MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Liver Cirrhosis

(UMLS:C0023890)

Definition:: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
UMLS ID:: C0023890
MeSH ID:: D008103

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.630

Synonym(s)

Liver Cirrhosis

CIRRHOSIS

CIRRHOSIS OF LIVER

CL - Cirrhosis of liver

Cirrhosis

Cirrhosis (Liver)

Cirrhosis (of);liver

Cirrhosis of liver

Cirrhosis of liver, NOS

10.

Cirrhosis of the Liver

11.

HEPATIC CIRRHOSIS

12.

Hepatic cirrhosis

13.

Hepatic cirrhosis, NOS

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-Naphthylisothiocyanate	21037076 26921287	CTD
2	15-deoxy-delta(12,14)-prostaglandin J2	19429239	CTD
3	2,3,4,2',3',4'-hexachlorobiphenyl	28163111	CTD
4	3,4,5,3',4'-pentachlorobiphenyl	28163111	CTD
5	3,5-diethoxycarbonyl-1,4-dihydrocollidine	30825315	CTD
6	3-methylquercetin	27151496	CTD
7	4,4'-diaminodiphenylmethane	26396155	CTD
8	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	21316382	CTD
9	Acetaminophen	9183313	CTD
10	Acitretin	2147707 11922592	CTD
11	Alcohols	View details 52258 920871 2920047 5581500 7130740 10803778 15289165 22149461 24239723 28419832 30543783	CTD
12	Aldosterone	15613622 25204689	CTD
13	Amiodarone	View details 3941726 3962737 3970484 6326931 7514624 7626301 8436346 9594610 16149155 16284489 17201899 17939344 19565059 20175957	CTD
14	Arsenicals	10930056 11836136	CTD
15	Ascorbic Acid	22149461 24239723	CTD
16	Azathioprine	9810203 16397313	CTD
17	Azoxymethane	20197374	CTD
18	Benzbromarone	9392688	CTD
19	Bilirubin	17977396	CTD
20	Carbon Tetrachloride	View details 2025881 2583690 3674465 3966663 5485113 6301521 7248170 7445978 8187048 8878782 9927535 11014614 11144963 11408273 11903743 11999218 12055599 12800243 16221502 16239168 16943688 17157831 17174718 17334410 18045581 19747501 20371262 21055838 21278145 22223197 22363424 22386810 22683883 22705329 22989100 23146695 23262250 23500774 23548910 23958495 25303780 25858767 25912033 26297989 26396155 26443840 26778414 26853152 26882442 26921287 27042213 27151496 27268753 27396813 27452039 27477297 27939986 28935427 29127188 29974145 29987408 30010033 30502394 30543783 30703375 30719803 31150632	CTD
21	Chenodeoxycholic Acid	3470420	CTD
22	Chlordecone	26853152	CTD
23	Chloroform	21760731	CTD
24	Cholic Acid	26004525	CTD
25	Choline	View details 17825453 20196952 28163111 29097836 30745416	CTD
26	Clodronic Acid	27022031	CTD
27	Colchicine	23146695	CTD
28	Copper	7849148 20946909	CTD
29	Cyclophosphamide	17786148	CTD
30	D-Galactosamine	27836788 27876602	CTD
31	Deferoxamine	27095094	CTD
32	Diclofenac	1582111	CTD
33	Diethylnitrosamine	View details 18407596 18522880 18665156 19638242 19874807 20032147 23288052 24511000 28804948 28935427 29127188	CTD
34	Diethylstilbestrol	12890826	CTD
35	Diltiazem	27095094	CTD
36	Dimethyl Fumarate	30703375	CTD
37	Dimethylnitrosamine	View details 12055599 19647758 23197195 23485615 25064540	CTD
