MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Focal Nodular Hyperplasia

(UMLS:C0333980)

Definition:: Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.
UMLS ID:: C0333980
MeSH ID:: D020518

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.270

Synonym(s)

Focal Nodular Hyperplasia

Focal nodular hyperplasia

focal hyperplasia nodular

focal nodular hyperplasia

nodular focal hyperplasia

nodular hyperplasia focal

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Norgestrel	FAERS: 62 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	NuvaRing	FAERS: 9		OFFSIDES US FAERS
3	Alendronate	FAERS: 8		US FAERS
4	Cabergoline	FAERS: 4		OFFSIDES US FAERS
5	Isotretinoin	FAERS: 4		US FAERS
6	Ortho Evra	FAERS: 3		US FAERS
7	Aripiprazole	FAERS: 2		US FAERS
8	Ethinyl Estradiol-Norgestrel Combination	FAERS: 2		US FAERS
9	Leucovorin	FAERS: 2		US FAERS
10	etonogestrel	FAERS: 2		US FAERS
11	Cyclophosphamide	FAERS: 1		US FAERS
12	Danazol	FAERS: 1	16710600	CTD OFFSIDES US FAERS
13	Desogestrel	FAERS: 1		US FAERS
14	Desogestrel	FAERS: 1		OFFSIDES US FAERS
15	Dimethyl Fumarate	FAERS: 1		US FAERS
16	Erythromycin	FAERS: 1		US FAERS
17	Finasteride	FAERS: 1		US FAERS
18	Fingolimod Hydrochloride	FAERS: 1		US FAERS
19	Fluconazole	FAERS: 1		US FAERS
20	Imatinib Mesylate	FAERS: 1		US FAERS
21	Itraconazole	FAERS: 1		US FAERS
22	Losartan	FAERS: 1		US FAERS
23	Mesalamine	FAERS: 1		US FAERS
24	Oxcarbazepine	FAERS: 1		US FAERS
25	Qlaira	FAERS: 1		US FAERS
26	Rivaroxaban	FAERS: 1		US FAERS
27	Sitagliptin Phosphate	FAERS: 1		US FAERS
28	Teriparatide	FAERS: 1		US FAERS
29	Thioguanine	FAERS: 1	15316320 17894846 17943403	CTD OFFSIDES US FAERS
30	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
31	apixaban	FAERS: 1		US FAERS
32	exemestane	FAERS: 1		US FAERS
33	norgestimate, ethinyl estradiol drug combination	FAERS: 1		US FAERS
34	rofecoxib	FAERS: 1		US FAERS
35	rotigotine	FAERS: 1		US FAERS
36	Azathioprine			OFFSIDES
37	Bortezomib			OFFSIDES
38	Busulfan		15886082	CTD OFFSIDES
39	Caspofungin			OFFSIDES
40	Caspofungin			OFFSIDES
41	Didanosine			OFFSIDES
42	Dimethylnitrosamine		6428851	CTD
43	Etoposide			OFFSIDES
44	Fluorouracil			OFFSIDES
45	Itraconazole		11606862	CTD
46	Leucovorin			OFFSIDES
47	Methotrexate			OFFSIDES
48	Nevirapine			OFFSIDES
49	Polychlorinated Biphenyls		6428851	CTD
50	Prednisone acetate			OFFSIDES
51	Pyrazinamide			OFFSIDES
52	Tetracycline			OFFSIDES
53	fludarabine phosphate			OFFSIDES
54	fludarabine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Fatty Liver	42.9%
2	Hepatitis	42.9%
3	Portal Hypertension	42.9%
4	Liver Cirrhosis	42.9%
5	Hepatic Insufficiency	42.9%
6	Steatohepatitis	42.9%
7	Biliary cirrhosis	33.9%
8	Hepatitis, Chronic	31%
9	Liver Failure	31%
10	Non-alcoholic Fatty Liver Disease	31%
11	Chronic active hepatitis	31%
12	Fatty Liver, Alcoholic	30.1%
13	Hepatitis, Alcoholic	30.1%
14	Liver Cirrhosis, Alcoholic	30.1%
15	Liver Diseases, Parasitic	30%
16	Hepatic Veno-Occlusive Disease	28.6%
17	Peliosis Hepatis	28.6%
