MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hepatorenal Syndrome

(UMLS:C0019212)

Definition:: Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
UMLS ID:: C0019212
MeSH ID:: D006530

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.465

Classification 2:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.291

Classification 3:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.291

Synonym(s)

Hepatorenal Syndrome

HEPATORENAL SYNDROME

HEYD SYNDROME

HRF - Hepatorenal failure

Hepatorenal failure

Hepatorenal syndrome

Heyd's syndrome

RENAL FAILURE SECONDARY TO LIVER DISEASE

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 11		US FAERS
2	Acetaminophen	FAERS: 9		US FAERS
3	Simvastatin	FAERS: 9		US FAERS
4	Metformin	FAERS: 8		US FAERS
5	Sorafenib	FAERS: 7		US FAERS
6	Tacrolimus	FAERS: 7		US FAERS
7	Sitagliptin Phosphate	FAERS: 5		US FAERS
8	Cyclosporine	FAERS: 4		US FAERS
9	Dexamethasone	FAERS: 4		US FAERS
10	Everolimus	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
11	Rifaximin	FAERS: 4		US FAERS
12	Rosiglitazone	FAERS: 4		US FAERS
13	Tenofovir	FAERS: 4		US FAERS
14	gemcitabine	FAERS: 4		US FAERS
15	Amoxicillin-Potassium Clavulanate Combination	FAERS: 3		US FAERS
16	Dabigatran	FAERS: 3		US FAERS
17	Hydroxyzine	FAERS: 3		US FAERS
18	Prednisolone	FAERS: 3		US FAERS
19	Sevoflurane	FAERS: 3		US FAERS
20	macitentan	FAERS: 3		US FAERS
21	obeticholic acid	FAERS: 3		US FAERS
22	treprostinil	FAERS: 3		US FAERS
23	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2		US FAERS
24	Bosentan	FAERS: 2		US FAERS
25	Capecitabine	FAERS: 2		US FAERS
26	Deferasirox	FAERS: 2		US FAERS
27	Diclofenac	FAERS: 2		SIDER US FAERS
28	Dronedarone	FAERS: 2		US FAERS
29	Erlotinib Hydrochloride	FAERS: 2		US FAERS
30	Lamivudine	FAERS: 2		US FAERS
31	Linezolid	FAERS: 2		US FAERS
32	Moxifloxacin	FAERS: 2		US FAERS
33	Propofol	FAERS: 2		US FAERS
34	Rivaroxaban	FAERS: 2		US FAERS
35	Sildenafil Citrate	FAERS: 2		US FAERS
36	Telbivudine	FAERS: 2		US FAERS
37	Tolvaptan	FAERS: 2		US FAERS
38	ambrisentan	FAERS: 2		US FAERS
39	gemcitabine	FAERS: 2		US FAERS
40	ledipasvir, sofosbuvir drug combination	FAERS: 2		US FAERS
41	liposomal doxorubicin	FAERS: 2		US FAERS
42	pasireotide	FAERS: 2		US FAERS
43	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
44	Afatinib	FAERS: 1		US FAERS
45	Albuterol	FAERS: 1		US FAERS
46	Amiodarone	FAERS: 1		US FAERS
47	Atorvastatin	FAERS: 1		US FAERS
48	Baclofen	FAERS: 1		US FAERS
49	Carbamazepine	FAERS: 1		US FAERS
50	Cephalexin	FAERS: 1		US FAERS
51	Citalopram	FAERS: 1		US FAERS
52	Crizotinib	FAERS: 1		US FAERS
53	Daclatasvir dihydrochloride	FAERS: 1		US FAERS
