MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Biliary cirrhosis

(UMLS:C0023892)

Definition:: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
UMLS ID:: C0023892
MeSH ID:: D008105

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.130.120.135.250.250|C06.552.150.250|C06.552.630.400

Synonym(s)

Biliary cirrhosis

BILIARY CIRRHOSIS

Biliary Cirrhosis

Biliary Liver Cirrhosis

Biliary cirrhosis, unspecified

CIRRHOSIS BILIARY

CIRRHOSIS, CHOLANGIOLITIC BILIARY

Cholangitic cirrhosis

Cholestatic cirrhosis

10.

Cirrhosis, Biliary

11.

LIVER, HYPERTROPHIC CIRRHOSIS OF HANOT

12.

bilary cirrhosis

13.

biliary cirrhosis

14.

biliary cirrhosis liver

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Isotretinoin	FAERS: 3	US FAERS
2	ambrisentan	FAERS: 3	US FAERS
3	telithromycin	FAERS: 3	OFFSIDES US FAERS
4	Atorvastatin	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
5	Quetiapine Fumarate	FAERS: 2	US FAERS
6	Zoledronic Acid	FAERS: 2 Canada Vigilance: 3	Canada Vigilance US FAERS
7	mirabegron	FAERS: 2	US FAERS
8	Arthrotec	FAERS: 1	US FAERS
9	Benicar hct	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
10	Bosentan	FAERS: 1	OFFSIDES US FAERS
11	Celecoxib	FAERS: 1	US FAERS
12	Deferasirox	FAERS: 1	US FAERS
13	Diclofenac	FAERS: 1	US FAERS
14	Epoprostenol	FAERS: 1	US FAERS
15	Exenatide	FAERS: 1	US FAERS
16	Fluticasone-Salmeterol Drug Combination	FAERS: 1	US FAERS
17	Imatinib Mesylate	FAERS: 1	US FAERS
18	Nitrofurantoin	FAERS: 1	OFFSIDES US FAERS
19	Omeprazole	FAERS: 1	US FAERS
20	Quinapril	FAERS: 1	US FAERS
21	Risperidone	FAERS: 1	US FAERS
22	Rivaroxaban	FAERS: 1	US FAERS
23	Sildenafil Citrate	FAERS: 1	US FAERS
24	Ursodeoxycholic Acid	FAERS: 1	US FAERS
25	pramlintide	FAERS: 1	US FAERS
26	rofecoxib	FAERS: 1	US FAERS
27	Bisoprolol		OFFSIDES
28	Chlordiazepoxide		OFFSIDES
29	Doxepin		OFFSIDES
30	Estrogens, Conjugated (USP)	Canada Vigilance: 1	Canada Vigilance
31	Glutamine		OFFSIDES
32	Letrozole		OFFSIDES
33	Medroxyprogesterone Acetate		OFFSIDES
34	Pamidronate		OFFSIDES
35	Pergolide		OFFSIDES
36	Povidone-Iodine		OFFSIDES
37	Raloxifene Hydrochloride		OFFSIDES
38	Tolcapone		OFFSIDES
39	Topiramate		OFFSIDES
40	Trihexyphenidyl		OFFSIDES
41	cerivastatin	Canada Vigilance: 1	Canada Vigilance
42	chlordiazepoxide, clidinium drug combination		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Liver Cirrhosis, Alcoholic	37.7%
2	Fatty Liver	33.9%
3	Hepatitis	33.9%
4	Portal Hypertension	33.9%
5	Focal Nodular Hyperplasia	33.9%
6	Hepatic Insufficiency	33.9%
7	Steatohepatitis	33.9%
8	Liver neoplasms	32.1%
9	Fatty Liver, Alcoholic	29%
10	Hepatitis, Alcoholic	29%
11	Liver Diseases, Parasitic	28.2%
12	Liver Cirrhosis, Experimental	28.1%
13	Hepatic Veno-Occlusive Disease	27.5%
14	Peliosis Hepatis	27.5%
15	Hepatopulmonary Syndrome	27.5%
16	Hepatomegaly	27.1%
17	Hepatic Vein Thrombosis	26.8%
18	Liver Abscess	26.8%
19	Budd-Chiari Syndrome	26.8%
20	Gastrointestinal Diseases	24.7%
