MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

insulinoma

(UMLS:C0021670)

Definition:: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
UMLS ID:: C0021670
MeSH ID:: D007340

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.035.100.852|C04.588.274.761.249.500|C04.588.322.475.249.500

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.301.761.249.500|C06.689.667.249.500

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.344.421.249.500

Synonym(s)

insulinoma

Beta Cell Neoplasm

Beta Cell Neoplasm of Pancreas

Beta Cell Neoplasm of the Pancreas

Beta Cell Tumor

Beta Cell Tumor of Pancreas

Beta Cell Tumor of the Pancreas

Beta cell adenoma

Beta-cell adenoma

10.

INSULINOMA

11.

INSULOMA

12.

Insulin-Producing Islet Cell Neoplasm

13.

Insulin-Producing Islet Cell Tumor

14.

Insulin-Producing Neoplasm of Islet Cells

15.

Insulin-Producing Neoplasm of the Islet Cells

16.

Insulin-Producing Tumor of Islet Cells

17.

Insulin-Producing Tumor of the Islet Cells

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 7 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Sildenafil Citrate	FAERS: 3		US FAERS
3	Dabigatran	FAERS: 2		US FAERS
4	Everolimus	FAERS: 2		US FAERS
5	Metformin	FAERS: 2		US FAERS
6	Tamsulosin	FAERS: 2		US FAERS
7	Valsartan	FAERS: 2		US FAERS
8	Verapamil	FAERS: 2		US FAERS
9	candesartan	FAERS: 2		US FAERS
10	Alprazolam	FAERS: 1		US FAERS
11	Amlodipine	FAERS: 1		US FAERS
12	Carbamazepine	FAERS: 1		US FAERS
13	Cinacalcet	FAERS: 1		US FAERS
14	Hydrocortisone	FAERS: 1		US FAERS
15	Lenalidomide	FAERS: 1		US FAERS
16	Letrozole	FAERS: 1		US FAERS
17	Liraglutide	FAERS: 1		US FAERS
18	Mefloquine	FAERS: 1		US FAERS
19	Metformin	FAERS: 1		US FAERS
20	Mycophenolic Acid	FAERS: 1		US FAERS
21	Oxcarbazepine	FAERS: 1		US FAERS
22	Pregabalin	FAERS: 1		US FAERS
23	Rosuvastatin Calcium	FAERS: 1		US FAERS
24	Sitagliptin Phosphate	FAERS: 1		US FAERS
25	Sunitinib	FAERS: 1		US FAERS
26	Sunitinib	FAERS: 1		US FAERS
27	Telmisartan	FAERS: 1		US FAERS
28	Valproic Acid	FAERS: 1		US FAERS
29	glimepiride	FAERS: 1		US FAERS
30	Anastrozole			OFFSIDES
31	Capecitabine			OFFSIDES
32	Carbimazole			OFFSIDES
33	Pamidronate			OFFSIDES
34	Streptozocin		199092 6225653	CTD SIDER
35	Tamoxifen			OFFSIDES
36	Vinorelbine			OFFSIDES
37	exemestane			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Carcinoma, Pancreatic Ductal	35.2%
2	Peritoneal Neoplasms	24.7%
3	Gastrinoma	24.2%
4	Glucagonoma	24.2%
5	Vipoma	23.2%
6	Parathyroid Neoplasms	21.4%
7	Thyroid Neoplasm	21.4%
8	Thyroid carcinoma	21.4%
9	Gastrointestinal Neoplasms	21%
10	Liver neoplasms	21%