38	Doxepin	6326931	CTD
39	Doxorubicin	22712078 29133031	CTD
40	Enalapril	18765277 21664615	CTD
41	Epirubicin	22712078	CTD
42	Etretinate	11922592	CTD
43	Eucalyptol	26023714	CTD
44	FR 167653	17334410	CTD
45	Fenofibrate	15745090	CTD
46	Floxuridine	2877311	CTD
47	Fluorouracil	12909244	CTD
48	Furosemide	634773 759067	CTD
49	Genistein	27876602	CTD
50	Gentamicins	634773	CTD
51	Glatiramer Acetate	17038628	CTD
52	Grape Seed Extract	21605584	CTD
53	Griseofulvin	12735108	CTD
54	Halothane	6628838	CTD
55	Hesperidin	28935427	CTD
56	Hydrochloric Acid	16984587	CTD
57	Imatinib Mesylate	21316382	CTD
58	Isoniazid	448941 1150039 7406100	CTD
59	Lamivudine	View details 10952249 11084057 11738102 12616454 12681069 14552720 16481275 16960342 19912686	CTD
60	Leflunomide	11083289	CTD
61	Lithocholic Acid	16436656	CTD
62	Losartan	18765277	CTD
63	Lovastatin	22712078	CTD
64	Luteolin	19747501	CTD
65	Melatonin	16098091 26286521	CTD
66	Melitten	21969711	CTD
67	Menthol	14731143	CTD
68	Mercaptopurine	169114	CTD
69	Mesalamine	29738702	CTD
70	Methionine	View details 17825453 20196952 28163111 29097836 30745416	CTD
71	Methotrexate	View details 52258 169114 200767 288556 845977 870655 899789 920871 1361285 1390139 1629819 1649062 1880254 2297495 2445154 2566230 2920047 3179204 3195601 3629206 3653467 3704718 4648805 4733959 4750546 4783020 4853200 5015292 5028402 5108642 5350402 5350403 5501902 5548839 5581500 5695945 6183903 7130740 7387883 7423637 7722021 7741497 7857846 7880186 7921763 8250989 8308218 8434456 8452577 8667468 8864370 8990864 9193771 11083289 11167689 11641084 14642249 14673972 14871278 14986274 15787813 16443079 16679477 16696812 17498249 19273538 20801541	CTD
72	Methyldopa	424836 851765 946400	CTD
73	Methyltestosterone	4117807	CTD
74	Nandrolone Decanoate	18408615	CTD
75	Nimodipine	27095094	CTD
76	Nitrofurantoin	View details 482863 1153946 7871583 14983581	CTD
77	Nizatidine	7769203	CTD
78	Octreotide	25338529	CTD
79	Oleanolic Acid	21172400	CTD
80	Olmesartan Medoxomil	18501344	CTD
81	Orlistat	17404856	CTD
82	Papaverine	3949106	CTD
83	Penicillamine	20946909	CTD
84	Pentoxifylline	1976392	CTD
85	Perindopril	12076858	CTD
86	Phenobarbital	View details 2025881 6301521 7248170 8187048 9927535 11014614 11144963 21047994	CTD
87	Phenprocoumon	1963177 20221993	CTD
88	Plethoryl	2523055	CTD
89	Polychlorinated Dibenzodioxins	View details 24154488 27562557 27713108 28238261 28302560	CTD
90	Polyvinyl Chloride	View details 11679801 12499459 12958735 14651027 15289165 15354062	CTD
91	Praziquantel	18473419	CTD
92	Primidone	3997653	CTD
93	Propranolol	4007042 6327487 11871761	CTD
94	Quercetin	22989100 26286521	CTD
95	Resveratrol	View details 22086758 23262250 25064540 26286521 27345520 30745416	CTD
96	Ribavirin	15778976 16169782	CTD
97	Ritonavir	9786823	CTD
98	Rivaroxaban	30719803	CTD
99	Rosiglitazone	18473419 18991162	CTD
100	S-Adenosylmethionine	8878782	CTD
101	Scopolamine	20197374	CTD