54	Dapsone	FAERS: 1		US FAERS
55	Dasatinib	FAERS: 1		US FAERS
56	Deferoxamine	FAERS: 1		US FAERS
57	Digoxin	FAERS: 1		US FAERS
58	Epoprostenol	FAERS: 1		US FAERS
59	Ezetimibe, Simvastatin Drug Combination	FAERS: 1		US FAERS
60	GS-7340	FAERS: 1		US FAERS
61	Halothane	FAERS: 1		US FAERS
62	INCB018424	FAERS: 1		US FAERS
63	Insulin Glargine	FAERS: 1		US FAERS
64	Isoflurane	FAERS: 1		US FAERS
65	Ketoconazole	FAERS: 1		US FAERS
66	LCZ 696	FAERS: 1		US FAERS
67	Labetalol	FAERS: 1		US FAERS
68	Lansoprazole	FAERS: 1		US FAERS
69	Lapatinib	FAERS: 1		US FAERS
70	Leflunomide	FAERS: 1		US FAERS
71	Mycophenolic Acid	FAERS: 1		US FAERS
72	Nafcillin	FAERS: 1		US FAERS
73	Ofloxacin	FAERS: 1		US FAERS
74	Oseltamivir	FAERS: 1		US FAERS
75	Pantoprazole	FAERS: 1		US FAERS
76	Phenytoin	FAERS: 1		US FAERS
77	Propranolol	FAERS: 1		US FAERS
78	Risperidone	FAERS: 1		US FAERS
79	Sofosbuvir	FAERS: 1		US FAERS
80	Sunitinib	FAERS: 1		US FAERS
81	Tadalafil	FAERS: 1		US FAERS
82	Tamoxifen	FAERS: 1		US FAERS
83	Thiotepa	FAERS: 1		US FAERS
84	Ticlopidine	FAERS: 1		US FAERS
85	Tigecycline	FAERS: 1		US FAERS
86	Vancomycin	FAERS: 1		US FAERS
87	apixaban	FAERS: 1		US FAERS
88	dolutegravir	FAERS: 1		US FAERS
89	entecavir	FAERS: 1		SIDER US FAERS
90	ferrous sulfate	FAERS: 1		US FAERS
91	lenvatinib	FAERS: 1		US FAERS
92	peramivir	FAERS: 1		US FAERS
93	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
94	telithromycin	FAERS: 1		US FAERS
95	venetoclax	FAERS: 1		US FAERS
96	Amitriptyline		11092117	CTD
97	Azithromycin	Canada Vigilance: 2		Canada Vigilance
98	Citalopram		15930079	CTD
99	Cyproterone Acetate	Canada Vigilance: 1		Canada Vigilance
100	Cytarabine		2319616	CTD
101	Digitoxin		11051385	CTD
102	Erlotinib Hydrochloride			SIDER
103	Felbamate			SIDER
104	Fentanyl			SIDER
105	Fluvoxamine		15930079	CTD
106	Ibuprofen			SIDER
107	Levofloxacin	Canada Vigilance: 1		Canada Vigilance
108	Minocycline		8470208	CTD
109	Propranolol		11051385	CTD
110	Terlipressin		11051385	CTD
111	adefovir dipivoxil		14647053	CTD
112	tezosentan		16219361	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anuria	39.8%
2	Nephrolithiasis	39.8%
3	Hydronephrosis	38.7%
4	Hyperoxaluria	38.7%
5	Kidney Cortex Necrosis	38.7%
6	Kidney Papillary Necrosis	38.7%
7	Nephritis	38.7%
8	Nephrosclerosis	38.7%
9	Nephrosis	38.7%
10	Perinephritis	38.7%
11	Kidney Failure	38.7%
12	Uremia	38.7%
13	Oxalosis	38.7%
14	Renal Insufficiency	38.7%
15	Pyelonephritis	33.6%
16	Diabetes Insipidus	32.6%
17	Diabetic Nephropathy	32.2%
18	Renal hypertension	32.2%
19	Renal Artery Obstruction	32.2%
20	Renal Artery Stenosis	32.2%
21	Nephrocalcinosis	32%
22	Tuberculosis, Renal	30.4%
23	Glomerulonephritis	28.7%