21	Pancreatic Diseases	24.7%
22	Esophageal and Gastric Varices	24.4%
23	Bile Duct Neoplasms	24.2%
24	Cholestasis, Extrahepatic	23.3%
25	Chemical and Drug Induced Liver Injury	23.1%
26	Hepatorenal Syndrome	22.4%
27	Liver Abscess, Amebic	22%
28	Hepatitis, Chronic	21.8%
29	Liver Failure	21.8%
30	Non-alcoholic Fatty Liver Disease	21.8%
31	Chronic active hepatitis	21.8%
32	Cholelithiasis	21.3%
33	Cholangitis	21%
34	Common Bile Duct Diseases	21%
35	Choledocholithiasis	21%
36	Cholecystolithiasis	20.5%
37	Choledochal Cyst	20.2%
38	Digestive System Neoplasms	19.9%
39	gallbladder neoplasm	19.5%
40	Porphyrias, Hepatic	19.3%
41	Liver Cirrhosis	18.8%
42	Gastrointestinal Neoplasms	18.6%
43	Biliary cirrhosis	18.6%
44	Pancreatic Fistula	18.5%
45	Zollinger-Ellison syndrome	18.3%
46	Hepatitis, Animal	18.2%
47	Hepatitis, Viral, Human	18.2%
48	Hepatocellular Adenoma	17.3%
49	Biliary Tract Diseases	17.3%
50	Hepatitis B, Chronic	16.5%
51	Hepatitis C, Chronic	16.5%
52	Liver Failure, Acute	15.9%
53	End Stage Liver Disease	15.9%
54	Peritoneal Neoplasms	15.9%
55	Liver Neoplasms, Experimental	15.3%
56	Mesenteric vascular insufficiency	15.2%
57	Esophageal Atresia	15%
58	Intestinal Atresia	15%
59	Mesenteric Vascular Occlusion	15%
60	Intestinal Fistula	15%
61	Enterocutaneous Fistula	15%
62	Intestinal Neoplasms	14.8%
63	Stomach Neoplasms	14.8%
64	Fascioliasis	14.8%
65	Echinococcosis, Hepatic	14.7%
66	Chemical and Drug Induced Liver Injury, Chronic	14.6%
67	Reye Syndrome	14.5%
68	Pancreatic Neoplasm	14%
69	Dysentery	13.9%
70	Enteritis	13.9%
71	Enterocolitis	13.9%
72	Esophagitis	13.9%
73	Gastritis	13.9%
74	Inflammatory Bowel Diseases	13.9%
75	Chylous Ascites	13.8%
76	Esophageal Diseases	13.8%
77	Gastroenteritis	13.8%
78	Intestinal Diseases	13.8%
79	Pancreatic Insufficiency	13.8%
80	Pancreatitis	13.8%
81	Pneumoperitoneum	13.8%
82	Stomach Diseases	13.8%
83	Colorectal Neoplasms	13.5%
84	Biliary Dyskinesia	13.5%
85	Cholangitis, Sclerosing	13.5%
86	Proctocolitis	13.3%
87	Massive Hepatic Necrosis	13%
88	Esophageal Neoplasms	13%
89	Autoimmune hepatitis	13%
90	Cholecystitis	12.8%
91	Variegate Porphyria	12.4%
92	Acute intermittent porphyria	12.4%
93	Porphyria Cutanea Tarda	12.4%
94	Duodenitis	12.2%
95	Ileitis	12.2%
96	Erosive Duodenitis	12.2%
97	Cecal Neoplasms	12.1%
98	Duodenal Neoplasms	12.1%
99	Rectal Fistula	11.9%
100	Anal Fistula	11.9%
101	Colitis	11.8%
102	Duodenogastric Reflux	11.8%
103	Peptic Ulcer	11.8%
104	Proctitis	11.8%
105	Gastrointestinal Stromal Tumors	11.5%
106	Pancreatic Cyst	11.2%
107	Hepatitis, Viral, Animal	11.2%
108	Anus, Imperforate	11%
109	Gastrointestinal Hemorrhage	11%
110	Hemoperitoneum	11%
111	Mesenteric Panniculitis	11%
112	Panniculitis, Peritoneal	11%
113	Peritonitis	11%
114	Peritoneal Fibrosis	11%
115	Encapsulating Peritoneal Sclerosis	11%
116	Anorectal Malformations	11%
117	Biliary Fistula	11%
118	Gastric Fistula	11%
119	Hepatitis E	10.9%
120	Tuberculosis, Gastrointestinal	10.9%
121	Hepatitis B	10.8%