11	Multiple Endocrine Neoplasia	21%
12	Hepatocellular Adenoma	19.4%
13	Adrenal Gland Neoplasms	17.4%
14	Esophageal Neoplasms	17.1%
15	Prolactinoma	15.8%
16	Growth Hormone-Secreting Pituitary Adenoma	15.8%
17	Cystadenoma	15.6%
18	Mesothelioma	15.6%
19	Testicular Neoplasms	15.3%
20	Abdominal Neoplasms	14.6%
21	Head and Neck Neoplasms	14.6%
22	Soft Tissue Neoplasms	14.6%
23	Thoracic Neoplasms	14.6%
24	Liver Neoplasms, Experimental	14.2%
25	Pancreatic Cyst	13.8%
26	ovarian neoplasm	13.5%
27	Neoplasms, Neuroepithelial	13.4%
28	Gliomatosis cerebri	13.4%
29	Eye Neoplasms	13.2%
30	Nervous System Neoplasms	13.2%
31	Bile Duct Neoplasms	13.1%
32	gallbladder neoplasm	13.1%
33	Intestinal Neoplasms	13.1%
34	Stomach Neoplasms	13.1%
35	Bone neoplasms	12.9%
36	Skin Neoplasms	12.9%
37	Hematologic Neoplasms	12.9%
38	Carcinoma, Lobular	12.9%
39	Splenic Neoplasms	12.8%
40	Adenoma, Acidophil	12.6%
41	Thyroid Nodule	12.6%
42	Acanthoma	12.5%
43	Adenomatous Polyposis Coli	12.4%
44	Hamartoma	12.1%
45	Neoplasms, Hormone-Dependent	12.1%
46	Neoplasms, Multiple Primary	12.1%
47	Paraneoplastic Syndromes	12.1%
48	Precancerous Conditions	12.1%
49	Neoplasms, Second Primary	12.1%
50	Pituitary Adenoma	12%
51	Pituitary Neoplasms	12%
52	Multiple Endocrine Neoplasia Type 1	11.9%
53	Adenomatosis, Pulmonary	11.7%
54	Adenomatous Polyps	11.7%
55	Paraneoplastic Encephalomyelitis	11.3%
56	Digestive System Neoplasms	11.3%
57	Mammary Neoplasms, Experimental	11.2%
58	Zollinger-Ellison syndrome	11.1%
59	Carcinoma, Ovarian Epithelial	11%
60	Carcinoma, Ehrlich Tumor	11%
61	Carcinoma, Lewis Lung	11%
62	Pancreatic Fistula	10.9%
63	Basal cell carcinoma	10.8%
64	Carcinoma, Papillary	10.8%
65	Squamous cell carcinoma	10.8%
66	Carcinoma, Basal Cell	10.8%
67	Cyst	10.6%
68	Neoplastic Processes	10.6%
69	Neoplastic Syndromes, Hereditary	10.6%
70	Pregnancy Complications, Neoplastic	10.6%
71	Neoplasms, Experimental	10.6%
72	leukemia	10.4%
73	Neoplasms, Germ Cell and Embryonal	10.4%
74	Germ Cell Cancer	10.4%
75	Carcinoma	10.3%
76	Epithelioma	10.3%
77	Meningioma	10.3%
78	Neuroectodermal Tumors	10.1%
79	Choledochal Cyst	9.7%
80	Trophoblastic Neoplasms	9.4%
81	Neoplasms, Radiation-Induced	9.4%
82	Leukemia, Experimental	9.4%
83	granulosa cell tumor	9.4%
84	Colorectal Neoplasms	9.4%
85	Carcinoma 256, Walker	9.4%
86	Pancreatic Insufficiency	9.3%
87	Pancreatitis	9.3%
88	Tracheal Neoplasms	9.2%
89	Histiocytic Disorders, Malignant	9.2%
90	Gastrointestinal Stromal Tumors	9.2%
91	Pancreatic Neoplasm	9%
92	Cecal Neoplasms	9%
93	Duodenal Neoplasms	9%
94	Cystadenocarcinoma	9%
95	Mucoepidermoid Carcinoma	9%
96	Tuberous Sclerosis	9%
