MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pneumoperitoneum

(UMLS:C0032320)

Definition:: A condition with trapped gas or air in the PERITONEAL CAVITY, usually secondary to perforation of the internal organs such as the LUNG and the GASTROINTESTINAL TRACT, or to recent surgery. Pneumoperitoneum may be purposely introduced to aid radiological examination.
UMLS ID:: C0032320
MeSH ID:: D011027

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.844.670

Synonym(s)

Pneumoperitoneum

Free air in abdomen

Free air in peritoneal cavity

PNEUMOPERITONEUM

PP - Pneumoperitoneum

Peritoneal cavity free air

Pneumoabdomen

pneumoperitoneum

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	carbidopa, levodopa drug combination	FAERS: 42 Canada Vigilance: 1		Canada Vigilance US FAERS
2	rofecoxib	FAERS: 10		US FAERS
3	Metformin	FAERS: 9		US FAERS
4	Sorafenib	FAERS: 9		US FAERS
5	Ibuprofen	FAERS: 8		US FAERS
6	Paclitaxel	FAERS: 7		US FAERS
7	Acarbose	FAERS: 6		SIDER US FAERS
8	pazopanib	FAERS: 5		US FAERS
9	Bortezomib	FAERS: 4		OFFSIDES US FAERS
10	Clozapine	FAERS: 4		US FAERS
11	Dabigatran	FAERS: 4		US FAERS
12	Deferasirox	FAERS: 4		OFFSIDES US FAERS
13	Sunitinib	FAERS: 4		US FAERS
14	Carbon Dioxide	FAERS: 3		US FAERS
15	Indomethacin	FAERS: 3		US FAERS
16	Methylprednisolone	FAERS: 3 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
17	NuvaRing	FAERS: 3		OFFSIDES US FAERS
18	Prednisolone	FAERS: 3		US FAERS
19	regorafenib	FAERS: 3		US FAERS
20	Arthrotec	FAERS: 2		US FAERS
21	Baclofen	FAERS: 2		US FAERS
22	Barium	FAERS: 2		US FAERS
23	Buprenorphine	FAERS: 2		US FAERS
24	Dexamethasone	FAERS: 2		OFFSIDES US FAERS
25	Diclofenac	FAERS: 2		US FAERS
26	Erlotinib Hydrochloride	FAERS: 2		US FAERS
27	Oxygen	FAERS: 2		US FAERS
28	Oxymorphone	FAERS: 2		US FAERS
29	Propofol	FAERS: 2		US FAERS
30	Rivaroxaban	FAERS: 2		US FAERS
31	Sunitinib	FAERS: 2		OFFSIDES US FAERS
32	tegaserod	FAERS: 2		US FAERS
33	Acarbose	FAERS: 1		US FAERS
34	Amiodarone	FAERS: 1		US FAERS
35	Anidulafungin	FAERS: 1		US FAERS
36	Bisacodyl	FAERS: 1		OFFSIDES US FAERS
37	Bupivacaine	FAERS: 1		US FAERS
38	CH5424802	FAERS: 1		US FAERS
39	Ciprofloxacin	FAERS: 1		US FAERS
40	Dobutamine	FAERS: 1		US FAERS
41	Epoprostenol	FAERS: 1		US FAERS
42	Erlotinib Hydrochloride	FAERS: 1		US FAERS
43	Fingolimod Hydrochloride	FAERS: 1		US FAERS
44	Fluorouracil	FAERS: 1		US FAERS
45	Gabapentin	FAERS: 1		US FAERS
46	Gefitinib	FAERS: 1		US FAERS
47	Hydrocortisone	FAERS: 1		US FAERS
48	Hydroxychloroquine	FAERS: 1		US FAERS
49	Imatinib Mesylate	FAERS: 1		US FAERS
50	Imatinib Mesylate	FAERS: 1		US FAERS
51	Lactulose	FAERS: 1		OFFSIDES US FAERS
52	Metronidazole	FAERS: 1		OFFSIDES US FAERS
53	Naltrexone	FAERS: 1		US FAERS
54	Nitrogen	FAERS: 1		US FAERS
55	Norgestrel	FAERS: 1		US FAERS
56	Oxycodone	FAERS: 1		US FAERS
