MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Intestinal Pseudo-Obstruction

(UMLS:C0021847)

Definition:: A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.
UMLS ID:: C0021847
MeSH ID:: D007418

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.531.492.500

Synonym(s)

Intestinal Pseudo-Obstruction

CONGENITAL SHORT BOWEL SYNDROME

Congenital short bowel syndrome

Enteric neuropathy

INTESTINE PSEUDO OBSTRUCTION

Intestinal pseudo-obstruction

Intestinal pseudoobstruction

Pseudo-obstruction of intestine

intestinal pseudo obstruction

10.

intestinal pseudo-obstruction

11.

intestinal pseudoobstruction

12.

pseudo intestinal obstruction

13.

pseudo obstruction intestinal

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Quetiapine Fumarate	FAERS: 3		US FAERS
2	Amoxicillin	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
3	Dexmedetomidine	FAERS: 2		US FAERS
4	Glatiramer Acetate	FAERS: 2		US FAERS
5	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
6	Bendamustine Hydrochloride	FAERS: 1		US FAERS
7	Bendamustine Hydrochloride	FAERS: 1		US FAERS
8	Clozapine	FAERS: 1 Canada Vigilance: 1	1860384	CTD Canada Vigilance US FAERS
9	Cyclosporine	FAERS: 1		US FAERS
10	Dexmedetomidine	FAERS: 1		US FAERS
11	Glatiramer Acetate	FAERS: 1		US FAERS
12	Haloperidol	FAERS: 1		US FAERS
13	Methadone	FAERS: 1		US FAERS
14	Morphine	FAERS: 1		US FAERS
15	Mycophenolic Acid	FAERS: 1		US FAERS
16	Olanzapine	FAERS: 1		US FAERS
17	Pyridostigmine Bromide	FAERS: 1		US FAERS
18	deflazacort	FAERS: 1		US FAERS
19	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
20	naloxegol	FAERS: 1		US FAERS
21	riociguat	FAERS: 1		US FAERS
22	Bepridil		6332516	CTD
23	Glycopyrrolate			SIDER
24	Itraconazole		17617780	CTD
25	Naproxen		285374	CTD
26	PCI 32765	Canada Vigilance: 1		Canada Vigilance
27	Sildenafil Citrate	Canada Vigilance: 1		Canada Vigilance
28	Vincristine		9434832	CTD
29	Vindesine		2312856 17617780	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Fecal Impaction	36%
2	Intussusception	36%
3	Meconium ileus	36%
4	Duodenal Obstruction	35.3%
5	Cecal Diseases	28.5%
6	Colonic Diseases	28.5%
7	Ileal Diseases	28.5%
8	Intestinal Perforation	28.5%
9	Jejunal Diseases	28.5%
10	Pneumatosis Cystoides Intestinalis	28.5%
11	Rectal Diseases	28.5%
12	Cronkhite-Canada Syndrome	28.5%
13	Intestinal Polyposis	28.5%
14	Dysentery	27.3%
15	Enteritis	27.3%
16	Enterocolitis	27.3%
17	Inflammatory Bowel Diseases	27.3%
18	Afferent Loop Syndrome	24.3%
19	Esophageal Diseases	22.7%
20	Gastroenteritis	22.7%
21	Stomach Diseases	22.7%
22	Duodenitis	20.5%
23	Ileitis	20.5%
24	Erosive Duodenitis	20.5%
25	Intestinal Diseases, Parasitic	20.5%
26	Colitis	19.5%
27	Duodenogastric Reflux	19.5%
28	Peptic Ulcer	19.5%
29	Proctitis	19.5%
