MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Gastrinoma

(UMLS:C0017150)

Definition:: A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).
UMLS ID:: C0017150
MeSH ID:: D015408

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.025.290.500|C04.588.274.761.500.124|C04.588.322.475.500.124

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.301.761.500.124|C06.689.667.500.124

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.344.421.500.124

Synonym(s)

Gastrinoma

G Cell Tumor

G cell tumor

G cell tumor, NOS

G cell tumour

G cell tumour, NOS

G cell; tumor, unspecified site

G-Cell Gastrin Producing Tumor

G-Cell Tumor

10.

Gastrin Secreting Tumor

11.

Gastrin cell tumor

12.

Gastrin-Producing NET

13.

Gastrin-Producing Neuroendocrine Tumor

14.

Gastrinoma NOS

15.

Gastrinoma, NOS

16.

[M]Gastrinoma NOS

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Octreotide	FAERS: 3	US FAERS
2	Omeprazole	FAERS: 3	US FAERS
3	Diclofenac	FAERS: 1	US FAERS
4	Everolimus	FAERS: 1	US FAERS
5	Metoclopramide	FAERS: 1	US FAERS
6	Pamidronate	FAERS: 1	US FAERS
7	Sitagliptin Phosphate	FAERS: 1	US FAERS
8	miglustat	FAERS: 1	US FAERS
9	rofecoxib	FAERS: 1	US FAERS
10	Amlodipine		OFFSIDES
11	Carticaine		OFFSIDES
12	Flurazepam		OFFSIDES
13	Glycopyrrolate		OFFSIDES
14	Hydralazine		OFFSIDES
15	Hydroxyurea		OFFSIDES
16	Hydroxyzine		OFFSIDES
17	Ketorolac Tromethamine		OFFSIDES
18	Lisinopril		OFFSIDES
19	Minocycline		OFFSIDES
20	Octreotide		OFFSIDES
21	Omeprazole		SIDER
22	Pamidronate		OFFSIDES
23	Sevelamer		OFFSIDES
24	Tigecycline		OFFSIDES
25	eprosartan		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Glucagonoma	52.3%
2	Vipoma	45.1%
3	Carcinoma, Pancreatic Ductal	37.2%
4	Peritoneal Neoplasms	24.5%
5	insulinoma	24.2%
6	Parathyroid Neoplasms	21.2%
7	Thyroid Neoplasm	21.2%
8	Thyroid carcinoma	21.2%
9	Gastrointestinal Neoplasms	20.9%
10	Liver neoplasms	20.9%
11	Multiple Endocrine Neoplasia	20.7%
12	Carcinoma, Lobular	17.4%
13	Adrenal Gland Neoplasms	17.3%
14	Esophageal Neoplasms	17%
15	Testicular Neoplasms	15.1%
16	Hepatocellular Adenoma	14.9%
17	Cystadenocarcinoma	14.8%
18	Mucoepidermoid Carcinoma	14.8%
19	Abdominal Neoplasms	14.5%
20	Head and Neck Neoplasms	14.5%
21	Soft Tissue Neoplasms	14.5%
22	Thoracic Neoplasms	14.5%
23	Carcinoma, Ehrlich Tumor	14.2%
24	Carcinoma, Lewis Lung	14.2%
25	Liver Neoplasms, Experimental	14.1%
26	Pancreatic Cyst	13.6%
27	Basal cell carcinoma	13.4%
28	Carcinoma, Papillary	13.4%
29	Squamous cell carcinoma	13.4%
30	Carcinoma, Basal Cell	13.4%
