MetaADEDB 2.0 @ LMMD
Anal Fissure
(UMLS:C0016167)
Definition:
A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)
UMLS ID:
C0016167
MeSH ID:
D005401
Classification:
Name:
Digestive System Diseases
MeSH Tree Number(s):
C06.405.469.860.101.430
Synonym(s)
1.
Anal Fissure
2.
ANAL FISSURE
3.
Anal fissure
4.
Anal fissure, unspecified
5.
FISSURE IN ANO
6.
Fissure in ano
7.
Fissure-in-ano
8.
Fissure;anal
9.
Nontraumatic tear of anus
10.
Ulcer of anus
11.
anal fissure
12.
anal fissures
13.
anus; fissure
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1IsotretinoinFAERS: 579
Canada Vigilance: 1		Canada Vigilance
US FAERS
2OctreotideFAERS: 17
Canada Vigilance: 1		Canada Vigilance
US FAERS
3rofecoxibFAERS: 15OFFSIDES
US FAERS
4Olmesartan MedoxomilFAERS: 14US FAERS
5SunitinibFAERS: 12OFFSIDES
US FAERS
6Imatinib MesylateFAERS: 9US FAERS
7TopiramateFAERS: 9US FAERS
8AzacitidineFAERS: 5OFFSIDES
US FAERS
9Benicar hctFAERS: 5US FAERS
10FinasterideFAERS: 5US FAERS
11EverolimusFAERS: 4US FAERS
12NorgestrelFAERS: 4US FAERS
13NuvaRingFAERS: 4OFFSIDES
US FAERS
14SorafenibFAERS: 4US FAERS
15Zoledronic AcidFAERS: 4US FAERS
16candesartan cilexetilFAERS: 4US FAERS
174-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 3US FAERS
18CiprofloxacinFAERS: 3
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
19DabigatranFAERS: 3US FAERS
20LapatinibFAERS: 3OFFSIDES
US FAERS
21OrlistatFAERS: 3OFFSIDES
US FAERS
22TeriparatideFAERS: 3US FAERS
23ThyroxineFAERS: 3US FAERS
24Valproic AcidFAERS: 3OFFSIDES
US FAERS
25VareniclineFAERS: 3US FAERS
26pazopanibFAERS: 3US FAERS
27regorafenibFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
28sibutramineFAERS: 3US FAERS
29AfatinibFAERS: 2US FAERS
30AlendronateFAERS: 2US FAERS
31Aspirin-oxycodone hydrochloride-oxycodone terephthalate combinationFAERS: 2US FAERS
32Atomoxetine HydrochlorideFAERS: 2US FAERS
33AtorvastatinFAERS: 2US FAERS
34BupropionFAERS: 2US FAERS
35CapecitabineFAERS: 2US FAERS
36CelecoxibFAERS: 2OFFSIDES
US FAERS
37CiprofloxacinFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
38ClozapineFAERS: 2US FAERS
39DasatinibFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
40DiclofenacFAERS: 2US FAERS
41Dimethyl FumarateFAERS: 2US FAERS
42Duloxetine HydrochlorideFAERS: 2US FAERS
43Erlotinib HydrochlorideFAERS: 2US FAERS
44IbuprofenFAERS: 2OFFSIDES
US FAERS
45Imatinib MesylateFAERS: 2US FAERS
46LenalidomideFAERS: 2US FAERS
47ParoxetineFAERS: 2OFFSIDES
US FAERS
48PhenytoinFAERS: 2US FAERS
49RisperidoneFAERS: 2US FAERS
50RivaroxabanFAERS: 2US FAERS
51Rosuvastatin CalciumFAERS: 2US FAERS
52apixabanFAERS: 2US FAERS
53ponatinibFAERS: 2US FAERS
54telaprevirFAERS: 2US FAERS
554-hydroxybutyric acidFAERS: 1US FAERS
56AcetaminophenFAERS: 1US FAERS
