MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cholangitis, Sclerosing

(UMLS:C0008313)

Definition:: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
UMLS ID:: C0008313
MeSH ID:: D015209

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.130.120.200.110

Synonym(s)

Cholangitis, Sclerosing

CHOLANGITIS SCLEROSING

CHOLANGITIS, FIBROSING

CHOLANGITIS, OBLITERATIVE, CHRONIC

Cholangitis sclerosing

Fibrous cholangitis

SCLEROSING CHOLANGITIS

Sclerosing cholangitis

fibrosing cholangitis

10.

sclerosing cholangiitis

11.

sclerosing cholangitis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	24-norursodeoxycholic acid	16472600	CTD
2	3,5-diethoxycarbonyl-1,4-dihydrocollidine	30825315	CTD
3	Bezafibrate	16933007	CTD
4	Danazol	2133530	CTD
5	Floxuridine	View details 1825358 1829068 2521475 2521845 2848277 2933968 2937274 2939001 2949003 2951292 3160062 16633109	CTD
6	Fluorouracil	View details 2060745 2506836 9382546 16633109	CTD
7	Linezolid	17049994	CTD
8	Methimazole	8817448	CTD
9	Minocycline	19098854	CTD
10	N-formylmethionyl-leucyl-tyrosine	8000512	CTD
11	Paclitaxel	19544276	CTD
12	Quinacrine	12666126	CTD
13	Sulfasalazine	17116962	CTD
14	Tretinoin	8695172	CTD
15	Trinitrobenzenesulfonic Acid	12044520	CTD
16	Ursodeoxycholic Acid	7514624 17489059 22942741	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Cholestasis	34.4%
2	Common Bile Duct Diseases	34.4%
3	Cholelithiasis	25.4%
4	Choledocholithiasis	25%
5	Cholestasis, Extrahepatic	22.6%
6	Biliary Dyskinesia	22.6%
7	Bile Duct Neoplasms	21.7%
8	Cholecystolithiasis	19.8%
9	Choledochal Cyst	17.7%
10	Sphincter of Oddi Dysfunction	16.8%
11	Gastrointestinal Diseases	16.4%
12	Liver diseases	16.4%
13	Pancreatic Diseases	16.4%
14	Cholecystitis	14.8%
15	gallbladder neoplasm	13.8%
16	Biliary cirrhosis	13.5%
17	Digestive System Neoplasms	10.8%
18	Acalculous Cholecystitis	9.7%
19	Gastrointestinal Neoplasms	8.5%
20	Liver neoplasms	8.5%
21	Chylous Ascites	8.5%
22	Esophageal Diseases	8.5%
23	Fatty Liver	8.5%
24	Gastroenteritis	8.5%
25	Hepatitis	8.5%
26	Portal Hypertension	8.5%
27	Intestinal Diseases	8.5%
28	Liver Cirrhosis	8.5%
29	Pancreatic Fistula	8.5%
30	Pancreatic Insufficiency	8.5%
31	Pancreatitis	8.5%
32	Pneumoperitoneum	8.5%
33	Stomach Diseases	8.5%
34	Focal Nodular Hyperplasia	8.5%
35	Hepatic Insufficiency	8.5%
36	Steatohepatitis	8.5%
37	Emphysematous Cholecystitis	7.2%
38	Mesenteric vascular insufficiency	6.8%
39	Peritoneal Neoplasms	6.8%
40	Esophageal Atresia	6.7%
41	Intestinal Atresia	6.7%
42	Mesenteric Vascular Occlusion	6.7%
43	Intestinal Fistula	6.7%