97	Medulloblastoma	8.7%
98	Adrenocortical carcinoma	8.7%
99	Leukemia, Radiation-Induced	8.5%
100	Dermoid Cyst	8.5%
101	Biliary Tract Diseases	8.5%
102	Gastrointestinal Diseases	8.5%
103	Liver diseases	8.5%
104	Retinoblastoma	8.5%
105	Melanoma, Experimental	8.4%
106	Ganglioneuroma	8.3%
107	Glioma	8.3%
108	Malignant Glioma	8.3%
109	Thymoma	8.3%
110	Lymphoma	8.2%
111	Composite Lymphoma	8.1%
112	Carcinosarcoma	8%
113	Hemangiosarcoma	8%
114	lymphangiosarcoma	8%
115	Retroperitoneal Neoplasms	8%
116	melanoma	8%
117	Barrett Esophagus	7.9%
118	Pancreatic Pseudocyst	7.9%
119	Choriocarcinoma	7.7%
120	Nephroblastoma	7.6%
121	Sarcoma, Experimental	7.6%
122	Endocrine Gland Neoplasms	7.5%
123	Basal Cell Nevus Syndrome	7.5%
124	Bowen's Disease	7.2%
125	Leukemia, Plasma Cell	7.2%
126	Mouth Neoplasms	7.1%
127	Central Nervous System Neoplasms	7.1%
128	Vascular Neoplasms	7.1%
129	Thymus Neoplasms	7.1%
130	Genital Neoplasms, Female	7.1%
131	Leydig Cell Tumor	7.1%
132	Breast Neoplasms, Male	7%
133	Triple Negative Breast Neoplasms	7%
134	Adenofibroma	6.9%
135	Fibroadenoma	6.9%
136	Carcinoid Tumor	6.7%
137	Appendiceal Neoplasms	6.7%
138	Colonic Neoplasms	6.7%
139	Rectal Neoplasms	6.7%
140	Cystic Fibrosis	6.7%
141	Congenital Hyperinsulinism	6.5%
142	Genital Neoplasms, Male	6.4%
143	Uveal Neoplasms	6.4%
144	Urologic Neoplasms	6.4%
145	Sebaceous Gland Neoplasms	6.3%
146	Spinal Neoplasms	6.3%
147	Bone Marrow Neoplasms	6.3%
148	Erythroplasia	6.3%
149	Follicular cyst	6.3%
150	Mucocele	6.3%
151	Pilonidal Cyst	6.3%
152	Thyroglossal Cyst	6.3%
153	Synovial Cyst	6.3%
154	Aberrant Crypt Foci	6.3%
155	Acoustic Neuroma	6.2%
156	Adenocarcinoma	6.2%
157	Carcinoma in Situ	6.2%
158	Carcinoma, Transitional Cell	6.2%
159	Papilloma	6.2%
160	Pseudomyxoma Peritonei	6.2%
161	Papillomatosis	6.2%
162	Carcinoma, Large Cell	6.2%
163	Carcinoma, Small Cell	6.2%
164	Nelson Syndrome	6.1%
165	Leukemia L1210	6%
166	Leukemia P388	6%
167	Chondrosarcoma	6%
168	Craniopharyngioma	6%
169	leiomyosarcoma	6%
170	liposarcoma	6%
171	synovial sarcoma	6%
172	Neuroectodermal Tumor, Melanotic	6%
173	Angiomyolipoma	6%
174	Clear Cell Sarcoma of Soft Tissue	6%
175	Alveolar Soft Part Sarcoma	6%
176	Neuroendocrine Tumors	6%
177	Sarcoma, Myeloid	6%
178	Lymphomatoid Granulomatosis	6%
179	Corpus Luteum Cyst	6%
180	Ovarian Cysts	6%
181	Anus Neoplasms	5.9%
182	Sigmoid Neoplasms	5.9%
183	Mesenteric vascular insufficiency	5.9%
184	Astrocytoma	5.8%
185	Ependymoma	5.8%
186	oligodendroglioma	5.8%
187	Ganglioglioma	5.8%
188	gliosarcoma	5.8%
189	Anaplastic astrocytoma	5.8%
190	Anaplastic Oligodendroglioma	5.8%
191	Leukoplakia, Oral	5.8%