102	Serotonin	28623179	CTD
103	Silymarin	View details 17213517 21316382 22386810 22705329	CTD
104	Simvastatin	11281188	CTD
105	Sirolimus	20511674	CTD
106	Spironolactone	25204689	CTD
107	Streptozocin	26286521	CTD
108	Tamoxifen	10023952 11139682 11843860	CTD
109	Terbinafine	20816994	CTD
110	Thalidomide	16943688 17174718	CTD
111	Thiabendazole	2721325	CTD
112	Thiamethoxam	29197058	CTD
113	Thioacetamide	View details 12909244 16098091 17258737 19822164 20957682 21251946 21969711 22223197 22285267 22863721 22899499 23408952 23411599 28181416 28560358 29133031 29738702 30138605	CTD
114	Thioctic Acid	21251946 29760339	CTD
115	Torsemide	1706990	CTD
116	Troglitazone	11281188	CTD
117	Ursodeoxycholic Acid	3470420 8713707	CTD
118	Verapamil	27095094	CTD
119	Vitamin A	View details 303561 636413 1470008 2324882 4810330 4843409 10750659 11012474 16256175 17151585 18755329	CTD
120	Vitamin D	29653100	CTD
121	acetovanillone	29760339	CTD
122	acetylsalicylic acid lysinate	8746055	CTD
123	adefovir dipivoxil	16611191 17087951 19912686	CTD
124	adefovir	17409599	CTD
125	allyl alcohol	26396155	CTD
126	anandamide	11433348	CTD
127	andrographolide	20946909	CTD
128	arsenic acid	18296743	CTD
129	benzarone	7776854	CTD
130	betulinic acid	22285267	CTD
131	caryophyllene	29097836	CTD
132	chloroquine diphosphate	29133031	CTD
133	chrysin	26297989	CTD
134	cobaltiprotoporphyrin	19554654	CTD
135	delphinidin	20371262	CTD
136	dimerumic acid	24036144	CTD
137	epalrestat	28204799	CTD
138	epigallocatechin gallate	25955525	CTD
139	gamma-mangostin	30502394	CTD
140	geraniol	26004525 26695085	CTD
141	halofuginone	17180598	CTD
142	lanreotide	19874807	CTD
143	leukadherin-1	26921287	CTD
144	manganese dioxide	23702825	CTD
145	methyl ferulate	30543783	CTD
146	mustard oil	24036144	CTD
147	obeticholic acid	30745416	CTD
148	ochratoxin A	16857307	CTD
149	perfluorooctanoic acid	30711707	CTD
150	perhexiline maleate	View details 213349 6572824 6888970 7158236 7342619	CTD
151	platycodin D	23116642	CTD
152	propylene dichloride	2744274	CTD
153	puerarin	16426832 23146695 23500774	CTD
154	schizandrin B	31150632	CTD
155	sodium arsenite	21134390 29459688	CTD
156	tempol	25204689	CTD
157	tetramethylpyrazine	27477297	CTD
158	titanium dioxide	19156710	CTD
159	ursolic acid	21172400	CTD
160	zinc protoporphyrin	23704825	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Fatty Liver	42.9%
2	Hepatitis	42.9%
3	Portal Hypertension	42.9%
4	Focal Nodular Hyperplasia	42.9%
5	Hepatic Insufficiency	42.9%
6	Steatohepatitis	42.9%
7	Hepatitis, Chronic	31%
8	Liver Failure	31%
9	Non-alcoholic Fatty Liver Disease	31%
10	Chronic active hepatitis	31%
11	Fatty Liver, Alcoholic	30.1%
12	Hepatitis, Alcoholic	30.1%
13	Liver Diseases, Parasitic	30%
14	Hepatic Veno-Occlusive Disease	28.6%
15	Peliosis Hepatis	28.6%
16	Hepatopulmonary Syndrome	28.6%
17	Liver neoplasms	28.1%
18	Hepatomegaly	27.9%
19	Hepatic Vein Thrombosis	27.4%
20	Liver Abscess	27.4%
21	Budd-Chiari Syndrome	27.4%
