MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Liver Failure, Acute

(UMLS:C0162557)

Definition:: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
UMLS ID:: C0162557
MeSH ID:: D017114

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.308.500.750

Synonym(s)

Liver Failure, Acute

ALF - Acute liver failure

Acute Hepatic Failure

Acute Liver Failure

Acute hepatic failure

Acute liver failure

FHF - Fulminant hepatic failure

Fulminant hepatic failure

HEPATIC FAILURE ACUTE

10.

HEPATIC FAILURE FULMINANT

11.

acute failure hepatic

12.

acute failure liver

13.

acute hepatic failure

14.

acute liver failure

15.

failure hepatic acute

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,2,3-trichloropropane	20825388	CTD
2	Acarbose	18648179	CTD
3	Acetaminophen	View details 1354974 1455612 1490760 1602296 1649403 1735538 1825077 1874459 1884059 1904133 1954453 1972496 2124956 2307085 2490426 2910762 3120990 3275027 3364415 3403780 3747662 4018740 4062453 6637917 6779949 7007443 7337133 7364436 7634817 7663656 7672533 7785015 8201209 8209319 8214766 8578195 8666322 8669426 8765723 9057756 9061311 9123096 9148024 9261645 9379757 9468165 9537445 9696492 10212046 10447915 10515538 10615340 10752809 10801061 10806799 10883207 10915174 10919033 10932156 11089752 11182855 11192322 11294286 11588469 11716892 11867109 11927906 12170538 12184014 12484709 12601353 12730105 12755473 12828076 14655058 14696472 14745488 15113342 15344957 15390328 15521608 15672348 15763785 15964424 16116631 16187183 16317692 16378066 16424712 16530510 16799971 16871587 16950959 17058255 17133485 17185352 17262050 17326205 17500339 17600635 17624227 17932004 17971093 18086077 18161937 18216528 18336983 18374145 18433398 18435715 18510596 18609519 18986731 19021948 19183124 19336648 19431953 19436114 19479803 19515070 19590182 19639374 19679878 19715515 19728177 19790165 19918026 20305573 20408947 20538000 20644519 20735774 21127120 21274877 22319198 25239633 25663337 25753323 26718876 27761495 29174983 29246445	CTD
4	Acetylcysteine	View details 1904133 1954453 1972496 7663656 8209319 8765723 9261645 10919033 11588469 12184014 17262050 17500339 18161828 18433398 19524577 19918026	CTD
5	Alcohols	View details 1602296 3364415 3747662 7364436 7634817 11792999 15811896	CTD
6	Aldosterone	1825077	CTD
7	Amiodarone	View details 1752554 4067758 6323638 7797846	CTD
8	Amoxicillin-Potassium Clavulanate Combination	8651842 12481509 16187174	CTD
9	Amoxicillin	8651842 16187174	CTD
10	Aspirin	20167009	CTD
11	Atorvastatin	12765306	CTD
12	Azathioprine	3008617 9212766	CTD
13	Benzbromarone	10845680 12084041	CTD
14	Buprenorphine	18294936	CTD
15	Buthionine Sulfoximine	1735538	CTD
16	Caffeine	22154906	CTD
17	Carbamazepine	View details 2334214 8398372 16033627 16910300 17923349 20879012	CTD
18	Carbon Tetrachloride	3275027 14706259 16899240	CTD
19	Carbon	4134293	CTD