192	Paraneoplastic Cerebellar Degeneration	5.8%
193	Esophageal Atresia	5.8%
194	Intestinal Atresia	5.8%
195	Mesenteric Vascular Occlusion	5.8%
196	Intestinal Fistula	5.8%
197	Enterocutaneous Fistula	5.8%
198	Ameloblastoma	5.7%
199	Angiokeratoma	5.7%
200	Chordoma	5.7%
201	Hemangioma	5.7%
202	hemangiopericytoma	5.7%
203	Lymphangioma	5.7%
204	Mesenchymoma	5.7%
205	Nevus	5.7%
206	Teratoma	5.7%
207	Hepatoblastoma	5.7%
208	Mixed Tumor, Mullerian	5.7%
209	Germinoma	5.7%
210	Teratocarcinoma	5.7%
211	Angiofibroma	5.7%
212	Optic Nerve Glioma	5.7%
213	Sarcoma	5.7%
214	Peutz-Jeghers Syndrome	5.7%
215	Endometrial Stromal Sarcoma	5.6%
216	Leukoplakia	5.5%
217	Lymphocele	5.5%
218	Pancreatitis, Chronic	5.5%
219	Breast Cyst	5.5%
220	Actinic keratosis	5.5%
221	Mediastinal Cyst	5.5%
222	Neoplasm Invasiveness	5.5%
223	Neoplasm Metastasis	5.5%
224	Neoplasm Recurrence, Local	5.5%
225	Parovarian Cyst	5.5%
226	Pericardial Cyst	5.5%
227	Thymic Cyst	5.5%
228	Carcinogenesis	5.5%
229	Myxoid cyst	5.5%
230	Metastasis	5.5%
231	Biliary cirrhosis	5.4%
232	Nose Neoplasms	5.4%
233	Neurilemmoma	5.3%
234	Hutchinson's Melanotic Freckle	5.3%
235	Melanoma, Amelanotic	5.3%
236	Limbic Encephalitis	5.3%
237	Mesoblastic Nephroma	5.2%
238	Plasmacytoma	5.1%
239	Malignant Carcinoid Syndrome	5%
240	Malignant histiocytosis	5%
241	Histiocytic sarcoma	5%
242	Sarcoma 180	5%
243	Fibrosarcoma	5%
244	Osteosarcoma	5%
245	Proctocolitis	4.9%
246	Lambert-Eaton Myasthenic Syndrome	4.9%
247	Dysentery	4.8%
248	Enteritis	4.8%
249	Enterocolitis	4.8%
250	Esophageal and Gastric Varices	4.8%
251	Esophagitis	4.8%
252	Gastritis	4.8%
253	Inflammatory Bowel Diseases	4.8%
254	Cholecystolithiasis	4.8%
255	Pancreatitis, Alcoholic	4.8%
256	Lymphangioleiomyomatosis	4.8%
257	Palatal Neoplasms	4.7%
258	Bile Duct Diseases	4.6%
259	Cholelithiasis	4.6%
260	Chylous Ascites	4.6%
261	Esophageal Diseases	4.6%
262	Fatty Liver	4.6%
263	Gastroenteritis	4.6%
264	Hepatitis	4.6%
265	Portal Hypertension	4.6%
266	Intestinal Diseases	4.6%
267	Liver Cirrhosis	4.6%
268	Pneumoperitoneum	4.6%
269	Stomach Diseases	4.6%
270	Focal Nodular Hyperplasia	4.6%
271	Hepatic Insufficiency	4.6%
272	Steatohepatitis	4.6%
273	Nasopharyngeal carcinoma	4.6%
274	Glioblastoma	4.6%
275	Neuroblastoma	4.6%
276	Glioblastoma Multiforme	4.6%
277	Opsoclonus-Myoclonus Syndrome	4.5%
278	Rectal Fistula	4.5%
279	Anal Fistula	4.5%
280	Malignant Fibrous Histiocytoma	4.5%
281	Hodgkin Disease	4.5%
282	Lymphoma, Non-Hodgkin	4.5%
283	Carcinoma, Endometrioid	4.3%
284	Fatty Liver, Alcoholic	4.3%
285	Hepatitis, Alcoholic	4.3%
286	Liver Cirrhosis, Alcoholic	4.3%
287	Duodenitis	4.3%
288	Ileitis	4.3%
