MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Duodenal Obstruction

(UMLS:C0013292)

Definition:: Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.
UMLS ID:: C0013292
MeSH ID:: D004380

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.275.395|C06.405.469.531.311

Synonym(s)

Duodenal Obstruction

Duodenal obstruction

Obstruction of duodenum

duodenal obstruction

duodenum obstruction

duodenum; obstruction

obstruction duodenal

obstruction; duodenum

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ibuprofen	FAERS: 8	US FAERS
2	Isotretinoin	FAERS: 8	US FAERS
3	Arthrotec	FAERS: 4	US FAERS
4	Capecitabine	FAERS: 4	OFFSIDES US FAERS
5	Sitagliptin Phosphate	FAERS: 4	US FAERS
6	Epinephrine	FAERS: 3	US FAERS
7	Morphine	FAERS: 3	US FAERS
8	carbidopa, levodopa drug combination	FAERS: 3	US FAERS
9	Aspirin	FAERS: 2	US FAERS
10	Erlotinib Hydrochloride	FAERS: 2	OFFSIDES US FAERS
11	Imatinib Mesylate	FAERS: 2	US FAERS
12	Teriparatide	FAERS: 2	US FAERS
13	Warfarin	FAERS: 2	US FAERS
14	Afatinib	FAERS: 1	US FAERS
15	Diclofenac	FAERS: 1	US FAERS
16	Everolimus	FAERS: 1	US FAERS
17	Lenalidomide	FAERS: 1	US FAERS
18	Loratadine	FAERS: 1	US FAERS
19	Paroxetine	FAERS: 1	US FAERS
20	Sirolimus	FAERS: 1	US FAERS
21	Sorafenib	FAERS: 1	US FAERS
22	Valproic Acid	FAERS: 1	US FAERS
23	Valproic Acid	FAERS: 1	US FAERS
24	edoxaban	FAERS: 1	US FAERS
25	niraparib	FAERS: 1	US FAERS
26	pazopanib	FAERS: 1	US FAERS
27	Beclomethasone		OFFSIDES
28	Colestipol		OFFSIDES
29	Dextropropoxyphene		OFFSIDES
30	Didanosine		OFFSIDES
31	Diphenoxylate		OFFSIDES
32	Goserelin		OFFSIDES
33	Ketoconazole		OFFSIDES
34	Nateglinide		OFFSIDES
35	Nevirapine		OFFSIDES
36	Nortriptyline		OFFSIDES
37	Penicillins		OFFSIDES
38	Ribavirin		OFFSIDES
39	Sertraline		OFFSIDES
40	Thalidomide		OFFSIDES
41	Trimebutine		OFFSIDES
42	Zidovudine		OFFSIDES
43	Zoledronic Acid		OFFSIDES
44	bicalutamide		OFFSIDES
45	salicylsalicylic acid		OFFSIDES
46	samarium Sm-153 lexidronam		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Duodenitis	54.2%
2	Erosive Duodenitis	54.2%
3	Duodenogastric Reflux	50.4%
4	Peptic Ulcer	50.4%
5	Dysentery	49.2%
6	Enteritis	49.2%
7	Enterocolitis	49.2%
8	Inflammatory Bowel Diseases	49.2%
9	Fecal Impaction	47.3%
10	Intussusception	47.3%
11	Ileus	47.3%
12	Meconium ileus	47.3%
13	Zollinger-Ellison syndrome	47%
14	Cecal Diseases	45.7%
15	Colonic Diseases	45.7%
16	Ileal Diseases	45.7%
17	Intestinal Perforation	45.7%
18	Jejunal Diseases	45.7%
19	Pneumatosis Cystoides Intestinalis	45.7%
20	Rectal Diseases	45.7%
21	Cronkhite-Canada Syndrome	45.7%
22	Intestinal Polyposis	45.7%
23	Ileitis	43.9%
24	Duodenal Neoplasms	40.5%
25	Colorectal Neoplasms	40.2%
26	Proctocolitis	39.8%
27	Colonic Pseudo-Obstruction	38.7%
28	Colitis	37.4%
29	Proctitis	37.4%
30	Intestinal Diseases, Parasitic	36.2%
31	Duodenal Ulcer	36.1%
