	2%
252	Superovulation	2%
253	Clot retraction	2%
254	Laryngopharyngeal Reflux	1.9%
255	Paracentesis	1.7%
256	venipuncture	1.7%
257	Peutz-Jeghers Syndrome	1.7%
258	Lactose Intolerance	1.6%
259	Body Height	1.6%
260	Body Weight	1.4%
261	Cryptosporidiosis	1.3%
262	Birth Weight	1.2%
263	CREST Syndrome	1%
264	Fetal Weight	0.9%

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