289	Erosive Duodenitis	4.3%
290	Renal Cell Carcinoma	4.3%
291	Papillary Renal Cell Carcinoma	4.3%
292	Adrenal Gland Diseases	4.3%
293	Gonadal Disorders	4.3%
294	Pancreatic Diseases	4.3%
295	Parathyroid Diseases	4.3%
296	Thyroid Diseases	4.3%
297	Meningeal Neoplasms	4.2%
298	Neoplasms, Glandular and Epithelial	4.2%
299	Liver Diseases, Parasitic	4.2%
300	Myelitis, Transverse	4.2%
301	Adenoid Cystic Carcinoma	4.1%
302	Adenocarcinoma, Clear Cell	4.1%
303	Cholangiocarcinoma	4.1%
304	Cervical Intraepithelial Neoplasia	4.1%
305	Hepatic Veno-Occlusive Disease	4.1%
306	Peliosis Hepatis	4.1%
307	Hepatopulmonary Syndrome	4.1%
308	Anus, Imperforate	4.1%
309	Gastrointestinal Hemorrhage	4.1%
310	Hemoperitoneum	4.1%
311	Hepatomegaly	4.1%
312	Mesenteric Panniculitis	4.1%
313	Panniculitis, Peritoneal	4.1%
314	Peritonitis	4.1%
315	Peritoneal Fibrosis	4.1%
316	Encapsulating Peritoneal Sclerosis	4.1%
317	Anorectal Malformations	4.1%
318	Biliary Fistula	4.1%
319	Gastric Fistula	4.1%
320	Primary amyloidosis	4.1%
321	Hepatic Vein Thrombosis	4%
322	Liver Abscess	4%
323	Budd-Chiari Syndrome	4%
324	Tuberculosis, Gastrointestinal	4%
325	Colitis	4%
326	Duodenogastric Reflux	4%
327	Peptic Ulcer	4%
328	Proctitis	4%
329	Choledocholithiasis	4%
330	Paraganglioma	4%
331	Rhabdomyosarcoma	4%
332	Giant Cell Tumor of Bone	4%
333	Neurofibrosarcoma	4%
334	Ganglioneuroblastoma	4%
335	Denys-Drash Syndrome	4%
336	Nesidioblastosis	3.9%
337	Ear Neoplasms	3.8%
338	Eyelid Neoplasms	3.8%
339	Lung Neoplasms	3.8%
340	Pleural Neoplasms	3.8%
341	Carcinoid Heart Disease	3.8%
342	Brain Neoplasms	3.8%
343	Salivary Gland Neoplasms	3.8%
344	Spinal Cord Neoplasms	3.8%
345	Tongue Neoplasms	3.8%
346	Bone Diseases, Endocrine	3.8%
347	Uterine Neoplasms	3.7%
348	Vaginal Neoplasms	3.7%
349	Vulvar Neoplasms	3.7%
350	Uterine Cancer	3.7%
351	Fallopian Tube Neoplasms	3.7%
352	insulinoma	3.7%
353	Diabetes Mellitus	3.7%
354	Pituitary Diseases	3.7%
355	Chemical and Drug Induced Liver Injury	3.7%
356	Hepatorenal Syndrome	3.6%
357	Appendicitis	3.6%
358	Liver Abscess, Amebic	3.6%
359	Dermatofibrosarcoma	3.5%
360	Dermatofibrosarcoma Protuberans	3.5%
361	Pharyngeal Neoplasms	3.5%
362	Phyllodes Tumor	3.4%
363	Dysgerminoma	3.4%
364	Hemangioendothelioma	3.4%
365	Lipoma	3.4%
366	Myoma	3.4%
367	Myxoma	3.4%
368	Neuroma	3.4%
369	Seminoma	3.4%
370	Angiolipoma	3.4%
371	Myelolipoma	3.4%
372	Neoplasms, Bone Tissue	3.4%
373	Neoplasms, Fibrous Tissue	3.4%
374	Smooth Muscle Tumor	3.4%
375	Desmoplastic Small Round Cell Tumor	3.4%
376	Chondroma	3.4%
377	Enchondroma	3.4%
378	Central Nervous System Cysts	3.4%
379	Penile Neoplasms	3.4%
380	Prostatic Neoplasms	3.4%