24	Nephritis, Interstitial	28.7%
25	Lipoid nephrosis	28.7%
26	Nephrotic Syndrome	28.7%
27	Pyelitis	28.7%
28	Pyonephrosis	28.7%
29	Nephrogenic Diabetes Insipidus	28.7%
30	Congenital Nephrogenic Diabetes Insipidus	28.7%
31	Acute kidney injury	28.7%
32	Kidney Neoplasm	28.1%
33	Kidney Calculi	26.8%
34	Urinary Bladder Diseases	26.5%
35	Ureteral Diseases	26.5%
36	Urethral Diseases	26.5%
37	Urination Disorders	26.5%
38	Urolithiasis	26.5%
39	Pyelocystitis	26%
40	Ureterolithiasis	24.6%
41	Multicystic Dysplastic Kidney	24.4%
42	Azotemia	24.2%
43	AIDS-Associated Nephropathy	23.9%
44	Hypertension, Renovascular	23.8%
45	Balkan Nephropathy	23.8%
46	Focal glomerulosclerosis	23.8%
47	Kidney Failure, Chronic	23.8%
48	Biliary cirrhosis	22.4%
49	Urinary tract infection	22.3%
50	Bladder neck obstruction	21.4%
51	Zellweger Syndrome	20.8%
52	Glomerulonephritis, Membranoproliferative	20.6%
53	Polycystic Kidney Diseases	20.6%
54	Glycosuria, Renal	20.5%
55	Fatty Liver	20.5%
56	Hepatitis	20.5%
57	Portal Hypertension	20.5%
58	Liver Cirrhosis	20.5%
59	Focal Nodular Hyperplasia	20.5%
60	Hepatic Insufficiency	20.5%
61	Steatohepatitis	20.5%
62	Renal Aminoacidurias	20.4%
63	Fanconi Syndrome	20.4%
64	Pseudohypoaldosteronism	20.4%
65	Liddle Syndrome	20.4%
66	Hemolytic-Uremic Syndrome	20.3%
67	Fatty Liver, Alcoholic	19.9%
68	Hepatitis, Alcoholic	19.9%
69	Liver Cirrhosis, Alcoholic	19.9%
70	Ureteral Calculi	19%
71	Renal Osteodystrophy	19%
72	Renal rickets	19%
73	Mesoblastic Nephroma	18.5%
74	Renal Cell Carcinoma	18.4%
75	Papillary Renal Cell Carcinoma	18.4%
76	Liver neoplasms	18.3%
77	Renal tubular acidosis	17.8%
78	Cystitis	17.3%
79	Ureteral obstruction	17.3%
80	Ureterocele	17.3%
81	Urethral Obstruction	17.3%
82	Urethritis	17.3%
83	Vesico-Ureteral Reflux	17.3%
84	Urinary Retention	17.3%
85	Anti-Glomerular Basement Membrane Disease	17.2%
86	Bladder Exstrophy	17.2%
87	Epispadias	17.2%
88	Lupus Nephritis	17.1%
89	Liver Diseases, Parasitic	17%
90	Polycystic Kidney, Autosomal Dominant	16.9%
91	Cystinuria	16.8%
92	Atypical Hemolytic Uremic Syndrome	16.8%
93	Hepatic Veno-Occlusive Disease	16.6%
94	Peliosis Hepatis	16.6%
95	Hepatopulmonary Syndrome	16.6%
96	Hepatomegaly	16.3%
97	Hepatic Vein Thrombosis	16.2%
98	Liver Abscess	16.2%
99	Budd-Chiari Syndrome	16.2%
100	Esophageal and Gastric Varices	16.1%
101	Nephroblastoma	15.3%
102	Hepatitis, Chronic	15.1%
103	Liver Failure	15.1%
104	Non-alcoholic Fatty Liver Disease	15.1%
105	Chronic active hepatitis	15.1%
106	Liver Abscess, Amebic	15.1%
107	Urinary Bladder Fistula	14.9%
108	Bladder Neoplasm	14.9%
109	Ureteral Neoplasms	14.9%
110	Urethral Neoplasms	14.9%
111	Urogenital Abnormalities	14.8%
