MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hepatopulmonary Syndrome

(UMLS:C0600452)

Definition:: A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
UMLS ID:: C0600452
MeSH ID:: D020065

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.455

Classification 2:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.385

Synonym(s)

Hepatopulmonary Syndrome

Hepatopulmonary syndrome

hepato pulmonary syndrome

hepatopulmonary syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methadone	FAERS: 2		US FAERS
2	pirfenidone	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Azathioprine	FAERS: 1		US FAERS
4	Cysteamine	FAERS: 1		US FAERS
5	Everolimus	FAERS: 1		US FAERS
6	Prednisolone	FAERS: 1		US FAERS
7	Ruxolitinib phosphate	FAERS: 1		US FAERS
8	Sildenafil Citrate	FAERS: 1		US FAERS
9	ambrisentan	FAERS: 1		US FAERS
10	treprostinil	FAERS: 1		US FAERS
11	Methadone		20583080	CTD
12	Ribavirin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Atelectasis	28.6%
2	Fatty Liver	28.6%
3	Hepatitis	28.6%
4	Portal Hypertension	28.6%
5	Pulmonary Hypertension	28.6%
6	Liver Cirrhosis	28.6%
7	Pneumonia	28.6%
8	Lobar Pneumonia	28.6%
9	Pulmonary Alveolar Proteinosis	28.6%
10	Pulmonary Edema	28.6%
11	Pulmonary Fibrosis	28.6%
12	Respiratory Distress Syndrome, Adult	28.6%
13	Hamman-Rich syndrome	28.6%
14	Lung Diseases, Interstitial	28.6%
15	Focal Nodular Hyperplasia	28.6%
16	Lung Diseases, Obstructive	28.6%
17	Hepatic Insufficiency	28.6%
18	Steatohepatitis	28.6%
19	Pneumonitis	28.6%
20	Idiopathic Pulmonary Fibrosis	28.2%
21	Biliary cirrhosis	27.5%
22	Pneumoconiosis	25.7%
23	Fatty Liver, Alcoholic	24.4%
24	Hepatitis, Alcoholic	24.4%
25	Liver Cirrhosis, Alcoholic	24.4%
26	Bronchitis	23.9%
27	Bronchitis, Chronic	23.6%
28	Lung Diseases, Fungal	22.9%
29	Liver neoplasms	22.5%
30	Respiratory Distress Syndrome, Newborn	22.5%
31	Lung Abscess	22.4%
32	Lung Neoplasms	22.4%
33	Tuberculosis, Pulmonary	22.3%
34	Bronchopneumonia	22.2%
35	Liver Diseases, Parasitic	22.2%
36	Hepatic Veno-Occlusive Disease	21.4%
37	Peliosis Hepatis	21.4%
38	Lung Injury	21.4%
39	Hepatomegaly	21.1%
40	Hepatitis, Chronic	20.9%
41	Chronic Obstructive Airway Disease	20.9%
42	Middle Lobe Syndrome	20.9%
43	Liver Failure	20.9%
44	Acute Lung Injury	20.9%
45	Non-alcoholic Fatty Liver Disease	20.9%
46	Chronic active hepatitis	20.9%
47	Pulmonary Embolism	20.9%
48	Hepatic Vein Thrombosis	20.8%
49	Liver Abscess	20.8%
50	Pulmonary Eosinophilia	20.8%
51	Budd-Chiari Syndrome	20.8%
52	Eosinophilic Pneumonia	20.8%
53	Esophageal and Gastric Varices	20.7%
54	Aspiration Pneumonia	20.7%
55	Radiation Pneumonitis	20.6%
56	Radiation Fibrosis	20.6%
57	Asbestosis	20.5%
58	Berylliosis	20.5%
59	Silicosis	20.5%
60	Pleuropneumonia	20.5%
61	Asthma	19.7%
62	Cystic Fibrosis	19%
63	Bronchiolitis	18.4%
64	Liver Abscess, Amebic	17.5%
65	Pulmonary Emphysema	17.2%
66	Liver Failure, Acute	17.2%
67	End Stage Liver Disease	17.2%
68	Pneumonia, Viral	17.1%
69	Chemical and Drug Induced Liver Injury	17.1%
70	Pneumonia, Lipid	16.9%
71	Pneumonia, Bacterial	16.7%
