MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Esophageal Achalasia

(UMLS:C0014848)

Definition:: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).
UMLS ID:: C0014848
MeSH ID:: D004931

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.119.500.432

Synonym(s)

Esophageal Achalasia

ACHALASIA CARDIAE

Achalasia

Achalasia and cardiospasm

Achalasia of cardia

Achalasia of esophagus

Achalasia of oesophagus

Achalasia of the esophagus

Achalasia;oesophageal

10.

CARDIOSPASM

11.

Cardiospasm

12.

Cardiospasm, NOS

13.

Esophageal achalasia

14.

Hypertensive lower esophageal sphincter

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Diethylnitrosamine		16302075	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Esophageal Stenosis	28.5%
2	Esophagitis	27.3%
3	Laryngopharyngeal Reflux	25.5%
4	Gastroenteritis	22.7%
5	Intestinal Diseases	22.7%
6	Stomach Diseases	22.7%
7	Esophageal and Gastric Varices	21.9%
8	Esophageal Perforation	20.5%
9	Barrett Esophagus	19.6%
10	Esophageal Atresia	18.4%
11	Mallory-Weiss Syndrome	16.8%
12	Dysentery	16.4%
13	Enteritis	16.4%
14	Enterocolitis	16.4%
15	Gastritis	16.4%
16	Inflammatory Bowel Diseases	16.4%
17	Gastrointestinal Neoplasms	15.3%
18	Biliary Tract Diseases	15.3%
19	Liver diseases	15.3%
20	Pancreatic Diseases	15.3%
21	Gastrointestinal Hemorrhage	15.1%
22	Esophageal Neoplasms	15.1%
23	Tuberculosis, Gastrointestinal	14.8%
24	CREST Syndrome	14.3%
25	Zollinger-Ellison syndrome	13.3%
26	Colitis	13%
27	Duodenogastric Reflux	13%
28	Peptic Ulcer	13%
29	Proctitis	13%
30	Cecal Diseases	12.2%
31	Colonic Diseases	12.2%
32	Ileal Diseases	12.2%
33	Intestinal Obstruction	12.2%
34	Intestinal Perforation	12.2%
35	Jejunal Diseases	12.2%
36	Pneumatosis Cystoides Intestinalis	12.2%
37	Rectal Diseases	12.2%
38	Gastric Dilatation	12.2%
39	Gastric outlet obstruction	12.2%
40	Cronkhite-Canada Syndrome	12.2%
41	Intestinal Polyposis	12.2%
42	Intestinal Neoplasms	11.5%
43	Stomach Neoplasms	11.5%
44	Duodenitis	10.8%
45	Ileitis	10.8%
46	Erosive Duodenitis	10.8%
47	Mesenteric vascular insufficiency	10.2%
48	Digestive System Neoplasms	10.2%
49	Intestinal Atresia	10%
50	Mesenteric Vascular Occlusion	10%
51	Intestinal Fistula	10%
52	Enterocutaneous Fistula	10%
53	Appendicitis	9.8%
54	Crohn Disease	9.6%
55	Duodenal Obstruction	9.6%
56	Enterocolitis, Neutropenic	9.6%
57	Necrotizing Enterocolitis	9.6%
58	Proctocolitis	9.6%
59	Colorectal Neoplasms	8.9%
60	Intestinal Diseases, Parasitic	8.8%
61	Achlorhydria	8.2%
62	Gastric Antral Vascular Ectasia	8.2%
63	Gastrointestinal Stromal Tumors	8.2%
64	Peptic Ulcer Hemorrhage	8.1%
65	Gastroparesis	8.1%
66	Cecal Neoplasms	8%
67	Duodenal Neoplasms	8%
68	Duodenal Ulcer	8%
69	Peptic Ulcer Perforation	8%
70	Gastric ulcer	8%
71	Liver neoplasms	7.7%
72	Pancreatic Fistula	7.6%
73	Bile Duct Diseases	7.6%
74	Cholelithiasis	7.6%
75	Chylous Ascites	7.6%
76	Fatty Liver	7.6%
77	Hepatitis	7.6%
78	Portal Hypertension	7.6%
79	Liver Cirrhosis	7.6%
80	Pancreatic Insufficiency	7.6%
81	Pancreatitis	7.6%
82	Pneumoperitoneum	7.6%
83	Focal Nodular Hyperplasia	7.6%
84	Hepatic Insufficiency	7.6%
85	Steatohepatitis	7.6%
86	Rectal Fistula	7.4%
87	Anal Fistula	7.4%
88	Enterocolitis, Pseudomembranous	7.2%
89	pseudomembranous colitis	7.2%
90	Dysentery, Bacillary	7.2%
91	Colonic Diseases, Functional	7.2%
92	Fecal Incontinence	7.2%
93	Fecal Impaction	7.2%
94	Intussusception	7.2%
95	Megacolon	7.2%
96	Pyloric Stenosis	7.2%
97	Ileus	7.2%
98	Meconium ileus	7.2%
99	Pouchitis	7.1%
100	Melena	6.2%
