MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Penicillamine

(VVNCNSJFMMFHPL-VKHMYHEASA-N)

Structure

SMILES: N[C@H](C(S)(C)C)C(=O)O
Type(s): Approved
ATC code(s): M01CC01
Molecular Formula:: C5H11NO2S
Molecular Weight:: 149.211
Log P:: 0.8070
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 3
TPSA:: 102.12
CAS Number(s):: 52-67-5; 771431-20-0

Synonym(s)

Penicillamine

Dimethylcysteine

Mercaptovaline

beta,beta-Dimethylcysteine

Copper Penicillaminate

Cuprenil

Cuprimine

D-3-Mercaptovaline

D-Penicillamine

10.

Metalcaptase

11.

D 3 Mercaptovaline

12.

D Penicillamine

13.

Penicillaminate, Copper

14.

beta,beta Dimethylcysteine

External Link(s)

MeSH	D010396
PubChem Compound	5852 6926437
BindingDB	50217941 39346
ChEBI	7959
CHEMBL	CHEMBL1430
DrugBank	DB00859
DrugCentral	2081
IUPHAR/BPS Guide to PHARMACOLOGY	7264
KEGG	cpd:C07418 dr:D00496
Therapeutic Target Database	D0E2GG D08HZC
ZINC	100509167 114127

