MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Chemical and Drug Induced Liver Injury, Chronic

(UMLS:C4505492)

Definition:: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
UMLS ID:: C4505492
MeSH ID:: D056487

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.100.200

Classification 2:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.100.562.200|C25.723.260.200

Synonym(s)

Chemical and Drug Induced Liver Injury, Chronic

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetaminophen	19426721	CTD
2	Acitretin	11922592	CTD
3	Ajmaline	2568014	CTD
4	Alcohols	22525864	CTD
5	Amiodarone	16284489	CTD
6	Amitriptyline	3335290	CTD
7	Amoxicillin-Potassium Clavulanate Combination	8550991	CTD
8	Azathioprine	1600341 3902952	CTD
9	Diclofenac	2611118	CTD
10	Etretinate	11922592	CTD
11	Glycyrrhizic Acid	19426721	CTD
12	Isoniazid	1150039	CTD
13	enilconazole	29451352	CTD
14	matrine	19426721	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Mushroom Poisoning	21.3%
2	Fluoride Poisoning	20.3%
3	Food Poisoning	20.3%
4	Gas Poisoning	20.3%
5	Mycotoxicosis	20.3%
6	Plant Poisoning	20.3%
7	Anticholinergic Syndrome	20.3%
8	Serotonin Syndrome	20.3%
9	Organophosphate poisoning	20.3%
10	Propofol Infusion Syndrome	20.3%
11	Psychoses, Substance-Induced	17.6%
12	Bites and Stings	16.9%
13	Neurotoxicity Syndromes	16.9%
14	Akathisia, Drug-Induced	16.8%
15	Metabolic Side Effects of Drugs and Substances	16.4%
16	Water Intoxication	16.2%
17	Injection Site Reaction	16.2%
18	Arsenic Poisoning	16.2%
19	Infusion site reaction	16.2%
20	Fatty Liver, Alcoholic	16%
21	Hepatitis, Alcoholic	16%
22	Liver Cirrhosis, Alcoholic	16%
23	Fatty Liver	15.3%
24	Hepatitis	15.3%
25	Portal Hypertension	15.3%
26	Liver Cirrhosis	15.3%
27	Focal Nodular Hyperplasia	15.3%
28	Hepatic Insufficiency	15.3%
29	Steatohepatitis	15.3%
30	Dyskinesia, Drug-Induced	14.9%
31	Biliary cirrhosis	14.6%
32	Drug abuse	14.5%
33	Substance Dependence	14.5%
34	Substance-Related Disorders	14.5%
35	Drug Dependence	14.5%
36	Liver neoplasms	13.6%
37	Cadmium poisoning	13.3%
38	Carbon Monoxide Poisoning	13.3%
39	Ciguatera Poisoning	13.3%
40	Ergotism	13.3%
41	Lead Poisoning	13.3%
42	Mercury Poisoning	13.3%
43	Shellfish Poisoning	13.3%
44	Liver Diseases, Parasitic	12.7%
45	Hepatic Veno-Occlusive Disease	12.3%
46	Peliosis Hepatis	12.3%
47	Hepatopulmonary Syndrome	12.3%
48	Alcohol-Induced Disorders, Nervous System	12.3%
49	Hepatomegaly	12.2%
50	Hepatic Vein Thrombosis	12%
51	Liver Abscess	12%
52	Budd-Chiari Syndrome	12%
53	Cardiotoxicity	11.7%
54	Insect Bites and Stings	10.8%
55	Argyria	10.7%
56	Esophageal and Gastric Varices	10.7%
57	Manganese Poisoning	10.7%
58	Salmonella food poisoning	10.6%
59	Psychoses, Alcoholic	10.4%
60	Hepatorenal Syndrome	10.1%
61	Liver Abscess, Amebic	10%
62	Hepatitis, Chronic	10%
63	Liver Failure	10%
64	Non-alcoholic Fatty Liver Disease	10%
65	Chronic active hepatitis	10%
66	Alcohol Withdrawal Delirium	9.2%
67	Alcohol Withdrawal Seizures	9.1%
68	Neuroleptic Malignant Syndrome	8.9%
69	Drug Eruptions	8.9%
70	Biliary Tract Diseases	8.8%
71	Drug toxicity	8.8%
72	Gastrointestinal Diseases	8.8%
73	Pancreatic Diseases	8.8%
74	Poisoning	8.8%
75	Porphyrias, Hepatic	8.7%
76	Hepatitis, Animal	8.3%
77	Hepatitis, Viral, Human	8.3%
78	Tick Paralysis	8.2%
79	Marijuana Abuse	8.2%
