MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Megacolon

(UMLS:C0025160)

Definition:: Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.
UMLS ID:: C0025160
MeSH ID:: D008531

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.158.701

Synonym(s)

Megacolon

COLON NOS DILATATION

Colon dilated

Dilatation of colon

Enlarged colon

MEGACOLON

acquired megacolon

colectasia

colon; dilatation

10.

dilatation; colon

11.

idiopathic megacolon

12.

megacolon

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 65		US FAERS
2	Clozapine	FAERS: 30		OFFSIDES US FAERS
3	Fentanyl	FAERS: 7		US FAERS
4	Alendronate	FAERS: 5		US FAERS
5	Citalopram	FAERS: 5		US FAERS
6	Fidaxomicin	FAERS: 4		SIDER US FAERS
7	Loperamide	FAERS: 4		US FAERS
8	Sunitinib	FAERS: 4		US FAERS
9	Tacrolimus	FAERS: 4		US FAERS
10	Amoxicillin-Potassium Clavulanate Combination	FAERS: 3		US FAERS
11	Carbamazepine	FAERS: 3		US FAERS
12	Cefoxitin	FAERS: 3		OFFSIDES US FAERS
13	Ciprofloxacin	FAERS: 3		OFFSIDES SIDER US FAERS
14	Mesalamine	FAERS: 3		US FAERS
15	Moxifloxacin	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
16	Zoledronic Acid	FAERS: 3		US FAERS
17	Afatinib	FAERS: 2		US FAERS
18	Capecitabine	FAERS: 2		US FAERS
19	Cefotaxime	FAERS: 2		US FAERS
20	Celecoxib	FAERS: 2		US FAERS
21	Clarithromycin	FAERS: 2		US FAERS
22	Clindamycin	FAERS: 2		US FAERS
23	Exenatide	FAERS: 2		US FAERS
24	Glatiramer Acetate	FAERS: 2		OFFSIDES US FAERS
25	Lenalidomide	FAERS: 2		US FAERS
26	Lisinopril	FAERS: 2		US FAERS
27	Meropenem	FAERS: 2		US FAERS
28	Octreotide	FAERS: 2		US FAERS
29	Octreotide	FAERS: 2		US FAERS
30	PCI 32765	FAERS: 2		US FAERS
31	Rifaximin	FAERS: 2		OFFSIDES US FAERS
32	Risperidone	FAERS: 2		US FAERS
33	Rivaroxaban	FAERS: 2		US FAERS
34	Rosiglitazone	FAERS: 2		US FAERS
35	Senna Extract	FAERS: 2		US FAERS
36	Venlafaxine Hydrochloride	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
37	carbidopa, levodopa drug combination	FAERS: 2		US FAERS
38	etonogestrel	FAERS: 2		US FAERS
39	Amitriptyline	FAERS: 1		US FAERS
40	Amoxicillin	FAERS: 1		US FAERS
41	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1		US FAERS
42	Azithromycin	FAERS: 1		US FAERS
43	Bendamustine Hydrochloride	FAERS: 1		US FAERS
44	Ceftriaxone	FAERS: 1		US FAERS
45	Clindamycin	FAERS: 1		US FAERS
46	Cyclosporine	FAERS: 1		US FAERS
47	Dabigatran	FAERS: 1		US FAERS
48	Dabigatran	FAERS: 1		US FAERS
49	Dasatinib	FAERS: 1		US FAERS
50	Dermazin	FAERS: 1		US FAERS
51	Dexmedetomidine	FAERS: 1		US FAERS
52	Erlotinib Hydrochloride	FAERS: 1		US FAERS
53	Everolimus	FAERS: 1		US FAERS
54	Fingolimod Hydrochloride	FAERS: 1		US FAERS
55	Fulvestrant	FAERS: 1		US FAERS
56	Granisetron	FAERS: 1		US FAERS
57	Hydrochlorothiazide	FAERS: 1		US FAERS
58	Imatinib Mesylate	FAERS: 1		US FAERS
59	Ipratropium	FAERS: 1		US FAERS
60	Lactulose	FAERS: 1		US FAERS
61	Leuprolide	FAERS: 1		US FAERS
62	Levofloxacin	FAERS: 1		US FAERS
63	Loperamide	FAERS: 1		SIDER US FAERS
64	MDV 3100	FAERS: 1		US FAERS
65	Magnesium	FAERS: 1		US FAERS
66	Methadone	FAERS: 1		US FAERS
67	Methotrexate	FAERS: 1		US FAERS
68	Methotrexate	FAERS: 1		SIDER US FAERS