22	Esophageal and Gastric Varices	27.3%
23	Liver Failure, Acute	25.4%
24	End Stage Liver Disease	25.4%
25	Biliary Tract Diseases	23.1%
26	Gastrointestinal Diseases	23.1%
27	Pancreatic Diseases	23.1%
28	Massive Hepatic Necrosis	22.7%
29	Hepatitis, Animal	22%
30	Hepatitis, Viral, Human	22%
31	Chemical and Drug Induced Liver Injury	21.4%
32	Hepatorenal Syndrome	20.5%
33	Liver Abscess, Amebic	20.3%
34	Biliary cirrhosis	18.8%
35	Hepatitis B, Chronic	18.8%
36	Hepatitis C, Chronic	18.8%
37	Autoimmune hepatitis	17.2%
38	Porphyrias, Hepatic	16.4%
39	Hepatocellular Adenoma	16%
40	Fascioliasis	15.5%
41	Echinococcosis, Hepatic	15.4%
42	Chemical and Drug Induced Liver Injury, Chronic	15.3%
43	Reye Syndrome	15.1%
44	Liver Cirrhosis, Alcoholic	15.1%
45	Digestive System Neoplasms	15%
46	Bile Duct Diseases	14.3%
47	Cholelithiasis	14.3%
48	Chylous Ascites	14.3%
49	Esophageal Diseases	14.3%
50	Gastroenteritis	14.3%
51	Intestinal Diseases	14.3%
52	Pancreatic Insufficiency	14.3%
53	Pancreatitis	14.3%
54	Pneumoperitoneum	14.3%
55	Stomach Diseases	14.3%
56	Gastrointestinal Neoplasms	14%
57	Zollinger-Ellison syndrome	13.9%
58	Pancreatic Fistula	13.9%
59	Dysentery	13.6%
60	Enteritis	13.6%
61	Enterocolitis	13.6%
62	Esophagitis	13.6%
63	Gastritis	13.6%
64	Inflammatory Bowel Diseases	13.6%
65	Cholecystolithiasis	13.6%
66	Hepatitis, Viral, Animal	13.5%
67	Liver Neoplasms, Experimental	13.5%
68	Hepatitis E	13%
69	Hepatitis B	12.8%
70	Hepatitis C	12.8%
71	Proctocolitis	12.7%
72	Hepatitis A	12.7%
73	Hepatic Encephalopathy	12.5%
74	Duodenitis	12.4%
75	Ileitis	12.4%
76	Erosive Duodenitis	12.4%
77	Colitis	12.4%
78	Duodenogastric Reflux	12.4%
79	Peptic Ulcer	12.4%
80	Proctitis	12.4%
81	Choledocholithiasis	12.4%
82	Mesenteric vascular insufficiency	12.3%
83	Bile Duct Neoplasms	12.1%
84	gallbladder neoplasm	12.1%
85	Intestinal Neoplasms	12.1%
86	Stomach Neoplasms	12.1%
87	Esophageal Atresia	12.1%
88	Intestinal Atresia	12.1%
89	Mesenteric Vascular Occlusion	12.1%
90	Intestinal Fistula	12%
91	Enterocutaneous Fistula	12%
92	Variegate Porphyria	11.9%
93	Acute intermittent porphyria	11.9%
94	Porphyria Cutanea Tarda	11.9%
95	Colorectal Neoplasms	11.7%
96	Crohn Disease	11.1%
97	Duodenal Obstruction	11.1%
98	Peritoneal Neoplasms	11.1%
99	Enterocolitis, Neutropenic	11.1%
100	Necrotizing Enterocolitis	11.1%
101	Pouchitis	11%
102	Cecal Neoplasms	10.9%
103	Duodenal Neoplasms	10.9%
104	Rectal Fistula	10.6%
105	Anal Fistula	10.6%
106	Duodenal Ulcer	10.5%
107	Peptic Ulcer Perforation	10.5%
108	Gastric ulcer	10.5%
109	Cecal Diseases	10.3%
110	Cholangitis	10.3%
111	Cholecystitis	10.3%
112	Cholestasis	10.3%
113	Colonic Diseases	10.3%
114	Common Bile Duct Diseases	10.3%
115	Esophageal Stenosis	10.3%
116	Ileal Diseases	10.3%
117	Intestinal Obstruction	10.3%
118	Intestinal Perforation	10.3%
119	Jejunal Diseases	10.3%
120	Pneumatosis Cystoides Intestinalis	10.3%
121	Rectal Diseases	10.3%
122	Gastric Dilatation	10.3%