57AlprazolamFAERS: 1US FAERS
58Amoxicillin-Potassium Clavulanate CombinationFAERS: 1US FAERS
59AripiprazoleFAERS: 1US FAERS
60ArthrotecFAERS: 1US FAERS
61AxitinibFAERS: 1US FAERS
62BortezomibFAERS: 1OFFSIDES
SIDER
US FAERS
63BuspironeFAERS: 1US FAERS
64CarbamazepineFAERS: 1US FAERS
65ClindamycinFAERS: 1US FAERS
66DabigatranFAERS: 1US FAERS
67DiltiazemFAERS: 1US FAERS
68EsomeprazoleFAERS: 1US FAERS
69Ethinyl Estradiol-Norgestrel CombinationFAERS: 1US FAERS
70EtodolacFAERS: 1US FAERS
71EtoposideFAERS: 1US FAERS
72Ferric Oxide, SaccharatedFAERS: 1US FAERS
73FluorouracilFAERS: 1OFFSIDES
US FAERS
74Glatiramer AcetateFAERS: 1US FAERS
75HydrocortisoneFAERS: 1US FAERS
76Insulin GlargineFAERS: 1US FAERS
77Iron citrateFAERS: 1US FAERS
78LetrozoleFAERS: 1US FAERS
79LiraglutideFAERS: 1US FAERS
80LoperamideFAERS: 1US FAERS
81Loratadine and pseudoephedrine sulfateFAERS: 1US FAERS
82MesalamineFAERS: 1US FAERS
83MetronidazoleFAERS: 1US FAERS
84MorphineFAERS: 1US FAERS
85MoxifloxacinFAERS: 1US FAERS
86Nexium 24hrFAERS: 1US FAERS
87OndansetronFAERS: 1US FAERS
88PCI 32765FAERS: 1US FAERS
89Paliperidone PalmitateFAERS: 1US FAERS
90PantoprazoleFAERS: 1US FAERS
91PhentermineFAERS: 1OFFSIDES
US FAERS
92PiroxicamFAERS: 1OFFSIDES
US FAERS
93PrednisoloneFAERS: 1US FAERS
94Quetiapine FumarateFAERS: 1US FAERS
95Ruxolitinib phosphateFAERS: 1US FAERS
96SertralineFAERS: 1OFFSIDES
US FAERS
97SevelamerFAERS: 1OFFSIDES
US FAERS
98SimeprevirFAERS: 1US FAERS
99SimvastatinFAERS: 1US FAERS
100Sitagliptin PhosphateFAERS: 1US FAERS
101SunitinibFAERS: 1OFFSIDES
US FAERS
102TicagrelorFAERS: 1US FAERS
103VoriconazoleFAERS: 1US FAERS
104WarfarinFAERS: 1US FAERS
105WarfarinFAERS: 1US FAERS
106ZolpidemFAERS: 1US FAERS
107aclidinium bromideFAERS: 1US FAERS
108amcinonideFAERS: 1US FAERS
109cabozantinibFAERS: 1SIDER
US FAERS
110cefuroxime axetilFAERS: 1US FAERS
111clindamycin phosphateFAERS: 1OFFSIDES
US FAERS
112etonogestrelFAERS: 1US FAERS
113exemestaneFAERS: 1US FAERS
114fesoterodineFAERS: 1US FAERS
115linaclotideFAERS: 1US FAERS
116macitentanFAERS: 1US FAERS
117oxybutyninFAERS: 1US FAERS
118palbociclibFAERS: 1US FAERS
119pimecrolimusFAERS: 1OFFSIDES
US FAERS
120posaconazoleFAERS: 1US FAERS
121reviparinFAERS: 1US FAERS
122sapropterinFAERS: 1US FAERS
123zolmitriptanFAERS: 1US FAERS
1241-methylcyclopropeneOFFSIDES
125AdapaleneOFFSIDES
126AlbuterolOFFSIDES
127AllopurinolOFFSIDES
128Aminocaproic AcidOFFSIDES
129AmpicillinOFFSIDES
130AprepitantOFFSIDES
131AzathioprineOFFSIDES
132Benzoyl PeroxideOFFSIDES
133BenztropineOFFSIDES
134BumetanideOFFSIDES
135Butylscopolammonium BromideOFFSIDES
136CaffeineOFFSIDES
137Calcium CitrateOFFSIDES
138CarboplatinOFFSIDES
139CefoxitinOFFSIDES
140CeftazidimeOFFSIDES
141ChlorothiazideOFFSIDES