69	Metoclopramide	FAERS: 1		US FAERS
70	Metronidazole	FAERS: 1		US FAERS
71	Mifepristone	FAERS: 1		US FAERS
72	Olanzapine	FAERS: 1		US FAERS
73	Quetiapine Fumarate	FAERS: 1		OFFSIDES US FAERS
74	Rivastigmine	FAERS: 1		US FAERS
75	Sertraline	FAERS: 1		US FAERS
76	Simvastatin	FAERS: 1		US FAERS
77	Sulfadiazine	FAERS: 1		US FAERS
78	Sulfasalazine	FAERS: 1		US FAERS
79	Tadalafil	FAERS: 1		US FAERS
80	Thyroxine	FAERS: 1		US FAERS
81	Tiotropium Bromide	FAERS: 1		US FAERS
82	Vancomycin	FAERS: 1		US FAERS
83	Varenicline	FAERS: 1		US FAERS
84	Vincristine	FAERS: 1		US FAERS
85	Vinorelbine	FAERS: 1		OFFSIDES US FAERS
86	clindamycin palmitate	FAERS: 1		US FAERS
87	teduglutide	FAERS: 1		US FAERS
88	ziprasidone	FAERS: 1		US FAERS
89	Acamprosate			OFFSIDES
90	Amantadine			OFFSIDES
91	Amiodarone			OFFSIDES
92	Ampicillin			OFFSIDES
93	Biperiden			OFFSIDES
94	Bisacodyl			OFFSIDES
95	Bleomycin			OFFSIDES
96	Bortezomib			SIDER
97	Cabergoline			OFFSIDES
98	Canrenoic Acid			OFFSIDES
99	Carvedilol			OFFSIDES
100	Cefdinir			OFFSIDES
101	Cefotiam			OFFSIDES
102	Chlorhexidine			OFFSIDES
103	Chloroquine			OFFSIDES
104	Chlorpromazine			SIDER
105	Cimetidine			OFFSIDES
106	Cytarabine			OFFSIDES
107	Daunorubicin			OFFSIDES
108	Dibutyl Phthalate		22027561	CTD
109	Dicyclomine			OFFSIDES
110	Disulfiram			OFFSIDES
111	Etoposide			OFFSIDES
112	Famotidine			OFFSIDES
113	Felbamate			SIDER
114	Flecainide			OFFSIDES
115	Flunitrazepam			OFFSIDES
116	Fluticasone			OFFSIDES
117	Fosfomycin			OFFSIDES SIDER
118	Gemfibrozil			OFFSIDES
119	Gemifloxacin			SIDER
120	Hydrocodone			OFFSIDES
121	Hydrocortisone			OFFSIDES
122	Hydroxyurea			OFFSIDES
123	Irinotecan			SIDER
124	Leflunomide			OFFSIDES
125	Leucovorin			OFFSIDES
126	Lincomycin			SIDER
127	Linezolid			OFFSIDES
128	Lofepramine			OFFSIDES
129	Magnesium Hydroxide			OFFSIDES
130	Methotrimeprazine			OFFSIDES
131	Mitoxantrone			OFFSIDES
132	Mycophenolic Acid			OFFSIDES
133	Nystatin			OFFSIDES
134	Pantoprazole			OFFSIDES
135	Phenytoin			OFFSIDES
136	Piperacillin, Tazobactam Drug Combination			OFFSIDES
137	Prazepam			OFFSIDES
138	Prednisone			OFFSIDES
139	Prochlorperazine			SIDER
140	Saridon			OFFSIDES
141	Sufentanil			OFFSIDES
142	Tazobactam			OFFSIDES
143	Tretinoin			OFFSIDES
144	Triamcinolone Acetonide			OFFSIDES
145	Trifluoperazine			SIDER
146	Trihexyphenidyl			OFFSIDES
147	Trimebutine			OFFSIDES
148	Ubiquinone			OFFSIDES
149	Valproic Acid			OFFSIDES
150	ambrisentan			OFFSIDES
151	benazepril			OFFSIDES
152	cefprozil			OFFSIDES
153	cefuroxime axetil	Canada Vigilance: 1		Canada Vigilance OFFSIDES
154	chlorhexidine gluconate			OFFSIDES
155	cyamemazine			OFFSIDES
156	cyclobenzaprine			OFFSIDES
157	dipropylacetamide			OFFSIDES
158	periciazine			OFFSIDES
159	rasagiline			SIDER
160	tipranavir			OFFSIDES
161	tizanidine			OFFSIDES
162	zafirlukast			OFFSIDES
163	zotepine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Colonic Diseases, Functional	48.4%
2	Colitis	42.4%
3	Irritable Bowel Syndrome	36%
4	Proctocolitis	36%
5	Neurogenic Bowel	36%
6	Cecal Diseases	34.4%
7	Ileal Diseases	34.4%
8	Intestinal Obstruction	34.4%