32	Peptic Ulcer Perforation	36.1%
33	Gastric ulcer	36.1%
34	Intestinal Neoplasms	36.1%
35	Afferent Loop Syndrome	35.8%
36	Intestinal Pseudo-Obstruction	35.3%
37	Mesenteric vascular insufficiency	35.1%
38	Intestinal Atresia	34.7%
39	Mesenteric Vascular Occlusion	34.7%
40	Intestinal Fistula	34.4%
41	Enterocutaneous Fistula	34.4%
42	Rectal Fistula	33.4%
43	Anal Fistula	33.4%
44	Esophageal Diseases	33.3%
45	Gastroenteritis	33.3%
46	Stomach Diseases	33.3%
47	Cecal Neoplasms	33.1%
48	Pouchitis	32.6%
49	Crohn Disease	32.3%
50	Enterocolitis, Neutropenic	32.3%
51	Necrotizing Enterocolitis	32.3%
52	Colonic Diseases, Functional	30.1%
53	Fecal Incontinence	30.1%
54	Megacolon	30.1%
55	Appendicitis	30.1%
56	Esophagitis	29.5%
57	Gastritis	29.5%
58	Gastrointestinal Neoplasms	27%
59	Anus Neoplasms	26.2%
60	Sigmoid Neoplasms	26.2%
61	Enterocolitis, Pseudomembranous	25.8%
62	pseudomembranous colitis	25.8%
63	Dysentery, Bacillary	25.8%
64	Gastrointestinal Hemorrhage	25%
65	Tuberculosis, Gastrointestinal	24.6%
66	Appendiceal Neoplasms	24.6%
67	Colonic Neoplasms	24.6%
68	Rectal Neoplasms	24.6%
69	Adenomatous Polyposis Coli	24.1%
70	Hemorrhoids	23.1%
71	Stomach Neoplasms	23%
72	Intestinal Obstruction	22.8%
73	Celiac Disease	22.8%
74	Short Bowel Syndrome	22.8%
75	Sprue, Tropical	22.8%
76	Steatorrhea	22.8%
77	Rectocele	22.8%
78	Sprue	22.8%
79	Duodenal Obstruction	22.6%
80	Rectal Prolapse	22.6%
81	Anal Fissure	22.5%
82	Irritable Bowel Syndrome	22.5%
83	Neurogenic Bowel	22.5%
84	Anal Ulcer	22.5%
85	Colitis, Ischemic	21.6%
86	Biliary Tract Diseases	20.9%
87	Liver diseases	20.9%
88	Pancreatic Diseases	20.9%
89	Esophageal Neoplasms	19.7%
90	Esophageal and Gastric Varices	19.7%
91	Esophageal Stenosis	19.6%
92	Gastric Dilatation	19.6%
93	Gastric outlet obstruction	19.6%
94	Giardiasis	18.8%
95	Esophageal Atresia	18.7%
96	Pruritus Ani	17%
97	Digestive System Neoplasms	15.8%
98	Gastrointestinal Stromal Tumors	15.7%
99	Esophageal Perforation	15.5%
100	Peutz-Jeghers Syndrome	15.3%
101	Lactose Intolerance	15.1%
102	Barrett Esophagus	15%
103	Deglutition Disorders	15%
104	Achlorhydria	14.8%
105	Gastric Antral Vascular Ectasia	14.8%
106	Peptic Ulcer Hemorrhage	14.6%
107	Gastroparesis	14.6%
108	Liver neoplasms	13.5%
109	Pancreatic Fistula	13.4%
110	Esophageal motility disorders	12.9%
111	Mallory-Weiss Syndrome	12.9%
112	Pyloric Stenosis	12.9%
113	Melena	11.9%
114	Hematemesis	11.7%
115	Cryptosporidiosis	11.6%
116	Peritoneal Neoplasms	11.2%
117	Superior Mesenteric Artery Syndrome	11.2%
118	Bile Duct Diseases	11.1%
119	Cholelithiasis	11.1%
120	Chylous Ascites	11.1%
121	Fatty Liver	11.1%
122	Hepatitis	11.1%
123	Portal Hypertension	11.1%
124	Liver Cirrhosis	11.1%
125	Pancreatic Insufficiency	11.1%
126	Pancreatitis	11.1%
127	Pneumoperitoneum	11.1%
128	Focal Nodular Hyperplasia	11.1%
129	Hepatic Insufficiency	11.1%