142CiclopiroxOFFSIDES
143CimetidineOFFSIDES
144CitalopramSIDER
145ClindamycinOFFSIDES
146ClotrimazoleOFFSIDES
147D-TelaprevirSIDER
148DantroleneOFFSIDES
149DesonideOFFSIDES
150DicyclomineOFFSIDES
151DidanosineOFFSIDES
152Dioctyl Sulfosuccinic AcidOFFSIDES
153DiphenhydramineOFFSIDES
154DipyroneOFFSIDES
155Docusate sodiumOFFSIDES
156DomperidoneOFFSIDES
157EconazoleOFFSIDES
158ErythromycinOFFSIDES
159Fluocinolone AcetonideOFFSIDES
160FluocinonideOFFSIDES
161FluorometholoneOFFSIDES
162FluoxetineOFFSIDES
163FluvastatinOFFSIDES
164GemfibrozilOFFSIDES
165GliclazideSIDER
166GlucovanceOFFSIDES
167GlycerolOFFSIDES
168HydralazineOFFSIDES
169HydromorphoneSIDER
170IfosfamideOFFSIDES
171IpratropiumOFFSIDES
172LasofoxifeneSIDER
173LeucovorinOFFSIDES
174LeuprolideOFFSIDES
175LinezolidOFFSIDES
176LisinoprilOFFSIDES
177MeperidineOFFSIDES
178MethocarbamolOFFSIDES
179MetoclopramideOFFSIDES
180MilrinoneOFFSIDES
181MinocyclineOFFSIDES
182Mometasone FuroateOFFSIDES
183MupirocinOFFSIDES
184NadololOFFSIDES
185NelfinavirOFFSIDES
186NicorandilSIDER
187Nitric OxideOFFSIDES
188NitrofurantoinOFFSIDES
189OctreotideCanada Vigilance: 1Canada Vigilance
OFFSIDES
190PaclitaxelOFFSIDES
191PalonosetronOFFSIDES
192PamidronateOFFSIDES
193PhenelzineOFFSIDES
194PheniramineOFFSIDES
195PhenobarbitalOFFSIDES
196PhenprocoumonOFFSIDES
197PrednisoneOFFSIDES
198RibavirinOFFSIDES
199SaquinavirOFFSIDES
200SaridonOFFSIDES
201SimethiconeOFFSIDES
202Sodium picosulfateOFFSIDES
203SulfanilamideOFFSIDES
204SumatriptanOFFSIDES
205TerazosinOFFSIDES
206TetracyclineOFFSIDES
207TicarcillinOFFSIDES
208Tolterodine TartrateOFFSIDES
209TremorineOFFSIDES
210TretinoinOFFSIDES
211TrimebutineOFFSIDES
212ZidovudineOFFSIDES
213alfuzosinOFFSIDES
214anagrelideOFFSIDES
215cefpodoxime proxetilOFFSIDES
216cilnidipineOFFSIDES
217cisatracuriumOFFSIDES
218cyclobenzaprineOFFSIDES
219efavirenzOFFSIDES
220eprosartanOFFSIDES
221gadodiamideOFFSIDES
222gadoversetamideOFFSIDES
223gliquidoneOFFSIDES
224miglitolOFFSIDES
225nefazodoneOFFSIDES
226nelarabineOFFSIDES
227polaprezincOFFSIDES
228polystyrene sulfonic acidOFFSIDES
229tazaroteneOFFSIDES
230tegaserodCanada Vigilance: 1Canada Vigilance
231tegaserodOFFSIDES
232temsirolimusOFFSIDES
233tipranavirOFFSIDES
234zafirlukastOFFSIDES
235zopicloneOFFSIDES
Similar ADE(s)
NameSemantic Similarity
1Fecal Incontinence36%
2Pruritus Ani33.3%
3Proctitis32.4%
4Cecal Diseases28.5%
5Colonic Diseases28.5%
6Ileal Diseases28.5%
7Intestinal Obstruction28.5%
8Intestinal Perforation28.5%
9Jejunal Diseases28.5%
10Pneumatosis Cystoides Intestinalis28.5%
11Cronkhite-Canada Syndrome28.5%
12Intestinal Polyposis28.5%
13Dysentery27.3%
14Enteritis27.3%
15Enterocolitis27.3%
16Inflammatory Bowel Diseases27.3%
17Hemorrhoids24.9%
18Rectocele24.3%