381	Polycystic Ovary Syndrome	3.4%
382	Waldenstrom Macroglobulinemia	3.4%
383	Multiple Myeloma	3.4%
384	Hydatidiform Mole	3.4%
385	Polycythemia Vera	3.4%
386	Dwarfism	3.3%
387	Porphyrias, Hepatic	3.3%
388	Crohn Disease	3.2%
389	Duodenal Obstruction	3.2%
390	Enterocolitis, Neutropenic	3.2%
391	Necrotizing Enterocolitis	3.2%
392	Pouchitis	3.2%
393	Laryngeal neoplasm	3.2%
394	Xeroderma Pigmentosum	3.2%
395	Bladder Neoplasm	3.1%
396	Kidney Neoplasm	3.1%
397	Ureteral Neoplasms	3.1%
398	Urethral Neoplasms	3.1%
399	Klatskin Tumor	3.1%
400	Lymphatic Metastasis	3%
401	Neoplasms, Unknown Primary	3%
402	Leukemic Infiltration	3%
403	Neoplasm Micrometastasis	3%
404	Leukemia, Myelomonocytic, Chronic	3%
405	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3%
406	Pheochromocytoma	3%
407	Alveolar rhabdomyosarcoma	3%
408	Enterocolitis, Pseudomembranous	2.9%
409	pseudomembranous colitis	2.9%
410	Dysentery, Bacillary	2.9%
411	Duodenal Ulcer	2.8%
412	Peptic Ulcer Perforation	2.8%
413	Gastric ulcer	2.8%
414	Meningeal Carcinomatosis	2.8%
415	Cecal Diseases	2.8%
416	Cholangitis	2.8%
417	Cholecystitis	2.8%
418	Cholestasis	2.8%
419	Colonic Diseases	2.8%
420	Common Bile Duct Diseases	2.8%
421	Esophageal Stenosis	2.8%
422	Hepatitis, Chronic	2.8%
423	Ileal Diseases	2.8%
424	Intestinal Obstruction	2.8%
425	Intestinal Perforation	2.8%
426	Jejunal Diseases	2.8%
427	Pneumatosis Cystoides Intestinalis	2.8%
428	Rectal Diseases	2.8%
429	Gastric Dilatation	2.8%
430	Liver Failure	2.8%
431	Gastric outlet obstruction	2.8%
432	Cronkhite-Canada Syndrome	2.8%
433	Non-alcoholic Fatty Liver Disease	2.8%
434	Chronic active hepatitis	2.8%
435	Intestinal Polyposis	2.8%
436	Mastocytosis	2.7%
437	Sturge-Weber Syndrome	2.7%
438	Hemangioma, Cavernous	2.7%
439	Leukemia, T-Cell	2.7%
440	Leukemia, B-Cell	2.7%
441	neurofibroma	2.7%
442	Lymphoma, Follicular	2.7%
443	T-Cell Lymphoma	2.7%
444	Mantle cell lymphoma	2.7%
445	Bronchial Neoplasms	2.5%
446	Colitis, Ischemic	2.5%
447	Multiple Pulmonary Nodules	2.5%
448	Supratentorial Neoplasms	2.5%
449	Esophageal Perforation	2.5%
450	Hepatitis, Animal	2.5%
451	Hepatitis, Viral, Human	2.5%
452	Intestinal Diseases, Parasitic	2.5%
453	Endometrial Neoplasms	2.5%
454	Deglutition Disorders	2.4%
455	Achlorhydria	2.4%
456	Liver Cirrhosis, Experimental	2.4%
457	Gastric Antral Vascular Ectasia	2.4%
458	Peptic Ulcer Hemorrhage	2.4%
459	Gastroparesis	2.4%
460	Congenital Hypothyroidism	2.4%
461	Adrenal Cortex Diseases	2.3%
462	Euthyroid Sick Syndromes	2.3%
463	Goiter	2.3%
464	Hyperparathyroidism	2.3%
465	Hyperthyroidism	2.3%
466	Hyperthyroxinemia	2.3%
467	Hypogonadism	2.3%