122	Hepatitis C	10.8%
123	Hepatitis A	10.7%
124	Hepatic Encephalopathy	10.6%
125	Zellweger Syndrome	10.2%
126	Bile Duct Diseases	10%
127	Appendicitis	9.9%
128	Crohn Disease	9.8%
129	Duodenal Obstruction	9.8%
130	Enterocolitis, Neutropenic	9.8%
131	Necrotizing Enterocolitis	9.8%
132	Sphincter of Oddi Dysfunction	9.8%
133	Pouchitis	9.7%
134	Appendiceal Neoplasms	9.6%
135	Colonic Neoplasms	9.6%
136	Rectal Neoplasms	9.6%
137	Anus Neoplasms	9.6%
138	Sigmoid Neoplasms	9.6%
139	Hepatolenticular Degeneration	9.5%
140	Duodenal Ulcer	8.8%
141	Peptic Ulcer Perforation	8.8%
142	Gastric ulcer	8.8%
143	Cecal Diseases	8.6%
144	Colonic Diseases	8.6%
145	Esophageal Stenosis	8.6%
146	Ileal Diseases	8.6%
147	Intestinal Obstruction	8.6%
148	Intestinal Perforation	8.6%
149	Jejunal Diseases	8.6%
150	Pneumatosis Cystoides Intestinalis	8.6%
151	Rectal Diseases	8.6%
152	Gastric Dilatation	8.6%
153	Pancreatitis, Chronic	8.6%
154	Gastric outlet obstruction	8.6%
155	Cronkhite-Canada Syndrome	8.6%
156	Intestinal Polyposis	8.6%
157	Acalculous Cholecystitis	8.6%
158	Adenomatous Polyposis Coli	8.5%
159	Enterocolitis, Pseudomembranous	8.1%
160	pseudomembranous colitis	8.1%
161	Dysentery, Bacillary	8.1%
162	Cystic Fibrosis	8.1%
163	Congenital Hyperinsulinism	7.9%
164	Colitis, Ischemic	7.4%
165	Liver diseases	7.4%
166	Colonic Pseudo-Obstruction	7.3%
167	Esophageal Perforation	7.2%
168	Intestinal Diseases, Parasitic	7.2%
169	Barrett Esophagus	7%
170	Deglutition Disorders	7%
171	Achlorhydria	6.9%
172	Pancreatic Pseudocyst	6.9%
173	Gastric Antral Vascular Ectasia	6.9%
174	Peptic Ulcer Hemorrhage	6.9%
175	Gastroparesis	6.9%
176	Pancreatitis, Alcoholic	6.9%
177	Carcinoma, Pancreatic Ductal	6.8%
178	Cholestasis	6.6%
179	Emphysematous Cholecystitis	6.5%
180	Colonic Diseases, Functional	6.1%
181	Esophageal motility disorders	6.1%
182	Fecal Incontinence	6.1%
183	Fecal Impaction	6.1%
184	Intussusception	6.1%
185	Mallory-Weiss Syndrome	6.1%
186	Megacolon	6.1%
187	Pyloric Stenosis	6.1%
188	Ileus	6.1%
189	Meconium ileus	6.1%
190	Rift Valley Fever	5.9%
191	Melena	5.8%
192	Hematemesis	5.7%
193	insulinoma	5.4%
194	Gastrinoma	5.4%
195	Glucagonoma	5.4%
196	Hemorrhoids	5%
197	Afferent Loop Syndrome	4.9%
198	Celiac Disease	4.9%
199	Short Bowel Syndrome	4.9%
200	Sprue, Tropical	4.9%
201	Steatorrhea	4.9%
202	Rectocele	4.9%
203	Sprue	4.9%
204	Nesidioblastosis	4.9%
205	Diverticulitis	4.9%
206	Dumping Syndrome	4.9%
207	Rectal Prolapse	4.9%
208	Esophageal Achalasia	4.9%
209	Anal Fissure	4.9%
210	Intestinal Pseudo-Obstruction	4.9%
211	Irritable Bowel Syndrome	4.9%
212	Superior Mesenteric Artery Syndrome	4.9%
213	Neurogenic Bowel	4.9%
214	Anal Ulcer	4.9%
215	Vipoma	4.8%
216	Giardiasis	4.2%
217	Diverticulum	4.1%
218	Diverticulosis	4.1%
219	Pruritus Ani	3.9%
220	Peutz-Jeghers Syndrome	3.5%
221	Lactose Intolerance	3.5%
222	Laryngopharyngeal Reflux	3.5%
223	Cryptosporidiosis	2.8%
224	CREST Syndrome	2.2%

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