31	Adrenocortical carcinoma	13.4%
32	ovarian neoplasm	13.4%
33	Carcinoma, Ovarian Epithelial	13.1%
34	Bile Duct Neoplasms	13%
35	gallbladder neoplasm	13%
36	Intestinal Neoplasms	13%
37	Stomach Neoplasms	13%
38	Eye Neoplasms	13%
39	Nervous System Neoplasms	13%
40	Bone neoplasms	12.8%
41	Skin Neoplasms	12.8%
42	Hematologic Neoplasms	12.8%
43	Splenic Neoplasms	12.7%
44	Choriocarcinoma	12.6%
45	Thyroid Nodule	12.4%
46	Neoplasms, Neuroepithelial	12.2%
47	Gliomatosis cerebri	12.2%
48	Carcinoid Tumor	12%
49	Hamartoma	11.9%
50	Neoplasms, Hormone-Dependent	11.9%
51	Neoplasms, Multiple Primary	11.9%
52	Paraneoplastic Syndromes	11.9%
53	Precancerous Conditions	11.9%
54	Neoplasms, Second Primary	11.9%
55	Pituitary Adenoma	11.9%
56	Pituitary Neoplasms	11.9%
57	Prolactinoma	11.7%
58	Growth Hormone-Secreting Pituitary Adenoma	11.7%
59	Multiple Endocrine Neoplasia Type 1	11.7%
60	Acanthoma	11.7%
61	Adenoid Cystic Carcinoma	11.5%
62	Adenocarcinoma, Clear Cell	11.5%
63	Cholangiocarcinoma	11.5%
64	Digestive System Neoplasms	11.2%
65	Paraneoplastic Encephalomyelitis	11.1%
66	Zollinger-Ellison syndrome	11.1%
67	Mammary Neoplasms, Experimental	11%
68	Pancreatic Fistula	10.9%
69	Cyst	10.5%
70	Neoplastic Processes	10.5%
71	Neoplastic Syndromes, Hereditary	10.5%
72	Pregnancy Complications, Neoplastic	10.5%
73	Neoplasms, Experimental	10.4%
74	Adenomatous Polyposis Coli	10.2%
75	leukemia	10.1%
76	Neoplasms, Germ Cell and Embryonal	10.1%
77	Germ Cell Cancer	10.1%
78	Carcinoma in Situ	9.9%
79	Carcinoma, Transitional Cell	9.9%
80	Carcinoma, Large Cell	9.9%
81	Carcinoma, Small Cell	9.9%
82	Meningioma	9.8%
83	Choledochal Cyst	9.6%
84	Adenoma	9.5%
85	Neuroectodermal Tumors	9.5%
86	Cystadenoma	9.4%
87	Mesothelioma	9.4%
88	Neoplasms, Radiation-Induced	9.3%
89	Colorectal Neoplasms	9.3%
90	Pancreatic Insufficiency	9.3%
91	Pancreatitis	9.3%
92	granulosa cell tumor	9.1%
93	Trophoblastic Neoplasms	9.1%
94	Leukemia, Experimental	9%
95	Tracheal Neoplasms	9%
96	Cecal Neoplasms	9%
97	Duodenal Neoplasms	9%
98	Pancreatic Neoplasm	8.9%
99	Gastrointestinal Stromal Tumors	8.9%
100	Histiocytic Disorders, Malignant	8.9%
101	Tuberous Sclerosis	8.8%
102	Carcinoma 256, Walker	8.7%
103	Carcinoma, Endometrioid	8.6%
104	Renal Cell Carcinoma	8.5%
105	Papillary Renal Cell Carcinoma	8.5%
106	Biliary Tract Diseases	8.5%
107	Gastrointestinal Diseases	8.5%
108	Liver diseases	8.5%
109	Leukemia, Radiation-Induced	8.2%
110	Bowen's Disease	8.2%
111	Malignant Carcinoid Syndrome	8.1%
112	Dermoid Cyst	8.1%
113	Retroperitoneal Neoplasms	7.9%