9	Intestinal Perforation	34.4%
10	Jejunal Diseases	34.4%
11	Pneumatosis Cystoides Intestinalis	34.4%
12	Rectal Diseases	34.4%
13	Cronkhite-Canada Syndrome	34.4%
14	Intestinal Polyposis	34.4%
15	Colonic Pseudo-Obstruction	33.2%
16	Dysentery	33%
17	Enteritis	33%
18	Enterocolitis	33%
19	Inflammatory Bowel Diseases	33%
20	Colorectal Neoplasms	30.3%
21	Duodenal Obstruction	30.1%
22	Duodenitis	27.4%
23	Ileitis	27.4%
24	Erosive Duodenitis	27.4%
25	Esophageal Diseases	25.4%
26	Gastroenteritis	25.4%
27	Stomach Diseases	25.4%
28	Duodenogastric Reflux	25%
29	Peptic Ulcer	25%
30	Proctitis	25%
31	Sigmoid Neoplasms	24.8%
32	Intestinal Diseases, Parasitic	24.7%
33	Zollinger-Ellison syndrome	24%
34	Colitis, Ischemic	23.5%
35	Fecal Incontinence	22.6%
36	Fecal Impaction	22.6%
37	Intussusception	22.6%
38	Ileus	22.6%
39	Meconium ileus	22.6%
40	Mesenteric vascular insufficiency	22.2%
41	Intestinal Atresia	21.8%
42	Mesenteric Vascular Occlusion	21.8%
43	Intestinal Neoplasms	21.7%
44	Intestinal Fistula	21.7%
45	Enterocutaneous Fistula	21.7%
46	Crohn Disease	21.5%
47	Enterocolitis, Neutropenic	21.5%
48	Necrotizing Enterocolitis	21.5%
49	Colonic Neoplasms	20.7%
50	Pouchitis	20.3%
51	Rectal Fistula	20.1%
52	Anal Fistula	20.1%
53	Esophagitis	19.8%
54	Gastritis	19.8%
55	Cecal Neoplasms	19.3%
56	Duodenal Neoplasms	19.3%
57	Appendicitis	18.9%
58	Duodenal Ulcer	17.6%
59	Peptic Ulcer Perforation	17.6%
60	Gastric ulcer	17.6%
61	Adenomatous Polyposis Coli	17.1%
62	Gastrointestinal Neoplasms	17.1%
63	Gastrointestinal Hemorrhage	16.9%
64	Anal Fissure	16.8%
65	Intestinal Pseudo-Obstruction	16.8%
66	Superior Mesenteric Artery Syndrome	16.8%
67	Anal Ulcer	16.8%
68	Tuberculosis, Gastrointestinal	16.5%
69	Biliary Tract Diseases	16.4%
70	Liver diseases	16.4%
71	Pancreatic Diseases	16.4%
72	Enterocolitis, Pseudomembranous	16.1%
73	pseudomembranous colitis	16.1%
74	Dysentery, Bacillary	16.1%
75	Hemorrhoids	15.6%
76	Afferent Loop Syndrome	15.2%
77	Celiac Disease	15.2%
78	Short Bowel Syndrome	15.2%
79	Sprue, Tropical	15.2%
80	Steatorrhea	15.2%
81	Rectocele	15.2%
82	Sprue	15.2%
83	Rectal Prolapse	15.1%
84	Anus Neoplasms	14.9%
85	Esophageal Stenosis	14.8%
86	Gastric Dilatation	14.8%
87	Gastric outlet obstruction	14.8%
88	Appendiceal Neoplasms	14.3%
89	Rectal Neoplasms	14.3%
90	Stomach Neoplasms	13.8%
91	Esophageal and Gastric Varices	13.2%
92	Giardiasis	11.9%
93	Esophageal Atresia	11.8%
94	Esophageal Neoplasms	11.5%
95	Pruritus Ani	11.4%
96	Digestive System Neoplasms	10.8%
97	Esophageal Perforation	10.6%
98	Barrett Esophagus	10.1%
99	Deglutition Disorders	10.1%
100	Achlorhydria	9.9%
101	Gastric Antral Vascular Ectasia	9.9%
102	Gastrointestinal Stromal Tumors	9.8%
103	Peptic Ulcer Hemorrhage	9.8%
104	Gastroparesis	9.8%
105	Esophageal motility disorders	9.7%
106	Mallory-Weiss Syndrome	9.7%
107	Pyloric Stenosis	9.7%
108	Peutz-Jeghers Syndrome	9.2%
109	Lactose Intolerance	9.1%
110	Liver neoplasms	8.5%
111	Bile Duct Diseases	8.5%
112	Cholelithiasis	8.5%
113	Chylous Ascites	8.5%
114	Fatty Liver	8.5%
115	Hepatitis	8.5%
116	Portal Hypertension	8.5%
117	Liver Cirrhosis	8.5%