57	Paroxetine	FAERS: 1		US FAERS
58	Pemetrexed	FAERS: 1		US FAERS
59	Rosuvastatin Calcium	FAERS: 1		US FAERS
60	Ruxolitinib phosphate	FAERS: 1		US FAERS
61	Sitagliptin Phosphate	FAERS: 1		OFFSIDES US FAERS
62	Tacrolimus	FAERS: 1		US FAERS
63	Tadalafil	FAERS: 1		OFFSIDES US FAERS
64	acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide	FAERS: 1		US FAERS
65	cabozantinib	FAERS: 1		US FAERS
66	elbasvir-grazoprevir drug combination	FAERS: 1		US FAERS
67	gemcitabine	FAERS: 1		US FAERS
68	isosorbide-5-mononitrate	FAERS: 1		US FAERS
69	niraparib	FAERS: 1		US FAERS
70	pazopanib	FAERS: 1		US FAERS
71	prednisolone phosphate	FAERS: 1		US FAERS
72	reviparin	FAERS: 1		US FAERS
73	Acetyldigoxins			OFFSIDES
74	Amoxicillin			OFFSIDES
75	Atracurium			OFFSIDES
76	Cefotaxime			OFFSIDES
77	Ceftriaxone			OFFSIDES
78	Clotrimazole			OFFSIDES
79	Cocaine		15005948	CTD
80	Cytarabine			OFFSIDES
81	Daunorubicin			OFFSIDES
82	Diflunisal			OFFSIDES
83	Flurazepam			OFFSIDES
84	Isradipine			OFFSIDES
85	Leucovorin			OFFSIDES
86	Medroxyprogesterone Acetate			OFFSIDES
87	Medroxyprogesterone			OFFSIDES
88	Mercaptopurine			OFFSIDES
89	Methylprednisolone Hemisuccinate			OFFSIDES
90	Methyltestosterone			OFFSIDES
91	Metolazone			OFFSIDES
92	Nafronyl			OFFSIDES
93	Potassium Acetate			OFFSIDES
94	Prazepam			OFFSIDES
95	Rabeprazole			OFFSIDES
96	Simethicone			OFFSIDES
97	Sumatriptan			OFFSIDES
98	Temozolomide			OFFSIDES
99	Thalidomide	Canada Vigilance: 1		Canada Vigilance
100	Ticarcillin			OFFSIDES
101	Tretinoin			OFFSIDES
102	Verapamil			OFFSIDES
103	Vinorelbine			OFFSIDES
104	Zidovudine			OFFSIDES
105	buflomedil			OFFSIDES
106	cefuroxime axetil			OFFSIDES
107	desloratadine			OFFSIDES
108	dihydrocodeine			OFFSIDES
109	ixabepilone			OFFSIDES
110	miglitol			SIDER
111	nefazodone			OFFSIDES
112	repaglinide			OFFSIDES
113	rizatriptan			OFFSIDES
114	tizanidine			OFFSIDES
115	trandolapril			OFFSIDES
116	voglibose			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Chylous Ascites	42.9%
2	Hemoperitoneum	27.9%
3	Mesenteric Panniculitis	27.9%
4	Panniculitis, Peritoneal	27.9%
5	Peritonitis	27.9%
6	Peritoneal Fibrosis	27.9%
7	Encapsulating Peritoneal Sclerosis	27.9%
8	Mesenteric vascular insufficiency	26.3%
9	Mesenteric Vascular Occlusion	25.9%
10	Biliary Tract Diseases	23.1%
11	Gastrointestinal Diseases	23.1%
12	Liver diseases	23.1%
13	Pancreatic Diseases	23.1%
14	Peritoneal Neoplasms	22.2%
15	Digestive System Neoplasms	15%
16	Bile Duct Diseases	14.3%
17	Cholelithiasis	14.3%
18	Esophageal Diseases	14.3%
19	Fatty Liver	14.3%
20	Gastroenteritis	14.3%
21	Hepatitis	14.3%
22	Portal Hypertension	14.3%
23	Intestinal Diseases	14.3%
24	Liver Cirrhosis	14.3%
25	Pancreatic Insufficiency	14.3%
26	Pancreatitis	14.3%
27	Stomach Diseases	14.3%
28	Focal Nodular Hyperplasia	14.3%
29	Hepatic Insufficiency	14.3%