20	Carnitine	10801061	CTD
21	Catechin	1874459	CTD
22	Celecoxib	19701976	CTD
23	Chlorambucil	10922320	CTD
24	Chlorzoxazone	17390222	CTD
25	Ciprofloxacin	12399240 14994731	CTD
26	Clarithromycin	11866297 12503933	CTD
27	Clonazepam	17923349	CTD
28	Clozapine	View details 9136851 10950478 19440569 21165382	CTD
29	Cocaine	11792999 14531175 15013162	CTD
30	Colchicine	15088997	CTD
31	Copper	22140056 23112546	CTD
32	Cyclophosphamide	8946814 19008178 26718876	CTD
33	Cyclosporine	11757752	CTD
34	Cyproterone Acetate	10489919	CTD
35	Cysteine	1874459	CTD
36	D-Galactosamine	View details 16045030 18435715 20558151 21146893 21550386 22154906 24565947 24830863 25620059 28844859 30550845	CTD
37	Danazol	11757752	CTD
38	Desflurane	18759731	CTD
39	Diazepam	16045030	CTD
40	Diclofenac	9474998 11204815	CTD
41	Dicumarol	9548270	CTD
42	Didanosine	View details 1906693 8151270 11450788 16176639	CTD
43	Dimethyl Sulfoxide	2910762	CTD
44	Dimethylnitrosamine	17457977	CTD
45	Diphenhydramine	18986731	CTD
46	Disulfiram	View details 8404476 9625138 15128079 15379082 15811896	CTD
47	Doxycycline	19539102	CTD
48	Dronedarone	20628043	CTD
49	Duloxetine Hydrochloride	16797245	CTD
50	Enalapril	11141678	CTD
51	Ephedrine	15899737	CTD
52	Epoprostenol	15633222	CTD
53	Etodolac	7717333	CTD
54	Ezetimibe, Simvastatin Drug Combination	18752389	CTD
55	Flutamide	View details 8014445 9102495 10215102 10459914 10985104	CTD
56	Galactose	23535186	CTD
57	Glycodeoxycholic Acid	25239633	CTD
58	Halothane	View details 4465472 8023596 8354525 9744690 16085447 17288858 18664874	CTD
59	Hydroxychloroquine	8175002	CTD
60	Ibuprofen	19183124	CTD
61	Imatinib Mesylate	18161937 18362995 19662540	CTD
62	Imipramine	2315196	CTD
63	Isoflurane	9349074 11873055	CTD
64	Isoniazid	View details 6612792 7786350 9661830 10962632 15390328 15717216 16212643 16933231	CTD
65	Ketoconazole	1832694 26718876	CTD
66	Ketoprofen	9881281	CTD
67	Lactic Acid	16750869	CTD
68	Lamivudine	11684562 21186528	CTD
69	Lamotrigine	View details 7633236 17923349 19077780 19221540	CTD
70	Lenalidomide	20011646	CTD
71	Levetiracetam	16910300	CTD
72	Metformin	12639207	CTD
73	Methamphetamine	12136967	CTD
74	Methimazole	2271514	CTD
75	Methotrexate	2287073 20141060	CTD
76	Methoxsalen	8308218	CTD
77	Methylcholanthrene	17971093	CTD
78	Methylprednisolone	17465867	CTD
79	Metronidazole	11941968	CTD
80	Minocycline	11728996	CTD
81	Mirtazapine	16797245	CTD
82	Modafinil	16045030	CTD
83	N-Methyl-3,4-methylenedioxyamphetamine	14531175 16357628	CTD
84	Naproxen	19539102	CTD
85	Nevirapine	View details 15213559 16287519 17133571 17334017 20642694	CTD
86	Niacin	View details 1771885 2355439 2665592 3680913	CTD
87	Nortriptyline	7884180	CTD
88	Ofloxacin	11580158 16105873 19539102	CTD
89	Omeprazole	1553942	CTD
90	Orlistat	16292105	CTD
91	Oxaprozin	7841569	CTD
92	Pemoline	View details 7781270 9565425 12132793 18217792	CTD
93	Phenelzine	8607601	CTD
94	Phenobarbital	17923349 18336983	CTD
