MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Peptic Ulcer Perforation

(UMLS:C0030925)

Definition:: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.
UMLS ID:: C0030925
MeSH ID:: D010439

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.275.800.698|C06.405.748.586.698

Synonym(s)

Peptic Ulcer Perforation

PEPTIC ULCER PERFORATED

PEPTIC ULCER WITH PENETRATION

PERFORATED PEPTIC ULCER

Peptic ulcer perforation

Peptic ulcer with perforation

Peptic ulcer, NOS with perforation

Perforated Peptic Ulcer

Perforated peptic ulcer

10.

peptic perforated ulcer

11.

peptic perforated ulcers

12.

peptic perforation ulcer

13.

peptic ulcer perforation

14.

peptic; ulcer, with perforation

15.

perforate peptic ulcer

16.

perforated peptic ulcer

17.

perforation peptic ulcer

18.

ulcer peptic perforation

19.

ulcer; peptic, with perforation

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ibuprofen	FAERS: 9 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Aspirin	FAERS: 2		US FAERS
3	Clozapine	FAERS: 2		US FAERS
4	Dexamethasone	FAERS: 2		US FAERS
5	Dimethyl Fumarate	FAERS: 2		US FAERS
6	Diphenhydramine	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
7	Imatinib Mesylate	FAERS: 2		US FAERS
8	Prednisolone	FAERS: 2		US FAERS
9	rofecoxib	FAERS: 2		US FAERS
10	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
11	Afatinib	FAERS: 1		US FAERS
12	Celecoxib	FAERS: 1		US FAERS
13	Cilostazol	FAERS: 1		US FAERS
14	Clopidogrel	FAERS: 1		US FAERS
15	Dabigatran	FAERS: 1		US FAERS
16	Fluoxetine	FAERS: 1		US FAERS
17	Lenalidomide	FAERS: 1		US FAERS
18	Naproxen	FAERS: 1		US FAERS
19	Olanzapine	FAERS: 1		US FAERS
20	Omeprazole	FAERS: 1		US FAERS
21	PCI 32765	FAERS: 1		US FAERS
22	Risperidone	FAERS: 1		US FAERS
23	Rivaroxaban	FAERS: 1		US FAERS
24	Zoledronic Acid	FAERS: 1		US FAERS
25	acetaminophen, aspirin, caffeine drug combination	FAERS: 1		US FAERS
26	aliskiren	FAERS: 1		OFFSIDES US FAERS
27	Bisacodyl			OFFSIDES
28	Cimetidine		6123873	CTD
29	Cocaine		17701263 20013613	CTD
30	Danazol	Canada Vigilance: 1		Canada Vigilance
31	Diclofenac	Canada Vigilance: 1		Canada Vigilance
32	Mercaptopurine	Canada Vigilance: 1		Canada Vigilance
33	Mesalamine			SIDER
34	Methylprednisolone Acetate			OFFSIDES
35	Mycophenolic Acid			OFFSIDES SIDER
36	Nateglinide			OFFSIDES
37	Phenelzine			OFFSIDES
38	Piroxicam			OFFSIDES
39	Potassium Acetate			OFFSIDES
40	Prednisone	Canada Vigilance: 1		Canada Vigilance
41	Sterazolidin	Canada Vigilance: 1		Canada Vigilance
42	Thalidomide			OFFSIDES
43	prednisolone acetate			OFFSIDES
44	ropinirole			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Duodenal Ulcer	56%
2	Gastric ulcer	56%
3	Zollinger-Ellison syndrome	53.5%
4	Duodenogastric Reflux	46.2%
5	Gastritis	36.7%
6	Duodenal Obstruction	36.1%
7	Duodenitis	35.7%
8	Erosive Duodenitis	35.7%
9	Dysentery	35.1%
10	Enteritis	35.1%
11	Enterocolitis	35.1%
12	Inflammatory Bowel Diseases	35.1%
13	Esophageal Diseases	31.5%
14	Gastroenteritis	31.5%
15	Gastric Dilatation	30.8%
16	Gastric outlet obstruction	30.8%