468	Hypoparathyroidism	2.3%
469	Hypothyroidism	2.3%
470	Delayed Puberty	2.3%
471	Precocious Puberty	2.3%
472	Thyroiditis	2.3%
473	Hypogonadotropic hypogonadism	2.3%
474	Testotoxicosis	2.3%
475	Secondary hypothyroidism	2.3%
476	Primary Hyperthyroidism	2.3%
477	Primary Hypothyroidism	2.3%
478	Adenoma	2.3%
479	fibroma	2.3%
480	Fibromatosis	2.3%
481	Osteoblastoma	2.3%
482	Osteoma	2.3%
483	Rhabdomyoma	2.3%
484	Chondromatosis	2.3%
485	Hemangioblastoma	2.3%
486	Lymphoma, Extranodal NK-T-Cell	2.3%
487	Hypopharyngeal Neoplasms	2.3%
488	Pleural Effusion, Malignant	2.3%
489	Hypopharyngeal Cancer	2.3%
490	Hepatitis B, Chronic	2.3%
491	Hepatitis C, Chronic	2.3%
492	Parotid Neoplasms	2.2%
493	Prostatic Neoplasms, Castration-Resistant	2.2%
494	Colonic Pseudo-Obstruction	2.2%
495	Fascioliasis	2.2%
496	Echinococcosis, Hepatic	2.2%
497	Melena	2.2%
498	Chemical and Drug Induced Liver Injury, Chronic	2.2%
499	Reye Syndrome	2.2%
500	Hematemesis	2.1%
501	Testicular Diseases	2.1%
502	Ovarian Diseases	2%
503	Zellweger Syndrome	2%
504	Empty Sella Syndrome	2%
505	Hyperpituitarism	2%
506	Hypopituitarism	2%
507	Hypophysitis	2%
508	Mastocytoma	2%
509	Mastocytosis, Systemic	2%
510	Leukemia, Myeloid, Chronic-Phase	2%
511	Graves Disease	2%
512	Variegate Porphyria	1.9%
513	Acute intermittent porphyria	1.9%
514	Porphyria Cutanea Tarda	1.9%
515	Hepatolenticular Degeneration	1.9%
516	Nasopharyngeal Neoplasms	1.9%
517	Brain Stem Neoplasms	1.9%
518	Cholestasis, Extrahepatic	1.8%
519	Biliary Dyskinesia	1.8%
520	Cholangitis, Sclerosing	1.8%
521	Colonic Diseases, Functional	1.8%
522	Esophageal motility disorders	1.8%
523	Fecal Incontinence	1.8%
524	Fecal Impaction	1.8%
525	Intussusception	1.8%
526	Mallory-Weiss Syndrome	1.8%
527	Megacolon	1.8%
528	Pyloric Stenosis	1.8%
529	Liver Failure, Acute	1.8%
530	Acalculous Cholecystitis	1.8%
531	End Stage Liver Disease	1.8%
532	Ileus	1.8%
533	Meconium ileus	1.8%
534	Gestational Diabetes	1.8%
535	Latent Autoimmune Diabetes in Adults	1.8%
536	Diabetes Insipidus	1.8%
537	Diabetes Mellitus, Experimental	1.8%
538	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
539	Leukemia, Large Granular Lymphocytic	1.8%
540	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
541	Lymphoma, T-Cell, Cutaneous	1.8%
542	Lymphoma, AIDS-Related	1.8%
543	Enteropathy-Associated T-Cell Lymphoma	1.8%
544	Primary Effusion Lymphoma	1.8%
545	Paranasal Sinus Neoplasms	1.8%
546	Fibromatosis, Aggressive	1.7%
547	Fibromatosis, Abdominal	1.7%
548	Tonsillar Neoplasms	1.7%
549	Cerebellar Neoplasms	1.7%
550	Hermaphroditism	1.6%
551	Disorders of Sex Development	1.6%
552	Hemorrhoids	1.6%
