MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anal Ulcer

(UMLS:C4759657)

Definition:: A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)
UMLS ID:: C4759657
MeSH ID:: D005401

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.860.101.430

Synonym(s)

Anal Ulcer

ANAL ULCER

Anal mucosal ulcer

Anal ulcer

Ulcer of anus

anal ulcer

anal ulcer (___ cm)

anal ulcers

anus; ulcer

10.

ulcer of anus

11.

ulcer; anus

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Isotretinoin	FAERS: 25	US FAERS
2	Sunitinib	FAERS: 16	US FAERS
3	Diclofenac	FAERS: 12	US FAERS
4	Sorafenib	FAERS: 7	US FAERS
5	Imatinib Mesylate	FAERS: 4	US FAERS
6	Methotrexate	FAERS: 4	US FAERS
7	Dabigatran	FAERS: 3	US FAERS
8	Pemetrexed	FAERS: 3	US FAERS
9	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2	US FAERS
10	Arthrotec	FAERS: 2	US FAERS
11	Bromocriptine	FAERS: 2	US FAERS
12	Capecitabine	FAERS: 2	US FAERS
13	Clofarabine	FAERS: 2	US FAERS
14	Ibuprofen	FAERS: 2	US FAERS
15	Mycophenolic Acid	FAERS: 2	US FAERS
16	PCI 32765	FAERS: 2	US FAERS
17	Sirolimus	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
18	cabozantinib	FAERS: 2	US FAERS
19	regorafenib	FAERS: 2	US FAERS
20	Acyclovir	FAERS: 1	US FAERS
21	Atomoxetine Hydrochloride	FAERS: 1	US FAERS
22	Azacitidine	FAERS: 1	US FAERS
23	Cabozantinib S-malate	FAERS: 1	US FAERS
24	Ciprofloxacin	FAERS: 1	US FAERS
25	Cytarabine	FAERS: 1	US FAERS
26	Dasatinib	FAERS: 1	US FAERS
27	Erlotinib Hydrochloride	FAERS: 1	US FAERS
28	Everolimus	FAERS: 1	US FAERS
29	Glatiramer Acetate	FAERS: 1	US FAERS
30	Invokamet	FAERS: 1	US FAERS
31	Letrozole	FAERS: 1	US FAERS
32	Paclitaxel	FAERS: 1	US FAERS
33	Prednisone	FAERS: 1	US FAERS
34	Propylthiouracil	FAERS: 1	US FAERS
35	Roflumilast	FAERS: 1	US FAERS
36	Sulfasalazine	FAERS: 1	US FAERS
37	mirabegron	FAERS: 1	US FAERS
38	rofecoxib	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Fecal Incontinence	36%
2	Pruritus Ani	33.3%
3	Proctitis	32.4%
4	Cecal Diseases	28.5%
5	Colonic Diseases	28.5%
6	Ileal Diseases	28.5%
7	Intestinal Obstruction	28.5%
8	Intestinal Perforation	28.5%
9	Jejunal Diseases	28.5%
10	Pneumatosis Cystoides Intestinalis	28.5%
11	Cronkhite-Canada Syndrome	28.5%
12	Intestinal Polyposis	28.5%
13	Dysentery	27.3%
14	Enteritis	27.3%
15	Enterocolitis	27.3%
16	Inflammatory Bowel Diseases	27.3%
17	Hemorrhoids	24.9%
18	Rectocele	24.3%
19	Rectal Prolapse	24.1%
20	Rectal Fistula	22.9%
21	Anal Fistula	22.9%
22	Anus Neoplasms	22.8%
23	Colorectal Neoplasms	22.7%
24	Esophageal Diseases	22.7%
25	Gastroenteritis	22.7%
26	Stomach Diseases	22.7%
27	Duodenal Obstruction	22.5%
28	Duodenitis	20.5%
29	Ileitis	20.5%
30	Erosive Duodenitis	20.5%
31	Intestinal Diseases, Parasitic	20.5%
32	Proctocolitis	20.2%
33	Colitis	19.5%