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cutis Laxa	FAERS: 8		OFFSIDES US FAERS
2	Dystonia	FAERS: 8	View details 2334309 3579660 9476721 11391761	CTD OFFSIDES US FAERS
3	Drug dose omission	FAERS: 7		US FAERS
4	Adverse event	FAERS: 6		OFFSIDES US FAERS
5	Drug exposure during pregnancy	FAERS: 6		OFFSIDES US FAERS
6	Hypersensitivity	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
7	Influenza	FAERS: 6		US FAERS
8	Anti-neutrophil cytoplasmic antibody positive vasculitis	FAERS: 5		US FAERS
9	Anxiety	FAERS: 5		SIDER US FAERS
10	Drug ineffective	FAERS: 5		US FAERS
11	Erythema	FAERS: 5 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
12	Fatigue	FAERS: 5	6419855	CTD US FAERS
13	Headache	FAERS: 5		US FAERS
14	Nausea	FAERS: 5 Canada Vigilance: 1	View details 769707 3977424 4119168 4216306 4853253 5071635 7420683	CTD SIDER Canada Vigilance US FAERS
15	Asthenia	FAERS: 4	745827	CTD US FAERS
16	Breast hyperplasia	FAERS: 4		OFFSIDES US FAERS
17	Cerebral atrophy	FAERS: 4		OFFSIDES US FAERS
18	Cytopenia	FAERS: 4		US FAERS
19	Musculoskeletal stiffness	FAERS: 4		OFFSIDES US FAERS
20	Pain	FAERS: 4	4723471	CTD US FAERS
21	Tremor	FAERS: 4	9476721	CTD US FAERS
22	Anorexia	FAERS: 3	4216306 5241672 5694119	CTD OFFSIDES SIDER US FAERS
23	Dementia	FAERS: 3		US FAERS
24	Dysarthria	FAERS: 3	View details 122656 287196 2334309 3579660	CTD US FAERS
25	Electrolyte imbalance	FAERS: 3		US FAERS
26	Epistaxis	FAERS: 3		US FAERS
27	Febrile Neutropenia	FAERS: 3		US FAERS
28	Feeling abnormal	FAERS: 3		US FAERS
29	Lung cyst	FAERS: 3		US FAERS
30	Nephrotic Syndrome	FAERS: 3	View details 48830 141075 536182 623127 626709 848141 960872 1005658 1172464 1221947 2082056 2334179 2947217 3823508 3963062 4169108 4188283 4742512 5645186 5927925 5953529 6151882 6335562 6641549 6939879 8259463 9132654 9860423 15500140	CTD OFFSIDES SIDER US FAERS
31	Onychoclasis	FAERS: 3		OFFSIDES US FAERS
32	Pain of skin	FAERS: 3		OFFSIDES US FAERS
33	Pancytopenia	FAERS: 3	View details 228408 4056558 8055207 15863969	CTD SIDER US FAERS
34	Pemphigus	FAERS: 3	View details 74171 485579 626709 2938530 2939913 2952797 3396226 6590007 6723128 7370063 8463474 8592607 10352832	CTD SIDER US FAERS
35	Pneumonia	FAERS: 3		US FAERS
36	Product dose omission	FAERS: 3		US FAERS
37	Therapy cessation	FAERS: 3		US FAERS
38	Torticollis	FAERS: 3		US FAERS
39	Toxicity to various agents	FAERS: 3		US FAERS
40	Vasculitis	FAERS: 3	View details 760401 6134831 6339966 9182889 17954295	CTD SIDER US FAERS
41	Vomiting	FAERS: 3	View details 769707 4119168 4216306 5071635 7420683	CTD SIDER US FAERS
42	Weight decreased	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
43	Abdominal discomfort	FAERS: 2		US FAERS
44	Anticoagulation drug level above therapeutic	FAERS: 2		US FAERS
45	Aspergillosis	FAERS: 2		OFFSIDES US FAERS
46	Blood cholesterol increased	FAERS: 2		US FAERS
47	Bone marrow depression	FAERS: 2		OFFSIDES SIDER US FAERS
48	Cerebrovascular accident	FAERS: 2		US FAERS
49	Cholestasis	FAERS: 2	View details 436073 629612 3759835 3843250 4048879 6179735 7213433 7253120	CTD SIDER US FAERS
50	Completed Suicide	FAERS: 2		OFFSIDES US FAERS
51	Conjunctivitis	FAERS: 2		US FAERS
