MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Esophageal Perforation

(UMLS:C0014860)

Definition:: An opening or hole in the ESOPHAGUS that is caused by TRAUMA, injury, or pathological process.
UMLS ID:: C0014860
MeSH ID:: D004939

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.468

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.348

Synonym(s)

Esophageal Perforation

ESOPHAGEAL PERFORATION

ESOPHAGUS PERFORATION

Esophageal perforation

Esophagus, Perforation Of

OESOPHAGEAL PERFORATION

Oesophageal perforation

Perforation Of Esophagus

Perforation of Esophagus

10.

Perforation of esophagus

11.

Perforation of oesophagus

12.

esophageal perforation

Associated Drug(s)

	Name	Data Source
1	Amoxapine	OFFSIDES
2	Atomoxetine Hydrochloride	OFFSIDES
3	Calcium Citrate	OFFSIDES
4	Clozapine	OFFSIDES
5	Daunorubicin	OFFSIDES
6	Dihematoporphyrin Ether	OFFSIDES
7	Docetaxel	OFFSIDES
8	Etoposide	OFFSIDES
9	Fluorouracil	OFFSIDES
10	Ibandronic Acid	OFFSIDES
11	Lamotrigine	OFFSIDES
12	Leucovorin	OFFSIDES
13	Nicotine	OFFSIDES
14	Olopatadine Hydrochloride	OFFSIDES
15	Paclitaxel	OFFSIDES
16	Panipenem-betamipron	OFFSIDES
17	Pantoprazole	OFFSIDES
18	Pyridostigmine Bromide	OFFSIDES
19	Sodium Bicarbonate	OFFSIDES
20	Sunitinib	OFFSIDES
21	Tiapride Hydrochloride	OFFSIDES
22	Vancomycin	OFFSIDES
23	Zoledronic Acid	OFFSIDES
24	bicalutamide	OFFSIDES
25	cyclobenzaprine	OFFSIDES
26	nedaplatin	OFFSIDES
27	sennoside A&B	OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Esophagitis	35.1%
2	Esophageal Stenosis	33.3%
3	Esophageal and Gastric Varices	28.1%
4	Frostbite	26.4%
5	Barrett Esophagus	25%
6	Deglutition Disorders	25%
7	Esophageal motility disorders	24.7%
8	Esophageal Atresia	23.9%
9	Hip Fractures	22.5%
10	Gastroenteritis	22%
11	Intestinal Diseases	22%
12	Stomach Diseases	22%
13	Crush syndrome	21.8%
14	Femoral Fractures	21.8%
15	Tibial Fractures	21.8%
16	Esophageal Neoplasms	21.5%
17	Zollinger-Ellison syndrome	21.2%
18	Dysentery	21.1%
19	Enteritis	21.1%
20	Enterocolitis	21.1%
21	Gastritis	21.1%
22	Inflammatory Bowel Diseases	21.1%
23	Athletic Injuries	20.5%
24	Hand Injuries	20.5%
25	Soft Tissue Injuries	20.5%
26	Sprain	20.5%
27	Sprains and Strains	20.5%
28	Tendon Injuries	20.5%
29	Laceration	20.5%
30	Wounds, Penetrating	20.5%
31	Heat Cramps	20.5%
32	Rupture	20.5%
33	Esophageal Achalasia	20.5%
34	Chilblains	19.6%
35	Spinal Fractures	19.6%
36	Proctocolitis	19.2%
37	Duodenitis	18.4%
38	Ileitis	18.4%
39	Erosive Duodenitis	18.4%
40	Colitis	18.3%
41	Duodenogastric Reflux	18.3%
42	Peptic Ulcer	18.3%
43	Proctitis	18.3%
44	Iliotibial Band Syndrome	17.5%
45	Gastrointestinal Neoplasms	17.1%
46	Hip Dislocation	17.1%
47	Shoulder Dislocation	17.1%
48	Splenic Rupture	17.1%
49	Hip Dysplasia	17.1%
50	Colorectal Neoplasms	16.2%