95	Phenprocoumon	View details 10545730 11444480 12743448 15455285 16866079	CTD
96	Phenytoin	View details 10915174 10925722 15390328 16187183	CTD
97	Phosphorus	24554916	CTD
98	Pioglitazone	11866308	CTD
99	Piroxicam	12185885	CTD
100	Potassium Permanganate	17932004	CTD
101	Prednisolone	12003403 19662540	CTD
102	Propylthiouracil	View details 3812421 12645809 15390328 15588385 16206173 17457460 20575220	CTD
103	Pyrazinamide	12006469 16212643	CTD
104	Ranitidine	2307085 2910762 10685778	CTD
105	Rifampin	View details 6612792 7786350 12006469 16212643 16933231	CTD
106	Ritonavir	9786823	CTD
107	Rosiglitazone	18397974	CTD
108	Rotenone	24830863	CTD
109	Roxithromycin	11444584	CTD
110	SA 3443	1874459	CTD
111	Sodium Oxybate	15899737	CTD
112	Sorafenib	18796127	CTD
113	Stavudine	12604378	CTD
114	Sulfasalazine	View details 7909645 9776124 10394456 19706026	CTD
115	Sunitinib	19336648	CTD
116	Tamoxifen	26718876	CTD
117	Tenofovir	16176639	CTD
118	Terbinafine	17192859	CTD
119	Thalidomide	17493431	CTD
120	Thioacetamide	View details 12479984 15313186 15633222 17276928 20713078 27899277	CTD
121	Thiopental	16116121	CTD
122	Thyroxine	19336648	CTD
123	Tolcapone	11052337	CTD
124	Topiramate	10915174 17923349	CTD
125	Tramadol	12850423	CTD
126	Trazodone	19857765	CTD
127	Triazolam	12018909	CTD
128	Trimethoprim, Sulfamethoxazole Drug Combination	7202951 7556317 14703931	CTD
129	Troglitazone	View details 10685776 10749332 10989325 12639207 12681458	CTD
130	Ursodeoxycholic Acid	21146893	CTD
131	Valproic Acid	View details 2008603 3922731 6107726 6108469 6769734 7583902 7875849 8479774 8679806 9201347 9258971 10403231 10933322 10950478 12894087 15390328 17923349	CTD
132	Vancomycin	19706026	CTD
133	Venlafaxine Hydrochloride	19857765	CTD
134	benzarone	7776854	CTD
135	bromfenac	10445569	CTD
136	difebarbamate, febarbamate, phenobarbital drug combination	7761807	CTD
137	entecavir	21186528	CTD
138	fludarabine	19008178	CTD
139	gentiopicroside	20558151	CTD
140	geraniol	30550845	CTD
141	isoniazid, pyrazinamide, rifampin drug combination	7705802 8998667	CTD
142	nefazodone	10894614 11048561 12873607	CTD
143	nimesulide	View details 10731303 11549211 17538762 18821716	CTD
144	perhexiline maleate	461164	CTD
145	pirprofen	4007406 8369897	CTD
146	scoparone	23535186	CTD
147	trovafloxacin	10671353	CTD
148	usnic acid	25078063	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	End Stage Liver Disease	48.4%
2	Fatty Liver	25.4%
3	Hepatitis	25.4%
4	Portal Hypertension	25.4%
5	Liver Cirrhosis	25.4%
6	Focal Nodular Hyperplasia	25.4%
7	Steatohepatitis	25.4%
8	Hepatic Encephalopathy	24.4%
9	Liver Diseases, Parasitic	18.1%
10	Hepatic Veno-Occlusive Disease	17.2%
11	Peliosis Hepatis	17.2%
12	Hepatopulmonary Syndrome	17.2%
13	Liver neoplasms	17.1%
14	Hepatomegaly	16.9%
15	Hepatic Vein Thrombosis	16.6%
16	Liver Abscess	16.6%
17	Budd-Chiari Syndrome	16.6%
18	Biliary Tract Diseases	16.4%
