MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hepatitis E

(UMLS:C0085293)

Definition:: Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.
UMLS ID:: C0085293
MeSH ID:: D016751

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.440.470|C02.782.455

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.380.705.470

Synonym(s)

Hepatitis E

Hepatitis E virus infection

Viral hepatitis E

Viral hepatitis type E

e hepatitis

hepatitis e

hepatitis; virus, type E

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Methotrexate	FAERS: 13	US FAERS
2	Tacrolimus	FAERS: 4	US FAERS
3	Amoxicillin-Potassium Clavulanate Combination	FAERS: 3	US FAERS
4	Imatinib Mesylate	FAERS: 3 Canada Vigilance: 1	Canada Vigilance US FAERS
5	Ribavirin	FAERS: 3	US FAERS
6	Ruxolitinib phosphate	FAERS: 3	US FAERS
7	baricitinib	FAERS: 3	US FAERS
8	Allopurinol	FAERS: 2	US FAERS
9	Azithromycin	FAERS: 2	US FAERS
10	Methylphenidate	FAERS: 2	US FAERS
11	Minocycline	FAERS: 2	US FAERS
12	PCI 32765	FAERS: 2	US FAERS
13	Prednisolone	FAERS: 2	US FAERS
14	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1	US FAERS
15	Amlodipine	FAERS: 1	US FAERS
16	Azacitidine	FAERS: 1	US FAERS
17	Bosentan	FAERS: 1	US FAERS
18	Carbamazepine	FAERS: 1	US FAERS
19	Crizotinib	FAERS: 1	US FAERS
20	Cyclosporine	FAERS: 1	US FAERS
21	Dimethyl Fumarate	FAERS: 1	US FAERS
22	Ezetimibe	FAERS: 1	US FAERS
23	Fingolimod Hydrochloride	FAERS: 1	US FAERS
24	Flutamide	FAERS: 1	US FAERS
25	Isotretinoin	FAERS: 1	US FAERS
26	Meloxicam	FAERS: 1	US FAERS
27	Methotrexate	FAERS: 1	US FAERS
28	Minocycline	FAERS: 1	US FAERS
29	Pramipexole	FAERS: 1	US FAERS
30	Rivaroxaban	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
31	Rosiglitazone	FAERS: 1	US FAERS
32	Tadalafil	FAERS: 1	US FAERS
33	Telmisartan	FAERS: 1	US FAERS
34	Thyroxine	FAERS: 1	US FAERS
35	apixaban	FAERS: 1	US FAERS
36	candesartan cilexetil	FAERS: 1	US FAERS
37	montelukast	FAERS: 1	US FAERS
38	pirfenidone	FAERS: 1	US FAERS
39	prednisolone phosphate	FAERS: 1	US FAERS
40	Acetylcysteine		OFFSIDES
41	Cromolyn Sodium		OFFSIDES
42	Darunavir		OFFSIDES
43	Naproxen		OFFSIDES
44	Tenofovir		OFFSIDES
45	Zidovudine		OFFSIDES
46	cefpodoxime proxetil		OFFSIDES
47	cefpodoxime		OFFSIDES
48	lamivudine, zidovudine drug combination		OFFSIDES
49	telithromycin		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hepatitis C	48.9%
2	Hepatitis A	46.3%
3	Hepatitis B	42%
4	Hepatitis C, Chronic	38.2%
5	Rift Valley Fever	34.2%
6	Dengue Fever	34.1%
7	Yellow Fever	34.1%
8	Hemorrhagic Fever, Crimean	33.9%
9	Hepatitis B, Chronic	33.5%
10	Hemorrhagic Fever, American	32.7%
11	Lassa Fever	32.7%
12	Hemorrhagic Fever with Renal Syndrome	29.7%
13	Orthomyxoviridae Infections	27.8%
14	Picornaviridae Infections	27.8%
15	Reoviridae Infections	27.8%
16	Retroviridae Infections	27.8%
17	Phlebotomus Fever	27.6%
18	Zika Virus Infection	24.7%