18	Hepatopulmonary Syndrome	28.6%
19	Liver neoplasms	28.1%
20	Hepatomegaly	27.9%
21	Hepatic Vein Thrombosis	27.4%
22	Liver Abscess	27.4%
23	Budd-Chiari Syndrome	27.4%
24	Esophageal and Gastric Varices	27.3%
25	Liver Failure, Acute	25.4%
26	End Stage Liver Disease	25.4%
27	Biliary Tract Diseases	23.1%
28	Gastrointestinal Diseases	23.1%
29	Pancreatic Diseases	23.1%
30	Massive Hepatic Necrosis	22.7%
31	Hepatitis, Animal	22%
32	Hepatitis, Viral, Human	22%
33	Chemical and Drug Induced Liver Injury	21.4%
34	Hepatorenal Syndrome	20.5%
35	Liver Cirrhosis, Experimental	20.5%
36	Liver Abscess, Amebic	20.3%
37	Hepatitis B, Chronic	18.8%
38	Hepatitis C, Chronic	18.8%
39	Autoimmune hepatitis	17.2%
40	Porphyrias, Hepatic	16.4%
41	Hepatocellular Adenoma	16%
42	Fascioliasis	15.5%
43	Echinococcosis, Hepatic	15.4%
44	Chemical and Drug Induced Liver Injury, Chronic	15.3%
45	Reye Syndrome	15.1%
46	Digestive System Neoplasms	15%
47	Bile Duct Diseases	14.3%
48	Cholelithiasis	14.3%
49	Chylous Ascites	14.3%
50	Esophageal Diseases	14.3%
51	Gastroenteritis	14.3%
52	Intestinal Diseases	14.3%
53	Pancreatic Insufficiency	14.3%
54	Pancreatitis	14.3%
55	Pneumoperitoneum	14.3%
56	Stomach Diseases	14.3%
57	Gastrointestinal Neoplasms	14%
58	Zollinger-Ellison syndrome	13.9%
59	Pancreatic Fistula	13.9%
60	Dysentery	13.6%
61	Enteritis	13.6%
62	Enterocolitis	13.6%
63	Esophagitis	13.6%
64	Gastritis	13.6%
65	Inflammatory Bowel Diseases	13.6%
66	Cholecystolithiasis	13.6%
67	Hepatitis, Viral, Animal	13.5%
68	Liver Neoplasms, Experimental	13.5%
69	Hepatitis E	13%
70	Hepatitis B	12.8%
71	Hepatitis C	12.8%
72	Proctocolitis	12.7%
73	Hepatitis A	12.7%
74	Hepatic Encephalopathy	12.5%
75	Duodenitis	12.4%
76	Ileitis	12.4%
77	Erosive Duodenitis	12.4%
78	Colitis	12.4%
79	Duodenogastric Reflux	12.4%
80	Peptic Ulcer	12.4%
81	Proctitis	12.4%
82	Choledocholithiasis	12.4%
83	Mesenteric vascular insufficiency	12.3%
84	Bile Duct Neoplasms	12.1%
85	gallbladder neoplasm	12.1%
86	Intestinal Neoplasms	12.1%
87	Stomach Neoplasms	12.1%
88	Esophageal Atresia	12.1%
89	Intestinal Atresia	12.1%
90	Mesenteric Vascular Occlusion	12.1%
91	Intestinal Fistula	12%
92	Enterocutaneous Fistula	12%
93	Variegate Porphyria	11.9%
94	Acute intermittent porphyria	11.9%
95	Porphyria Cutanea Tarda	11.9%
96	Colorectal Neoplasms	11.7%
97	Crohn Disease	11.1%
98	Duodenal Obstruction	11.1%
99	Peritoneal Neoplasms	11.1%
100	Enterocolitis, Neutropenic	11.1%
101	Necrotizing Enterocolitis	11.1%
102	Pouchitis	11%
103	Cecal Neoplasms	10.9%
104	Duodenal Neoplasms	10.9%
105	Rectal Fistula	10.6%
106	Anal Fistula	10.6%
107	Duodenal Ulcer	10.5%
108	Peptic Ulcer Perforation	10.5%
109	Gastric ulcer	10.5%
110	Cecal Diseases	10.3%
111	Cholangitis	10.3%
112	Cholecystitis	10.3%
113	Cholestasis	10.3%
114	Colonic Diseases	10.3%
115	Common Bile Duct Diseases	10.3%
116	Esophageal Stenosis	10.3%
117	Ileal Diseases	10.3%
118	Intestinal Obstruction	10.3%
119	Intestinal Perforation	10.3%
120	Jejunal Diseases	10.3%