80	Opioid-Related Disorders	8.2%
81	Nicotine Dependence	8.2%
82	Opioid abuse	8.2%
83	Phencyclidine Abuse	8.2%
84	Substance Abuse, Intravenous	8.2%
85	Substance Withdrawal Syndrome	8.2%
86	Tobacco Use Disorder	8.2%
87	Alcohol-Related Disorders	8.2%
88	Amphetamine-Related Disorders	8.2%
89	Cocaine-Related Disorders	8.2%
90	Drug Overdose	8.1%
91	Liver Cirrhosis, Experimental	8%
92	Mercury Poisoning, Nervous System	7.9%
93	Lead Poisoning, Nervous System	7.9%
94	Hepatitis B, Chronic	7.7%
95	Hepatitis C, Chronic	7.7%
96	Botulism	7.7%
97	MPTP Poisoning	7.6%
98	Hepatocellular Adenoma	7.5%
99	Liver Failure, Acute	7.4%
100	End Stage Liver Disease	7.4%
101	Zollinger-Ellison syndrome	7.1%
102	Digestive System Neoplasms	7%
103	Neonatal Abstinence Syndrome	6.9%
104	Chemical and Drug Induced Liver Injury	6.9%
105	Gastrointestinal Neoplasms	6.8%
106	Pancreatic Fistula	6.8%
107	Fascioliasis	6.7%
108	Echinococcosis, Hepatic	6.7%
109	Liver Neoplasms, Experimental	6.7%
110	Alcohol-Induced Disorders	6.7%
111	Asthma, Aspirin-Induced	6.7%
112	Reye Syndrome	6.6%
113	Pancreatitis, Alcoholic	6.6%
114	Lead Poisoning, Nervous System, Childhood	6.6%
115	Lead Poisoning, Nervous System, Adult	6.6%
116	Acute Generalized Exanthematous Pustulosis	6.6%
117	Massive Hepatic Necrosis	6.2%
118	Autoimmune hepatitis	6%
119	Peritoneal Neoplasms	5.8%
120	Bile Duct Neoplasms	5.7%
121	gallbladder neoplasm	5.7%
122	Intestinal Neoplasms	5.7%
123	Stomach Neoplasms	5.7%
124	Mesenteric vascular insufficiency	5.7%
125	Erythema Nodosum	5.6%
126	Serum Sickness	5.6%
127	Variegate Porphyria	5.6%
128	Acute intermittent porphyria	5.6%
129	Porphyria Cutanea Tarda	5.6%
130	Esophageal Atresia	5.6%
131	Intestinal Atresia	5.6%
132	Mesenteric Vascular Occlusion	5.6%
133	Intestinal Fistula	5.6%
134	Enterocutaneous Fistula	5.6%
135	Acrodynia	5.5%
136	Proctocolitis	5.5%
137	Colorectal Neoplasms	5.4%
138	Alcohol Use Disorder	5.3%
139	Alcoholic Intoxication	5.3%
140	Dysentery	5.3%
141	Enteritis	5.3%
142	Enterocolitis	5.3%
143	Esophagitis	5.3%
144	Gastritis	5.3%
145	Heroin Dependence	5.3%
146	Inflammatory Bowel Diseases	5.3%
147	Morphine Dependence	5.3%
148	Alcohol abuse	5.3%
149	Cholecystolithiasis	5.3%
150	Hepatitis, Viral, Animal	5.2%
151	Pancreatic Neoplasm	5.1%
152	Bile Duct Diseases	5.1%
153	Cholelithiasis	5.1%
154	Chylous Ascites	5.1%
155	Esophageal Diseases	5.1%
156	Gastroenteritis	5.1%
157	Intestinal Diseases	5.1%
158	Pancreatic Insufficiency	5.1%
159	Pancreatitis	5.1%
160	Pneumoperitoneum	5.1%
161	Stomach Diseases	5.1%
162	Hepatitis E	5.1%
163	Hepatitis B	5%
164	Hepatitis C	5%
165	Hepatitis A	5%
166	Esophageal Neoplasms	5%
167	Hepatic Encephalopathy	4.9%
168	Duodenitis	4.9%
169	Ileitis	4.9%
170	Erosive Duodenitis	4.9%
171	Cecal Neoplasms	4.9%
172	Duodenal Neoplasms	4.9%
173	Choledochal Cyst	4.9%
174	Rectal Fistula	4.7%
175	Anal Fistula	4.7%
176	Colitis	4.6%
177	Duodenogastric Reflux	4.6%
178	Peptic Ulcer	4.6%
179	Proctitis	4.6%
180	Choledocholithiasis	4.6%
181	Zellweger Syndrome	4.6%
182	Chemical and Drug Induced Liver Injury, Chronic	4.4%
183	Gastrointestinal Stromal Tumors	4.4%
184	Binge Drinking	4.4%
185	Toxic Epidermal Necrolysis	4.4%
186	Stevens-Johnson Syndrome	4.4%
187	Hepatolenticular Degeneration	4.2%
188	Pancreatic Cyst	4.1%
189	Anus Neoplasms	4.1%
190	Sigmoid Neoplasms	4.1%