19	Herpangina	24%
20	West Nile Fever	23.3%
21	Murine Acquired Immunodeficiency Syndrome	23.1%
22	Hepatitis, Viral, Animal	22.4%
23	Arbovirus Infections	21.6%
24	Warts	21.6%
25	Acquired Immunodeficiency Syndrome	21.2%
26	AIDS related complex	21.2%
27	Enterovirus Infections	20.5%
28	Flavivirus Infections	20.5%
29	Paramyxoviridae Infections	20.5%
30	Cardiovirus Infections	20.5%
31	Rhabdoviridae Infections	20.5%
32	Simian Acquired Immunodeficiency Syndrome	20.5%
33	Subacute Sclerosing Panencephalitis	20.4%
34	Epstein-Barr Virus Infections	19.3%
35	Condylomata Acuminata	19.2%
36	HIV Infections	18.2%
37	Hepatitis, Chronic	17.9%
38	Chronic active hepatitis	17.9%
39	Foot-and-Mouth Disease	17%
40	Coxsackievirus Infections	16.9%
41	Rubella	16.9%
42	Coronavirus Infections	16.9%
43	Nipah Virus Infection	16.9%
44	Hydrophobia	16.9%
45	Viremia	16.8%
46	Hepatitis, Alcoholic	16.8%
47	Common Cold	16.6%
48	Influenza	16.6%
49	Catarrh	16.6%
50	Epidermodysplasia Verruciformis	16.2%
51	Molluscum Contagiosum	15.9%
52	Leukoencephalopathy, Progressive Multifocal	15.7%
53	HIV Seropositivity	15.6%
54	Measles	15.2%
55	Pleurodynia, Epidemic	15.2%
56	Respiratory Syncytial Virus Infections	15.2%
57	Hepatitis, Animal	14.9%
58	Opportunistic Infections	14.7%
59	AIDS-Related Opportunistic Infections	14.5%
60	Herpes Zoster Ophthalmicus	14.2%
61	Pneumonia, Viral	14%
62	Pseudorabies	14%
63	Herpesviridae Infections	13.9%
64	Polyomavirus Infections	13.9%
65	Porcine Reproductive and Respiratory Syndrome	13.7%
66	Erythema Infectiosum	13.6%
67	HTLV-I Infections	13.5%
68	Fatty Liver	13%
69	Portal Hypertension	13%
70	Liver Cirrhosis	13%
71	Focal Nodular Hyperplasia	13%
72	Hepatic Insufficiency	13%
73	Steatohepatitis	13%
74	Keratitis, Herpetic	12.6%
75	Cytomegalovirus Retinitis	12.6%
76	Exanthema Subitum	12.6%
77	Gastroenteritis, Transmissible, of Swine	12.3%
78	Severe Acute Respiratory Syndrome	12.3%
79	Eczema Herpeticum	12.3%
80	Chronic Fatigue Syndrome	12.2%
81	Sexually Transmitted Diseases	12.2%
82	Mumps	12%
83	HIV Wasting Syndrome	11.7%
84	AIDS Dementia Complex	11.6%
85	AIDS-Associated Nephropathy	11.6%
86	Vesicular Stomatitis	11.6%
87	Liver neoplasms	11.6%
88	Biliary cirrhosis	10.9%
89	Liver Diseases, Parasitic	10.8%
90	Genital Herpes	10.7%
91	Herpes Labialis	10.5%
92	Hepatic Veno-Occlusive Disease	10.5%
93	Peliosis Hepatis	10.5%
94	Hepatopulmonary Syndrome	10.5%
95	Hepatomegaly	10.3%
96	HIV-Associated Lipodystrophy Syndrome	10.3%
97	Cytomegalovirus Infections	10.3%
98	Smallpox	10.3%
99	Varicella Zoster Virus Infection	10.3%
100	Hepatic Vein Thrombosis	10.2%
101	Liver Abscess	10.2%
102	Budd-Chiari Syndrome	10.2%
103	Fatty Liver, Alcoholic	10.1%
104	Liver Cirrhosis, Alcoholic	10.1%
105	Poliomyelitis	9.6%
106	Autoimmune hepatitis	9.6%
107	Superinfection	9.2%
108	Hepatitis E	9.2%
109	Burkitt Lymphoma	9.1%