114	Basal Cell Nevus Syndrome	7.9%
115	Thymoma	7.9%
116	Lymphoma	7.9%
117	Barrett Esophagus	7.8%
118	Pancreatic Pseudocyst	7.8%
119	Klatskin Tumor	7.7%
120	Melanoma, Experimental	7.6%
121	Retinoblastoma	7.6%
122	Composite Lymphoma	7.6%
123	Carcinosarcoma	7.4%
124	Hemangiosarcoma	7.4%
125	lymphangiosarcoma	7.4%
126	Endocrine Gland Neoplasms	7.4%
127	Nephroblastoma	7.3%
128	melanoma	7.2%
129	Sarcoma, Experimental	7.2%
130	Adenoma, Acidophil	7.2%
131	Ganglioneuroma	7.2%
132	Glioma	7.2%
133	Malignant Glioma	7.2%
134	Mouth Neoplasms	7%
135	Central Nervous System Neoplasms	7%
136	Vascular Neoplasms	7%
137	Thymus Neoplasms	7%
138	Medulloblastoma	7%
139	Genital Neoplasms, Female	7%
140	Breast Neoplasms, Male	6.9%
141	Triple Negative Breast Neoplasms	6.9%
142	Leydig Cell Tumor	6.7%
143	Cystic Fibrosis	6.7%
144	Appendiceal Neoplasms	6.7%
145	Colonic Neoplasms	6.7%
146	Rectal Neoplasms	6.7%
147	Leukemia, Plasma Cell	6.6%
148	Nasopharyngeal carcinoma	6.6%
149	Congenital Hyperinsulinism	6.5%
150	Genital Neoplasms, Male	6.3%
151	Uveal Neoplasms	6.3%
152	Urologic Neoplasms	6.3%
153	Sebaceous Gland Neoplasms	6.2%
154	Spinal Neoplasms	6.2%
155	Bone Marrow Neoplasms	6.2%
156	Erythroplasia	6.1%
157	Follicular cyst	6.1%
158	Mucocele	6.1%
159	Pilonidal Cyst	6.1%
160	Thyroglossal Cyst	6.1%
161	Synovial Cyst	6.1%
162	Aberrant Crypt Foci	6.1%
163	Cervical Intraepithelial Neoplasia	6%
164	Nelson Syndrome	6%
165	Adenofibroma	5.9%
166	Fibroadenoma	5.9%
167	Corpus Luteum Cyst	5.9%
168	Ovarian Cysts	5.9%
169	Anus Neoplasms	5.9%
170	Sigmoid Neoplasms	5.9%
171	Mesenteric vascular insufficiency	5.8%
172	Esophageal Atresia	5.8%
173	Intestinal Atresia	5.8%
174	Mesenteric Vascular Occlusion	5.8%
175	Intestinal Fistula	5.8%
176	Enterocutaneous Fistula	5.8%
177	Leukoplakia, Oral	5.7%
178	Carcinoid Heart Disease	5.7%
179	Paraneoplastic Cerebellar Degeneration	5.6%
180	Lymphomatoid Granulomatosis	5.6%
181	Leukemia L1210	5.6%
182	Leukemia P388	5.6%
183	Acoustic Neuroma	5.6%
184	Peutz-Jeghers Syndrome	5.6%
185	Pancreatitis, Chronic	5.5%
186	Leukoplakia	5.4%
187	Lymphocele	5.4%
188	Chondrosarcoma	5.4%
189	Craniopharyngioma	5.4%
190	leiomyosarcoma	5.4%
191	liposarcoma	5.4%
192	synovial sarcoma	5.4%
193	Neuroectodermal Tumor, Melanotic	5.4%
194	Angiomyolipoma	5.4%
195	Clear Cell Sarcoma of Soft Tissue	5.4%
196	Alveolar Soft Part Sarcoma	5.4%
197	Neuroendocrine Tumors	5.4%
198	Sarcoma, Myeloid	5.4%
199	Ameloblastoma	5.4%
200	Angiokeratoma	5.4%
201	Chordoma	5.4%
202	Hemangioma	5.4%
203	hemangiopericytoma	5.4%
204	Lymphangioma	5.4%