51	Gastrointestinal Hemorrhage	16.1%
52	Intestinal Neoplasms	16%
53	Stomach Neoplasms	16%
54	Tuberculosis, Gastrointestinal	15.8%
55	Trauma, Nervous System	15.7%
56	Crohn Disease	15.5%
57	Duodenal Obstruction	15.5%
58	Enterocolitis, Neutropenic	15.5%
59	Necrotizing Enterocolitis	15.5%
60	Pouchitis	15.2%
61	Bites and Stings	15.1%
62	Extravasation of Diagnostic and Therapeutic Materials	15.1%
63	Vascular System Injuries	15.1%
64	Tympanic Membrane Perforation	15.1%
65	Tooth Injuries	15.1%
66	Asphyxia	14.8%
67	Shock, Traumatic	14.8%
68	Self Mutilation	14.7%
69	Human Bite	14.6%
70	Contusions	14.6%
71	Decompression Sickness	14.6%
72	Finger Injuries	14.6%
73	Flail Chest	14.6%
74	Fractures, Closed	14.6%
75	Pathological fracture	14.6%
76	Heart Injuries	14.6%
77	Heat Exhaustion	14.6%
78	Heat Stroke	14.6%
79	Knee Injuries	14.6%
80	Foot Injuries	14.6%
81	Decapitation	14.6%
82	Ankle Fracture	14.6%
83	Avulsion fracture	14.6%
84	Compression fracture	14.6%
85	Osteoporotic Fractures	14.6%
86	Appendicitis	14.5%
87	Cecal Neoplasms	14.3%
88	Duodenal Neoplasms	14.3%
89	Cecal Diseases	14.3%
90	Colonic Diseases	14.3%
91	Ileal Diseases	14.3%
92	Intestinal Obstruction	14.3%
93	Intestinal Perforation	14.3%
94	Jejunal Diseases	14.3%
95	Pneumatosis Cystoides Intestinalis	14.3%
96	Rectal Diseases	14.3%
97	Gastric Dilatation	14.3%
98	Gastric outlet obstruction	14.3%
99	Cronkhite-Canada Syndrome	14.3%
100	Intestinal Polyposis	14.3%
101	Duodenal Ulcer	14.2%
102	Peptic Ulcer Perforation	14.2%
103	Gastric ulcer	14.2%
104	Eye Burns	14.1%
105	Laryngopharyngeal Reflux	13.8%
106	Splenosis	13.8%
107	Mesenteric vascular insufficiency	12.9%
108	Biliary Tract Diseases	12.8%
109	Liver diseases	12.8%
110	Pancreatic Diseases	12.8%
111	Intestinal Atresia	12.7%
112	Mesenteric Vascular Occlusion	12.7%
113	Intestinal Fistula	12.6%
114	Enterocutaneous Fistula	12.6%
115	Rectal Fistula	12.4%
116	Anal Fistula	12.4%
117	Anus Neoplasms	12.3%
118	Sigmoid Neoplasms	12.3%
119	Enterocolitis, Pseudomembranous	12.2%
120	pseudomembranous colitis	12.2%
121	Dysentery, Bacillary	12.2%
122	Colonic Pseudo-Obstruction	12.2%
123	Pseudarthrosis	11.9%
124	Smoke Inhalation Injury	11.9%
125	Appendiceal Neoplasms	11.8%
126	Colonic Neoplasms	11.8%
127	Rectal Neoplasms	11.8%
128	Spinal Cord Injuries	11.8%
129	Drowning	11.6%
130	Brain Concussion	11.4%
131	Colitis, Ischemic	11.4%
132	Intestinal Diseases, Parasitic	11.1%
133	Gastrointestinal Stromal Tumors	11%
134	Craniocerebral Trauma	10.9%
135	Tendinitis	10.9%
136	Lung Injury	10.9%
137	Tendinopathy	10.9%
138	Foreign-Body Reaction	10.7%
139	Insect Bites and Stings	10.7%
140	Paralysis, Obstetric	10.7%
141	Sunburn	10.7%
142	Tooth Avulsion	10.7%
143	Conus Medullaris Syndrome	10.7%
144	Near Drowning	10.6%
145	Osteoradionecrosis	10.6%