44	Enterocutaneous Fistula	6.7%
45	Dysentery	6.6%
46	Enteritis	6.6%
47	Enterocolitis	6.6%
48	Esophageal and Gastric Varices	6.6%
49	Esophagitis	6.6%
50	Gastritis	6.6%
51	Inflammatory Bowel Diseases	6.6%
52	Zollinger-Ellison syndrome	6.4%
53	Liver Diseases, Parasitic	6%
54	Intestinal Neoplasms	5.9%
55	Stomach Neoplasms	5.9%
56	Hepatic Veno-Occlusive Disease	5.7%
57	Pancreatic Cyst	5.7%
58	Peliosis Hepatis	5.7%
59	Hepatopulmonary Syndrome	5.7%
60	Pancreatic Neoplasm	5.7%
61	Anus, Imperforate	5.6%
62	Gastrointestinal Hemorrhage	5.6%
63	Hemoperitoneum	5.6%
64	Hepatomegaly	5.6%
65	Mesenteric Panniculitis	5.6%
66	Panniculitis, Peritoneal	5.6%
67	Peritonitis	5.6%
68	Peritoneal Fibrosis	5.6%
69	Encapsulating Peritoneal Sclerosis	5.6%
70	Anorectal Malformations	5.6%
71	Biliary Fistula	5.6%
72	Gastric Fistula	5.6%
73	Hepatic Vein Thrombosis	5.5%
74	Liver Abscess	5.5%
75	Budd-Chiari Syndrome	5.5%
76	Tuberculosis, Gastrointestinal	5.5%
77	Colitis	5.4%
78	Duodenogastric Reflux	5.4%
79	Peptic Ulcer	5.4%
80	Proctitis	5.4%
81	Esophageal Neoplasms	4.9%
82	Cecal Diseases	4.9%
83	Colonic Diseases	4.9%
84	Esophageal Stenosis	4.9%
85	Hepatitis, Chronic	4.9%
86	Ileal Diseases	4.9%
87	Intestinal Obstruction	4.9%
88	Intestinal Perforation	4.9%
89	Jejunal Diseases	4.9%
90	Pneumatosis Cystoides Intestinalis	4.9%
91	Rectal Diseases	4.9%
92	Gastric Dilatation	4.9%
93	Liver Failure	4.9%
94	Pancreatitis, Chronic	4.9%
95	Gastric outlet obstruction	4.9%
96	Gastrointestinal Stromal Tumors	4.9%
97	Cronkhite-Canada Syndrome	4.9%
98	Non-alcoholic Fatty Liver Disease	4.9%
99	Chronic active hepatitis	4.9%
100	Intestinal Polyposis	4.9%
101	Fatty Liver, Alcoholic	4.9%
102	Hepatitis, Alcoholic	4.9%
103	Liver Cirrhosis, Alcoholic	4.9%
104	Duodenitis	4.8%
105	Ileitis	4.8%
106	Erosive Duodenitis	4.8%
107	Colorectal Neoplasms	4.6%
108	Proctocolitis	4.5%
109	Rectal Fistula	4.5%
110	Anal Fistula	4.5%
111	Chemical and Drug Induced Liver Injury	4.3%
112	Crohn Disease	4.3%
113	Duodenal Obstruction	4.3%
114	Enterocolitis, Neutropenic	4.3%
115	Necrotizing Enterocolitis	4.3%
116	Cecal Neoplasms	4.3%
117	Duodenal Neoplasms	4.3%
118	Hepatorenal Syndrome	4.2%
119	Appendicitis	4.1%
120	Hepatocellular Adenoma	3.9%
121	Duodenal Ulcer	3.7%
122	Peptic Ulcer Perforation	3.7%
123	Gastric ulcer	3.7%
124	Pouchitis	3.6%
125	Esophageal Perforation	3.5%
126	Hepatitis, Animal	3.5%
127	Hepatitis, Viral, Human	3.5%
128	Intestinal Diseases, Parasitic	3.5%
129	Cystic Fibrosis	3.5%
130	Barrett Esophagus	3.4%
131	Deglutition Disorders	3.4%
132	Porphyrias, Hepatic	3.4%