121	Pneumatosis Cystoides Intestinalis	10.3%
122	Rectal Diseases	10.3%
123	Gastric Dilatation	10.3%
124	Pancreatitis, Chronic	10.3%
125	Gastric outlet obstruction	10.3%
126	Cronkhite-Canada Syndrome	10.3%
127	Intestinal Polyposis	10.3%
128	Gastrointestinal Stromal Tumors	10.1%
129	Esophageal Neoplasms	10.1%
130	Anus Neoplasms	9.8%
131	Sigmoid Neoplasms	9.8%
132	Choledochal Cyst	9.7%
133	Appendiceal Neoplasms	9.7%
134	Colonic Neoplasms	9.7%
135	Rectal Neoplasms	9.7%
136	Colonic Pseudo-Obstruction	9.6%
137	Pancreatic Cyst	9.5%
138	Anus, Imperforate	9.3%
139	Gastrointestinal Hemorrhage	9.3%
140	Hemoperitoneum	9.3%
141	Mesenteric Panniculitis	9.3%
142	Pancreatic Neoplasm	9.3%
143	Panniculitis, Peritoneal	9.3%
144	Peritonitis	9.3%
145	Peritoneal Fibrosis	9.3%
146	Encapsulating Peritoneal Sclerosis	9.3%
147	Anorectal Malformations	9.3%
148	Appendicitis	9.2%
149	Biliary Fistula	9.2%
150	Gastric Fistula	9.2%
151	Tuberculosis, Gastrointestinal	9.1%
152	Cholestasis, Extrahepatic	8.5%
153	Biliary Dyskinesia	8.5%
154	Cholangitis, Sclerosing	8.5%
155	Colonic Diseases, Functional	8.5%
156	Esophageal motility disorders	8.5%
157	Fecal Incontinence	8.5%
158	Fecal Impaction	8.5%
159	Intussusception	8.5%
160	Mallory-Weiss Syndrome	8.5%
161	Megacolon	8.5%
162	Pyloric Stenosis	8.5%
163	Acalculous Cholecystitis	8.5%
164	Ileus	8.5%
165	Meconium ileus	8.5%
166	Enterocolitis, Pseudomembranous	8.3%
167	pseudomembranous colitis	8.3%
168	Dysentery, Bacillary	8.3%
169	Colitis, Ischemic	8%
170	Esophageal Achalasia	7.6%
171	Anal Fissure	7.6%
172	Intestinal Pseudo-Obstruction	7.6%
173	Irritable Bowel Syndrome	7.6%
174	Superior Mesenteric Artery Syndrome	7.6%
175	Emphysematous Cholecystitis	7.6%
176	Neurogenic Bowel	7.6%
177	Sphincter of Oddi Dysfunction	7.6%
178	Anal Ulcer	7.6%
179	Adenomatous Polyposis Coli	7.5%
180	Esophageal Perforation	7.3%
181	Intestinal Diseases, Parasitic	7.3%
182	Zellweger Syndrome	7.2%
183	Barrett Esophagus	7%
184	Deglutition Disorders	7%
185	Achlorhydria	6.8%
186	Pancreatic Pseudocyst	6.8%
187	Gastric Antral Vascular Ectasia	6.8%
188	Peptic Ulcer Hemorrhage	6.7%
189	Gastroparesis	6.7%
190	Pancreatitis, Alcoholic	6.7%
191	Hepatolenticular Degeneration	6.6%
192	Rift Valley Fever	6.6%
193	Hemorrhoids	5.7%
194	Cystic Fibrosis	5.7%
195	Afferent Loop Syndrome	5.6%
196	Celiac Disease	5.6%
197	Short Bowel Syndrome	5.6%
198	Sprue, Tropical	5.6%
199	Steatorrhea	5.6%
200	Rectocele	5.6%
201	Sprue	5.6%
202	Diverticulitis	5.6%
203	Dumping Syndrome	5.6%
204	Rectal Prolapse	5.6%
205	Congenital Hyperinsulinism	5.5%
206	Melena	5.1%
207	Pruritus Ani	5%
208	Hematemesis	5%
209	Carcinoma, Pancreatic Ductal	4.9%
210	Laryngopharyngeal Reflux	4.8%
211	insulinoma	4.6%
212	Gastrinoma	4.6%
213	Glucagonoma	4.6%
214	Giardiasis	4.3%
215	Diverticulum	4.2%
216	Diverticulosis	4.2%
217	Vipoma	4%
218	Nesidioblastosis	4%
219	Peutz-Jeghers Syndrome	3.4%
220	Lactose Intolerance	3.3%
221	Cryptosporidiosis	2.4%
222	CREST Syndrome	2.1%

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