MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Liver Failure

(UMLS:C0085605)

Definition:: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
UMLS ID:: C0085605
MeSH ID:: D017093

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.308.500

Synonym(s)

Liver Failure

Failure;hepatic

HEPATIC FAILURE

Hepatic Failure

Hepatic failure

Hepatic failure, NOS

Hepatic failure, unspecified

Hepatic insufficiency

Hepatic insufficiency, NOS

10.

Liver decompensation

11.

Liver decompensation, NOS

12.

Liver failure

13.

Liver function failure

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetaminophen	View details 9196648 9285154 11316203 11375824 18004067 18377375 18645506 19835899	CTD
2	Acetylcysteine	11316203	CTD
3	Amiodarone	1689330	CTD
4	Amoxicillin-Potassium Clavulanate Combination	11422607 18028086	CTD
5	Amoxicillin	12439126	CTD
6	Aspirin	1972225	CTD
7	Azathioprine	3114679	CTD
8	Bilirubin	18618250	CTD
9	Bupropion	12549952	CTD
10	Carbamazepine	10331832 10369620	CTD
11	Carbimazole	8223196 12549952	CTD
12	Carbon Tetrachloride	11510480 15123358	CTD
13	Carboplatin	7630183	CTD
14	Cefdinir	18377375	CTD
15	Ciprofloxacin	7907714	CTD
16	Clarithromycin	8607519	CTD
17	Clenbuterol	15021963	CTD
18	Clindamycin	6295339	CTD
19	Cocaine	2758612 2772692	CTD
20	Cyclophosphamide	5454367	CTD
21	Cyproterone Acetate	8958378	CTD
22	Cytarabine	10327034 12531223	CTD
23	D-Galactosamine	11023982 11510480 27876602	CTD
24	Dacarbazine	528568 11901312	CTD
25	Dapsone	7973902 9451224	CTD
26	Daunorubicin	12531223	CTD
27	Didanosine	11556343 16288408	CTD
28	Disulfiram	2646364	CTD
29	Doxorubicin	8094161	CTD
30	Floxacillin	15773973	CTD
31	Floxuridine	2521475	CTD
32	Fluconazole	10631423	CTD
33	Flutamide	View details 2365984 9324896 10386060 14997310	CTD
34	Genistein	27876602	CTD
35	Gentamicins	6295339	CTD
36	Glyburide	1436270	CTD
37	Halothane	6392423	CTD
38	Ibuprofen	12358284	CTD
39	Imipramine	8741026	CTD
40	Isoniazid	View details 7924752 8178358 17667808 23764483	CTD
41	Ketoconazole	11308052	CTD
42	Lamivudine	9317091 16419112	CTD
43	Leflunomide	28988120	CTD
44	Lomustine	21418164	CTD
45	Mefloquine	9929030	CTD
46	Methimazole	20707932	CTD
47	Methotrexate	View details 2585411 8452577 8864370 16864853	CTD
48	Methylprednisolone	17154092	CTD
49	Minocycline	1532250 8470208 10685779	CTD
50	Nevirapine	10476768 14562855	CTD
51	Nitrofurantoin	View details 1588868 11908259 14983581 16968827	CTD
52	Nizatidine	7769203	CTD
53	Orlistat	11211898	CTD
54	Paroxetine	9190513	CTD
55	Pemoline	9562136	CTD
56	Phenytoin	2818777 10823022	CTD
57	Prednisolone	3781203 10566758	CTD
58	Prednisone	1669052	CTD
59	Prochlorperazine	14571732	CTD
60	Propofol	15153216	CTD
61	Propylthiouracil	View details 2343593 9025882 14530534 15251733	CTD
62	Quetiapine Fumarate	15618854	CTD
63	Ribavirin	16288408	CTD
64	Rifampin	76779 11316203 23764483	CTD
65	Ritonavir	19025478	CTD
66	Sevoflurane	11375824	CTD
67	Stavudine	9317091 18299183	CTD
68	Streptomycin	1534589	CTD
69	Sulfasalazine	13680174	CTD
70	Tamoxifen	9205462	CTD
71	Tetracycline	803665 4024961 19427351	CTD
72	Trimethoprim, Sulfamethoxazole Drug Combination	14712321 16807519	CTD
73	Troglitazone	9652998 10068399 10685643	CTD
74	Ursodeoxycholic Acid	22942741	CTD
75	Valproic Acid	View details 1606338 3112563 7925143 8157021 9090694 17168987 18716558 19239041	CTD
76	Vidarabine	3781203	CTD
77	Vinorelbine	12796036	CTD
78	Vitamin K	11316203	CTD