110	Chemical and Drug Induced Liver Injury	8.8%
111	Hepatorenal Syndrome	8.5%
112	Hepatitis, Viral, Human	8.5%
113	Chickenpox	8.5%
114	Esophageal and Gastric Varices	8.2%
115	Biliary Tract Diseases	8.1%
116	Gastrointestinal Diseases	8.1%
117	Pancreatic Diseases	8.1%
118	Liver Failure	7.7%
119	Non-alcoholic Fatty Liver Disease	7.7%
120	Liver Abscess, Amebic	7.6%
121	Porphyrias, Hepatic	7.3%
122	Digestive System Neoplasms	6.5%
123	Liver Cirrhosis, Experimental	6.1%
124	Bell Palsy	5.9%
125	Gastrointestinal Neoplasms	5.8%
126	Pancreatic Fistula	5.7%
127	Hepatocellular Adenoma	5.7%
128	Zollinger-Ellison syndrome	5.2%
129	Fascioliasis	5.1%
130	Echinococcosis, Hepatic	5.1%
131	Liver Failure, Acute	5.1%
132	End Stage Liver Disease	5.1%
133	Chemical and Drug Induced Liver Injury, Chronic	5.1%
134	Liver Neoplasms, Experimental	5.1%
135	Reye Syndrome	5.1%
136	Peritoneal Neoplasms	4.9%
137	Infectious Mononucleosis	4.8%
138	Mesenteric vascular insufficiency	4.6%
139	Esophageal Atresia	4.6%
140	Intestinal Atresia	4.6%
141	Mesenteric Vascular Occlusion	4.6%
142	Intestinal Fistula	4.5%
143	Enterocutaneous Fistula	4.5%
144	Herpes Zoster Oticus	4.4%
145	Bile Duct Diseases	4.3%
146	Cholelithiasis	4.3%
147	Chylous Ascites	4.3%
148	Esophageal Diseases	4.3%
149	Gastroenteritis	4.3%
150	Intestinal Diseases	4.3%
151	Pancreatic Insufficiency	4.3%
152	Pancreatitis	4.3%
153	Pneumoperitoneum	4.3%
154	Stomach Diseases	4.3%
155	Pancreatic Neoplasm	4.3%
156	Bile Duct Neoplasms	4.3%
157	gallbladder neoplasm	4.3%
158	Intestinal Neoplasms	4.3%
159	Stomach Neoplasms	4.3%
160	Variegate Porphyria	4.3%
161	Acute intermittent porphyria	4.3%
162	Porphyria Cutanea Tarda	4.3%
163	Dysentery	4.1%
164	Enteritis	4.1%
165	Enterocolitis	4.1%
166	Esophagitis	4.1%
167	Gastritis	4.1%
168	Inflammatory Bowel Diseases	4.1%
169	Cholecystolithiasis	4.1%
170	Choledochal Cyst	3.9%
171	Zellweger Syndrome	3.8%
172	Massive Hepatic Necrosis	3.8%
173	Esophageal Neoplasms	3.8%
174	Colorectal Neoplasms	3.7%
175	Hepatolenticular Degeneration	3.6%
176	Pancreatic Cyst	3.5%
177	Proctocolitis	3.5%
178	Anus, Imperforate	3.4%
179	Gastrointestinal Hemorrhage	3.4%
180	Hemoperitoneum	3.4%
181	Mesenteric Panniculitis	3.4%
182	Panniculitis, Peritoneal	3.4%
183	Peritonitis	3.4%
184	Peritoneal Fibrosis	3.4%
185	Encapsulating Peritoneal Sclerosis	3.4%
186	Anorectal Malformations	3.4%
187	Biliary Fistula	3.4%
188	Gastric Fistula	3.4%
189	Tuberculosis, Gastrointestinal	3.4%
190	Colitis	3.4%
191	Duodenogastric Reflux	3.4%
192	Peptic Ulcer	3.4%
193	Proctitis	3.4%
194	Choledocholithiasis	3.4%
195	Gastrointestinal Stromal Tumors	3.4%
196	Hepatic Encephalopathy	3.4%
197	Duodenitis	3.3%
198	Ileitis	3.3%
199	Erosive Duodenitis	3.3%
200	Rectal Fistula	3.3%
201	Anal Fistula	3.3%
202	Cecal Neoplasms	3.3%
203	Duodenal Neoplasms	3.3%
204	Appendicitis	2.8%
205	Crohn Disease	2.7%