34	Duodenogastric Reflux	19.5%
35	Peptic Ulcer	19.5%
36	Zollinger-Ellison syndrome	19.1%
37	Mesenteric vascular insufficiency	18.7%
38	Intestinal Atresia	18.4%
39	Mesenteric Vascular Occlusion	18.4%
40	Intestinal Fistula	18.3%
41	Enterocutaneous Fistula	18.3%
42	Intestinal Neoplasms	18%
43	Colonic Diseases, Functional	16.8%
44	Fecal Impaction	16.8%
45	Intussusception	16.8%
46	Megacolon	16.8%
47	Ileus	16.8%
48	Meconium ileus	16.8%
49	Esophagitis	16.4%
50	Gastritis	16.4%
51	Crohn Disease	16%
52	Enterocolitis, Neutropenic	16%
53	Necrotizing Enterocolitis	16%
54	Gastrointestinal Neoplasms	15.3%
55	Biliary Tract Diseases	15.3%
56	Liver diseases	15.3%
57	Pancreatic Diseases	15.3%
58	Gastrointestinal Hemorrhage	15.1%
59	Tuberculosis, Gastrointestinal	14.8%
60	Appendicitis	14.7%
61	Cecal Neoplasms	14.4%
62	Duodenal Neoplasms	14.4%
63	Rectal Neoplasms	13.7%
64	Pouchitis	13.5%
65	Colonic Pseudo-Obstruction	12.9%
66	Duodenal Ulcer	12.2%
67	Peptic Ulcer Perforation	12.2%
68	Gastric ulcer	12.2%
69	Esophageal Stenosis	12.2%
70	Gastric Dilatation	12.2%
71	Gastric outlet obstruction	12.2%
72	Enterocolitis, Pseudomembranous	12%
73	pseudomembranous colitis	12%
74	Dysentery, Bacillary	12%
75	Stomach Neoplasms	11.5%
76	Afferent Loop Syndrome	11.4%
77	Celiac Disease	11.4%
78	Short Bowel Syndrome	11.4%
79	Sprue, Tropical	11.4%
80	Steatorrhea	11.4%
81	Sprue	11.4%
82	Intestinal Pseudo-Obstruction	11.1%
83	Irritable Bowel Syndrome	11.1%
84	Superior Mesenteric Artery Syndrome	11.1%
85	Neurogenic Bowel	11.1%
86	Esophageal and Gastric Varices	10.9%
87	Digestive System Neoplasms	10.2%
88	Esophageal Atresia	10%
89	Esophageal Neoplasms	9.6%
90	Appendiceal Neoplasms	9.5%
91	Colonic Neoplasms	9.5%
92	Colitis, Ischemic	9.4%
93	Sigmoid Neoplasms	9.2%
94	Adenomatous Polyposis Coli	9.2%
95	Giardiasis	8.9%
96	Esophageal Perforation	8.8%
97	Barrett Esophagus	8.4%
98	Deglutition Disorders	8.4%
99	Achlorhydria	8.2%
100	Gastric Antral Vascular Ectasia	8.2%
101	Gastrointestinal Stromal Tumors	8.2%
102	Peptic Ulcer Hemorrhage	8.1%
103	Gastroparesis	8.1%
104	Liver neoplasms	7.7%
105	Pancreatic Fistula	7.6%
106	Bile Duct Diseases	7.6%
107	Cholelithiasis	7.6%
108	Chylous Ascites	7.6%
109	Fatty Liver	7.6%
110	Hepatitis	7.6%
111	Portal Hypertension	7.6%
112	Liver Cirrhosis	7.6%
113	Pancreatic Insufficiency	7.6%
114	Pancreatitis	7.6%
115	Pneumoperitoneum	7.6%
116	Focal Nodular Hyperplasia	7.6%
117	Hepatic Insufficiency	7.6%
118	Steatohepatitis	7.6%
119	Esophageal motility disorders	7.2%
120	Mallory-Weiss Syndrome	7.2%
121	Pyloric Stenosis	7.2%
122	Peutz-Jeghers Syndrome	6.9%
123	Lactose Intolerance	6.8%
124	Melena	6.2%
125	Peritoneal Neoplasms	6.1%
126	Hematemesis	6.1%
127	Cholecystolithiasis	5.5%
128	Liver Diseases, Parasitic	5.4%