133	Congenital Hyperinsulinism	3.4%
134	Liver Abscess, Amebic	3.3%
135	Liver Neoplasms, Experimental	3.3%
136	Achlorhydria	3.3%
137	Liver Cirrhosis, Experimental	3.3%
138	Pancreatic Pseudocyst	3.3%
139	Gastric Antral Vascular Ectasia	3.3%
140	Peptic Ulcer Hemorrhage	3.3%
141	Gastroparesis	3.3%
142	Pancreatitis, Alcoholic	3.3%
143	Colonic Diseases, Functional	3.2%
144	Enterocolitis, Pseudomembranous	3.2%
145	Esophageal motility disorders	3.2%
146	Fecal Incontinence	3.2%
147	Fecal Impaction	3.2%
148	Intussusception	3.2%
149	Mallory-Weiss Syndrome	3.2%
150	Megacolon	3.2%
151	Pyloric Stenosis	3.2%
152	Liver Failure, Acute	3.2%
153	End Stage Liver Disease	3.2%
154	pseudomembranous colitis	3.2%
155	Ileus	3.2%
156	Dysentery, Bacillary	3.2%
157	Meconium ileus	3.2%
158	Appendiceal Neoplasms	3.2%
159	Colonic Neoplasms	3.2%
160	Rectal Neoplasms	3.2%
161	Anus Neoplasms	2.9%
162	Sigmoid Neoplasms	2.9%
163	Colonic Pseudo-Obstruction	2.9%
164	Colitis, Ischemic	2.9%
165	Adenomatous Polyposis Coli	2.6%
166	Fascioliasis	2.5%
167	Echinococcosis, Hepatic	2.5%
168	Melena	2.5%
169	Chemical and Drug Induced Liver Injury, Chronic	2.5%
170	Reye Syndrome	2.5%
171	Hematemesis	2.4%
172	Carcinoma, Pancreatic Ductal	2.4%
173	Massive Hepatic Necrosis	2.4%
174	Esophageal Achalasia	2.4%
175	Anal Fissure	2.4%
176	Intestinal Pseudo-Obstruction	2.4%
177	Irritable Bowel Syndrome	2.4%
178	Superior Mesenteric Artery Syndrome	2.4%
179	Neurogenic Bowel	2.4%
180	Anal Ulcer	2.4%
181	Hepatitis B, Chronic	2.3%
182	Hepatitis C, Chronic	2.3%
183	Hemorrhoids	2.2%
184	Autoimmune hepatitis	2.2%
185	Afferent Loop Syndrome	2.2%
186	Celiac Disease	2.2%
187	Short Bowel Syndrome	2.2%
188	Sprue, Tropical	2.2%
189	Steatorrhea	2.2%
190	Rectocele	2.2%
191	Sprue	2.2%
192	Diverticulitis	2.2%
193	Dumping Syndrome	2.2%
194	Rectal Prolapse	2.2%
195	Nesidioblastosis	1.9%
196	Variegate Porphyria	1.9%
197	Acute intermittent porphyria	1.9%
198	Porphyria Cutanea Tarda	1.9%
199	insulinoma	1.8%
200	Gastrinoma	1.8%
201	Glucagonoma	1.8%
202	Hepatitis, Viral, Animal	1.8%
203	Giardiasis	1.7%
204	Hepatitis E	1.7%
205	Hepatitis B	1.7%
206	Hepatitis C	1.7%
207	Diverticulum	1.7%
208	Hepatitis A	1.7%
209	Diverticulosis	1.7%
210	Hepatic Encephalopathy	1.6%
211	Pruritus Ani	1.6%
212	Vipoma	1.6%
213	Zellweger Syndrome	1.5%
214	Laryngopharyngeal Reflux	1.4%
215	Hepatolenticular Degeneration	1.4%
216	Peutz-Jeghers Syndrome	1.3%
217	Lactose Intolerance	1.3%
218	Cryptosporidiosis	1%
219	Rift Valley Fever	0.7%
220	CREST Syndrome	0.7%

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