112	Bacteriuria	14.4%
113	Glycosuria	14.4%
114	Hematuria	14.4%
115	Oliguria	14.4%
116	Polyuria	14.4%
117	Proteinuria	14.4%
118	Pyuria	14.4%
119	Urinary Calculi	14.4%
120	Cystocele	14.4%
121	Urinary Incontinence	14.4%
122	Hyperphosphaturia	14.2%
123	Chemical and Drug Induced Liver Injury	13.9%
124	Hepatitis B, Chronic	13.4%
125	Hepatitis C, Chronic	13.4%
126	Urethral Stenosis	12.9%
127	Urethral stricture	12.9%
128	Hepatitis, Animal	12.6%
129	Hepatitis, Viral, Human	12.6%
130	Enuresis	12.5%
131	Liver Failure, Acute	12.5%
132	End Stage Liver Disease	12.5%
133	Liver Cirrhosis, Experimental	12.1%
134	Porphyrias, Hepatic	11.6%
135	Hepatocellular Adenoma	11.4%
136	Massive Hepatic Necrosis	11.2%
137	Zollinger-Ellison syndrome	11.1%
138	Denys-Drash Syndrome	10.8%
139	Albuminuria	10.7%
140	Hemoglobinuria	10.7%
141	Urge Incontinence	10.7%
142	Biliary Tract Diseases	10.6%
143	Gastrointestinal Diseases	10.6%
144	Pancreatic Diseases	10.6%
145	Infertility	10.2%
146	Fascioliasis	10.2%
147	Autoimmune hepatitis	10.1%
148	Echinococcosis, Hepatic	10.1%
149	Chemical and Drug Induced Liver Injury, Chronic	10.1%
150	Liver Neoplasms, Experimental	10%
151	Reye Syndrome	10%
152	Proctocolitis	9.6%
153	Hypospadias	9.2%
154	Diurnal Enuresis	9.2%
155	Gastrointestinal Neoplasms	9.1%
156	Pancreatic Fistula	9.1%
157	Colorectal Neoplasms	9.1%
158	Genital Diseases, Male	8.8%
159	Hepatitis, Viral, Animal	8.7%
160	Bile Duct Neoplasms	8.6%
161	gallbladder neoplasm	8.6%
162	Intestinal Neoplasms	8.6%
163	Stomach Neoplasms	8.6%
164	Hepatitis E	8.5%
165	Digestive System Neoplasms	8.5%
166	Variegate Porphyria	8.5%
167	Acute intermittent porphyria	8.5%
168	Porphyria Cutanea Tarda	8.5%
169	Urologic Neoplasms	8.5%
170	Horseshoe Kidney	8.5%
171	Hepatitis B	8.4%
172	Hepatitis C	8.4%
173	Hepatitis A	8.4%
174	Hepatic Encephalopathy	8.3%
175	Duodenitis	8.2%
176	Ileitis	8.2%
177	Erosive Duodenitis	8.2%
178	Cecal Neoplasms	8.2%
179	Duodenal Neoplasms	8.2%
180	Dysentery	8.1%
181	Enteritis	8.1%
182	Enterocolitis	8.1%
183	Esophagitis	8.1%
184	Gastritis	8.1%
185	Inflammatory Bowel Diseases	8.1%
186	Cholecystolithiasis	8.1%
187	Mesenteric vascular insufficiency	8%
188	Pregnancy Complications	8%
189	Vesicovaginal Fistula	7.9%
190	Esophageal Atresia	7.9%
191	Intestinal Atresia	7.9%
192	Mesenteric Vascular Occlusion	7.9%
193	Intestinal Fistula	7.9%
194	Enterocutaneous Fistula	7.9%
195	Peritoneal Neoplasms	7.8%
196	Familial Hypophosphatemic Rickets	7.8%
197	Anus Neoplasms	7.7%
198	Sigmoid Neoplasms	7.7%
199	Endometriosis	7.6%
200	Uterine Diseases	7.6%
201	Vaginal Diseases	7.6%
202	Vulvar Diseases	7.6%
203	Endometrioma	7.6%
204	Sexually Transmitted Diseases	7.5%