72	Hemoptysis	16.7%
73	Hepatorenal Syndrome	16.6%
74	Hepatitis, Animal	16.4%
75	Hepatitis, Viral, Human	16.4%
76	Hyaline Membrane Disease	16.3%
77	Multiple Pulmonary Nodules	16.3%
78	Hepatitis B, Chronic	15.9%
79	Hepatitis C, Chronic	15.9%
80	Persistent Fetal Circulation Syndrome	15.8%
81	Bronchiolitis Obliterans	15.6%
82	Histiocytosis, Langerhans-Cell	15.5%
83	Liver Cirrhosis, Experimental	15.5%
84	Pulmonary Aspergillosis	15.5%
85	Bronchopulmonary Aspergillosis	15.5%
86	Massive Hepatic Necrosis	15.4%
87	Sarcoidosis, Pulmonary	15.4%
88	Pulmonary Infarction	15.3%
89	Biliary Tract Diseases	15%
90	Bronchial Diseases	15%
91	Gastrointestinal Diseases	15%
92	Pancreatic Diseases	15%
93	Pleural Diseases	15%
94	Respiration Disorders	15%
95	Thoracic Diseases	15%
96	Tracheal Diseases	15%
97	Pleurisy	14.3%
98	Tracheitis	14.3%
99	Tracheobronchomegaly	14.1%
100	Aspergillosis, Allergic Bronchopulmonary	14%
101	Scimitar Syndrome	13.9%
102	Porphyrias, Hepatic	13.8%
103	Acute Chest Syndrome	13.5%
104	Hepatocellular Adenoma	13.5%
105	Autoimmune hepatitis	13%
106	Meconium Aspiration Syndrome	13%
107	Bronchopulmonary Dysplasia	12.8%
108	Fascioliasis	12.5%
109	Zollinger-Ellison syndrome	12.5%
110	Echinococcosis, Hepatic	12.4%
111	Chemical and Drug Induced Liver Injury, Chronic	12.3%
112	Reye Syndrome	12.2%
113	Granulomatosis with polyangiitis	12.2%
114	Farmer's Lung	11.9%
115	Liver Neoplasms, Experimental	11.7%
116	Laryngeal Diseases	11.5%
117	Nose Diseases	11.5%
118	Laryngitis	11.4%
119	Rhinitis	11.4%
120	Vocal Cord Dysfunction	11.4%
121	Gastrointestinal Neoplasms	11.3%
122	Bronchial Fistula	11.2%
123	Pancreatic Fistula	11.2%
124	Pleural Neoplasms	11.2%
125	Digestive System Neoplasms	11.1%
126	Respiratory Tract Infections	11.1%
127	Proctocolitis	11.1%
128	Granuloma, Laryngeal	10.9%
129	Granuloma, Respiratory Tract	10.9%
130	Respiratory Hypersensitivity	10.9%
131	Respiratory Tract Fistula	10.9%
132	Hepatitis, Viral, Animal	10.8%
133	Laryngopharyngeal Reflux	10.6%
134	Hepatitis E	10.5%
135	Dysentery	10.3%
136	Enteritis	10.3%
137	Enterocolitis	10.3%
138	Esophagitis	10.3%
139	Gastritis	10.3%
140	Hepatitis B	10.3%
141	Hepatitis C	10.3%
142	Inflammatory Bowel Diseases	10.3%
143	Cholecystolithiasis	10.3%
144	Transfusion-Related Acute Lung Injury	10.3%
145	Colorectal Neoplasms	10.3%
146	Hepatitis A	10.3%
147	Bile Duct Neoplasms	10.2%
148	gallbladder neoplasm	10.2%
149	Intestinal Neoplasms	10.2%
150	Stomach Neoplasms	10.2%
151	Anti-Glomerular Basement Membrane Disease	10.2%
152	Pleural Effusion, Malignant	10.1%
153	Hepatic Encephalopathy	10.1%
154	Invasive Pulmonary Aspergillosis	10.1%
155	Blastomycosis	10.1%
156	Duodenitis	10.1%
157	Ileitis	10.1%
158	Erosive Duodenitis	10.1%
159	Variegate Porphyria	10.1%
160	Acute intermittent porphyria	10.1%
161	Porphyria Cutanea Tarda	10.1%
162	Mesenteric vascular insufficiency	9.9%
163	Esophageal Atresia	9.7%
164	Intestinal Atresia	9.7%
165	Mesenteric Vascular Occlusion	9.7%
166	Sinusitis	9.7%
167	Intestinal Fistula	9.7%
168	Enterocutaneous Fistula	9.7%
