MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Sphincter of Oddi Dysfunction

(UMLS:C0878588)

Definition:: Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.
UMLS ID:: C0878588
MeSH ID:: D046628

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.130.120.250.098.800

Synonym(s)

Sphincter of Oddi Dysfunction

Dysfunction of sphincter of Oddi

Sphincter of Oddi dysfunction

sphincter oddi dysfunction

sphincter of oddi dysfunction

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	eluxadoline	FAERS: 70		US FAERS
2	telithromycin	FAERS: 5		OFFSIDES US FAERS
3	Fingolimod Hydrochloride	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Loperamide	FAERS: 3		US FAERS
5	Morphine	FAERS: 3	View details 1119938 1731556 3368250 3823361 6479537 9052925 9431903 9658871 11379694 11489400 12359295	CTD US FAERS
6	Codeine	FAERS: 2	9052925 15946633	CTD OFFSIDES US FAERS
7	Ketamine	FAERS: 2		US FAERS
8	acetaminophen, codeine drug combination	FAERS: 2		US FAERS
9	lenvatinib	FAERS: 2		US FAERS
10	Buprenorphine	FAERS: 1	12659611	CTD US FAERS
11	Cinacalcet	FAERS: 1		US FAERS
12	Codeine	FAERS: 1		US FAERS
13	Colesevelam Hydrochloride	FAERS: 1		US FAERS
14	Estradiol	FAERS: 1		US FAERS
15	Exenatide	FAERS: 1		US FAERS
16	Fentanyl	FAERS: 1		US FAERS
17	Fentanyl	FAERS: 1	1119938 6828978	CTD US FAERS
18	Isotretinoin	FAERS: 1		US FAERS
19	Levetiracetam	FAERS: 1		US FAERS
20	Methylprednisolone	FAERS: 1		US FAERS
21	Metoprolol	FAERS: 1		US FAERS
22	Octreotide	FAERS: 1		OFFSIDES US FAERS
23	Octreotide	FAERS: 1		US FAERS
24	Prednisone	FAERS: 1		US FAERS
25	desloratadine	FAERS: 1		US FAERS
26	etonogestrel	FAERS: 1		US FAERS
27	Alendronate			OFFSIDES
28	Aminophylline		9658871	CTD
29	Amoxicillin			OFFSIDES
30	Atropine			OFFSIDES
31	Cefotaxime			OFFSIDES
32	Ceruletide		6479537	CTD
33	Clindamycin			OFFSIDES
34	Duloxetine Hydrochloride			OFFSIDES
35	Erythromycin			OFFSIDES
36	Etodolac			OFFSIDES
37	Etoposide			OFFSIDES
38	Hydromorphone			OFFSIDES
39	Hydroxyzine			OFFSIDES
40	Lactulose			OFFSIDES
41	Meloxicam			OFFSIDES
42	Meperidine		12659611	CTD
43	Nalbuphine		1731556	CTD
44	Naloxone		666027 6828978 11489400	CTD
45	Neostigmine		9431903	CTD
46	Nitroglycerin		9431903 11379694	CTD
47	Piperacillin, Tazobactam Drug Combination			OFFSIDES
48	Propafenone			OFFSIDES
49	Scopolamine			OFFSIDES
50	Terbutaline			OFFSIDES
51	Theophylline		9658871	CTD
52	Topiramate			OFFSIDES
53	Valsartan			OFFSIDES
54	Venlafaxine Hydrochloride			OFFSIDES
55	chlordiazepoxide, clidinium drug combination			OFFSIDES
56	glimepiride			OFFSIDES
57	metaxalone			OFFSIDES
58	olmesartan			OFFSIDES
59	ropinirole			OFFSIDES
60	tegaserod			SIDER
61	tizanidine			OFFSIDES
62	zaleplon			OFFSIDES
63	zopiclone			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Choledocholithiasis	32.4%
2	Cholangitis	28.5%
3	Cholestasis	28.5%
4	Cholelithiasis	22.7%
5	Bile Duct Neoplasms	18%
6	Cholestasis, Extrahepatic	16.8%
7	Cholangitis, Sclerosing	16.8%
8	Cholecystolithiasis	16.4%
9	Gastrointestinal Diseases	15.3%