146	Colonic Diseases, Functional	10.6%
147	Fecal Incontinence	10.6%
148	Fecal Impaction	10.6%
149	Intussusception	10.6%
150	Megacolon	10.6%
151	Pyloric Stenosis	10.6%
152	Ileus	10.6%
153	Meconium ileus	10.6%
154	Achlorhydria	10.5%
155	Gastric Antral Vascular Ectasia	10.5%
156	Peptic Ulcer Hemorrhage	10.4%
157	Gastroparesis	10.4%
158	Brain Contusion	10.4%
159	Adenomatous Polyposis Coli	10.2%
160	Digestive System Neoplasms	9.4%
161	Radiation injury	9.4%
162	Facial Injuries	8.8%
163	Anal Fissure	8.8%
164	Granuloma, Foreign-Body	8.8%
165	Intestinal Pseudo-Obstruction	8.8%
166	Irritable Bowel Syndrome	8.8%
167	Superior Mesenteric Artery Syndrome	8.8%
168	Enthesopathy	8.8%
169	Neurogenic Bowel	8.8%
170	Anal Ulcer	8.8%
171	Neoplasms, Radiation-Induced	8.8%
172	Uterine Perforation	8.7%
173	Liver neoplasms	8.6%
174	Peripheral Nerve Injuries	8.6%
175	Medial Tibial Stress Syndrome	8.6%
176	Pancreatic Fistula	8.5%
177	Melena	8.4%
178	Uterine Rupture	8.4%
179	Central Cord Syndrome	8.4%
180	Hematemesis	8.2%
181	Hemorrhoids	8%
182	Afferent Loop Syndrome	7.8%
183	Celiac Disease	7.8%
184	Short Bowel Syndrome	7.8%
185	Sprue, Tropical	7.8%
186	Steatorrhea	7.8%
187	Rectocele	7.8%
188	Sprue	7.8%
189	Diverticulitis	7.8%
190	Dumping Syndrome	7.8%
191	Rectal Prolapse	7.8%
192	Bile Duct Diseases	7.3%
193	Cholelithiasis	7.3%
194	Chylous Ascites	7.3%
195	Fatty Liver	7.3%
196	Hepatitis	7.3%
197	Portal Hypertension	7.3%
198	Liver Cirrhosis	7.3%
199	Pancreatic Insufficiency	7.3%
200	Pancreatitis	7.3%
201	Pneumoperitoneum	7.3%
202	Focal Nodular Hyperplasia	7.3%
203	Hepatic Insufficiency	7.3%
204	Steatohepatitis	7.3%
205	CREST Syndrome	7.3%
206	Biliary cirrhosis	7.2%
207	Cardiotoxicity	7.1%
208	Peritoneal Neoplasms	7.1%
209	Leukemia, Radiation-Induced	7%
210	Cholecystolithiasis	7%
211	Brain Injuries	6.9%
212	Radiation Pneumonitis	6.9%
213	Radiation Fibrosis	6.9%
214	Coma, Post-Head Injury	6.9%
215	Aortic Rupture	6.9%
216	Bile Duct Neoplasms	6.9%
217	gallbladder neoplasm	6.9%
218	Carpal Tunnel Syndrome	6.8%
219	Brain Hemorrhage, Traumatic	6.6%
220	Pruritus Ani	6.5%
221	Eye Injuries	6.4%
222	Giardiasis	6.4%
223	Diverticulum	6.2%
224	Diverticulosis	6.2%
225	Brain Injuries, Diffuse	6.1%
226	Traumatic Brain Injury	6.1%
227	Choledocholithiasis	6.1%
228	Cubital Tunnel Syndrome	6.1%
229	Pancreatic Neoplasm	6.1%
230	Choledochal Cyst	5.9%
231	Abnormalities, Radiation-Induced	5.9%
232	Radiation Injuries, Experimental	5.8%
233	Diffuse Axonal Injury	5.7%
234	Liver Diseases, Parasitic	5.7%
235	Fatty Liver, Alcoholic	5.5%
236	Hepatitis, Alcoholic	5.5%
237	Liver Cirrhosis, Alcoholic	5.5%
238	Hepatic Veno-Occlusive Disease	5.5%
239	Pancreatic Cyst	5.5%
240	Peliosis Hepatis	5.5%
241	Hepatopulmonary Syndrome	5.5%
242	Anus, Imperforate	5.4%
243	Hemoperitoneum	5.4%
244	Hepatomegaly	5.4%