19	Gastrointestinal Diseases	16.4%
20	Pancreatic Diseases	16.4%
21	Biliary cirrhosis	15.9%
22	Hepatitis, Chronic	14.8%
23	Non-alcoholic Fatty Liver Disease	14.8%
24	Chronic active hepatitis	14.8%
25	Fatty Liver, Alcoholic	14.7%
26	Hepatitis, Alcoholic	14.7%
27	Liver Cirrhosis, Alcoholic	14.7%
28	Esophageal and Gastric Varices	13.2%
29	Chemical and Drug Induced Liver Injury	13%
30	Hepatorenal Syndrome	12.5%
31	Digestive System Neoplasms	10.8%
32	Hepatitis, Animal	10.6%
33	Hepatitis, Viral, Human	10.6%
34	Porphyrias, Hepatic	10.1%
35	Liver Abscess, Amebic	10%
36	Liver Cirrhosis, Experimental	9.9%
37	Gastrointestinal Neoplasms	8.5%
38	Bile Duct Diseases	8.5%
39	Cholelithiasis	8.5%
40	Chylous Ascites	8.5%
41	Esophageal Diseases	8.5%
42	Gastroenteritis	8.5%
43	Intestinal Diseases	8.5%
44	Pancreatic Fistula	8.5%
45	Pancreatic Insufficiency	8.5%
46	Pancreatitis	8.5%
47	Pneumoperitoneum	8.5%
48	Stomach Diseases	8.5%
49	Hepatocellular Adenoma	7.8%
50	Fascioliasis	7.6%
51	Echinococcosis, Hepatic	7.5%
52	Chemical and Drug Induced Liver Injury, Chronic	7.4%
53	Reye Syndrome	7.4%
54	Mesenteric vascular insufficiency	6.8%
55	Peritoneal Neoplasms	6.8%
56	Hepatitis B, Chronic	6.8%
57	Hepatitis C, Chronic	6.8%
58	Esophageal Atresia	6.7%
59	Intestinal Atresia	6.7%
60	Mesenteric Vascular Occlusion	6.7%
61	Intestinal Fistula	6.7%
62	Enterocutaneous Fistula	6.7%
63	Autoimmune hepatitis	6.7%
64	Liver Neoplasms, Experimental	6.6%
65	Dysentery	6.6%
66	Enteritis	6.6%
67	Enterocolitis	6.6%
68	Esophagitis	6.6%
69	Gastritis	6.6%
70	Inflammatory Bowel Diseases	6.6%
71	Cholecystolithiasis	6.6%
72	Zollinger-Ellison syndrome	6.4%
73	Bile Duct Neoplasms	5.9%
74	gallbladder neoplasm	5.9%
75	Intestinal Neoplasms	5.9%
76	Stomach Neoplasms	5.9%
77	Variegate Porphyria	5.8%
78	Acute intermittent porphyria	5.8%
79	Porphyria Cutanea Tarda	5.8%
80	Pancreatic Cyst	5.7%
81	Pancreatic Neoplasm	5.7%
82	Anus, Imperforate	5.6%
83	Gastrointestinal Hemorrhage	5.6%
84	Hemoperitoneum	5.6%
85	Mesenteric Panniculitis	5.6%
86	Panniculitis, Peritoneal	5.6%
87	Peritonitis	5.6%
88	Peritoneal Fibrosis	5.6%
89	Encapsulating Peritoneal Sclerosis	5.6%
90	Anorectal Malformations	5.6%
91	Biliary Fistula	5.6%
92	Gastric Fistula	5.6%
93	Tuberculosis, Gastrointestinal	5.5%
94	Choledochal Cyst	5.4%
95	Colitis	5.4%
96	Duodenogastric Reflux	5.4%
97	Peptic Ulcer	5.4%
98	Proctitis	5.4%
99	Choledocholithiasis	5.4%
100	Hepatitis, Viral, Animal	5.3%
101	Hepatitis E	5.1%
102	Hepatitis B	5%
103	Hepatitis C	5%
104	Hepatitis A	5%
105	Esophageal Neoplasms	4.9%
106	Cecal Diseases	4.9%
107	Cholangitis	4.9%
108	Cholecystitis	4.9%
109	Cholestasis	4.9%
110	Colonic Diseases	4.9%
111	Common Bile Duct Diseases	4.9%
112	Esophageal Stenosis	4.9%
113	Ileal Diseases	4.9%
114	Intestinal Obstruction	4.9%
115	Intestinal Perforation	4.9%
116	Jejunal Diseases	4.9%
117	Pneumatosis Cystoides Intestinalis	4.9%
118	Rectal Diseases	4.9%