79	Zidovudine	9267960 11556343	CTD
80	adefovir dipivoxil	14647053 14997399 15104374	CTD
81	bicyclol	19427351	CTD
82	difebarbamate, febarbamate, phenobarbital drug combination	11007137	CTD
83	fanasil, pyrimethamine drug combination	2949680	CTD
84	fialuridine	10161259	CTD
85	gemcitabine	12796036	CTD
86	nefazodone	10068386 21823597	CTD
87	nimesulide	18049158	CTD
88	perhexiline maleate	6572824 7321956	CTD
89	tipranavir	19025478	CTD
90	usnic acid	21953288 22777745 23686521	CTD
91	valspodar	12531223	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Fatty Liver	31%
2	Hepatitis	31%
3	Portal Hypertension	31%
4	Liver Cirrhosis	31%
5	Focal Nodular Hyperplasia	31%
6	Steatohepatitis	31%
7	Liver Diseases, Parasitic	22%
8	Biliary cirrhosis	21.8%
9	Hepatic Veno-Occlusive Disease	20.9%
10	Peliosis Hepatis	20.9%
11	Hepatopulmonary Syndrome	20.9%
12	Liver neoplasms	20.7%
13	Hepatomegaly	20.5%
14	Hepatic Vein Thrombosis	20.1%
15	Liver Abscess	20.1%
16	Budd-Chiari Syndrome	20.1%
17	Hepatitis, Chronic	20%
18	Non-alcoholic Fatty Liver Disease	20%
19	Chronic active hepatitis	20%
20	Fatty Liver, Alcoholic	19.8%
21	Hepatitis, Alcoholic	19.8%
22	Liver Cirrhosis, Alcoholic	19.8%
23	Biliary Tract Diseases	18.5%
24	Gastrointestinal Diseases	18.5%
25	Pancreatic Diseases	18.5%
26	Esophageal and Gastric Varices	17.8%
27	Chemical and Drug Induced Liver Injury	15.8%
28	Hepatorenal Syndrome	15.1%
29	Hepatitis, Animal	14.3%
30	Hepatitis, Viral, Human	14.3%
31	Liver Abscess, Amebic	13.4%
32	Liver Cirrhosis, Experimental	13.3%
33	Digestive System Neoplasms	12.2%
34	Porphyrias, Hepatic	12.2%
35	Hepatitis B, Chronic	10.7%
36	Hepatitis C, Chronic	10.7%
37	Hepatocellular Adenoma	10.5%
38	Bile Duct Diseases	10.3%
39	Cholelithiasis	10.3%
40	Chylous Ascites	10.3%
41	Esophageal Diseases	10.3%
42	Gastroenteritis	10.3%
43	Gastrointestinal Neoplasms	10.3%
44	Intestinal Diseases	10.3%
45	Pancreatic Insufficiency	10.3%
46	Pancreatitis	10.3%
47	Pneumoperitoneum	10.3%
48	Stomach Diseases	10.3%
49	Pancreatic Fistula	10.3%
50	Fascioliasis	10.2%
51	Autoimmune hepatitis	10.1%
52	Echinococcosis, Hepatic	10.1%
53	Chemical and Drug Induced Liver Injury, Chronic	10%
54	Reye Syndrome	9.9%
55	Dysentery	8.9%
56	Enteritis	8.9%
57	Enterocolitis	8.9%
58	Esophagitis	8.9%
59	Gastritis	8.9%
60	Inflammatory Bowel Diseases	8.9%
61	Liver Neoplasms, Experimental	8.9%
62	Cholecystolithiasis	8.9%
63	Zollinger-Ellison syndrome	8.9%
64	Mesenteric vascular insufficiency	8.6%
65	Esophageal Atresia	8.5%
66	Intestinal Atresia	8.5%
67	Mesenteric Vascular Occlusion	8.5%
68	Intestinal Fistula	8.4%
69	Enterocutaneous Fistula	8.4%
70	Peritoneal Neoplasms	8.2%
71	Hepatitis, Viral, Animal	8%
72	Bile Duct Neoplasms	7.9%
73	gallbladder neoplasm	7.9%
74	Intestinal Neoplasms	7.9%
75	Stomach Neoplasms	7.9%
76	Variegate Porphyria	7.8%
77	Acute intermittent porphyria	7.8%
78	Porphyria Cutanea Tarda	7.8%
79	Colitis	7.7%
80	Duodenogastric Reflux	7.7%
81	Peptic Ulcer	7.7%
82	Proctitis	7.7%
83	Hepatitis E	7.7%
84	Choledocholithiasis	7.7%
85	Hepatitis B	7.6%
86	Hepatitis C	7.6%
87	Hepatitis A	7.5%
88	Duodenitis	7.3%
89	Ileitis	7.3%
90	Erosive Duodenitis	7.3%
91	Proctocolitis	7.2%
92	Pancreatic Cyst	7%
93	Colorectal Neoplasms	6.9%
94	Pancreatic Neoplasm	6.9%
95	Choledochal Cyst	6.8%
96	Anus, Imperforate	6.8%
97	Gastrointestinal Hemorrhage	6.8%
98	Hemoperitoneum	6.8%
99	Mesenteric Panniculitis	6.8%
100	Panniculitis, Peritoneal	6.8%