10	Liver diseases	15.3%
11	Pancreatic Diseases	15.3%
12	Choledochal Cyst	14.9%
13	Cholecystitis	12.2%
14	gallbladder neoplasm	11.5%
15	Digestive System Neoplasms	10.2%
16	Biliary cirrhosis	9.8%
17	Gastrointestinal Neoplasms	7.7%
18	Liver neoplasms	7.7%
19	Pancreatic Fistula	7.6%
20	Chylous Ascites	7.6%
21	Esophageal Diseases	7.6%
22	Fatty Liver	7.6%
23	Gastroenteritis	7.6%
24	Hepatitis	7.6%
25	Portal Hypertension	7.6%
26	Intestinal Diseases	7.6%
27	Liver Cirrhosis	7.6%
28	Pancreatic Insufficiency	7.6%
29	Pancreatitis	7.6%
30	Pneumoperitoneum	7.6%
31	Stomach Diseases	7.6%
32	Focal Nodular Hyperplasia	7.6%
33	Hepatic Insufficiency	7.6%
34	Steatohepatitis	7.6%
35	Acalculous Cholecystitis	7.2%
36	Peritoneal Neoplasms	6.1%
37	Mesenteric vascular insufficiency	6%
38	Esophageal Atresia	5.9%
39	Intestinal Atresia	5.9%
40	Mesenteric Vascular Occlusion	5.9%
41	Intestinal Fistula	5.8%
42	Enterocutaneous Fistula	5.8%
43	Dysentery	5.5%
44	Enteritis	5.5%
45	Enterocolitis	5.5%
46	Esophageal and Gastric Varices	5.5%
47	Esophagitis	5.5%
48	Gastritis	5.5%
49	Inflammatory Bowel Diseases	5.5%
50	Liver Diseases, Parasitic	5.4%
51	Hepatic Veno-Occlusive Disease	5.1%
52	Pancreatic Cyst	5.1%
53	Peliosis Hepatis	5.1%
54	Hepatopulmonary Syndrome	5.1%
55	Pancreatic Neoplasm	5.1%
56	Zollinger-Ellison syndrome	5.1%
57	Anus, Imperforate	5%
58	Gastrointestinal Hemorrhage	5%
59	Hemoperitoneum	5%
60	Hepatomegaly	5%
61	Mesenteric Panniculitis	5%
62	Panniculitis, Peritoneal	5%
63	Peritonitis	5%
64	Peritoneal Fibrosis	5%
65	Encapsulating Peritoneal Sclerosis	5%
66	Anorectal Malformations	5%
67	Biliary Fistula	5%
68	Gastric Fistula	5%
69	Hepatic Vein Thrombosis	4.9%
70	Liver Abscess	4.9%
71	Budd-Chiari Syndrome	4.9%
72	Tuberculosis, Gastrointestinal	4.9%
73	Intestinal Neoplasms	4.9%
74	Stomach Neoplasms	4.9%
75	Emphysematous Cholecystitis	4.8%
76	Colitis	4.3%
77	Duodenogastric Reflux	4.3%
78	Peptic Ulcer	4.3%
79	Proctitis	4.3%
80	Esophageal Neoplasms	4.1%
81	Gastrointestinal Stromal Tumors	4.1%
82	Cecal Diseases	4.1%
83	Colonic Diseases	4.1%
84	Esophageal Stenosis	4.1%
85	Fatty Liver, Alcoholic	4.1%
86	Hepatitis, Alcoholic	4.1%
87	Hepatitis, Chronic	4.1%
88	Ileal Diseases	4.1%
89	Intestinal Obstruction	4.1%
90	Intestinal Perforation	4.1%
91	Jejunal Diseases	4.1%
92	Liver Cirrhosis, Alcoholic	4.1%
93	Pneumatosis Cystoides Intestinalis	4.1%
94	Rectal Diseases	4.1%
95	Gastric Dilatation	4.1%
96	Liver Failure	4.1%
97	Pancreatitis, Chronic	4.1%
98	Gastric outlet obstruction	4.1%
99	Cronkhite-Canada Syndrome	4.1%
100	Non-alcoholic Fatty Liver Disease	4.1%
101	Chronic active hepatitis	4.1%
102	Intestinal Polyposis	4.1%
103	Chemical and Drug Induced Liver Injury	3.9%
104	Hepatorenal Syndrome	3.7%
105	Duodenitis	3.6%
106	Ileitis	3.6%
107	Erosive Duodenitis	3.6%
108	Rectal Fistula	3.5%
109	Anal Fistula	3.5%
110	Colorectal Neoplasms	3.4%
111	Appendicitis	3.3%
112	Hepatocellular Adenoma	3.3%
113	Cecal Neoplasms	3.2%
114	Crohn Disease	3.2%
115	Duodenal Neoplasms	3.2%
