MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Laryngopharyngeal Reflux

(UMLS:C1168250)

Definition:: Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.
UMLS ID:: C1168250
MeSH ID:: D057045

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.117.119.500.484.500

Classification 2:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.360.577

Synonym(s)

Laryngopharyngeal Reflux

Laryngopharyngeal reflux

laryngopharyngeal reflux

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Lansoprazole	15995512 16845517	CTD
2	Omeprazole	15995512	CTD
3	Ranitidine	15995512	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Esophageal Achalasia	25.5%
2	Laryngitis	22.3%
3	Vocal Cord Dysfunction	22.3%
4	Laryngeal Edema	20.7%
5	Esophagitis	18.8%
6	Granuloma, Laryngeal	18.6%
7	Laryngocele	18.4%
8	Esophageal Stenosis	17.5%
9	Laryngostenosis	16.5%
10	Laryngospasm	16%
11	Laryngeal neoplasm	15.8%
12	Bronchitis	15.1%
13	Croup	15%
14	Esophageal and Gastric Varices	15%
15	Gastroenteritis	14.5%
16	Intestinal Diseases	14.5%
17	Stomach Diseases	14.5%
18	Bronchial Diseases	14.3%
19	Lung diseases	14.3%
20	Pleural Diseases	14.3%
21	Respiration Disorders	14.3%
22	Thoracic Diseases	14.3%
23	Tracheal Diseases	14.3%
24	Esophageal Perforation	13.8%
25	Pleurisy	13.8%
26	Pneumonia	13.8%
27	Lobar Pneumonia	13.8%
28	Respiratory Distress Syndrome, Adult	13.8%
29	Tracheitis	13.8%
30	Pneumonitis	13.8%
31	Tracheobronchomegaly	13.8%
32	Voice Disorders	13.8%
33	Voice Disturbance	13.8%
34	Bronchopneumonia	13.5%
35	Esophageal Atresia	13.5%
36	Barrett Esophagus	13.4%
37	Pleuropneumonia	13.4%
38	Asthma	12.4%
39	Bronchitis, Chronic	12.1%
40	Laryngomalacia	11.8%
41	Esophageal Neoplasms	11.7%
42	Gastrointestinal Neoplasms	11.7%
43	Vocal Cord Paralysis	11.6%
44	Bronchiolitis	11.3%
45	Dysentery	11.3%
46	Enteritis	11.3%
47	Enterocolitis	11.3%
48	Gastritis	11.3%
49	Inflammatory Bowel Diseases	11.3%
50	Nose Diseases	11.1%
51	Lung Diseases, Fungal	11.1%
52	Rhinitis	11.1%
53	Respiratory Distress Syndrome, Newborn	11%
54	Bronchial Fistula	10.9%
55	Lung Abscess	10.9%
56	Lung Neoplasms	10.9%
57	Pleural Neoplasms	10.9%
58	Hoarseness	10.9%
59	Tuberculosis, Pulmonary	10.8%
60	Gastrointestinal Hemorrhage	10.8%
61	Respiratory Tract Infections	10.7%
62	Tuberculosis, Gastrointestinal	10.7%
63	Hepatopulmonary Syndrome	10.6%
64	Granuloma, Respiratory Tract	10.5%
65	Respiratory Hypersensitivity	10.5%
66	Respiratory Tract Fistula	10.5%
67	Zollinger-Ellison syndrome	10.5%
68	Aspiration Pneumonia	10%
69	Aphonia	10%
70	Dysphonia	10%
71	Pleural Effusion, Malignant	9.9%
72	Biliary Tract Diseases	9.9%
73	Liver diseases	9.9%
74	Pancreatic Diseases	9.9%
75	Mallory-Weiss Syndrome	9.6%
76	CREST Syndrome	9.5%
77	Sinusitis	9.5%
78	Bronchial Neoplasms	9.4%
79	Choanal Atresia	9.2%
80	Altitude Sickness	9.1%
81	Atelectasis	9.1%
82	Bronchospasm	9.1%
83	Bronchiectasis	9.1%
84	Chylothorax	9.1%
85	Hydropneumothorax	9.1%