17	Cecal Diseases	28.6%
18	Colonic Diseases	28.6%
19	Ileal Diseases	28.6%
20	Intestinal Obstruction	28.6%
21	Intestinal Perforation	28.6%
22	Jejunal Diseases	28.6%
23	Pneumatosis Cystoides Intestinalis	28.6%
24	Rectal Diseases	28.6%
25	Cronkhite-Canada Syndrome	28.6%
26	Intestinal Polyposis	28.6%
27	Ileitis	28%
28	Stomach Neoplasms	27.5%
29	Duodenal Neoplasms	27.1%
30	Esophagitis	26.9%
31	Colitis	26.7%
32	Proctitis	26.7%
33	Intestinal Neoplasms	26.4%
34	Gastrointestinal Neoplasms	25.6%
35	Colorectal Neoplasms	25.5%
36	Proctocolitis	25.3%
37	Mesenteric vascular insufficiency	24.2%
38	Intestinal Atresia	23.9%
39	Mesenteric Vascular Occlusion	23.9%
40	Intestinal Fistula	23.8%
41	Enterocutaneous Fistula	23.8%
42	Gastrointestinal Hemorrhage	23.7%
43	Tuberculosis, Gastrointestinal	23.3%
44	Achlorhydria	23.3%
45	Gastric Antral Vascular Ectasia	23.3%
46	Gastroparesis	23.1%
47	Intestinal Diseases, Parasitic	22.7%
48	Crohn Disease	21.7%
49	Enterocolitis, Neutropenic	21.7%
50	Necrotizing Enterocolitis	21.7%
51	Cecal Neoplasms	21.6%
52	Appendicitis	21.5%
53	Superior Mesenteric Artery Syndrome	20.7%
54	Rectal Fistula	20.7%
55	Anal Fistula	20.7%
56	Biliary Tract Diseases	20.2%
57	Liver diseases	20.2%
58	Pancreatic Diseases	20.2%
59	Pyloric Stenosis	19.8%
60	Pouchitis	19.4%
61	Esophageal Neoplasms	18%
62	Esophageal and Gastric Varices	18%
63	Esophageal Stenosis	17.8%
64	Colonic Diseases, Functional	17.6%
65	Fecal Incontinence	17.6%
66	Fecal Impaction	17.6%
67	Intussusception	17.6%
68	Megacolon	17.6%
69	Ileus	17.6%
70	Meconium ileus	17.6%
71	Enterocolitis, Pseudomembranous	17.4%
72	pseudomembranous colitis	17.4%
73	Dysentery, Bacillary	17.4%
74	Esophageal Atresia	17.3%
75	Intestinal Diseases	16.6%
76	Colonic Pseudo-Obstruction	16.3%
77	Digestive System Neoplasms	15.3%
78	Appendiceal Neoplasms	15%
79	Colonic Neoplasms	15%
80	Rectal Neoplasms	15%
81	Stomach Diseases	14.9%
82	Dumping Syndrome	14.9%
83	Anus Neoplasms	14.8%
84	Sigmoid Neoplasms	14.8%
85	Adenomatous Polyposis Coli	14.5%
86	Colitis, Ischemic	14.4%
87	Gastrointestinal Stromal Tumors	14.3%
88	Esophageal Perforation	14.2%
89	Barrett Esophagus	13.7%
90	Deglutition Disorders	13.7%
91	Hemorrhoids	13.6%
92	Afferent Loop Syndrome	13.4%
93	Celiac Disease	13.4%
94	Peptic Ulcer Hemorrhage	13.4%
95	Short Bowel Syndrome	13.4%
96	Sprue, Tropical	13.4%
97	Steatorrhea	13.4%
98	Rectocele	13.4%
99	Sprue	13.4%
100	Rectal Prolapse	13.3%
101	Liver neoplasms	12.8%
102	Pancreatic Fistula	12.7%
103	Anal Fissure	12.2%
104	Intestinal Pseudo-Obstruction	12.2%
105	Irritable Bowel Syndrome	12.2%
106	Neurogenic Bowel	12.2%
107	Anal Ulcer	12.2%
108	Esophageal motility disorders	11.2%
109	Mallory-Weiss Syndrome	11.2%
110	Giardiasis	11%
111	Peptic Ulcer	10.9%
112	Melena	10.9%
113	Hematemesis	10.7%
114	Peritoneal Neoplasms	10.6%
115	Bile Duct Diseases	10.5%
116	Cholelithiasis	10.5%
117	Chylous Ascites	10.5%
118	Fatty Liver	10.5%
119	Hepatitis	10.5%
120	Portal Hypertension	10.5%
121	Liver Cirrhosis	10.5%
122	Pancreatic Insufficiency	10.5%
