MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Massive Hepatic Necrosis

(UMLS:C0001364)

Definition:: Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials or drug-induced injury. It is characterized by a soft, flabby, yellow-brown wrinkled, and shrunken liver. It was called "acute yellow atrophy".
UMLS ID:: C0001364
MeSH ID:: D047508

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.308.500.750.500

Synonym(s)

Massive Hepatic Necrosis

Acute hepatic necrosis

Acute necrosis of liver

Acute yellow atrophy

Acute yellow atrophy of liver

Acute yellow liver atrophy

Atrophy, acute yellow

HEPATIC NECROSIS, MASSIVE

LIVER, ACUTE YELLOW ATROPHY

10.

Massive hepatic necrosis

11.

acute atrophy yellow

12.

acute hepatic necrosis

13.

acute necrosis of liver

14.

acute yellow atrophy

15.

hepatic necrosis acute

16.

massive hepatic necrosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-Naphthylisothiocyanate	29660435	CTD
2	1-aminobenzotriazole	27421776	CTD
3	1-bromopropane	27421776	CTD
4	Acetaminophen	17962186 25448281 29246445	CTD
5	Carbon Tetrachloride	28527913	CTD
6	D-Galactosamine	17963606 28213090	CTD
7	Ethionine	22575522	CTD
8	Glycyrrhetinic Acid	28213090	CTD
9	Halothane	5725736	CTD
10	Imipramine	2315196	CTD
11	Ketoconazole	4007605 6319220	CTD
12	Levetiracetam	18725594	CTD
13	Methimazole	2484903	CTD
14	Methyldopa	77129 4688573 7323715	CTD
15	Monocrotaline	21224054 22407844	CTD
16	Niacin	1771885	CTD
17	Orlistat	11211898	CTD
18	Phenobarbital	17962186	CTD
19	Phenprocoumon	10545730 15246210	CTD
20	Phenytoin	View details 814030 3093562 11100060 21224054	CTD
21	Pyrazinamide	6118518 22431067	CTD
22	Rifampin	21224054	CTD
23	Silymarin	28454924	CTD
24	Sulfasalazine	1348259 16283166	CTD
25	Trimethoprim, Sulfamethoxazole Drug Combination	11100060	CTD
26	Troglitazone	9839107	CTD
27	Valproic Acid	10701024	CTD
28	artemisinine	17962186	CTD
29	obeticholic acid	29660435	CTD
30	perhexiline maleate	6123804	CTD
31	pirinixic acid	17962186	CTD
32	pirprofen	4007406	CTD
33	pregna-4,17-diene-3,16-dione	29660435	CTD
34	trovafloxacin	18930950	CTD
35	yangonin	29660435	CTD
36	zafirlukast	11682043	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	End Stage Liver Disease	36%
2	Fatty Liver	22.7%
3	Hepatitis	22.7%
4	Portal Hypertension	22.7%
5	Liver Cirrhosis	22.7%
6	Focal Nodular Hyperplasia	22.7%
7	Steatohepatitis	22.7%
8	Hepatic Encephalopathy	18.2%
9	Liver Diseases, Parasitic	16.2%
10	Hepatic Veno-Occlusive Disease	15.4%
11	Peliosis Hepatis	15.4%
12	Hepatopulmonary Syndrome	15.4%
13	Liver neoplasms	15.3%
14	Biliary Tract Diseases	15.3%
15	Gastrointestinal Diseases	15.3%
16	Pancreatic Diseases	15.3%
17	Hepatomegaly	15.1%
18	Hepatic Vein Thrombosis	14.8%
19	Liver Abscess	14.8%
20	Budd-Chiari Syndrome	14.8%
21	Biliary cirrhosis	13%
22	Fatty Liver, Alcoholic	12.2%