30	Steatohepatitis	14.3%
31	Gastrointestinal Neoplasms	14%
32	Liver neoplasms	14%
33	Zollinger-Ellison syndrome	13.9%
34	Pancreatic Fistula	13.9%
35	Biliary cirrhosis	13.8%
36	Dysentery	13.6%
37	Enteritis	13.6%
38	Enterocolitis	13.6%
39	Esophageal and Gastric Varices	13.6%
40	Esophagitis	13.6%
41	Gastritis	13.6%
42	Inflammatory Bowel Diseases	13.6%
43	Cholecystolithiasis	13.6%
44	Proctocolitis	12.7%
45	Duodenitis	12.4%
46	Ileitis	12.4%
47	Erosive Duodenitis	12.4%
48	Colitis	12.4%
49	Duodenogastric Reflux	12.4%
50	Peptic Ulcer	12.4%
51	Proctitis	12.4%
52	Choledocholithiasis	12.4%
53	Bile Duct Neoplasms	12.1%
54	gallbladder neoplasm	12.1%
55	Intestinal Neoplasms	12.1%
56	Stomach Neoplasms	12.1%
57	Esophageal Atresia	12.1%
58	Intestinal Atresia	12.1%
59	Intestinal Fistula	12%
60	Enterocutaneous Fistula	12%
61	Colorectal Neoplasms	11.7%
62	Crohn Disease	11.1%
63	Duodenal Obstruction	11.1%
64	Enterocolitis, Neutropenic	11.1%
65	Necrotizing Enterocolitis	11.1%
66	Pouchitis	11%
67	Cecal Neoplasms	10.9%
68	Duodenal Neoplasms	10.9%
69	Rectal Fistula	10.6%
70	Anal Fistula	10.6%
71	Duodenal Ulcer	10.5%
72	Peptic Ulcer Perforation	10.5%
73	Gastric ulcer	10.5%
74	Cecal Diseases	10.3%
75	Cholangitis	10.3%
76	Cholecystitis	10.3%
77	Cholestasis	10.3%
78	Colonic Diseases	10.3%
79	Common Bile Duct Diseases	10.3%
80	Esophageal Stenosis	10.3%
81	Hepatitis, Chronic	10.3%
82	Ileal Diseases	10.3%
83	Intestinal Obstruction	10.3%
84	Intestinal Perforation	10.3%
85	Jejunal Diseases	10.3%
86	Pneumatosis Cystoides Intestinalis	10.3%
87	Rectal Diseases	10.3%
88	Gastric Dilatation	10.3%
89	Liver Failure	10.3%
90	Pancreatitis, Chronic	10.3%
91	Gastric outlet obstruction	10.3%
92	Cronkhite-Canada Syndrome	10.3%
93	Non-alcoholic Fatty Liver Disease	10.3%
94	Chronic active hepatitis	10.3%
95	Intestinal Polyposis	10.3%
96	Gastrointestinal Stromal Tumors	10.1%
97	Esophageal Neoplasms	10.1%
98	Fatty Liver, Alcoholic	10%
99	Hepatitis, Alcoholic	10%
100	Liver Cirrhosis, Alcoholic	10%
101	Liver Diseases, Parasitic	10%
102	Anus Neoplasms	9.8%
103	Sigmoid Neoplasms	9.8%
104	Choledochal Cyst	9.7%
105	Appendiceal Neoplasms	9.7%
106	Colonic Neoplasms	9.7%
107	Rectal Neoplasms	9.7%
108	Colonic Pseudo-Obstruction	9.6%
109	Hepatic Veno-Occlusive Disease	9.5%
110	Pancreatic Cyst	9.5%
111	Peliosis Hepatis	9.5%
112	Hepatopulmonary Syndrome	9.5%
113	Anus, Imperforate	9.3%
114	Gastrointestinal Hemorrhage	9.3%
115	Hepatomegaly	9.3%
116	Pancreatic Neoplasm	9.3%
117	Anorectal Malformations	9.3%
118	Appendicitis	9.2%
119	Biliary Fistula	9.2%
120	Gastric Fistula	9.2%
121	Hepatic Vein Thrombosis	9.1%
122	Liver Abscess	9.1%
123	Budd-Chiari Syndrome	9.1%
124	Tuberculosis, Gastrointestinal	9.1%
125	Cholestasis, Extrahepatic	8.5%
126	Biliary Dyskinesia	8.5%
127	Cholangitis, Sclerosing	8.5%