52	Diabetes Mellitus	FAERS: 2		US FAERS
53	Dizziness	FAERS: 2		US FAERS
54	Drooling	FAERS: 2		US FAERS
55	General physical health deterioration	FAERS: 2		OFFSIDES US FAERS
56	General symptom	FAERS: 2		OFFSIDES US FAERS
57	Intentional product use issue	FAERS: 2		US FAERS
58	Iron deficiency	FAERS: 2		SIDER US FAERS
59	Joint swelling	FAERS: 2		US FAERS
60	Neutropenia	FAERS: 2	769707 2938530	CTD US FAERS
61	No adverse event	FAERS: 2		US FAERS
62	Oligohydramnios	FAERS: 2		US FAERS
63	Pancreatic Cyst	FAERS: 2		US FAERS
64	Paranoia	FAERS: 2		OFFSIDES US FAERS
65	Product availability issue	FAERS: 2		US FAERS
66	Product use in unapproved indication	FAERS: 2		US FAERS
67	Restrictive cardiomyopathy	FAERS: 2		US FAERS
68	Restrictive pulmonary disease	FAERS: 2		US FAERS
69	Scleroderma	FAERS: 2		OFFSIDES US FAERS
70	Sepsis	FAERS: 2		US FAERS
71	Skin Induration	FAERS: 2		OFFSIDES US FAERS
72	Skin Wrinkling	FAERS: 2		OFFSIDES SIDER US FAERS
73	Therapy non-responder	FAERS: 2		OFFSIDES US FAERS
74	Urinary Incontinence	FAERS: 2		US FAERS
75	Urticaria	FAERS: 2 Canada Vigilance: 2	5953529	CTD SIDER Canada Vigilance US FAERS
76	Abasia	FAERS: 1		US FAERS
77	Abnormal palmar/plantar creases	FAERS: 1		US FAERS
78	Acquired cystic kidney disease	FAERS: 1		US FAERS
79	Acquired pyloric stenosis	FAERS: 1		US FAERS
80	Acute kidney injury	FAERS: 1	View details 848141 1886219 2082056 3823508 4014326	CTD US FAERS
81	Acute respiratory failure	FAERS: 1		OFFSIDES US FAERS
82	Ageusia	FAERS: 1	5241672 5694119 6718787	CTD SIDER US FAERS
83	Alopecia	FAERS: 1		SIDER US FAERS
84	Amnesia	FAERS: 1		US FAERS
85	Anaphylactic shock	FAERS: 1		US FAERS
86	Aphasia	FAERS: 1		US FAERS
87	Arthritis	FAERS: 1	1189496	CTD US FAERS
88	Arthropathy	FAERS: 1		US FAERS
89	Asthma	FAERS: 1		SIDER US FAERS
90	Atelectasis	FAERS: 1		US FAERS
91	Bedridden	FAERS: 1		OFFSIDES US FAERS
92	Blood albumin decreased	FAERS: 1		US FAERS
93	Blood blister	FAERS: 1		US FAERS
94	Blood copper decreased	FAERS: 1		US FAERS
95	Blood copper increased	FAERS: 1		US FAERS
96	Blood glucose increased	FAERS: 1		US FAERS
97	Blood immunoglobulin A decreased	FAERS: 1		US FAERS
98	Bone pain	FAERS: 1		US FAERS
99	Bradykinesia	FAERS: 1		US FAERS
100	Bronchial Obstruction	FAERS: 1		US FAERS
101	Bronchiolitis	FAERS: 1		OFFSIDES US FAERS
102	Bronchopulmonary Aspergillosis	FAERS: 1		US FAERS
103	Bronchopulmonary Dysplasia	FAERS: 1		US FAERS
104	CREST Syndrome	FAERS: 1		US FAERS
105	Cardiac Arrest	FAERS: 1		US FAERS
106	Cleft Palate	FAERS: 1		OFFSIDES US FAERS
107	Clumsiness	FAERS: 1		US FAERS
108	Cogwheel Rigidity	FAERS: 1		US FAERS
109	Complex partial seizures	FAERS: 1		US FAERS
110	Congenital cutis laxa	FAERS: 1		US FAERS
111	Congenital deformity of clavicle	FAERS: 1		US FAERS
112	Constipation	FAERS: 1		US FAERS
113	Disability	FAERS: 1		US FAERS
114	Discomfort	FAERS: 1		US FAERS
115	Disease recurrence	FAERS: 1		US FAERS
116	Documented hypersensitivity to administered product	FAERS: 1		US FAERS
117	Drug effect incomplete	FAERS: 1		US FAERS
118	Drug prescribing error	FAERS: 1		US FAERS
119	Drug resistance	FAERS: 1		US FAERS
120	Drug screen positive	FAERS: 1		US FAERS
121	Duodenal Ulcer	FAERS: 1		US FAERS