116	Duodenal Obstruction	3.2%
117	Enterocolitis, Neutropenic	3.2%
118	Necrotizing Enterocolitis	3.2%
119	Proctocolitis	3.2%
120	Cystic Fibrosis	3.1%
121	Porphyrias, Hepatic	3%
122	Congenital Hyperinsulinism	3%
123	Esophageal Perforation	2.9%
124	Hepatitis, Animal	2.9%
125	Hepatitis, Viral, Human	2.9%
126	Intestinal Diseases, Parasitic	2.9%
127	Barrett Esophagus	2.8%
128	Deglutition Disorders	2.8%
129	Liver Abscess, Amebic	2.8%
130	Liver Neoplasms, Experimental	2.8%
131	Achlorhydria	2.7%
132	Liver Cirrhosis, Experimental	2.7%
133	Pancreatic Pseudocyst	2.7%
134	Gastric Antral Vascular Ectasia	2.7%
135	Peptic Ulcer Hemorrhage	2.7%
136	Gastroparesis	2.7%
137	Pancreatitis, Alcoholic	2.7%
138	Duodenal Ulcer	2.7%
139	Peptic Ulcer Perforation	2.7%
140	Gastric ulcer	2.7%
141	Enterocolitis, Pseudomembranous	2.4%
142	pseudomembranous colitis	2.4%
143	Dysentery, Bacillary	2.4%
144	Colonic Diseases, Functional	2.4%
145	Esophageal motility disorders	2.4%
146	Fecal Incontinence	2.4%
147	Fecal Impaction	2.4%
148	Intussusception	2.4%
149	Mallory-Weiss Syndrome	2.4%
150	Megacolon	2.4%
151	Pyloric Stenosis	2.4%
152	Liver Failure, Acute	2.4%
153	End Stage Liver Disease	2.4%
154	Ileus	2.4%
155	Meconium ileus	2.4%
156	Pouchitis	2.4%
157	Appendiceal Neoplasms	2.1%
158	Colonic Neoplasms	2.1%
159	Rectal Neoplasms	2.1%
160	Fascioliasis	2.1%
161	Echinococcosis, Hepatic	2.1%
162	Melena	2.1%
163	Chemical and Drug Induced Liver Injury, Chronic	2.1%
164	Colitis, Ischemic	2%
165	Reye Syndrome	2%
166	Carcinoma, Pancreatic Ductal	2%
167	Hematemesis	2%
168	Colonic Pseudo-Obstruction	1.8%
169	Anus Neoplasms	1.8%
170	Sigmoid Neoplasms	1.8%
171	Adenomatous Polyposis Coli	1.8%
172	Hemorrhoids	1.7%
173	Autoimmune hepatitis	1.7%
174	Afferent Loop Syndrome	1.6%
175	Celiac Disease	1.6%
176	Short Bowel Syndrome	1.6%
177	Sprue, Tropical	1.6%
178	Steatorrhea	1.6%
179	Rectocele	1.6%
180	Sprue	1.6%
181	Nesidioblastosis	1.6%
182	Variegate Porphyria	1.6%
183	Acute intermittent porphyria	1.6%
184	Porphyria Cutanea Tarda	1.6%
185	Hepatitis B, Chronic	1.6%
186	Hepatitis C, Chronic	1.6%
187	Diverticulitis	1.6%
188	Dumping Syndrome	1.6%
189	Rectal Prolapse	1.6%
190	Massive Hepatic Necrosis	1.6%
191	Esophageal Achalasia	1.6%
192	Anal Fissure	1.6%
193	Intestinal Pseudo-Obstruction	1.6%
194	Irritable Bowel Syndrome	1.6%
195	Superior Mesenteric Artery Syndrome	1.6%
196	Neurogenic Bowel	1.6%
197	Anal Ulcer	1.6%
198	insulinoma	1.4%
199	Gastrinoma	1.4%
200	Glucagonoma	1.4%
201	Zellweger Syndrome	1.3%
202	Hepatitis, Viral, Animal	1.3%
203	Giardiasis	1.3%
204	Hepatitis E	1.3%
205	Hepatitis B	1.2%
206	Hepatitis C	1.2%
207	Diverticulum	1.2%
208	Hepatitis A	1.2%
209	Diverticulosis	1.2%
210	Hepatolenticular Degeneration	1.2%
211	Hepatic Encephalopathy	1.2%
212	Vipoma	1.2%
213	Pruritus Ani	1.1%
214	Peutz-Jeghers Syndrome	1%
215	Lactose Intolerance	1%
216	Laryngopharyngeal Reflux	0.8%
217	Cryptosporidiosis	0.7%
218	Rift Valley Fever	0.5%
219	CREST Syndrome	0.5%

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