19Rectal Prolapse24.1%
20Rectal Fistula22.9%
21Anal Fistula22.9%
22Anus Neoplasms22.8%
23Colorectal Neoplasms22.7%
24Esophageal Diseases22.7%
25Gastroenteritis22.7%
26Stomach Diseases22.7%
27Duodenal Obstruction22.5%
28Duodenitis20.5%
29Ileitis20.5%
30Erosive Duodenitis20.5%
31Intestinal Diseases, Parasitic20.5%
32Proctocolitis20.2%
33Colitis19.5%
34Duodenogastric Reflux19.5%
35Peptic Ulcer19.5%
36Zollinger-Ellison syndrome19.1%
37Mesenteric vascular insufficiency18.7%
38Intestinal Atresia18.4%
39Mesenteric Vascular Occlusion18.4%
40Intestinal Fistula18.3%
41Enterocutaneous Fistula18.3%
42Intestinal Neoplasms18%
43Colonic Diseases, Functional16.8%
44Fecal Impaction16.8%
45Intussusception16.8%
46Megacolon16.8%
47Ileus16.8%
48Meconium ileus16.8%
49Esophagitis16.4%
50Gastritis16.4%
51Crohn Disease16%
52Enterocolitis, Neutropenic16%
53Necrotizing Enterocolitis16%
54Gastrointestinal Neoplasms15.3%
55Biliary Tract Diseases15.3%
56Liver diseases15.3%
57Pancreatic Diseases15.3%
58Gastrointestinal Hemorrhage15.1%
59Tuberculosis, Gastrointestinal14.8%
60Appendicitis14.7%
61Cecal Neoplasms14.4%
62Duodenal Neoplasms14.4%
63Rectal Neoplasms13.7%
64Pouchitis13.5%
65Colonic Pseudo-Obstruction12.9%
66Duodenal Ulcer12.2%
67Peptic Ulcer Perforation12.2%
68Gastric ulcer12.2%
69Esophageal Stenosis12.2%
70Gastric Dilatation12.2%
71Gastric outlet obstruction12.2%
72Enterocolitis, Pseudomembranous12%
73pseudomembranous colitis12%
74Dysentery, Bacillary12%
75Stomach Neoplasms11.5%
76Afferent Loop Syndrome11.4%
77Celiac Disease11.4%
78Short Bowel Syndrome11.4%
79Sprue, Tropical11.4%
80Steatorrhea11.4%
81Sprue11.4%
82Intestinal Pseudo-Obstruction11.1%
83Irritable Bowel Syndrome11.1%
84Superior Mesenteric Artery Syndrome11.1%
85Neurogenic Bowel11.1%
86Esophageal and Gastric Varices10.9%
87Digestive System Neoplasms10.2%
88Esophageal Atresia10%
89Esophageal Neoplasms9.6%
90Appendiceal Neoplasms9.5%
91Colonic Neoplasms9.5%
92Colitis, Ischemic9.4%
93Sigmoid Neoplasms9.2%
94Adenomatous Polyposis Coli9.2%
95Giardiasis8.9%
96Esophageal Perforation8.8%
97Barrett Esophagus8.4%
98Deglutition Disorders8.4%
99Achlorhydria8.2%
100Gastric Antral Vascular Ectasia8.2%
101Gastrointestinal Stromal Tumors8.2%
102Peptic Ulcer Hemorrhage8.1%
103Gastroparesis8.1%
104Liver neoplasms7.7%
105Pancreatic Fistula7.6%
106Bile Duct Diseases7.6%
107Cholelithiasis7.6%
108Chylous Ascites7.6%
109Fatty Liver7.6%
110Hepatitis7.6%
111Portal Hypertension7.6%
112Liver Cirrhosis7.6%
113Pancreatic Insufficiency7.6%
114Pancreatitis7.6%
115Pneumoperitoneum7.6%
116Focal Nodular Hyperplasia7.6%
117Hepatic Insufficiency7.6%
118Steatohepatitis7.6%
119Esophageal motility disorders7.2%
120Mallory-Weiss Syndrome7.2%
121Pyloric Stenosis7.2%