122	Dysgeusia	FAERS: 1 Canada Vigilance: 1	2938530 3905561 5694119	CTD SIDER Canada Vigilance US FAERS
123	Dyspepsia	FAERS: 1	623127 769707 5488219	CTD US FAERS
124	Emotional distress	FAERS: 1		US FAERS
125	Epidermolysis Bullosa	FAERS: 1		US FAERS
126	Erectile dysfunction	FAERS: 1		US FAERS
127	Eructation	FAERS: 1		US FAERS
128	Eye ulcer	FAERS: 1		US FAERS
129	Fibroadenoma of breast	FAERS: 1		US FAERS
130	Gastrointestinal motility disorder	FAERS: 1		US FAERS
131	Hepatitis C antibody positive	FAERS: 1		US FAERS
132	Hepatitis C virus	FAERS: 1		US FAERS
133	Hepatitis	FAERS: 1	536182 7253120 18092909	CTD US FAERS
134	Hirsutism	FAERS: 1		US FAERS
135	Hydrocephalus	FAERS: 1		US FAERS
136	Hypotension	FAERS: 1		US FAERS
137	Hypothalamo-pituitary disorder	FAERS: 1		US FAERS
138	Hypothyroidism	FAERS: 1		US FAERS
139	Hypoventilation	FAERS: 1		US FAERS
140	Immune thrombocytopenic purpura	FAERS: 1		US FAERS
141	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
142	Incorrect dose administered	FAERS: 1		US FAERS
143	Intestinal diaphragm disease	FAERS: 1		US FAERS
144	Lethargy	FAERS: 1	7445978	CTD US FAERS
145	Leukodystrophy	FAERS: 1		US FAERS
146	Leukopenia	FAERS: 1 Canada Vigilance: 1	View details 228408 2939913 5241672 5953529	CTD SIDER Canada Vigilance US FAERS
147	Lung consolidation	FAERS: 1		US FAERS
148	Lymphocytic infiltration	FAERS: 1		US FAERS
149	Malaise	FAERS: 1		US FAERS
150	Mental status changes	FAERS: 1		US FAERS
151	Micrographia	FAERS: 1		US FAERS
152	Multiple Sclerosis	FAERS: 1		US FAERS
153	Muscle Rigidity	FAERS: 1	9476721	CTD US FAERS
154	Myasthenia Gravis	FAERS: 1	View details 78009 122656 287196 420710 458795 567304 571557 628198 673084 732905 745827 756327 921089 930944 966573 976101 1125624 1139195 1604135 1948449 2001604 2144538 2464451 2682299 2692700 2935832 2938530 2939913 2952797 3451832 3492852 3589994 3662740 3738397 3750012 3751350 3768231 3813503 3966521 4018948 6216862 6252512 6402089 6403127 6419855 6450409 6481374 6531741 6535556 6578008 6605118 6636079 6658398 6689658 6699910 6714116 6723128 6855800 6884397 6951482 7012074 7099199 7099959 7127905 7163666 7230162 7255126 7280897 7282112 7288965 7313901 7316342 7370063 7404801 7420683 7425327 7457085 7697959 7835005 7900739 8000404 8164222 8209208 8403583 8463474 8497752 8588126 8592607 8618573 8709903 8722166 9077501 9922674 10352832 10408968 10999174	CTD SIDER US FAERS
155	Nasopharyngitis	FAERS: 1		US FAERS
156	Necrosis	FAERS: 1		US FAERS
157	Nephrolithiasis	FAERS: 1		US FAERS
158	Neurological decompensation	FAERS: 1		US FAERS
159	Nocturia	FAERS: 1		US FAERS
160	Opisthotonus	FAERS: 1		US FAERS
161	Oropharyngeal pain	FAERS: 1		US FAERS
162	Osteomyelitis	FAERS: 1		US FAERS
163	Pericardial effusion	FAERS: 1		US FAERS
164	Peripheral swelling	FAERS: 1		US FAERS
165	Polyarthritis	FAERS: 1		US FAERS
166	Polydactyly	FAERS: 1		OFFSIDES US FAERS
167	Polyneuropathy	FAERS: 1		US FAERS
168	Posturing	FAERS: 1		US FAERS
169	Product dispensing error	FAERS: 1		US FAERS
170	Product distribution issue	FAERS: 1		US FAERS
171	Product lot number issue	FAERS: 1		US FAERS
172	Product packaging quantity issue	FAERS: 1		US FAERS
173	Product physical issue	FAERS: 1		US FAERS