23	Hepatitis, Alcoholic	12.2%
24	Hepatitis, Chronic	12.2%
25	Liver Cirrhosis, Alcoholic	12.2%
26	Non-alcoholic Fatty Liver Disease	12.2%
27	Chronic active hepatitis	12.2%
28	Chemical and Drug Induced Liver Injury	11.7%
29	Hepatorenal Syndrome	11.2%
30	Esophageal and Gastric Varices	10.9%
31	Digestive System Neoplasms	10.2%
32	Porphyrias, Hepatic	9%
33	Hepatitis, Animal	8.8%
34	Hepatitis, Viral, Human	8.8%
35	Liver Abscess, Amebic	8.3%
36	Liver Cirrhosis, Experimental	8.2%
37	Gastrointestinal Neoplasms	7.7%
38	Pancreatic Fistula	7.6%
39	Bile Duct Diseases	7.6%
40	Cholelithiasis	7.6%
41	Chylous Ascites	7.6%
42	Esophageal Diseases	7.6%
43	Gastroenteritis	7.6%
44	Intestinal Diseases	7.6%
45	Pancreatic Insufficiency	7.6%
46	Pancreatitis	7.6%
47	Pneumoperitoneum	7.6%
48	Stomach Diseases	7.6%
49	Hepatocellular Adenoma	6.5%
50	Fascioliasis	6.3%
51	Echinococcosis, Hepatic	6.2%
52	Chemical and Drug Induced Liver Injury, Chronic	6.2%
53	Reye Syndrome	6.1%
54	Peritoneal Neoplasms	6.1%
55	Mesenteric vascular insufficiency	6%
56	Esophageal Atresia	5.9%
57	Intestinal Atresia	5.9%
58	Mesenteric Vascular Occlusion	5.9%
59	Intestinal Fistula	5.8%
60	Enterocutaneous Fistula	5.8%
61	Liver Neoplasms, Experimental	5.5%
62	Dysentery	5.5%
63	Enteritis	5.5%
64	Enterocolitis	5.5%
65	Esophagitis	5.5%
66	Gastritis	5.5%
67	Inflammatory Bowel Diseases	5.5%
68	Cholecystolithiasis	5.5%
69	Pancreatic Cyst	5.1%
70	Pancreatic Neoplasm	5.1%
71	Zollinger-Ellison syndrome	5.1%
72	Anus, Imperforate	5%
73	Gastrointestinal Hemorrhage	5%
74	Hemoperitoneum	5%
75	Mesenteric Panniculitis	5%
76	Panniculitis, Peritoneal	5%
77	Peritonitis	5%
78	Peritoneal Fibrosis	5%
79	Encapsulating Peritoneal Sclerosis	5%
80	Anorectal Malformations	5%
81	Biliary Fistula	5%
82	Gastric Fistula	5%
83	Autoimmune hepatitis	5%
84	Tuberculosis, Gastrointestinal	4.9%
85	Bile Duct Neoplasms	4.9%
86	gallbladder neoplasm	4.9%
87	Intestinal Neoplasms	4.9%
88	Stomach Neoplasms	4.9%
89	Variegate Porphyria	4.9%
90	Acute intermittent porphyria	4.9%
91	Porphyria Cutanea Tarda	4.9%
92	Hepatitis B, Chronic	4.8%
93	Hepatitis C, Chronic	4.8%
94	Choledochal Cyst	4.7%
95	Colitis	4.3%
96	Duodenogastric Reflux	4.3%
97	Peptic Ulcer	4.3%
98	Proctitis	4.3%
99	Choledocholithiasis	4.3%
100	Esophageal Neoplasms	4.1%
101	Gastrointestinal Stromal Tumors	4.1%
102	Cecal Diseases	4.1%
103	Cholangitis	4.1%
104	Cholecystitis	4.1%
105	Cholestasis	4.1%
106	Colonic Diseases	4.1%
107	Common Bile Duct Diseases	4.1%
108	Esophageal Stenosis	4.1%
109	Ileal Diseases	4.1%
110	Intestinal Obstruction	4.1%
111	Intestinal Perforation	4.1%
112	Jejunal Diseases	4.1%
113	Pneumatosis Cystoides Intestinalis	4.1%
114	Rectal Diseases	4.1%
115	Gastric Dilatation	4.1%
116	Pancreatitis, Chronic	4.1%
117	Gastric outlet obstruction	4.1%
118	Cronkhite-Canada Syndrome	4.1%