30	Zollinger-Ellison syndrome	19.1%
31	Mesenteric vascular insufficiency	18.7%
32	Intestinal Atresia	18.4%
33	Mesenteric Vascular Occlusion	18.4%
34	Intestinal Fistula	18.3%
35	Enterocutaneous Fistula	18.3%
36	Intestinal Neoplasms	18%
37	Colorectal Neoplasms	17.2%
38	Colonic Diseases, Functional	16.8%
39	Fecal Incontinence	16.8%
40	Megacolon	16.8%
41	Esophagitis	16.4%
42	Gastritis	16.4%
43	Crohn Disease	16%
44	Enterocolitis, Neutropenic	16%
45	Necrotizing Enterocolitis	16%
46	Proctocolitis	16%
47	Gastrointestinal Neoplasms	15.3%
48	Biliary Tract Diseases	15.3%
49	Liver diseases	15.3%
50	Pancreatic Diseases	15.3%
51	Rectal Fistula	15.2%
52	Anal Fistula	15.2%
53	Gastrointestinal Hemorrhage	15.1%
54	Tuberculosis, Gastrointestinal	14.8%
55	Appendicitis	14.7%
56	Cecal Neoplasms	14.4%
57	Duodenal Neoplasms	14.4%
58	Pouchitis	13.5%
59	Duodenal Ulcer	12.2%
60	Peptic Ulcer Perforation	12.2%
61	Gastric ulcer	12.2%
62	Esophageal Stenosis	12.2%
63	Gastric Dilatation	12.2%
64	Gastric outlet obstruction	12.2%
65	Enterocolitis, Pseudomembranous	12%
66	pseudomembranous colitis	12%
67	Dysentery, Bacillary	12%
68	Hemorrhoids	11.6%
69	Stomach Neoplasms	11.5%
70	Celiac Disease	11.4%
71	Short Bowel Syndrome	11.4%
72	Sprue, Tropical	11.4%
73	Steatorrhea	11.4%
74	Rectocele	11.4%
75	Sprue	11.4%
76	Rectal Prolapse	11.2%
77	Anal Fissure	11.1%
78	Irritable Bowel Syndrome	11.1%
79	Superior Mesenteric Artery Syndrome	11.1%
80	Neurogenic Bowel	11.1%
81	Anal Ulcer	11.1%
82	Esophageal and Gastric Varices	10.9%
83	Digestive System Neoplasms	10.2%
84	Esophageal Atresia	10%
85	Esophageal Neoplasms	9.6%
86	Appendiceal Neoplasms	9.5%
87	Colonic Neoplasms	9.5%
88	Rectal Neoplasms	9.5%
89	Colitis, Ischemic	9.4%
90	Anus Neoplasms	9.2%
91	Sigmoid Neoplasms	9.2%
92	Adenomatous Polyposis Coli	9.2%
93	Giardiasis	8.9%
94	Esophageal Perforation	8.8%
95	Barrett Esophagus	8.4%
96	Deglutition Disorders	8.4%
97	Achlorhydria	8.2%
98	Gastric Antral Vascular Ectasia	8.2%
99	Gastrointestinal Stromal Tumors	8.2%
100	Peptic Ulcer Hemorrhage	8.1%
101	Gastroparesis	8.1%
102	Liver neoplasms	7.7%
103	Pancreatic Fistula	7.6%
104	Bile Duct Diseases	7.6%
105	Cholelithiasis	7.6%
106	Chylous Ascites	7.6%
107	Fatty Liver	7.6%
108	Hepatitis	7.6%
109	Portal Hypertension	7.6%
110	Liver Cirrhosis	7.6%
111	Pancreatic Insufficiency	7.6%
112	Pancreatitis	7.6%
113	Pneumoperitoneum	7.6%
114	Focal Nodular Hyperplasia	7.6%
115	Hepatic Insufficiency	7.6%
116	Steatohepatitis	7.6%
117	Pruritus Ani	7.5%
118	Colonic Pseudo-Obstruction	7.4%
119	Esophageal motility disorders	7.2%
120	Mallory-Weiss Syndrome	7.2%
121	Pyloric Stenosis	7.2%
122	Peutz-Jeghers Syndrome	6.9%
123	Lactose Intolerance	6.8%
124	Melena	6.2%
125	Peritoneal Neoplasms	6.1%
126	Hematemesis	6.1%
127	Cholecystolithiasis	5.5%