130	Steatohepatitis	11.1%
131	Bile Duct Neoplasms	9.8%
132	gallbladder neoplasm	9.8%
133	Cholecystolithiasis	9.8%
134	Biliary cirrhosis	9.8%
135	Pancreatic Neoplasm	9.7%
136	Diverticulitis	9.7%
137	Dumping Syndrome	9.7%
138	Esophageal Achalasia	9.6%
139	Choledochal Cyst	9%
140	Liver Diseases, Parasitic	8.8%
141	Hepatic Veno-Occlusive Disease	8.5%
142	Pancreatic Cyst	8.5%
143	Peliosis Hepatis	8.5%
144	Hepatopulmonary Syndrome	8.5%
145	Anus, Imperforate	8.3%
146	Hemoperitoneum	8.3%
147	Hepatomegaly	8.3%
148	Mesenteric Panniculitis	8.3%
149	Panniculitis, Peritoneal	8.3%
150	Peritonitis	8.3%
151	Peritoneal Fibrosis	8.3%
152	Encapsulating Peritoneal Sclerosis	8.3%
153	Anorectal Malformations	8.3%
154	Biliary Fistula	8.3%
155	Gastric Fistula	8.3%
156	Hepatic Vein Thrombosis	8.2%
157	Liver Abscess	8.2%
158	Budd-Chiari Syndrome	8.2%
159	Choledocholithiasis	8.1%
160	Diverticulum	7.9%
161	Diverticulosis	7.9%
162	Fatty Liver, Alcoholic	7.8%
163	Hepatitis, Alcoholic	7.8%
164	Liver Cirrhosis, Alcoholic	7.8%
165	Chemical and Drug Induced Liver Injury	6.8%
166	Hepatorenal Syndrome	6.6%
167	Cholangitis	6.5%
168	Cholecystitis	6.5%
169	Cholestasis	6.5%
170	Common Bile Duct Diseases	6.5%
171	Hepatitis, Chronic	6.5%
172	Liver Failure	6.5%
173	Pancreatitis, Chronic	6.5%
174	Hepatocellular Adenoma	6.5%
175	Non-alcoholic Fatty Liver Disease	6.5%
176	Chronic active hepatitis	6.5%
177	Laryngopharyngeal Reflux	6.2%
178	Cystic Fibrosis	5.7%
179	Liver Abscess, Amebic	5.7%
180	Liver Neoplasms, Experimental	5.7%
181	Porphyrias, Hepatic	5.6%
182	Congenital Hyperinsulinism	5.6%
183	Hepatitis, Animal	5.2%
184	Hepatitis, Viral, Human	5.2%
185	Liver Cirrhosis, Experimental	4.9%
186	Pancreatic Pseudocyst	4.9%
187	Pancreatitis, Alcoholic	4.9%
188	Carcinoma, Pancreatic Ductal	4.3%
189	Cholestasis, Extrahepatic	4.3%
190	Biliary Dyskinesia	4.3%
191	Cholangitis, Sclerosing	4.3%
192	Liver Failure, Acute	4.3%
193	Acalculous Cholecystitis	4.3%
194	End Stage Liver Disease	4.3%
195	Fascioliasis	4%
196	Echinococcosis, Hepatic	4%
197	Chemical and Drug Induced Liver Injury, Chronic	3.9%
198	Reye Syndrome	3.9%
199	Hepatitis B, Chronic	3.8%
200	Hepatitis C, Chronic	3.8%
201	CREST Syndrome	3.6%
202	Autoimmune hepatitis	3.3%
203	Nesidioblastosis	3.2%
204	Variegate Porphyria	3.2%
205	Acute intermittent porphyria	3.2%
206	Porphyria Cutanea Tarda	3.2%
207	Massive Hepatic Necrosis	3.2%
208	Emphysematous Cholecystitis	3.2%
209	Sphincter of Oddi Dysfunction	3.2%
210	insulinoma	3.2%
211	Gastrinoma	3.2%
212	Glucagonoma	3.2%
213	Vipoma	2.8%
214	Hepatitis, Viral, Animal	2.8%
215	Zellweger Syndrome	2.7%
216	Hepatitis E	2.7%
217	Hepatitis B	2.6%
218	Hepatitis C	2.6%
219	Hepatitis A	2.6%
220	Hepatic Encephalopathy	2.6%
221	Hepatolenticular Degeneration	2.5%
222	Rift Valley Fever	1.3%

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