169	Bronchial Neoplasms	9.6%
170	Altitude Sickness	9.5%
171	Bile Duct Diseases	9.5%
172	Bronchospasm	9.5%
173	Bronchiectasis	9.5%
174	Cholelithiasis	9.5%
175	Chylous Ascites	9.5%
176	Chylothorax	9.5%
177	Esophageal Diseases	9.5%
178	Gastroenteritis	9.5%
179	Hydropneumothorax	9.5%
180	Hydrothorax	9.5%
181	Intestinal Diseases	9.5%
182	Pancreatic Insufficiency	9.5%
183	Pancreatitis	9.5%
184	Pneumoperitoneum	9.5%
185	Pneumothorax	9.5%
186	Respiratory Insufficiency	9.5%
187	Stomach Diseases	9.5%
188	Tracheal Stenosis	9.5%
189	Bronchial Hyperreactivity	9.5%
190	Respiratory Depression	9.5%
191	Respiratory Failure	9.5%
192	Cecal Neoplasms	9.5%
193	Duodenal Neoplasms	9.5%
194	Choanal Atresia	9.4%
195	Laryngocele	9.4%
196	Colitis	9.4%
197	Duodenogastric Reflux	9.4%
198	Peptic Ulcer	9.4%
199	Proctitis	9.4%
200	Choledocholithiasis	9.4%
201	Peritoneal Neoplasms	9.3%
202	Tracheal Neoplasms	9.2%
203	Pouchitis	9%
204	Rectal Fistula	8.9%
205	Anal Fistula	8.9%
206	Anus Neoplasms	8.7%
207	Sigmoid Neoplasms	8.7%
208	Esophageal Neoplasms	8.7%
209	Crohn Disease	8.5%
210	Duodenal Obstruction	8.5%
211	Enterocolitis, Neutropenic	8.5%
212	Necrotizing Enterocolitis	8.5%
213	Appendiceal Neoplasms	8.4%
214	Colonic Neoplasms	8.4%
215	Rectal Neoplasms	8.4%
216	Laryngospasm	8.2%
217	Gastrointestinal Stromal Tumors	8.2%
218	Choledochal Cyst	8.1%
219	Asthma, Exercise-Induced	8.1%
220	Status Asthmaticus	8.1%
221	Laryngeal neoplasm	8%
222	Duodenal Ulcer	8%
223	Peptic Ulcer Perforation	8%
224	Gastric ulcer	8%
225	Pancreatic Neoplasm	8%
226	Appendicitis	7.5%
227	Colonic Pseudo-Obstruction	7.3%
228	Primary Ciliary Dyskinesia	7.3%
229	Eosinophilic Granuloma	7.2%
230	Granuloma, Lethal Midline	7.1%
231	Laryngeal Edema	7.1%
232	Nose Deformities, Acquired	7.1%
233	Pancreatic Cyst	7.1%
234	Respiratory Aspiration	7.1%
235	Anus, Imperforate	7%
236	Apnea	7%
237	Cheyne-Stokes Respiration	7%
238	Common Cold	7%
239	Dyspnea	7%
240	Gastrointestinal Hemorrhage	7%
241	Hemoperitoneum	7%
242	Hemothorax	7%
243	Hyperventilation	7%
244	Influenza	7%
245	Mesenteric Panniculitis	7%
246	Mouth Breathing	7%
247	Panniculitis, Peritoneal	7%
248	Peritonitis	7%
249	Tachypnea	7%
250	Peritoneal Fibrosis	7%
251	Catarrh	7%
252	Encapsulating Peritoneal Sclerosis	7%
253	Anorectal Malformations	7%
254	Asthma, Occupational	7%
255	Airway Obstruction	7%
256	Cecal Diseases	7%
257	Choking	7%
258	Cholangitis	7%
259	Cholecystitis	7%
260	Cholestasis	7%
261	Colonic Diseases	7%
262	Common Bile Duct Diseases	7%
263	Epiglottitis	7%
264	Esophageal Stenosis	7%
265	Ileal Diseases	7%
266	Intestinal Obstruction	7%
267	Intestinal Perforation	7%
268	Jejunal Diseases	7%
269	Mediastinitis	7%
270	Pneumatosis Cystoides Intestinalis	7%
271	Rectal Diseases	7%
272	Gastric Dilatation	7%
273	Pancreatitis, Chronic	7%
274	Gastric outlet obstruction	7%
275	Cronkhite-Canada Syndrome	7%
276	Intestinal Polyposis	7%
277	Biliary Fistula	7%
278	Gastric Fistula	7%
279	Severe Acute Respiratory Syndrome	6.9%
280	Tuberculosis, Gastrointestinal	6.9%
281	Adenomatous Polyposis Coli	6.9%