174	Product quality issue	FAERS: 1		US FAERS
175	Product storage error	FAERS: 1		US FAERS
176	Product use issue	FAERS: 1		US FAERS
177	Progeria	FAERS: 1		US FAERS
178	Pseudoxanthoma Elasticum	FAERS: 1		US FAERS
179	Psoriasis	FAERS: 1		US FAERS
180	Psychiatric symptom	FAERS: 1		US FAERS
181	Pulmonary malformation	FAERS: 1		OFFSIDES US FAERS
182	Purpura	FAERS: 1		US FAERS
183	Renal cyst	FAERS: 1		US FAERS
184	Respiratory distress	FAERS: 1		US FAERS
185	Restless Legs Syndrome	FAERS: 1		US FAERS
186	Rheumatoid Arthritis	FAERS: 1		US FAERS
187	Seronegative arthritis	FAERS: 1		US FAERS
188	Single umbilical artery	FAERS: 1		US FAERS
189	Sjogren's Syndrome	FAERS: 1		US FAERS
190	Skin nodule	FAERS: 1		US FAERS
191	Status Epilepticus	FAERS: 1		US FAERS
192	Stevens-Johnson Syndrome	FAERS: 1	1172464 25811541	CTD US FAERS
193	Stomatitis	FAERS: 1		SIDER US FAERS
194	Swelling	FAERS: 1		US FAERS
195	Syncope	FAERS: 1		US FAERS
196	Syndactyly	FAERS: 1		OFFSIDES US FAERS
197	Talipes	FAERS: 1		US FAERS
198	Thrombocytopenia	FAERS: 1 Canada Vigilance: 4	View details 228408 294903 310574 769707 1154051 2938530 3437418 3459889 4119168 4216306 4532634 5241672 5953529 6151882 7362666 10555917	CTD SIDER Canada Vigilance US FAERS
199	Umbilical cord vascular disorder	FAERS: 1		US FAERS
200	Unevaluable event	FAERS: 1		US FAERS
201	Unresponsive to stimuli	FAERS: 1		US FAERS
202	Urinary sediment present	FAERS: 1		US FAERS
203	Urine copper increased	FAERS: 1		US FAERS
204	Urine flow decreased	FAERS: 1		US FAERS
205	jaundice	FAERS: 1	2774703 6179735 7253120	CTD US FAERS
206	Actinic keratosis			OFFSIDES
207	Adrenogenital Syndrome			OFFSIDES
208	Agitation			SIDER
209	Agranulocytosis		5488219 7313901	CTD SIDER
210	Albuminuria		5488219	CTD
211	Alkaline phosphatase serum increased			SIDER
212	Amphetamines			OFFSIDES
213	Anemia, Hemolytic		49598 1154051	CTD
214	Anemia		228408 10555917 11149553	CTD
215	Anti-Glomerular Basement Membrane Disease		View details 1094875 1247260 3587472 6945838 7043674 7099337 7370063 7380177 8592607 12858467	CTD
216	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis		8592607 10693882	CTD
217	Aortic Diseases		6186262 6666578	CTD
218	Apnea		3768231	CTD
219	Arthralgia	Canada Vigilance: 1		Canada Vigilance SIDER
220	Arthritis, Experimental		290353 4014226	CTD
221	Arthritis, Psoriatic		1775410	CTD
222	Arthritis, Reactive		3396226	CTD
223	Ascites			OFFSIDES
224	Autoimmune Diseases		View details 2407537 3097874 6365381 7664789 8125139 9022032 11222498 21227906	CTD
225	Autoimmune hepatitis			OFFSIDES
226	Back Pain	Canada Vigilance: 1		Canada Vigilance
227	Band neutrophil percentage increased			OFFSIDES
228	Basal Ganglia Diseases		12839386	CTD
229	Basal cell carcinoma			OFFSIDES
230	Blepharoptosis		View details 122656 287196 717993 745827 921089 1139195 2144538 6419855 6605118 7420683 8164222 8463474	CTD
231	Blood alkaline phosphatase increased	Canada Vigilance: 1		Canada Vigilance SIDER
232	Blood and lymphatic system disorders			SIDER
233	Blood brain barrier defect			OFFSIDES
234	Blood creatinine decreased			OFFSIDES
235	Blood gases abnormal			OFFSIDES
236	Blood lactate dehydrogenase increased			OFFSIDES
237	Blood sodium			OFFSIDES