205	Mesenchymoma	5.4%
206	Nevus	5.4%
207	Teratoma	5.4%
208	Hepatoblastoma	5.4%
209	Mixed Tumor, Mullerian	5.4%
210	Germinoma	5.4%
211	Teratocarcinoma	5.4%
212	Angiofibroma	5.4%
213	Sarcoma	5.4%
214	Breast Cyst	5.4%
215	Actinic keratosis	5.4%
216	Mediastinal Cyst	5.4%
217	Neoplasm Invasiveness	5.4%
218	Neoplasm Metastasis	5.4%
219	Neoplasm Recurrence, Local	5.4%
220	Parovarian Cyst	5.4%
221	Pericardial Cyst	5.4%
222	Thymic Cyst	5.4%
223	Carcinogenesis	5.4%
224	Myxoid cyst	5.4%
225	Metastasis	5.4%
226	Biliary cirrhosis	5.4%
227	Papilloma	5.4%
228	Pseudomyxoma Peritonei	5.4%
229	Papillomatosis	5.4%
230	Adenomatosis, Pulmonary	5.4%
231	Adenomatous Polyps	5.4%
232	Nose Neoplasms	5.2%
233	Limbic Encephalitis	5.1%
234	Endometrial Stromal Sarcoma	5.1%
235	Optic Nerve Glioma	5%
236	Mesoblastic Nephroma	4.9%
237	Proctocolitis	4.9%
238	Dysentery	4.8%
239	Enteritis	4.8%
240	Enterocolitis	4.8%
241	Esophageal and Gastric Varices	4.8%
242	Esophagitis	4.8%
243	Gastritis	4.8%
244	Inflammatory Bowel Diseases	4.8%
245	Cholecystolithiasis	4.8%
246	Pancreatitis, Alcoholic	4.8%
247	Lambert-Eaton Myasthenic Syndrome	4.8%
248	Plasmacytoma	4.7%
249	Malignant histiocytosis	4.7%
250	Histiocytic sarcoma	4.7%
251	Astrocytoma	4.7%
252	Ependymoma	4.7%
253	oligodendroglioma	4.7%
254	Ganglioglioma	4.7%
255	gliosarcoma	4.7%
256	Anaplastic astrocytoma	4.7%
257	Anaplastic Oligodendroglioma	4.7%
258	Bile Duct Diseases	4.6%
259	Cholelithiasis	4.6%
260	Chylous Ascites	4.6%
261	Esophageal Diseases	4.6%
262	Fatty Liver	4.6%
263	Gastroenteritis	4.6%
264	Hepatitis	4.6%
265	Portal Hypertension	4.6%
266	Intestinal Diseases	4.6%
267	Liver Cirrhosis	4.6%
268	Pneumoperitoneum	4.6%
269	Stomach Diseases	4.6%
270	Focal Nodular Hyperplasia	4.6%
271	Hepatic Insufficiency	4.6%
272	Steatohepatitis	4.6%
273	Sarcoma 180	4.6%
274	Palatal Neoplasms	4.6%
275	Neurilemmoma	4.5%
276	Hutchinson's Melanotic Freckle	4.5%
277	Melanoma, Amelanotic	4.5%
278	Rectal Fistula	4.5%
279	Anal Fistula	4.5%
280	Opsoclonus-Myoclonus Syndrome	4.4%
281	Fibrosarcoma	4.4%
282	Osteosarcoma	4.4%
283	Lymphangioleiomyomatosis	4.3%
284	Fatty Liver, Alcoholic	4.3%
285	Hepatitis, Alcoholic	4.3%
286	Liver Cirrhosis, Alcoholic	4.3%
287	Duodenitis	4.3%
288	Ileitis	4.3%
289	Erosive Duodenitis	4.3%
290	Adrenal Gland Diseases	4.3%
291	Gonadal Disorders	4.3%
292	Pancreatic Diseases	4.3%
293	Parathyroid Diseases	4.3%
294	Thyroid Diseases	4.3%
295	Hodgkin Disease	4.2%
296	Lymphoma, Non-Hodgkin	4.2%
297	Neoplasms, Glandular and Epithelial	4.2%
298	Liver Diseases, Parasitic	4.2%