245	Mesenteric Panniculitis	5.4%
246	Panniculitis, Peritoneal	5.4%
247	Peritonitis	5.4%
248	Peritoneal Fibrosis	5.4%
249	Encapsulating Peritoneal Sclerosis	5.4%
250	Anorectal Malformations	5.4%
251	Biliary Fistula	5.3%
252	Gastric Fistula	5.3%
253	Hepatic Vein Thrombosis	5.3%
254	Liver Abscess	5.3%
255	Budd-Chiari Syndrome	5.3%
256	Peutz-Jeghers Syndrome	5.2%
257	Pneumocephalus	5.1%
258	Olfactory Nerve Injuries	5.1%
259	Cerebrospinal Fluid Otorrhea	5.1%
260	Cerebrospinal Fluid Rhinorrhea	5.1%
261	Lactose Intolerance	5.1%
262	Epilepsy, Post-Traumatic	5.1%
263	Corneal Scar	4.9%
264	Vertebral Artery Dissection	4.8%
265	Cholangitis	4.8%
266	Cholecystitis	4.8%
267	Cholestasis	4.8%
268	Common Bile Duct Diseases	4.8%
269	Hepatitis, Chronic	4.8%
270	Liver Failure	4.8%
271	Pancreatitis, Chronic	4.8%
272	Non-alcoholic Fatty Liver Disease	4.8%
273	Chronic active hepatitis	4.8%
274	Corneal Perforation	4.6%
275	Hepatocellular Adenoma	4.5%
276	Facial Nerve Injuries	4.4%
277	Chemical and Drug Induced Liver Injury	4.3%
278	Hepatorenal Syndrome	4.2%
279	Carotid Artery Injuries	4.2%
280	Liver Abscess, Amebic	3.9%
281	Liver Neoplasms, Experimental	3.9%
282	Cryptosporidiosis	3.9%
283	Hematoma, Subdural	3.7%
284	Hematoma, Epidural, Cranial	3.7%
285	Hepatitis, Animal	3.7%
286	Hepatitis, Viral, Human	3.7%
287	Cystic Fibrosis	3.6%
288	Cholestasis, Extrahepatic	3.5%
289	Biliary Dyskinesia	3.5%
290	Cholangitis, Sclerosing	3.5%
291	Liver Failure, Acute	3.5%
292	Acalculous Cholecystitis	3.5%
293	End Stage Liver Disease	3.5%
294	Liver Cirrhosis, Experimental	3.5%
295	Pancreatic Pseudocyst	3.5%
296	Hematoma, Subdural, Intracranial	3.5%
297	Hematoma, Subdural, Chronic	3.5%
298	Hematoma, Subdural, Acute	3.5%
299	Porphyrias, Hepatic	3.5%
300	Congenital Hyperinsulinism	3.5%
301	Pancreatitis, Alcoholic	3.5%
302	Subarachnoid Hemorrhage, Traumatic	3.3%
303	Carotid Artery, Internal, Dissection	3.3%
304	Hepatitis B, Chronic	3.1%
305	Hepatitis C, Chronic	3.1%
306	Carcinoma, Pancreatic Ductal	3%
307	Massive Hepatic Necrosis	2.9%
308	Emphysematous Cholecystitis	2.9%
309	Sphincter of Oddi Dysfunction	2.9%
310	Fascioliasis	2.8%
311	Echinococcosis, Hepatic	2.8%
312	Chemical and Drug Induced Liver Injury, Chronic	2.8%
313	Reye Syndrome	2.8%
314	Autoimmune hepatitis	2.7%
315	insulinoma	2.5%
316	Gastrinoma	2.5%
317	Glucagonoma	2.5%
318	Nesidioblastosis	2.3%
319	Variegate Porphyria	2.3%
320	Acute intermittent porphyria	2.3%
321	Porphyria Cutanea Tarda	2.3%
322	Vipoma	2.2%
323	Hepatitis, Viral, Animal	2.2%
324	Hepatitis E	2.1%
325	Hepatitis B	2.1%
326	Hepatitis C	2.1%
327	Hepatitis A	2.1%
328	Hepatic Encephalopathy	2.1%
329	Zellweger Syndrome	1.7%
330	Hepatolenticular Degeneration	1.5%
331	Rift Valley Fever	1.1%

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