238	Blood urea increased			OFFSIDES
239	Bone Marrow Diseases		2952797	CTD
240	Bone formation decreased			OFFSIDES
241	Brain Diseases		2617716	CTD
242	Bronchiolitis Obliterans		6723128 7043674	CTD
243	Bronchoalveolar Lavage			OFFSIDES
244	Candida serology positive			OFFSIDES
245	Catheter related infection			OFFSIDES
246	Cheilosis			SIDER
247	Chemical and Drug Induced Liver Injury		View details 629612 2774703 3375535 3605968 3704507 3997313 4048879 5055042 6981100 11394653 19715684 23220588 24085192	CTD
248	Chromaturia	Canada Vigilance: 1		Canada Vigilance
249	Circumstance or information capable of leading to medication error			OFFSIDES
250	Cirrhosis			OFFSIDES
251	Colitis			OFFSIDES
252	Confabulation			OFFSIDES
253	Connective Tissue Diseases		4042411	CTD
254	Contracture			OFFSIDES
255	Cryptorchidism			OFFSIDES
256	Cystinuria		View details 3752071 4048879 4169108 5641080 5694119 5953529 6027079 7342491 7370063 22843330	CTD
257	Cystitis		6530353	CTD
258	Deafness Neurosensory			OFFSIDES
259	Deglutition Disorders		View details 122656 287196 745827 2025947 6830075	CTD
260	Demyelinating Diseases		2327244	CTD
261	Dermatitis, Allergic Contact		13761469	CTD
262	Dermatitis		6365381	CTD SIDER
263	Dermatomyositis		View details 94219 705267 843119 1411195 2001908 2403408 3501473 6592972 6658398 6830075 7452649 18625537	CTD SIDER
264	Device related infection			OFFSIDES
265	Diplopia		View details 78009 122656 287196 531355 745827 921089 2144538 3751350 6419855 6481374 6605118 7420683 8463474	CTD
266	Disease Progression			OFFSIDES
267	Disseminated Intravascular Coagulation		6365381	CTD
268	Drug Eruptions		4853253	CTD
269	Drug-induced lupus erythematosus			SIDER
270	Dysmorphism			OFFSIDES
271	Dyspnea		2939913 4853253	CTD
272	Eczema	Canada Vigilance: 1		Canada Vigilance
273	Edema		7452649	CTD
274	Ejection Fraction Decreased			OFFSIDES
275	Endocarditis			OFFSIDES
276	Endophthalmitis			OFFSIDES
277	Endotoxic shock			OFFSIDES
278	Eosinophilia		228408 4853253 9077501	CTD SIDER
279	Eosinophilic Pneumonia			OFFSIDES
280	Epigastric pain			SIDER
281	Epilepsy		3579660	CTD
282	Erythema Multiforme	Canada Vigilance: 1		Canada Vigilance
283	Escherichia urinary tract infection			OFFSIDES
284	Evans syndrome		1925397	CTD
285	Exanthema		View details 144507 310574 623127 769707 1833009 2938530 2952797 3905561 4048879 4119168 5488219 6216862 6451203 6451692 6460054 7342491 7362666 7452649 8463474	CTD
286	Extravasation			SIDER
287	Eyelid Diseases		966573	CTD
288	Fasciitis		9077501	CTD
289	Fatty Liver		7445978	CTD
290	Feeding and Eating Disorders		290353 4853253	CTD
291	Fetal Diseases		2617716	CTD
292	Fever		View details 1833009 2939913 2952797 4048879 4853253 5953529 7342491	CTD
293	Gastrointestinal Diseases		691197 2939913 2952797	CTD
294	Gastrointestinal amyloidosis			OFFSIDES
295	Gingivostomatitis			SIDER
296	Glomerulonephritis		View details 122655 141075 161403 536182 760401 848141 994834 1195663 3430507 3576513 3752071 4014326 6129465 6339966 7445978 8267029 9426850 9551449 9989295 10228478 10616290 10644924	CTD OFFSIDES SIDER
297	Glossitis			SIDER
298	Guillain-Barre Syndrome		6590007	CTD SIDER
299	Haptoglobin Decreased			OFFSIDES
300	Heart Block		2591396 4056558 8187449	CTD