119	Intestinal Polyposis	4.1%
120	Zellweger Syndrome	4%
121	Hepatitis, Viral, Animal	3.9%
122	Hepatitis E	3.8%
123	Hepatitis B	3.7%
124	Hepatitis C	3.7%
125	Hepatitis A	3.7%
126	Hepatolenticular Degeneration	3.7%
127	Duodenitis	3.6%
128	Ileitis	3.6%
129	Erosive Duodenitis	3.6%
130	Rectal Fistula	3.5%
131	Anal Fistula	3.5%
132	Colorectal Neoplasms	3.4%
133	Appendicitis	3.3%
134	Cecal Neoplasms	3.2%
135	Crohn Disease	3.2%
136	Duodenal Neoplasms	3.2%
137	Duodenal Obstruction	3.2%
138	Enterocolitis, Neutropenic	3.2%
139	Necrotizing Enterocolitis	3.2%
140	Proctocolitis	3.2%
141	Cystic Fibrosis	3.1%
142	Congenital Hyperinsulinism	3%
143	Esophageal Perforation	2.9%
144	Intestinal Diseases, Parasitic	2.9%
145	Barrett Esophagus	2.8%
146	Deglutition Disorders	2.8%
147	Achlorhydria	2.7%
148	Pancreatic Pseudocyst	2.7%
149	Gastric Antral Vascular Ectasia	2.7%
150	Peptic Ulcer Hemorrhage	2.7%
151	Gastroparesis	2.7%
152	Pancreatitis, Alcoholic	2.7%
153	Duodenal Ulcer	2.7%
154	Peptic Ulcer Perforation	2.7%
155	Gastric ulcer	2.7%
156	Enterocolitis, Pseudomembranous	2.4%
157	pseudomembranous colitis	2.4%
158	Dysentery, Bacillary	2.4%
159	Cholestasis, Extrahepatic	2.4%
160	Biliary Dyskinesia	2.4%
161	Cholangitis, Sclerosing	2.4%
162	Colonic Diseases, Functional	2.4%
163	Esophageal motility disorders	2.4%
164	Fecal Incontinence	2.4%
165	Fecal Impaction	2.4%
166	Intussusception	2.4%
167	Mallory-Weiss Syndrome	2.4%
168	Megacolon	2.4%
169	Pyloric Stenosis	2.4%
170	Acalculous Cholecystitis	2.4%
171	Ileus	2.4%
172	Meconium ileus	2.4%
173	Pouchitis	2.4%
174	Appendiceal Neoplasms	2.1%
175	Colonic Neoplasms	2.1%
176	Rectal Neoplasms	2.1%
177	Melena	2.1%
178	Colitis, Ischemic	2%
179	Carcinoma, Pancreatic Ductal	2%
180	Hematemesis	2%
181	Colonic Pseudo-Obstruction	1.8%
182	Anus Neoplasms	1.8%
183	Sigmoid Neoplasms	1.8%
184	Adenomatous Polyposis Coli	1.8%
185	Hemorrhoids	1.7%
186	Afferent Loop Syndrome	1.6%
187	Celiac Disease	1.6%
188	Short Bowel Syndrome	1.6%
189	Sprue, Tropical	1.6%
190	Steatorrhea	1.6%
191	Rectocele	1.6%
192	Sprue	1.6%
193	Nesidioblastosis	1.6%
194	Diverticulitis	1.6%
195	Dumping Syndrome	1.6%
196	Rectal Prolapse	1.6%
197	Esophageal Achalasia	1.6%
198	Anal Fissure	1.6%
199	Intestinal Pseudo-Obstruction	1.6%
200	Irritable Bowel Syndrome	1.6%
201	Superior Mesenteric Artery Syndrome	1.6%
202	Emphysematous Cholecystitis	1.6%
203	Neurogenic Bowel	1.6%
204	Sphincter of Oddi Dysfunction	1.6%
205	Anal Ulcer	1.6%
206	Rift Valley Fever	1.4%
207	insulinoma	1.4%
208	Gastrinoma	1.4%
209	Glucagonoma	1.4%
210	Giardiasis	1.3%
211	Diverticulum	1.2%
212	Diverticulosis	1.2%
213	Vipoma	1.2%
214	Pruritus Ani	1.1%
215	Peutz-Jeghers Syndrome	1%
216	Lactose Intolerance	1%
217	Laryngopharyngeal Reflux	0.8%
218	Cryptosporidiosis	0.7%
219	CREST Syndrome	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120240