86	Hydrothorax	9.1%
87	Pulmonary Hypertension	9.1%
88	Pneumothorax	9.1%
89	Pulmonary Alveolar Proteinosis	9.1%
90	Pulmonary Edema	9.1%
91	Pulmonary Fibrosis	9.1%
92	Respiratory Insufficiency	9.1%
93	Tracheal Stenosis	9.1%
94	Bronchial Hyperreactivity	9.1%
95	Hamman-Rich syndrome	9.1%
96	Lung Diseases, Interstitial	9.1%
97	Respiratory Depression	9.1%
98	Lung Diseases, Obstructive	9.1%
99	Respiratory Failure	9.1%
100	Idiopathic Pulmonary Fibrosis	9.1%
101	Tracheal Neoplasms	9.1%
102	Aspergillosis, Allergic Bronchopulmonary	9%
103	Intestinal Neoplasms	8.7%
104	Stomach Neoplasms	8.7%
105	Colitis	8.7%
106	Duodenogastric Reflux	8.7%
107	Peptic Ulcer	8.7%
108	Proctitis	8.7%
109	Pneumoconiosis	8.3%
110	Pneumonia, Viral	8.3%
111	Pneumonia, Lipid	8.2%
112	Pneumonia, Bacterial	8.1%
113	Hyaline Membrane Disease	8%
114	Asthma, Exercise-Induced	7.9%
115	Status Asthmaticus	7.9%
116	Multiple Pulmonary Nodules	7.9%
117	Bronchiolitis Obliterans	7.8%
118	Mesenteric vascular insufficiency	7.5%
119	Cecal Diseases	7.5%
120	Colonic Diseases	7.5%
121	Ileal Diseases	7.5%
122	Intestinal Obstruction	7.5%
123	Intestinal Perforation	7.5%
124	Jejunal Diseases	7.5%
125	Pneumatosis Cystoides Intestinalis	7.5%
126	Rectal Diseases	7.5%
127	Gastric Dilatation	7.5%
128	Gastric outlet obstruction	7.5%
129	Cronkhite-Canada Syndrome	7.5%
130	Intestinal Polyposis	7.5%
131	Intestinal Atresia	7.4%
132	Mesenteric Vascular Occlusion	7.4%
133	Intestinal Fistula	7.4%
134	Enterocutaneous Fistula	7.4%
135	Digestive System Neoplasms	7.4%
136	Duodenitis	7.4%
137	Ileitis	7.4%
138	Erosive Duodenitis	7.4%
139	Cystic Fibrosis	7.1%
140	Primary Ciliary Dyskinesia	7.1%
141	Appendicitis	7%
142	Granuloma, Lethal Midline	6.9%
143	Nose Deformities, Acquired	6.9%
144	Lung Injury	6.9%
145	Respiratory Aspiration	6.9%
146	Meconium Aspiration Syndrome	6.9%
147	Asthma, Occupational	6.8%
148	Scimitar Syndrome	6.8%
149	Apnea	6.8%
150	Cheyne-Stokes Respiration	6.8%
151	Common Cold	6.8%
152	Dyspnea	6.8%
153	Hemothorax	6.8%
154	Hyperventilation	6.8%
155	Influenza	6.8%
156	Mouth Breathing	6.8%
157	Tachypnea	6.8%
158	Catarrh	6.8%
159	Pulmonary Embolism	6.7%
160	Radiation Pneumonitis	6.7%
161	Radiation Fibrosis	6.7%
162	Pulmonary Eosinophilia	6.7%
163	Severe Acute Respiratory Syndrome	6.7%
164	Eosinophilic Pneumonia	6.7%
165	Airway Obstruction	6.7%
166	Choking	6.7%
167	Epiglottitis	6.7%
168	Chronic Obstructive Airway Disease	6.7%
169	Mediastinitis	6.7%
170	Middle Lobe Syndrome	6.7%
171	Acute Lung Injury	6.7%
172	Asbestosis	6.7%
173	Berylliosis	6.7%
174	Silicosis	6.7%
175	Acute Chest Syndrome	6.7%
176	Paranasal Sinus Neoplasms	6.6%
177	Colorectal Neoplasms	6.6%
178	Proctocolitis	6.6%
179	Crohn Disease	6.2%
180	Duodenal Obstruction	6.2%
181	Enterocolitis, Neutropenic	6.2%
182	Necrotizing Enterocolitis	6.2%
183	Farmer's Lung	6.1%
184	Nose Neoplasms	6%
185	Hay fever	6%
186	Rhinitis, Allergic, Perennial	6%
187	Rhinoscleroma	6%