205	Rectal Fistula	7.5%
206	Anal Fistula	7.5%
207	Esophageal Neoplasms	7.5%
208	Pouchitis	7.4%
209	Colitis	7.3%
210	Duodenogastric Reflux	7.3%
211	Peptic Ulcer	7.3%
212	Proctitis	7.3%
213	Choledocholithiasis	7.3%
214	Hermaphroditism	7.3%
215	Disorders of Sex Development	7.3%
216	Appendiceal Neoplasms	7.3%
217	Colonic Neoplasms	7.3%
218	Rectal Neoplasms	7.3%
219	Genital Herpes	7.2%
220	Endometritis	6.9%
221	Pancreatic Neoplasm	6.9%
222	Genital Neoplasms, Male	6.9%
223	Bile Duct Diseases	6.8%
224	Cholelithiasis	6.8%
225	Chylous Ascites	6.8%
226	Esophageal Diseases	6.8%
227	Gastroenteritis	6.8%
228	Intestinal Diseases	6.8%
229	Pancreatic Insufficiency	6.8%
230	Pancreatitis	6.8%
231	Pneumoperitoneum	6.8%
232	Stomach Diseases	6.8%
233	Choledochal Cyst	6.8%
234	Gastrointestinal Stromal Tumors	6.7%
235	Crohn Disease	6.6%
236	Duodenal Obstruction	6.6%
237	Enterocolitis, Neutropenic	6.6%
238	Necrotizing Enterocolitis	6.6%
239	Uterine Neoplasms	6.6%
240	Vaginal Neoplasms	6.6%
241	Vulvar Neoplasms	6.6%
242	Uterine Cancer	6.6%
243	Duodenal Ulcer	6.3%
244	Peptic Ulcer Perforation	6.3%
245	Gastric ulcer	6.3%
246	Adenomatous Polyposis Coli	6.3%
247	Appendicitis	6.1%
248	Genital Neoplasms, Female	6%
249	Uterine Inversion	6%
250	Salpingitis	5.9%
251	Vulvovaginitis	5.9%
252	Fallopian Tube Neoplasms	5.8%
253	Colonic Pseudo-Obstruction	5.7%
254	Penile Neoplasms	5.7%
255	Prostatic Neoplasms	5.7%
256	Hepatolenticular Degeneration	5.7%
257	Dyspareunia	5.6%
258	Pancreatic Cyst	5.5%
259	Enterocolitis, Pseudomembranous	5.5%
260	pseudomembranous colitis	5.5%
261	Dysentery, Bacillary	5.5%
262	Anus, Imperforate	5.4%
263	Gastrointestinal Hemorrhage	5.4%
264	Hemoperitoneum	5.4%
265	Mesenteric Panniculitis	5.4%
266	Panniculitis, Peritoneal	5.4%
267	Peritonitis	5.4%
268	Peritoneal Fibrosis	5.4%
269	Encapsulating Peritoneal Sclerosis	5.4%
270	Anorectal Malformations	5.4%
271	Biliary Fistula	5.4%
272	Gastric Fistula	5.4%
273	Tuberculosis, Gastrointestinal	5.4%
274	Colitis, Ischemic	5.3%
275	Epididymitis	5.1%
276	Penile Diseases	5.1%
277	Prostatic Diseases	5.1%
278	Spermatic Cord Torsion	5.1%
279	Hemospermia	5.1%
280	Testicular Hydrocele	5.1%
281	Rift Valley Fever	5.1%
282	Uterine Rupture	5.1%
283	Cecal Diseases	5%
284	Cholangitis	5%
285	Cholecystitis	5%
286	Cholestasis	5%
287	Colonic Diseases	5%
288	Common Bile Duct Diseases	5%
289	Esophageal Stenosis	5%
290	Ileal Diseases	5%
291	Intestinal Obstruction	5%
292	Intestinal Perforation	5%
293	Jejunal Diseases	5%
294	Pneumatosis Cystoides Intestinalis	5%
295	Rectal Diseases	5%
296	Gastric Dilatation	5%
297	Pancreatitis, Chronic	5%
298	Gastric outlet obstruction	5%
299	Cronkhite-Canada Syndrome	5%