299	Meningeal Neoplasms	4.1%
300	Hepatic Veno-Occlusive Disease	4.1%
301	Peliosis Hepatis	4.1%
302	Hepatopulmonary Syndrome	4.1%
303	Anus, Imperforate	4.1%
304	Gastrointestinal Hemorrhage	4.1%
305	Hemoperitoneum	4.1%
306	Hepatomegaly	4.1%
307	Mesenteric Panniculitis	4.1%
308	Panniculitis, Peritoneal	4.1%
309	Peritonitis	4.1%
310	Peritoneal Fibrosis	4.1%
311	Encapsulating Peritoneal Sclerosis	4.1%
312	Anorectal Malformations	4.1%
313	Myelitis, Transverse	4.1%
314	Biliary Fistula	4.1%
315	Gastric Fistula	4.1%
316	Hepatic Vein Thrombosis	4%
317	Liver Abscess	4%
318	Budd-Chiari Syndrome	4%
319	Tuberculosis, Gastrointestinal	4%
320	Colitis	4%
321	Duodenogastric Reflux	4%
322	Peptic Ulcer	4%
323	Proctitis	4%
324	Choledocholithiasis	4%
325	Malignant Fibrous Histiocytoma	3.9%
326	Nesidioblastosis	3.9%
327	Primary amyloidosis	3.8%
328	Bone Diseases, Endocrine	3.8%
329	Ear Neoplasms	3.7%
330	Eyelid Neoplasms	3.7%
331	Lung Neoplasms	3.7%
332	Pleural Neoplasms	3.7%
333	Denys-Drash Syndrome	3.7%
334	Diabetes Mellitus	3.7%
335	Pituitary Diseases	3.7%
336	Chemical and Drug Induced Liver Injury	3.7%
337	Brain Neoplasms	3.7%
338	Salivary Gland Neoplasms	3.7%
339	Spinal Cord Neoplasms	3.7%
340	Tongue Neoplasms	3.7%
341	Uterine Neoplasms	3.7%
342	Vaginal Neoplasms	3.7%
343	Vulvar Neoplasms	3.7%
344	Uterine Cancer	3.7%
345	Fallopian Tube Neoplasms	3.6%
346	Hepatorenal Syndrome	3.6%
347	Appendicitis	3.6%
348	Liver Abscess, Amebic	3.6%
349	Gastrinoma	3.5%
350	Glioblastoma	3.4%
351	Neuroblastoma	3.4%
352	Glioblastoma Multiforme	3.4%
353	Paraganglioma	3.4%
354	Rhabdomyosarcoma	3.4%
355	Giant Cell Tumor of Bone	3.4%
356	Pharyngeal Neoplasms	3.4%
357	Central Nervous System Cysts	3.3%
358	Dwarfism	3.3%
359	Neurofibrosarcoma	3.3%
360	Penile Neoplasms	3.3%
361	Prostatic Neoplasms	3.3%
362	Polycystic Ovary Syndrome	3.3%
363	Polycythemia Vera	3.3%
364	Porphyrias, Hepatic	3.3%
365	Crohn Disease	3.2%
366	Duodenal Obstruction	3.2%
367	Enterocolitis, Neutropenic	3.2%
368	Necrotizing Enterocolitis	3.2%
369	Pouchitis	3.2%
370	Waldenstrom Macroglobulinemia	3.2%
371	Multiple Myeloma	3.2%
372	Xeroderma Pigmentosum	3.1%
373	Laryngeal neoplasm	3.1%
374	Phyllodes Tumor	3.1%
375	Dysgerminoma	3.1%
376	Hemangioendothelioma	3.1%
377	Lipoma	3.1%
378	Myoma	3.1%
379	Myxoma	3.1%
380	Neuroma	3.1%
381	Seminoma	3.1%
382	Angiolipoma	3.1%
383	Myelolipoma	3.1%
384	Neoplasms, Bone Tissue	3.1%
385	Neoplasms, Fibrous Tissue	3.1%
386	Smooth Muscle Tumor	3.1%
387	Desmoplastic Small Round Cell Tumor	3.1%
388	Chondroma	3.1%
389	Enchondroma	3.1%