301	Heart Diseases		6830075	CTD
302	Hemarthrosis		4014226	CTD
303	Hematuria		View details 1195663 4014326 6719300 6945838 11149553	CTD
304	Hemoptysis		1314978 3430507	CTD
305	Hemorrhage		View details 1094875 3576513 6945838 9989295	CTD
306	Hepatic necrosis			OFFSIDES
307	Hepatitis C			OFFSIDES
308	Hepatitis, Chronic		48830 25053573	CTD
309	Hepatolenticular Degeneration		View details 161403 287196 736410 819461 930944 960872 1139195 1212597 1428152 1466536 1794180 1940953 2045766 2334309 2732577 3579660 3752071 4116745 4188283 4572368 4632215 5149266 5421930 5927925 5953529 6658398 6939878 7370063 7710368 7792379 7849148 8129644 8592607 8618573 8832611 9311362 9476721 9860423 10999174 11391761 11585717 12839386 14479334 14562189 15365158 17346443 22843330	CTD
310	Hypercholesterolemia		8055207	CTD
311	Hyperplasia			SIDER
312	Hyperpyrexia			SIDER
313	Immune Complex Diseases		122655 159020	CTD
314	Incontinence			OFFSIDES
315	Inflammation		22945834	CTD
316	Infusion site mobility decreased			OFFSIDES
317	Isaacs syndrome		466063	CTD
318	JC virus infection			OFFSIDES
319	Jaundice, Obstructive		View details 436073 629612 3759835 3997313 4048879 6723128 7213433 8055207	CTD
320	Joint abscess			OFFSIDES
321	Kidney Diseases		View details 49668 97051 159020 950631 1080704 1677490 2939913 2941196 4175137	CTD
322	Lafora Disease		7445978	CTD
323	Lead Poisoning		125923 5953529 7370063	CTD
324	Leukocytosis			SIDER
325	Lichen Planus			SIDER
326	Lichenoid Eruptions		49598 17346443	CTD
327	Limb operation			OFFSIDES
328	Liver Cirrhosis		20946909	CTD
329	Liver diseases		21364284 24901380	CTD
330	Liver neoplasms		3972888	CTD
331	Low Back Pain		1833009	CTD
332	Lung Diseases, Interstitial		6637187 7043674	CTD
333	Lung Diseases, Obstructive		3083505	CTD
334	Lung diseases		View details 1094875 3576513 6945838 9989295	CTD
335	Lupus Erythematosus, Systemic		View details 159020 1604135 2082056 2940667 3752071 6216862 6658398 6723128 6939878 7213433 7370063 8592607	CTD
336	Lupus Erythematosus			SIDER
337	Lupus-like syndrome			SIDER
338	Lymphadenopathy			SIDER
339	Lymphocyte percentage decreased			OFFSIDES
340	Macrocytosis			OFFSIDES
341	Mental disorders		2334309	CTD
342	Mercury Poisoning		7370063	CTD
343	Mesothelioma		24013775	CTD
344	Monocytosis			SIDER
345	Muscle Weakness		View details 78009 122656 287196 717993 2025947 4853253 6830075 7420683 7452649 8929785	CTD
346	Musculoskeletal discomfort			SIDER
347	Myasthenia Gravis, Autoimmune, Experimental		6431900	CTD
348	Myoclonus		5421930	CTD
349	Myositis		View details 1895284 2952797 4548017 6782670 8929785	CTD
350	Nephritis, Interstitial		3823508	CTD
351	Nephritis	Canada Vigilance: 1	6939878	CTD Canada Vigilance
352	Neurologic Manifestations		7710368	CTD
353	Neuromuscular Diseases		6475118	CTD
354	Neuropathy			SIDER
355	Olfaction Disorders		2025947	CTD
356	Ophthalmoplegia		6305039 6481374 9093961	CTD
357	Optic Neuritis		1172464 5953529	CTD SIDER
358	Oral Ulcer		623127 2938530	CTD
359	Osteolysis			OFFSIDES
360	Pancreatitis		7445978	CTD SIDER
361	Papule			SIDER
362	Paraproteinemias		5645186	CTD
363	Paresis		2144538	CTD
364	Peptic Ulcer			SIDER
365	Peptic ulcer reactivated			SIDER