101	Peritonitis	6.8%
102	Peritoneal Fibrosis	6.8%
103	Encapsulating Peritoneal Sclerosis	6.8%
104	Anorectal Malformations	6.8%
105	Biliary Fistula	6.7%
106	Gastric Fistula	6.7%
107	Tuberculosis, Gastrointestinal	6.7%
108	Cecal Diseases	6.7%
109	Cholangitis	6.7%
110	Cholecystitis	6.7%
111	Cholestasis	6.7%
112	Colonic Diseases	6.7%
113	Common Bile Duct Diseases	6.7%
114	Esophageal Stenosis	6.7%
115	Ileal Diseases	6.7%
116	Intestinal Obstruction	6.7%
117	Intestinal Perforation	6.7%
118	Jejunal Diseases	6.7%
119	Pneumatosis Cystoides Intestinalis	6.7%
120	Rectal Diseases	6.7%
121	Gastric Dilatation	6.7%
122	Pancreatitis, Chronic	6.7%
123	Gastric outlet obstruction	6.7%
124	Cronkhite-Canada Syndrome	6.7%
125	Intestinal Polyposis	6.7%
126	Esophageal Neoplasms	6.6%
127	Gastrointestinal Stromal Tumors	6.6%
128	Crohn Disease	6.5%
129	Duodenal Obstruction	6.5%
130	Enterocolitis, Neutropenic	6.5%
131	Necrotizing Enterocolitis	6.5%
132	Rectal Fistula	6.5%
133	Anal Fistula	6.5%
134	Cecal Neoplasms	6.5%
135	Duodenal Neoplasms	6.5%
136	Pouchitis	6%
137	Duodenal Ulcer	5.9%
138	Peptic Ulcer Perforation	5.9%
139	Gastric ulcer	5.9%
140	Appendicitis	5.8%
141	Zellweger Syndrome	5.4%
142	Appendiceal Neoplasms	5.3%
143	Colonic Neoplasms	5.3%
144	Rectal Neoplasms	5.3%
145	Anus Neoplasms	5.2%
146	Sigmoid Neoplasms	5.2%
147	Colonic Pseudo-Obstruction	5.1%
148	Hepatolenticular Degeneration	4.9%
149	Cholestasis, Extrahepatic	4.9%
150	Biliary Dyskinesia	4.9%
151	Cholangitis, Sclerosing	4.9%
152	Colonic Diseases, Functional	4.9%
153	Esophageal motility disorders	4.9%
154	Fecal Incontinence	4.9%
155	Fecal Impaction	4.9%
156	Intussusception	4.9%
157	Mallory-Weiss Syndrome	4.9%
158	Megacolon	4.9%
159	Pyloric Stenosis	4.9%
160	Acalculous Cholecystitis	4.9%
161	Ileus	4.9%
162	Meconium ileus	4.9%
163	Enterocolitis, Pseudomembranous	4.9%
164	pseudomembranous colitis	4.9%
165	Dysentery, Bacillary	4.9%
166	Esophageal Perforation	4.8%
167	Intestinal Diseases, Parasitic	4.8%
168	Colitis, Ischemic	4.6%
169	Barrett Esophagus	4.5%
170	Deglutition Disorders	4.5%
171	Achlorhydria	4.4%
172	Pancreatic Pseudocyst	4.4%
173	Gastric Antral Vascular Ectasia	4.4%
174	Peptic Ulcer Hemorrhage	4.4%
175	Gastroparesis	4.4%
176	Pancreatitis, Alcoholic	4.4%
177	Cystic Fibrosis	4.2%
178	Adenomatous Polyposis Coli	4.2%
179	Esophageal Achalasia	4.1%
180	Anal Fissure	4.1%
181	Intestinal Pseudo-Obstruction	4.1%
182	Irritable Bowel Syndrome	4.1%
183	Superior Mesenteric Artery Syndrome	4.1%
184	Emphysematous Cholecystitis	4.1%
185	Neurogenic Bowel	4.1%
186	Sphincter of Oddi Dysfunction	4.1%
187	Anal Ulcer	4.1%
188	Congenital Hyperinsulinism	4.1%
189	Rift Valley Fever	3.6%
190	Hemorrhoids	3.4%
191	Melena	3.4%
192	Afferent Loop Syndrome	3.3%
193	Celiac Disease	3.3%
194	Short Bowel Syndrome	3.3%
195	Sprue, Tropical	3.3%
196	Steatorrhea	3.3%
197	Rectocele	3.3%
198	Sprue	3.3%
199	Hematemesis	3.3%
200	Carcinoma, Pancreatic Ductal	3.3%
201	Diverticulitis	3.3%
202	Dumping Syndrome	3.3%
203	Rectal Prolapse	3.3%
204	insulinoma	2.8%
205	Gastrinoma	2.8%
206	Glucagonoma	2.8%
207	Pruritus Ani	2.7%
208	Nesidioblastosis	2.6%
209	Giardiasis	2.6%
210	Laryngopharyngeal Reflux	2.5%
211	Diverticulum	2.5%
212	Diverticulosis	2.5%
213	Vipoma	2.4%
214	Peutz-Jeghers Syndrome	2%
215	Lactose Intolerance	2%
216	Cryptosporidiosis	1.4%
217	CREST Syndrome	1.2%

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