390	Hydatidiform Mole	3%
391	Bladder Neoplasm	3%
392	Kidney Neoplasm	3%
393	Ureteral Neoplasms	3%
394	Urethral Neoplasms	3%
395	Lymphatic Metastasis	2.9%
396	Neoplasms, Unknown Primary	2.9%
397	Leukemic Infiltration	2.9%
398	Neoplasm Micrometastasis	2.9%
399	Dermatofibrosarcoma	2.9%
400	Dermatofibrosarcoma Protuberans	2.9%
401	Enterocolitis, Pseudomembranous	2.8%
402	pseudomembranous colitis	2.8%
403	Dysentery, Bacillary	2.8%
404	Ganglioneuroblastoma	2.8%
405	Duodenal Ulcer	2.8%
406	Peptic Ulcer Perforation	2.8%
407	Gastric ulcer	2.8%
408	Cecal Diseases	2.8%
409	Cholangitis	2.8%
410	Cholecystitis	2.8%
411	Cholestasis	2.8%
412	Colonic Diseases	2.8%
413	Common Bile Duct Diseases	2.8%
414	Esophageal Stenosis	2.8%
415	Hepatitis, Chronic	2.8%
416	Ileal Diseases	2.8%
417	Intestinal Obstruction	2.8%
418	Intestinal Perforation	2.8%
419	Jejunal Diseases	2.8%
420	Pneumatosis Cystoides Intestinalis	2.8%
421	Rectal Diseases	2.8%
422	Gastric Dilatation	2.8%
423	Liver Failure	2.8%
424	Gastric outlet obstruction	2.8%
425	Cronkhite-Canada Syndrome	2.8%
426	Non-alcoholic Fatty Liver Disease	2.8%
427	Chronic active hepatitis	2.8%
428	Intestinal Polyposis	2.8%
429	Leukemia, Myelomonocytic, Chronic	2.7%
430	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.7%
431	Meningeal Carcinomatosis	2.7%
432	Colitis, Ischemic	2.5%
433	Esophageal Perforation	2.5%
434	Hepatitis, Animal	2.5%
435	Hepatitis, Viral, Human	2.5%
436	Intestinal Diseases, Parasitic	2.5%
437	Deglutition Disorders	2.4%
438	Mastocytosis	2.4%
439	Sturge-Weber Syndrome	2.4%
440	Bronchial Neoplasms	2.4%
441	Achlorhydria	2.4%
442	Liver Cirrhosis, Experimental	2.4%
443	Gastric Antral Vascular Ectasia	2.4%
444	Multiple Pulmonary Nodules	2.4%
445	Hemangioma, Cavernous	2.4%
446	Peptic Ulcer Hemorrhage	2.4%
447	Gastroparesis	2.4%
448	Leukemia, T-Cell	2.4%
449	Leukemia, B-Cell	2.4%
450	neurofibroma	2.4%
451	Supratentorial Neoplasms	2.4%
452	Lymphoma, Follicular	2.4%
453	T-Cell Lymphoma	2.4%
454	Mantle cell lymphoma	2.4%
455	Endometrial Neoplasms	2.4%
456	Pheochromocytoma	2.4%
457	Alveolar rhabdomyosarcoma	2.4%
458	Congenital Hypothyroidism	2.4%
459	Adrenal Cortex Diseases	2.3%
460	Euthyroid Sick Syndromes	2.3%
461	Goiter	2.3%
462	Hyperparathyroidism	2.3%
463	Hyperthyroidism	2.3%
464	Hyperthyroxinemia	2.3%
465	Hypogonadism	2.3%
466	Hypoparathyroidism	2.3%
467	Hypothyroidism	2.3%
468	Delayed Puberty	2.3%
469	Precocious Puberty	2.3%
470	Thyroiditis	2.3%
471	Hypogonadotropic hypogonadism	2.3%
472	Testotoxicosis	2.3%
473	Secondary hypothyroidism	2.3%