129	Hepatic Veno-Occlusive Disease	5.1%
130	Pancreatic Cyst	5.1%
131	Peliosis Hepatis	5.1%
132	Hepatopulmonary Syndrome	5.1%
133	Pancreatic Neoplasm	5.1%
134	Anus, Imperforate	5%
135	Hemoperitoneum	5%
136	Hepatomegaly	5%
137	Mesenteric Panniculitis	5%
138	Panniculitis, Peritoneal	5%
139	Peritonitis	5%
140	Peritoneal Fibrosis	5%
141	Encapsulating Peritoneal Sclerosis	5%
142	Anorectal Malformations	5%
143	Cryptosporidiosis	5%
144	Biliary Fistula	5%
145	Gastric Fistula	5%
146	Hepatic Vein Thrombosis	4.9%
147	Liver Abscess	4.9%
148	Budd-Chiari Syndrome	4.9%
149	Bile Duct Neoplasms	4.9%
150	gallbladder neoplasm	4.9%
151	Biliary cirrhosis	4.9%
152	Diverticulitis	4.8%
153	Dumping Syndrome	4.8%
154	Esophageal Achalasia	4.8%
155	Choledochal Cyst	4.7%
156	Choledocholithiasis	4.3%
157	Cholangitis	4.1%
158	Cholecystitis	4.1%
159	Cholestasis	4.1%
160	Common Bile Duct Diseases	4.1%
161	Fatty Liver, Alcoholic	4.1%
162	Hepatitis, Alcoholic	4.1%
163	Hepatitis, Chronic	4.1%
164	Liver Cirrhosis, Alcoholic	4.1%
165	Liver Failure	4.1%
166	Pancreatitis, Chronic	4.1%
167	Non-alcoholic Fatty Liver Disease	4.1%
168	Chronic active hepatitis	4.1%
169	Chemical and Drug Induced Liver Injury	3.9%
170	Hepatorenal Syndrome	3.7%
171	Diverticulum	3.7%
172	Diverticulosis	3.7%
173	Hepatocellular Adenoma	3.3%
174	Cystic Fibrosis	3.1%
175	Porphyrias, Hepatic	3%
176	Congenital Hyperinsulinism	3%
177	Hepatitis, Animal	2.9%
178	Hepatitis, Viral, Human	2.9%
179	Liver Abscess, Amebic	2.8%
180	Liver Neoplasms, Experimental	2.8%
181	Liver Cirrhosis, Experimental	2.7%
182	Pancreatic Pseudocyst	2.7%
183	Pancreatitis, Alcoholic	2.7%
184	Laryngopharyngeal Reflux	2.5%
185	Cholestasis, Extrahepatic	2.4%
186	Biliary Dyskinesia	2.4%
187	Cholangitis, Sclerosing	2.4%
188	Liver Failure, Acute	2.4%
189	Acalculous Cholecystitis	2.4%
190	End Stage Liver Disease	2.4%
191	Fascioliasis	2.1%
192	Echinococcosis, Hepatic	2.1%
193	Chemical and Drug Induced Liver Injury, Chronic	2.1%
194	Reye Syndrome	2%
195	Carcinoma, Pancreatic Ductal	2%
196	Autoimmune hepatitis	1.7%
197	Nesidioblastosis	1.6%
198	Variegate Porphyria	1.6%
199	Acute intermittent porphyria	1.6%
200	Porphyria Cutanea Tarda	1.6%
201	Hepatitis B, Chronic	1.6%
202	Hepatitis C, Chronic	1.6%
203	Massive Hepatic Necrosis	1.6%
204	Emphysematous Cholecystitis	1.6%
205	Sphincter of Oddi Dysfunction	1.6%
206	CREST Syndrome	1.4%
207	insulinoma	1.4%
208	Gastrinoma	1.4%
209	Glucagonoma	1.4%
210	Zellweger Syndrome	1.3%
211	Hepatitis, Viral, Animal	1.3%
212	Hepatitis E	1.3%
213	Hepatitis B	1.2%
214	Hepatitis C	1.2%
215	Hepatitis A	1.2%
216	Hepatolenticular Degeneration	1.2%
217	Hepatic Encephalopathy	1.2%
218	Vipoma	1.2%
219	Rift Valley Fever	0.5%

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