MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Esophageal motility disorders

(UMLS:C0014858)

Definition:: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
UMLS ID:: C0014858
MeSH ID:: D015154

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.119.500

Synonym(s)

Esophageal motility disorders

Dyskinesia oesophageal

Dyskinesia of esophagus

Dyskinesia of oesophagus

Dysmotility;oesophageal

ESOPHAGEAL DYSKINESIA

ESOPHAGEAL DYSMOTILITY

Esophageal dysmotility

Esophageal motility disorder

10.

Esophageal motor disorder

11.

Esophageal motor disorder, NOS

12.

Oesophageal dysmotility

13.

Oesophageal motility disorder

14.

Oesophageal motor disorder, NOS

15.

dyskinesia esophagus

16.

dyskinesia of esophagus

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Benztropine	8354511	CTD
2	Edrophonium	9051868	CTD
3	Nifedipine	2716305 3726585	CTD
4	Thiothixene	8354511	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Esophageal Stenosis	34.4%
2	Esophagitis	33%
3	Esophageal and Gastric Varices	26.4%
4	Gastroenteritis	25.4%
5	Intestinal Diseases	25.4%
6	Stomach Diseases	25.4%
7	Esophageal Perforation	24.7%
8	Barrett Esophagus	23.6%
9	Mallory-Weiss Syndrome	22.6%
10	Esophageal Atresia	21.8%
11	Dysentery	19.8%
12	Enteritis	19.8%
13	Enterocolitis	19.8%
14	Gastritis	19.8%
15	Inflammatory Bowel Diseases	19.8%
16	Esophageal Neoplasms	18.1%
17	Gastrointestinal Neoplasms	17.1%
18	Gastrointestinal Hemorrhage	16.9%
19	Zollinger-Ellison syndrome	16.6%
20	Tuberculosis, Gastrointestinal	16.5%
21	Biliary Tract Diseases	16.4%
22	Liver diseases	16.4%
23	Pancreatic Diseases	16.4%
24	Colitis	16.3%
25	Duodenogastric Reflux	16.3%
26	Peptic Ulcer	16.3%
27	Proctitis	16.3%
28	Cecal Diseases	14.8%
29	Colonic Diseases	14.8%
30	Ileal Diseases	14.8%
31	Intestinal Obstruction	14.8%
32	Intestinal Perforation	14.8%
33	Jejunal Diseases	14.8%
34	Pneumatosis Cystoides Intestinalis	14.8%
35	Rectal Diseases	14.8%
36	Gastric Dilatation	14.8%
37	Gastric outlet obstruction	14.8%
38	Cronkhite-Canada Syndrome	14.8%
39	Intestinal Polyposis	14.8%
40	Duodenitis	14.5%
41	Ileitis	14.5%
42	Erosive Duodenitis	14.5%
43	Intestinal Neoplasms	13.8%
44	Stomach Neoplasms	13.8%
45	Proctocolitis	13.6%
46	Crohn Disease	12.9%
47	Duodenal Obstruction	12.9%
48	Enterocolitis, Neutropenic	12.9%
49	Necrotizing Enterocolitis	12.9%
50	Appendicitis	12.3%
51	Mesenteric vascular insufficiency	12%
52	Colorectal Neoplasms	12%
53	Intestinal Atresia	11.8%
54	Mesenteric Vascular Occlusion	11.8%
55	Intestinal Fistula	11.7%
56	Enterocutaneous Fistula	11.7%
57	Duodenal Ulcer	11.2%
58	Peptic Ulcer Perforation	11.2%
59	Gastric ulcer	11.2%
60	Digestive System Neoplasms	10.8%
61	Pouchitis	10.8%
62	Cecal Neoplasms	10.7%
63	Duodenal Neoplasms	10.7%
64	Intestinal Diseases, Parasitic	10.6%
65	Achlorhydria	9.9%
66	Gastric Antral Vascular Ectasia	9.9%
67	Gastrointestinal Stromal Tumors	9.8%
68	Peptic Ulcer Hemorrhage	9.8%
69	Gastroparesis	9.8%
70	Rectal Fistula	9.7%
71	Anal Fistula	9.7%
72	Colonic Diseases, Functional	9.7%
73	Enterocolitis, Pseudomembranous	9.7%
74	Fecal Incontinence	9.7%
75	Fecal Impaction	9.7%
76	Intussusception	9.7%
77	Megacolon	9.7%
78	Pyloric Stenosis	9.7%
79	pseudomembranous colitis	9.7%
80	Ileus	9.7%
81	Dysentery, Bacillary	9.7%
82	Meconium ileus	9.7%
83	Colonic Pseudo-Obstruction	8.8%
84	Colitis, Ischemic	8.6%
85	Liver neoplasms	8.5%
86	Bile Duct Diseases	8.5%
87	Cholelithiasis	8.5%
88	Chylous Ascites	8.5%
89	Fatty Liver	8.5%
90	Hepatitis	8.5%
91	Portal Hypertension	8.5%
92	Liver Cirrhosis	8.5%
93	Pancreatic Fistula	8.5%
94	Pancreatic Insufficiency	8.5%
95	Pancreatitis	8.5%