474	Primary Hyperthyroidism	2.3%
475	Primary Hypothyroidism	2.3%
476	Carcinoma	2.3%
477	Epithelioma	2.3%
478	Hepatitis B, Chronic	2.2%
479	Hepatitis C, Chronic	2.2%
480	Colonic Pseudo-Obstruction	2.2%
481	Hypopharyngeal Neoplasms	2.2%
482	Pleural Effusion, Malignant	2.2%
483	Hypopharyngeal Cancer	2.2%
484	Fascioliasis	2.2%
485	Echinococcosis, Hepatic	2.2%
486	Melena	2.2%
487	Parotid Neoplasms	2.2%
488	Prostatic Neoplasms, Castration-Resistant	2.2%
489	Chemical and Drug Induced Liver Injury, Chronic	2.2%
490	Reye Syndrome	2.2%
491	Hematemesis	2.1%
492	Testicular Diseases	2.1%
493	Zellweger Syndrome	2%
494	Ovarian Diseases	2%
495	Empty Sella Syndrome	2%
496	Hyperpituitarism	2%
497	Hypopituitarism	2%
498	Hypophysitis	2%
499	Graves Disease	2%
500	fibroma	1.9%
501	Fibromatosis	1.9%
502	Osteoblastoma	1.9%
503	Osteoma	1.9%
504	Rhabdomyoma	1.9%
505	Chondromatosis	1.9%
506	Hemangioblastoma	1.9%
507	Lymphoma, Extranodal NK-T-Cell	1.9%
508	Variegate Porphyria	1.9%
509	Acute intermittent porphyria	1.9%
510	Porphyria Cutanea Tarda	1.9%
511	Hepatolenticular Degeneration	1.9%
512	Cholestasis, Extrahepatic	1.8%
513	Biliary Dyskinesia	1.8%
514	Cholangitis, Sclerosing	1.8%
515	Colonic Diseases, Functional	1.8%
516	Esophageal motility disorders	1.8%
517	Fecal Incontinence	1.8%
518	Fecal Impaction	1.8%
519	Intussusception	1.8%
520	Mallory-Weiss Syndrome	1.8%
521	Megacolon	1.8%
522	Pyloric Stenosis	1.8%
523	Liver Failure, Acute	1.8%
524	Acalculous Cholecystitis	1.8%
525	End Stage Liver Disease	1.8%
526	Ileus	1.8%
527	Meconium ileus	1.8%
528	Nasopharyngeal Neoplasms	1.8%
529	Gestational Diabetes	1.8%
530	Latent Autoimmune Diabetes in Adults	1.8%
531	Diabetes Insipidus	1.8%
532	Diabetes Mellitus, Experimental	1.8%
533	Brain Stem Neoplasms	1.8%
534	Mastocytoma	1.7%
535	Mastocytosis, Systemic	1.7%
536	Leukemia, Myeloid, Chronic-Phase	1.7%
537	Paranasal Sinus Neoplasms	1.7%
538	Hermaphroditism	1.6%
539	Disorders of Sex Development	1.6%
540	Hemorrhoids	1.6%
541	Autoimmune hepatitis	1.6%
542	Pituitary Apoplexy	1.6%
543	Afferent Loop Syndrome	1.6%
544	Celiac Disease	1.6%
545	Short Bowel Syndrome	1.6%
546	Sprue, Tropical	1.6%
547	Steatorrhea	1.6%
548	Rectocele	1.6%
549	Sprue	1.6%
550	Diverticulitis	1.6%
551	Dumping Syndrome	1.6%
552	Rectal Prolapse	1.6%
553	Tonsillar Neoplasms	1.6%
554	Cerebellar Neoplasms	1.6%
555	Cell Transformation, Viral	1.5%
556	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.5%
557	Leukemia, Large Granular Lymphocytic	1.5%
558	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.5%