282	Paranasal Sinus Neoplasms	6.7%
283	Enterocolitis, Pseudomembranous	6.7%
284	pseudomembranous colitis	6.7%
285	Dysentery, Bacillary	6.7%
286	Zellweger Syndrome	6.6%
287	Colitis, Ischemic	6.5%
288	Hepatolenticular Degeneration	6.1%
289	Nose Neoplasms	6.1%
290	Hay fever	6.1%
291	Rhinitis, Allergic, Perennial	6.1%
292	Rhinoscleroma	6.1%
293	Hoarseness	6%
294	Asthma, Aspirin-Induced	5.8%
295	Rift Valley Fever	5.8%
296	Cholestasis, Extrahepatic	5.7%
297	Biliary Dyskinesia	5.7%
298	Cholangitis, Sclerosing	5.7%
299	Colonic Diseases, Functional	5.7%
300	Esophageal motility disorders	5.7%
301	Fecal Incontinence	5.7%
302	Fecal Impaction	5.7%
303	Intussusception	5.7%
304	Mallory-Weiss Syndrome	5.7%
305	Megacolon	5.7%
306	Pyloric Stenosis	5.7%
307	Acalculous Cholecystitis	5.7%
308	Ileus	5.7%
309	Meconium ileus	5.7%
310	Pharyngitis	5.7%
311	Laryngostenosis	5.6%
312	Nasal Polyps	5.6%
313	Pertussis	5.5%
314	Maxillary Sinus Neoplasms	5.5%
315	Esophageal Perforation	5.5%
316	Intestinal Diseases, Parasitic	5.5%
317	Kartagener Syndrome	5.3%
318	Barrett Esophagus	5.3%
319	Deglutition Disorders	5.3%
320	Mediastinal Cyst	5.3%
321	Pericardial Cyst	5.3%
322	Thymic Cyst	5.3%
323	Achlorhydria	5.2%
324	Croup	5.2%
325	Mediastinal Emphysema	5.2%
326	Pancreatic Pseudocyst	5.2%
327	Rhinitis, Vasomotor	5.2%
328	Gastric Antral Vascular Ectasia	5.2%
329	Hypoventilation	5.2%
330	Esophageal Achalasia	5.1%
331	Anal Fissure	5.1%
332	Intestinal Pseudo-Obstruction	5.1%
333	Irritable Bowel Syndrome	5.1%
334	Superior Mesenteric Artery Syndrome	5.1%
335	Emphysematous Cholecystitis	5.1%
336	Neurogenic Bowel	5.1%
337	Sphincter of Oddi Dysfunction	5.1%
338	Anal Ulcer	5.1%
339	Acidosis, Respiratory	5.1%
340	Alkalosis, Respiratory	5.1%
341	Peptic Ulcer Hemorrhage	5.1%
342	Sleep Apnea Syndromes	5.1%
343	Gastroparesis	5.1%
344	Pancreatitis, Alcoholic	5.1%
345	Voice Disorders	4.7%
346	Voice Disturbance	4.7%
347	Epistaxis	4.7%
348	Congenital Hyperinsulinism	4.6%
349	Carcinoma, Pancreatic Ductal	4.4%
350	Hemorrhoids	4.3%
351	Afferent Loop Syndrome	4.3%
352	Celiac Disease	4.3%
353	Short Bowel Syndrome	4.3%
354	Sprue, Tropical	4.3%
355	Steatorrhea	4.3%
356	Rectocele	4.3%
357	Sprue	4.3%
358	Diverticulitis	4.2%
359	Dumping Syndrome	4.2%
360	Rectal Prolapse	4.2%
361	Sleep Apnea, Obstructive	4.2%
362	Sleep Apnea, Central	4.2%
363	Melena	4.1%
364	Tonsillitis	4.1%
365	insulinoma	4.1%
366	Gastrinoma	4.1%
367	Glucagonoma	4.1%
368	Dyspnea, Paroxysmal	4.1%
369	Respiratory Paralysis	4.1%
370	Hematemesis	4.1%
371	Laryngomalacia	4%
372	Vocal Cord Paralysis	3.9%
373	Pruritus Ani	3.8%
374	Vipoma	3.6%
375	Giardiasis	3.5%
376	Diverticulum	3.4%
377	Diverticulosis	3.4%
378	Aphonia	3.4%
379	Retropharyngeal Abscess	3.4%
380	Dysphonia	3.4%
381	Bronchomalacia	3.4%
382	Tracheomalacia	3.4%
383	Nesidioblastosis	3.4%
384	Nasopharyngitis	2.9%
385	Peutz-Jeghers Syndrome	2.8%
386	Lactose Intolerance	2.8%
387	Peritonsillar Abscess	2.8%
388	Cryptosporidiosis	2.1%
389	CREST Syndrome	1.9%

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