300	Intestinal Polyposis	5%
301	Endometrial Hyperplasia	5%
302	Pyometra	5%
303	Vaginitis	5%
304	Vulvitis	5%
305	Vaginal Discharge	5%
306	Vulvodynia	5%
307	Oophoritis	4.9%
308	Endometrial Neoplasms	4.9%
309	Cryptorchidism	4.8%
310	Gonadal Dysgenesis	4.7%
311	Adrenogenital Syndrome	4.7%
312	Ovotesticular Disorders of Sex Development	4.7%
313	Hyperandrogenism	4.4%
314	ovarian neoplasm	4.4%
315	Carcinoma, Endometrioid	4.3%
316	Uterine Cervical Incompetence	4.3%
317	Polyhydramnios	4.3%
318	Obstetric Labor Complications	4.3%
319	Ectopic Pregnancy	4.3%
320	Pregnancy, Prolonged	4.3%
321	Puerperal Disorders	4.3%
322	Oligohydramnios	4.3%
323	Prenatal Injuries	4.3%
324	Prostatic Neoplasms, Castration-Resistant	4.2%
325	Esophageal Perforation	4.2%
326	Intestinal Diseases, Parasitic	4.2%
327	Cholestasis, Extrahepatic	4.2%
328	Biliary Dyskinesia	4.2%
329	Cholangitis, Sclerosing	4.2%
330	Colonic Diseases, Functional	4.2%
331	Esophageal motility disorders	4.2%
332	Fecal Incontinence	4.2%
333	Fecal Impaction	4.2%
334	Intussusception	4.2%
335	Mallory-Weiss Syndrome	4.2%
336	Megacolon	4.2%
337	Pyloric Stenosis	4.2%
338	Acalculous Cholecystitis	4.2%
339	Ileus	4.2%
340	Meconium ileus	4.2%
341	Testicular Diseases	4.1%
342	Varicocele	4.1%
343	Candidiasis, Vulvovaginal	4.1%
344	Barrett Esophagus	4.1%
345	Deglutition Disorders	4.1%
346	Spermatocele	4.1%
347	Ovarian Diseases	4.1%
348	Abruptio Placentae	4%
349	Achlorhydria	4%
350	Pancreatic Pseudocyst	4%
351	Placenta Accreta	4%
352	Gastric Antral Vascular Ectasia	4%
353	Adnexitis	4%
354	Peptic Ulcer Hemorrhage	4%
355	Pruritus Vulvae	4%
356	Uterine hemorrhage	4%
357	Vaginal Fistula	4%
358	Gastroparesis	4%
359	Pelvic Inflammatory Disease	4%
360	Pancreatitis, Alcoholic	4%
361	Cystic Fibrosis	4%
362	Uterine Prolapse	4%
363	Vaginal Prolapse	4%
364	Carcinoma, Pancreatic Ductal	3.9%
365	Congenital Hyperinsulinism	3.9%
366	Chorioamnionitis	3.8%
367	Uterine Cervicitis	3.7%
368	Esophageal Achalasia	3.7%
369	Anal Fissure	3.7%
370	Intestinal Pseudo-Obstruction	3.7%
371	Irritable Bowel Syndrome	3.7%
372	Leukorrhea	3.7%
373	Parametritis	3.7%
374	Superior Mesenteric Artery Syndrome	3.7%
375	Emphysematous Cholecystitis	3.7%
376	Neurogenic Bowel	3.7%
377	Sphincter of Oddi Dysfunction	3.7%
378	Anal Ulcer	3.7%
379	insulinoma	3.6%
380	Gastrinoma	3.6%
381	Glucagonoma	3.6%
382	Fetal Diseases	3.5%
383	Pregnancy Complications, Cardiovascular	3.5%
384	Pregnancy Complications, Neoplastic	3.5%
385	Pregnancy Complications, Hematologic	3.4%
386	Pregnancy Complications, Infectious	3.4%
387	Fetal Death	3.4%
388	Perinatal death	3.4%
389	Hemorrhoids	3.4%
390	Morning Sickness	3.4%
391	Melena	3.4%