118	Pancreatic Fistula	8.5%
119	Pancreatic Insufficiency	8.5%
120	Pancreatitis	8.5%
121	Pneumoperitoneum	8.5%
122	Focal Nodular Hyperplasia	8.5%
123	Hepatic Insufficiency	8.5%
124	Steatohepatitis	8.5%
125	Melena	7.5%
126	Hematemesis	7.3%
127	Esophageal Achalasia	7.2%
128	Peritoneal Neoplasms	6.8%
129	Cryptosporidiosis	6.7%
130	Cholecystolithiasis	6.6%
131	Diverticulitis	6.5%
132	Dumping Syndrome	6.5%
133	Biliary cirrhosis	6.1%
134	Liver Diseases, Parasitic	6%
135	Bile Duct Neoplasms	5.9%
136	gallbladder neoplasm	5.9%
137	Hepatic Veno-Occlusive Disease	5.7%
138	Pancreatic Cyst	5.7%
139	Peliosis Hepatis	5.7%
140	Hepatopulmonary Syndrome	5.7%
141	Pancreatic Neoplasm	5.7%
142	Anus, Imperforate	5.6%
143	Hemoperitoneum	5.6%
144	Hepatomegaly	5.6%
145	Mesenteric Panniculitis	5.6%
146	Panniculitis, Peritoneal	5.6%
147	Peritonitis	5.6%
148	Peritoneal Fibrosis	5.6%
149	Encapsulating Peritoneal Sclerosis	5.6%
150	Anorectal Malformations	5.6%
151	Biliary Fistula	5.6%
152	Gastric Fistula	5.6%
153	Hepatic Vein Thrombosis	5.5%
154	Liver Abscess	5.5%
155	Budd-Chiari Syndrome	5.5%
156	Choledochal Cyst	5.4%
157	Choledocholithiasis	5.4%
158	Diverticulum	5%
159	Diverticulosis	5%
160	Cholangitis	4.9%
161	Cholecystitis	4.9%
162	Cholestasis	4.9%
163	Common Bile Duct Diseases	4.9%
164	Hepatitis, Chronic	4.9%
165	Liver Failure	4.9%
166	Pancreatitis, Chronic	4.9%
167	Non-alcoholic Fatty Liver Disease	4.9%
168	Chronic active hepatitis	4.9%
169	Fatty Liver, Alcoholic	4.9%
170	Hepatitis, Alcoholic	4.9%
171	Liver Cirrhosis, Alcoholic	4.9%
172	Chemical and Drug Induced Liver Injury	4.3%
173	Hepatorenal Syndrome	4.2%
174	Laryngopharyngeal Reflux	4.1%
175	Hepatocellular Adenoma	3.9%
176	Hepatitis, Animal	3.5%
177	Hepatitis, Viral, Human	3.5%
178	Cystic Fibrosis	3.5%
179	Porphyrias, Hepatic	3.4%
180	Congenital Hyperinsulinism	3.4%
181	Liver Abscess, Amebic	3.3%
182	Liver Neoplasms, Experimental	3.3%
183	Liver Cirrhosis, Experimental	3.3%
184	Pancreatic Pseudocyst	3.3%
185	Pancreatitis, Alcoholic	3.3%
186	Cholestasis, Extrahepatic	3.2%
187	Biliary Dyskinesia	3.2%
188	Cholangitis, Sclerosing	3.2%
189	Liver Failure, Acute	3.2%
190	Acalculous Cholecystitis	3.2%
191	End Stage Liver Disease	3.2%
192	Fascioliasis	2.5%
193	Echinococcosis, Hepatic	2.5%
194	Chemical and Drug Induced Liver Injury, Chronic	2.5%
195	Reye Syndrome	2.5%
196	Carcinoma, Pancreatic Ductal	2.4%
197	Massive Hepatic Necrosis	2.4%
198	Emphysematous Cholecystitis	2.4%
199	Sphincter of Oddi Dysfunction	2.4%
200	Hepatitis B, Chronic	2.3%
201	Hepatitis C, Chronic	2.3%
202	Autoimmune hepatitis	2.2%
203	CREST Syndrome	2.1%
204	Nesidioblastosis	1.9%
205	Variegate Porphyria	1.9%
206	Acute intermittent porphyria	1.9%
207	Porphyria Cutanea Tarda	1.9%
208	insulinoma	1.8%
209	Gastrinoma	1.8%
210	Glucagonoma	1.8%
211	Hepatitis, Viral, Animal	1.8%
212	Hepatitis E	1.7%
213	Hepatitis B	1.7%
214	Hepatitis C	1.7%
215	Hepatitis A	1.7%
216	Hepatic Encephalopathy	1.6%
217	Vipoma	1.6%
218	Zellweger Syndrome	1.5%
219	Hepatolenticular Degeneration	1.4%
220	Rift Valley Fever	0.7%

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