188	Gastrointestinal Stromal Tumors	6%
189	Intestinal Diseases, Parasitic	5.9%
190	Liver neoplasms	5.8%
191	Cecal Neoplasms	5.8%
192	Duodenal Neoplasms	5.8%
193	Pancreatic Fistula	5.8%
194	Asthma, Aspirin-Induced	5.7%
195	Achlorhydria	5.6%
196	Gastric Antral Vascular Ectasia	5.6%
197	Peptic Ulcer Hemorrhage	5.6%
198	Gastroparesis	5.6%
199	Pharyngitis	5.6%
200	Pulmonary Emphysema	5.5%
201	Nasal Polyps	5.5%
202	Hemoptysis	5.4%
203	Maxillary Sinus Neoplasms	5.4%
204	Pertussis	5.4%
205	Rectal Fistula	5.3%
206	Anal Fistula	5.3%
207	Kartagener Syndrome	5.3%
208	Mediastinal Cyst	5.1%
209	Pericardial Cyst	5.1%
210	Persistent Fetal Circulation Syndrome	5.1%
211	Thymic Cyst	5.1%
212	Histiocytosis, Langerhans-Cell	5%
213	Mediastinal Emphysema	5%
214	Rhinitis, Vasomotor	5%
215	Pulmonary Aspergillosis	5%
216	Bronchopulmonary Aspergillosis	5%
217	Hypoventilation	5%
218	Acidosis, Respiratory	5%
219	Alkalosis, Respiratory	5%
220	Sarcoidosis, Pulmonary	5%
221	Sleep Apnea Syndromes	5%
222	Blastomycosis	5%
223	Pulmonary Infarction	4.9%
224	Enterocolitis, Pseudomembranous	4.9%
225	pseudomembranous colitis	4.9%
226	Dysentery, Bacillary	4.9%
227	Duodenal Ulcer	4.9%
228	Peptic Ulcer Perforation	4.9%
229	Gastric ulcer	4.9%
230	Bile Duct Diseases	4.8%
231	Cholelithiasis	4.8%
232	Chylous Ascites	4.8%
233	Fatty Liver	4.8%
234	Hepatitis	4.8%
235	Portal Hypertension	4.8%
236	Liver Cirrhosis	4.8%
237	Pancreatic Insufficiency	4.8%
238	Pancreatitis	4.8%
239	Pneumoperitoneum	4.8%
240	Focal Nodular Hyperplasia	4.8%
241	Hepatic Insufficiency	4.8%
242	Steatohepatitis	4.8%
243	Peritoneal Neoplasms	4.8%
244	Epistaxis	4.6%
245	Melena	4.5%
246	Hematemesis	4.4%
247	Pouchitis	4.4%
248	Pancreatic Neoplasm	4.2%
249	Bronchopulmonary Dysplasia	4.1%
250	Colonic Diseases, Functional	4.1%
251	Fecal Incontinence	4.1%
252	Fecal Impaction	4.1%
253	Intussusception	4.1%
254	Megacolon	4.1%
255	Pyloric Stenosis	4.1%
256	Ileus	4.1%
257	Meconium ileus	4.1%
258	Sleep Apnea, Obstructive	4.1%
259	Sleep Apnea, Central	4.1%
260	Tonsillitis	4%
261	Colitis, Ischemic	4%
262	Dyspnea, Paroxysmal	4%
263	Respiratory Paralysis	4%
264	Granulomatosis with polyangiitis	4%
265	Liver Diseases, Parasitic	3.8%
266	Cholecystolithiasis	3.8%
267	Bile Duct Neoplasms	3.7%
268	gallbladder neoplasm	3.7%
269	Choledochal Cyst	3.7%
270	Hepatic Veno-Occlusive Disease	3.7%
271	Pancreatic Cyst	3.7%
272	Peliosis Hepatis	3.7%
273	Anus, Imperforate	3.6%
274	Hemoperitoneum	3.6%
275	Hepatomegaly	3.6%
276	Mesenteric Panniculitis	3.6%
277	Panniculitis, Peritoneal	3.6%
278	Peritonitis	3.6%
279	Peritoneal Fibrosis	3.6%
280	Encapsulating Peritoneal Sclerosis	3.6%
281	Anorectal Malformations	3.6%
282	Biliary Fistula	3.6%
283	Gastric Fistula	3.6%
284	Hepatic Vein Thrombosis	3.6%
285	Liver Abscess	3.6%
286	Budd-Chiari Syndrome	3.6%
287	Biliary cirrhosis	3.5%
288	Appendiceal Neoplasms	3.4%
289	Colonic Neoplasms	3.4%
290	Rectal Neoplasms	3.4%