96	Pneumoperitoneum	8.5%
97	Focal Nodular Hyperplasia	8.5%
98	Hepatic Insufficiency	8.5%
99	Steatohepatitis	8.5%
100	Appendiceal Neoplasms	7.9%
101	Colonic Neoplasms	7.9%
102	Rectal Neoplasms	7.9%
103	Anus Neoplasms	7.7%
104	Sigmoid Neoplasms	7.7%
105	Melena	7.5%
106	Hematemesis	7.3%
107	Anal Fissure	7.2%
108	Intestinal Pseudo-Obstruction	7.2%
109	Irritable Bowel Syndrome	7.2%
110	Superior Mesenteric Artery Syndrome	7.2%
111	Neurogenic Bowel	7.2%
112	Anal Ulcer	7.2%
113	Peritoneal Neoplasms	6.8%
114	Adenomatous Polyposis Coli	6.8%
115	Hemorrhoids	6.7%
116	Cholecystolithiasis	6.6%
117	Afferent Loop Syndrome	6.5%
118	Celiac Disease	6.5%
119	Short Bowel Syndrome	6.5%
120	Sprue, Tropical	6.5%
121	Steatorrhea	6.5%
122	Rectocele	6.5%
123	Sprue	6.5%
124	Diverticulitis	6.5%
125	Dumping Syndrome	6.5%
126	Rectal Prolapse	6.5%
127	Biliary cirrhosis	6.1%
128	Liver Diseases, Parasitic	6%
129	Bile Duct Neoplasms	5.9%
130	gallbladder neoplasm	5.9%
131	Hepatic Veno-Occlusive Disease	5.7%
132	Pancreatic Cyst	5.7%
133	Peliosis Hepatis	5.7%
134	Hepatopulmonary Syndrome	5.7%
135	Pancreatic Neoplasm	5.7%
136	Anus, Imperforate	5.6%
137	Hemoperitoneum	5.6%
138	Hepatomegaly	5.6%
139	Mesenteric Panniculitis	5.6%
140	Panniculitis, Peritoneal	5.6%
141	Peritonitis	5.6%
142	Peritoneal Fibrosis	5.6%
143	Encapsulating Peritoneal Sclerosis	5.6%
144	Anorectal Malformations	5.6%
145	Biliary Fistula	5.6%
146	Gastric Fistula	5.6%
147	Hepatic Vein Thrombosis	5.5%
148	Liver Abscess	5.5%
149	Budd-Chiari Syndrome	5.5%
150	Choledochal Cyst	5.4%
151	Choledocholithiasis	5.4%
152	Giardiasis	5.1%
153	Diverticulum	5%
154	Diverticulosis	5%
155	Cholangitis	4.9%
156	Cholecystitis	4.9%
157	Cholestasis	4.9%
158	Common Bile Duct Diseases	4.9%
159	Hepatitis, Chronic	4.9%
160	Liver Failure	4.9%
161	Pancreatitis, Chronic	4.9%
162	Non-alcoholic Fatty Liver Disease	4.9%
163	Chronic active hepatitis	4.9%
164	Fatty Liver, Alcoholic	4.9%
165	Hepatitis, Alcoholic	4.9%
166	Liver Cirrhosis, Alcoholic	4.9%
167	Pruritus Ani	4.9%
168	Chemical and Drug Induced Liver Injury	4.3%
169	Hepatorenal Syndrome	4.2%
170	Peutz-Jeghers Syndrome	4%
171	Hepatocellular Adenoma	3.9%
172	Lactose Intolerance	3.9%
173	Hepatitis, Animal	3.5%
174	Hepatitis, Viral, Human	3.5%
175	Cystic Fibrosis	3.5%
176	Porphyrias, Hepatic	3.4%
177	Congenital Hyperinsulinism	3.4%
178	Liver Abscess, Amebic	3.3%
179	Liver Neoplasms, Experimental	3.3%
180	Liver Cirrhosis, Experimental	3.3%
181	Pancreatic Pseudocyst	3.3%
182	Pancreatitis, Alcoholic	3.3%
183	Cholestasis, Extrahepatic	3.2%
184	Biliary Dyskinesia	3.2%
185	Cholangitis, Sclerosing	3.2%
186	Liver Failure, Acute	3.2%
187	Acalculous Cholecystitis	3.2%
188	End Stage Liver Disease	3.2%
189	Cryptosporidiosis	2.9%
190	Fascioliasis	2.5%
191	Echinococcosis, Hepatic	2.5%
192	Chemical and Drug Induced Liver Injury, Chronic	2.5%
193	Reye Syndrome	2.5%
194	Carcinoma, Pancreatic Ductal	2.4%
195	Massive Hepatic Necrosis	2.4%
196	Emphysematous Cholecystitis	2.4%
197	Sphincter of Oddi Dysfunction	2.4%
198	Hepatitis B, Chronic	2.3%
199	Hepatitis C, Chronic	2.3%
200	Autoimmune hepatitis	2.2%
201	Nesidioblastosis	1.9%
202	Variegate Porphyria	1.9%
203	Acute intermittent porphyria	1.9%
204	Porphyria Cutanea Tarda	1.9%
205	insulinoma	1.8%
206	Gastrinoma	1.8%
207	Glucagonoma	1.8%
208	Hepatitis, Viral, Animal	1.8%
209	Hepatitis E	1.7%
210	Hepatitis B	1.7%
211	Hepatitis C	1.7%
212	Hepatitis A	1.7%
213	Hepatic Encephalopathy	1.6%
214	Vipoma	1.6%
215	Zellweger Syndrome	1.5%
216	Hepatolenticular Degeneration	1.4%
217	Rift Valley Fever	0.7%

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