123	Pancreatitis	10.5%
124	Pneumoperitoneum	10.5%
125	Focal Nodular Hyperplasia	10.5%
126	Hepatic Insufficiency	10.5%
127	Steatohepatitis	10.5%
128	Pruritus Ani	9.3%
129	Pancreatic Neoplasm	9.2%
130	Peutz-Jeghers Syndrome	9%
131	Bile Duct Neoplasms	9%
132	gallbladder neoplasm	9%
133	Cholecystolithiasis	9%
134	Lactose Intolerance	8.9%
135	Biliary cirrhosis	8.8%
136	Diverticulitis	8.4%
137	Choledochal Cyst	8.4%
138	Liver Diseases, Parasitic	8.3%
139	Hepatic Veno-Occlusive Disease	8%
140	Pancreatic Cyst	8%
141	Peliosis Hepatis	8%
142	Hepatopulmonary Syndrome	8%
143	Esophageal Achalasia	8%
144	Anus, Imperforate	7.9%
145	Hemoperitoneum	7.9%
146	Hepatomegaly	7.9%
147	Mesenteric Panniculitis	7.9%
148	Panniculitis, Peritoneal	7.9%
149	Peritonitis	7.9%
150	Peritoneal Fibrosis	7.9%
151	Encapsulating Peritoneal Sclerosis	7.9%
152	Anorectal Malformations	7.9%
153	Biliary Fistula	7.8%
154	Gastric Fistula	7.8%
155	Hepatic Vein Thrombosis	7.8%
156	Liver Abscess	7.8%
157	Budd-Chiari Syndrome	7.8%
158	Choledocholithiasis	7.3%
159	Peptic Ulcer Perforation	7.2%
160	Fatty Liver, Alcoholic	7.1%
161	Hepatitis, Alcoholic	7.1%
162	Liver Cirrhosis, Alcoholic	7.1%
163	Diverticulum	6.9%
164	Diverticulosis	6.9%
165	Cryptosporidiosis	6.8%
166	Chemical and Drug Induced Liver Injury	6.5%
167	Hepatorenal Syndrome	6.3%
168	Hepatocellular Adenoma	6%
169	Cholangitis	5.9%
170	Cholecystitis	5.9%
171	Cholestasis	5.9%
172	Common Bile Duct Diseases	5.9%
173	Hepatitis, Chronic	5.9%
174	Liver Failure	5.9%
175	Pancreatitis, Chronic	5.9%
176	Non-alcoholic Fatty Liver Disease	5.9%
177	Chronic active hepatitis	5.9%
178	Cystic Fibrosis	5.4%
179	Porphyrias, Hepatic	5.3%
180	Congenital Hyperinsulinism	5.3%
181	Liver Abscess, Amebic	5.2%
182	Liver Neoplasms, Experimental	5.2%
183	Laryngopharyngeal Reflux	4.9%
184	Hepatitis, Animal	4.7%
185	Hepatitis, Viral, Human	4.7%
186	Liver Cirrhosis, Experimental	4.5%
187	Pancreatic Pseudocyst	4.5%
188	Pancreatitis, Alcoholic	4.5%
189	Carcinoma, Pancreatic Ductal	4%
190	Cholestasis, Extrahepatic	3.7%
191	Biliary Dyskinesia	3.7%
192	Cholangitis, Sclerosing	3.7%
193	Liver Failure, Acute	3.7%
194	Acalculous Cholecystitis	3.7%
195	End Stage Liver Disease	3.7%
196	Fascioliasis	3.7%
197	Echinococcosis, Hepatic	3.6%
198	Chemical and Drug Induced Liver Injury, Chronic	3.6%
199	Reye Syndrome	3.6%
200	Hepatitis B, Chronic	3.2%
201	Hepatitis C, Chronic	3.2%
202	CREST Syndrome	3%
203	Nesidioblastosis	3%
204	Variegate Porphyria	3%
205	Acute intermittent porphyria	3%
206	Porphyria Cutanea Tarda	3%
207	Autoimmune hepatitis	2.9%
208	insulinoma	2.8%
209	Gastrinoma	2.8%
210	Glucagonoma	2.8%
211	Massive Hepatic Necrosis	2.7%
212	Emphysematous Cholecystitis	2.7%
213	Sphincter of Oddi Dysfunction	2.7%
214	Zellweger Syndrome	2.6%
215	Vipoma	2.5%
216	Hepatitis, Viral, Animal	2.4%
217	Hepatolenticular Degeneration	2.4%
218	Hepatitis E	2.3%
219	Hepatitis B	2.3%
220	Hepatitis C	2.3%
221	Hepatitis A	2.3%
222	Hepatic Encephalopathy	2.3%
223	Rift Valley Fever	1%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120237