553	Autoimmune hepatitis	1.6%
554	Cell Transformation, Viral	1.6%
555	Pituitary Apoplexy	1.6%
556	Afferent Loop Syndrome	1.6%
557	Celiac Disease	1.6%
558	Short Bowel Syndrome	1.6%
559	Sprue, Tropical	1.6%
560	Steatorrhea	1.6%
561	Rectocele	1.6%
562	Sprue	1.6%
563	Diverticulitis	1.6%
564	Dumping Syndrome	1.6%
565	Rectal Prolapse	1.6%
566	Choroid Plexus Papilloma	1.5%
567	Hepatitis, Viral, Animal	1.5%
568	Giardiasis	1.5%
569	Hepatitis E	1.5%
570	Burkitt Lymphoma	1.5%
571	Hepatitis B	1.4%
572	Hepatitis C	1.4%
573	Diverticulum	1.4%
574	Hepatitis A	1.4%
575	Diverticulosis	1.4%
576	Hepatic Encephalopathy	1.4%
577	Cushing Syndrome	1.4%
578	Hyperaldosteronism	1.4%
579	Hyperparathyroidism, Secondary	1.4%
580	Hypoaldosteronism	1.4%
581	Thyrotoxicosis	1.4%
582	Hyperparathyroidism, Primary	1.4%
583	Thyroid Hormone Resistance Syndrome	1.4%
584	Massive Hepatic Necrosis	1.4%
585	Esophageal Achalasia	1.4%
586	Anal Fissure	1.4%
587	Intestinal Pseudo-Obstruction	1.4%
588	Irritable Bowel Syndrome	1.4%
589	Superior Mesenteric Artery Syndrome	1.4%
590	Emphysematous Cholecystitis	1.4%
591	Neurogenic Bowel	1.4%
592	Sphincter of Oddi Dysfunction	1.4%
593	Anal Ulcer	1.4%
594	Dupuytren Contracture	1.4%
595	Kallmann Syndrome	1.3%
596	Urticaria Pigmentosa	1.3%
597	Mycosis Fungoides	1.3%
598	Lymphomatoid Papulosis	1.3%
599	Plasmablastic lymphoma	1.3%
600	Maxillary Sinus Neoplasms	1.3%
601	Lactose Intolerance	1.3%
602	Diabetic Foot	1.3%
603	Klinefelter Syndrome	1.2%
604	Addison Disease	1.2%
605	Diabetic Angiopathies	1.2%
606	Autoimmune thyroiditis	1.2%
607	Primary Adrenal Insufficiency	1.2%
608	Diabetic Neuropathies	1.2%
609	Myxedema	1.2%
610	Orchitis	1.2%
611	Diabetic Amyotrophy	1.2%
612	Diabetic Autonomic Neuropathy	1.2%
613	Diabetic Cardiomyopathies	1.2%
614	Pruritus Ani	1.2%
615	Ovarian Hyperstimulation Syndrome	1.2%
616	Hyperprolactinemia	1.2%
617	Sezary Syndrome	1.1%
618	Cryptosporidiosis	1.1%
619	Gigantism	1.1%
620	Diabetic Nephropathy	1.1%
621	Acromegaly	1.1%
622	Anovulation	1.1%
623	Diabetic Ketoacidosis	1.1%
624	Oophoritis	1.1%
625	Laryngopharyngeal Reflux	1%
626	Cryptorchidism	1%
627	Gonadal Dysgenesis	1%
628	Adrenogenital Syndrome	1%
629	Ovotesticular Disorders of Sex Development	1%
630	Hyperglycemic Hyperosmolar Nonketotic Coma	0.9%
631	Hashimoto Disease	0.9%
632	Hyperandrogenism	0.9%
633	Rift Valley Fever	0.8%
634	CREST Syndrome	0.8%
635	Diabetic Retinopathy	0.7%
636	Turner Syndrome	0.7%
637	Radicular Cyst	0.7%
638	Waterhouse-Friderichsen Syndrome	0.6%
639	Renal Osteodystrophy	0.5%
640	Renal rickets	0.5%
641	Adrenoleukodystrophy	0.4%

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