392	Balanitis	3.4%
393	Benign prostatic hypertrophy	3.4%
394	Phimosis	3.4%
395	Priapism	3.4%
396	prostatitis	3.4%
397	Prostatic Adenoma	3.4%
398	Benign Prostatic Hyperplasia	3.4%
399	Prostatic Hypertrophy	3.4%
400	Prostatic Hyperplasia	3.4%
401	Puerperal Infection	3.4%
402	Afferent Loop Syndrome	3.3%
403	Celiac Disease	3.3%
404	Postpartum Hemorrhage	3.3%
405	Short Bowel Syndrome	3.3%
406	Sprue, Tropical	3.3%
407	Steatorrhea	3.3%
408	Rectocele	3.3%
409	Sprue	3.3%
410	Hematemesis	3.3%
411	Diverticulitis	3.3%
412	Dumping Syndrome	3.3%
413	Rectal Prolapse	3.3%
414	Vipoma	3.2%
415	Endometrial Stromal Sarcoma	3.2%
416	Chlamydia Infections	3.1%
417	Gonorrhea	3.1%
418	Turner Syndrome	3%
419	Bacterial Vaginosis	3%
420	granulosa cell tumor	3%
421	Carcinoma, Ovarian Epithelial	3%
422	Pruritus Ani	3%
423	Trichomonas Vaginitis	3%
424	Uterine Perforation	3%
425	Ovarian Hyperstimulation Syndrome	3%
426	Testicular Neoplasms	3%
427	Metrorrhagia	3%
428	Laryngopharyngeal Reflux	2.9%
429	Giardiasis	2.8%
430	Gestational Diabetes	2.8%
431	Nesidioblastosis	2.8%
432	Diverticulum	2.8%
433	Diverticulosis	2.8%
434	Kallmann Syndrome	2.8%
435	Syphilis	2.7%
436	Premature Ejaculation	2.7%
437	Erectile dysfunction	2.7%
438	Orchitis	2.7%
439	Lymphogranuloma Venereum	2.5%
440	Abortion, Habitual	2.5%
441	Corpus Luteum Cyst	2.5%
442	Dystocia	2.5%
443	Eclampsia	2.5%
444	Fetal Membranes, Premature Rupture	2.5%
445	Ovarian Cysts	2.5%
446	Placental Insufficiency	2.5%
447	Pre-Eclampsia	2.5%
448	Prenatal Exposure Delayed Effects	2.5%
449	HELLP Syndrome	2.5%
450	Placenta, Retained	2.5%
451	Azoospermia	2.5%
452	Oligospermia	2.5%
453	Impotence, Vasculogenic	2.5%
454	Asthenozoospermia	2.5%
455	Teratozoospermia	2.5%
456	Aspermia	2.5%
457	Anovulation	2.5%
458	Menorrhagia	2.5%
459	Premature Menopause	2.5%
460	Klinefelter Syndrome	2.4%
461	Peutz-Jeghers Syndrome	2.4%
462	Lactose Intolerance	2.4%
463	Abortion, Veterinary	2.1%
464	Pregnancy Complications, Parasitic	2.1%
465	Polycystic Ovary Syndrome	2.1%
466	Lactation Disorder	2%
467	Mastitis	2%
468	Depression, Postpartum	2%
469	Embryo Loss	2%
470	Fetal Resorption	2%
471	Hyperemesis Gravidarum	2%
472	Cryptosporidiosis	1.9%
473	Fetal Growth Retardation	1.7%
474	Trophoblastic Neoplasms	1.7%
475	Embolism, Amniotic Fluid	1.7%
476	Fetal Hypoxia	1.7%
477	Fetal Alcohol Spectrum Disorders	1.7%
478	Premature Birth	1.7%
479	Breech Presentation	1.7%
480	Stillbirth	1.7%
481	CREST Syndrome	1.6%
482	Leydig Cell Tumor	1.6%
483	Galactorrhea	1.3%
484	Meconium Aspiration Syndrome	1.3%
485	Choriocarcinoma	0.9%
486	Hydatidiform Mole	0.8%
487	Hydrops Fetalis	0.7%

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