123	Pancreatitis, Chronic	10.3%
124	Gastric outlet obstruction	10.3%
125	Cronkhite-Canada Syndrome	10.3%
126	Intestinal Polyposis	10.3%
127	Gastrointestinal Stromal Tumors	10.1%
128	Esophageal Neoplasms	10.1%
129	Anus Neoplasms	9.8%
130	Sigmoid Neoplasms	9.8%
131	Choledochal Cyst	9.7%
132	Appendiceal Neoplasms	9.7%
133	Colonic Neoplasms	9.7%
134	Rectal Neoplasms	9.7%
135	Colonic Pseudo-Obstruction	9.6%
136	Pancreatic Cyst	9.5%
137	Anus, Imperforate	9.3%
138	Gastrointestinal Hemorrhage	9.3%
139	Hemoperitoneum	9.3%
140	Mesenteric Panniculitis	9.3%
141	Pancreatic Neoplasm	9.3%
142	Panniculitis, Peritoneal	9.3%
143	Peritonitis	9.3%
144	Peritoneal Fibrosis	9.3%
145	Encapsulating Peritoneal Sclerosis	9.3%
146	Anorectal Malformations	9.3%
147	Appendicitis	9.2%
148	Biliary Fistula	9.2%
149	Gastric Fistula	9.2%
150	Tuberculosis, Gastrointestinal	9.1%
151	Cholestasis, Extrahepatic	8.5%
152	Biliary Dyskinesia	8.5%
153	Cholangitis, Sclerosing	8.5%
154	Colonic Diseases, Functional	8.5%
155	Esophageal motility disorders	8.5%
156	Fecal Incontinence	8.5%
157	Fecal Impaction	8.5%
158	Intussusception	8.5%
159	Mallory-Weiss Syndrome	8.5%
160	Megacolon	8.5%
161	Pyloric Stenosis	8.5%
162	Acalculous Cholecystitis	8.5%
163	Ileus	8.5%
164	Meconium ileus	8.5%
165	Enterocolitis, Pseudomembranous	8.3%
166	pseudomembranous colitis	8.3%
167	Dysentery, Bacillary	8.3%
168	Colitis, Ischemic	8%
169	Esophageal Achalasia	7.6%
170	Anal Fissure	7.6%
171	Intestinal Pseudo-Obstruction	7.6%
172	Irritable Bowel Syndrome	7.6%
173	Superior Mesenteric Artery Syndrome	7.6%
174	Emphysematous Cholecystitis	7.6%
175	Neurogenic Bowel	7.6%
176	Sphincter of Oddi Dysfunction	7.6%
177	Anal Ulcer	7.6%
178	Adenomatous Polyposis Coli	7.5%
179	Esophageal Perforation	7.3%
180	Intestinal Diseases, Parasitic	7.3%
181	Zellweger Syndrome	7.2%
182	Barrett Esophagus	7%
183	Deglutition Disorders	7%
184	Achlorhydria	6.8%
185	Pancreatic Pseudocyst	6.8%
186	Gastric Antral Vascular Ectasia	6.8%
187	Peptic Ulcer Hemorrhage	6.7%
188	Gastroparesis	6.7%
189	Pancreatitis, Alcoholic	6.7%
190	Hepatolenticular Degeneration	6.6%
191	Rift Valley Fever	6.6%
192	Hemorrhoids	5.7%
193	Cystic Fibrosis	5.7%
194	Afferent Loop Syndrome	5.6%
195	Celiac Disease	5.6%
196	Short Bowel Syndrome	5.6%
197	Sprue, Tropical	5.6%
198	Steatorrhea	5.6%
199	Rectocele	5.6%
200	Sprue	5.6%
201	Diverticulitis	5.6%
202	Dumping Syndrome	5.6%
203	Rectal Prolapse	5.6%
204	Congenital Hyperinsulinism	5.5%
205	Melena	5.1%
206	Pruritus Ani	5%
207	Hematemesis	5%
208	Carcinoma, Pancreatic Ductal	4.9%
209	Laryngopharyngeal Reflux	4.8%
210	insulinoma	4.6%
211	Gastrinoma	4.6%
212	Glucagonoma	4.6%
213	Giardiasis	4.3%
214	Diverticulum	4.2%
215	Diverticulosis	4.2%
216	Vipoma	4%
217	Nesidioblastosis	4%
218	Peutz-Jeghers Syndrome	3.4%
219	Lactose Intolerance	3.3%
220	Cryptosporidiosis	2.4%
221	CREST Syndrome	2.1%

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