122Peutz-Jeghers Syndrome6.9%
123Lactose Intolerance6.8%
124Melena6.2%
125Peritoneal Neoplasms6.1%
126Hematemesis6.1%
127Cholecystolithiasis5.5%
128Liver Diseases, Parasitic5.4%
129Hepatic Veno-Occlusive Disease5.1%
130Pancreatic Cyst5.1%
131Peliosis Hepatis5.1%
132Hepatopulmonary Syndrome5.1%
133Pancreatic Neoplasm5.1%
134Anus, Imperforate5%
135Hemoperitoneum5%
136Hepatomegaly5%
137Mesenteric Panniculitis5%
138Panniculitis, Peritoneal5%
139Peritonitis5%
140Peritoneal Fibrosis5%
141Encapsulating Peritoneal Sclerosis5%
142Anorectal Malformations5%
143Cryptosporidiosis5%
144Biliary Fistula5%
145Gastric Fistula5%
146Hepatic Vein Thrombosis4.9%
147Liver Abscess4.9%
148Budd-Chiari Syndrome4.9%
149Bile Duct Neoplasms4.9%
150gallbladder neoplasm4.9%
151Biliary cirrhosis4.9%
152Diverticulitis4.8%
153Dumping Syndrome4.8%
154Esophageal Achalasia4.8%
155Choledochal Cyst4.7%
156Choledocholithiasis4.3%
157Cholangitis4.1%
158Cholecystitis4.1%
159Cholestasis4.1%
160Common Bile Duct Diseases4.1%
161Fatty Liver, Alcoholic4.1%
162Hepatitis, Alcoholic4.1%
163Hepatitis, Chronic4.1%
164Liver Cirrhosis, Alcoholic4.1%
165Liver Failure4.1%
166Pancreatitis, Chronic4.1%
167Non-alcoholic Fatty Liver Disease4.1%
168Chronic active hepatitis4.1%
169Chemical and Drug Induced Liver Injury3.9%
170Hepatorenal Syndrome3.7%
171Diverticulum3.7%
172Diverticulosis3.7%
173Hepatocellular Adenoma3.3%
174Cystic Fibrosis3.1%
175Porphyrias, Hepatic3%
176Congenital Hyperinsulinism3%
177Hepatitis, Animal2.9%
178Hepatitis, Viral, Human2.9%
179Liver Abscess, Amebic2.8%
180Liver Neoplasms, Experimental2.8%
181Liver Cirrhosis, Experimental2.7%
182Pancreatic Pseudocyst2.7%
183Pancreatitis, Alcoholic2.7%
184Laryngopharyngeal Reflux2.5%
185Cholestasis, Extrahepatic2.4%
186Biliary Dyskinesia2.4%
187Cholangitis, Sclerosing2.4%
188Liver Failure, Acute2.4%
189Acalculous Cholecystitis2.4%
190End Stage Liver Disease2.4%
191Fascioliasis2.1%
192Echinococcosis, Hepatic2.1%
193Chemical and Drug Induced Liver Injury, Chronic2.1%
194Reye Syndrome2%
195Carcinoma, Pancreatic Ductal2%
196Autoimmune hepatitis1.7%
197Nesidioblastosis1.6%
198Variegate Porphyria1.6%
199Acute intermittent porphyria1.6%
200Porphyria Cutanea Tarda1.6%
201Hepatitis B, Chronic1.6%
202Hepatitis C, Chronic1.6%
203Massive Hepatic Necrosis1.6%
204Emphysematous Cholecystitis1.6%
205Sphincter of Oddi Dysfunction1.6%
206CREST Syndrome1.4%
207insulinoma1.4%
208Gastrinoma1.4%
209Glucagonoma1.4%
210Zellweger Syndrome1.3%
211Hepatitis, Viral, Animal1.3%
212Hepatitis E1.3%
213Hepatitis B1.2%
214Hepatitis C1.2%
215Hepatitis A1.2%
216Hepatolenticular Degeneration1.2%
217Hepatic Encephalopathy1.2%
218Vipoma1.2%
219Rift Valley Fever0.5%
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