206	Duodenal Obstruction	2.7%
207	Enterocolitis, Neutropenic	2.7%
208	Necrotizing Enterocolitis	2.7%
209	Cecal Diseases	2.6%
210	Cholangitis	2.6%
211	Cholecystitis	2.6%
212	Cholestasis	2.6%
213	Colonic Diseases	2.6%
214	Common Bile Duct Diseases	2.6%
215	Esophageal Stenosis	2.6%
216	Ileal Diseases	2.6%
217	Intestinal Obstruction	2.6%
218	Intestinal Perforation	2.6%
219	Jejunal Diseases	2.6%
220	Pneumatosis Cystoides Intestinalis	2.6%
221	Rectal Diseases	2.6%
222	Gastric Dilatation	2.6%
223	Pancreatitis, Chronic	2.6%
224	Gastric outlet obstruction	2.6%
225	Cronkhite-Canada Syndrome	2.6%
226	Intestinal Polyposis	2.6%
227	Cystic Fibrosis	2.5%
228	Pouchitis	2.5%
229	Appendiceal Neoplasms	2.5%
230	Colonic Neoplasms	2.5%
231	Rectal Neoplasms	2.5%
232	Congenital Hyperinsulinism	2.4%
233	Anus Neoplasms	2.3%
234	Sigmoid Neoplasms	2.3%
235	Duodenal Ulcer	2.3%
236	Peptic Ulcer Perforation	2.3%
237	Gastric ulcer	2.3%
238	Enterocolitis, Pseudomembranous	2.2%
239	pseudomembranous colitis	2.2%
240	Dysentery, Bacillary	2.2%
241	Adenomatous Polyposis Coli	2.2%
242	Esophageal Perforation	2.1%
243	Intestinal Diseases, Parasitic	2.1%
244	Barrett Esophagus	2.1%
245	Deglutition Disorders	2.1%
246	Achlorhydria	2%
247	Pancreatic Pseudocyst	2%
248	Gastric Antral Vascular Ectasia	2%
249	Peptic Ulcer Hemorrhage	2%
250	Gastroparesis	2%
251	Pancreatitis, Alcoholic	2%
252	Carcinoma, Pancreatic Ductal	2%
253	Colitis, Ischemic	2%
254	Colonic Pseudo-Obstruction	1.8%
255	Melena	1.7%
256	Cholestasis, Extrahepatic	1.7%
257	Biliary Dyskinesia	1.7%
258	Cholangitis, Sclerosing	1.7%
259	Colonic Diseases, Functional	1.7%
260	Esophageal motility disorders	1.7%
261	Fecal Incontinence	1.7%
262	Fecal Impaction	1.7%
263	Intussusception	1.7%
264	Mallory-Weiss Syndrome	1.7%
265	Megacolon	1.7%
266	Pyloric Stenosis	1.7%
267	Acalculous Cholecystitis	1.7%
268	Ileus	1.7%
269	Meconium ileus	1.7%
270	Hematemesis	1.7%
271	insulinoma	1.5%
272	Gastrinoma	1.5%
273	Glucagonoma	1.5%
274	Nesidioblastosis	1.4%
275	Hemorrhoids	1.4%
276	Afferent Loop Syndrome	1.4%
277	Celiac Disease	1.4%
278	Short Bowel Syndrome	1.4%
279	Sprue, Tropical	1.4%
280	Steatorrhea	1.4%
281	Rectocele	1.4%
282	Sprue	1.4%
283	Diverticulitis	1.3%
284	Dumping Syndrome	1.3%
285	Rectal Prolapse	1.3%
286	Vipoma	1.3%
287	Esophageal Achalasia	1.3%
288	Anal Fissure	1.3%
289	Intestinal Pseudo-Obstruction	1.3%
290	Irritable Bowel Syndrome	1.3%
291	Superior Mesenteric Artery Syndrome	1.3%
292	Emphysematous Cholecystitis	1.3%
293	Neurogenic Bowel	1.3%
294	Sphincter of Oddi Dysfunction	1.3%
295	Anal Ulcer	1.3%
296	Giardiasis	1.1%
297	Diverticulum	1.1%
298	Diverticulosis	1.1%
299	Pruritus Ani	1%
300	Peutz-Jeghers Syndrome	1%
301	Lactose Intolerance	1%
302	Laryngopharyngeal Reflux	0.9%
303	Cryptosporidiosis	0.8%
304	CREST Syndrome	0.6%

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