119	Gastric Dilatation	4.9%
120	Pancreatitis, Chronic	4.9%
121	Gastric outlet obstruction	4.9%
122	Gastrointestinal Stromal Tumors	4.9%
123	Cronkhite-Canada Syndrome	4.9%
124	Intestinal Polyposis	4.9%
125	Duodenitis	4.8%
126	Ileitis	4.8%
127	Erosive Duodenitis	4.8%
128	Colorectal Neoplasms	4.6%
129	Proctocolitis	4.5%
130	Rectal Fistula	4.5%
131	Anal Fistula	4.5%
132	Zellweger Syndrome	4.5%
133	Crohn Disease	4.3%
134	Duodenal Obstruction	4.3%
135	Enterocolitis, Neutropenic	4.3%
136	Necrotizing Enterocolitis	4.3%
137	Cecal Neoplasms	4.3%
138	Duodenal Neoplasms	4.3%
139	Appendicitis	4.1%
140	Hepatolenticular Degeneration	4.1%
141	Duodenal Ulcer	3.7%
142	Peptic Ulcer Perforation	3.7%
143	Gastric ulcer	3.7%
144	Pouchitis	3.6%
145	Esophageal Perforation	3.5%
146	Intestinal Diseases, Parasitic	3.5%
147	Cystic Fibrosis	3.5%
148	Barrett Esophagus	3.4%
149	Deglutition Disorders	3.4%
150	Congenital Hyperinsulinism	3.4%
151	Achlorhydria	3.3%
152	Pancreatic Pseudocyst	3.3%
153	Gastric Antral Vascular Ectasia	3.3%
154	Peptic Ulcer Hemorrhage	3.3%
155	Gastroparesis	3.3%
156	Pancreatitis, Alcoholic	3.3%
157	Cholestasis, Extrahepatic	3.2%
158	Biliary Dyskinesia	3.2%
159	Cholangitis, Sclerosing	3.2%
160	Colonic Diseases, Functional	3.2%
161	Enterocolitis, Pseudomembranous	3.2%
162	Esophageal motility disorders	3.2%
163	Fecal Incontinence	3.2%
164	Fecal Impaction	3.2%
165	Intussusception	3.2%
166	Mallory-Weiss Syndrome	3.2%
167	Megacolon	3.2%
168	Pyloric Stenosis	3.2%
169	Acalculous Cholecystitis	3.2%
170	pseudomembranous colitis	3.2%
171	Ileus	3.2%
172	Dysentery, Bacillary	3.2%
173	Meconium ileus	3.2%
174	Appendiceal Neoplasms	3.2%
175	Colonic Neoplasms	3.2%
176	Rectal Neoplasms	3.2%
177	Anus Neoplasms	2.9%
178	Sigmoid Neoplasms	2.9%
179	Colonic Pseudo-Obstruction	2.9%
180	Colitis, Ischemic	2.9%
181	Adenomatous Polyposis Coli	2.6%
182	Melena	2.5%
183	Hematemesis	2.4%
184	Carcinoma, Pancreatic Ductal	2.4%
185	Esophageal Achalasia	2.4%
186	Anal Fissure	2.4%
187	Intestinal Pseudo-Obstruction	2.4%
188	Irritable Bowel Syndrome	2.4%
189	Superior Mesenteric Artery Syndrome	2.4%
190	Emphysematous Cholecystitis	2.4%
191	Neurogenic Bowel	2.4%
192	Sphincter of Oddi Dysfunction	2.4%
193	Anal Ulcer	2.4%
194	Hemorrhoids	2.2%
195	Afferent Loop Syndrome	2.2%
196	Celiac Disease	2.2%
197	Short Bowel Syndrome	2.2%
198	Sprue, Tropical	2.2%
199	Steatorrhea	2.2%
200	Rectocele	2.2%
201	Sprue	2.2%
202	Rift Valley Fever	2.2%
203	Diverticulitis	2.2%
204	Dumping Syndrome	2.2%
205	Rectal Prolapse	2.2%
206	Nesidioblastosis	1.9%
207	insulinoma	1.8%
208	Gastrinoma	1.8%
209	Glucagonoma	1.8%
210	Giardiasis	1.7%
211	Diverticulum	1.7%
212	Diverticulosis	1.7%
213	Pruritus Ani	1.6%
214	Vipoma	1.6%
215	Laryngopharyngeal Reflux	1.4%
216	Peutz-Jeghers Syndrome	1.3%
217	Lactose Intolerance	1.3%
218	Cryptosporidiosis	1%
219	CREST Syndrome	0.7%

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