291	Transfusion-Related Acute Lung Injury	3.4%
292	Adenomatous Polyposis Coli	3.3%
293	Retropharyngeal Abscess	3.3%
294	Anti-Glomerular Basement Membrane Disease	3.3%
295	Bronchomalacia	3.3%
296	Tracheomalacia	3.3%
297	Invasive Pulmonary Aspergillosis	3.3%
298	Hemorrhoids	3.2%
299	Afferent Loop Syndrome	3.1%
300	Celiac Disease	3.1%
301	Short Bowel Syndrome	3.1%
302	Sprue, Tropical	3.1%
303	Steatorrhea	3.1%
304	Rectocele	3.1%
305	Sprue	3.1%
306	Diverticulitis	3.1%
307	Dumping Syndrome	3.1%
308	Rectal Prolapse	3.1%
309	Colonic Pseudo-Obstruction	3%
310	Fatty Liver, Alcoholic	3%
311	Hepatitis, Alcoholic	3%
312	Liver Cirrhosis, Alcoholic	3%
313	Chemical and Drug Induced Liver Injury	3%
314	Anus Neoplasms	2.9%
315	Sigmoid Neoplasms	2.9%
316	Choledocholithiasis	2.9%
317	Nasopharyngitis	2.9%
318	Hepatorenal Syndrome	2.9%
319	Peritonsillar Abscess	2.7%
320	Giardiasis	2.6%
321	Cholangitis	2.5%
322	Cholecystitis	2.5%
323	Cholestasis	2.5%
324	Common Bile Duct Diseases	2.5%
325	Hepatitis, Chronic	2.5%
326	Liver Failure	2.5%
327	Pancreatitis, Chronic	2.5%
328	Non-alcoholic Fatty Liver Disease	2.5%
329	Chronic active hepatitis	2.5%
330	Diverticulum	2.5%
331	Diverticulosis	2.5%
332	Hepatocellular Adenoma	2.5%
333	Anal Fissure	2.5%
334	Intestinal Pseudo-Obstruction	2.5%
335	Irritable Bowel Syndrome	2.5%
336	Superior Mesenteric Artery Syndrome	2.5%
337	Neurogenic Bowel	2.5%
338	Anal Ulcer	2.5%
339	Porphyrias, Hepatic	2.4%
340	Congenital Hyperinsulinism	2.4%
341	Eosinophilic Granuloma	2.4%
342	Liver Abscess, Amebic	2.1%
343	Liver Neoplasms, Experimental	2.1%
344	Peutz-Jeghers Syndrome	2.1%
345	Lactose Intolerance	2.1%
346	Hepatitis, Animal	2%
347	Hepatitis, Viral, Human	2%
348	Liver Cirrhosis, Experimental	1.9%
349	Pancreatic Pseudocyst	1.9%
350	Pancreatitis, Alcoholic	1.9%
351	Pruritus Ani	1.9%
352	Carcinoma, Pancreatic Ductal	1.6%
353	Cryptosporidiosis	1.6%
354	Fascioliasis	1.5%
355	Echinococcosis, Hepatic	1.5%
356	Chemical and Drug Induced Liver Injury, Chronic	1.5%
357	Reye Syndrome	1.5%
358	Cholestasis, Extrahepatic	1.4%
359	Biliary Dyskinesia	1.4%
360	Cholangitis, Sclerosing	1.4%
361	Liver Failure, Acute	1.4%
362	Acalculous Cholecystitis	1.4%
363	End Stage Liver Disease	1.4%
364	Nesidioblastosis	1.2%
365	Variegate Porphyria	1.2%
366	Acute intermittent porphyria	1.2%
367	Porphyria Cutanea Tarda	1.2%
368	Zellweger Syndrome	1.2%
369	Hepatitis B, Chronic	1.1%
370	Hepatitis C, Chronic	1.1%
371	Hepatolenticular Degeneration	1.1%
372	Autoimmune hepatitis	1.1%
373	insulinoma	1%
374	Gastrinoma	1%
375	Glucagonoma	1%
376	Vipoma	0.9%
377	Hepatitis, Viral, Animal	0.9%
378	Hepatitis E	0.9%
379	Hepatitis B	0.8%
380	Hepatitis C	0.8%
381	Hepatitis A	0.8%
382	Hepatic Encephalopathy	0.8%
383	Massive Hepatic Necrosis	0.8%
384	Emphysematous Cholecystitis	0.8%
385	Sphincter of Oddi Dysfunction	0.8%
386	Rift Valley Fever	0.3%

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