101	Colitis, Ischemic	6.1%
102	Peritoneal Neoplasms	6.1%
103	Hematemesis	6.1%
104	Colonic Pseudo-Obstruction	5.5%
105	Cholecystolithiasis	5.5%
106	Liver Diseases, Parasitic	5.4%
107	Appendiceal Neoplasms	5.3%
108	Colonic Neoplasms	5.3%
109	Rectal Neoplasms	5.3%
110	Hepatic Veno-Occlusive Disease	5.1%
111	Pancreatic Cyst	5.1%
112	Peliosis Hepatis	5.1%
113	Hepatopulmonary Syndrome	5.1%
114	Pancreatic Neoplasm	5.1%
115	Anus, Imperforate	5%
116	Hemoperitoneum	5%
117	Hepatomegaly	5%
118	Mesenteric Panniculitis	5%
119	Panniculitis, Peritoneal	5%
120	Peritonitis	5%
121	Peritoneal Fibrosis	5%
122	Encapsulating Peritoneal Sclerosis	5%
123	Anorectal Malformations	5%
124	Biliary Fistula	5%
125	Gastric Fistula	5%
126	Hemorrhoids	5%
127	Hepatic Vein Thrombosis	4.9%
128	Liver Abscess	4.9%
129	Budd-Chiari Syndrome	4.9%
130	Bile Duct Neoplasms	4.9%
131	gallbladder neoplasm	4.9%
132	Biliary cirrhosis	4.9%
133	Afferent Loop Syndrome	4.9%
134	Celiac Disease	4.9%
135	Short Bowel Syndrome	4.9%
136	Sprue, Tropical	4.9%
137	Steatorrhea	4.9%
138	Rectocele	4.9%
139	Sprue	4.9%
140	Diverticulitis	4.8%
141	Dumping Syndrome	4.8%
142	Rectal Prolapse	4.8%
143	Anal Fissure	4.8%
144	Intestinal Pseudo-Obstruction	4.8%
145	Irritable Bowel Syndrome	4.8%
146	Superior Mesenteric Artery Syndrome	4.8%
147	Neurogenic Bowel	4.8%
148	Anal Ulcer	4.8%
149	Choledochal Cyst	4.7%
150	Anus Neoplasms	4.7%
151	Sigmoid Neoplasms	4.7%
152	Adenomatous Polyposis Coli	4.7%
153	Choledocholithiasis	4.3%
154	Cholangitis	4.1%
155	Cholecystitis	4.1%
156	Cholestasis	4.1%
157	Common Bile Duct Diseases	4.1%
158	Fatty Liver, Alcoholic	4.1%
159	Hepatitis, Alcoholic	4.1%
160	Hepatitis, Chronic	4.1%
161	Liver Cirrhosis, Alcoholic	4.1%
162	Liver Failure	4.1%
163	Pancreatitis, Chronic	4.1%
164	Non-alcoholic Fatty Liver Disease	4.1%
165	Chronic active hepatitis	4.1%
166	Chemical and Drug Induced Liver Injury	3.9%
167	Giardiasis	3.8%
168	Hepatorenal Syndrome	3.7%
169	Diverticulum	3.7%
170	Diverticulosis	3.7%
171	Hepatocellular Adenoma	3.3%
172	Pruritus Ani	3.2%
173	Cystic Fibrosis	3.1%
174	Porphyrias, Hepatic	3%
175	Congenital Hyperinsulinism	3%
176	Peutz-Jeghers Syndrome	3%
177	Hepatitis, Animal	2.9%
178	Hepatitis, Viral, Human	2.9%
179	Lactose Intolerance	2.9%
180	Liver Abscess, Amebic	2.8%
181	Liver Neoplasms, Experimental	2.8%
182	Liver Cirrhosis, Experimental	2.7%
183	Pancreatic Pseudocyst	2.7%
184	Pancreatitis, Alcoholic	2.7%
185	Cholestasis, Extrahepatic	2.4%
186	Biliary Dyskinesia	2.4%
187	Cholangitis, Sclerosing	2.4%
188	Liver Failure, Acute	2.4%
189	Acalculous Cholecystitis	2.4%
190	End Stage Liver Disease	2.4%
191	Cryptosporidiosis	2.1%
192	Fascioliasis	2.1%
193	Echinococcosis, Hepatic	2.1%
194	Chemical and Drug Induced Liver Injury, Chronic	2.1%
195	Reye Syndrome	2%
196	Carcinoma, Pancreatic Ductal	2%
197	Autoimmune hepatitis	1.7%
198	Nesidioblastosis	1.6%
199	Variegate Porphyria	1.6%
200	Acute intermittent porphyria	1.6%
201	Porphyria Cutanea Tarda	1.6%
202	Hepatitis B, Chronic	1.6%
203	Hepatitis C, Chronic	1.6%
204	Massive Hepatic Necrosis	1.6%
205	Emphysematous Cholecystitis	1.6%
206	Sphincter of Oddi Dysfunction	1.6%
207	insulinoma	1.4%
208	Gastrinoma	1.4%
209	Glucagonoma	1.4%
210	Zellweger Syndrome	1.3%
211	Hepatitis, Viral, Animal	1.3%
212	Hepatitis E	1.3%
213	Hepatitis B	1.2%
214	Hepatitis C	1.2%
215	Hepatitis A	1.2%
216	Hepatolenticular Degeneration	1.2%
217	Hepatic Encephalopathy	1.2%
218	Vipoma	1.2%
219	Rift Valley Fever	0.5%

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