128	Colonic Diseases, Functional	8.5%
129	Esophageal motility disorders	8.5%
130	Fecal Incontinence	8.5%
131	Fecal Impaction	8.5%
132	Intussusception	8.5%
133	Mallory-Weiss Syndrome	8.5%
134	Megacolon	8.5%
135	Pyloric Stenosis	8.5%
136	Liver Failure, Acute	8.5%
137	Acalculous Cholecystitis	8.5%
138	End Stage Liver Disease	8.5%
139	Ileus	8.5%
140	Meconium ileus	8.5%
141	Enterocolitis, Pseudomembranous	8.3%
142	pseudomembranous colitis	8.3%
143	Dysentery, Bacillary	8.3%
144	Colitis, Ischemic	8%
145	Hepatocellular Adenoma	8%
146	Massive Hepatic Necrosis	7.6%
147	Esophageal Achalasia	7.6%
148	Anal Fissure	7.6%
149	Intestinal Pseudo-Obstruction	7.6%
150	Irritable Bowel Syndrome	7.6%
151	Superior Mesenteric Artery Syndrome	7.6%
152	Emphysematous Cholecystitis	7.6%
153	Neurogenic Bowel	7.6%
154	Sphincter of Oddi Dysfunction	7.6%
155	Anal Ulcer	7.6%
156	Adenomatous Polyposis Coli	7.5%
157	Esophageal Perforation	7.3%
158	Hepatitis, Animal	7.3%
159	Hepatitis, Viral, Human	7.3%
160	Intestinal Diseases, Parasitic	7.3%
161	Chemical and Drug Induced Liver Injury	7.1%
162	Barrett Esophagus	7%
163	Deglutition Disorders	7%
164	Hepatorenal Syndrome	6.8%
165	Achlorhydria	6.8%
166	Liver Cirrhosis, Experimental	6.8%
167	Pancreatic Pseudocyst	6.8%
168	Gastric Antral Vascular Ectasia	6.8%
169	Liver Abscess, Amebic	6.8%
170	Liver Neoplasms, Experimental	6.7%
171	Peptic Ulcer Hemorrhage	6.7%
172	Gastroparesis	6.7%
173	Pancreatitis, Alcoholic	6.7%
174	Hepatitis B, Chronic	6.3%
175	Hepatitis C, Chronic	6.3%
176	Hemorrhoids	5.7%
177	Autoimmune hepatitis	5.7%
178	Cystic Fibrosis	5.7%
179	Afferent Loop Syndrome	5.6%
180	Celiac Disease	5.6%
181	Short Bowel Syndrome	5.6%
182	Sprue, Tropical	5.6%
183	Steatorrhea	5.6%
184	Rectocele	5.6%
185	Sprue	5.6%
186	Diverticulitis	5.6%
187	Dumping Syndrome	5.6%
188	Rectal Prolapse	5.6%
189	Porphyrias, Hepatic	5.5%
190	Congenital Hyperinsulinism	5.5%
191	Fascioliasis	5.2%
192	Echinococcosis, Hepatic	5.1%
193	Melena	5.1%
194	Chemical and Drug Induced Liver Injury, Chronic	5.1%
195	Reye Syndrome	5%
196	Pruritus Ani	5%
197	Hematemesis	5%
198	Carcinoma, Pancreatic Ductal	4.9%
199	Laryngopharyngeal Reflux	4.8%
200	insulinoma	4.6%
201	Gastrinoma	4.6%
202	Glucagonoma	4.6%
203	Hepatitis, Viral, Animal	4.5%
204	Giardiasis	4.3%
205	Hepatitis E	4.3%
206	Hepatitis B	4.3%
207	Hepatitis C	4.3%
208	Diverticulum	4.2%
209	Hepatitis A	4.2%
210	Diverticulosis	4.2%
211	Hepatic Encephalopathy	4.2%
212	Vipoma	4%
213	Nesidioblastosis	4%
214	Variegate Porphyria	4%
215	Acute intermittent porphyria	4%
216	Porphyria Cutanea Tarda	4%
217	Peutz-Jeghers Syndrome	3.4%
218	Lactose Intolerance	3.3%
219	Cryptosporidiosis	2.4%
220	Zellweger Syndrome	2.4%
221	Hepatolenticular Degeneration	2.2%
222	Rift Valley Fever	2.2%
223	CREST Syndrome	2.1%

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