191	Pouchitis	4.1%
192	Anus, Imperforate	4.1%
193	Gastrointestinal Hemorrhage	4.1%
194	Hemoperitoneum	4.1%
195	Mesenteric Panniculitis	4.1%
196	Panniculitis, Peritoneal	4.1%
197	Peritonitis	4.1%
198	Peritoneal Fibrosis	4.1%
199	Encapsulating Peritoneal Sclerosis	4.1%
200	Anorectal Malformations	4.1%
201	Appendiceal Neoplasms	4%
202	Colonic Neoplasms	4%
203	Rectal Neoplasms	4%
204	Biliary Fistula	4%
205	Gastric Fistula	4%
206	Tuberculosis, Gastrointestinal	4%
207	Cardiomyopathy, Alcoholic	4%
208	Crohn Disease	3.9%
209	Duodenal Obstruction	3.9%
210	Enterocolitis, Neutropenic	3.9%
211	Necrotizing Enterocolitis	3.9%
212	Appendicitis	3.9%
213	Duodenal Ulcer	3.6%
214	Peptic Ulcer Perforation	3.6%
215	Gastric ulcer	3.6%
216	Adenomatous Polyposis Coli	3.5%
217	Fetal Alcohol Spectrum Disorders	3.4%
218	Cecal Diseases	3.3%
219	Cholangitis	3.3%
220	Cholecystitis	3.3%
221	Cholestasis	3.3%
222	Colonic Diseases	3.3%
223	Common Bile Duct Diseases	3.3%
224	Esophageal Stenosis	3.3%
225	Ileal Diseases	3.3%
226	Intestinal Obstruction	3.3%
227	Intestinal Perforation	3.3%
228	Jejunal Diseases	3.3%
229	Pneumatosis Cystoides Intestinalis	3.3%
230	Rectal Diseases	3.3%
231	Gastric Dilatation	3.3%
232	Pancreatitis, Chronic	3.3%
233	Gastric outlet obstruction	3.3%
234	Cronkhite-Canada Syndrome	3.3%
235	Intestinal Polyposis	3.3%
236	Wernicke Encephalopathy	3.3%
237	Enterocolitis, Pseudomembranous	3.3%
238	pseudomembranous colitis	3.3%
239	Dysentery, Bacillary	3.3%
240	Colonic Pseudo-Obstruction	3.1%
241	Colitis, Ischemic	3%
242	Cystic Fibrosis	3%
243	Congenital Hyperinsulinism	2.9%
244	Rift Valley Fever	2.8%
245	Esophageal Perforation	2.8%
246	Intestinal Diseases, Parasitic	2.8%
247	Barrett Esophagus	2.7%
248	Deglutition Disorders	2.7%
249	Achlorhydria	2.7%
250	Pancreatic Pseudocyst	2.7%
251	Gastric Antral Vascular Ectasia	2.7%
252	Peptic Ulcer Hemorrhage	2.6%
253	Gastroparesis	2.6%
254	Carcinoma, Pancreatic Ductal	2.6%
255	Cholestasis, Extrahepatic	2.5%
256	Biliary Dyskinesia	2.5%
257	Cholangitis, Sclerosing	2.5%
258	Colonic Diseases, Functional	2.5%
259	Esophageal motility disorders	2.5%
260	Fecal Incontinence	2.5%
261	Fecal Impaction	2.5%
262	Intussusception	2.5%
263	Mallory-Weiss Syndrome	2.5%
264	Megacolon	2.5%
265	Pyloric Stenosis	2.5%
266	Acalculous Cholecystitis	2.5%
267	Ileus	2.5%
268	Meconium ileus	2.5%
269	Melena	2.2%
270	Hematemesis	2.2%
271	insulinoma	2.2%
272	Gastrinoma	2.2%
273	Glucagonoma	2.2%
274	Esophageal Achalasia	2.1%
275	Anal Fissure	2.1%
276	Intestinal Pseudo-Obstruction	2.1%
277	Irritable Bowel Syndrome	2.1%
278	Superior Mesenteric Artery Syndrome	2.1%
279	Emphysematous Cholecystitis	2.1%
280	Neurogenic Bowel	2.1%
281	Sphincter of Oddi Dysfunction	2.1%
282	Anal Ulcer	2.1%
283	Hemorrhoids	2%
284	Afferent Loop Syndrome	2%
285	Celiac Disease	2%
286	Short Bowel Syndrome	2%
287	Sprue, Tropical	2%
288	Steatorrhea	2%
289	Rectocele	2%
290	Sprue	2%
291	Diverticulitis	2%
292	Dumping Syndrome	2%
293	Rectal Prolapse	2%
294	Vipoma	1.9%
295	Nesidioblastosis	1.9%
296	Giardiasis	1.7%
297	Diverticulum	1.7%
298	Diverticulosis	1.7%
299	Pruritus Ani	1.7%
300	Laryngopharyngeal Reflux	1.5%
301	Peutz-Jeghers Syndrome	1.4%
302	Lactose Intolerance	1.4%
303	Cryptosporidiosis	1.1%
304	CREST Syndrome	0.9%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234