559	Lymphoma, T-Cell, Cutaneous	1.5%
560	Lymphoma, AIDS-Related	1.5%
561	Enteropathy-Associated T-Cell Lymphoma	1.5%
562	Primary Effusion Lymphoma	1.5%
563	Hepatitis, Viral, Animal	1.5%
564	Choroid Plexus Papilloma	1.5%
565	Giardiasis	1.5%
566	Hepatitis E	1.5%
567	Hepatitis B	1.4%
568	Hepatitis C	1.4%
569	Diverticulum	1.4%
570	Hepatitis A	1.4%
571	Diverticulosis	1.4%
572	Hepatic Encephalopathy	1.4%
573	Cushing Syndrome	1.4%
574	Hyperaldosteronism	1.4%
575	Hyperparathyroidism, Secondary	1.4%
576	Hypoaldosteronism	1.4%
577	Thyrotoxicosis	1.4%
578	Hyperparathyroidism, Primary	1.4%
579	Thyroid Hormone Resistance Syndrome	1.4%
580	Adenocarcinoma	1.4%
581	Massive Hepatic Necrosis	1.4%
582	Esophageal Achalasia	1.4%
583	Anal Fissure	1.4%
584	Intestinal Pseudo-Obstruction	1.4%
585	Irritable Bowel Syndrome	1.4%
586	Superior Mesenteric Artery Syndrome	1.4%
587	Emphysematous Cholecystitis	1.4%
588	Neurogenic Bowel	1.4%
589	Sphincter of Oddi Dysfunction	1.4%
590	Anal Ulcer	1.4%
591	Fibromatosis, Aggressive	1.4%
592	Fibromatosis, Abdominal	1.4%
593	Kallmann Syndrome	1.3%
594	Lactose Intolerance	1.3%
595	Diabetic Foot	1.3%
596	Burkitt Lymphoma	1.2%
597	Maxillary Sinus Neoplasms	1.2%
598	Klinefelter Syndrome	1.2%
599	Addison Disease	1.2%
600	Diabetic Angiopathies	1.2%
601	Autoimmune thyroiditis	1.2%
602	Primary Adrenal Insufficiency	1.2%
603	Diabetic Neuropathies	1.2%
604	Myxedema	1.2%
605	Orchitis	1.2%
606	Diabetic Amyotrophy	1.2%
607	Diabetic Autonomic Neuropathy	1.2%
608	Diabetic Cardiomyopathies	1.2%
609	Pruritus Ani	1.2%
610	Ovarian Hyperstimulation Syndrome	1.2%
611	Hyperprolactinemia	1.2%
612	Cryptosporidiosis	1.1%
613	Dupuytren Contracture	1.1%
614	Gigantism	1.1%
615	Diabetic Nephropathy	1.1%
616	Acromegaly	1.1%
617	Anovulation	1.1%
618	Diabetic Ketoacidosis	1.1%
619	Urticaria Pigmentosa	1.1%
620	Oophoritis	1.1%
621	Mycosis Fungoides	1.1%
622	Lymphomatoid Papulosis	1.1%
623	Plasmablastic lymphoma	1.1%
624	Laryngopharyngeal Reflux	1%
625	Cryptorchidism	1%
626	Gonadal Dysgenesis	1%
627	Adrenogenital Syndrome	1%
628	Ovotesticular Disorders of Sex Development	1%
629	Hyperglycemic Hyperosmolar Nonketotic Coma	0.9%
630	Hashimoto Disease	0.9%
631	Hyperandrogenism	0.9%
632	Sezary Syndrome	0.9%
633	Rift Valley Fever	0.8%
634	CREST Syndrome	0.8%
635	Diabetic Retinopathy	0.7%
636	Turner Syndrome	0.7%
637	Waterhouse-Friderichsen Syndrome	0.6%
638	Radicular Cyst	0.6%
639	Renal Osteodystrophy	0.5%
640	Renal rickets	0.5%
641	Adrenoleukodystrophy	0.4%

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