366	Peripheral Nervous System Diseases		5488219 6305039	CTD
367	Peritonitis			OFFSIDES
368	Pharyngolaryngeal Pain			OFFSIDES
369	Pneumocystis jiroveci pneumonia			OFFSIDES
370	Polyarteritis Nodosa		2399379	CTD
371	Polyarthralgia			SIDER
372	Polymyositis		View details 984614 1604135 1775410 2025947 2591396 3489699 3492802 3707633 4001884 4018948 4056558 4116745 4853253 6216862 6531742 6658398 6726729 7121648 7207503 7221458 7292078 7362693 7370063 7458422 8187449 8252325 8268147 10352832 12428861	CTD SIDER
373	Polyradiculopathy		2327244	CTD
374	Postoperative Complications		3768231 7425327	CTD
375	Primary Myelofibrosis		4587169	CTD
376	Prion Diseases		14519758	CTD
377	Protein urine present			SIDER
378	Protein-losing gastroenteropathy			OFFSIDES
379	Proteinuria	Canada Vigilance: 1	View details 48830 74171 122655 141075 144507 161403 294903 310574 518142 623127 626709 691197 950631 1005658 1189496 1195663 1221947 1617896 2082056 2334179 2782197 2917229 2938530 2939913 2947217 2952797 3083505 3132218 3437418 3459889 3487119 4119168 4169108 4216306 5071635 5241672 5641080 6151882 6174045 6216862 6218857 6376799 6420562 6441248 6451692 6723128 6782670 6857704 6864688 6939879 7206401 7342491 7362666 7432580 7452649 7944624 8592607 11149553	CTD SIDER Canada Vigilance
380	Pruritus		769707 8463474	CTD
381	Psychotic Disorders		7792379	CTD
382	Pulmonary Fibrosis		6531886	CTD SIDER
383	Pulmonary Infarction			OFFSIDES
384	Purulent discharge			OFFSIDES
385	Pyridoxine Deficiency			SIDER
386	Quadriparesis			OFFSIDES
387	Rash erythematous			SIDER
388	Red blood cell schistocytes present			OFFSIDES
389	Renal Insufficiency		View details 3430507 9426850 9551449 9989295 10644924 11149553	CTD
390	Renal tubular disorder			OFFSIDES
391	Renal vasculitis			SIDER
392	Respiratory Failure			OFFSIDES
393	Respiratory Insufficiency		7425327	CTD
394	Respiratory tract infection fungal			OFFSIDES
395	Retinal Diseases		736410	CTD
396	Retrocollis			OFFSIDES
397	Rhabdomyolysis		144507	CTD
398	Salmonella			OFFSIDES
399	Scleroderma renal crisis			OFFSIDES
400	Seizures		5421930	CTD
401	Signs and Symptoms, Digestive		144507 2938530	CTD
402	Skin Abnormalities		View details 1558988 3246093 4045909 8003796 9602696 16394408	CTD
403	Splenomegaly		21227906	CTD
404	Synovitis		290353 4014226	CTD SIDER
405	Taste Disorders		View details 144507 623127 685734 769707 2025947 3083505 4216306 4723471 5071635 5488219 6460054 7362666	CTD
406	Thalamic Diseases		9476721	CTD
407	Thrombocytosis			SIDER
408	Thrombophlebitis			SIDER
409	Thrombotic thrombocytopenic purpura, acquired		1168300	CTD
410	Thymoma		1212597	CTD
411	Thymus Hyperplasia		930944 6535556 7282112	CTD
412	Thyroiditis			SIDER
413	Tinnitus			OFFSIDES SIDER
414	Toxic Epidermal Necrolysis			SIDER
415	Trauma			SIDER
416	Ulcer			OFFSIDES
417	Uremia		760401	CTD
418	Urination Disorders		3977424	CTD
419	Vasculitis, Central Nervous System		9093961	CTD
420	Ventricular hypokinesia			OFFSIDES
421	Vision Disorders		1940953	CTD
422	Vitamin B 6 Deficiency		3341945 5421930	CTD
423	Weight Gain		7445978	CTD
424	Wrong drug administered			OFFSIDES
425	melanoma		22843330	CTD

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