128	Liver Diseases, Parasitic	5.4%
129	Hepatic Veno-Occlusive Disease	5.1%
130	Pancreatic Cyst	5.1%
131	Peliosis Hepatis	5.1%
132	Hepatopulmonary Syndrome	5.1%
133	Pancreatic Neoplasm	5.1%
134	Anus, Imperforate	5%
135	Hemoperitoneum	5%
136	Hepatomegaly	5%
137	Mesenteric Panniculitis	5%
138	Panniculitis, Peritoneal	5%
139	Peritonitis	5%
140	Peritoneal Fibrosis	5%
141	Encapsulating Peritoneal Sclerosis	5%
142	Anorectal Malformations	5%
143	Cryptosporidiosis	5%
144	Biliary Fistula	5%
145	Gastric Fistula	5%
146	Hepatic Vein Thrombosis	4.9%
147	Liver Abscess	4.9%
148	Budd-Chiari Syndrome	4.9%
149	Bile Duct Neoplasms	4.9%
150	gallbladder neoplasm	4.9%
151	Biliary cirrhosis	4.9%
152	Diverticulitis	4.8%
153	Dumping Syndrome	4.8%
154	Esophageal Achalasia	4.8%
155	Choledochal Cyst	4.7%
156	Choledocholithiasis	4.3%
157	Cholangitis	4.1%
158	Cholecystitis	4.1%
159	Cholestasis	4.1%
160	Common Bile Duct Diseases	4.1%
161	Fatty Liver, Alcoholic	4.1%
162	Hepatitis, Alcoholic	4.1%
163	Hepatitis, Chronic	4.1%
164	Liver Cirrhosis, Alcoholic	4.1%
165	Liver Failure	4.1%
166	Pancreatitis, Chronic	4.1%
167	Non-alcoholic Fatty Liver Disease	4.1%
168	Chronic active hepatitis	4.1%
169	Chemical and Drug Induced Liver Injury	3.9%
170	Hepatorenal Syndrome	3.7%
171	Diverticulum	3.7%
172	Diverticulosis	3.7%
173	Hepatocellular Adenoma	3.3%
174	Cystic Fibrosis	3.1%
175	Porphyrias, Hepatic	3%
176	Congenital Hyperinsulinism	3%
177	Hepatitis, Animal	2.9%
178	Hepatitis, Viral, Human	2.9%
179	Liver Abscess, Amebic	2.8%
180	Liver Neoplasms, Experimental	2.8%
181	Liver Cirrhosis, Experimental	2.7%
182	Pancreatic Pseudocyst	2.7%
183	Pancreatitis, Alcoholic	2.7%
184	Laryngopharyngeal Reflux	2.5%
185	Cholestasis, Extrahepatic	2.4%
186	Biliary Dyskinesia	2.4%
187	Cholangitis, Sclerosing	2.4%
188	Liver Failure, Acute	2.4%
189	Acalculous Cholecystitis	2.4%
190	End Stage Liver Disease	2.4%
191	Fascioliasis	2.1%
192	Echinococcosis, Hepatic	2.1%
193	Chemical and Drug Induced Liver Injury, Chronic	2.1%
194	Reye Syndrome	2%
195	Carcinoma, Pancreatic Ductal	2%
196	Autoimmune hepatitis	1.7%
197	Nesidioblastosis	1.6%
198	Variegate Porphyria	1.6%
199	Acute intermittent porphyria	1.6%
200	Porphyria Cutanea Tarda	1.6%
201	Hepatitis B, Chronic	1.6%
202	Hepatitis C, Chronic	1.6%
203	Massive Hepatic Necrosis	1.6%
204	Emphysematous Cholecystitis	1.6%
205	Sphincter of Oddi Dysfunction	1.6%
206	CREST Syndrome	1.4%
207	insulinoma	1.4%
208	Gastrinoma	1.4%
209	Glucagonoma	1.4%
210	Zellweger Syndrome	1.3%
211	Hepatitis, Viral, Animal	1.3%
212	Hepatitis E	1.3%
213	Hepatitis B	1.2%
214	Hepatitis C	1.2%
215	Hepatitis A	1.2%
216	Hepatolenticular Degeneration	1.2%
217	Hepatic Encephalopathy	1.2%
218	Vipoma	1.2%
219	Rift Valley Fever	0.5%

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